DDInter1042 DDInter1606
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Adrenergic beta-agonist used to control premature labor.
Ritodrine {u} (Compound) resembles {v} (Compound) Arformoterol
Ritodrine {u} (Compound) resembles {v} (Compound) Dobutamine
Ritodrine {u} (Compound) binds {v} (Gene) GALR3
Ritodrine {u} (Compound) upregulates {v} (Gene) TGFBR2
Ritodrine {u} (Compound) downregulates {v} (Gene) POLR2I
Ritodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Flunisolide
Ritodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ciclesonide
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylpropanolamine
Ritodrine {u} may lead to a major life threatening interaction when taken with {v} Ivosidenib
Ritodrine (Compound) resembles Arformoterol (Compound)
Ritodrine (Compound) resembles Dobutamine (Compound)
Ritodrine (Compound) binds GALR3 (Gene)
Ritodrine (Compound) upregulates TGFBR2 (Gene)
Ritodrine (Compound) downregulates POLR2I (Gene)
Ritodrine may cause a minor interaction that can limit clinical effects when taken with Flunisolide
Ritodrine may cause a minor interaction that can limit clinical effects when taken with Ciclesonide
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamine
Ritodrine may lead to a major life threatening interaction when taken with Ivosidenib