DDInter79 DDInter1652
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers. Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Amlodipine {u} (Compound) resembles {v} (Compound) Nilvadipine
Amlodipine {u} (Compound) resembles {v} (Compound) Isradipine
Amlodipine {u} (Compound) treats {v} (Disease) hypertension
Amlodipine {u} (Compound) binds {v} (Gene) CACNA1B
Amlodipine {u} (Compound) upregulates {v} (Gene) ACLY
Amlodipine {u} (Compound) palliates {v} (Disease) coronary artery disease
Amlodipine {u} (Compound) is included by {v} (Pharmacologic Class) Dihydropyridines
Amlodipine {u} (Compound) downregulates {v} (Gene) NOLC1
Amlodipine {u} (Compound) causes {v} (Side Effect) Weight increased
Amlodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Amlodipine (Compound) resembles Nilvadipine (Compound)
Amlodipine (Compound) resembles Isradipine (Compound)
Amlodipine (Compound) treats hypertension (Disease)
Amlodipine (Compound) binds CACNA1B (Gene)
Amlodipine (Compound) upregulates ACLY (Gene)
Amlodipine (Compound) palliates coronary artery disease (Disease)
Amlodipine (Compound) is included by Dihydropyridines (Pharmacologic Class)
Amlodipine (Compound) downregulates NOLC1 (Gene)
Amlodipine (Compound) causes Weight increased (Side Effect)
Amlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide