DDInter336 DDInter118
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism of alpha-adrenergic and 5-HT2A receptors.[L45859,A4393] Aripiprazole was given FDA approval on November 15, 2002.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Aripiprazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Nefazodone
Nefazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Vilazodone
Vilazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Nefazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Benign prostatic hyperplasia
Benign prostatic hyperplasia {u} (Side Effect) is caused by {v} (Compound) Famotidine
Famotidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Ischaemic stroke
Ischaemic stroke {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aripiprazole
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Aripiprazole
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trazodone
Trazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Aripiprazole (Compound)
Celecoxib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Aripiprazole (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nefazodone (Compound) and Nefazodone (Compound) resembles Aripiprazole (Compound)
Celecoxib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Vilazodone (Compound) and Vilazodone (Compound) resembles Aripiprazole (Compound)
Celecoxib (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Nefazodone (Compound) and Nefazodone (Compound) resembles Aripiprazole (Compound)
Celecoxib (Compound) causes Benign prostatic hyperplasia (Side Effect) and Benign prostatic hyperplasia (Side Effect) is caused by Famotidine (Compound) and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Celecoxib (Compound) causes Ischaemic stroke (Side Effect) and Ischaemic stroke (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Celecoxib (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Aripiprazole
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Aripiprazole (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trazodone (Compound) and Trazodone (Compound) resembles Aripiprazole (Compound)