DDInter181 DDInter1180
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine. Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Benzatropine {u} (Compound) resembles {v} (Compound) Atomoxetine
Benzatropine {u} (Compound) resembles {v} (Compound) Benzphetamine
Benzatropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Benzatropine {u} (Compound) binds {v} (Gene) SLC6A3
Benzatropine {u} (Compound) upregulates {v} (Gene) PROS1
Benzatropine {u} (Compound) palliates {v} (Disease) schizophrenia
Benzatropine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine Receptor Antagonists
Benzatropine {u} (Compound) downregulates {v} (Gene) CDC20
Benzatropine {u} (Compound) causes {v} (Side Effect) Dysuria
Benzatropine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Benzatropine (Compound) resembles Atomoxetine (Compound)
Benzatropine (Compound) resembles Benzphetamine (Compound)
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Benzatropine (Compound) binds SLC6A3 (Gene)
Benzatropine (Compound) upregulates PROS1 (Gene)
Benzatropine (Compound) palliates schizophrenia (Disease)
Benzatropine (Compound) is included by Histamine Receptor Antagonists (Pharmacologic Class)
Benzatropine (Compound) downregulates CDC20 (Gene)
Benzatropine (Compound) causes Dysuria (Side Effect)
Benzatropine may lead to a major life threatening interaction when taken with Potassium chloride