DDInter1938 DDInter1840
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Vincristine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Vincristine {u} (Compound) downregulates {v} (Gene) DNM1
DNM1 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) upregulates {v} (Gene) AXL
AXL {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) upregulates {v} (Gene) DLGAP4
DLGAP4 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) treats {v} (Disease) colon cancer
colon cancer {u} (Disease) is associated with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) treats {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) downregulates {v} (Gene) DTL
DTL {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) upregulates {v} (Gene) RALA
RALA {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine {u} (Compound) upregulates {v} (Gene) DAXX
DAXX {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Vincristine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Trabectedin (Compound)
Vincristine (Compound) downregulates DNM1 (Gene) and DNM1 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) upregulates AXL (Gene) and AXL (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) upregulates DLGAP4 (Gene) and DLGAP4 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) treats colon cancer (Disease) and colon cancer (Disease) is associated with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) treats colon cancer (Disease) and colon cancer (Disease) downregulates PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) downregulates DTL (Gene) and DTL (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) upregulates RALA (Gene) and RALA (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Vincristine (Compound) upregulates DAXX (Gene) and DAXX (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)