DDInter1619 DDInter1168
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Ropinirole {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) is bound by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Ropinirole {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Ropinirole {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Methyldopa
Methyldopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ropinirole {u} (Compound) causes {v} (Side Effect) Eye irritation
Eye irritation {u} (Side Effect) is caused by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Ropinirole {u} (Compound) causes {v} (Side Effect) Eye irritation
Eye irritation {u} (Side Effect) is caused by {v} (Compound) Sotalol
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Methdilazine
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Chlorpromazine
Chlorpromazine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ropinirole (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Ropinirole (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Ropinirole (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ropinirole (Compound) causes Eye irritation (Side Effect) and Eye irritation (Side Effect) is caused by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Ropinirole (Compound) causes Eye irritation (Side Effect) and Eye irritation (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Methdilazine
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Chlorpromazine (Compound) and Chlorpromazine (Compound) resembles Methdilazine (Compound) and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine