DDInter535 DDInter513
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Diazoxide {u} (Compound) upregulates {v} (Gene) CASP2
CASP2 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Diazoxide {u} (Compound) upregulates {v} (Gene) CASP2
CASP2 {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) is upregulated by {v} (Compound) Budesonide
Budesonide {u} (Compound) resembles {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is upregulated by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Diazoxide {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Diazoxide (Compound) upregulates CASP2 (Gene) and CASP2 (Gene) is upregulated by Dexamethasone (Compound)
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) is upregulated by Dexamethasone (Compound)
Diazoxide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is upregulated by Dexamethasone (Compound)
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dexamethasone (Compound)
Diazoxide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dexamethasone (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone
Diazoxide (Compound) upregulates CASP2 (Gene) and CASP2 (Gene) is upregulated by Betamethasone (Compound) and Betamethasone (Compound) resembles Dexamethasone (Compound)
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) is upregulated by Budesonide (Compound) and Budesonide (Compound) resembles Dexamethasone (Compound)
Diazoxide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is upregulated by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Diazoxide (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)