DDInter1834 DDInter1168
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Topiramate {u} (Compound) causes {v} (Side Effect) Lacrimation increased
Lacrimation increased {u} (Side Effect) is caused by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methdilazine
Topiramate {u} (Compound) causes {v} (Side Effect) Lacrimation increased
Lacrimation increased {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Biperiden
Biperiden {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Topiramate {u} (Compound) causes {v} (Side Effect) Lacrimation increased
Lacrimation increased {u} (Side Effect) is caused by {v} (Compound) Echothiophate
Echothiophate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Procarbazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Triflupromazine (Compound) and Triflupromazine (Compound) resembles Methdilazine (Compound)
Topiramate (Compound) causes Lacrimation increased (Side Effect) and Lacrimation increased (Side Effect) is caused by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methdilazine (Compound)
Topiramate (Compound) causes Lacrimation increased (Side Effect) and Lacrimation increased (Side Effect) is caused by Morphine (Compound) and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Biperiden (Compound) and Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Topiramate (Compound) causes Lacrimation increased (Side Effect) and Lacrimation increased (Side Effect) is caused by Echothiophate (Compound) and Echothiophate may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound) and Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine