DDInter1254 DDInter957
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Nabumetone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Nabumetone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Nabumetone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Repaglinide {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Nabumetone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Repaglinide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Methotrexate
Methotrexate {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Methotrexate
Methotrexate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Naproxen {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Nabumetone {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Naproxen {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Iohexol {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iodipamide
Nabumetone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Nabumetone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Diatrizoate (Compound) and Diatrizoate (Compound) resembles Iodipamide (Compound)
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)
Nabumetone may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Nabumetone may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Nabumetone (Compound) resembles Naproxen (Compound) and Naproxen (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Nabumetone (Compound) palliates rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Nabumetone (Compound) resembles Naproxen (Compound) and Naproxen (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Nabumetone may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iodipamide (Compound)