DDInter1834 DDInter149
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Azatadine
Topiramate {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Ketotifen
Ketotifen {u} (Compound) resembles {v} (Compound) Azatadine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Azatadine
Topiramate {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Topiramate {u} (Compound) causes {v} (Side Effect) Dry eye
Dry eye {u} (Side Effect) is caused by {v} (Compound) Zaleplon
Zaleplon {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Topiramate {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Azatadine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Mianserin
Mianserin {u} (Compound) resembles {v} (Compound) Azatadine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Topiramate {u} (Compound) causes {v} (Side Effect) Dry eye
Dry eye {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Azatadine (Compound)
Topiramate (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ketotifen (Compound) and Ketotifen (Compound) resembles Azatadine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Azatadine (Compound)
Topiramate (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Topiramate (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Zaleplon (Compound) and Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Topiramate (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Azatadine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mianserin (Compound) and Mianserin (Compound) resembles Azatadine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Topiramate (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azatadine (Compound) and Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine