DDInter458 DDInter1348
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical intervention is required. Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes. It was approved by the FDA for use in combination with a reduced-calorie diet in 1999. This drug is a generally well-tolerated and effective weight-loss aid and is now available in both over-the-counter and prescription preparations, depending on the dosage quantity.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) causes {v} (Side Effect) Multiple fractures
Multiple fractures {u} (Side Effect) is caused by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is associated with {v} (Disease) type 2 diabetes mellitus
type 2 diabetes mellitus {u} (Disease) is treated by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is regulated by {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is associated with {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) regulates {v} (Gene) FASN
FASN {u} (Gene) is bound by {v} (Compound) Orlistat
Cyclosporine {u} (Compound) causes {v} (Side Effect) Multiple fractures
Multiple fractures {u} (Side Effect) is caused by {v} (Compound) Dapagliflozin
Dapagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orlistat
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Orlistat (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Orlistat (Compound)
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Orlistat (Compound)
Cyclosporine (Compound) causes Multiple fractures (Side Effect) and Multiple fractures (Side Effect) is caused by Orlistat (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is associated with type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Orlistat (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is regulated by ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Orlistat (Compound)
Cyclosporine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) interacts with HMGCR (Gene) and INSIG1 (Gene) is regulated by HMGCR (Gene) and HMGCR (Gene) is upregulated by Orlistat (Compound)
Cyclosporine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is associated with obesity (Disease) and obesity (Disease) is treated by Orlistat (Compound)
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) regulates FASN (Gene) and FASN (Gene) is bound by Orlistat (Compound)
Cyclosporine (Compound) causes Multiple fractures (Side Effect) and Multiple fractures (Side Effect) is caused by Dapagliflozin (Compound) and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Orlistat