DDInter458 DDInter1763
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) downregulates {v} (Gene) TFDP1
TFDP1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) SRPRB
SRPRB {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) binds {v} (Gene) PPIF
PPIF {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) covaries with {v} (Gene) YRDC
YRDC {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) interacts with {v} (Gene) SETDB1
SETDB1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Temsirolimus (Compound)
Cyclosporine (Compound) downregulates TFDP1 (Gene) and TFDP1 (Gene) is downregulated by Temsirolimus (Compound)
Cyclosporine (Compound) upregulates SRPRB (Gene) and SRPRB (Gene) is downregulated by Temsirolimus (Compound)
Cyclosporine (Compound) binds PPIF (Gene) and PPIF (Gene) is downregulated by Temsirolimus (Compound)
Cyclosporine (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Temsirolimus (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) covaries with YRDC (Gene) and YRDC (Gene) is downregulated by Temsirolimus (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) interacts with SETDB1 (Gene) and SETDB1 (Gene) is upregulated by Temsirolimus (Compound)