DDInter456 DDInter255
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Cyclophosphamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) interacts with {v} (Gene) TEX10
TEX10 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) DUSP11
DUSP11 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) CHMP4A
CHMP4A {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is regulated by {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is upregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) CDK4
CDK4 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Cyclophosphamide {u} (Compound) resembles {v} (Compound) Mechlorethamine
Mechlorethamine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Cyclophosphamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Busulfan (Compound)
Cyclophosphamide (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) interacts with TEX10 (Gene) and TEX10 (Gene) is upregulated by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates DUSP11 (Gene) and DUSP11 (Gene) is upregulated by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates CHMP4A (Gene) and CHMP4A (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is regulated by PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is upregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Cyclophosphamide (Compound) downregulates CDK4 (Gene) and CDK4 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Cyclophosphamide (Compound) resembles Mechlorethamine (Compound) and Mechlorethamine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)