DDInter893 DDInter125
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of [quinacrine] with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.** Hydroxychloroquine was granted FDA approval on 18 April 1955.
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Hydroxychloroquine {u} may lead to a major life threatening interaction when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Asenapine
Hydroxychloroquine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Hydroxychloroquine {u} may lead to a major life threatening interaction when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine {u} may lead to a major life threatening interaction when taken with {v} Amoxapine
Amoxapine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Hydroxychloroquine {u} may lead to a major life threatening interaction when taken with {v} Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olanzapine
Olanzapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olanzapine
Olanzapine {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Hydroxychloroquine may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine (Compound) resembles Asenapine (Compound)
Hydroxychloroquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Asenapine (Compound)
Hydroxychloroquine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Hydroxychloroquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Amoxapine (Compound) and Amoxapine (Compound) resembles Asenapine (Compound)
Hydroxychloroquine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) resembles Asenapine (Compound)