DDInter154 DDInter1372
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). On June 8, 2017, FDA requested Endo Pharmaceuticals to remove the medication from the market due to opioid misuse and abuse risks associated with the product's injectable reformulation.
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Oxymorphone
Azelastine {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Oxymorphone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxymorphone
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Dihydrocodeine
Dihydrocodeine {u} (Compound) resembles {v} (Compound) Oxymorphone
Azelastine {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Dihydrocodeine
Dihydrocodeine {u} (Compound) resembles {v} (Compound) Oxymorphone
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Oxymorphone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxycodone
Oxycodone {u} (Compound) resembles {v} (Compound) Oxymorphone
Azelastine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxymorphone
Azelastine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Oxymorphone
Azelastine {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxymorphone
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxymorphone (Compound)
Azelastine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Oxymorphone (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Oxymorphone
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dihydrocodeine (Compound) and Dihydrocodeine (Compound) resembles Oxymorphone (Compound)
Azelastine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Dihydrocodeine (Compound) and Dihydrocodeine (Compound) resembles Oxymorphone (Compound)
Azelastine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Oxymorphone (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Azelastine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Oxymorphone
Azelastine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Hydrocodone (Compound) and Hydrocodone (Compound) resembles Oxymorphone (Compound)
Azelastine (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Oxymorphone