DDInter336 DDInter686
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Etacrynic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypoglycaemia
Hypoglycaemia {u} (Side Effect) is caused by {v} (Compound) Etacrynic acid
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Etacrynic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypoglycaemia
Hypoglycaemia {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Etacrynic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etacrynic acid
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) interacts with {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Etacrynic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Blood uric acid increased
Blood uric acid increased {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etacrynic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) regulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Etacrynic acid
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Etacrynic acid
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is associated with {v} (Gene) GSTA2
GSTA2 {u} (Gene) is bound by {v} (Compound) Etacrynic acid
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Etacrynic acid (Compound)
Celecoxib (Compound) causes Hypoglycaemia (Side Effect) and Hypoglycaemia (Side Effect) is caused by Etacrynic acid (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Etacrynic acid (Compound)
Celecoxib (Compound) causes Hypoglycaemia (Side Effect) and Hypoglycaemia (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Etacrynic acid
Celecoxib (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Etacrynic acid
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) interacts with CTSL (Gene) and CTSL (Gene) is upregulated by Etacrynic acid (Compound)
Celecoxib (Compound) causes Blood uric acid increased (Side Effect) and Blood uric acid increased (Side Effect) is caused by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Etacrynic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) regulates CTSL (Gene) and CTSL (Gene) is upregulated by Etacrynic acid (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Etacrynic acid (Compound)
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is associated with GSTA2 (Gene) and GSTA2 (Gene) is bound by Etacrynic acid (Compound)