DDInter576 DDInter1435
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
Disulfiram {u} (Compound) binds {v} (Gene) DBH
Disulfiram {u} (Compound) upregulates {v} (Gene) FHL2
Disulfiram {u} (Compound) is included by {v} (Pharmacologic Class) Acetyl Aldehyde Dehydrogenase Inhibitors
Disulfiram {u} (Compound) downregulates {v} (Gene) NR2F6
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Disulfiram (Compound) treats alcohol dependence (Disease)
Disulfiram (Compound) binds DBH (Gene)
Disulfiram (Compound) upregulates FHL2 (Gene)
Disulfiram (Compound) is included by Acetyl Aldehyde Dehydrogenase Inhibitors (Pharmacologic Class)
Disulfiram (Compound) downregulates NR2F6 (Gene)
Disulfiram (Compound) causes Neuropathy (Side Effect)