DDInter38 DDInter255
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Aldesleukin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Cinoxacin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Busulfan
Aldesleukin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Ofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Aldesleukin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Aldesleukin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Ofloxacin {u} (Compound) upregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Aldesleukin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Gatifloxacin {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epirubicin
Epirubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Aldesleukin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enoxacin
Enoxacin {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methyldopa
Methyldopa {u} (Compound) upregulates {v} (Gene) NFATC3
NFATC3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentostatin
Pentostatin {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Busulfan
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin and Cinoxacin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Busulfan (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) upregulates FKBP14 (Gene) and FKBP14 (Gene) is downregulated by Busulfan (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin and Gatifloxacin (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Busulfan (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Busulfan (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa (Compound) upregulates NFATC3 (Gene) and NFATC3 (Gene) is upregulated by Busulfan (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Pentostatin and Pentostatin (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Busulfan (Compound)