DDInter641 DDInter815
Enflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market.[L13646,L13649] Unlike its other inhalational anesthetic counterparts including [isoflurane] and [halothane], enflurane is known to induce seizure activity. In addition, it is known to cause increased cardio depressant effects when compared to other inhaled anesthetics.
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams. This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.
Enflurane {u} (Compound) causes {v} (Side Effect) Respiratory depression
Respiratory depression {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Enflurane {u} (Compound) causes {v} (Side Effect) Respiratory depression
Respiratory depression {u} (Side Effect) is caused by {v} (Compound) Tobramycin
Tobramycin {u} (Compound) resembles {v} (Compound) Gentamicin
Enflurane {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gentamicin
Enflurane {u} (Compound) resembles {v} (Compound) Isoflurane
Isoflurane {u} (Compound) causes {v} (Side Effect) Hallucination
Hallucination {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Enflurane {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Piperacillin
Piperacillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Enflurane {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Cefotetan
Cefotetan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Enflurane {u} (Compound) binds {v} (Gene) KCNN4
KCNN4 {u} (Gene) is regulated by {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Gentamicin
Enflurane {u} (Compound) binds {v} (Gene) ATP5D
ATP5D {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Methoxyflurane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Enflurane {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Gentamicin
Enflurane {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Oxaliplatin
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Enflurane (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Gentamicin (Compound)
Enflurane (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Tobramycin (Compound) and Tobramycin (Compound) resembles Gentamicin (Compound)
Enflurane (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Gentamicin
Enflurane (Compound) resembles Isoflurane (Compound) and Isoflurane (Compound) causes Hallucination (Side Effect) and Hallucination (Side Effect) is caused by Gentamicin (Compound)
Enflurane (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Piperacillin (Compound) and Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Enflurane (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Cefotetan (Compound) and Cefotetan may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Enflurane (Compound) binds KCNN4 (Gene) and KCNN4 (Gene) is regulated by STUB1 (Gene) and STUB1 (Gene) is downregulated by Gentamicin (Compound)
Enflurane (Compound) binds ATP5D (Gene) and ATP5D (Gene) is bound by Methoxyflurane (Compound) and Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Enflurane (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Gentamicin (Compound)
Enflurane (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Oxaliplatin (Compound) and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin