DDInter735 DDInter178
Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_. Human G-CSF is a glycoprotein that regulates the production and release of neutrophils from the bone marrow. Filgrastim mimics the biological actions of G-CSF to increase the levels of neutrophils in the blood. It has a number of therapeutic uses, including the management and prevention of infections and febrile neutropenia in patients receiving myelosuppressive chemotherapy or radiation therapy. It is also used to manage severe chronic neutropenia and mobilize hematopoietic progenitor cells to the
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomustine
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Interferon alfa-n1
Filgrastim {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lomustine
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfa-n1
Filgrastim may lead to a major life threatening interaction when taken with Cladribine