DDInter1442 DDInter178
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Phenobarbital {u} (Compound) resembles {v} (Compound) Primidone
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Phenobarbital {u} (Compound) treats {v} (Disease) epilepsy syndrome
Phenobarbital {u} (Compound) binds {v} (Gene) ABCC3
Phenobarbital {u} (Compound) causes {v} (Side Effect) Mental disability
Phenobarbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomustine
Phenobarbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Letrozole
Phenobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Phenobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Phenobarbital {u} may lead to a major life threatening interaction when taken with {v} Sunitinib
Phenobarbital (Compound) resembles Primidone (Compound)
Phenobarbital (Compound) resembles Methsuximide (Compound)
Phenobarbital (Compound) treats epilepsy syndrome (Disease)
Phenobarbital (Compound) binds ABCC3 (Gene)
Phenobarbital (Compound) causes Mental disability (Side Effect)
Phenobarbital may cause a minor interaction that can limit clinical effects when taken with Lomustine
Phenobarbital may cause a minor interaction that can limit clinical effects when taken with Letrozole
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Phenobarbital may lead to a major life threatening interaction when taken with Sunitinib