DDInter1042 DDInter1646
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Saxagliptin {u} (Compound) resembles {v} (Compound) Vildagliptin
Saxagliptin {u} (Compound) binds {v} (Gene) DPP8
Saxagliptin {u} (Compound) causes {v} (Side Effect) Upper respiratory tract infection
Saxagliptin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midostaurin
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroflumethiazide
Saxagliptin {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Saxagliptin (Compound) resembles Vildagliptin (Compound)
Saxagliptin (Compound) binds DPP8 (Gene)
Saxagliptin (Compound) causes Upper respiratory tract infection (Side Effect)
Saxagliptin may cause a minor interaction that can limit clinical effects when taken with Modafinil
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide
Saxagliptin may lead to a major life threatening interaction when taken with Bexarotene