DDInter336 DDInter583
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia.[L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia. Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Celecoxib {u} (Compound) causes {v} (Side Effect) Abdominal pain upper
Abdominal pain upper {u} (Side Effect) is caused by {v} (Compound) Donepezil
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Doxazosin
Doxazosin {u} (Compound) resembles {v} (Compound) Donepezil
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Zafirlukast
Zafirlukast {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Celecoxib {u} (Compound) causes {v} (Side Effect) Abdominal pain upper
Abdominal pain upper {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Tetrabenazine {u} (Compound) resembles {v} (Compound) Donepezil
Celecoxib {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Zafirlukast
Zafirlukast {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Celecoxib {u} (Compound) causes {v} (Side Effect) Cholelithiasis
Cholelithiasis {u} (Side Effect) is caused by {v} (Compound) Doxazosin
Doxazosin {u} (Compound) resembles {v} (Compound) Donepezil
Celecoxib {u} (Compound) causes {v} (Side Effect) Cardiac failure congestive
Cardiac failure congestive {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tetrabenazine
Tetrabenazine {u} (Compound) resembles {v} (Compound) Donepezil
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Celecoxib (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Donepezil (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Doxazosin (Compound) and Doxazosin (Compound) resembles Donepezil (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zafirlukast (Compound) and Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Donepezil
Celecoxib (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Tetrabenazine (Compound) and Tetrabenazine (Compound) resembles Donepezil (Compound)
Celecoxib (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Zafirlukast (Compound) and Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Donepezil
Celecoxib (Compound) causes Cholelithiasis (Side Effect) and Cholelithiasis (Side Effect) is caused by Doxazosin (Compound) and Doxazosin (Compound) resembles Donepezil (Compound)
Celecoxib (Compound) causes Cardiac failure congestive (Side Effect) and Cardiac failure congestive (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may cause a minor interaction that can limit clinical effects when taken with Donepezil
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound) and Tetrabenazine (Compound) resembles Donepezil (Compound)