DDInter1867 DDInter1476
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Triflupromazine {u} (Compound) binds {v} (Gene) BCHE
BCHE {u} (Gene) is bound by {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) resembles {v} (Compound) Perphenazine
Perphenazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may lead to a major life threatening interaction when taken with {v} Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} (Compound) upregulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is upregulated by {v} (Compound) Clenbuterol
Clenbuterol {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Clenbuterol
Clenbuterol {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) regulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Pirbuterol
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nadolol
Nadolol {u} (Compound) resembles {v} (Compound) Pirbuterol
Triflupromazine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Terbutaline (Compound) and Terbutaline (Compound) resembles Pirbuterol (Compound)
Triflupromazine (Compound) resembles Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol (Compound) resembles Pirbuterol (Compound)
Triflupromazine (Compound) resembles Perphenazine (Compound) and Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol (Compound) resembles Pirbuterol (Compound)
Triflupromazine (Compound) resembles Clomipramine (Compound) and Clomipramine may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine (Compound) resembles Pirbuterol (Compound)
Triflupromazine (Compound) resembles Clomipramine (Compound) and Clomipramine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Pirbuterol (Compound)
Triflupromazine (Compound) resembles Thioridazine (Compound) and Thioridazine (Compound) upregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Pirbuterol (Compound)
Triflupromazine (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is upregulated by Clenbuterol (Compound) and Clenbuterol (Compound) resembles Pirbuterol (Compound)
Triflupromazine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Clenbuterol (Compound) and Clenbuterol (Compound) resembles Pirbuterol (Compound)
Triflupromazine (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) regulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Pirbuterol (Compound)
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nadolol (Compound) and Nadolol (Compound) resembles Pirbuterol (Compound)