DDInter1520 DDInter1376
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Primaquine {u} (Compound) resembles {v} (Compound) Chloroquine
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Primaquine {u} (Compound) binds {v} (Gene) SENP8
Primaquine {u} (Compound) downregulates {v} (Gene) PSMB8
Primaquine {u} (Compound) causes {v} (Side Effect) Nausea
Primaquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Romidepsin
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Primaquine (Compound) resembles Chloroquine (Compound)
Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Primaquine (Compound) binds SENP8 (Gene)
Primaquine (Compound) downregulates PSMB8 (Gene)
Primaquine (Compound) causes Nausea (Side Effect)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Primaquine may lead to a major life threatening interaction when taken with Prilocaine