DDInter1174 DDInter1956
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) downregulates {v} (Gene) ZW10
ZW10 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) regulates {v} (Gene) NUP85
NUP85 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Methotrexate {u} (Compound) downregulates {v} (Gene) ZW10
ZW10 {u} (Gene) is regulated by {v} (Gene) ANO10
ANO10 {u} (Gene) is upregulated by {v} (Compound) Zalcitabine
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Zalcitabine (Compound)
Methotrexate (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Methotrexate (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Zalcitabine (Compound)
Methotrexate (Compound) downregulates ZW10 (Gene) and ZW10 (Gene) is downregulated by Zalcitabine (Compound)
Methotrexate (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Zalcitabine (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Methotrexate (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Methotrexate (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) regulates NUP85 (Gene) and NUP85 (Gene) is downregulated by Zalcitabine (Compound)
Methotrexate (Compound) downregulates ZW10 (Gene) and ZW10 (Gene) is regulated by ANO10 (Gene) and ANO10 (Gene) is upregulated by Zalcitabine (Compound)