DDInter1340 DDInter554
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digitalis_ plant, studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.
Omeprazole {u} (Compound) binds {v} (Gene) CYP11A1
CYP11A1 {u} (Gene) is bound by {v} (Compound) Digoxin
Omeprazole {u} (Compound) upregulates {v} (Gene) TIPARP
TIPARP {u} (Gene) is upregulated by {v} (Compound) Digoxin
Omeprazole {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Digoxin
Omeprazole {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Digoxin
Omeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin
Omeprazole {u} (Compound) resembles {v} (Compound) Lansoprazole
Lansoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin
Omeprazole {u} (Compound) binds {v} (Gene) CYP11A1
CYP11A1 {u} (Gene) is bound by {v} (Compound) Digitoxin
Digitoxin {u} (Compound) resembles {v} (Compound) Digoxin
Omeprazole {u} (Compound) upregulates {v} (Gene) TIPARP
TIPARP {u} (Gene) is upregulated by {v} (Compound) Ouabain
Ouabain {u} (Compound) resembles {v} (Compound) Digoxin
Omeprazole {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Ouabain
Ouabain {u} (Compound) resembles {v} (Compound) Digoxin
Omeprazole {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Gentamicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Omeprazole (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) is bound by Digoxin (Compound)
Omeprazole (Compound) upregulates TIPARP (Gene) and TIPARP (Gene) is upregulated by Digoxin (Compound)
Omeprazole (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Digoxin (Compound)
Omeprazole (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Digoxin (Compound)
Omeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Digoxin
Omeprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Digoxin
Omeprazole (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) is bound by Digitoxin (Compound) and Digitoxin (Compound) resembles Digoxin (Compound)
Omeprazole (Compound) upregulates TIPARP (Gene) and TIPARP (Gene) is upregulated by Ouabain (Compound) and Ouabain (Compound) resembles Digoxin (Compound)
Omeprazole (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Ouabain (Compound) and Ouabain (Compound) resembles Digoxin (Compound)
Omeprazole (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Gentamicin (Compound) and Gentamicin may cause a minor interaction that can limit clinical effects when taken with Digoxin