DDInter845 DDInter1376
Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Guanadrel {u} (Compound) treats {v} (Disease) hypertension
Guanadrel {u} (Compound) binds {v} (Gene) SLC6A2
Guanadrel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ephedrine
Guanadrel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Guanadrel {u} may lead to a major life threatening interaction when taken with {v} Minoxidil
Guanadrel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Iobenguane
Guanadrel (Compound) treats hypertension (Disease)
Guanadrel (Compound) binds SLC6A2 (Gene)
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Guanadrel may lead to a major life threatening interaction when taken with Minoxidil
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Guanadrel may lead to a major life threatening interaction when taken with Iobenguane