DDInter1244 DDInter1845
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tranylcypromine
Morphine {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Tranylcypromine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Phenmetrazine
Phenmetrazine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} may lead to a major life threatening interaction when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Tranylcypromine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Tranylcypromine (Compound)
Morphine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Tranylcypromine (Compound)
Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tranylcypromine (Compound)
Morphine (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Tranylcypromine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Phenmetrazine (Compound) and Phenmetrazine (Compound) resembles Tranylcypromine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound) and Ethotoin (Compound) resembles Tranylcypromine (Compound)
Morphine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine may lead to a major life threatening interaction when taken with Phentermine and Phentermine (Compound) resembles Tranylcypromine (Compound)
Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Tranylcypromine (Compound)
Morphine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)