DDInter583 DDInter1180
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia.[L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia. Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Donepezil {u} (Compound) resembles {v} (Compound) Doxazosin
Donepezil {u} (Compound) resembles {v} (Compound) Moexipril
Donepezil {u} (Compound) treats {v} (Disease) Alzheimer's disease
Donepezil {u} (Compound) binds {v} (Gene) CYP2D6
Donepezil {u} (Compound) upregulates {v} (Gene) MAPKAPK5
Donepezil {u} (Compound) downregulates {v} (Gene) CCNB2
Donepezil {u} (Compound) causes {v} (Side Effect) Abdominal pain upper
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cobicistat
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zafirlukast
Donepezil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Donepezil (Compound) resembles Doxazosin (Compound)
Donepezil (Compound) resembles Moexipril (Compound)
Donepezil (Compound) treats Alzheimer's disease (Disease)
Donepezil (Compound) binds CYP2D6 (Gene)
Donepezil (Compound) upregulates MAPKAPK5 (Gene)
Donepezil (Compound) downregulates CCNB2 (Gene)
Donepezil (Compound) causes Abdominal pain upper (Side Effect)
Donepezil may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Donepezil may cause a minor interaction that can limit clinical effects when taken with Zafirlukast
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin