DDInter1666 DDInter1376
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Sildenafil {u} (Compound) binds {v} (Gene) PDE6C
Sildenafil {u} (Compound) upregulates {v} (Gene) LPL
Sildenafil {u} (Compound) palliates {v} (Disease) type 1 diabetes mellitus
Sildenafil {u} (Compound) downregulates {v} (Gene) IGFBP2
Sildenafil {u} (Compound) causes {v} (Side Effect) Loss of consciousness
Sildenafil (Compound) resembles Vardenafil (Compound)
Sildenafil (Compound) binds PDE6C (Gene)
Sildenafil (Compound) upregulates LPL (Gene)
Sildenafil (Compound) palliates type 1 diabetes mellitus (Disease)
Sildenafil (Compound) downregulates IGFBP2 (Gene)
Sildenafil (Compound) causes Loss of consciousness (Side Effect)