DDInter1759 DDInter1376
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Telmisartan {u} (Compound) resembles {v} (Compound) Candesartan
Telmisartan {u} (Compound) treats {v} (Disease) hypertension
Telmisartan {u} (Compound) binds {v} (Gene) ABCG2
Telmisartan {u} (Compound) is included by {v} (Pharmacologic Class) Angiotensin 2 Receptor Antagonists
Telmisartan {u} (Compound) causes {v} (Side Effect) Cerebrovascular disorder
Telmisartan (Compound) resembles Candesartan (Compound)
Telmisartan (Compound) treats hypertension (Disease)
Telmisartan (Compound) binds ABCG2 (Gene)
Telmisartan (Compound) is included by Angiotensin 2 Receptor Antagonists (Pharmacologic Class)
Telmisartan (Compound) causes Cerebrovascular disorder (Side Effect)