DDInter1042 DDInter854
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Halothane {u} (Compound) resembles {v} (Compound) Isoflurane
Halothane {u} (Compound) binds {v} (Gene) GRIN2A
Halothane {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prasugrel
Halothane {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Halothane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Halothane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Degarelix
Halothane {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Halothane {u} may lead to a major life threatening interaction when taken with {v} Cabozantinib
Halothane (Compound) resembles Isoflurane (Compound)
Halothane (Compound) binds GRIN2A (Gene)
Halothane may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Halothane may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Degarelix
Halothane may lead to a major life threatening interaction when taken with Cisapride
Halothane may lead to a major life threatening interaction when taken with Cabozantinib