DDInter1515 DDInter1763
A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Prednisone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Prednisone {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Prednisone {u} (Compound) upregulates {v} (Gene) RPP38
RPP38 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Prednisone {u} (Compound) downregulates {v} (Gene) ZDHHC6
ZDHHC6 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Prednisone {u} (Compound) causes {v} (Side Effect) Febrile neutropenia
Febrile neutropenia {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Prednisone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Prednisone {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is regulated by {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Prednisone {u} (Compound) upregulates {v} (Gene) RPP38
RPP38 {u} (Gene) regulates {v} (Gene) CDK19
CDK19 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Prednisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Prednisone (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Temsirolimus (Compound)
Prednisone (Compound) upregulates RPP38 (Gene) and RPP38 (Gene) is downregulated by Temsirolimus (Compound)
Prednisone (Compound) downregulates ZDHHC6 (Gene) and ZDHHC6 (Gene) is downregulated by Temsirolimus (Compound)
Prednisone (Compound) causes Febrile neutropenia (Side Effect) and Febrile neutropenia (Side Effect) is caused by Temsirolimus (Compound)
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Prednisone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Prednisone (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is regulated by PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Temsirolimus (Compound)
Prednisone (Compound) upregulates RPP38 (Gene) and RPP38 (Gene) regulates CDK19 (Gene) and CDK19 (Gene) is upregulated by Temsirolimus (Compound)