DDInter162 DDInter1878
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Baclofen {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Baclofen {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Tripelennamine
Baclofen {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Benzphetamine
Benzphetamine {u} (Compound) resembles {v} (Compound) Tripelennamine
Baclofen {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Baclofen {u} (Compound) causes {v} (Side Effect) Drug withdrawal syndrome
Drug withdrawal syndrome {u} (Side Effect) is caused by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Tripelennamine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bepridil
Bepridil {u} (Compound) resembles {v} (Compound) Tripelennamine
Baclofen {u} (Compound) binds {v} (Gene) GABBR1
GABBR1 {u} (Gene) is bound by {v} (Compound) Vigabatrin
Vigabatrin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Baclofen (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Baclofen (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Tripelennamine (Compound)
Baclofen (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Benzphetamine (Compound) and Benzphetamine (Compound) resembles Tripelennamine (Compound)
Baclofen (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Baclofen (Compound) causes Drug withdrawal syndrome (Side Effect) and Drug withdrawal syndrome (Side Effect) is caused by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Tripelennamine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Bepridil and Bepridil (Compound) resembles Tripelennamine (Compound)
Baclofen (Compound) binds GABBR1 (Gene) and GABBR1 (Gene) is bound by Vigabatrin (Compound) and Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine