DDInter1678 DDInter434
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} (Compound) causes {v} (Side Effect) Protein urine present
Protein urine present {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistin
Colistin {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistin
Colistin {u} (Compound) resembles {v} (Compound) Colistimethate
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Bacitracin
Bacitracin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Sirolimus may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistimethate (Compound)
Sirolimus (Compound) causes Protein urine present (Side Effect) and Protein urine present (Side Effect) is caused by Colistimethate (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin (Compound) resembles Colistin (Compound) and Colistin (Compound) resembles Colistimethate (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Sirolimus (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Polymyxin B (Compound) and Polymyxin B (Compound) resembles Colistimethate (Compound)
Sirolimus (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Sirolimus (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistin (Compound) and Colistin (Compound) resembles Colistimethate (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Colistimethate (Compound)