DDInter1554 DDInter1055
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Quinapril {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Quinapril {u} (Compound) resembles {v} (Compound) Trandolapril
Trandolapril {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Quinapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) upregulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) resembles {v} (Compound) Benazepril
Benazepril {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) ALAS1
ALAS1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Quinapril {u} (Compound) binds {v} (Gene) ACE
ACE {u} (Gene) is associated with {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Quinapril (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Levofloxacin (Compound)
Quinapril (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Quinapril (Compound) resembles Trandolapril (Compound) and Trandolapril (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Levofloxacin (Compound)
Quinapril (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Quinapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Levofloxacin (Compound)
Quinapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) upregulates CPVL (Gene) and CPVL (Gene) is upregulated by Levofloxacin (Compound)
Quinapril (Compound) resembles Benazepril (Compound) and Benazepril (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Levofloxacin (Compound)
Quinapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)
Quinapril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Levofloxacin (Compound)
Quinapril (Compound) binds ACE (Gene) and ACE (Gene) is associated with chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)