DDInter216 DDInter1376
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Bisoprolol {u} (Compound) resembles {v} (Compound) Acebutolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Bevantolol
Bisoprolol {u} (Compound) binds {v} (Gene) CYP2D6
Bisoprolol {u} (Compound) causes {v} (Side Effect) Oropharyngeal pain
Bisoprolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Bisoprolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Bisoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Bisoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Bisoprolol {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Bisoprolol {u} may lead to a major life threatening interaction when taken with {v} Theophylline
Bisoprolol (Compound) resembles Acebutolol (Compound)
Bisoprolol (Compound) resembles Bevantolol (Compound)
Bisoprolol (Compound) binds CYP2D6 (Gene)
Bisoprolol (Compound) causes Oropharyngeal pain (Side Effect)
Bisoprolol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Bisoprolol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone
Bisoprolol may lead to a major life threatening interaction when taken with Dolasetron
Bisoprolol may lead to a major life threatening interaction when taken with Theophylline