DDInter1867 DDInter535
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Triflupromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) LPAR2
LPAR2 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) resembles {v} (Compound) Ethopropazine
Ethopropazine {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) resembles {v} (Compound) Desipramine
Desipramine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) regulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) resembles {v} (Compound) Perphenazine
Perphenazine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Triflupromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Diazoxide (Compound)
Triflupromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by LPAR2 (Gene) and LPAR2 (Gene) is upregulated by Diazoxide (Compound)
Triflupromazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Triflupromazine (Compound) resembles Ethopropazine (Compound) and Ethopropazine (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is downregulated by Diazoxide (Compound)
Triflupromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Diazoxide (Compound)
Triflupromazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Diazoxide (Compound)
Triflupromazine (Compound) resembles Desipramine (Compound) and Desipramine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Diazoxide (Compound)
Triflupromazine (Compound) downregulates CYCS (Gene) and CYCS (Gene) regulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Diazoxide (Compound)
Triflupromazine (Compound) resembles Perphenazine (Compound) and Perphenazine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Triflupromazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)