DDInter1233 DDInter679
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and creams.[L11485,L11488,L11491, L11494,L11497,L11500,L11503] When used for oral or IM administration, estradiol is commonly synthesized as a pro-drug ester (such as , , , , and ). Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain. (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination oral contraceptive pills (OCPs). Ethinyl estradiol is different from estradiol due to its higher biovailability and increased resistance to metabolism, rendering it more suitable for oral administration.
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Estradiol
Mitotane {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Estradiol
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Estradiol
Mitotane {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Estradiol
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Estradiol
Mitotane {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is associated with {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is treated by {v} (Compound) Estradiol
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is regulated by {v} (Gene) UBP1
UBP1 {u} (Gene) is upregulated by {v} (Compound) Estradiol
Mitotane {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is upregulated by {v} (Compound) Estradiol valerate/Dienogest
Estradiol valerate/Dienogest {u} (Compound) resembles {v} (Compound) Estradiol
Mitotane {u} (Compound) downregulates {v} (Gene) DNMT3A
DNMT3A {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Estradiol
Mitotane {u} (Compound) downregulates {v} (Gene) PEG10
PEG10 {u} (Gene) is regulated by {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Estradiol
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Estradiol (Compound)
Mitotane (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Estradiol (Compound)
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Estradiol (Compound)
Mitotane (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Estradiol (Compound)
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Testosterone (Compound) and Testosterone (Compound) resembles Estradiol (Compound)
Mitotane (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is associated with prostate cancer (Disease) and prostate cancer (Disease) is treated by Estradiol (Compound)
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is regulated by UBP1 (Gene) and UBP1 (Gene) is upregulated by Estradiol (Compound)
Mitotane (Compound) downregulates NVL (Gene) and NVL (Gene) is upregulated by Estradiol valerate/Dienogest (Compound) and Estradiol valerate/Dienogest (Compound) resembles Estradiol (Compound)
Mitotane (Compound) downregulates DNMT3A (Gene) and DNMT3A (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Estradiol (Compound)
Mitotane (Compound) downregulates PEG10 (Gene) and PEG10 (Gene) is regulated by AR (Gene) and AR (Gene) is bound by Estradiol (Compound)