DDInter76 DDInter1016
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Amiodarone {u} (Compound) resembles {v} (Compound) Dronedarone
Amiodarone {u} (Compound) resembles {v} (Compound) Lucanthone
Amiodarone {u} (Compound) binds {v} (Gene) CACNA2D2
Amiodarone {u} (Compound) upregulates {v} (Gene) HMGCS1
Amiodarone {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 2C9 Inhibitors
Amiodarone {u} (Compound) downregulates {v} (Gene) PRPF4
Amiodarone {u} (Compound) causes {v} (Side Effect) Dermatitis exfoliative
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Amiodarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Liothyronine
Amiodarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nintedanib
Amiodarone (Compound) resembles Dronedarone (Compound)
Amiodarone (Compound) resembles Lucanthone (Compound)
Amiodarone (Compound) binds CACNA2D2 (Gene)
Amiodarone (Compound) upregulates HMGCS1 (Gene)
Amiodarone (Compound) is included by Cytochrome P450 2C9 Inhibitors (Pharmacologic Class)
Amiodarone (Compound) downregulates PRPF4 (Gene)
Amiodarone (Compound) causes Dermatitis exfoliative (Side Effect)
Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib