DDInter1018 DDInter790
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and its first clinical use for treating PSE was not until 1966. Nevertheless, although lactulose received formal FDA approval in 1977 and has since become a readily available generic and brand-name non-prescription medication listed on the World Health Organization's List of Essential Medicines as one of the most effective and safe medicines employed in a health system, data regarding its optimal place in therapy is often ambiguous. Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Lactulose {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Furosemide
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Bumetanide {u} (Compound) resembles {v} (Compound) Furosemide
Lactulose {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Lactulose {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Furosemide
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Furosemide
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) binds {v} (Gene) CA5A
CA5A {u} (Gene) is bound by {v} (Compound) Furosemide
Lactulose {u} (Compound) resembles {v} (Compound) Acarbose
Acarbose {u} (Compound) causes {v} (Side Effect) Immune system disorder
Immune system disorder {u} (Side Effect) is caused by {v} (Compound) Furosemide
Lactulose {u} (Compound) resembles {v} (Compound) Acarbose
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Lactulose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Neomycin
Neomycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Furosemide
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Furosemide (Compound)
Lactulose (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Furosemide (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Bumetanide (Compound) and Bumetanide (Compound) resembles Furosemide (Compound)
Lactulose (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Furosemide (Compound)
Lactulose (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Furosemide (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Furosemide (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) binds CA5A (Gene) and CA5A (Gene) is bound by Furosemide (Compound)
Lactulose (Compound) resembles Acarbose (Compound) and Acarbose (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Furosemide (Compound)
Lactulose (Compound) resembles Acarbose (Compound) and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Furosemide (Compound)
Lactulose may cause a minor interaction that can limit clinical effects when taken with Neomycin and Neomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Furosemide (Compound)