DDInter908 DDInter856
Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Iloprost {u} (Compound) resembles {v} (Compound) Bimatoprost
Iloprost {u} (Compound) binds {v} (Gene) PDE4D
Iloprost {u} (Compound) is included by {v} (Pharmacologic Class) Prostaglandins I
Iloprost {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capsicum
Iloprost {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethaphan
Iloprost {u} may lead to a major life threatening interaction when taken with {v} Betrixaban
Iloprost {u} may lead to a major life threatening interaction when taken with {v} Ibritumomab tiuxetan
Iloprost (Compound) resembles Bimatoprost (Compound)
Iloprost (Compound) binds PDE4D (Gene)
Iloprost (Compound) is included by Prostaglandins I (Pharmacologic Class)
Iloprost may cause a minor interaction that can limit clinical effects when taken with Capsicum
Iloprost may cause a minor interaction that can limit clinical effects when taken with Tadalafil
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Trimethaphan
Iloprost may lead to a major life threatening interaction when taken with Betrixaban
Iloprost may lead to a major life threatening interaction when taken with Ibritumomab tiuxetan