DDInter89 DDInter815
Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams. This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.
Ampicillin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Gentamicin
Ampicillin {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Ampicillin {u} (Compound) resembles {v} (Compound) Piperacillin
Piperacillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Ampicillin {u} (Compound) resembles {v} (Compound) Mezlocillin
Mezlocillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Ampicillin {u} (Compound) resembles {v} (Compound) Ticarcillin
Ticarcillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Ampicillin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Gentamicin
Ampicillin {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Tobramycin
Tobramycin {u} (Compound) resembles {v} (Compound) Gentamicin
Ampicillin {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Anaphylactoid reaction {u} (Side Effect) is caused by {v} (Compound) Perindopril
Perindopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gentamicin
Ampicillin {u} (Compound) causes {v} (Side Effect) Thrombocytopenic purpura
Thrombocytopenic purpura {u} (Side Effect) is caused by {v} (Compound) Meclofenamic acid
Meclofenamic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Ampicillin {u} (Compound) resembles {v} (Compound) Piperacillin
Piperacillin {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Gentamicin
Ampicillin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Gentamicin (Compound)
Ampicillin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Ampicillin (Compound) resembles Piperacillin (Compound) and Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Ampicillin (Compound) resembles Mezlocillin (Compound) and Mezlocillin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Ampicillin (Compound) resembles Ticarcillin (Compound) and Ticarcillin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Ampicillin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Gentamicin (Compound)
Ampicillin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Tobramycin (Compound) and Tobramycin (Compound) resembles Gentamicin (Compound)
Ampicillin (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Perindopril (Compound) and Perindopril may cause a minor interaction that can limit clinical effects when taken with Gentamicin
Ampicillin (Compound) causes Thrombocytopenic purpura (Side Effect) and Thrombocytopenic purpura (Side Effect) is caused by Meclofenamic acid (Compound) and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Ampicillin (Compound) resembles Piperacillin (Compound) and Piperacillin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Gentamicin (Compound)