DDInter458 DDInter1906
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.[A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by 7b-epimerization of [chenodeoxycholic acid], which is a primary bile acid. Due to its hydrophilicity, UDCA is less toxic than [cholic acid] or [chenodeoxycholic acid]. UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary biliary cirrhosis in 1996. UDCA works by replacing the hydrophobic or more toxic bile acids from the bile acid pool.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Tauroursodeoxycholic acid
Tauroursodeoxycholic acid {u} (Compound) resembles {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is associated with {v} (Disease) primary biliary cirrhosis
primary biliary cirrhosis {u} (Disease) is treated by {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} (Compound) resembles {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} (Compound) resembles {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) SLC7A11
SLC7A11 {u} (Gene) is bound by {v} (Compound) Tauroursodeoxycholic acid
Tauroursodeoxycholic acid {u} (Compound) resembles {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is regulated by {v} (Gene) AKR1C2
AKR1C2 {u} (Gene) is bound by {v} (Compound) Ursodeoxycholic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Aluminum hydroxide
Aluminum hydroxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ursodeoxycholic acid
Cyclosporine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Tauroursodeoxycholic acid (Compound) and Tauroursodeoxycholic acid (Compound) resembles Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is associated with primary biliary cirrhosis (Disease) and primary biliary cirrhosis (Disease) is treated by Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid (Compound) resembles Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid (Compound) resembles Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) upregulates SLC7A11 (Gene) and SLC7A11 (Gene) is bound by Tauroursodeoxycholic acid (Compound) and Tauroursodeoxycholic acid (Compound) resembles Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is regulated by AKR1C2 (Gene) and AKR1C2 (Gene) is bound by Ursodeoxycholic acid (Compound)
Cyclosporine (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Aluminum hydroxide (Compound) and Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Ursodeoxycholic acid