DDInter150 DDInter484
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein BCR-ABL. BCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the pathogenesis of CML and 15-30% of ALL cases.[A11377,A33432] Dasatinib also inhibits a spectrum of kinases involved in cancer, including several SRC-family kinases. Unlike [imatinib], another tyrosine kinase used for the treatment of CML and Ph-positive ALL, dasatinib inhibits the active and inactive conformations of the ABL kinase domain.[A2226,A11377] Also, mutations in the kinase domain of BCR-ABL may lead to relapse during imatinib treatment. Since dasatinib does not interact with some of the residues involved in those mutations, the use of this drug represents a therapeutic alternative for patients with cancers that have developed imatinib-resistance. The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186]
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) downregulates {v} (Gene) INTS3
INTS3 {u} (Gene) is upregulated by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) ABL1
ABL1 {u} (Gene) is bound by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is downregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) downregulates {v} (Gene) INTS3
INTS3 {u} (Gene) is regulated by {v} (Gene) BMPR1B
BMPR1B {u} (Gene) is bound by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) regulates {v} (Gene) EML3
EML3 {u} (Gene) is upregulated by {v} (Compound) Dasatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Dasatinib
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Dasatinib (Compound)
Azathioprine (Compound) downregulates INTS3 (Gene) and INTS3 (Gene) is upregulated by Dasatinib (Compound)
Azathioprine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Dasatinib (Compound)
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Dasatinib (Compound)
Azathioprine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by ABL1 (Gene) and ABL1 (Gene) is bound by Dasatinib (Compound)
Azathioprine (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is downregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dasatinib (Compound)
Azathioprine (Compound) downregulates INTS3 (Gene) and INTS3 (Gene) is regulated by BMPR1B (Gene) and BMPR1B (Gene) is bound by Dasatinib (Compound)
Azathioprine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) regulates EML3 (Gene) and EML3 (Gene) is upregulated by Dasatinib (Compound)
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dasatinib (Compound)