DDInter1789 DDInter1798
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Thiothixene
Thalidomide {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Thiothixene
Thalidomide {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Olopatadine
Olopatadine {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Thiothixene (Compound)
Thalidomide may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Thiothixene (Compound)
Thalidomide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thiothixene (Compound)
Thalidomide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Thiothixene (Compound)
Thalidomide (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Thiothixene (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Olopatadine (Compound) and Olopatadine (Compound) resembles Thiothixene (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Doxepin (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)