DDInter576 DDInter1662
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Disulfiram {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Disulfiram {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Disulfiram {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Disulfiram {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Sertraline
Disulfiram {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Sertraline
Disulfiram {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) regulates {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Disulfiram {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Disulfiram {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Disulfiram (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)
Disulfiram (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Sertraline (Compound)
Disulfiram (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Sertraline (Compound)
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Sertraline (Compound)
Disulfiram (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Sertraline (Compound)
Disulfiram (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by MAOB (Gene) and MAOB (Gene) is bound by Sertraline (Compound)
Disulfiram (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) regulates GNPDA1 (Gene) and GNPDA1 (Gene) is upregulated by Sertraline (Compound)
Disulfiram (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Sertraline (Compound)
Disulfiram (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is upregulated by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)