DDInter1758 DDInter381
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Telithromycin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Cinacalcet
Telithromycin {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Cinacalcet
Telithromycin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin {u} (Compound) causes {v} (Side Effect) Arthralgia
Arthralgia {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Cinacalcet
Telithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin {u} may lead to a major life threatening interaction when taken with {v} Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} may lead to a major life threatening interaction when taken with {v} Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Telithromycin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cinacalcet (Compound)
Telithromycin (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Cinacalcet (Compound)
Telithromycin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Telithromycin (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Telithromycin (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Telithromycin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Telithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Cinacalcet (Compound)
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) resembles Naftifine (Compound) and Naftifine (Compound) resembles Cinacalcet (Compound)
Telithromycin may lead to a major life threatening interaction when taken with Toremifene and Toremifene (Compound) resembles Naftifine (Compound) and Naftifine (Compound) resembles Cinacalcet (Compound)
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine (Compound) resembles Cinacalcet (Compound)