DDInter297 DDInter1662
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Sertraline
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) SLC2A6
SLC2A6 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) resembles {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Sertraline
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Carbinoxamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sertraline (Compound)
Carbinoxamine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Sertraline (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Carbinoxamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Carbinoxamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by SLC2A6 (Gene) and SLC2A6 (Gene) is upregulated by Sertraline (Compound)
Carbinoxamine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Carbinoxamine (Compound) resembles Bisacodyl (Compound) and Bisacodyl (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sertraline (Compound)
Carbinoxamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with schizophrenia (Disease) and schizophrenia (Disease) is palliated by Sertraline (Compound)