DDInter894 DDInter255
Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, hydroxyurea is used sparingly in clinical settings, largely due to lack of knowledge and adherence, the need for therapeutic monitoring, and serious side effects of secondary cancer and birth defects.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Hydroxyurea {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) resembles {v} (Compound) Acetohydroxamic acid
Acetohydroxamic acid {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) treats {v} (Disease) brain cancer
brain cancer {u} (Disease) is associated with {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) downregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) binds {v} (Gene) RRM1
RRM1 {u} (Gene) regulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) upregulates {v} (Gene) AURKB
AURKB {u} (Gene) is upregulated by {v} (Compound) Busulfan
Hydroxyurea {u} (Compound) binds {v} (Gene) RRM2
RRM2 {u} (Gene) is regulated by {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Hydroxyurea (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Hydroxyurea (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Hydroxyurea (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Hydroxyurea (Compound) resembles Acetohydroxamic acid (Compound) and Acetohydroxamic acid (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Busulfan (Compound)
Hydroxyurea (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Hydroxyurea (Compound) treats brain cancer (Disease) and brain cancer (Disease) is associated with MYC (Gene) and MYC (Gene) is downregulated by Busulfan (Compound)
Hydroxyurea (Compound) treats psoriasis (Disease) and psoriasis (Disease) downregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Busulfan (Compound)
Hydroxyurea (Compound) binds RRM1 (Gene) and RRM1 (Gene) regulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Busulfan (Compound)
Hydroxyurea (Compound) treats psoriasis (Disease) and psoriasis (Disease) upregulates AURKB (Gene) and AURKB (Gene) is upregulated by Busulfan (Compound)
Hydroxyurea (Compound) binds RRM2 (Gene) and RRM2 (Gene) is regulated by XBP1 (Gene) and XBP1 (Gene) is downregulated by Busulfan (Compound)