DDInter181 DDInter690
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine. Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Benzatropine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine {u} (Compound) resembles {v} (Compound) Benzphetamine
Benzphetamine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine {u} (Compound) resembles {v} (Compound) Cinnarizine
Cinnarizine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is associated with {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cyclizine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Ethanol
Benzatropine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Benzatropine (Compound) resembles Benzphetamine (Compound) and Benzphetamine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Benzatropine (Compound) resembles Cinnarizine (Compound) and Cinnarizine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Benzatropine (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is associated with CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ethanol (Compound)
Benzatropine (Compound) resembles Cyclizine (Compound) and Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ethanol (Compound)
Benzatropine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Ethanol (Compound)