DDInter336 DDInter72
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Aminolevulinic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Aminolevulinic acid
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) TARBP1
TARBP1 {u} (Gene) is downregulated by {v} (Compound) Aminolevulinic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) L-Glutamine
L-Glutamine {u} (Compound) resembles {v} (Compound) Aminolevulinic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Aminocaproic acid
Aminocaproic acid {u} (Compound) resembles {v} (Compound) Aminolevulinic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Dabrafenib
Dabrafenib {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Photosensitivity
Photosensitivity {u} (Side Effect) is caused by {v} (Compound) Hydroflumethiazide
Hydroflumethiazide {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Dabrafenib
Dabrafenib {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Ulcer
Ulcer {u} (Side Effect) is caused by {v} (Compound) Methyl aminolevulinate
Methyl aminolevulinate {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Aminolevulinic acid (Compound)
Celecoxib (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Aminolevulinic acid (Compound)
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is regulated by TARBP1 (Gene) and TARBP1 (Gene) is downregulated by Aminolevulinic acid (Compound)
Celecoxib (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by L-Glutamine (Compound) and L-Glutamine (Compound) resembles Aminolevulinic acid (Compound)
Celecoxib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Aminocaproic acid (Compound) and Aminocaproic acid (Compound) resembles Aminolevulinic acid (Compound)
Celecoxib (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Dabrafenib (Compound) and Dabrafenib may lead to a major life threatening interaction when taken with Aminolevulinic acid
Celecoxib (Compound) causes Photosensitivity (Side Effect) and Photosensitivity (Side Effect) is caused by Hydroflumethiazide (Compound) and Hydroflumethiazide may lead to a major life threatening interaction when taken with Aminolevulinic acid
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Dabrafenib (Compound) and Dabrafenib may lead to a major life threatening interaction when taken with Aminolevulinic acid
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Aminolevulinic acid
Celecoxib (Compound) causes Ulcer (Side Effect) and Ulcer (Side Effect) is caused by Methyl aminolevulinate (Compound) and Methyl aminolevulinate (Compound) resembles Aminolevulinic acid (Compound) and Methyl aminolevulinate may lead to a major life threatening interaction when taken with Aminolevulinic acid