DDInter350 DDInter351
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.[L43942,L44022]
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is downregulated by {v} (Compound) Chloramphenicol
Chlorambucil {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Chlorambucil {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Chlorambucil {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) regulates {v} (Gene) PHKG2
PHKG2 {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Chlorambucil {u} (Compound) causes {v} (Side Effect) Neuritis
Neuritis {u} (Side Effect) is caused by {v} (Compound) Estradiol
Estradiol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Chlorambucil (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Chloramphenicol (Compound)
Chlorambucil (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Chloramphenicol (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Chlorambucil (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Chloramphenicol (Compound)
Chlorambucil (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Chlorambucil (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Chloramphenicol (Compound)
Chlorambucil (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) regulates PHKG2 (Gene) and PHKG2 (Gene) is upregulated by Chloramphenicol (Compound)
Chlorambucil (Compound) causes Neuritis (Side Effect) and Neuritis (Side Effect) is caused by Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol