A new way of screening for ovarian cancer is showing "potential", according to researchers in the US.

Tumours in the ovaries are hard to detect in the earliest stages meaning it can be too late to treat them effectively by the time they are found.
A trial of 4,051 women, reported in the journal Cancer, showed the method could identify those needing treatment.
But a huge study taking place in the UK will give a final verdict on the test when it is completed in 2015.
There is a survival rate of up to 90% when ovarian cancer is caught early, compared with less than 30% if it is discovered in the later stages.
Unlike other cancers, the symptoms, such as pelvic and abdominal pain or persistent bloating, are often put down to other common ailments and the tumour can be missed.
There is no mass screening programme to detect the cancer either.
Scientists already know that levels of a protein in the blood, called CA125, are often higher with ovarian cancer.
However, it is too unreliable on its own. It misses some patients and tells others they have the cancer when they are actually healthy.
Researchers are now testing the idea of using the blood test to sort patients in risk groups based on levels of CA125. Instead of going straight for surgery, low-risk patients are tested again in a year, medium-risk ones after three months and high-risk patients have an ultrasound scan to hunt for tumours.
The US study, at the University of Texas, followed post-menopausal women for 11 years on average.
Ten women had surgery based on their ultrasound scan and all the cancers detected were at an early stage.
Researcher Dr Karen Lu told the BBC: "Clinical practice definitely should not change from our study, but it gives us an insight - we didn't get a lot of false positives."
She said the UK study of 50,000 people would give definitive results: "There are two big questions - do we see cancers at an earlier stage and do we decrease the number of deaths."
Dr Sarah Blagden, from the Ovarian Cancer Action research centre, said: "Relative to the trial under way in the in the UK , this is a small study, but it does show that effective ovarian screening is possible.
"In 2015 the results of the UKCTOCs study will become available and the results are eagerly anticipated, more so now that this American study has produced such encouraging results."
Annwen Jones, the chief executive at Target Ovarian Cancer, said: "The results of this study are without doubt very positive, and we should take hope from that.
"Early detection of ovarian cancer will be the key to transforming survival rates.  However, this study is very small, and there is no guarantee that the results will be replicated on a larger scale."


More than half of us bought a "free from" product during the last three months, according to Kantar Worldpanel.

Younger people are leading a trend towards buying products without dairy and gluten in particular.
UK supermarkets are increasingly stocking aisles with wide ranges of the products, from biscuits to bolognaise.
"Consumers are associating 'free from' with a natural form of health in general," said Fraser McKevitt of the consumer research firm.
He said that while only about 5% of the population needed to avoid certain food groups for medical reasons, 54% of households joined the trend in the first three months of this year by buying at least one product from the category.
In recent years, a fashion for "clean eating", paleo, vegan and other diets popularised online has boosted the market for specially manufactured products and encouraged supermarkets as well as specialist stores to stock more of them.
Compared with last year's survey, 3.3 million more people had purchased a "free from" product, said Mr McKevitt.
Households containing people aged under 45 were 20% more likely to buy from these ranges. Sales of "free from" products grew 36% compared with a year earlier, he said.
Kantar monitors shoppers' habits using a sample of 30,000 households.
"The majority of products are bought by people who do not identify as having an intolerance," said Mr McKevitt, head of retail and consumer insight at Kantar.
He said shoppers used the label as a short-cut to identify products they believed would be healthier.
Ursula Philpott, a dietician at Leeds Beckett University, said that for the section of the population that did suffer from allergies and intolerances, the increased availability of these products was very helpful, but most of people did not need to avoid any specific food groups.
"A lot of people will be buying these because they've been sold the idea that gluten or dairy are in some way bad for you and that that's science-based, which for most people just isn't the case," she said.
"If we look at studies over the long term, we know the types of diets that lead to us having longer lives or having less disease states are things like Mediterranean diets, which don't include cutting out lots of things."
Kantar Worldpanel's survey also indicated that sales of "free from" products were higher amongst a more affluent demographic, reflected in higher sales of the products at Waitrose and Sainsbury's, compared with those grocers' market share.
But discounters Aldi and Lidl were also selling significant amounts of these products, said Mr McKevitt.
"Meanwhile, inflation shows no signs of abating. The price of everyday goods is up by 2.3% compared to this time last year, and rising prices cost the average household an additional Â£21.31 during the past 12 weeks," he added.
"We expect inflation to continue to accelerate, and as a result, we're likely to see consumers looking for cheaper alternatives."
The latest figures from Kantar Worldpanel indicate that prices for butter, fish, tea and skincare have risen in the 12 weeks to 26 March, while categories including crisps, bacon, chocolate and fresh poultry have seen prices fall.
Discount retailers Aldi and Lidl have continued to increase sales by about 15%, whereas Tesco, Sainsbury's and Asda saw their sales decline slightly. Iceland has also seen a boost to sales.
Aldi and Lidl now account for 11.7% of the UK grocery market.


Japan and the US have unveiled new guidelines on their defence co-operation as Japanese leader Shinzo Abe visits the US for talks.

The guidelines allow Japan to take on a more assertive military role and clarify US support for Japan.
Secretary of State John Kerry said US commitment to Japan's defence was "ironclad", including disputed islands.
Japan's pacifist constitution currently allows only for self-defence, but Mr Abe has called for a re-interpretation.
Any change is likely to seriously alarm Japan's East Asian neighbours.
Mr Abe was set to visit the site of the 2013 Boston marathon bombing on Monday before travelling to Washington ahead of talks on Tuesday with President Barack Obama.
The changes were announced in New York by Mr Kerry and Japanese Foreign Minister Fumio Kishida.
"The guidelines that we have worked on that have been announced today will enhance Japan's security, deter threats and contribute to regional peace and stability", Mr Kerry said.
"The United States and Japan stand together in calling for disputes in the region to be resolved peacefully."
Mr Kerry also renewed the US security pledge over the islets known as the Senkakus in Japan and the Diaoyus in China.
China has disputed Japan's territorial claim to the islands, which are close to important shipping lanes, offer rich fishing grounds and lie near potential oil and gas reserves
The new guidelines are expected to reflect Japan's shift in its defence aspirations which were outlined in a cabinet resolution last July. Any further military muscle for Japan would mean an overhaul of its constitution.
"The cabinet resolution and legislation being crafted now have gone right up to the limits of what is possible under the constitution as it is now," Reuters reported Hajime Funada, head of a ruling party panel on constitutional reform, as saying.
The US says that it would welcome an emboldened Japan.
"We very much welcome the fact that Japan is looking to play a more constructive role in promoting peace and stability in the broader Asia-Pacific region," US foreign policy aide Ben Rhodes told AFP news agency.
"We believe that that dovetails very nicely with the US rebalance," he said.
An opinion poll released on Monday by Japan's Sankei Shimbun newspaper showed 49.5% of Japanese voters opposed legal changes that would allow the Japanese military to fight abroad.
Hours ahead of the announcement, a crowd gathered outside the Japanese prime minister's office in Tokyo, chanting slogans against the revisions.


Forfar Sheriff Court will stop conducting jury trials at the end of this year, with cases being transferred to Dundee.

The Scottish Courts and Tribunals Service (SCTS) said the decision was part of changes to improve the "consistency and quality of service."
Trials heard before a sheriff only will continue to be held at Forfar.
Forfar is the only sheriff court in Angus, following the closure of Arbroath Sheriff Court in 2014.
Solemn cases - those held before a jury - will call at Forfar Sheriff Court until January.
A Dundee Sheriff Court source told BBC Scotland: "Solemn business at Dundee is very efficient at the moment.
"I don't see any issues.  If there were any, it would be around accommodation, like the number of interview rooms and cells available, and witnesses having to travel."
A SCTC spokesman said: "A consultation meeting was held in Forfar on 12 July at which the new programme and the procedures and arrangements for solemn work in Dundee were discussed with local court users who attended.
"We can confirm that, after consideration, Sheriff Principal Lewis has decided that solemn business from Forfar Sheriff Court will move to Dundee Sheriff Court.
"First diets will move to Dundee from August of this year and will be managed in Dundee.
"The cases, if proceeding to trial, will go back to Forfar and call in the Forfar sheriff and jury sittings until January when all solemn business will move to Dundee."


Fire crews were called out after a taxi burst into flames outside the main terminal of Glasgow airport.

The emergency services were alerted after an electrical fire broke out in the car at about 13:50.
The Scottish Fire and Rescue Service dispatched a crew to the scene, and a firefighter wearing breathing apparatus extinguished the flames with a hose jet.
Airport operations were not disrupted by the blaze and no-one was injured.
A police spokesman said the vehicle would be recovered in due course.


The Prince of Wales will inspect troops from the 1st Queen's Dragoon Guards  - the Welsh Cavalry - in Swansea next week, it has been announced.

The soldiers will be exercising their right to march through the city, after returning from a final Afghan tour.
They were the last group of British forces to leave Helmand Province earlier this year, when the UK's operations came to an end.
Prince Charles is Colonel in Chief of the regiment.


East Fife were confirmed as Scottish League Two champions after a stalemate at second-placed Clyde.

