DDInter268 DDInter1120
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Calcitriol {u} (Compound) causes {v} (Side Effect) Poisoning
Poisoning {u} (Side Effect) is caused by {v} (Compound) Magnesium sulfate
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol {u} (Compound) causes {v} (Side Effect) Poisoning
Poisoning {u} (Side Effect) is caused by {v} (Compound) Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium gluconate
Magnesium gluconate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Paricalcitol {u} (Compound) causes {v} (Side Effect) Depressed level of consciousness
Depressed level of consciousness {u} (Side Effect) is caused by {v} (Compound) Magnesium sulfate
Calcitriol {u} (Compound) upregulates {v} (Gene) RNF167
RNF167 {u} (Gene) is regulated by {v} (Gene) CACNA1C
CACNA1C {u} (Gene) is bound by {v} (Compound) Magnesium sulfate
Calcitriol {u} (Compound) upregulates {v} (Gene) RNF167
RNF167 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Gatifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may lead to a major life threatening interaction when taken with {v} Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Ergocalciferol {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium sulfate
Calcitriol (Compound) causes Poisoning (Side Effect) and Poisoning (Side Effect) is caused by Magnesium sulfate (Compound)
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcitriol (Compound) resembles Paricalcitol (Compound) and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcitriol (Compound) causes Poisoning (Side Effect) and Poisoning (Side Effect) is caused by Paricalcitol (Compound) and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate and Magnesium gluconate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcitriol (Compound) resembles Paricalcitol (Compound) and Paricalcitol (Compound) causes Depressed level of consciousness (Side Effect) and Depressed level of consciousness (Side Effect) is caused by Magnesium sulfate (Compound)
Calcitriol (Compound) upregulates RNF167 (Gene) and RNF167 (Gene) is regulated by CACNA1C (Gene) and CACNA1C (Gene) is bound by Magnesium sulfate (Compound)
Calcitriol (Compound) upregulates RNF167 (Gene) and RNF167 (Gene) is downregulated by Gatifloxacin (Compound) and Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalcitol and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate
Calcitriol (Compound) resembles Ergocalciferol (Compound) and Ergocalciferol (Compound) resembles Cholecalciferol (Compound) and Ergocalciferol may lead to a major life threatening interaction when taken with Cholecalciferol and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate