DDInter1476 DDInter1417
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3†,5†-adenosine monophosphate (c-
Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects. This binding characteristic of penbutolol is being investigated for its implications in Antidepressant Therapy. Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity.
Pirbuterol {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) resembles {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) resembles {v} (Compound) Epinephrine
Epinephrine {u} may lead to a major life threatening interaction when taken with {v} Penbutolol
Pirbuterol {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) resembles {v} (Compound) Timolol
Timolol {u} (Compound) resembles {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) resembles {v} (Compound) Nadolol
Nadolol {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) resembles {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Timolol
Timolol {u} (Compound) resembles {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Timolol
Timolol {u} (Compound) resembles {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) resembles {v} (Compound) Epinephrine
Epinephrine {u} may lead to a major life threatening interaction when taken with {v} Timolol
Timolol {u} (Compound) resembles {v} (Compound) Penbutolol
Pirbuterol {u} (Compound) resembles {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Salbutamol
Salbutamol {u} may lead to a major life threatening interaction when taken with {v} Penbutolol
Pirbuterol (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) resembles Penbutolol (Compound)
Pirbuterol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Penbutolol (Compound)
Pirbuterol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Penbutolol (Compound)
Pirbuterol (Compound) resembles Epinephrine (Compound) and Epinephrine may lead to a major life threatening interaction when taken with Penbutolol
Pirbuterol (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) resembles Timolol (Compound) and Timolol (Compound) resembles Penbutolol (Compound)
Pirbuterol (Compound) resembles Nadolol (Compound) and Nadolol (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) resembles Penbutolol (Compound)
Pirbuterol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Timolol (Compound) and Timolol (Compound) resembles Penbutolol (Compound)
Pirbuterol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Timolol (Compound) and Timolol (Compound) resembles Penbutolol (Compound)
Pirbuterol (Compound) resembles Epinephrine (Compound) and Epinephrine may lead to a major life threatening interaction when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Pirbuterol (Compound) resembles Terbutaline (Compound) and Terbutaline (Compound) resembles Salbutamol (Compound) and Salbutamol may lead to a major life threatening interaction when taken with Penbutolol