DDInter458 DDInter812
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA approval on 21 December 1981.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) downregulates {v} (Gene) EZH2
EZH2 {u} (Gene) is upregulated by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLT1B
GOLT1B {u} (Gene) is downregulated by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemfibrozil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1B1
SLCO1B1 {u} (Gene) is bound by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemfibrozil
Cyclosporine {u} (Compound) downregulates {v} (Gene) EZH2
EZH2 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is upregulated by {v} (Compound) Gemfibrozil
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLT1B
GOLT1B {u} (Gene) is regulated by {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Gemfibrozil
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Gemfibrozil (Compound)
Cyclosporine (Compound) downregulates EZH2 (Gene) and EZH2 (Gene) is upregulated by Gemfibrozil (Compound)
Cyclosporine (Compound) upregulates GOLT1B (Gene) and GOLT1B (Gene) is downregulated by Gemfibrozil (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Gemfibrozil (Compound)
Cyclosporine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Gemfibrozil (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Gemfibrozil (Compound)
Cyclosporine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Cyclosporine (Compound) downregulates EZH2 (Gene) and EZH2 (Gene) is regulated by SRC (Gene) and SRC (Gene) is upregulated by Gemfibrozil (Compound)
Cyclosporine (Compound) upregulates GOLT1B (Gene) and GOLT1B (Gene) is regulated by ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Gemfibrozil (Compound)