DDInter675 DDInter581
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors.
Esmolol {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Dolasetron
Esmolol {u} (Compound) causes {v} (Side Effect) Oliguria
Oliguria {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Esmolol {u} (Compound) resembles {v} (Compound) Pindolol
Pindolol {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Esmolol {u} (Compound) resembles {v} (Compound) Bisoprolol
Bisoprolol {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Esmolol {u} (Compound) resembles {v} (Compound) Acebutolol
Acebutolol {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Esmolol {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is regulated by {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Dolasetron
Esmolol {u} (Compound) causes {v} (Side Effect) Oliguria
Oliguria {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dolasetron
Esmolol {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Hyoscyamine
Hyoscyamine {u} (Compound) resembles {v} (Compound) Dolasetron
Esmolol {u} (Compound) causes {v} (Side Effect) Peripheral ischaemia
Peripheral ischaemia {u} (Side Effect) is caused by {v} (Compound) Bisoprolol
Bisoprolol {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Esmolol {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dolasetron
Esmolol (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Dolasetron (Compound)
Esmolol (Compound) causes Oliguria (Side Effect) and Oliguria (Side Effect) is caused by Dolasetron (Compound)
Esmolol (Compound) resembles Pindolol (Compound) and Pindolol may lead to a major life threatening interaction when taken with Dolasetron
Esmolol (Compound) resembles Bisoprolol (Compound) and Bisoprolol may lead to a major life threatening interaction when taken with Dolasetron
Esmolol (Compound) resembles Acebutolol (Compound) and Acebutolol may lead to a major life threatening interaction when taken with Dolasetron
Esmolol (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is regulated by MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Dolasetron (Compound)
Esmolol (Compound) causes Oliguria (Side Effect) and Oliguria (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Dolasetron
Esmolol (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Hyoscyamine (Compound) and Hyoscyamine (Compound) resembles Dolasetron (Compound)
Esmolol (Compound) causes Peripheral ischaemia (Side Effect) and Peripheral ischaemia (Side Effect) is caused by Bisoprolol (Compound) and Bisoprolol may lead to a major life threatening interaction when taken with Dolasetron
Esmolol (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Dolasetron