DDInter458 DDInter330
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis, loss of cell integrity, and ultimately bacterial cell death.[A232920, A232925, A232930] Ceftazidime is a third-generation cephalosporin with broad-spectrum antibacterial activity, including against some treatment-resistant bacteria such as _Pseudomonas aeruginosa_. Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone or in combination with the non-β-lactam β-lactamase inhibitor [avibactam] to treat a variety of bacterial infections.[L32935, L32940]
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ceftazidime
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Ceftazidime
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ceftriaxone
Ceftriaxone {u} (Compound) resembles {v} (Compound) Ceftazidime
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Cefpodoxime
Cefpodoxime {u} (Compound) resembles {v} (Compound) Ceftazidime
Cyclosporine {u} (Compound) causes {v} (Side Effect) Lethargy
Lethargy {u} (Side Effect) is caused by {v} (Compound) Acyclovir
Acyclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ceftazidime
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Bleomycin
Bleomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ceftazidime
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Cefalotin
Cefalotin {u} (Compound) resembles {v} (Compound) Ceftazidime
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Acyclovir
Acyclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ceftazidime
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Cefuroxime
Cefuroxime {u} (Compound) resembles {v} (Compound) Ceftazidime
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Cefuroxime
Cefuroxime {u} (Compound) resembles {v} (Compound) Ceftazidime
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ceftazidime (Compound)
Cyclosporine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Ceftazidime (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ceftriaxone (Compound) and Ceftriaxone (Compound) resembles Ceftazidime (Compound)
Cyclosporine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Cefpodoxime (Compound) and Cefpodoxime (Compound) resembles Ceftazidime (Compound)
Cyclosporine (Compound) causes Lethargy (Side Effect) and Lethargy (Side Effect) is caused by Acyclovir (Compound) and Acyclovir may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime
Cyclosporine (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Bleomycin (Compound) and Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Cefalotin (Compound) and Cefalotin (Compound) resembles Ceftazidime (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Acyclovir (Compound) and Acyclovir may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Cefuroxime (Compound) and Cefuroxime (Compound) resembles Ceftazidime (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Cefuroxime (Compound) and Cefuroxime (Compound) resembles Ceftazidime (Compound)