DDInter1123 DDInter776
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major clinical advantage of formoterol over other inhaled beta-agonists is its rapid onset of action (2-3 minutes), which is at least as fast as [salbutamol], combined with a long duration of action (12 hours) - for this reason, treatment guidelines for asthma recommend its use as both a reliever and maintenance medication. It is available as a single-entity product [L10986,L11223] and in several formulations in combination with both inhaled corticosteroids [L10995,L10619] and long-acting muscarinic antagonists.[L10992,L10989]
Mannitol {u} (Compound) causes {v} (Side Effect) Bronchitis
Bronchitis {u} (Side Effect) is caused by {v} (Compound) Formoterol
Mannitol {u} (Compound) causes {v} (Side Effect) Bronchitis
Bronchitis {u} (Side Effect) is caused by {v} (Compound) Arformoterol
Arformoterol {u} (Compound) resembles {v} (Compound) Formoterol
Mannitol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Labetalol
Labetalol {u} may lead to a major life threatening interaction when taken with {v} Formoterol
Mannitol {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Isoprenaline
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Formoterol
Mannitol {u} (Compound) resembles {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Formoterol
Mannitol {u} (Compound) causes {v} (Side Effect) Bronchitis
Bronchitis {u} (Side Effect) is caused by {v} (Compound) Ciclesonide
Ciclesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Formoterol
Mannitol {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Formoterol
Mannitol {u} (Compound) causes {v} (Side Effect) Lung disorder
Lung disorder {u} (Side Effect) is caused by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Formoterol
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Formoterol
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Timolol
Timolol {u} may lead to a major life threatening interaction when taken with {v} Formoterol
Mannitol (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Formoterol (Compound)
Mannitol (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Arformoterol (Compound) and Arformoterol (Compound) resembles Formoterol (Compound)
Mannitol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Labetalol (Compound) and Labetalol may lead to a major life threatening interaction when taken with Formoterol
Mannitol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Isoprenaline (Compound) and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Mannitol (Compound) resembles Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Formoterol (Compound)
Mannitol (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Ciclesonide (Compound) and Ciclesonide may cause a minor interaction that can limit clinical effects when taken with Formoterol
Mannitol (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Prednisone (Compound) and Prednisone may cause a minor interaction that can limit clinical effects when taken with Formoterol
Mannitol (Compound) causes Lung disorder (Side Effect) and Lung disorder (Side Effect) is caused by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound) and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Timolol (Compound) and Timolol may lead to a major life threatening interaction when taken with Formoterol