DDInter1460 DDInter255
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.[A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects.[A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Phenytoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Phenytoin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Phenytoin {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Phenytoin {u} (Compound) causes {v} (Side Effect) Rhinitis
Rhinitis {u} (Side Effect) is caused by {v} (Compound) Busulfan
Phenytoin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is regulated by {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Phenytoin {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is upregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Phenytoin {u} may lead to a major life threatening interaction when taken with {v} Nilotinib
Nilotinib {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Phenytoin {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Phenytoin {u} may lead to a major life threatening interaction when taken with {v} Bortezomib
Bortezomib {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Phenytoin {u} may lead to a major life threatening interaction when taken with {v} Nilotinib
Nilotinib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Phenytoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Phenytoin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Phenytoin (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is downregulated by Busulfan (Compound)
Phenytoin (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Busulfan (Compound)
Phenytoin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is regulated by PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Phenytoin (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is upregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Phenytoin (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)