DDInter596 DDInter1917
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
Doxorubicin {u} (Compound) treats {v} (Disease) thyroid cancer
thyroid cancer {u} (Disease) is treated by {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) downregulates {v} (Gene) PLK4
PLK4 {u} (Gene) is bound by {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) upregulates {v} (Gene) STK10
STK10 {u} (Gene) is bound by {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) causes {v} (Side Effect) Blood creatinine increased
Blood creatinine increased {u} (Side Effect) is caused by {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Doxorubicin {u} (Compound) treats {v} (Disease) thyroid cancer
thyroid cancer {u} (Disease) is associated with {v} (Gene) RET
RET {u} (Gene) is bound by {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Erlotinib
Erlotinib {u} (Compound) resembles {v} (Compound) Vandetanib
Doxorubicin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Rifampicin
Rifampicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vandetanib
Doxorubicin {u} (Compound) downregulates {v} (Gene) PLK4
PLK4 {u} (Gene) regulates {v} (Gene) MAP2K5
MAP2K5 {u} (Gene) is bound by {v} (Compound) Vandetanib
Doxorubicin (Compound) treats thyroid cancer (Disease) and thyroid cancer (Disease) is treated by Vandetanib (Compound)
Doxorubicin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Vandetanib (Compound)
Doxorubicin (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) is bound by Vandetanib (Compound)
Doxorubicin (Compound) upregulates STK10 (Gene) and STK10 (Gene) is bound by Vandetanib (Compound)
Doxorubicin (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Vandetanib (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may lead to a major life threatening interaction when taken with Vandetanib
Doxorubicin (Compound) treats thyroid cancer (Disease) and thyroid cancer (Disease) is associated with RET (Gene) and RET (Gene) is bound by Vandetanib (Compound)
Doxorubicin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Erlotinib (Compound) and Erlotinib (Compound) resembles Vandetanib (Compound)
Doxorubicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Rifampicin (Compound) and Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib
Doxorubicin (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) regulates MAP2K5 (Gene) and MAP2K5 (Gene) is bound by Vandetanib (Compound)