DDInter1232 DDInter1259
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discovered that work via this alkylating mechanism, making mitomycin relatively unique in the space of microbiota-derived therapies. Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper Tract Urothelial Cancer (LG-UTUC) - as well as adjunctly to _ab externo_ glaucoma surgeries.
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Nalidixic acid
Mitomycin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Nalidixic acid
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Rosoxacin
Rosoxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Gemifloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Pefloxacin
Pefloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Nalidixic acid (Compound)
Mitomycin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nalidixic acid (Compound)
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Rosoxacin (Compound) and Rosoxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Enoxacin (Compound) and Enoxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Pefloxacin (Compound) and Pefloxacin (Compound) resembles Nalidixic acid (Compound)