DDInter1453 DDInter1476
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Phenylephrine {u} (Compound) resembles {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} (Compound) resembles {v} (Compound) Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} (Compound) causes {v} (Side Effect) Ischaemia
Ischaemia {u} (Side Effect) is caused by {v} (Compound) Pirbuterol
Phenylephrine {u} (Compound) resembles {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nadolol
Nadolol {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} (Compound) resembles {v} (Compound) Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} (Compound) causes {v} (Side Effect) Ischaemia
Ischaemia {u} (Side Effect) is caused by {v} (Compound) Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Pirbuterol
Phenylephrine (Compound) resembles Terbutaline (Compound) and Terbutaline (Compound) resembles Pirbuterol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol (Compound) resembles Pirbuterol (Compound)
Phenylephrine (Compound) resembles Epinephrine (Compound) and Epinephrine (Compound) resembles Pirbuterol (Compound)
Phenylephrine (Compound) causes Ischaemia (Side Effect) and Ischaemia (Side Effect) is caused by Pirbuterol (Compound)
Phenylephrine (Compound) resembles Terbutaline (Compound) and Terbutaline (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) resembles Pirbuterol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) resembles Pirbuterol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) resembles Pirbuterol (Compound)
Phenylephrine (Compound) resembles Epinephrine (Compound) and Epinephrine (Compound) resembles Terbutaline (Compound) and Terbutaline (Compound) resembles Pirbuterol (Compound)
Phenylephrine (Compound) causes Ischaemia (Side Effect) and Ischaemia (Side Effect) is caused by Epinephrine (Compound) and Epinephrine (Compound) resembles Pirbuterol (Compound)
Phenylephrine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Terbutaline (Compound) and Terbutaline (Compound) resembles Pirbuterol (Compound)