DDInter1946 DDInter998
Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms. Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the treatment of onchocerciasis, but may also be effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis). Applied topically, it may be used in the treatment of head lice infestation. With the advent of 2020 and the COVID-19 pandemic, ivermectin began garnering notoriety due to its off-label use for the prophylaxis and treatment of COVID-19. While studies are still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and the clinical utility of this data remains unclear. Due to a number of factors - for example, the relatively low number of patients per trial and the speed at which these trials were conducted - studies on the use of ivermectin in COVID-19 have been fraught with statistical errors and accusations of plagiarism.[L36763,A238929] In addition, the use of aggregate patient data in large-scale meta-analyses (as opposed to individual patient data (IPD)) has been shown to disguise otherwise blatant data errors, such as extreme terminal digit bias and the duplication of blocks of patient records. Until high-quality, peer-reviewed data regarding both the safety and efficacy of ivermectin for COVID-19 in humans becomes available, the use of ivermectin for these purposes should be avoided in favour of thoroughly-vetted therapies (e.g. COVID-19 vaccines like [Comirnaty](https://go.drugbank.com/drugs/DB15696)).
Voriconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ivermectin
Voriconazole {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Ivermectin
Voriconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Dasatinib {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Ivermectin
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Ivermectin
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Hydrocortisone {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Ivermectin
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Dasatinib {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Vandetanib {u} (Compound) binds {v} (Gene) ERBB3
ERBB3 {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Clofarabine {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Vandetanib {u} (Compound) binds {v} (Gene) PLK4
PLK4 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivermectin (Compound)
Voriconazole (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Ivermectin (Compound)
Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with PGRMC1 (Gene) and PGRMC1 (Gene) is downregulated by Ivermectin (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Ivermectin (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Ivermectin (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Ivermectin (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ivermectin (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib (Compound) binds ERBB3 (Gene) and ERBB3 (Gene) is upregulated by Ivermectin (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is upregulated by Ivermectin (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib (Compound) binds PLK4 (Gene) and PLK4 (Gene) is downregulated by Ivermectin (Compound)