DDInter1397 DDInter1526
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Paroxetine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Procarbazine
Paroxetine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) regulates {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Procarbazine
Paroxetine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is regulated by {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Atenolol
Atenolol {u} (Compound) resembles {v} (Compound) Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Hyporeflexia
Hyporeflexia {u} (Side Effect) is caused by {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Haemorrhagic disorder
Haemorrhagic disorder {u} (Side Effect) is caused by {v} (Compound) Trazodone
Trazodone {u} may lead to a major life threatening interaction when taken with {v} Procarbazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Nocturia
Nocturia {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Procarbazine
Paroxetine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Paroxetine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Paroxetine (Compound) downregulates DLD (Gene) and DLD (Gene) regulates MOK (Gene) and MOK (Gene) is upregulated by Procarbazine (Compound)
Paroxetine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is regulated by DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Paroxetine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Atenolol (Compound) and Atenolol (Compound) resembles Procarbazine (Compound)
Paroxetine (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Metoclopramide (Compound) and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Paroxetine (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Paroxetine (Compound) causes Hyporeflexia (Side Effect) and Hyporeflexia (Side Effect) is caused by Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine
Paroxetine (Compound) causes Haemorrhagic disorder (Side Effect) and Haemorrhagic disorder (Side Effect) is caused by Trazodone (Compound) and Trazodone may lead to a major life threatening interaction when taken with Procarbazine
Paroxetine (Compound) causes Nocturia (Side Effect) and Nocturia (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine