DDInter1119 DDInter1658
Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Magnesium oxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lisinopril
Magnesium oxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Magnesium oxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delafloxacin
Magnesium oxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Magnesium oxide {u} may lead to a major life threatening interaction when taken with {v} Bictegravir
Magnesium oxide {u} may lead to a major life threatening interaction when taken with {v} Tolevamer
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Lisinopril
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Magnesium oxide may lead to a major life threatening interaction when taken with Bictegravir
Magnesium oxide may lead to a major life threatening interaction when taken with Tolevamer