DDInter268 DDInter1717
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances [A177655, F4519]. Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076].
Calcitriol {u} (Compound) causes {v} (Side Effect) Haemolysis
Haemolysis {u} (Side Effect) is caused by {v} (Compound) Sucralfate
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sucralfate
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Paricalcitol {u} may lead to a major life threatening interaction when taken with {v} Sucralfate
Calcitriol {u} (Compound) causes {v} (Side Effect) Haemolysis
Haemolysis {u} (Side Effect) is caused by {v} (Compound) Aluminum hydroxide
Aluminum hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sucralfate
Calcitriol {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sotalol
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoniazid
Isoniazid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Calcitriol {u} (Compound) upregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is regulated by {v} (Gene) FGG
FGG {u} (Gene) is bound by {v} (Compound) Sucralfate
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Paricalcitol {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sucralfate
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digitoxin
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sucralfate
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sucralfate
Calcitriol (Compound) causes Haemolysis (Side Effect) and Haemolysis (Side Effect) is caused by Sucralfate (Compound)
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate
Calcitriol (Compound) resembles Paricalcitol (Compound) and Paricalcitol may lead to a major life threatening interaction when taken with Sucralfate
Calcitriol (Compound) causes Haemolysis (Side Effect) and Haemolysis (Side Effect) is caused by Aluminum hydroxide (Compound) and Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate
Calcitriol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Calcitriol (Compound) upregulates TXNRD1 (Gene) and TXNRD1 (Gene) is regulated by FGG (Gene) and FGG (Gene) is bound by Sucralfate (Compound)
Calcitriol (Compound) resembles Paricalcitol (Compound) and Paricalcitol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sucralfate (Compound)
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate