DDInter458 DDInter781
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Chills
Chills {u} (Side Effect) is caused by {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is upregulated by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) regulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is upregulated by {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) treats {v} (Disease) focal segmental glomerulosclerosis
focal segmental glomerulosclerosis {u} (Disease) resembles {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Fosinopril
Cyclosporine {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Fosinopril
Cyclosporine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Fosinopril (Compound)
Cyclosporine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Cyclosporine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Cilazapril (Compound) and Cilazapril (Compound) resembles Fosinopril (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is upregulated by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cilazapril (Compound) and Cilazapril (Compound) resembles Fosinopril (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) regulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Fosinopril (Compound)
Cyclosporine (Compound) treats focal segmental glomerulosclerosis (Disease) and focal segmental glomerulosclerosis (Disease) resembles hypertension (Disease) and hypertension (Disease) is treated by Fosinopril (Compound)
Cyclosporine (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Fosinopril (Compound)