A draw was enough for Gary Naysmith's side with rivals Annan and Queen's Park dropping points.
Clyde survived a goalmouth scramble before a shot from the hosts' Jordan Kirkpatrick went narrowly wide.
Steven Campbell went close for East Fife with a strike that just cleared the crossbar but the visitors did not need to score to seal promotion.
Match ends, Clyde 0, East Fife 0.
Second Half ends, Clyde 0, East Fife 0.
Mark McLaughlin (Clyde) wins a free kick in the attacking half.
Foul by Jamie Insall (East Fife).
Attempt missed. Chris Smith (Clyde) left footed shot from outside the box is too high.
Corner,  East Fife. Conceded by Mark McLaughlin.
David Marsh (Clyde) is shown the yellow card for a bad foul.
Foul by David Marsh (Clyde).
Kevin Smith (East Fife) wins a free kick in the attacking half.
Substitution, Clyde. John Gemmell replaces Ross Millen.
Kevin Smith (East Fife) is shown the yellow card for a bad foul.
Foul by Kevin Smith (East Fife).
David Marsh (Clyde) wins a free kick on the left wing.
Hand ball by Kevin Smith (East Fife).
Jason Kerr (East Fife) wins a free kick on the left wing.
Foul by David Gormley (Clyde).
Foul by Steven Campbell (East Fife).
Sean Higgins (Clyde) wins a free kick in the defensive half.
Substitution, East Fife. Jamie Insall replaces Ross Brown.
Substitution, Clyde. Paul Slane replaces Jordan Kirkpatrick.
Foul by David Gormley (Clyde).
(East Fife) wins a free kick in the attacking half.
Corner,  Clyde. Conceded by Jonathan Page.
Jordan Austin (East Fife) wins a free kick on the left wing.
Foul by David Gormley (Clyde).
Attempt missed. Patrick Slattery (East Fife) right footed shot from the centre of the box is close, but misses to the right.
Sean Higgins (Clyde) is shown the yellow card.
Kyle Wilkie (East Fife) wins a free kick in the defensive half.
Foul by David Marsh (Clyde).
Corner,  Clyde. Conceded by Gary Naysmith.
Hand ball by Jonathan Page (East Fife).
Attempt missed. Sean Higgins (Clyde) right footed shot from the centre of the box is close, but misses to the right.
Mark McLaughlin (Clyde) is shown the yellow card for a bad foul.
Gary Naysmith (East Fife) wins a free kick on the right wing.
Foul by Mark McLaughlin (Clyde).
Corner,  Clyde. Conceded by Jonathan Page.
Foul by Jonathan Page (East Fife).
Jamie Watson (Clyde) wins a free kick in the defensive half.
Kevin Smith (East Fife) wins a free kick on the right wing.
Foul by Jordan Kirkpatrick (Clyde).


Nigeria were eliminated from the African Nations Championship (CHAN) in Rwanda following a 1-0 loss to Guinea, who progress to the quarter-finals.

Tunisia also advanced to the last eight as winners of Group C thanks to a 5-0 win over Niger.
Sunday Oliseh's Nigeria side needed just a draw to qualify but lost to a Ibrahima Sory Sankhon goal.
Esperance's Saad Bguir (pictured) scored a brace before half-time to set Tunisia on their way to victory.
Guinea's winner came on the stroke of half-time as Sankhon turned the ball in from the edge of Nigeria's the six-yard box.
After Guinea dominated the first half Oliseh tried to change things soon after the break when he brought on Elvis Chikatara.
But the man who scored four of Nigeria's goals at the tournament was unable to find the equaliser that would have taken his side through.
Bguir's first for Tunisia came after just four minutes with a low scuffed shot from just outside the Niger area.
The with five minutes until half-time defensive mix-up allowed Tunisia to get in behind the Niger defence and Bguir fired the ball into the roof of the net from a neat pull back.
Ahmed Akaichi added a third, and his fourth of the tournament, with 13 minutes left to play.
The rout was completed minutes with goals from Ali Maaloul and Hichem Essifi for coach Hatem Missaoui's side.
He is in charge of the team in Rwanda as Henry Kaszperczak is resting after undergoing surgery.


The mother of a Scottish zookeeper mauled to death by a tiger at a zoo in Cumbria four years ago says she is still waiting for an apology.

Fiona McClay's daughter Sarah, 24, suffered "unsurvivable" injuries when a Sumatran tiger walked through a door that was meant to be locked, and pounced on her in May 2013.
Last year the zoo, now known as South Lakes Safari Zoo, admitted breaching health and safety laws.
It emerged a "self-locking door" was poorly maintained and malfunctioned.
The zoo, in Dalton-in-Furness, was fined Â£297,500 at Preston Crown Court for failing to ensure the safety of staff. This month, councillors refused a licence application for the zoo after hearing that almost 500 animals had died there within four years.
All this is little consolation to Fiona McClay who says she was offered no sympathy or support over her daughter's unnecessary death.
"I have heard nothing from the zoo. I've still heard nothing," she told BBC Radio Scotland.
"The only contact I've had with the owner of the zoo was at one of the preliminary hearings to the prosecution case brought by the council, and he held a door open for me, just as anyone would do."
There were no flowers from the zoo at Sarah's funeral. Her mother claims there was even some question over whether her work colleagues would be able to attend.
Ms McClay remains upset about comments made in the immediate aftermath of the tragedy which seemed to imply Sarah was to blame.
"I remember the zoo owner stating to the press that Sarah was in the wrong place. And he was also saying that she had done something wrong.
"That was hard to understand. Whenever I was given permission to read the police statement that the owner had given, he was saying things about a person I did not know."
Fiona recalls how her daughter's fascination with wildlife began at an early age. Family pets included stick insects, hamsters, ferrets, rats and geckos.
"It was wild things - it wasn't just animals. It was wildlife and flowers and everything about that natural world that affected her."
She studied animal conservation and biology at university. Her first jobs were part-time, as a veterinary nurse and promoting the conservation of red squirrels.
As a child she had visited South Lakes Wild Animal Park, as it was formerly known.
When a job there came up, she embraced the chance to work full-time with animals.
"She was always first there and was always last to leave. It wasn't just a nine to five job," said her mother.
Initially working with birds, Sarah, originally from Glasgow, was soon given a role caring for the big cats.
"She was so excited about it because it was greater responsibility."
Her mother believes she was happy in her work  - although she had misgivings about the way staff were treated and was investigating the possibility of setting up a trade union.
The day Sarah was fatally injured she remembers the "terrible" four-hour drive from Scotland to the hospital in Lancashire.
"I was telling myself the best, that perhaps she had been maimed in some way and had lost a limb, something like that. I don't think it ever went through my head that she had passed away until I was actually told."
Fiona draws some meagre solace from medical evidence that her daughter's death would have been quick.
The family asked for the tiger, Padang, not to be put down at the time but he was euthanised because of his age last year.
The zoo's owner, David Gill, no longer has any role in the running of the zoo. It remains open, run by Cumbria Zoo Company Ltd, pending an appeal against the decision not to grant an operating licence.
Fiona McClay believes the zoo should be closed for now  - although not, perhaps, indefinitely.
In the meantime, she lives with the memory of a child who had grown up to become a friend, sharing secrets - but whose potential was cut short by one of the creatures she loved.
"When people say when you lose child, they lose a part of their life, it's absolutely true.
"It's not to say that every day I'm in tears and every moment I'm thinking about Sarah but there are times every day when I think 'I should have told Sarah that'."
The BBC contacted David Gill's solicitor about Fiona McClay's comments. He said his client was unwilling to offer any comment on any matter relating to the zoo while the licence was under the legal and regulatory process.
The current operator of the zoo, Cumbria Zoo Company Ltd, issued the following statement: "We have work to do, we know we do.  A modern zoo should continually strive to be better in all it does.
"We are pushing hard to meet our goals, without compromise to achieve high standards for the animals in our care and for our staff and local community and we drive forward to earn Safari Zoo its place in the modern zoo community. Your support is all the more vital now."


Walk On By singer Dionne Warwick has filed for bankruptcy in the US after amassing debts of almost $10 million (£6.6m) in taxes since 1991.

The singer's liabilities include nearly $7m owed to the IRS (Internal Revenue Service) from 1991 to 1999 and more than $3m in business taxes owed to the state of California, where she lives.
Warwick, 72, has sold more than 100 million records since the 1960s.
Her publicist said she had been the victim of poor financial management.
He added that Warwick had paid back the actual amount of the taxes but not penalties and interest that had accumulated over the years.
In documents filed in her home state of New Jersey this month, the singer of such classics as I Say A Little Prayer listed about $21,000 (£13,800) in monthly income and a similar amount in monthly expenses.
Her publicist said she had "repeatedly attempted to offer re-payment plans and proposals to the IRS and the California Franchise Tax Board for taxes owed".
Warwick, cousin of the late Whitney Houston, won her first of five Grammy awards in 1968 with Do You Know The Way To San Jose?
Her second came two years later, for the album I'll Never Fall In Love Again.
She has enjoyed more charts hits than almost any other female singer.
Last March, Warwick celebrated 50 years in show business with a special event at the Grammy Museum in Los Angeles.
To mark the anniversary she released Now, an album featuring new versions of some of her most famous songs.


British Airways has apologised to passengers who faced long delays at check-in at Heathrow and Gatwick airports on Sunday.

The airline is upgrading its check-in system and problems led to lengthy queues on one of the busiest days of the year for the airports.
Among those affected was TV presenter Phillip Schofield, who ended up missing his flight at Heathrow.
BA says the problems have been resolved and flights are operating normally.
Other passengers also tweeted about missing flights or facing delays of up to four hours, which were described by some as "chaos".
BA apologised for the delays and said it had extra staff in place to help customers. Some were rebooked on alternative flights, it said.
The airline said it had been phasing in the roll-out of a new world-wide check-in system since October 2015, which more than 10 million customers have already used.
A spokesman added: "Our IT teams worked very hard to quickly fix a short-lived problem with our check-in system.
"We are sorry for the delays some customers had as they checked in for their flights."


A former Catholic boarding school pupil who accused a priest of "horrific" sexual abuse made up the claims to get compensation, a court has heard.

Father Michael Higginbottom, 74, is accused of subjecting a teenage boy to repeated sexual abuse in the 1970s.
The assaults are said to have taken place when he was a teacher at St Joseph's College in Lancashire.
The priest denies four counts of a serious sexual offence and indecent assault.
Liverpool Crown Court heard previous allegations had been made against Mr Higginbottom by another pupil in 2007 and the Catholic Church had settled out of court for Â£35,000.
But Adam Birkby, defending, said although the priest had been charged, no evidence against him was offered in court and not guilty verdicts were entered.
In his closing speech, Mr Birkby said the complainant in the current case had read about the settlement and lied about being abused.
He said: "I say that he has fabricated these allegations of sexual abuse against Michael Higginbottom with the clear aim of achieving thousands of pounds of compensation."
The alleged victim, who said the abuse happened when he was aged 13 and 14, went to the police in 2014.
David Temkin, prosecuting, told the jury the complainant had said the case was not about compensation, but about justice.
In his evidence, Mr Higginbottom, of West Farm Road, Newcastle, told the court he had no memory of the alleged victim and had not sexually abused him.
The court has heard the school, which was based in the Upholland area and has now closed, was attended by boys aged 11 to 18, many of whom were considering a career in the priesthood.
The alleged victim, now in his 50s, told police it was the venue for "mental, physical and sexual abuse".


Mining companies helped push London's leading shares higher, with the FTSE 100 closing up 10.21 points, or 0.2%, at 6,278.97.

