DDInter1938 DDInter1001
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is a semisynthetic analogue of epothilone B. It has a lactone–lactam modification that minimizes susceptibility to esterase degradation.
Vincristine {u} (Compound) binds {v} (Gene) TUBB3
TUBB3 {u} (Gene) is bound by {v} (Compound) Ixabepilone
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB2A
TUBB2A {u} (Gene) is bound by {v} (Compound) Ixabepilone
Vincristine {u} (Compound) causes {v} (Side Effect) Dehydration
Dehydration {u} (Side Effect) is caused by {v} (Compound) Ixabepilone
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ixabepilone
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ixabepilone
Vincristine {u} (Compound) binds {v} (Gene) TUBB3
TUBB3 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Ixabepilone
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB2A
TUBB2A {u} (Gene) regulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) Ixabepilone
Vincristine {u} (Compound) binds {v} (Gene) TUBB2B
TUBB2B {u} (Gene) is bound by {v} (Compound) Eribulin
Eribulin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ixabepilone
Vincristine {u} (Compound) binds {v} (Gene) TUBB4B
TUBB4B {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ixabepilone
Vincristine {u} (Compound) binds {v} (Gene) TUBB
TUBB {u} (Gene) is bound by {v} (Compound) Colchicine
Colchicine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ixabepilone
Vincristine (Compound) binds TUBB3 (Gene) and TUBB3 (Gene) is bound by Ixabepilone (Compound)
Vincristine (Compound) binds TUBB2A (Gene) and Vincristine (Compound) upregulates TUBB2A (Gene) and TUBB2A (Gene) is bound by Ixabepilone (Compound)
Vincristine (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Vincristine (Compound) binds TUBB3 (Gene) and TUBB3 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Ixabepilone (Compound)
Vincristine (Compound) binds TUBB2A (Gene) and Vincristine (Compound) upregulates TUBB2A (Gene) and TUBB2A (Gene) regulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Ixabepilone (Compound)
Vincristine (Compound) binds TUBB2B (Gene) and TUBB2B (Gene) is bound by Eribulin (Compound) and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Vincristine (Compound) binds TUBB4B (Gene) and TUBB4B (Gene) is downregulated by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Vincristine (Compound) binds TUBB (Gene) and TUBB (Gene) is bound by Colchicine (Compound) and Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone