DDInter781 DDInter1497
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage forms and those products formulated for preparation of solution prior to ingestion.
Fosinopril {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Potassium chloride
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Fosinopril {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Calcium chloride
Calcium chloride {u} (Compound) resembles {v} (Compound) Potassium chloride
Fosinopril {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Meclofenamic acid
Meclofenamic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Potassium chloride
Fosinopril {u} (Compound) causes {v} (Side Effect) Pregnancy
Pregnancy {u} (Side Effect) is caused by {v} (Compound) Glycopyrronium
Glycopyrronium {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Fosinopril {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Potassium chloride
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) causes {v} (Side Effect) Fluid overload
Fluid overload {u} (Side Effect) is caused by {v} (Compound) Potassium chloride
Fosinopril {u} (Compound) causes {v} (Side Effect) Cardiac arrest
Cardiac arrest {u} (Side Effect) is caused by {v} (Compound) Lisinopril
Lisinopril {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) SLC12A2
SLC12A2 {u} (Gene) is bound by {v} (Compound) Potassium chloride
Fosinopril {u} (Compound) resembles {v} (Compound) Cilazapril
Cilazapril {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Potassium chloride
Fosinopril (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril may lead to a major life threatening interaction when taken with Potassium chloride
Fosinopril (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Calcium chloride (Compound) and Calcium chloride (Compound) resembles Potassium chloride (Compound)
Fosinopril (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Meclofenamic acid (Compound) and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Potassium chloride
Fosinopril (Compound) causes Pregnancy (Side Effect) and Pregnancy (Side Effect) is caused by Glycopyrronium (Compound) and Glycopyrronium may lead to a major life threatening interaction when taken with Potassium chloride
Fosinopril (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Indomethacin (Compound) and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Potassium chloride
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) causes Fluid overload (Side Effect) and Fluid overload (Side Effect) is caused by Potassium chloride (Compound)
Fosinopril (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Lisinopril (Compound) and Lisinopril may lead to a major life threatening interaction when taken with Potassium chloride
Fosinopril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with SLC12A2 (Gene) and SLC12A2 (Gene) is bound by Potassium chloride (Compound)
Fosinopril (Compound) resembles Cilazapril (Compound) and Cilazapril (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)