DDInter1123 DDInter958
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Mannitol {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Iodixanol
Mannitol {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Polythiazide
Polythiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodixanol
Mannitol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Iohexol
Iohexol {u} (Compound) resembles {v} (Compound) Iodixanol
Mannitol {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodixanol
Mannitol {u} (Compound) resembles {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Iodixanol
Mannitol {u} (Compound) causes {v} (Side Effect) Acidosis
Acidosis {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may lead to a major life threatening interaction when taken with {v} Iodixanol
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Iodixanol
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Timolol
Timolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodixanol
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Iodixanol
Mannitol {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Amiloride
Amiloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodixanol
Mannitol (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Mannitol (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Polythiazide (Compound) and Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol
Mannitol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Iohexol (Compound) and Iohexol (Compound) resembles Iodixanol (Compound)
Mannitol (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol
Mannitol (Compound) resembles Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Iodixanol (Compound)
Mannitol (Compound) causes Acidosis (Side Effect) and Acidosis (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may lead to a major life threatening interaction when taken with Iodixanol
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Iodixanol
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Timolol (Compound) and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Iodixanol (Compound)
Mannitol (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Amiloride (Compound) and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol