DDInter1294 DDInter1033
Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Nilutamide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Leflunomide
Nilutamide {u} (Compound) causes {v} (Side Effect) Interstitial lung disease
Interstitial lung disease {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Nilutamide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Losartan
Losartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Nilutamide {u} (Compound) causes {v} (Side Effect) Interstitial lung disease
Interstitial lung disease {u} (Side Effect) is caused by {v} (Compound) Lapatinib
Lapatinib {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Nilutamide {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Nilutamide {u} (Compound) causes {v} (Side Effect) Arthritis
Arthritis {u} (Side Effect) is caused by {v} (Compound) Losartan
Losartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Nilutamide {u} (Compound) causes {v} (Side Effect) Interstitial pneumonia
Interstitial pneumonia {u} (Side Effect) is caused by {v} (Compound) Melphalan
Melphalan {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Nilutamide {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) binds {v} (Gene) AHR
AHR {u} (Gene) is bound by {v} (Compound) Leflunomide
Nilutamide {u} (Compound) resembles {v} (Compound) Enzalutamide
Enzalutamide {u} (Compound) resembles {v} (Compound) Bicalutamide
Bicalutamide {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Nilutamide {u} (Compound) resembles {v} (Compound) Nitisinone
Nitisinone {u} (Compound) causes {v} (Side Effect) Melaena
Melaena {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Nilutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Nilutamide (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Leflunomide (Compound)
Nilutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Losartan (Compound) and Losartan may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Nilutamide (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Lapatinib (Compound) and Lapatinib may lead to a major life threatening interaction when taken with Leflunomide
Nilutamide (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Telbivudine (Compound) and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Nilutamide (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Losartan (Compound) and Losartan may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Nilutamide (Compound) causes Interstitial pneumonia (Side Effect) and Interstitial pneumonia (Side Effect) is caused by Melphalan (Compound) and Melphalan may lead to a major life threatening interaction when taken with Leflunomide
Nilutamide (Compound) resembles Flutamide (Compound) and Flutamide (Compound) binds AHR (Gene) and AHR (Gene) is bound by Leflunomide (Compound)
Nilutamide (Compound) resembles Enzalutamide (Compound) and Enzalutamide (Compound) resembles Bicalutamide (Compound) and Bicalutamide may lead to a major life threatening interaction when taken with Leflunomide
Nilutamide (Compound) resembles Nitisinone (Compound) and Nitisinone (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Leflunomide (Compound)