DDInter162 DDInter92
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use.
Baclofen {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Buspirone
Buspirone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) causes {v} (Side Effect) Nocturia
Nocturia {u} (Side Effect) is caused by {v} (Compound) Dapagliflozin
Dapagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) causes {v} (Side Effect) Lightheadedness
Lightheadedness {u} (Side Effect) is caused by {v} (Compound) Prilocaine
Prilocaine {u} may lead to a major life threatening interaction when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Avanafil
Avanafil {u} may lead to a major life threatening interaction when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Procarbazine
Procarbazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may lead to a major life threatening interaction when taken with {v} Lithium carbonate
Lithium carbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Amitriptyline
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen {u} (Compound) is included by {v} (Pharmacologic Class) GABA A Agonists
GABA A Agonists {u} (Pharmacologic Class) includes {v} (Compound) Zaleplon
Zaleplon {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Baclofen (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Buspirone (Compound) and Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) causes Nocturia (Side Effect) and Nocturia (Side Effect) is caused by Dapagliflozin (Compound) and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) causes Lightheadedness (Side Effect) and Lightheadedness (Side Effect) is caused by Prilocaine (Compound) and Prilocaine may lead to a major life threatening interaction when taken with Amyl Nitrite
Baclofen (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Avanafil (Compound) and Avanafil may lead to a major life threatening interaction when taken with Amyl Nitrite
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Procarbazine (Compound) and Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may lead to a major life threatening interaction when taken with Lithium carbonate and Lithium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Amitriptyline (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Baclofen (Compound) is included by GABA A Agonists (Pharmacologic Class) and GABA A Agonists (Pharmacologic Class) includes Zaleplon (Compound) and Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite