DDInter1143 DDInter1055
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201]
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Meloxicam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) causes {v} (Side Effect) Bullous eruption
Bullous eruption {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) resembles {v} (Compound) Piroxicam
Piroxicam {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) resembles {v} (Compound) Nitazoxanide
Nitazoxanide {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) binds {v} (Gene) PGD
PGD {u} (Gene) regulates {v} (Gene) PLEKHM1
PLEKHM1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Meloxicam {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is upregulated by {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Meloxicam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Meloxicam (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Meloxicam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Meloxicam (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Meloxicam (Compound) causes Bullous eruption (Side Effect) and Bullous eruption (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Meloxicam (Compound) resembles Piroxicam (Compound) and Piroxicam (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Levofloxacin (Compound)
Meloxicam (Compound) resembles Nitazoxanide (Compound) and Nitazoxanide (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Levofloxacin (Compound)
Meloxicam (Compound) binds PGD (Gene) and PGD (Gene) regulates PLEKHM1 (Gene) and PLEKHM1 (Gene) is downregulated by Levofloxacin (Compound)
Meloxicam (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by PRKACA (Gene) and PRKACA (Gene) is downregulated by Levofloxacin (Compound)
Meloxicam (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is upregulated by chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)