DDInter656 DDInter69
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
Eplerenone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Eplerenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Eplerenone {u} (Compound) resembles {v} (Compound) Spironolactone
Eplerenone {u} (Compound) treats {v} (Disease) hypertension
Eplerenone {u} (Compound) binds {v} (Gene) CYP3A5
Eplerenone {u} (Compound) is included by {v} (Pharmacologic Class) Aldosterone Antagonists
Eplerenone {u} (Compound) downregulates {v} (Gene) PTPRK
Eplerenone {u} (Compound) causes {v} (Side Effect) Upper respiratory tract infection
Eplerenone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Apalutamide
Eplerenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabilone
Eplerenone (Compound) resembles Methyltestosterone (Compound)
Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Eplerenone (Compound) resembles Spironolactone (Compound)
Eplerenone (Compound) treats hypertension (Disease)
Eplerenone (Compound) binds CYP3A5 (Gene)
Eplerenone (Compound) is included by Aldosterone Antagonists (Pharmacologic Class)
Eplerenone (Compound) downregulates PTPRK (Gene)
Eplerenone (Compound) causes Upper respiratory tract infection (Side Effect)
Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Nabilone