DDInter1300 DDInter1397
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Nitisinone {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nilutamide {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) downregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) binds {v} (Gene) HPD
HPD {u} (Gene) interacts with {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Nitisinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Modafinil {u} (Compound) binds {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) binds {v} (Gene) HPD
HPD {u} (Gene) regulates {v} (Gene) FDPS
FDPS {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nilutamide {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Nateglinide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Nitisinone (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Paroxetine (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Paroxetine (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound) and Nilutamide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Paroxetine (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Paroxetine (Compound)
Nitisinone (Compound) binds HPD (Gene) and HPD (Gene) interacts with CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Paroxetine (Compound)
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Paroxetine (Compound)
Nitisinone (Compound) binds HPD (Gene) and HPD (Gene) regulates FDPS (Gene) and FDPS (Gene) is upregulated by Paroxetine (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound) and Nilutamide (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Paroxetine (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Paroxetine (Compound)