DDInter1397 DDInter149
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Paroxetine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Ketotifen
Ketotifen {u} (Compound) resembles {v} (Compound) Azatadine
Paroxetine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Ketotifen
Ketotifen {u} (Compound) resembles {v} (Compound) Azatadine
Paroxetine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Ipratropium
Ipratropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Paroxetine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Paroxetine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Azatadine
Paroxetine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Molindone
Molindone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Paroxetine {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Alfentanil
Alfentanil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Paroxetine {u} (Compound) causes {v} (Side Effect) Sleep disturbance
Sleep disturbance {u} (Side Effect) is caused by {v} (Compound) Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Pirenzepine
Pirenzepine {u} (Compound) resembles {v} (Compound) Azatadine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Paroxetine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Ketotifen (Compound) and Ketotifen (Compound) resembles Azatadine (Compound)
Paroxetine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ketotifen (Compound) and Ketotifen (Compound) resembles Azatadine (Compound)
Paroxetine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Ipratropium (Compound) and Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Paroxetine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Paroxetine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Azatadine (Compound)
Paroxetine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Molindone (Compound) and Molindone may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Paroxetine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Alfentanil (Compound) and Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Paroxetine (Compound) causes Sleep disturbance (Side Effect) and Sleep disturbance (Side Effect) is caused by Amitriptyline (Compound) and Amitriptyline (Compound) resembles Azatadine (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Paroxetine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Pirenzepine (Compound) and Pirenzepine (Compound) resembles Azatadine (Compound)
Paroxetine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine