DDInter162 DDInter343
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _allergic rhinitis_. The prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals . Furthermore, some antihistamine agents that are used to treat this condition cause undesirable, sedating effects . Cetirizine is one of the first second-generation H1 antihistamines (SGAHs) formulated to selectively inhibit the H1 receptor without sedating effects .
Baclofen {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Baclofen {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Cyclizine
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Baclofen {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Fexofenadine
Fexofenadine {u} (Compound) resembles {v} (Compound) Cetirizine
Baclofen {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Cetirizine
Baclofen {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Lorazepam
Lorazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Procarbazine
Procarbazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Baclofen {u} (Compound) causes {v} (Side Effect) Haematuria
Haematuria {u} (Side Effect) is caused by {v} (Compound) Theophylline
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cetirizine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) causes {v} (Side Effect) Bronchospasm
Bronchospasm {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Baclofen (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Cetirizine (Compound)
Baclofen (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Cyclizine (Compound) and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Baclofen (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Fexofenadine (Compound) and Fexofenadine (Compound) resembles Cetirizine (Compound)
Baclofen (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Cetirizine (Compound)
Baclofen (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Lorazepam (Compound) and Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Procarbazine (Compound) and Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Baclofen (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Theophylline (Compound) and Theophylline may cause a minor interaction that can limit clinical effects when taken with Cetirizine
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Cetirizine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Cetirizine (Compound)
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine