DDInter336 DDInter1832
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Tolterodine
Celecoxib {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Tolterodine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Brompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Fesoterodine
Fesoterodine {u} (Compound) resembles {v} (Compound) Tolterodine
Celecoxib {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Fesoterodine
Fesoterodine {u} (Compound) resembles {v} (Compound) Tolterodine
Celecoxib {u} (Compound) causes {v} (Side Effect) Influenza-like symptoms
Influenza-like symptoms {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Celecoxib {u} (Compound) causes {v} (Side Effect) Influenza like illness
Influenza like illness {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Terbinafine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Celecoxib {u} (Compound) causes {v} (Side Effect) Influenza-like symptoms
Influenza-like symptoms {u} (Side Effect) is caused by {v} (Compound) Tiotropium
Tiotropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Celecoxib {u} (Compound) causes {v} (Side Effect) Gastrooesophageal reflux disease
Gastrooesophageal reflux disease {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Tolterodine (Compound)
Celecoxib (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Tolterodine (Compound)
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Brompheniramine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound) and Fesoterodine (Compound) resembles Tolterodine (Compound)
Celecoxib (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Fesoterodine (Compound) and Fesoterodine (Compound) resembles Tolterodine (Compound)
Celecoxib (Compound) causes Influenza-like symptoms (Side Effect) and Influenza-like symptoms (Side Effect) is caused by Bupropion (Compound) and Bupropion may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Celecoxib (Compound) causes Influenza like illness (Side Effect) and Influenza like illness (Side Effect) is caused by Terbinafine (Compound) and Terbinafine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Celecoxib (Compound) causes Influenza-like symptoms (Side Effect) and Influenza-like symptoms (Side Effect) is caused by Tiotropium (Compound) and Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Celecoxib (Compound) causes Gastrooesophageal reflux disease (Side Effect) and Gastrooesophageal reflux disease (Side Effect) is caused by Atropine (Compound) and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine