DDInter1397 DDInter413
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease, It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin. Clopidogrel was granted FDA approval on 17 November 1997.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) downregulates {v} (Gene) ETFB
ETFB {u} (Gene) is downregulated by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) causes {v} (Side Effect) Deafness
Deafness {u} (Side Effect) is caused by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Clopidogrel
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) SQRDL
SQRDL {u} (Gene) is upregulated by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is regulated by {v} (Gene) SPRED2
SPRED2 {u} (Gene) is upregulated by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) downregulates {v} (Gene) ETFB
ETFB {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Clopidogrel
Paroxetine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clopidogrel
Paroxetine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Clopidogrel (Compound)
Paroxetine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Clopidogrel (Compound)
Paroxetine (Compound) downregulates ETFB (Gene) and ETFB (Gene) is downregulated by Clopidogrel (Compound)
Paroxetine (Compound) causes Deafness (Side Effect) and Deafness (Side Effect) is caused by Clopidogrel (Compound)
Paroxetine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates SQRDL (Gene) and SQRDL (Gene) is upregulated by Clopidogrel (Compound)
Paroxetine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is regulated by SPRED2 (Gene) and SPRED2 (Gene) is upregulated by Clopidogrel (Compound)
Paroxetine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Clopidogrel (Compound)
Paroxetine (Compound) downregulates ETFB (Gene) and ETFB (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Clopidogrel (Compound)
Paroxetine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Clopidogrel (Compound)