DDInter1873 DDInter1747
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Bevantolol
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Cisapride
Trimethobenzamide {u} (Compound) upregulates {v} (Gene) HIST1H2BK
Trimethobenzamide {u} (Compound) is included by {v} (Pharmacologic Class) Emesis Suppression
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Disorientation
Trimethobenzamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midazolam
Trimethobenzamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Trimethobenzamide {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Trimethobenzamide (Compound) resembles Bevantolol (Compound)
Trimethobenzamide (Compound) resembles Cisapride (Compound)
Trimethobenzamide (Compound) upregulates HIST1H2BK (Gene)
Trimethobenzamide (Compound) is included by Emesis Suppression (Pharmacologic Class)
Trimethobenzamide (Compound) causes Disorientation (Side Effect)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Midazolam
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine
Trimethobenzamide may lead to a major life threatening interaction when taken with Dextropropoxyphene