DDInter1194 DDInter1233
An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Methysergide {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Methysergide {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Mitotane
Methysergide {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is regulated by {v} (Gene) ZNF395
ZNF395 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Methysergide {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Methysergide {u} (Compound) resembles {v} (Compound) Lisuride
Lisuride {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Mitotane
Methysergide {u} (Compound) resembles {v} (Compound) Nicergoline
Nicergoline {u} (Compound) downregulates {v} (Gene) PAPD7
PAPD7 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Methysergide {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Methysergide {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Methysergide {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Mitotane
Methysergide {u} (Compound) binds {v} (Gene) SIGMAR1
SIGMAR1 {u} (Gene) is bound by {v} (Compound) Mazindol
Mazindol {u} (Compound) resembles {v} (Compound) Mitotane
Methysergide (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Mitotane (Compound)
Methysergide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Mitotane (Compound)
Methysergide (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is regulated by ZNF395 (Gene) and ZNF395 (Gene) is downregulated by Mitotane (Compound)
Methysergide (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Methysergide (Compound) resembles Lisuride (Compound) and Lisuride (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Mitotane (Compound)
Methysergide (Compound) resembles Nicergoline (Compound) and Nicergoline (Compound) downregulates PAPD7 (Gene) and PAPD7 (Gene) is downregulated by Mitotane (Compound)
Methysergide (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Mitotane (Compound)
Methysergide (Compound) resembles Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Mitotane (Compound)
Methysergide (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Mitotane (Compound)
Methysergide (Compound) binds SIGMAR1 (Gene) and SIGMAR1 (Gene) is bound by Mazindol (Compound) and Mazindol (Compound) resembles Mitotane (Compound)