DDInter1072 DDInter1397
An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment. Lindane is still allowed for pharmaceutical use until 2015.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Lindane {u} (Compound) causes {v} (Side Effect) Dermatitis contact
Dermatitis contact {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Lindane {u} (Compound) binds {v} (Gene) GABRB1
GABRB1 {u} (Gene) interacts with {v} (Gene) C1QBP
C1QBP {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benzphetamine
Benzphetamine {u} (Compound) binds {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meropenem
Meropenem {u} (Compound) causes {v} (Side Effect) Colitis
Colitis {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Morphine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nalbuphine
Nalbuphine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nalbuphine
Nalbuphine {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Morphine {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Anaphylactoid reaction {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpromazine
Chlorpromazine {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Lindane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentazocine
Pentazocine {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Lindane (Compound) causes Dermatitis contact (Side Effect) and Dermatitis contact (Side Effect) is caused by Paroxetine (Compound)
Lindane (Compound) binds GABRB1 (Gene) and GABRB1 (Gene) interacts with C1QBP (Gene) and C1QBP (Gene) is downregulated by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Meropenem and Meropenem (Compound) causes Colitis (Side Effect) and Colitis (Side Effect) is caused by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) binds EBP (Gene) and EBP (Gene) is upregulated by Paroxetine (Compound)