DDInter128 DDInter1397
Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Astemizole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Astemizole {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) regulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) upregulates {v} (Gene) FDPS
FDPS {u} (Gene) regulates {v} (Gene) TPI1
TPI1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) upregulates {v} (Gene) MSMO1
MSMO1 {u} (Gene) is regulated by {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Astemizole {u} (Compound) upregulates {v} (Gene) ALDOC
ALDOC {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Astemizole {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) interacts with {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Astemizole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Astemizole (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Astemizole (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Paroxetine (Compound)
Astemizole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Astemizole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Astemizole (Compound) upregulates LIPA (Gene) and LIPA (Gene) regulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Astemizole (Compound) upregulates FDPS (Gene) and FDPS (Gene) regulates TPI1 (Gene) and TPI1 (Gene) is downregulated by Paroxetine (Compound)
Astemizole (Compound) upregulates MSMO1 (Gene) and MSMO1 (Gene) is regulated by SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)
Astemizole (Compound) upregulates ALDOC (Gene) and ALDOC (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Astemizole (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) interacts with SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)