DDInter1233 DDInter1731
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Sunitinib
Mitotane {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is regulated by {v} (Gene) MAP2K1
MAP2K1 {u} (Gene) is bound by {v} (Compound) Sunitinib
Mitotane {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sunitinib
Mitotane {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Sunitinib
Mitotane {u} (Compound) causes {v} (Side Effect) Protein urine present
Protein urine present {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Mitotane {u} (Compound) causes {v} (Side Effect) Adrenal insufficiency
Adrenal insufficiency {u} (Side Effect) is caused by {v} (Compound) Tizanidine
Tizanidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) regulates {v} (Gene) CSNK1E
CSNK1E {u} (Gene) is bound by {v} (Compound) Sunitinib
Mitotane {u} (Compound) resembles {v} (Compound) Delorazepam
Delorazepam {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Sunitinib
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Sunitinib (Compound)
Mitotane (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Sunitinib (Compound)
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is regulated by MAP2K1 (Gene) and MAP2K1 (Gene) is bound by Sunitinib (Compound)
Mitotane (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Sunitinib
Mitotane (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Metoclopramide (Compound) and Metoclopramide (Compound) resembles Sunitinib (Compound)
Mitotane (Compound) causes Protein urine present (Side Effect) and Protein urine present (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Mitotane (Compound) causes Adrenal insufficiency (Side Effect) and Adrenal insufficiency (Side Effect) is caused by Tizanidine (Compound) and Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) regulates CSNK1E (Gene) and CSNK1E (Gene) is bound by Sunitinib (Compound)
Mitotane (Compound) resembles Delorazepam (Compound) and Delorazepam (Compound) resembles Clozapine (Compound) and Clozapine may lead to a major life threatening interaction when taken with Sunitinib