DDInter416 DDInter604
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as drospirenone exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be considered when assessing potential risks of hormonal contraceptive use.
Clotrimazole {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Drospirenone
Clotrimazole {u} (Compound) binds {v} (Gene) CYP17A1
CYP17A1 {u} (Gene) is associated with {v} (Disease) polycystic ovary syndrome
polycystic ovary syndrome {u} (Disease) is palliated by {v} (Compound) Drospirenone
Clotrimazole (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Drospirenone (Compound)
Clotrimazole (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Testosterone (Compound) and Testosterone (Compound) resembles Drospirenone (Compound)
Clotrimazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Drospirenone (Compound)
Clotrimazole (Compound) binds CYP17A1 (Gene) and CYP17A1 (Gene) is associated with polycystic ovary syndrome (Disease) and polycystic ovary syndrome (Disease) is palliated by Drospirenone (Compound)