DDInter1237 DDInter856
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Moexipril {u} (Compound) resembles {v} (Compound) Ramipril
Moexipril {u} (Compound) resembles {v} (Compound) Donepezil
Moexipril {u} (Compound) treats {v} (Disease) hypertension
Moexipril {u} (Compound) binds {v} (Gene) SLC15A2
Moexipril {u} (Compound) downregulates {v} (Gene) RNF167
Moexipril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Moexipril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Erythropoietin
Moexipril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Moexipril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Moexipril {u} may lead to a major life threatening interaction when taken with {v} Potassium gluconate
Moexipril (Compound) resembles Ramipril (Compound)
Moexipril (Compound) resembles Donepezil (Compound)
Moexipril (Compound) treats hypertension (Disease)
Moexipril (Compound) binds SLC15A2 (Gene)
Moexipril (Compound) downregulates RNF167 (Gene)
Moexipril may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Moexipril may cause a minor interaction that can limit clinical effects when taken with Erythropoietin
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Moexipril may lead to a major life threatening interaction when taken with Potassium gluconate