DDInter1938 DDInter1335
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Vincristine {u} (Compound) upregulates {v} (Gene) DUSP8
DUSP8 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) downregulates {v} (Gene) ATF6
ATF6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) downregulates {v} (Gene) B4GAT1
B4GAT1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) binds {v} (Gene) TUBB
TUBB {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Vincristine {u} (Compound) upregulates {v} (Gene) DUSP8
DUSP8 {u} (Gene) is regulated by {v} (Gene) GRN
GRN {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) downregulates {v} (Gene) ATF6
ATF6 {u} (Gene) is regulated by {v} (Gene) TXNL4B
TXNL4B {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) regulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Vincristine (Compound) upregulates DUSP8 (Gene) and DUSP8 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) downregulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) binds TUBB (Gene) and TUBB (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) binds TUBB6 (Gene) and Vincristine (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Vincristine (Compound) upregulates DUSP8 (Gene) and DUSP8 (Gene) is regulated by GRN (Gene) and GRN (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) downregulates ATF6 (Gene) and ATF6 (Gene) is regulated by TXNL4B (Gene) and TXNL4B (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Vincristine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) regulates CHIC2 (Gene) and CHIC2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)