DDInter1042 DDInter1876
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Trimipramine {u} (Compound) resembles {v} (Compound) Clomipramine
Trimipramine {u} (Compound) binds {v} (Gene) CYP2C9
Trimipramine {u} (Compound) upregulates {v} (Gene) SUV39H1
Trimipramine {u} (Compound) downregulates {v} (Gene) CCDC86
Trimipramine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Trimipramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ammonium chloride
Trimipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Trimipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Trimipramine {u} may lead to a major life threatening interaction when taken with {v} Osimertinib
Trimipramine {u} may lead to a major life threatening interaction when taken with {v} Palonosetron
Trimipramine (Compound) resembles Clomipramine (Compound)
Trimipramine (Compound) binds CYP2C9 (Gene)
Trimipramine (Compound) upregulates SUV39H1 (Gene)
Trimipramine (Compound) downregulates CCDC86 (Gene)
Trimipramine (Compound) causes Diarrhoea (Side Effect)
Trimipramine may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Trimipramine may lead to a major life threatening interaction when taken with Osimertinib
Trimipramine may lead to a major life threatening interaction when taken with Palonosetron