DDInter136 DDInter1651
Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products.[A251660,L42840] Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters.[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Atropine is a relatively inexpensive drug and
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system . Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
Atropine {u} (Compound) resembles {v} (Compound) Cyclopentolate
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Atropine {u} (Compound) binds {v} (Gene) CYP1A2
Atropine {u} (Compound) palliates {v} (Disease) Crohn's disease
Atropine {u} (Compound) is included by {v} (Pharmacologic Class) Cholinergic Muscarinic Antagonists
Atropine {u} (Compound) downregulates {v} (Gene) DLD
Atropine {u} (Compound) causes {v} (Side Effect) Supraventricular extrasystoles
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polythiazide
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Atropine (Compound) resembles Cyclopentolate (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Atropine (Compound) binds CYP1A2 (Gene)
Atropine (Compound) palliates Crohn's disease (Disease)
Atropine (Compound) is included by Cholinergic Muscarinic Antagonists (Pharmacologic Class)
Atropine (Compound) downregulates DLD (Gene)
Atropine (Compound) causes Supraventricular extrasystoles (Side Effect)
Atropine may cause a minor interaction that can limit clinical effects when taken with Polythiazide
Atropine may cause a minor interaction that can limit clinical effects when taken with Digoxin
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine