DDInter427 DDInter1376
Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Cocaine {u} (Compound) resembles {v} (Compound) Hexylcaine
Cocaine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Cocaine {u} (Compound) causes {v} (Side Effect) Agitation
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide dinitrate
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepivacaine
Cocaine {u} may lead to a major life threatening interaction when taken with {v} Salmeterol
Cocaine {u} may lead to a major life threatening interaction when taken with {v} Protriptyline
Cocaine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Iobenguane
Cocaine (Compound) resembles Hexylcaine (Compound)
Cocaine (Compound) binds CYP3A7-CYP3A51P (Gene)
Cocaine (Compound) causes Agitation (Side Effect)
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide dinitrate
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Mepivacaine
Cocaine may lead to a major life threatening interaction when taken with Salmeterol
Cocaine may lead to a major life threatening interaction when taken with Protriptyline
Cocaine (Compound) resembles Ioflupane I-123 (Compound) and Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Cocaine may lead to a major life threatening interaction when taken with Iobenguane