Antofagasta was up 5.8%, Glencore climbed 5%, while Anglo American was 4.3% higher.
Shares in airlines fell as confidence among investors was affected by news of more security alerts and the police operation in Paris.
British Airways owner IAG fell 3.2%, while easyJet was down 0.9%.
Outside the FTSE 100, UK Mail shares fell 12.1% after poor half-year results.
The delivery company reported pre-tax profits of Â£2.2m, down from Â£12m a year ago, and warned that its expectations for the next financial year "have softened slightly".
Nerves returned to global stock markets as worries about international security increased.
On Tuesday, a football match between Germany and the Netherlands was cancelled, while two Air France planes heading to Paris from the US were diverted because of security threats.
Investors were also eyeing developments in Paris, where armed police raided a flat in the suburb of Saint Denis in an operation linked to Friday's attacks.
Stock markets were lower across Europe, with France's Cac 40 index down 0.6% at 4,906.72, while Germany's Dax index dropped 0.1% to 10,959.95.
On the currency markets, the pound spiked briefly after Bank of England deputy governor Ben Broadbent said markets should look at how the UK's economy was performing, rather than "focus obsessively" on the Bank's forecasts.
The recent Inflation Report from the Bank was interpreted as pushing the prospect of a rate rise back to late 2016 or even early 2017.
However, Mr Broadbent's comments were seen as suggesting a rise could come earlier, and the pound jumped half a cent against the dollar in response.
However, the gains did not last, with the pound unchanged against the dollar at $1.5208, and up very slightly against the euro at â‚¬1.4304, in late afternoon.


Wagons used to empty recycling wheelie bins in Birmingham are too wide to fit down some streets, the council said.

There was not enough thought about vehicles reflecting routes and a "one size fits all" approach was wrong, the cabinet member for refuse told BBC WM.
But the council said most people who had received wheelie bins for recycled waste said streets were now cleaner and the service was working.
A two-week review of all vehicles and routes started this week.
Updates on this story and more from Birmingham
Lisa Trickett said collections were fine in "99.9%" of streets in the city.
But she said: "There was not enough thought given when the routes were planned.
"Local intelligence was not used to shape the service.
"My point to managers was when they were designing the specification, surely they actually took the time to think of the roads and the routes... and what vehicles would need to be reflected? That was not the case."
She said there were a number of roads in the city where "normal-sized wagons" had been deployed where it was now apparent other vehicles were needed.
"You cannot overhaul a service like the fleet and waste service that we inherited without some problems.
"I sincerely apologise for all of the problems that have been caused over the Christmas period."
Edgbaston resident Pranav Gupta said his recycled waste had not been properly collected since November, when the wheelie bin system had been introduced on his street.
"They never actually bring a recycling waste wagon to collect the rubbish, even if it's reported as a missed collection."


If you have ever wanted to become a post master or mistress, this could be your chance.

Caerwent Post Office in Monmouthshire is facing closure as illness is forcing its current tenants to leave.
Sarah and Simon Woodfield, who took on the post office just over four years ago, said they have made it the "hub" of the rural community.
But they are struggling to find someone to take over the business - and its accompanying house.
They have advertised the property but despite lots of interest, nobody has made an offer, Mrs Woodfield said.
She is now concerned locals - many of them elderly and unable to drive - will end up feeling isolated as all other shops in the rural village have closed down.
Their next nearest post office would be in Rogiet or Caldicot.
"The clock is ticking. We just want someone with the enthusiasm and vigour to take the post office forward," said Mrs Woodfield.
The post office has been the centre of village life since 1932.
After taking it on four years ago, the Woodfields, who are local to Caerwent - revamped it and decided to stock "a little bit of everything" that people would need, from groceries and gifts to coffee and fresh cakes.
But they are being forced to stand down after Mrs Woodfield was diagnosed with fibromylagia - a long-term condition that causes pain all over the body and extreme tiredness - and struggled to run the branch full time.
The Reverend John Waters, parish priest of St Stephen and St Tathan, said the post office was valued in the community.
"For example, people know I'm here on a regular basis so they know that if they can't get hold of me any other way they can leave  a message with Sarah and she will ensure I get it," he said.
"So it's all working together to promote communication and caring about each other and each other's needs."
At that point any potential new operator would submit a business case and undertake the normal Post Office recruitment processes.
The Post Office spokesman said it would work to try to find someone else to run the branch if the Woodfields were not able to find anyone.
He said the number of post office closures in Wales had remained stable over the last three years, with 931 currently open. In 2015 the figure stood at 930 and in 2016 it was at 919.
"We would like to reassure customers that the Post Office is committed to maintaining a Post Office service in Caerwent and will work hard to ensure this," he added.


Eight-time Olympic gold medallist Usain Bolt will not be able to play in Manchester United Legends' game against Barcelona at Old Trafford on 2 September due to injury.

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It had been planned for the 30-year-old sprinting great, a lifelong United fan, to play in the fixture, which will raise money for the Manchester United Foundation.
However, Bolt suffered a hamstring injury as he ran the final leg of the 4x100m relay at the World Athletics Championships in London on Saturday.
The Jamaican - the world record holder in both the 100m and 200m - has had further scans on the injury, which showed the damage to be worse than anticipated.
Bolt, who also won 11 world titles, has now retired from sprinting.
Former United players Edwin van der Sar, Paul Scholes, Denis Irwin, Dwight Yorke, Phil Neville, Ronny Johnsen, Louis Saha, Mikael Silvestre, Jesper Blomqvist, Quinton Fortune and Dion Dublin are all expected to take part in the charity game.
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Bolt tweeted an image of his muscle tear and said the injury will require three months of rehabilitation.
The Jamaican could only manage bronze in his penultimate race - the men's 100m at London 2017 - before pulling up injured just as he began to hit top speed in his final event, the 4x100m relay, last Saturday.
It meant the 19-time global champion, recently described by Lord Coe, the president of athletics' governing body the IAAF, as "a genius" akin to boxing legend Muhammad Ali, bowed out being helped off the track by his team-mates, barely able to stand upright.
"I don't usually release my medical report to the public but sadly I have sat and listened to people questioning if I was really injured," Bolt said on social media, before later deleting the posts.
"I have never been one to cheat my fans in any way and my entire desire at the championship was run one last time for my fans."


Former St Mirren full-back David van Zanten has joined Dumbarton on a one-year deal, with the option of staying for a further 12 months.

The 32-year-old was released by the Paisley club after making more than 330 appearances over two stints.
"He's played at the highest level in Scotland and is top flight quality," manager Ian Murray told the club website.
"A player of his calibre opting to join us is a very good sign."
A League Cup winner with the Buddies in 2013, Van Zanten, who also had spells at Hibs, Morton and Hamilton, made 18 appearances last season.
Van Zanten is the Championship club's second summer signing, following Scott Taggart's move from Morton.


Shares in HSBC fell nearly 3% following a surprise fourth quarter loss and predictions of a "bumpier" road ahead because of China's slowing economy.

In the final three months of last year, HSBC reported a pre-tax loss of $858m compared with a profit in the fourth quarter of 2014.
For the full-year, pre-tax profit was flat, up just 1% to $18.9bn (Â£13.1bn).
HBSC also confirmed that it is being investigated over its hiring practices in Asia.
Shares in Europe's largest bank fell 2.9% to 436p in mid-morning trading, hit by the unexpected loss in the fourth quarter because of write downs on the value of loans and declining income from lending.
Looking ahead, chairman Douglas Flint said: "China's slower economic growth will undoubtedly contribute to a bumpier financial environment."
Asia accounted for 83.5% of HSBC's global pre-tax profit last year.
However, Mr Flint said that he expects China "to be the largest contributor to global growth as its economy transitions to higher added value manufacturing and services and becomes more consumer driven".
The bank also said it had changed its outlook on interest rates and no longer expects the UK rate to rise in 2016, echoing Ross McEwan, chief executive of Royal Bank of Scotland, who does not forecast any move from the Bank of England until 2017.
The lender's group chief executive, Stuart Gulliver, noted the bank had seen a tough year in 2015, but that it was continuing to focus on delivering cost cutting measures announced in June last year.
"Targeted investment, prudent lending and our diversified, universal banking business model helped us achieve revenue growth in a difficult market environment, whilst also reducing risk-weighted assets," said Mr Gulliver.
Also, Mr Gulliver's pay fell by 6% to Â£7.3m because of higher costs, including the bank levy and write downs on bad loans, on which his pay is dependent.
The bank also disclosed that it is being investigated by the US Securities and Exchange Commission (SEC) in relation to the hiring of people referred by, or related to, government officials or employees of state-owned companies in Asia Pacific.
The SEC is already investigating JP Morgan over its employment of so-called princelings - the offspring of influential figures in the Chinese government and the country's elite. Goldman Sachs is also under investigation for its hiring practices in the region.
HSBC said: "HSBC has received various requests for information and is cooperating with the SEC's investigation.
"Based on the facts currently known, it is not practicable at this time for HSBC to predict the resolution of this matter, including the timing or any possible impact on HSBC, which could be significant."
The relatives of China's government officials are permitted to engage in business but are not allowed to profit from their connections.
HSBC's annual report also revealed that a monitor appointed by the US government to assess the bank's anti-money laundering and sanctions compliance programme had expressed "significant concerns" about the progress of improvement.
In 2012, HSBC was fined $1.9bn for failing to stop "drug kingpins and rogue nations" from using the bank to launder money.
As part of a five-year deferred prosecution agreement, HSBC agreed to allow a monitor to track its progress on putting in place certain compliance measures.
However, the monitor, Michael Cherkasky, found instances of potential financial crime as well as systems and controls deficiencies in the last year.
Mr Cherkasky, a former New York prosecutor, also questioned whether HSBC was on track to meet its five-year target to tighten money laundering controls.
HSBC recently announced that the bank would keep its headquarters in the UK, where they have based since 1993.
After a ten-month long investigation, HSBC said it had decided unanimously against the move and that London offered "the best outcome" for its shareholders and customers.
Mr Gulliver insisted that the bank would not review the location of its headquarters if Britain voted to leave the EU.
He added that if there was an exit, he only expected it to affect its 5,000-person global banking and markets business in the UK and forecast that 1,000 staff with roles linked to European financial legislation would have to move to Paris.
HSBC is understood to have paid about Â£30m to advisors to help it reach the decision, which was was seen as a vote of confidence for the UK.
However, some analysts said the decision to stay in London was not a good one because it meant HSBC would face tighter regulations together with the cost of the UK bank levy.
Economics editor Kamal Ahmed: Sigh of relief as HSBC stays in UK
HSBC chairman Douglas Flint on the banking giant's decision to keep its headquarters in London.
HSBC to axe up to 25,000 jobs globally in savings drive.
London-listed shares in HSBC have fallen 16% in the year-to-date and more than 25% over the last 12 months.
Last year, the bank announced thousands of job cuts, along with asset sales, as part of a major cost-cutting plan.
The lender has a global network of more than 6,000 offices in 72 countries and territories and serves some 48 million customers, according to its website.


Portugal's parliament has passed an austerity budget to cut the country's high debt levels, after the opposition upheld an agreement with the minority government to abstain from voting.

The budget provides for measures to cut the deficit from 7.3% of economic output this year to 4.6% in 2011.
It will cut public spending and raise VAT - measures that have proved very unpopular with voters.
Prime Minister Jose Socrates threatened to quit if the budget failed.
The opposition Social Democrats oppose tax rises, preferring spending cuts, but agreed last week to abstain from voting.
Confidence in Portugal's economy was hit hard over the summer during the eurozone debt crisis.
The rate of interest that the government had to pay to investors in order to borrow money, in part to service existing debt, rose sharply.
This led a number of leading credit rating agencies to downgrade Portuguese government debt, compounding the problem.
There were fears that if the austerity budget had not been passed, the cost of borrowing would again increase dramatically.
A number of countries have announced measures to reduce budget deficits that rose dramatically during the economic downturn, most notably Greece and the UK.


Tarantulas have evolved almost exactly the same shade of vibrant blue at least eight separate times.

That is the conclusion of a study by US biologists, exploring how the colour is created in different tarantula species.
The hue is caused by tiny structures inside the animals' hairs, but those shapes vary across the family tree.
This suggests, the researchers say, that the striking blue is not driven by sexual selection - unlike many other bright colours in the animal kingdom.
This argument is also supported by the fact that tarantulas have poor colour vision, and do not appear to show off their hairy blue body parts during courtship.
Nonetheless, Bor-Kai Hsiung and his colleagues found that 40 out of 53 groupings (genera) of tarantula exhibit a very vibrant blue.
"We collected published data and constructed a super-tree, which combined the previous published small trees," said Mr Hsiung, a PhD student at the University of Akron in Ohio and the first author of the study, published in Science Advances.
They then mapped blueness onto that evolutionary tree, based on a bank of tarantula snaps scoured from the internet.
"If the genus has at least one species that's blue, we say that's a blue genus," Mr Hsiung explained.
Given that scattering of blue species, he added, they then calculated "the lowest number of changes that can produce a distribution of blue colouring like this".
The answer? "Eight is the lowest number, so it's [evolved] at least eight times."
What is more, all these blue spiders evolved almost precisely the same shade; the wavelengths the team saw in the images all fell within a tight 20 nanometre range, clustered around 450nm - a bright, cobalt blue.
The team also purchased specimens of eight tarantula species, and took a close look at those blue hairs.
They used electron microscopes to zoom in on tiny shapes within the hairs and conducted simulations of how those shapes could produce a "structural colour" by reflecting - very specifically - this wavelength of blue light.
The results, again, pointed to the colour cropping up multiple times independently: several different types of shape could be seen, even on the same branch of the family tree.
"That's one of the reasons why it must have evolved so many times - because we don't see a very clear pattern of how these different mechanisms split," Mr Hsiung said.
"If we could see a clear split, then it might have evolved just one or two times. But it's all over the place."
So why did all these different species acquire the same colour?
Given their relatively simple eyes, it is doubtful that tarantulas can distinguish this shade of blue from any other colour.
That is one of the reasons that sexual selection seems unlikely - by contrast with some other spiders, which have remarkably good vision and put on very colourful courtship displays, such as the mesmerising peacock spider.
"It evolved from multiple origins and different mechanisms produce the very same blue colour," Mr Hsiung said. "That's very strong evidence to suggest that this blue colour has a very important visual signalling function.
"But if it's not for other tarantulas, then it must be to some other receivers out there."
It may be that this colour helps conceal the critters from their prey while they hunt at night; or perhaps it serves as a warning to stop the tarantulas themselves being eaten.
"We don't know yet," Mr Hsiung said.
Follow Jonathan on Twitter


The average cost of everyday household goods and services went up by 0.5% in the year to June.

The UK inflation rate, as measured by the Consumer Prices Index (CPI), rose from 0.3% in May, official figures show.
The Office for National Statistics (ONS) attributed the rise to higher air fares, fuel and consumer spending.
Much of that was the result of European air travel, possibly connected to the Euro 2016 football tournament, it said.
The inflation figures are based on data collected before the EU referendum vote on 23 June.
The cost of flights jumped by a record 10.9% between May and June, ONS statistician Phil Gooding said.
"The growing cost of oil, feeding through to petrol prices, also helped to nudge up CPI," he added.
City analysts expect inflation to rise sharply in the coming months as the fall in the pound relative to other currencies following the Brexit vote makes goods imported into the UK more expensive.
The 0.5% annual increase in CPI matches that in March this year. It was last higher in November 2014.
But this measurement of the cost of living has remained well below the Bank of England's 2% target for more than two years.
The weaker pound has also raised expectations that the Bank of England will look to cut interest rates in August to combat a possible slowdown in economic growth, as increased costs feed into the wider economy and impact on consumer spending and confidence.
The Bank will release its quarterly inflation forecasts next month, which are expected to include an analysis of the impact of the UK's vote to leave the EU.
But the cut in interest rates could be short-lived, as some economists have forecast inflation could peak as high as 5% next year.
That might force the Bank to raise interest rates sharply in order to bring inflation back under control.
Earlier this month Bank of England governor Mark Carney, giving evidence to the Treasury select committee, warned that homeowners should be prepared for a 3% rise in interest rates.
Chris Williamson, chief economist at IHS Markit, said the rise in inflation was "likely to be the start of a rising trend in prices as costs march higher in response to the recent slump in sterling."
He added inflation was likely to rise further in coming months as the impact of sterling's depreciation feeds through, "breaching the Bank of England 2% target next year, possibly by some margin".
However, policymakers are expected to 'look through' any rise in inflation caused by the Brexit-related slump in the pound, focusing instead on the job of shoring up economic growth, he said.


Only five local authorities in Wales have rehoused Syrian refugees, despite all 22 pledging to do so.

Home Office figures show Wales resettled 78 Syrian refugees between October 2015 and March while Scotland accepted more than 600.
Charities said the figures were "disappointing" and Wales "should step up to the plate".
The Welsh Local Government Association (WLGA) said more councils were at the ready and it was in active discussions.
Carys Mair Thomas, head of Oxfam Cymru, said: "What is stopping all local authorities from welcoming these families?
"Ceredigion has become a trailblazing Welsh council despite never previously welcoming refugees, and should encourage others, with far more experience in these matters, to step up to the plate."
Neath Port Talbot welcomed the most so far, 27, followed by Swansea with 24. Torfaen and Ceredigion took in 10 each, and Caerphilly seven.
In May, Wrexham agreed to take in five Syrian families, while in April, Anglesey also agreed to accept 10 families over the next three years.
All Welsh councils have committed to take part in the Home Office-funded scheme, which will resettle 20,000 displaced Syrians living in refugee camps in the UK by 2020.
In September 2015, First Minister Carwyn Jones called for more leadership on the refugee crisis, and indicated Wales would accept 500 to 600 refugees.
A total of 1,602 arrivals have been welcomed across the UK.
Oxfam said for Wales to meet its fair share, each council only needed to welcome fewer than 10 families each.
A WLGA spokesman said councils were dealing with "challenging reception and resettlement issues".
"A number of Welsh councils have already played their part. More are standing at the ready and will receive refugees later this year.
"We are confident Welsh authorities will play a full role in the next stage of a UK-wide Syrian refugee resettlement programme that is being coordinated by the Home Office."
A Home Office spokesman said local authorities signed up to the the scheme on a voluntary basis.
He said councils were asked to "think very carefully" about whether they have the infrastructure and support networks needed to ensure the "appropriate care and integration of these refugees" before telling the Home Office how many refugees they are able to accept.


Nine summer Olympics, nine Commonwealth Games, every World Championships since its inception in 1983 and all the 37 runnings of the London Marathon.

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Brendan Foster's commentary career, which has spanned almost 40 years and borne witness to some of the greatest moments and athletes in history, is coming to an end after next month's World Championships.
The 69-year-old, who competed for Great Britain at three Olympics before taking up the microphone, picks out the highlights of his commentary career.
"Recently, clearly, my favourite has been Mo Farah, the winner of an unprecedented set of medals at the very highest level.
"During the middle of my career, it was Ethiopian great Haile Gebrselassie.
"And at the beginning of my career it would have been Seb Coe."
"The best performance I ever commentated on was Haile Gebrselassie winning the 10,000m at the 2000 Olympic Games in Sydney.
"He hadn't trained for three or four weeks beforehand because of an injury.
"The rest of the field did not know and Kenya's Paul Tergat, who was arguably the fastest in the world at the time, did not take advantage.
"Gebrselassie should never have won that race but he did because he just had not learned how to lose.
"He was not fit enough to win, but he dug it out and did not show anyone that he was in pain.
"He could not run a lap of honour at the end, he had to walk it instead. He didn't run again that year.
"It was a heroic performance, that is why it stands out in my memory."
"Mo Farah winning in the 10,000m in London 2012 was the most exciting race I have seen.
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"Could this guy, who hadn't even made the final in 2008, really deliver on the form he had showed and win gold in front of a home crowd?
"He could."
"In the Great North Run in 2013 we had Mo Farah, Haile Gebrselassie and Kenenisa Bekele -  three greatest athletes of all time - competing in the race I had founded, running past Gateshead Stadium where I had made my name by breaking the 3,000m world record in 1974.
"The combination of those three elements made for a very emotional moment."
"London 2012, an event that will never be forgotten."
"It was 1985 and Steve Jones and Charlie Spedding were running neck and neck, one and two, at the London Marathon.
"At that time we did not have many cameras. We switched from a shot of the two of them together to a brass band playing near the Cutty Sark.
"When we cut back, Charlie was running on his own with Steve out of shot.
"Next time we saw Steve he was rubbing his hamstring and I said to my co-commentator David Coleman, 'it looks like Steve Jones has had to stop because of a cramp'.
"David, noticing that Steve was cleaning his leg rather than rubbing his muscles, said 'I think you have got one letter wrong there.'"
"It is the privilege of translating my thoughts and views on something I love to the most knowledgeable athletics audience in the world.
"The BBC athletics audience have been watching the sport since the four-minute mile 60-odd years ago.
"That is a privilege I'll miss."
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Nintendo has announced its first smartphone 'game', but delayed its launch from the end of the year until next March.

