DDInter655 DDInter150
An anthracycline which is the 4&#39;-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Epirubicin {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) upregulates {v} (Gene) ADAT1
ADAT1 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Epirubicin {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Epirubicin (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Epirubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Epirubicin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Epirubicin (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Epirubicin (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Azathioprine (Compound)
Epirubicin (Compound) upregulates ADAT1 (Gene) and ADAT1 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Epirubicin (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Epirubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Epirubicin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Epirubicin (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)