DDInter686 DDInter1016
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Etacrynic acid {u} (Compound) treats {v} (Disease) hypertension
Etacrynic acid {u} (Compound) binds {v} (Gene) SLC12A1
Etacrynic acid {u} (Compound) upregulates {v} (Gene) CTSL
Etacrynic acid {u} (Compound) palliates {v} (Disease) chronic kidney failure
Etacrynic acid {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis at Loop of Henle
Etacrynic acid {u} (Compound) downregulates {v} (Gene) PLK1
Etacrynic acid {u} (Compound) causes {v} (Side Effect) Hypoglycaemia
Etacrynic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Oxytetracycline
Etacrynic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Etacrynic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pramlintide
Etacrynic acid (Compound) treats hypertension (Disease)
Etacrynic acid (Compound) binds SLC12A1 (Gene)
Etacrynic acid (Compound) upregulates CTSL (Gene)
Etacrynic acid (Compound) palliates chronic kidney failure (Disease)
Etacrynic acid (Compound) is included by Increased Diuresis at Loop of Henle (Pharmacologic Class)
Etacrynic acid (Compound) downregulates PLK1 (Gene)
Etacrynic acid (Compound) causes Hypoglycaemia (Side Effect)
Etacrynic acid may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline
Etacrynic acid may cause a minor interaction that can limit clinical effects when taken with Minocycline
Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide