DDInter1381 DDInter1016
Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006. It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.[L16168,L37744,L4137,L37749]
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Paliperidone {u} (Compound) resembles {v} (Compound) Risperidone
Paliperidone {u} (Compound) binds {v} (Gene) DRD2
Paliperidone {u} (Compound) palliates {v} (Disease) schizophrenia
Paliperidone {u} (Compound) causes {v} (Side Effect) Skin discolouration
Paliperidone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Paliperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eribulin
Paliperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Paliperidone {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Paliperidone {u} may lead to a major life threatening interaction when taken with {v} Vemurafenib
Paliperidone (Compound) resembles Risperidone (Compound)
Paliperidone (Compound) binds DRD2 (Gene)
Paliperidone (Compound) palliates schizophrenia (Disease)
Paliperidone (Compound) causes Skin discolouration (Side Effect)
Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide
Paliperidone may lead to a major life threatening interaction when taken with Metoclopramide
Paliperidone may lead to a major life threatening interaction when taken with Vemurafenib