DDInter458 DDInter596
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) CBR1
CBR1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) SLC25A4
SLC25A4 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNA2
CCNA2 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urine abnormality
Urine abnormality {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxorubicin (Compound)
Cyclosporine (Compound) downregulates CBR1 (Gene) and CBR1 (Gene) is bound by Doxorubicin (Compound)
Cyclosporine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Doxorubicin (Compound)
Cyclosporine (Compound) downregulates SLC25A4 (Gene) and SLC25A4 (Gene) is upregulated by Doxorubicin (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Doxorubicin (Compound)
Cyclosporine (Compound) downregulates CCNA2 (Gene) and CCNA2 (Gene) is downregulated by Doxorubicin (Compound)
Cyclosporine (Compound) causes Urine abnormality (Side Effect) and Urine abnormality (Side Effect) is caused by Doxorubicin (Compound)
Cyclosporine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Doxorubicin (Compound) and TOP2A (Gene) is downregulated by Doxorubicin (Compound)
Cyclosporine (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is bound by Doxorubicin (Compound) and ABCC10 (Gene) is upregulated by Doxorubicin (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)