DDInter757 DDInter1676
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Fluorouracil {u} (Compound) resembles {v} (Compound) Uracil mustard
Fluorouracil {u} (Compound) treats {v} (Disease) head and neck cancer
Fluorouracil {u} (Compound) binds {v} (Gene) CYP2C8
Fluorouracil {u} (Compound) upregulates {v} (Gene) SERPINA3
Fluorouracil {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Fluorouracil {u} (Compound) downregulates {v} (Gene) PTPRO
Fluorouracil {u} (Compound) causes {v} (Side Effect) Ventricular septal defect
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Fluorouracil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Temozolomide
Fluorouracil (Compound) resembles Uracil mustard (Compound)
Fluorouracil (Compound) treats head and neck cancer (Disease)
Fluorouracil (Compound) binds CYP2C8 (Gene)
Fluorouracil (Compound) upregulates SERPINA3 (Gene)
Fluorouracil (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Fluorouracil (Compound) downregulates PTPRO (Gene)
Fluorouracil (Compound) causes Ventricular septal defect (Side Effect)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide