DDInter743 DDInter1853
Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Tretinoin
Fluconazole {u} (Compound) downregulates {v} (Gene) HOXA5
HOXA5 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Fluconazole {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Fluconazole {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Fluconazole {u} (Compound) downregulates {v} (Gene) HOXA5
HOXA5 {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Fluconazole {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Fluconazole {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Fluconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) interacts with {v} (Gene) PSMB8
PSMB8 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Tretinoin (Compound)
Fluconazole (Compound) downregulates HOXA5 (Gene) and HOXA5 (Gene) is upregulated by Tretinoin (Compound)
Fluconazole (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Tretinoin (Compound)
Fluconazole (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Tretinoin (Compound)
Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tretinoin (Compound)
Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Fluconazole (Compound) downregulates HOXA5 (Gene) and HOXA5 (Gene) is upregulated by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Fluconazole (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Fluconazole (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) interacts with PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Tretinoin (Compound)