DDInter252 DDInter1798
Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. More specifically, bupropion binds to the norepinephrine transporter (NET) and the dopamine transporter (DAT).[A6399,A178810] Bupropion was originally classified as an "atypical" antidepressant because it does not exert the same effects as the classical antidepressants such as Monoamine Oxidase Inhibitors (MA
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Thiothixene
Bupropion {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Thiothixene
Bupropion {u} (Compound) downregulates {v} (Gene) STXBP1
STXBP1 {u} (Gene) is upregulated by {v} (Compound) Thiothixene
Bupropion {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Thiothixene
Bupropion {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Olopatadine
Olopatadine {u} (Compound) resembles {v} (Compound) Thiothixene
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Bupropion may lead to a major life threatening interaction when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Bupropion may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine (Compound) resembles Thiothixene (Compound)
Bupropion (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thiothixene (Compound)
Bupropion (Compound) downregulates STXBP1 (Gene) and STXBP1 (Gene) is upregulated by Thiothixene (Compound)
Bupropion (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Thiothixene (Compound)
Bupropion (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Thiothixene (Compound)
Bupropion may lead to a major life threatening interaction when taken with Doxepin and Doxepin (Compound) resembles Olopatadine (Compound) and Olopatadine (Compound) resembles Thiothixene (Compound)
Bupropion may lead to a major life threatening interaction when taken with Amitriptyline and Amitriptyline (Compound) resembles Doxepin (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Bupropion may lead to a major life threatening interaction when taken with Chlorpromazine and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Bupropion may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)