DDInter458 DDInter405
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLGAP5
DLGAP5 {u} (Gene) is downregulated by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) upregulates {v} (Gene) HDAC6
HDAC6 {u} (Gene) is downregulated by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Clofarabine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Clofarabine
Cyclosporine {u} (Compound) downregulates {v} (Gene) RRM2
RRM2 {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Clofarabine
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Clofarabine (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Clofarabine (Compound)
Cyclosporine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Clofarabine (Compound)
Cyclosporine (Compound) downregulates PNP (Gene) and PNP (Gene) is upregulated by Clofarabine (Compound)
Cyclosporine (Compound) downregulates DLGAP5 (Gene) and DLGAP5 (Gene) is downregulated by Clofarabine (Compound)
Cyclosporine (Compound) upregulates HDAC6 (Gene) and HDAC6 (Gene) is downregulated by Clofarabine (Compound)
Cyclosporine (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Clofarabine (Compound)
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Nelarabine (Compound) and Nelarabine (Compound) resembles Clofarabine (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Cyclosporine (Compound) downregulates RRM2 (Gene) and RRM2 (Gene) is downregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Clofarabine (Compound)