DDInter702 DDInter875
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and self-assembled into VLPs.
Etoposide {u} (Compound) resembles {v} (Compound) Podofilox
Etoposide {u} (Compound) treats {v} (Disease) urinary bladder cancer
Etoposide {u} (Compound) binds {v} (Gene) GSTT1
Etoposide {u} (Compound) upregulates {v} (Gene) COL11A1
Etoposide {u} (Compound) is included by {v} (Pharmacologic Class) Topoisomerase Inhibitors
Etoposide {u} (Compound) downregulates {v} (Gene) AURKB
Etoposide {u} (Compound) causes {v} (Side Effect) Necrolysis epidermal
Etoposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Etoposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alefacept
Etoposide (Compound) resembles Podofilox (Compound)
Etoposide (Compound) treats urinary bladder cancer (Disease)
Etoposide (Compound) binds GSTT1 (Gene)
Etoposide (Compound) upregulates COL11A1 (Gene)
Etoposide (Compound) is included by Topoisomerase Inhibitors (Pharmacologic Class)
Etoposide (Compound) downregulates AURKB (Gene)
Etoposide (Compound) causes Necrolysis epidermal (Side Effect)
Etoposide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Etoposide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Alefacept