DDInter1834 DDInter543
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. Dicyclomine was granted FDA approval on 11 May 1950.
Topiramate {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Dicyclomine
Topiramate {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Digoxin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dicyclomine
Topiramate {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dicyclomine
Topiramate {u} (Compound) causes {v} (Side Effect) Accommodation disorder
Accommodation disorder {u} (Side Effect) is caused by {v} (Compound) Protriptyline
Protriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dicyclomine
Topiramate {u} (Compound) causes {v} (Side Effect) Hallucination, visual
Hallucination, visual {u} (Side Effect) is caused by {v} (Compound) Pilocarpine
Pilocarpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dicyclomine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) CHRM3
CHRM3 {u} (Gene) is bound by {v} (Compound) Dicyclomine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Dicyclomine
Topiramate {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dicyclomine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Digoxin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dicyclomine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Zonisamide
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Dicyclomine
Topiramate (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Dicyclomine (Compound)
Topiramate (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Digoxin (Compound) and Digoxin may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Topiramate (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Topiramate (Compound) causes Accommodation disorder (Side Effect) and Accommodation disorder (Side Effect) is caused by Protriptyline (Compound) and Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine
Topiramate (Compound) causes Hallucination, visual (Side Effect) and Hallucination, visual (Side Effect) is caused by Pilocarpine (Compound) and Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with CHRM3 (Gene) and CHRM3 (Gene) is bound by Dicyclomine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Dicyclomine (Compound)
Topiramate (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Trichlormethiazide (Compound) and Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Digoxin (Compound) and Digoxin may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Zonisamide (Compound) and Zonisamide may lead to a major life threatening interaction when taken with Dicyclomine