DDInter1088 DDInter1180
Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxylate] and [haloperidol]. Due to pharmacological properties, loperamide has been misused and abused to self-manage opioid withdrawal symptoms and to induce euphoria.[A251610, A251625] However, loperamide is associated with a risk for experiencing a range of adverse effects, often life-threatening, if taking for non-therapeutic reasons or at doses higher than the recommended dose.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Loperamide {u} (Compound) resembles {v} (Compound) Methadyl Acetate
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextropropoxyphene
Loperamide {u} (Compound) resembles {v} (Compound) Clofedanol
Loperamide {u} (Compound) binds {v} (Gene) CYP3A4
Loperamide {u} (Compound) upregulates {v} (Gene) SQLE
Loperamide {u} (Compound) is included by {v} (Pharmacologic Class) Opioid Agonists
Loperamide {u} (Compound) downregulates {v} (Gene) MRPL12
Loperamide {u} (Compound) causes {v} (Side Effect) Nausea
Loperamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cholestyramine
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ivacaftor
Loperamide (Compound) resembles Methadyl Acetate (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene
Loperamide (Compound) resembles Clofedanol (Compound)
Loperamide (Compound) binds CYP3A4 (Gene)
Loperamide (Compound) upregulates SQLE (Gene)
Loperamide (Compound) is included by Opioid Agonists (Pharmacologic Class)
Loperamide (Compound) downregulates MRPL12 (Gene)
Loperamide (Compound) causes Nausea (Side Effect)
Loperamide may cause a minor interaction that can limit clinical effects when taken with Cholestyramine
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor