DDInter676 DDInter178
Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome. It can also be found in quadruple regimens for the treatment of _H. pylori_ infections along with other antibiotics including,, and, for example.[A177271, F4498] Its efficacy is considered similar to other medications within the PPI class including,,,, and. Esomeprazole is the s-isomer of, which is a racemate of the S- and R-enantiomer. Esomeprazole has been shown to inhibit acid secretion to a similar extent as, without any significant differences between the two compounds _in vitro_. Esome
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Esomeprazole {u} (Compound) resembles {v} (Compound) Lansoprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Esomeprazole {u} (Compound) treats {v} (Disease) Barrett's esophagus
Esomeprazole {u} (Compound) binds {v} (Gene) ATP4A
Esomeprazole {u} (Compound) upregulates {v} (Gene) TIPARP
Esomeprazole {u} (Compound) palliates {v} (Disease) prostate cancer
Esomeprazole {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 2C19 Inhibitors
Esomeprazole {u} (Compound) downregulates {v} (Gene) TRAPPC3
Esomeprazole {u} (Compound) causes {v} (Side Effect) Muscle spasms
Esomeprazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Choline salicylate
Esomeprazole (Compound) resembles Lansoprazole (Compound)
Esomeprazole (Compound) resembles Omeprazole (Compound)
Esomeprazole (Compound) treats Barrett's esophagus (Disease)
Esomeprazole (Compound) binds ATP4A (Gene)
Esomeprazole (Compound) upregulates TIPARP (Gene)
Esomeprazole (Compound) palliates prostate cancer (Disease)
Esomeprazole (Compound) is included by Cytochrome P450 2C19 Inhibitors (Pharmacologic Class)
Esomeprazole (Compound) downregulates TRAPPC3 (Gene)
Esomeprazole (Compound) causes Muscle spasms (Side Effect)
Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate