DDInter1510 DDInter1627
Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a child) makes it an integral to WHO's plan to eliminate schistosomiasis by 2030.[A263206,A263211] Despite being approved since 1980, the exact mechanism of action is yet to be elucidated.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Praziquantel {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Praziquantel {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Praziquantel {u} (Compound) resembles {v} (Compound) Palonosetron
Palonosetron {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Praziquantel {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Praziquantel {u} (Compound) resembles {v} (Compound) Palonosetron
Palonosetron {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Praziquantel {u} (Compound) downregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Praziquantel {u} (Compound) downregulates {v} (Gene) CSRP1
CSRP1 {u} (Gene) is regulated by {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Praziquantel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Cimetidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Praziquantel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Secobarbital
Secobarbital {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Praziquantel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Albendazole
Albendazole {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Praziquantel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Praziquantel (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Rufinamide (Compound)
Praziquantel (Compound) resembles Palonosetron (Compound) and Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Praziquantel (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Praziquantel (Compound) resembles Palonosetron (Compound) and Palonosetron (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Praziquantel (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Praziquantel (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is regulated by CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Praziquantel may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Rufinamide (Compound)
Praziquantel may cause a minor interaction that can limit clinical effects when taken with Albendazole and Albendazole (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Rufinamide (Compound)