DDInter591 DDInter1376
A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Doxapram {u} (Compound) resembles {v} (Compound) Loperamide
Doxapram {u} (Compound) resembles {v} (Compound) Minaprine
Doxapram {u} (Compound) binds {v} (Gene) KCNK3
Doxapram {u} (Compound) upregulates {v} (Gene) INPP1
Doxapram {u} (Compound) is included by {v} (Pharmacologic Class) Increased Medullary Respiratory Drive
Doxapram {u} (Compound) downregulates {v} (Gene) TRIB1
Doxapram {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Doxapram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dobutamine
Doxapram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylpropanolamine
Doxapram {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Doxapram (Compound) resembles Loperamide (Compound)
Doxapram (Compound) resembles Minaprine (Compound)
Doxapram (Compound) binds KCNK3 (Gene)
Doxapram (Compound) upregulates INPP1 (Gene)
Doxapram (Compound) is included by Increased Medullary Respiratory Drive (Pharmacologic Class)
Doxapram (Compound) downregulates TRIB1 (Gene)
Doxapram (Compound) causes Hyperhidrosis (Side Effect)
Doxapram may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine
Doxapram may cause a moderate interaction that could exacerbate diseases when taken with Phenylpropanolamine
Doxapram may lead to a major life threatening interaction when taken with Methylene blue