DDInter1928 DDInter1544
Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications. Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Verapamil {u} (Compound) resembles {v} (Compound) Bevantolol
Verapamil {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Verapamil {u} (Compound) treats {v} (Disease) migraine
Verapamil {u} (Compound) binds {v} (Gene) CACNB2
Verapamil {u} (Compound) upregulates {v} (Gene) MCOLN1
Verapamil {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Verapamil {u} (Compound) downregulates {v} (Gene) DNAJA3
Verapamil {u} (Compound) causes {v} (Side Effect) Diarrhoea
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Verapamil (Compound) resembles Bevantolol (Compound)
Verapamil (Compound) resembles Trimethobenzamide (Compound)
Verapamil (Compound) treats migraine (Disease)
Verapamil (Compound) binds CACNB2 (Gene)
Verapamil (Compound) upregulates MCOLN1 (Gene)
Verapamil (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Verapamil (Compound) downregulates DNAJA3 (Gene)
Verapamil (Compound) causes Diarrhoea (Side Effect)
Verapamil may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Verapamil may cause a minor interaction that can limit clinical effects when taken with Bexarotene