DDInter458 DDInter246
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) upregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is downregulated by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Paramethasone
Paramethasone {u} (Compound) resembles {v} (Compound) Budesonide
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Budesonide
Cyclosporine {u} (Compound) upregulates {v} (Gene) ATF6
ATF6 {u} (Gene) is regulated by {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Budesonide
Cyclosporine {u} (Compound) upregulates {v} (Gene) DHDDS
DHDDS {u} (Gene) is regulated by {v} (Gene) NR3C1
NR3C1 {u} (Gene) is bound by {v} (Compound) Budesonide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Budesonide (Compound)
Cyclosporine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Budesonide (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Budesonide (Compound)
Cyclosporine (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is downregulated by Budesonide (Compound)
Cyclosporine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Budesonide (Compound)
Cyclosporine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Budesonide (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paramethasone (Compound) and Paramethasone (Compound) resembles Budesonide (Compound)
Cyclosporine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Budesonide (Compound)
Cyclosporine (Compound) upregulates ATF6 (Gene) and ATF6 (Gene) is regulated by DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Budesonide (Compound)
Cyclosporine (Compound) upregulates DHDDS (Gene) and DHDDS (Gene) is regulated by NR3C1 (Gene) and NR3C1 (Gene) is bound by Budesonide (Compound)