DDInter336 DDInter1796
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618). Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Thioridazine
Celecoxib {u} (Compound) upregulates {v} (Gene) ST3GAL5
ST3GAL5 {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Thioridazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Cholestasis
Cholestasis {u} (Side Effect) is caused by {v} (Compound) Thioridazine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Thioridazine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Thioridazine
Celecoxib {u} (Compound) upregulates {v} (Gene) ST3GAL5
ST3GAL5 {u} (Gene) is upregulated by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Thioridazine
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) regulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Cholestasis
Cholestasis {u} (Side Effect) is caused by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Thioridazine
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Thioridazine
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Thioridazine (Compound)
Celecoxib (Compound) upregulates ST3GAL5 (Gene) and ST3GAL5 (Gene) is upregulated by Thioridazine (Compound)
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Thioridazine (Compound)
Celecoxib (Compound) causes Cholestasis (Side Effect) and Cholestasis (Side Effect) is caused by Thioridazine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Thioridazine (Compound)
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Perphenazine (Compound) and Perphenazine (Compound) resembles Thioridazine (Compound)
Celecoxib (Compound) upregulates ST3GAL5 (Gene) and ST3GAL5 (Gene) is upregulated by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Thioridazine (Compound)
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) regulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Thioridazine (Compound)
Celecoxib (Compound) causes Cholestasis (Side Effect) and Cholestasis (Side Effect) is caused by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Thioridazine (Compound)
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Thioridazine (Compound)