DDInter948 DDInter133
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid. This conversion is a critical metabolic reaction involved in the production of several compounds involved in lipid metabolism and transport, including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very-low-density lipoprotein (VLDL). Prescribing statins is considered standard practice for patients following any cardiovascular event, and for people who are at moderate to high risk of developing cardiovascular disease. The evidence supporting statin use, coupled with minimal side effects and long term benefits, has resulted in wide use of this medication in North America.[A181087, A181406] Atorvastatin and other statins including [lovastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [simvastatin] are considered first-line treatment options for dyslipidemia.[A181087, A181406] The increasing use of this class of drugs is largely attributed to the rise in cardiovascular diseases (CVD) (such as heart attack, atherosclerosis, angina, peripheral artery disease, and stroke) in many countries. An elevated cholesterol level (elevated low-density lipoprotein (LDL) levels in particular) is a significant risk factor for the development of CVD.[A181087,A181553] Several landmark studies demonstrate that the use of statins is associated with both a reduction in LDL levels and CVD risk.[A181090,A181093,A181096,A181427,A181475,A181538] Statins were shown to reduce the incidences of all-cause mortality, including fatal and non-fatal CVD, as well as the need for surgical revascularization or angioplasty following a heart attack.[A181087, A181406] Some evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within five years) statin use leads to a 20%-22% relative reduction in the number of major cardiovascular events (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks.[A181397, A181403] Atorvastatin was first synthesized in 1985 by Dr. Bruce Roth and approved by the FDA in 1996. It is a pentasubstituted pyrrole formed by two contrasting moieties with an achiral heterocyclic core unit and a 3,5-dihydroxypentanoyl side chain identical to its parent compound. Unlike other members of the statin group, atorvastatin is an active compound and therefore does not require activation.
Atorvastatin {u} (Compound) resembles {v} (Compound) Conivaptan
Atorvastatin {u} (Compound) treats {v} (Disease) coronary artery disease
Atorvastatin {u} (Compound) binds {v} (Gene) SLCO1B3
Atorvastatin {u} (Compound) upregulates {v} (Gene) PRKCD
Atorvastatin {u} (Compound) downregulates {v} (Gene) CCDC86
Atorvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Medroxyprogesterone acetate
Atorvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Atorvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etoposide
Atorvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ivosidenib
Atorvastatin {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Atorvastatin (Compound) resembles Conivaptan (Compound)
Atorvastatin (Compound) treats coronary artery disease (Disease)
Atorvastatin (Compound) binds SLCO1B3 (Gene)
Atorvastatin (Compound) upregulates PRKCD (Gene)
Atorvastatin (Compound) downregulates CCDC86 (Gene)
Atorvastatin may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesterone acetate
Atorvastatin may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Etoposide
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Atorvastatin may lead to a major life threatening interaction when taken with Leflunomide