DDInter350 DDInter904
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) upregulates {v} (Gene) TRIM22
TRIM22 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) upregulates {v} (Gene) TRIM22
TRIM22 {u} (Gene) is regulated by {v} (Gene) KIT
KIT {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) upregulates {v} (Gene) GADD45A
GADD45A {u} (Gene) regulates {v} (Gene) FUT1
FUT1 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Chlorambucil {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Idarubicin
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Idarubicin (Compound)
Chlorambucil (Compound) upregulates TRIM22 (Gene) and TRIM22 (Gene) is upregulated by Idarubicin (Compound)
Chlorambucil (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Idarubicin (Compound)
Chlorambucil (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Idarubicin (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Chlorambucil (Compound) upregulates TRIM22 (Gene) and TRIM22 (Gene) is regulated by KIT (Gene) and KIT (Gene) is upregulated by Idarubicin (Compound)
Chlorambucil (Compound) upregulates GADD45A (Gene) and GADD45A (Gene) regulates FUT1 (Gene) and FUT1 (Gene) is upregulated by Idarubicin (Compound)
Chlorambucil (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Chlorambucil (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Idarubicin (Compound)