As some predicted, it was not a Super Mario game, but "Miitomo", an app in which players create their own avatars to talk to each other.
The company's share price fell as much as 10 percent on the news.
But one analyst said it was a typically cautious and prudent first step into smartphone gaming from Nintendo.
Nintendo said that Miitomo would be a "free-to-start communication application". Players would create their own Mii avatars, which they could use to chat to other players, it said at a launch event in Tokyo on Thursday. It will also reportedly feature in-app purchases.
The features have more in common with a social network than a traditional Nintendo game.
Miitomo was designed as an introduction to Nintendo's other, yet to be announced, smartphone gaming efforts, the firm said, adding that it planned to have five apps ready by the end of March 2017.
"Miitomo is exactly in line with how Nintendo should be approaching mobile. It is the ideal toe-dip for the company and its fans," said mobile expert Steve Bailey, of IHS Analysis.
"The first thing people did on the Wii and 3DS was to create a personal, social presence. This is Nintendo replicating that for mobile.
"I don't expect it to be a rousing stand-alone success. This is an exploratory effort and one whose role will be complementary to a broader catalogue of games going forward," he added.
According to the Agence France-Presse news agency, Nintendo's new president Tatsumi Kimishima said the firm needed more time to "boost the quality" of its first smartphone offering. After initially dropping 10%, Nintendo's stock price rallied to close 8.97% down at 20,945 yen (Â£113.46, $173.12).
Shares in the mobile gaming company DeNA, with which Nintendo developed the game, fell nearly 15% to 2,080 yen.
According to Mr Bailey, investors would be well advised to recognise that Nintendo's strength is its intellectual property, such as the Super Mario series of games. Its track record, he said, suggested that the more popular series will be brought to smartphones once the company has gained experience on the platform.
"Hardware is transitory. Despite any near-term market grumbles, the greatest risk Nintendo faces is diluting that IP. Anyone expecting a Super Mario freemium game before the year is out, will probably need to throttle those hopes," he said.
"Nintendo has the potential to carve itself a unique and profitable position on mobile, but the journey there may frustrate those investors expecting immense, immediate success. Having to navigate those expectations while preserving the value of its IP, is going to be the key challenge for Nintendo in mobile."
In a statement, Nintendo said it would "consider any and all Nintendo IP as candidates for future apps".


A man arrested over a group sex attack on a teenager in a Harrogate park has been released on bail.

The 14-year-old girl was grabbed by three men and pulled into the town's Grade-II listed Valley Gardens at about 04:00 GMT on Tuesday, police said.
Detectives arrested a man on Wednesday in connection with the assault, which happened near Harlow Moor Drive.
He was said to have been helping North Yorkshire Police with their inquiries and has since been released.


A High Court judge has dismissed a bid for a judicial review into Sheffield City Council's tree felling programme.

The Streets Ahead scheme has seen more than 3,000 trees replaced since 2012.
Campaigners claim they were not properly consulted about it and successfully applied for a temporary injunction to stop felling, but this was later overturned.
The council said the scheme is to remove dead, diseased or dangerous trees from roadsides in the city.
The Labour-run authority said the programme, being carried out by contractor Amey, was essential if Sheffield's 36,000 street trees are to be managed for future generations.
David Dillner, who lives in the city, took legal action and claimed the council failed to assess the environmental impact of the felling.
Delivering his ruling, Mr Justice Gilbart said Mr Dillner's claim was "in truth devoid of merit".
He said his job had been to determine the legal merits of Mr Dillner's High Court action and added: "Nothing in this judgment is to be read as criticising the residents of Sheffield for seeking to protect the trees in their streets and roads whose presence many of them appreciate so much."
Mr Gilbart said the council was required to maintain roads and streets and it was "unfortunate in the extreme" that the objectors "failed to address both sides of the argument".
The judge said Mr Dillner must pay Â£5,000 of the legal costs run up by the council, as well as footing his own lawyers' bills.
Mr Dillner said he was "extremely disappointed with the court's decision".
"My legal team does not accept the strident criticism in the judgement and will be appealing the decision to the Court of Appeal before the end of this week," he said.
"I will be seeking the council's immediate assurance that it will not recommence felling until the Court of Appeal has considered whether to grant permission for my appeal to be heard."
Simon Green, of Sheffield City Council, said: "The decision demonstrates that we have been right to say we are following best practice guidance and working hard in the best interests of the city."


Bradford maintained their unbeaten start to the season with victory over managerless Shrewsbury at Valley Parade to stay second in League One.

Nicky Law fired the hosts in front after 21 minutes, drilling home from 10 yards after a Filipe Morais shot had been blocked by Abu Ogogo.
It was the midfielder's first goal since joining the Bantams from Rangers in the summer and the ninth game in a row when Shrewsbury have conceded first.
Morais went close to a second in Bradford's next attack but some last-ditch defending from Jack Grimmer managed to deflect the ball over the crossbar.
Bradford were not so effective after the break and Shrewsbury had a strong penalty shout for handball against defender Stephen Darby.
Goalkeeping coach Danny Coyne, in temporary charge of Shrewsbury following manager Micky Mellon's resignation to join Tranmere, saw his team threaten more as the game went on.
But substitute Haris Vuckic secured Bradford's win with a stoppage-time penalty after Antoni Sarcevic brought down Daniel Devine.
Reports supplied by the Press Association.
Match ends, Bradford City 2, Shrewsbury Town 0.
Second Half ends, Bradford City 2, Shrewsbury Town 0.
Goal!  Bradford City 2, Shrewsbury Town 0. Haris Vuckic (Bradford City) converts the penalty with a left footed shot to the bottom right corner.
Penalty Bradford City. Daniel Devine draws a foul in the penalty area.
Penalty conceded by Adam El-Abd (Shrewsbury Town) after a foul in the penalty area.
Abu Ogogo (Shrewsbury Town) is shown the yellow card for a bad foul.
Mark Marshall (Bradford City) wins a free kick in the defensive half.
Foul by Abu Ogogo (Shrewsbury Town).
Attempt missed. George Waring (Shrewsbury Town) header from the centre of the box is just a bit too high.
Substitution, Shrewsbury Town. Andy Mangan replaces Ian Black.
Attempt blocked. George Waring (Shrewsbury Town) right footed shot from the centre of the box is blocked.
Foul by Daniel Devine (Bradford City).
Ian Black (Shrewsbury Town) wins a free kick in the attacking half.
Substitution, Bradford City. Haris Vuckic replaces Billy Clarke.
Corner,  Bradford City. Conceded by Jack Grimmer.
Attempt blocked. James Meredith (Bradford City) right footed shot from the left side of the box is blocked.
Attempt missed. Billy Clarke (Bradford City) header from the centre of the box is just a bit too high.
Attempt blocked. Nicky Law (Bradford City) right footed shot from the left side of the box is blocked.
Corner,  Bradford City. Conceded by Joe Riley.
Timothee Dieng (Bradford City) wins a free kick on the right wing.
Foul by Antoni Sarcevic (Shrewsbury Town).
Substitution, Bradford City. Marc McNulty replaces Jordy Hiwula-Mayifuila.
Attempt blocked. Nicky Law (Bradford City) right footed shot from the left side of the box is blocked.
Jack Grimmer (Shrewsbury Town) is shown the yellow card for a bad foul.
Jordy Hiwula-Mayifuila (Bradford City) wins a free kick on the left wing.
Foul by Jack Grimmer (Shrewsbury Town).
Attempt blocked. Joe Riley (Shrewsbury Town) right footed shot from outside the box is blocked.
Timothee Dieng (Bradford City) wins a free kick in the attacking half.
Foul by Ian Black (Shrewsbury Town).
Attempt missed. Jordy Hiwula-Mayifuila (Bradford City) left footed shot from the left side of the box is close, but misses to the left.
Attempt missed. Adam El-Abd (Shrewsbury Town) header from the centre of the box is close, but misses to the left.
Corner,  Shrewsbury Town. Conceded by Nathaniel Knight-Percival.
Substitution, Shrewsbury Town. Mat Sadler replaces Junior Brown because of an injury.
Foul by Billy Clarke (Bradford City).
Joe Riley (Shrewsbury Town) wins a free kick in the attacking half.
Attempt missed. Antoni Sarcevic (Shrewsbury Town) right footed shot from outside the box is just a bit too high.
Substitution, Bradford City. Daniel Devine replaces Filipe Morais because of an injury.
Mark Marshall (Bradford City) wins a free kick in the attacking half.
Foul by Antoni Sarcevic (Shrewsbury Town).
Jordy Hiwula-Mayifuila (Bradford City) is shown the yellow card for a bad foul.


The clinical trial of an Ebola vaccine in Switzerland has been interrupted after some patients complained of joint pains in their hands and feet.

The trial was stopped one week early in all 59 volunteers "as a measure of precaution", the University of Geneva Hospital said.
The vaccine being tested is one developed by NewLink, and recently bought by Merck.
There is currently no vaccine licensed for use to protect against Ebola.
Two vaccines are currently being tested in humans in a number of countries.
The side-effects in the Geneva trial were experienced by four volunteers.
The hospital said human safety trials would resume on 5 January in up to 15 volunteers after checks had taken place to ensure the joint pain symptoms were "benign and temporary".
"They are all fine and being monitored regularly by the medical team leading the study," the hospital said.
Four trials of another Ebola vaccine developed by GlaxoSmithKline, in collaboration with the United States National Institute of Allergy and Infectious Diseases, are also underway.


The US Secret Service has released new details of last week's White House fence-jumping incident, in which an intruder was discovered just steps from the main building.

