DDInter548 DDInter416
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers . The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot .
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Bifonazole
Bifonazole {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR1
ESR1 {u} (Gene) interacts with {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) upregulates {v} (Gene) CCP110
CCP110 {u} (Gene) is upregulated by {v} (Compound) Bifonazole
Bifonazole {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) Clofedanol
Clofedanol {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Diethylstilbestrol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Clotrimazole (Compound)
Diethylstilbestrol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Diethylstilbestrol (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Bifonazole (Compound) and Bifonazole (Compound) resembles Clotrimazole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide (Compound) resembles Clotrimazole (Compound)
Diethylstilbestrol (Compound) binds ESR1 (Gene) and ESR1 (Gene) interacts with PHGDH (Gene) and PHGDH (Gene) is upregulated by Clotrimazole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) resembles Methadone (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) resembles Clotrimazole (Compound)
Diethylstilbestrol (Compound) upregulates CCP110 (Gene) and CCP110 (Gene) is upregulated by Bifonazole (Compound) and Bifonazole (Compound) resembles Clotrimazole (Compound)
Diethylstilbestrol (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by PCK2 (Gene) and PCK2 (Gene) is upregulated by Clotrimazole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) resembles Clofedanol (Compound) and Clofedanol (Compound) resembles Clotrimazole (Compound)
Diethylstilbestrol (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Loperamide (Compound) and Loperamide (Compound) resembles Clotrimazole (Compound)