DDInter336 DDInter1490
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Dicyclomine
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA4
CA4 {u} (Gene) is bound by {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Saxagliptin
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polythiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Aplastic anaemia
Aplastic anaemia {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Dolasetron {u} may lead to a major life threatening interaction when taken with {v} Polythiazide
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Polythiazide (Compound)
Celecoxib (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Dicyclomine (Compound) and Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Polythiazide
Celecoxib (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide
Celecoxib (Compound) binds CA4 (Gene) and CA4 (Gene) is bound by Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Polythiazide (Compound)
Celecoxib (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Saxagliptin (Compound) and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide
Celecoxib (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mepenzolate (Compound) and Mepenzolate may cause a minor interaction that can limit clinical effects when taken with Polythiazide
Celecoxib (Compound) causes Aplastic anaemia (Side Effect) and Aplastic anaemia (Side Effect) is caused by Dolasetron (Compound) and Dolasetron may lead to a major life threatening interaction when taken with Polythiazide