DDInter1451 DDInter856
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter&#39;s syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Phenylbutazone {u} (Compound) resembles {v} (Compound) Alverine
Phenylbutazone {u} (Compound) resembles {v} (Compound) Methadone
Phenylbutazone {u} (Compound) binds {v} (Gene) PTGIS
Phenylbutazone {u} (Compound) upregulates {v} (Gene) GPATCH8
Phenylbutazone {u} (Compound) downregulates {v} (Gene) TNIP1
Phenylbutazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Phenylbutazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Phenylbutazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Phenylbutazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Phenylbutazone {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Phenylbutazone (Compound) resembles Alverine (Compound)
Phenylbutazone (Compound) resembles Methadone (Compound)
Phenylbutazone (Compound) binds PTGIS (Gene)
Phenylbutazone (Compound) upregulates GPATCH8 (Gene)
Phenylbutazone (Compound) downregulates TNIP1 (Gene)
Phenylbutazone may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Phenylbutazone may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Phenylbutazone may lead to a major life threatening interaction when taken with Iohexol