DDInter1866 DDInter927
A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Inotuzumab ozogamicin is an antibody-drug conjugate using linker and cytotoxic drug technology similar to that developed for the ground-breaking treatment Mylotarg (), which was approved by the US FDA in 2000 for the treatment of acute myeloid leukaemia. Inotuzumab ozogamicin consists of a recombinant humanised IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide, which is a potent DNA-binding cytotoxic agent . Developed by Pfizer and UCB, inotuzumab ozogamicin was granted approval by EU in June 2017 followed by FDA on August 17th, 2017 for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). ALL is a rapidly progressing cancer of the bone marrow that is associated with high mortality rates and low therapeutic response from standard chemotherapies in relasping conditions. In a randomized trial, inotuzumab ozogamicin displayed higher percentages of patients undergoing longer periods of complete remission with no evidence of disease in comparison to patients receiving alternative chemotherapy .
Trifluoperazine {u} (Compound) resembles {v} (Compound) Clozapine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Zuclopenthixol
Trifluoperazine {u} (Compound) binds {v} (Gene) ADRA1A
Trifluoperazine {u} (Compound) upregulates {v} (Gene) SREBF2
Trifluoperazine {u} (Compound) palliates {v} (Disease) schizophrenia
Trifluoperazine {u} (Compound) is included by {v} (Pharmacologic Class) Phenothiazines
Trifluoperazine {u} (Compound) downregulates {v} (Gene) PSMD2
Trifluoperazine {u} (Compound) causes {v} (Side Effect) Convulsion
Trifluoperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magaldrate
Trifluoperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Trifluoperazine (Compound) resembles Clozapine (Compound)
Trifluoperazine (Compound) resembles Zuclopenthixol (Compound)
Trifluoperazine (Compound) binds ADRA1A (Gene)
Trifluoperazine (Compound) upregulates SREBF2 (Gene)
Trifluoperazine (Compound) palliates schizophrenia (Disease)
Trifluoperazine (Compound) is included by Phenothiazines (Pharmacologic Class)
Trifluoperazine (Compound) downregulates PSMD2 (Gene)
Trifluoperazine (Compound) causes Convulsion (Side Effect)
Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate