DDInter1305 DDInter1782
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
Nitroprusside {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Ambenonium
Ambenonium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracosactide
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Isoprenaline
Isoprenaline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracosactide
Nitroprusside {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Neostigmine
Neostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracosactide
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracosactide
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Tetracosactide
Nitroprusside (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Ambenonium (Compound) and Ambenonium may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Isoprenaline (Compound) and Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Nitroprusside (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Neostigmine (Compound) and Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Tetracosactide