DDInter1768 DDInter1840
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Terbinafine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) upregulates {v} (Gene) ADAM12
ADAM12 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) upregulates {v} (Gene) PTPN6
PTPN6 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) downregulates {v} (Gene) WBP11
WBP11 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) upregulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) upregulates {v} (Gene) GLI2
GLI2 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Terbinafine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Terbinafine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Trabectedin (Compound)
Terbinafine (Compound) upregulates ADAM12 (Gene) and ADAM12 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Terbinafine (Compound) upregulates PTPN6 (Gene) and PTPN6 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Terbinafine (Compound) downregulates CAST (Gene) and CAST (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Terbinafine (Compound) downregulates WBP11 (Gene) and WBP11 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Terbinafine may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen (Compound) upregulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Terbinafine (Compound) upregulates GLI2 (Gene) and GLI2 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Terbinafine may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Trabectedin (Compound)
Terbinafine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)