DDInter255 DDInter1156
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Busulfan {u} (Compound) causes {v} (Side Effect) Hyperuricosuria
Hyperuricosuria {u} (Side Effect) is caused by {v} (Compound) Mercaptopurine
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Busulfan {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Trovafloxacin
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Busulfan {u} (Compound) causes {v} (Side Effect) Cytopenia
Cytopenia {u} (Side Effect) is caused by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Busulfan {u} (Compound) causes {v} (Side Effect) Hepatic necrosis
Hepatic necrosis {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Busulfan {u} (Compound) upregulates {v} (Gene) GLOD4
GLOD4 {u} (Gene) is downregulated by {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Busulfan {u} (Compound) causes {v} (Side Effect) Cytopenia
Cytopenia {u} (Side Effect) is caused by {v} (Compound) Fludarabine
Fludarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Busulfan {u} (Compound) downregulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is downregulated by {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Busulfan (Compound) causes Hyperuricosuria (Side Effect) and Hyperuricosuria (Side Effect) is caused by Mercaptopurine (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Methotrexate (Compound) and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Busulfan (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Trovafloxacin (Compound) and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Busulfan (Compound) causes Cytopenia (Side Effect) and Cytopenia (Side Effect) is caused by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Busulfan (Compound) causes Hepatic necrosis (Side Effect) and Hepatic necrosis (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Busulfan (Compound) upregulates GLOD4 (Gene) and GLOD4 (Gene) is downregulated by Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Busulfan (Compound) causes Cytopenia (Side Effect) and Cytopenia (Side Effect) is caused by Fludarabine (Compound) and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Busulfan (Compound) downregulates BLCAP (Gene) and BLCAP (Gene) is downregulated by Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)