DDInter380 DDInter1397
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Cimetidine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is associated with {v} (Gene) LPIN1
LPIN1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is regulated by {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) binds {v} (Gene) SLC22A4
SLC22A4 {u} (Gene) regulates {v} (Gene) TIMELESS
TIMELESS {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Cimetidine {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is associated with {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Paroxetine
Cimetidine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Cimetidine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Paroxetine (Compound)
Cimetidine (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Cimetidine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Cimetidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Cimetidine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Cimetidine (Compound) treats obesity (Disease) and obesity (Disease) is associated with LPIN1 (Gene) and LPIN1 (Gene) is upregulated by Paroxetine (Compound)
Cimetidine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is regulated by SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)
Cimetidine (Compound) binds SLC22A4 (Gene) and SLC22A4 (Gene) regulates TIMELESS (Gene) and TIMELESS (Gene) is downregulated by Paroxetine (Compound)
Cimetidine (Compound) treats obesity (Disease) and obesity (Disease) is associated with HTR2A (Gene) and HTR2A (Gene) is bound by Paroxetine (Compound)