DDInter624 DDInter405
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Efavirenz {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Clofarabine
Efavirenz {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Clofarabine
Efavirenz {u} (Compound) causes {v} (Side Effect) Skin hyperpigmentation
Skin hyperpigmentation {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clofarabine
Efavirenz {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Ribavirin
Ribavirin {u} (Compound) resembles {v} (Compound) Clofarabine
Efavirenz {u} (Compound) causes {v} (Side Effect) Rash generalised
Rash generalised {u} (Side Effect) is caused by {v} (Compound) Maraviroc
Maraviroc {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Efavirenz {u} (Compound) causes {v} (Side Effect) Renal failure acute
Renal failure acute {u} (Side Effect) is caused by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Clofarabine
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) ZNF274
ZNF274 {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethotoin
Ethotoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) upregulates {v} (Gene) RRM2
RRM2 {u} (Gene) is bound by {v} (Compound) Clofarabine
Efavirenz {u} (Compound) causes {v} (Side Effect) Necrosis
Necrosis {u} (Side Effect) is caused by {v} (Compound) Nevirapine
Nevirapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Efavirenz (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Clofarabine (Compound)
Efavirenz (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Nelarabine (Compound) and Nelarabine (Compound) resembles Clofarabine (Compound)
Efavirenz (Compound) causes Skin hyperpigmentation (Side Effect) and Skin hyperpigmentation (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Clofarabine
Efavirenz (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Ribavirin (Compound) and Ribavirin (Compound) resembles Clofarabine (Compound)
Efavirenz (Compound) causes Rash generalised (Side Effect) and Rash generalised (Side Effect) is caused by Maraviroc (Compound) and Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
Efavirenz (Compound) causes Renal failure acute (Side Effect) and Renal failure acute (Side Effect) is caused by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates ZNF274 (Gene) and ZNF274 (Gene) is upregulated by Clofarabine (Compound)
Efavirenz (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethotoin (Compound) and Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) upregulates RRM2 (Gene) and RRM2 (Gene) is bound by Clofarabine (Compound)
Efavirenz (Compound) causes Necrosis (Side Effect) and Necrosis (Side Effect) is caused by Nevirapine (Compound) and Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine