DDInter1213 DDInter1376
An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Midodrine {u} (Compound) resembles {v} (Compound) Agomelatine
Midodrine {u} (Compound) resembles {v} (Compound) Methoxamine
Midodrine {u} (Compound) binds {v} (Gene) CYP2D6
Midodrine {u} (Compound) upregulates {v} (Gene) FKBP14
Midodrine {u} (Compound) downregulates {v} (Gene) TUBB6
Midodrine {u} (Compound) causes {v} (Side Effect) Agitation
Midodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Midodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orciprenaline
Midodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentermine
Midodrine {u} may lead to a major life threatening interaction when taken with {v} Iobenguane
Midodrine (Compound) resembles Agomelatine (Compound)
Midodrine (Compound) resembles Methoxamine (Compound)
Midodrine (Compound) binds CYP2D6 (Gene)
Midodrine (Compound) upregulates FKBP14 (Gene)
Midodrine (Compound) downregulates TUBB6 (Gene)
Midodrine (Compound) causes Agitation (Side Effect)
Midodrine may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine
Midodrine may lead to a major life threatening interaction when taken with Iobenguane