DDInter350 DDInter809
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) BID
BID {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Chlorambucil (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is upregulated by Gatifloxacin (Compound)
Chlorambucil (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Gatifloxacin (Compound)
Chlorambucil (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Gatifloxacin (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Chlorambucil (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by BID (Gene) and BID (Gene) is upregulated by Gatifloxacin (Compound)
Chlorambucil (Compound) downregulates RPIA (Gene) and RPIA (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Gatifloxacin (Compound)
Chlorambucil (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Chlorambucil (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gatifloxacin (Compound)
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Gatifloxacin
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)