DDInter864 DDInter1082
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that need to be replaced every 52 weeks.[L41700,L41715,L41755] Initially, histrelin implants were developed to reduce testosterone to castration levels in patients with advanced prostate cancer. The Vantas product was approved by the FDA in October 2004 for the palliative treatment of this condition. Vantas was later discontinued by Endo Pharmaceuticals Inc. on September 21, 2021. GnRH agonists are the first line of treatment for children with central precocious puberty (CPP) due to their capacity to reduce LH levels and the concentration of
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Histrelin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Histrelin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risperidone
Histrelin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium citrate
Histrelin {u} may lead to a major life threatening interaction when taken with {v} Arsenic trioxide
Histrelin {u} may lead to a major life threatening interaction when taken with {v} Lefamulin
Histrelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Histrelin may lead to a major life threatening interaction when taken with Arsenic trioxide
Histrelin may lead to a major life threatening interaction when taken with Lefamulin