Jonathan Tran, 26, was in the grounds for more than 16 minutes before he was detained, it said.
He now faces a maximum sentence of 10 years in prison.
In a statement, the Secret Service said it was "extremely disappointed and angry" about the events of 10 March.
Mr Tran did not gain entry to the White House, where President Donald Trump was staying at the time.
However, Congressman Jason Chaffetz - whose House Oversight Committee oversees the Secret Service - claimed the intruder had managed to rattle a door-handle at the South Portico entrance.
According to court documents, Mr Tran told federal agents that he was a friend of the president and had an appointment.
He was carrying two cans of mace, a US passport, a computer and one of Mr Trump's books, authorities said.
The president praised the Secret Service for doing a "fantastic job" in apprehending the intruder.
Mr Tran had managed to climb a 5ft (1.5m) fence near the US Treasury Department, which is next to the White House. He then scaled an 8ft vehicle gate, and a shorter fence near the east wing of the White House grounds.
CNN reports that he set off several alarms after jumping the fence, but was able to avoid other sensors.
Mr Tran, who comes from Milpitas, California, had reportedly been spotted "looming around" Washington's Pennsylvania Avenue, where the White House stands, nearly six hours before his arrest.
The Secret Service said it had taken immediate steps to avoid further security lapses, and that over 50 people had been interviewed about the incident.
The intrusion was the latest in a series of breaches at the White House in recent years.
Security has been enhanced. In 2015, sharp spikes were installed on top of the black iron fence that circles the property.


Warren Gatland hopes the power of "frustration" can inspire Wales to a third successive post-World Cup Grand Slam.

Gatland won a first clean sweep in his maiden Six Nations as coach in 2008 after Wales' disappointing 2007 World Cup display.
He guided Wales to a second Grand Slam in 2012 after narrowly missing out on the 2011 World Cup final.
"We were disappointed not getting to the final in 2011," he said.
"We feel a little bit the same this time around.
"There's a little bit of frustration as we felt we could have gone a bit further in the World Cup, although we were proud of what we achieved given the number of injuries we had."
Wales qualified alongside Australia from their World Cup pool despite a host of injuries to key players such as Leigh Halfpenny, Jonathan Davies and Rhys Webb.
Wales were knocked out of the World Cup by two-time champions South Africa in the quarter-final despite leading with 10 minutes remaining.
Webb and Halfpenny are still out injured, but centre Davies has returned while backs Liam Williams and Hallam Amos are returning to fitness.
Wales hold the record of Championship victories - 26 outright and 12 shared - and a third Grand Slam in nine years would mean they join England on a record 12 Grand Slams.
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Ireland are bidding to become the first side ever to win the Championship three times in a row and Wales coach Gatland said: "You can't look past the Irish."
The New Zealander also said that England under new coach Eddie Jones are an "unknown quantity" in "a really open competition".
Wales begin their Six Nations bid against the defending champions in Dublin - the same venue where the Welsh began their 2012 Grand Slam campaign.
"We're in pretty good shape," added Gatland, himself a former Ireland coach.
"There's a few new coaches this year and the familiarly will help us put things together quickly.
"Our time together at the World Cup is invaluable preparation and potentially a slight advantage.
"It is massive that we're going away to Dublin first and if we can win that first game, the next game at home against Scotland is six days later.
"Momentum is huge in this competition."


Williams have launched their new car for 2017 in low-key fashion before pre-season testing in Barcelona.

The team, who have made mainly cosmetic changes to the car, have tempted driver Felipe Massa to come out of retirement after Valtteri Bottas joined Mercedes.
Massa is joined by Canadian rookie Lance Stroll, 18, son of billionaire businessman Lawrence Stroll.
Williams will be looking to reassert themselves after finishing fifth in the constructors' table last season.
"Although cosmetically the 2017 cars will look very different to their 2016 predecessors, the core of the car, the power unit and the areas situated around the power unit, have not changed a great deal," Williams said in a statement.
The new car will take to the track for the first time during a pre-season test, which will start with Brazilian Massa driving it in Spain on Monday, 27 February.
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BBC Sport chief F1 writer Andrew Benson
The challenge for Williams this year is to at least hold on to their fifth place in the constructors' championship, and try to ensure they don't slip back further after falling two places in 2016.
The new car looks clean enough but it appears among the more conservative so far. The rear packaging, for example, is nowhere near as tight and sophisticated as that on the Mercedes, with which the Williams shares an engine.
The driver line-up, too, raises questions.
Felipe Massa was tempted back out of retirement to replace Mercedes-bound Valtteri Bottas. There is no question over his motivation - he didn't really want to retire. But he gives away some performance to the best.
And Lance Stroll is an unknown quantity. European Formula Three champion and bringing millions to Williams through billionaire father Lawrence, but with an awful lot to prove.


The Scottish government is still without a chief scientific adviser, a year after the previous post-holder left the job.

It has been empty since Glasgow University academic Prof Muffy Calder stepped down in December 2014.
The position involves giving independent scientific advice to ministers on a range of issues.
Ministers said they had already committed to advertising the job by the end of the year.
The post of chief scientific adviser (CSA) was previously advertised between March and April this year, but the government was unable to appoint a successor.
The issue had also delayed the replacement of several members of the Scottish Science Advisory Council - including the chairman - whose terms of office ended earlier this year.
Their recruitment had been put on hold pending appointment of a new CSA, however, the government subsequently decided to move ahead with the process, and interviews are being held this week.
Science advice
In the last 12 months, the Scottish government has announced a moratorium on fracking and underground coal gasification, a ban on growing GM crops and has played a key role in the recent international climate change talks in Paris.
All are issues in which a chief scientific adviser may have provided advice to ministers.
Earlier this year, Prof Calder said the government's GM crops decision could have "apocalyptic" consequences and threaten the country's food and drinks industry.
Her views have been echoed by another former chief scientific adviser for Scotland, Dame Anne Glover.
The Scottish government said in September that it would advertise for a new chief scientific adviser, after asking for help from university principals and others to fill the post.
A government spokesperson said: "In the meantime, the remaining chief scientists, covering health and rural affairs, food and the environment, continue to carry out key tasks that would usually be done by the CSA Scotland.
"The Scottish government remains committed to drawing on the very best science advice and expertise."
Ministers said they hoped to announce the new members and chairman of the Scottish Science Advisory Council "early in 2016".


Exchanges of fire are continuing at a hotel in Burkina Faso's capital as special forces seek to break a deadly siege by suspected Islamist gunmen.

Some 30 hostages were freed overnight at Ouagadougou's luxury Splendid Hotel but there are fears that at least 20 people were killed.
Gunmen stormed the hotel and a nearby cafe after setting off bombs.
Al-Qaeda in the Islamic Maghreb (AQIM) has said it carried out the attack in the West African nation, monitors said.
French President Francois Hollande - whose forces are part of the operation against the militants - condemned the "odious and cowardly attack".
Remi Dandjinou, the Burkinabe communications minister, told the BBC there were between six and seven gunmen and they had been staying at the hotel.
He also said a member of the government, Minister of Public Works Clement Sawadogo, was among those freed at the hotel.
Thirty-three people were in hospital receiving treatment, he added.
French special forces and Burkinabe troops have been deployed at the hotel, which is used by UN staff and Westerners.
Hospital chief Robert Sangare quoted survivors as saying at least 20 people had died in the initial attack, before the security forces began their assault on the hotel.
Interior Minister Simon Compaore said 10 bodies had been found on the terrace of the nearby Cappuccino cafe.
The al-Murabitoun group, which reportedly merged with AQIM recently, was involved in the attack, monitors said.
Who are al-Murabitoun?
Witnesses said the gunmen had initially entered the Cappuccino cafe. One employee at the cafe told AFP news agency "several people" had been killed there.
Eyewitnesses reported hearing exchanges of gunfire between the men and security forces, as well as sporadic gunfire from inside the hotel, which is close to the country's international airport.
The SITE monitoring group, which analyses jihadist networks, reports that al-Qaeda in the Islamic Maghreb (AQIM) has said it was behind the attack.
The monitoring group specifically stated that those responsible were the al-Murabitoun group, which is based in the Sahara desert in northern Mali and contains fighters loyal to the veteran Algerian militant Mokhtar Belmokhtar.
Last month, the group announced it had merged with AQIM. Belmokhtar, a one-eyed commander who fought Soviet forces in Afghanistan in the 1980s, was once a member of AQIM but left after a falling-out with its leadership.
Belmokhtar has been declared dead many times, the latest by a US air strike on 14 June last year in Libya - according to Libyan authorities - but his death has not been formally confirmed.
AQIM and al-Murabitoun said they were behind an attack on a hotel in Burkina Faso's neighbour Mali in November, that left 20 people dead.
Burkina Faso had recently held its first presidential election since a coup earlier last year.
That coup toppled long-time leader Blaise Compaore, who had governed for 27 years.
"We are still in a context of political fragility, so I think the timing of this attack is meaningful," Cynthia Ohayon, an analyst with the International Crisis Group, told the BBC from Ouagadougou.
"The country has long borders with Mali and Niger, and we know there are armed groups present on the border, so this was probably something we had coming."
In November, an AQIM attack on a hotel in the Malian capital Bamako left 19 people dead.
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Among the thousands who lined the streets of London to witness the funeral procession of Baroness Thatcher was a self-confessed "Essex Man" who has a picture of the former prime minister in his bedroom.

Bill Sharp, 65, was the the son of a unionised stevedore who loaded and unloaded the ships at the East End's Royal Albert docks.
He left grammar school at the age of 15 wanting something more.  And he got it - a career in the City and the trappings which come with it.
Now living in Hadleigh near Southend, he continues to run his stockbroking firm and work as a consultant.
For Mr Sharp, taking his place outside St Paul's Cathedral to say a final farewell was a foregone conclusion.
He allowed BBC News to join him on his journey from Essex to central London as Margaret Thatcher was his political inspiration.
"She means a great deal to me," he said. "It was in about 1970 that I started to recognise her.
"I became a councillor back in 1978 based on listening to her.
"She wasn't the first woman prime minister to me, she was the leader of our party and she did a wonderful job."
Their paths were to cross a number of times.
Mr Sharp made three visits to Downing Street during her tenure, enjoyed a dinner in her company (with others) and was at the Conservative Party conference in 1984 at Brighton's Grand Hotel when five people were killed and 31 were injured.
An aspiring politician, Mr Sharp had put his name down to speak on five different subjects. He ended up speaking about the community charge (often referred to as the poll tax) - the subject he had prepared least for.
But it was the speech the prime minister delivered the day after the bomb that he remembers most vividly.
"The speech was magnificent. There was an explosion of support for her," he said.
"I am delighted to be able to say that I met her, shook her hand, listened to her and was told off by her, and followed her principles through my life."
Mr Sharp is proud of the parallels between his own humble upbringing and those of Margaret Thatcher, the grocer's daughter.
He said: "She was wealthy compared with my family roots.
"My father was a union man, I understand unionism but I didn't find socialism the answer. If you go out and work, you can contribute to your family."
While the then Margaret Roberts lost out when she contested the parliamentary seat of Dartford in the 1950 and 1951 general elections, Mr Sharp unsuccessfully fought the Barking seat just across the Thames in 1987.
His campaign slogan was simple: "She trusts him, why don't you?" The she, of course, was Baroness Thatcher.
Since then, Mr Sharp has focused on local politics and continues to serve on Castle Point Borough Council.
He said: "I will be standing there with sympathy in my heart, and gratitude for what she did for this nation, for what she did for me personally and for what she did for the party.
"People either loved her or hated her. A bit like me."


