DDInter557 DDInter1224
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines. Minocycline was granted FDA approval on 30 June 1971.
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minocycline
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxycycline
Doxycycline {u} (Compound) resembles {v} (Compound) Minocycline
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Demeclocycline
Demeclocycline {u} (Compound) resembles {v} (Compound) Minocycline
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) SHB
SHB {u} (Gene) is regulated by {v} (Gene) VEGFA
VEGFA {u} (Gene) is bound by {v} (Compound) Minocycline
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) SPRED2
SPRED2 {u} (Gene) regulates {v} (Gene) VEGFA
VEGFA {u} (Gene) is bound by {v} (Compound) Minocycline
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxytetracycline
Oxytetracycline {u} (Compound) resembles {v} (Compound) Minocycline
Dihydroergotamine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) IL1B
IL1B {u} (Gene) is bound by {v} (Compound) Minocycline
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) SHB
SHB {u} (Gene) is downregulated by {v} (Compound) Piperacillin
Piperacillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minocycline
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Indapamide
Indapamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracycline
Tetracycline {u} (Compound) resembles {v} (Compound) Minocycline
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Minocycline
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound) and Doxycycline (Compound) resembles Minocycline (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Dihydroergotamine (Compound) downregulates SHB (Gene) and SHB (Gene) is regulated by VEGFA (Gene) and VEGFA (Gene) is bound by Minocycline (Compound)
Dihydroergotamine (Compound) downregulates SPRED2 (Gene) and SPRED2 (Gene) regulates VEGFA (Gene) and VEGFA (Gene) is bound by Minocycline (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline (Compound) resembles Minocycline (Compound)
Dihydroergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates IL1B (Gene) and IL1B (Gene) is bound by Minocycline (Compound)
Dihydroergotamine (Compound) downregulates SHB (Gene) and SHB (Gene) is downregulated by Piperacillin (Compound) and Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Minocycline
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Indapamide (Compound) and Indapamide may cause a minor interaction that can limit clinical effects when taken with Minocycline
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Minocycline (Compound)