DDInter387 DDInter576
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Cisplatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Disulfiram
Cisplatin {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Methylprednisolone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Methylprednisolone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Methylprednisolone {u} (Compound) downregulates {v} (Gene) FOSL1
FOSL1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valproic acid
Valproic acid {u} (Compound) binds {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Zidovudine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valproic acid
Valproic acid {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Cisplatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Disulfiram (Compound)
Cisplatin (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) downregulates FOSL1 (Gene) and FOSL1 (Gene) is upregulated by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Disulfiram (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Disulfiram (Compound)