Christian Atsu has been left out of the 30-man Ghana squad for next month's Africa Cup of Nations qualifier against Ethiopia.

The 25-year-old forward is one of several high-profile players omitted by Kwesi Appiah in his first squad since his second coming as Black Stars coach.
Atsu, who signed for newly-promoted English Premier League side Newcastle United this week, is joined on the sidelines by Mubarak Wakaso, Emmanuel Agyemang-Badu and Razak Brimah.
No official explanation has been given for the decision to drop Atsu, Wakaso, Badu and Brimah but Appiah has made it clear that he will cast his net far and wide in search of new talent to take Ghana forward.
Appiah has included seven players from the domestic league in a squad that will also play friendly internationals against the United States and Mexico.
Abdul-Majeed Waris, the striker overlooked by former coach Avram Grant for the 2017 Africa Cup of Nations finals in Gabon, has been given a chance to revive his international career as a Black Star.
Appiah has also kept faith with regulars such as captain Asamoah Gyan and the Ayew brother, Andre and Jordan.
The Nations Cup qualifier against Ethiopia will take place on 11 June in the second city of Kumasi.
The Black Stars will travel to the US for a date with Mexico in Houston, Texas, on (28 June) and the US in Connecticut (1 July).
Goalkeepers:
Richard Ofori (Wa Allstars); Adam Kwarasey (Brondby, Denmark); Felix Annan (Kotoko); Joseph Addo (Aduana Stars)
Defenders:
Harrison Afful (Columbus Crew, USA); Daniel Amartey (Leicester City, England); Lumor Agbenyenu (Munich 1860, Germany); Daniel Darkwah (Aduana Stars, Ghana); John Boye (Sivasspor, Turkey); Rashid Sumalia (Al Gharafa, Qatar); Nicholas Opoku  (B.Chelsea, Ghana); Jonathan Mensah (Columbus Crew, USA); Jerry Akaminko (Eskiserhispor, Turkey); Samuel Sarfo (Liberty, Ghana)
Midfielders:
Mohammed Abu (Columbus Crew, USA); Afriyie Acquah (Torino, Italy); Isaac Sackey (Alanyaspor, Turkey); Thomas Partey (Atletico Madrid, Spain); Ebenezer Ofori (Stuttgart, Germany); Kingsley Sarfo (Sirius, Sweden); Winful Cobbinah (Hearts of Oak); Yaw Yeboah (FC Twente, Holland);  Godsway Donyoh (Nordjaelland, Denmark); Andre Ayew (West Ham, England); Frank Acheampong (Anderlecht, Belgium); Thomas Agyepong (NAC Breda, Holland)
Forwards:
Asamoah Gyan (Al Alhi, UAE); Jordan Ayew (Swansea City, England);  Majeed Waris (Lorient FC, France); Raphael Dwamena (FC Zurich, Switzerland)


The jailed Mexican drug lord, Joaquin Guzman, has asked to be extradited to the United States rapidly so he can receive better treatment in prison.

His lawyer said Guzman had asked him to stop fighting his extradition because guards at his prison would not let him sleep.
"El Chapo" Guzman was recaptured in January, six months after he escaped from prison.
Prison authorities say he is woken and checked every four hours.
Two US courts have requested Guzman's extradition on charges of drug trafficking in California, and murder in Texas.
But Guzman's defence teams filed an estimated nine appeals against his extradition.
Guzman's lawyer, Jose Refugio Rodriguez, said his client had told him to negotiate with the US authorities for a lighter sentence and confinement at a medium-security prison.
Speaking on a Mexican radio station, Radio Formula, he said: "He has reached his limit, it is an act of desperation."
Guzman escaped down a 1.5 km (1 mile) tunnel from the Altiplano maximum security prison outside Mexico City and was on the run for six months.
He was returned to the prison in January but to a much harsher regime.
Mr Rodriguez said his client was now kept isolated and segregated and complains his cell is small, cold and he does not see the sun.
Previously, Guzman said he had been given an hour-and-a-half every day to talk to his lawyer and an hour in the prison patio.
Every nine days, he had been allowed a four-hour conjugal visit and a four-hour family visit.
Mr Rodriguez said it would take two months to organise his extradition to the US.


(Open): Shares on London's main index were flat in early trading.

The FTSE 100 index was down by just one point at 6,567.35.
Mining firm Glencore was the biggest faller, down 1.9% while chip maker Arm Holdings was the best performer, up 2.8%.
Overnight, China's central bank increased the range in which its currency, the yuan, could trade, allowing it to strengthen, after three days of falls.
Earlier this week China devalued the currency sparking falls on stock markets.
On the currency markets, the pound rose 0.01% against the dollar to $1.56120 and climbed 0.4% against the euro to â‚¬1.40004.


Republican Donald Trump has said he would easily beat Democratic rival Hillary Clinton in a presidential contest for the White House.

The businessman with no political experience convincingly won the New Hampshire primary and has now laid out his strategy to go all the way.
Elsewhere, Republican Carly Fiorina has announced she is dropping out of the race after getting just 4% of the vote.
South Carolina is next in the state-by-state contest to be Republican pick.
In the Democratic race, Nevada provides the next challenge, with Vermont Senator Bernie Sanders keen to carry on his momentum after a stunning victory over Mrs Clinton in New Hampshire.
But Mr Trump dismissed him as an unlikely nominee because of his proposed tax increase, and focused instead on the former secretary of state and first lady.
"Polls are showing that I will beat Hillary Clinton easily," he told CBS on Wednesday morning, before outlining his strategy to win states that traditionally have backed Democratic presidential candidates.
"I have a chance of winning New York. You know, you look at these politicians they always talk about the six states - you've got to win this one, that one. You have to win Ohio, you have to win Florida.
"I can change the game because I really have a chance of New York, I'm going to win Virginia. I'm going to win Michigan, as an example."
Latest news and reaction
Trump turns notoriety into a win
Winner and losers from New Hampshire
What would a Trump presidency be like?
How primaries and caucuses work
He denied he was unstoppable in the race to win the Republican nomination, however, and paid tribute to his friend New Jersey Governor Chris Christie, who is subject to speculation he may drop out after a poor showing in New Hampshire.
"I thought he was very effective. And I was surprised he didn't do better," said Mr Trump.
Later on Wednesday, another Republican candidate, Carly Fiorina announced on Facebook her decision to exit the race: "While I suspend my candidacy today, I will continue to travel this country and fight for those Americans who refuse to settle for the way things are and a status quo that no longer works for them."
The former Hewlett-Packard boss - and the only woman in the Republican race - ranked second to last in the New Hampshire poll, after placing seventh in the Iowa caucuses.
Senior aides for Chris Christie are also indicating the New Jersey governor may leave the contest, after he finished sixth in New Hampshire. Governor Christie is struggling to raise the funds and build support for his campaign to seriously contest his Republican rivals. However, his spokeswoman says "no decision has been made".
In other developments on Wednesday:
In the Democratic race, Mr Sanders met civil rights activist Reverend Al Sharpton on Wednesday morning in Harlem, New York City.
But the influential clergyman said he had not yet decided whether he would back the self-described democratic socialist or Mrs Clinton.
Winning the African American vote is regarded as key for the eventual Democratic nominee as the primary race moves on in the weeks ahead.
Both parties will officially name their presidential candidates in July and Americans will finally go to the polls in November.
20 February - South Carolina primary (Republican); Nevada caucus (Democrat)
23 February - Nevada caucus (R)
27 February - South Carolina primary (D)
1 March - 'Super Tuesday' - 15 states or territories decide
18-21 July - Republican convention, nominee picked
25-28 July - Democratic convention, nominee picked
8 November - US presidential elections
In depth: Primary calendar


The chief executive of Ryanair has said that the company's remaining services at City of Derry Airport will probably move to Belfast.

Michael O'Leary said air passenger duty (APD) was to blame for a reduction of flight routes.
"I think it's inevitable overtime that the Glasgow and Liverpool services will migrate to Aldergrove," he said.
The comments were made during an announcement of 11 new routes for Belfast International.
On Monday, details were released of a Â£7m Stormont rescue deal to support the struggling Londonderry airport.
The money will be used to attract new airlines and develop its infrastructure.
The funding package has been made available immediately while negotiations are ongoing with a company interested in using the airport as a maintenance hub.
Last week it was confirmed that Ryanair was to drop a number of services from the city.
The budget airline has guaranteed its services to Glasgow and Liverpool up until Summer 2017.


Honeymooners have been touched by the generosity of a mystery well-wisher who spotted "just married" written on their car while parked at a Skye beauty spot.

Jed and Charlotte Case, from Edinburgh, were visiting the Fairy Pools in Glen Brittle earlier this week.
When they returned from their walk they found a note on their car.
Inside was a Â£10 note and the message: "Here's to a (small) round of drinks, a good time in Skye and a great life together."
A guest at the couple's wedding in Blair Atholl, Perthshire, had written "just married" on the rear bumper of their Fiat in dry-wide marker pen.
The newly-weds later headed to Skye for their honeymoon, with the Fairy Pools being among the sites on the island they visited.
Mr Case said: "We went for a walk and came back to the car where Charlotte noticed something on the windscreen.
"Amazingly, some very kind fairies had noticed our 'just married' sign and left the hand written note with money inside, underneath our windscreen wiper.
"I was blown away to be honest, at first I thought it was a parking ticket.
"I looked around the car park but couldn't see anyone to thank.
"We got back in the car and went for drink in the Old Inn in Carbost."
He added: "It was incredibly kind and it is a moment that we will never forget.
"We'll always be able to tell the honeymoon story of the fairies who gave us the most unforgettable wedding present.
"If the fairies see this, thank you so much."


