DDInter745 DDInter178
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Fludarabine {u} (Compound) resembles {v} (Compound) Adenosine triphosphate
Fludarabine {u} (Compound) treats {v} (Disease) hematologic cancer
Fludarabine {u} (Compound) binds {v} (Gene) POLA1
Fludarabine {u} (Compound) causes {v} (Side Effect) Discomfort
Fludarabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Fludarabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Fludarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palifermin
Fludarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lurbinectedin
Fludarabine {u} may lead to a major life threatening interaction when taken with {v} Natalizumab
Fludarabine {u} may lead to a major life threatening interaction when taken with {v} Bacillus calmette-guerin substrain tice live antigen
Fludarabine (Compound) resembles Adenosine triphosphate (Compound)
Fludarabine (Compound) treats hematologic cancer (Disease)
Fludarabine (Compound) binds POLA1 (Gene)
Fludarabine (Compound) causes Discomfort (Side Effect)
Fludarabine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Fludarabine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Palifermin
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Fludarabine may lead to a major life threatening interaction when taken with Natalizumab
Fludarabine may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen