DDInter548 DDInter1627
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Diethylstilbestrol {u} (Compound) binds {v} (Gene) TTR
TTR {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR2
ESR2 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Diethylstilbestrol {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) SCN9A
SCN9A {u} (Gene) is bound by {v} (Compound) Rufinamide
Diethylstilbestrol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Rufinamide (Compound)
Diethylstilbestrol (Compound) binds TTR (Gene) and TTR (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)
Diethylstilbestrol (Compound) binds ESR2 (Gene) and ESR2 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Diethylstilbestrol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Diethylstilbestrol (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by SCN9A (Gene) and SCN9A (Gene) is bound by Rufinamide (Compound)