DDInter1013 DDInter1376
Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Labetalol {u} may lead to a major life threatening interaction when taken with {v} Salmeterol
Labetalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Labetalol {u} (Compound) resembles {v} (Compound) Benazepril
Labetalol {u} (Compound) treats {v} (Disease) hypertension
Labetalol {u} (Compound) binds {v} (Gene) CYP2D6
Labetalol {u} (Compound) causes {v} (Side Effect) Lupus erythematosus
Labetalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Liothyronine
Labetalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magaldrate
Labetalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Labetalol (Compound) resembles Fenoprofen (Compound)
Labetalol may lead to a major life threatening interaction when taken with Salmeterol
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Labetalol (Compound) resembles Benazepril (Compound)
Labetalol (Compound) treats hypertension (Disease)
Labetalol (Compound) binds CYP2D6 (Gene)
Labetalol (Compound) causes Lupus erythematosus (Side Effect)
Labetalol may cause a minor interaction that can limit clinical effects when taken with Liothyronine
Labetalol may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine