DDInter1705 DDInter1016
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Sparfloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Sparfloxacin {u} (Compound) binds {v} (Gene) SLC22A5
Sparfloxacin {u} (Compound) upregulates {v} (Gene) KCTD5
Sparfloxacin {u} (Compound) downregulates {v} (Gene) PKIG
Sparfloxacin {u} (Compound) causes {v} (Side Effect) Atrial flutter
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Temozolomide
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Paclitaxel
Sparfloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zinc sulfate
Sparfloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Sparfloxacin {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Sparfloxacin (Compound) binds SLC22A5 (Gene)
Sparfloxacin (Compound) upregulates KCTD5 (Gene)
Sparfloxacin (Compound) downregulates PKIG (Gene)
Sparfloxacin (Compound) causes Atrial flutter (Side Effect)
Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Temozolomide
Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Paclitaxel
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Zinc sulfate
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Sparfloxacin may lead to a major life threatening interaction when taken with Vandetanib