DDInter852 DDInter1016
Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Halofantrine {u} (Compound) resembles {v} (Compound) Lumefantrine
Halofantrine {u} (Compound) binds {v} (Gene) CYP2C8
Halofantrine {u} (Compound) upregulates {v} (Gene) HMOX1
Halofantrine {u} (Compound) downregulates {v} (Gene) CDC20
Halofantrine {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Halofantrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Halofantrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Halofantrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Halofantrine {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Halofantrine {u} may lead to a major life threatening interaction when taken with {v} Amiodarone
Halofantrine (Compound) resembles Lumefantrine (Compound)
Halofantrine (Compound) binds CYP2C8 (Gene)
Halofantrine (Compound) upregulates HMOX1 (Gene)
Halofantrine (Compound) downregulates CDC20 (Gene)
Halofantrine (Compound) causes Gastrointestinal pain (Side Effect)
Halofantrine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Halofantrine may lead to a major life threatening interaction when taken with Dasatinib
Halofantrine may lead to a major life threatening interaction when taken with Amiodarone