DDInter460 DDInter150
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Cytarabine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Cytarabine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Cytarabine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Cytarabine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Cytarabine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Cytarabine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Cytarabine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Cytarabine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Azathioprine
Cytarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Tioguanine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Azathioprine
Cytarabine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Cytarabine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)
Cytarabine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is upregulated by Azathioprine (Compound)
Cytarabine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) and Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) includes Azathioprine (Compound)
Cytarabine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Azathioprine (Compound)
Cytarabine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Cytarabine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Cytarabine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Cytarabine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Azathioprine (Compound)
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Azathioprine (Compound)
Cytarabine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by RPIA (Gene) and RPIA (Gene) is downregulated by Azathioprine (Compound)