DDInter1140 DDInter1243
Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortality; 90% of deaths from malaria occur in Africa. Individuals at the highest risk for malaria are those in disease naïve populations, children under age 5, refugees in Central and Eastern Africa, nonimmune civilian and military travelers, pregnant women, and immigrants traveling to their place of origin. Mefloquine, commonly known as Lariam, is an antimalarial drug used for the prevention and treatment of malaria caused by infection with Plasmodium vivax and Plasmodium falciparum. The drug was initially discovered by the Walter Reed Army Institute of Research (WRAIR) during a malaria drug discovery program between 196
An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may lead to a major life threatening interaction when taken with {v} Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Propericiazine
Propericiazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may lead to a major life threatening interaction when taken with {v} Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Promethazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may lead to a major life threatening interaction when taken with {v} Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Acepromazine
Acepromazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimipramine
Trimipramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Methdilazine {u} (Compound) resembles {v} (Compound) Moricizine
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Moricizine (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Moricizine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Propericiazine (Compound) and Propericiazine (Compound) resembles Moricizine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine (Compound) resembles Moricizine (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine (Compound) resembles Moricizine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Moricizine (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Acepromazine (Compound) and Acepromazine (Compound) resembles Moricizine (Compound)
Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Methotrimeprazine (Compound) and Methotrimeprazine (Compound) resembles Moricizine (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Methotrimeprazine (Compound) and Methotrimeprazine (Compound) resembles Moricizine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Methdilazine (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Moricizine (Compound)