DDInter1853 DDInter1215
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) upregulates {v} (Gene) TLR4
TLR4 {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) downregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) upregulates {v} (Gene) PRSS23
PRSS23 {u} (Gene) is downregulated by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) causes {v} (Side Effect) Erythema nodosum
Erythema nodosum {u} (Side Effect) is caused by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mifepristone
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mifepristone
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Mifepristone
Tretinoin {u} (Compound) upregulates {v} (Gene) TLR4
TLR4 {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Tretinoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Tretinoin (Compound) upregulates TLR4 (Gene) and TLR4 (Gene) is upregulated by Mifepristone (Compound)
Tretinoin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Mifepristone (Compound)
Tretinoin (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Mifepristone (Compound)
Tretinoin (Compound) upregulates PRSS23 (Gene) and PRSS23 (Gene) is downregulated by Mifepristone (Compound)
Tretinoin (Compound) causes Erythema nodosum (Side Effect) and Erythema nodosum (Side Effect) is caused by Mifepristone (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Iso
Tretinoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Mifepristone (Compound)
Tretinoin (Compound) upregulates TLR4 (Gene) and TLR4 (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Mifepristone (Compound)