DDInter1639 DDInter1531
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Sapropterin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Proguanil
Sapropterin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Lamotrigine
Lamotrigine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Proguanil
Sapropterin {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Quinapril
Quinapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Sapropterin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Sapropterin {u} (Compound) upregulates {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Auranofin {u} may lead to a major life threatening interaction when taken with {v} Proguanil
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Auranofin {u} may lead to a major life threatening interaction when taken with {v} Proguanil
Sapropterin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Sapropterin {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Disease) malaria
malaria {u} (Disease) is treated by {v} (Compound) Proguanil
Sapropterin {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Auranofin
Auranofin {u} may lead to a major life threatening interaction when taken with {v} Proguanil
Sapropterin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Proguanil (Compound)
Sapropterin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Lamotrigine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Proguanil
Sapropterin (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Quinapril (Compound) and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Pyrimethamine (Compound) and Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Sapropterin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Sapropterin (Compound) upregulates GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Auranofin (Compound) and Auranofin may lead to a major life threatening interaction when taken with Proguanil
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Auranofin (Compound) and Auranofin may lead to a major life threatening interaction when taken with Proguanil
Sapropterin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Pyrimethamine (Compound) and Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Sapropterin (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by malaria (Disease) and malaria (Disease) is treated by Proguanil (Compound)
Sapropterin (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Auranofin (Compound) and Auranofin may lead to a major life threatening interaction when taken with Proguanil