DDInter856 DDInter645
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Enoxaparin {u} (Compound) binds {v} (Gene) SERPINC1
Enoxaparin {u} (Compound) is included by {v} (Pharmacologic Class) Heparin, Low-Molecular-Weight
Enoxaparin {u} (Compound) causes {v} (Side Effect) Epidural haemorrhage
Enoxaparin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Enoxaparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenyl salicylate
Enoxaparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valdecoxib
Enoxaparin {u} may lead to a major life threatening interaction when taken with {v} Dipyridamole
Enoxaparin {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Enoxaparin (Compound) binds SERPINC1 (Gene)
Enoxaparin (Compound) is included by Heparin, Low-Molecular-Weight (Pharmacologic Class)
Enoxaparin (Compound) causes Epidural haemorrhage (Side Effect)
Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Turmeric
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Enoxaparin may lead to a major life threatening interaction when taken with Dipyridamole
Enoxaparin may lead to a major life threatening interaction when taken with Vorapaxar