DDInter77 DDInter1016
Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major depression. Amisulpride predominantly works in the limbic system, which explains its relatively lower risk of extrapyramidal adverse effects compared to other atypical antipsychotic agents.[A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and chronic schizophrenic disorders, as well as secondary negative symptoms in mental health disorders such as affective disorders, depressive mood, and mental retardation. Amisulpride is also used as an antiemetic agent. In the US, the intravenous formulation of amisulpride is used to treat and prevent postoperative nausea
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Amisulpride {u} (Compound) resembles {v} (Compound) Alizapride
Amisulpride {u} (Compound) binds {v} (Gene) HTR7
Amisulpride {u} (Compound) upregulates {v} (Gene) RGS2
Amisulpride {u} (Compound) causes {v} (Side Effect) Urticaria
Amisulpride {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Amisulpride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin Immune Fab (Ovine)
Amisulpride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium sulfate
Amisulpride {u} may lead to a major life threatening interaction when taken with {v} Ribociclib
Amisulpride {u} may lead to a major life threatening interaction when taken with {v} Promethazine
Amisulpride {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Amisulpride (Compound) resembles Alizapride (Compound)
Amisulpride (Compound) binds HTR7 (Gene)
Amisulpride (Compound) upregulates RGS2 (Gene)
Amisulpride (Compound) causes Urticaria (Side Effect)
Amisulpride may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Amisulpride may cause a moderate interaction that could exacerbate diseases when taken with Digoxin Immune Fab (Ovine)
Amisulpride may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Amisulpride may lead to a major life threatening interaction when taken with Ribociclib
Amisulpride may lead to a major life threatening interaction when taken with Promethazine
Amisulpride (Compound) resembles Metoclopramide (Compound) and Amisulpride may lead to a major life threatening interaction when taken with Metoclopramide