DDInter1018 DDInter624
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and its first clinical use for treating PSE was not until 1966. Nevertheless, although lactulose received formal FDA approval in 1977 and has since become a readily available generic and brand-name non-prescription medication listed on the World Health Organization's List of Essential Medicines as one of the most effective and safe medicines employed in a health system, data regarding its optimal place in therapy is often ambiguous. Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Lactulose {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Lactulose {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Lactulose {u} (Compound) resembles {v} (Compound) Acarbose
Acarbose {u} (Compound) causes {v} (Side Effect) Immune system disorder
Immune system disorder {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Lactulose {u} (Compound) resembles {v} (Compound) Glucosamine
Glucosamine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Lactulose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Neomycin
Neomycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perflutren
Perflutren {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Sorafenib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Efavirenz
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ofloxacin
Ofloxacin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Efavirenz
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) upregulates {v} (Gene) TBX2
TBX2 {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ofloxacin
Ofloxacin {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Lactulose (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Efavirenz (Compound)
Lactulose (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Efavirenz (Compound)
Lactulose (Compound) resembles Acarbose (Compound) and Acarbose (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Efavirenz (Compound)
Lactulose (Compound) resembles Glucosamine (Compound) and Glucosamine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)
Lactulose may cause a minor interaction that can limit clinical effects when taken with Neomycin and Neomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Efavirenz (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Efavirenz (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Efavirenz (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Efavirenz (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) upregulates TBX2 (Gene) and TBX2 (Gene) is upregulated by Efavirenz (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Efavirenz (Compound)