DDInter292 DDInter902
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B<sub>2</sub> receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B<sub>2</sub> receptors antagonists, thus representing a new class of medication.[A4017,A263041] It was investigated as a potential treatment of hereditary angioedema (HAE) as bradykinin was implicated in HAE swelling; specifically, mice lacking B<sub>2</sub> receptors showed reduced swelling, thus demonstrating bradykinin involvement in the disease pathophysiology.[A4017,A263046] Icatibant was approved by the FDA on August 25, 2011, and by the EMA in 2008 as a treatment for hereditary angioedema.[L49776,L49781] The FDA approval was based on positive results obtained from 3 double-blind, randomized, controlled clinical trials known as FAST 1, 2, and 3, where a median time to almost complete symptom relief was observed to be 8 hours compared to 36 hours for the placebo treatment.
Captopril {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Icatibant
Captopril {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Goserelin
Goserelin {u} (Compound) resembles {v} (Compound) Icatibant
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alogliptin
Alogliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Goserelin
Goserelin {u} (Compound) resembles {v} (Compound) Icatibant
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alogliptin
Alogliptin {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Icatibant
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Goserelin
Goserelin {u} (Compound) resembles {v} (Compound) Icatibant
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Glipizide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Icatibant
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Magnesium hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Goserelin
Goserelin {u} (Compound) resembles {v} (Compound) Icatibant
Captopril {u} (Compound) downregulates {v} (Gene) USP22
USP22 {u} (Gene) is regulated by {v} (Gene) ANPEP
ANPEP {u} (Gene) is bound by {v} (Compound) Icatibant
Captopril {u} (Compound) binds {v} (Gene) ACE
ACE {u} (Gene) interacts with {v} (Gene) BDKRB2
BDKRB2 {u} (Gene) is bound by {v} (Compound) Icatibant
Captopril {u} (Compound) treats {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is associated with {v} (Gene) BDKRB2
BDKRB2 {u} (Gene) is bound by {v} (Compound) Icatibant
Captopril (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Icatibant (Compound)
Captopril (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Goserelin (Compound) and Goserelin (Compound) resembles Icatibant (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Icatibant (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Icatibant (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Icatibant (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Icatibant (Compound)
Captopril may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide and Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Icatibant (Compound)
Captopril (Compound) downregulates USP22 (Gene) and USP22 (Gene) is regulated by ANPEP (Gene) and ANPEP (Gene) is bound by Icatibant (Compound)
Captopril (Compound) binds ACE (Gene) and ACE (Gene) interacts with BDKRB2 (Gene) and BDKRB2 (Gene) is bound by Icatibant (Compound)
Captopril (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is associated with BDKRB2 (Gene) and BDKRB2 (Gene) is bound by Icatibant (Compound)