DDInter743 DDInter1666
Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late 1980s . Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises [A175579, A175582, A175654]. Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in the public in 1998 , continues to see millions of prescriptions written for it internationally. Although the medication has historically been most popularly recognized as Pfizer's brand name Viagra, sildenafil is currently available generically and even as a non-prescription over the counter medication in some countries .
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Sildenafil
Fluconazole {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Sildenafil
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Udenafil
Udenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Vardenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Fluconazole {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Vardenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Vardenafil {u} (Compound) upregulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is bound by {v} (Compound) Sildenafil
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Vardenafil {u} (Compound) binds {v} (Gene) PDE6H
PDE6H {u} (Gene) is bound by {v} (Compound) Sildenafil
Fluconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palonosetron
Palonosetron {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil (Compound) resembles Sildenafil (Compound)
Fluconazole (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Sildenafil (Compound)
Fluconazole (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sildenafil (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil (Compound) resembles Udenafil (Compound) and Udenafil (Compound) resembles Sildenafil (Compound)
Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Vardenafil (Compound) and Vardenafil (Compound) resembles Sildenafil (Compound)
Fluconazole (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vardenafil (Compound) and Vardenafil (Compound) resembles Sildenafil (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is bound by Sildenafil (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil (Compound) binds PDE6H (Gene) and PDE6H (Gene) is bound by Sildenafil (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil (Compound) resembles Sildenafil (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil and Vardenafil (Compound) resembles Sildenafil (Compound)