DDInter1764 DDInter899
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Tenecteplase {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxetine
Tenecteplase {u} may lead to a major life threatening interaction when taken with {v} Defibrotide
Tenecteplase {u} may lead to a major life threatening interaction when taken with {v} Lepirudin
Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine
Tenecteplase may lead to a major life threatening interaction when taken with Defibrotide
Tenecteplase may lead to a major life threatening interaction when taken with Lepirudin