DDInter1008 DDInter1059
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue
Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interconversion between levomilnacipran and its stereoisomer does not occur in humans. First approved by the FDA on July 25, 2013, levomilnacipran is used to treat major depressive disorder in adults. While levomilnacipran was previously investigated and proposed as a potential treatment for stroke in Europe, the EMA decided against this use.
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levomilnacipran
Ketoconazole {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Milnacipran
Milnacipran {u} (Compound) resembles {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) resembles {v} (Compound) Itraconazole
Itraconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levomilnacipran
Ketoconazole {u} (Compound) resembles {v} (Compound) Terconazole
Terconazole {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) resembles {v} (Compound) Posaconazole
Posaconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levomilnacipran
Ketoconazole {u} (Compound) causes {v} (Side Effect) Dry eye
Dry eye {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may lead to a major life threatening interaction when taken with {v} Levomilnacipran
Ketoconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Levomilnacipran (Compound)
Ketoconazole (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Levomilnacipran (Compound)
Ketoconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Meperidine (Compound) and Meperidine (Compound) resembles Levomilnacipran (Compound)
Ketoconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound) and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran
Ketoconazole (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Milnacipran (Compound) and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Ketoconazole (Compound) resembles Itraconazole (Compound) and Itraconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levomilnacipran (Compound)
Ketoconazole (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran
Ketoconazole (Compound) resembles Terconazole (Compound) and Terconazole (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Levomilnacipran (Compound)
Ketoconazole (Compound) resembles Posaconazole (Compound) and Posaconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levomilnacipran (Compound)
Ketoconazole (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may lead to a major life threatening interaction when taken with Levomilnacipran