DDInter405 DDInter298
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Clofarabine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Carboplatin
Clofarabine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Clofarabine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cisplatin
Cisplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Clofarabine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is associated with {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cisplatin
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Clofarabine {u} (Compound) upregulates {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) is downregulated by {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Clofarabine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Melphalan {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Clofarabine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) SOD1
SOD1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Carboplatin (Compound)
Clofarabine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Carboplatin (Compound)
Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Carboplatin (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Clofarabine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is associated with esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Carboplatin (Compound)
Clofarabine (Compound) upregulates TNFAIP3 (Gene) and TNFAIP3 (Gene) is downregulated by ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Carboplatin (Compound)
Clofarabine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is downregulated by breast cancer (Disease) and CXCL2 (Disease) associated with breast cancer (Gene) and breast cancer (Disease) is treated by Carboplatin (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Carboplatin (Compound)
Clofarabine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is regulated by SOD1 (Gene) and SOD1 (Gene) is bound by Carboplatin (Compound)