DDInter593 DDInter1376
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Doxepin {u} (Compound) resembles {v} (Compound) Imipramine
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Doxepin {u} may lead to a major life threatening interaction when taken with {v} Cyclobenzaprine
Doxepin {u} (Compound) binds {v} (Gene) HTR2A
Doxepin {u} (Compound) upregulates {v} (Gene) MCOLN1
Doxepin {u} (Compound) palliates {v} (Disease) atopic dermatitis
Doxepin {u} (Compound) downregulates {v} (Gene) FAM69A
Doxepin {u} (Compound) causes {v} (Side Effect) Elevated mood
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Doxepin (Compound) resembles Thiothixene (Compound)
Doxepin (Compound) resembles Imipramine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Doxepin may lead to a major life threatening interaction when taken with Cyclobenzaprine
Doxepin (Compound) binds HTR2A (Gene)
Doxepin (Compound) upregulates MCOLN1 (Gene)
Doxepin (Compound) palliates atopic dermatitis (Disease)
Doxepin (Compound) downregulates FAM69A (Gene)
Doxepin (Compound) causes Elevated mood (Side Effect)