DDInter758 DDInter856
Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Fluoxetine {u} (Compound) resembles {v} (Compound) Orphenadrine
Fluoxetine {u} (Compound) resembles {v} (Compound) Duloxetine
Fluoxetine {u} (Compound) binds {v} (Gene) CYP2D6
Fluoxetine {u} (Compound) upregulates {v} (Gene) ALDOC
Fluoxetine {u} (Compound) palliates {v} (Disease) schizophrenia
Fluoxetine {u} (Compound) downregulates {v} (Gene) RPS4Y1
Fluoxetine {u} (Compound) causes {v} (Side Effect) Cystitis
Fluoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Fluoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levothyroxine
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Fluoxetine (Compound) resembles Orphenadrine (Compound)
Fluoxetine (Compound) resembles Duloxetine (Compound)
Fluoxetine (Compound) binds CYP2D6 (Gene)
Fluoxetine (Compound) upregulates ALDOC (Gene)
Fluoxetine (Compound) palliates schizophrenia (Disease)
Fluoxetine (Compound) downregulates RPS4Y1 (Gene)
Fluoxetine (Compound) causes Cystitis (Side Effect)
Fluoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Fluoxetine may cause a minor interaction that can limit clinical effects when taken with Levothyroxine
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine