DDInter255 DDInter1627
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Busulfan {u} (Compound) downregulates {v} (Gene) STXBP1
STXBP1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Busulfan {u} (Compound) downregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is regulated by {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) upregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) interacts with {v} (Gene) SCN1A
SCN1A {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is regulated by {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) upregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) downregulates {v} (Gene) PRKCD
PRKCD {u} (Gene) interacts with {v} (Gene) GRM5
GRM5 {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Busulfan (Compound) downregulates STXBP1 (Gene) and STXBP1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Busulfan (Compound) downregulates TXNRD1 (Gene) and TXNRD1 (Gene) is regulated by CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) upregulates PSMD2 (Gene) and PSMD2 (Gene) interacts with SCN1A (Gene) and SCN1A (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) upregulates C5 (Gene) and C5 (Gene) is regulated by CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) upregulates PSMD2 (Gene) and PSMD2 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) downregulates PRKCD (Gene) and PRKCD (Gene) interacts with GRM5 (Gene) and GRM5 (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)