DDInter1834 DDInter1164
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. Another well-known benefit of this drug is modest weight loss, making it an effective choice for obese patients type II diabetes. Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the US in 1995.
Topiramate {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Metformin
Topiramate {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Memantine
Memantine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metformin
Topiramate {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Topiramate {u} (Compound) causes {v} (Side Effect) Abdominal pain upper
Abdominal pain upper {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Topiramate {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Midodrine
Midodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metformin
Topiramate {u} (Compound) binds {v} (Gene) GRIK2
GRIK2 {u} (Gene) is downregulated by {v} (Disease) polycystic ovary syndrome
polycystic ovary syndrome {u} (Disease) is treated by {v} (Compound) Metformin
Topiramate {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) resembles {v} (Disease) polycystic ovary syndrome
polycystic ovary syndrome {u} (Disease) is treated by {v} (Compound) Metformin
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is associated with {v} (Disease) type 2 diabetes mellitus
type 2 diabetes mellitus {u} (Disease) is treated by {v} (Compound) Metformin
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) NDUFS8
NDUFS8 {u} (Gene) is bound by {v} (Compound) Metformin
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Progesterone
Progesterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Topiramate (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metformin (Compound)
Topiramate (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Memantine (Compound) and Memantine may cause a minor interaction that can limit clinical effects when taken with Metformin
Topiramate (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Metformin
Topiramate (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Indomethacin (Compound) and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Metformin
Topiramate (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Midodrine (Compound) and Midodrine may cause a minor interaction that can limit clinical effects when taken with Metformin
Topiramate (Compound) binds GRIK2 (Gene) and GRIK2 (Gene) is downregulated by polycystic ovary syndrome (Disease) and polycystic ovary syndrome (Disease) is treated by Metformin (Compound)
Topiramate (Compound) treats obesity (Disease) and obesity (Disease) resembles polycystic ovary syndrome (Disease) and polycystic ovary syndrome (Disease) is treated by Metformin (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is associated with type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Metformin (Compound)
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by NDUFS8 (Gene) and NDUFS8 (Gene) is bound by Metformin (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Progesterone (Compound) and Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Metformin