DDInter458 DDInter916
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a number of lifestyle changes (ie. reduced sodium intake) along with pharmacotherapy - it should be noted that treatment with several antihypertensive agents may be required in order to achieve blood pressure targets. Thiazide-like diuretics such as indapamide are a valuable tool for the treatment of hypertension and continue to grow in popularity, falling behind only ACE inhibitors in terms of prescription frequency. When compared to [hydrochlorothiazide] (another commonly prescribed diuretic), indapamide has been shown to be superior at lowering systolic blood pressure, reducing left ventricular mass index, lowering oxidative stress, inhibiting platelet aggregation, and reducing microalbuminuria associated with diabetes. Interestingly, unlike thiazide diuretics, several sources suggest that indapamide is not associated with glucose or lipid disturbances.[A204134,A204161] Indapamide is characterized by both a methylindoline and a sulfamoyl chlorobenzamide functional group, with the former being largely responsible for the molecule’s lipid solubility.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myopathy
Myopathy {u} (Side Effect) is caused by {v} (Compound) Indapamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myopathy
Myopathy {u} (Side Effect) is caused by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Libido decreased
Libido decreased {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Chlorthalidone
Chlorthalidone {u} (Compound) resembles {v} (Compound) Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Depression
Depression {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastroenteritis
Gastroenteritis {u} (Side Effect) is caused by {v} (Compound) Glycopyrronium
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Indapamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Candida infection
Candida infection {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxycycline
Doxycycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Indapamide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Indapamide (Compound)
Cyclosporine (Compound) causes Myopathy (Side Effect) and Myopathy (Side Effect) is caused by Indapamide (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxcarbazepine (Compound) and Oxcarbazepine (Compound) resembles Indapamide (Compound)
Cyclosporine (Compound) causes Myopathy (Side Effect) and Myopathy (Side Effect) is caused by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Indapamide
Cyclosporine (Compound) causes Libido decreased (Side Effect) and Libido decreased (Side Effect) is caused by Oxcarbazepine (Compound) and Oxcarbazepine (Compound) resembles Indapamide (Compound)
Cyclosporine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Chlorthalidone (Compound) and Chlorthalidone (Compound) resembles Indapamide (Compound)
Cyclosporine (Compound) causes Depression (Side Effect) and Depression (Side Effect) is caused by Atropine (Compound) and Atropine may cause a minor interaction that can limit clinical effects when taken with Indapamide
Cyclosporine (Compound) causes Gastroenteritis (Side Effect) and Gastroenteritis (Side Effect) is caused by Glycopyrronium (Compound) and Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Indapamide
Cyclosporine (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Indapamide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound) and Doxycycline may cause a minor interaction that can limit clinical effects when taken with Indapamide