DDInter553 DDInter1376
A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Digitoxin {u} (Compound) resembles {v} (Compound) Digoxin
Digitoxin {u} (Compound) resembles {v} (Compound) Deslanoside
Digitoxin {u} (Compound) binds {v} (Gene) CYP3A4
Digitoxin {u} (Compound) upregulates {v} (Gene) PTBP2
Digitoxin {u} (Compound) downregulates {v} (Gene) ZDHHC6
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Teriparatide
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Digitoxin {u} may lead to a major life threatening interaction when taken with {v} Calcium gluconate
Digitoxin (Compound) resembles Digoxin (Compound)
Digitoxin (Compound) resembles Deslanoside (Compound)
Digitoxin (Compound) binds CYP3A4 (Gene)
Digitoxin (Compound) upregulates PTBP2 (Gene)
Digitoxin (Compound) downregulates ZDHHC6 (Gene)
Digitoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Digitoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Teriparatide
Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Digitoxin may lead to a major life threatening interaction when taken with Calcium gluconate