DDInter1826 DDInter1947
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase inhibitors. A recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier studies). Further brain tumor trials are planned using combinations of vorinostat with other drugs.
Tolazamide {u} (Compound) upregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is downregulated by {v} (Compound) Vorinostat
Tolazamide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Vorinostat
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Tolazamide {u} (Compound) upregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is regulated by {v} (Gene) HDAC6
HDAC6 {u} (Gene) is bound by {v} (Compound) Vorinostat
Tolazamide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Tolazamide {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Azelaic Acid
Azelaic Acid {u} (Compound) resembles {v} (Compound) Vorinostat
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Vorinostat
Tolazamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Tolazamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Canagliflozin
Canagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} (Compound) downregulates {v} (Gene) MIF
MIF {u} (Gene) is downregulated by {v} (Compound) Vorinostat
Tolazamide (Compound) upregulates JADE2 (Gene) and JADE2 (Gene) is downregulated by Vorinostat (Compound)
Tolazamide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Vorinostat (Compound)
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Tolazamide (Compound) upregulates JADE2 (Gene) and JADE2 (Gene) is regulated by HDAC6 (Gene) and HDAC6 (Gene) is bound by Vorinostat (Compound)
Tolazamide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Tolazamide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Azelaic Acid (Compound) and Azelaic Acid (Compound) resembles Vorinostat (Compound)
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Vorinostat (Compound)
Tolazamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Tolazamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Canagliflozin (Compound) and Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide (Compound) downregulates MIF (Gene) and MIF (Gene) is downregulated by Vorinostat (Compound)