DDInter1124 DDInter535
Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Maprotiline {u} (Compound) downregulates {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Maprotiline {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Maprotiline {u} (Compound) downregulates {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) regulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Maprotiline {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Maprotiline {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Maprotiline {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Maprotiline {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Maprotiline {u} (Compound) downregulates {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) is regulated by {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Maprotiline (Compound) downregulates ITGB1BP1 (Gene) and ITGB1BP1 (Gene) is downregulated by Diazoxide (Compound)
Maprotiline (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Diazoxide (Compound)
Maprotiline (Compound) downregulates ITGB1BP1 (Gene) and ITGB1BP1 (Gene) regulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Diazoxide (Compound)
Maprotiline (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Maprotiline (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is upregulated by Diazoxide (Compound)
Maprotiline (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Maprotiline (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Maprotiline (Compound) downregulates ITGB1BP1 (Gene) and ITGB1BP1 (Gene) is regulated by EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Diazoxide (Compound)
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)