DDInter285 DDInter308
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Myelodysplastic syndromes (MDS) are a group of hematopoietic neoplasms that give rise to variable cytopenias progressing to secondary acute myeloid leukemia (sAML), which is invariably fatal if untreated.[A215082, A215092, A215097] Hypomethylating agents such as [decitabine] and [azacitidine] are used to treat MDS through inducing DNA hypomethylation and apoptosis of cancerous cells.[A215127, L14897] Although effective, these compounds are rapidly metabolized by cytidine deaminase (CDA) prior to reaching systemic circulation when administered orally, necessitating intramuscular or intravenous administration routes.[A215107, A215112, A215117, A215127] Cedazuridine is a fluorinated tetrahydrouridine derivative specifically designed to inhibit CDA and facilitate oral administration of hypomethylating agents.[A215107, A215112, A215117, A215127, L14897] Cedazuridine was first reported in 2014, and was subsequently approved by the FDA on July 7, 2020, in combination with [decitabine] for sale by Astex Pharmaceuticals Inc under the name INQOVI®.
Capecitabine {u} (Compound) treats {v} (Disease) colon cancer
Capecitabine {u} (Compound) binds {v} (Gene) TYMS
Capecitabine {u} (Compound) upregulates {v} (Gene) MCOLN1
Capecitabine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Capecitabine {u} (Compound) causes {v} (Side Effect) Tonsillitis
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Strontium chloride Sr-89
Capecitabine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Capecitabine (Compound) treats colon cancer (Disease)
Capecitabine (Compound) binds TYMS (Gene)
Capecitabine (Compound) upregulates MCOLN1 (Gene)
Capecitabine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Capecitabine (Compound) causes Tonsillitis (Side Effect)
Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Capecitabine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Capecitabine may lead to a major life threatening interaction when taken with Cladribine