DDInter1020 DDInter690
Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries. Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Lamotrigine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Proguanil
Proguanil {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} (Compound) resembles {v} (Compound) Triamterene
Triamterene {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is associated with {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} (Compound) resembles {v} (Compound) and {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pyrimethamine
Pyrimethamine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} (Compound) upregulates {v} (Gene) ST3GAL5
ST3GAL5 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine {u} (Compound) downregulates {v} (Gene) IPO13
IPO13 {u} (Gene) is regulated by {v} (Gene) GRIN3A
GRIN3A {u} (Gene) is bound by {v} (Compound) Ethanol
Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Lamotrigine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Proguanil and Proguanil (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Lamotrigine (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Lamotrigine (Compound) resembles Triamterene (Compound) and Triamterene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ethanol (Compound)
Lamotrigine (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is associated with CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ethanol (Compound)
Lamotrigine (Compound) resembles Pyrimethamine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Pyrimethamine and Pyrimethamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ethanol (Compound)
Lamotrigine (Compound) upregulates ST3GAL5 (Gene) and ST3GAL5 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Ethanol (Compound)
Lamotrigine (Compound) downregulates IPO13 (Gene) and IPO13 (Gene) is regulated by GRIN3A (Gene) and GRIN3A (Gene) is bound by Ethanol (Compound)