They say that Christmas is the time for charity but there are going to be a few football managers across the country wishing their players had not been quite so generous this year.

BBC Sport takes a look at five things you might have missed in the EFL on the last full match day before the festive season.
There were six late winning goals in the Championship on Saturday, all with ramifications in the race for promotion and the bid to avoid relegation.
Brighton's Glenn Murray headed home in the fifth minute of stoppage time against Birmingham City to ensure the Seagulls will spend Christmas eight points clear of third-placed Reading.
Jaap Stam's men had looked like having to settle for a point at Blackburn before George Evans hit an injury-time winner to move them back up to third.
Yorkshire rivals Leeds and Sheffield Wednesday ensured they would spend Christmas in the top six thanks to winners in the 89th minute and stoppage time against Brentford and Rotherham respectively.
Meanwhile, 23rd-placed Wigan were set to take a point from their home game against Ipswich before David McGoldrick popped up with an 88th-minute winner for Mick McCarthy's men.
Match of the day in the second tier must go to Barnsley's 4-3 win at Cardiff. The Bluebirds led in the third minute before trailing 3-1 at half-time.
Peter Whittingham and Antony Pilkington's 89th-minute strike seemed to have given Neil Warnock's side an unlikely point but Ryan Williams scored in the fifth minute of injury time to make it a happy journey back to South Yorkshire for the Tykes.
Well, maybe not quite miracles but it's probably fair to say neither Wes Brown nor Isaiah Osbourne would have been fancied by many to get on the scoresheet today.
Former Manchester United and Sunderland man Brown, 37, scored on his Blackburn Rovers debut to level the match against the Royals.
It counted for nothing in the end thanks to Reading's late winner but it was Brown's first goal since netting for Sunderland in December 2011.
Walsall midfielder Osbourne only had to wait a shade over three years to end his scoring drought.
The ex-Aston Villa player opened his account for the Saddlers to give them a point against Bradford City.
He'll probably be pleased this goal meant a little more than his last one which opened the scoring for Blackpool against Derby in December 2013. The Rams went on to win 5-1.
Yeovil boss Darren Way, assistant Terry Skiverton and the 18-strong match-day squad put £300 behind the bar at Carlisle as a 'thank you' to fans for making the long trek north.
"Special mention must go to the supporters because how far they've travelled to watch this game is unbelievable commitment," Way told BBC Somerset.
"This is beyond the end of the Earth. I just hope they feel that the players gave everything and they can be proud of their team."
Travelling Glovers fans certainly seemed appreciative as they tweeted the club with pictures of pies and pints.
Sadly for the 96 Yeovil fans who made the 660-mile round trip to Brunton Park, the hosts were not in such a generous mood, with the Cumbrians claiming a 2-1 win.
Roll the clock back to 27 September and Bury are celebrating their sixth league win of the season and sit second in League One.
The following 16 games have brought a sum total of zero victories and the Shakers have slumped into the relegation zone.
David Flitcroft was sacked after presiding over seven consecutive league defeats but replacement Chris Brass, given the job until the end of the season on Thursday, has fared little better, losing his first five matches.
Bury twice took the lead at home to Oxford on Saturday but were pegged back on each occasion by a Chris Maguire free-kick before a Greg Leigh own goal gave the U's victory.
"We've got to dig in and fight a little bit harder than we are right now to keep the ball out of the net," Brass told BBC Radio Manchester.
It's been a tough start to the season for Exeter City and their match-going regulars.
Going into today's game against Mansfield, the Grecians had claimed a healthy seven wins away from home but were the only team in the EFL yet to taste success on their own turf.
Paul Tisdale's side ended their wait for a win at St James Park, which dated back to April, with a 2-0 win over the Stags thanks to a double from Ollie Watkins.
"I'm delighted," Tisdale told BBC Radio Devon. "It had to come at some point and we did it today. It was hard work and the boys have deserved it against a really strong team.
"They put us under pressure in the second half and in many respects outplayed us but we stuck to it and 2-0 is a great feeling."
Take part in our new Premier League Predictor game, which allows you to create leagues with friends.


A lack of homes for sale means that the housing market will get off to a slow start in 2017, according to surveyors.

Property transactions have slowed since the spring, the Royal Institution of Chartered Surveyors (Rics) said.
Although they may pick-up in the new year, any increase would be "modest", it added.
The survey comes the day after mortgage lender, the Halifax, said house price growth may slow in the coming months.
The Halifax did say that property price rises had accelerated in November, a picture mirrored by Rics which said a net balance of 30% of surveyors reported house prices rising rather than falling in November. This was the strongest figure seen since April.
Enquiries from potential new buyers also recorded an increase in the Rics survey.
Yet, relatively few homes being put on the market, and many being bought quickly has meant little to choose from for these buyers.
The Rics report said this highlighted the fact that "the supply shortage [is] a very dominant feature of the market at present".
Changes to the structure of stamp duty has hit the market for Â£1m-plus homes, particularly in London. A stamp duty surcharge for buy-to-let investors, which was introduced in April, has also affected the market as, said Rics, had uncertainty in the wider economy.
"This is significant not just for the housing market itself but also for the wider economy given how much of consumer spending is tied in with home purchases," said Simon Rubinsohn, chief economist at Rics.
Where can I afford to live?


Two Scottish women who attended the rock concert attacked by gunmen in Paris have been describing how they escaped.

Christine Tudhope, 34, and Mariesha Payne, 33, hid in a cellar at the Bataclan concert hall for three hours.
The majority of victims in Friday's attacks were at the concert.
The women ran for cover when they first saw bullets hit the stage during a performance by US band Eagles of Death Metal.
As they arrived at Edinburgh Airport on Sunday Ms Payne, who is from Perth, said: "A second round went off, most people ducked, but I just said run, just get out of here.
"In the confusion if we had gone left we would have instantly been out on to the street and probably the first people out of the building, but just confused we ran right and ended up being in room that we couldn't get out of.
"There were no exits but we found a door to the cellar, which we just ran into but then realised we were trapped and there was no way out of there.
"A few seconds later the door burst open and we just thought, they're coming, we are going to die.
"It was two other concert goers, we managed to barricade ourselves in, turn the lights out and we were then trapped there for the next three hours just having to listen to what was happening."
At least 129 people died in the attacks. Follow the latest updates here.
Prayers have been said for the people of Paris at religious events across Scotland on Sunday.
The Church of Scotland held a memorial service at St Giles' Cathedral in Edinburgh to honour the victims of Friday's attacks.
About 600 people gathered for the service, which included a minute's silence for those caught in the violence.
Prayers were also said at the Scots Kirk in central Paris, a traditional gathering point for Scots in the city.
The largest organisation representing Muslims in Scotland said they are "shocked at the senseless acts of wanton violence seen in Paris".
Muslim Council of Scotland convener Dr Javed Gill said "We condemn in the strongest terms this senseless violence and offer our deepest condolences to the victims.
"The targeting of innocent people going about their normal lives is nothing short of despicable."
The council said it recognised the threat posed by those behind the Paris attacks and will continue to work with the authorities in Scotland to ensure the safety of all communities.
On Saturday evening, the Usher Hall in Edinburgh and Glasgow's Hydro were lit in French colours as a mark of respect.
They were among the Scottish venues joining hundreds of landmarks around the world in their response to the Paris attacks.
A number of public events were organised in Scotland after the assaults in the French capital.
A vigil was held in Glasgow to show support for the people affected by the violence.
People gathered at the Buchanan Gallery steps to express their solidarity.
At the French Consulate in Edinburgh, people were invited to sign a book of condolence. Many floral tributes were laid outside the building.


Two sisters from north London who went missing earlier this month have been found safe and well hours after their friend was returned home.

Fardowsa Hassan, 13, was found by police in the early hours of Friday.
Her friends Abir Salah, 16, and Ahlam Salah, 15, have now also been traced by officers.
The Salah sisters were found at a separate address in Haringey to the one where Fardowsa was discovered.
More on this story and other news from London
Fardowsa's mother had said she thought her daughter could have been kidnapped and taken abroad. Speculative comparisons were made with four London schoolgirls who travelled to Syria earlier this year.
But Scotland Yard advised that none of the girls were believed to have left the London area.


Hearts winger Jamie Walker will serve a two-match ban after being found guilty of diving to win a penalty against Celtic last weekend.

The 23-year-old attended a disciplinary hearing at Hampden to contest the Scottish FA charge of simulation.
Hearts say they are "deeply disappointed" with the verdict from the SFA's judiciary panel.
Walker was branded "a cheat" by Celtic captain Scott Brown following the incident at Tynecastle.
Despite Walker converting the first half penalty, Celtic went on to win the match 2-1.
He will be suspended for league matches against Aberdeen and Inverness Caledonian Thistle.


Nigeria's President Muhammadu Buhari has blamed an "overzealous" staff member for plagiarising parts of a speech by Barack Obama.

Several passages of a speech Mr Buhari made on 8 September overlapped with President Obama's address after winning election in 2008.
His office admitted the sentences were "too close to be passed as coincidence".
The two men are due to meet at the UN General Assembly next week.
"There was a mistake by an overzealous staff and we regret that this has happened," Mr Buhari's spokesman Garba Shehu wrote on Twitter, saying those responsible would be punished.
"President Buhari urges Nigerians to look beyond this incident and focus on the message of change which the country needs in order to restore our cherished value systems."
Buhari: "We must resist the temptation to fall back on the same partisanship, pettiness and immaturity that have poisoned our country for so long."
Obama: "Let us resist the temptation to fall back on the same partisanship and pettiness and immaturity that has poisoned our politics for so long.''
Mr Buhari used the copied extracts in launching a campaign called "Change Begins With Me", part of a bid to tackle corruption in Nigeria.
The irony was not lost to some online, who mocked Mr Buhari.
On the BBC Africa Facebook page though, others were more sympathetic.
"So what's the big deal? Famous lines from great people are used over and over again by others," wrote one commentator.
"The message conveyed is the most important thing."
Earlier this year Melania Trump, the wife of Republican presidential candidate Donald Trump, was accused of plagiarising portions of Michelle Obama's 2008 Democratic National Convention speech.


Fatbergs - the collections of fat that clog up our sewers - have gone from yuck to useful.

28 June 2017 Last updated at 16:24 BST
They are caused when people pour cooking oil down the drains and can create big problems, costing water companies a lot of money to clear away.
But now, a fuel company has come up with a way to clean up fatbergs AND make them useful.
Jenny's been finding out more.