DDInter336 DDInter790
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.
Celecoxib {u} (Compound) binds {v} (Gene) CA5A
CA5A {u} (Gene) is bound by {v} (Compound) Furosemide
Celecoxib {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Furosemide
Celecoxib {u} (Compound) binds {v} (Gene) CA5A
CA5A {u} (Gene) is bound by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Furosemide
Celecoxib {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Furosemide
Celecoxib {u} (Compound) palliates {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) upregulates {v} (Gene) PGD
PGD {u} (Gene) is bound by {v} (Compound) Furosemide
Celecoxib {u} (Compound) palliates {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is associated with {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Furosemide
Celecoxib {u} (Compound) palliates {v} (Disease) kidney cancer
kidney cancer {u} (Disease) downregulates {v} (Gene) CA4
CA4 {u} (Gene) is bound by {v} (Compound) Furosemide
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is regulated by {v} (Gene) SLC22A5
SLC22A5 {u} (Gene) is bound by {v} (Compound) Furosemide
Celecoxib (Compound) binds CA5A (Gene) and CA5A (Gene) is bound by Furosemide (Compound)
Celecoxib (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Furosemide (Compound)
Celecoxib (Compound) binds CA5A (Gene) and CA5A (Gene) is bound by Indapamide (Compound) and Indapamide (Compound) resembles Furosemide (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Furosemide (Compound)
Celecoxib (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Furosemide (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Furosemide (Compound)
Celecoxib (Compound) palliates hematologic cancer (Disease) and hematologic cancer (Disease) upregulates PGD (Gene) and PGD (Gene) is bound by Furosemide (Compound)
Celecoxib (Compound) palliates kidney cancer (Disease) and kidney cancer (Disease) is associated with CA9 (Gene) and CA9 (Gene) is bound by Furosemide (Compound)
Celecoxib (Compound) palliates kidney cancer (Disease) and kidney cancer (Disease) downregulates CA4 (Gene) and CA4 (Gene) is bound by Furosemide (Compound)
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is regulated by SLC22A5 (Gene) and SLC22A5 (Gene) is bound by Furosemide (Compound)