DDInter21 DDInter1853
An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Acitretin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Acitretin {u} (Compound) binds {v} (Gene) RARG
RARG {u} (Gene) is bound by {v} (Compound) Tretinoin
Acitretin {u} (Compound) upregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Acitretin {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Retinoids {u} (Pharmacologic Class) includes {v} (Compound) Tretinoin
Acitretin {u} (Compound) causes {v} (Side Effect) Skin fragility
Skin fragility {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Acitretin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Acitretin {u} (Compound) binds {v} (Gene) RARG
RARG {u} (Gene) is bound by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Acitretin (Compound) resembles Tretinoin (Compound)
Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Acitretin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Acitretin (Compound) binds RARG (Gene) and RARG (Gene) is bound by Tretinoin (Compound)
Acitretin (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Tretinoin (Compound)
Acitretin (Compound) is included by Retinoids (Pharmacologic Class) and Retinoids (Pharmacologic Class) includes Tretinoin (Compound)
Acitretin (Compound) causes Skin fragility (Side Effect) and Skin fragility (Side Effect) is caused by Tretinoin (Compound)
Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Acitretin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Acitretin (Compound) binds RARG (Gene) and RARG (Gene) is bound by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)