DDInter1174 DDInter690
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Voriconazole
Voriconazole {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Lansoprazole
Lansoprazole {u} (Compound) binds {v} (Gene) CYP4A11
CYP4A11 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Haloperidol
Haloperidol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) downregulates {v} (Gene) ADH1B
ADH1B {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Folic acid
Folic acid {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} (Compound) upregulates {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Ethanol
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Lansoprazole and Lansoprazole (Compound) binds CYP4A11 (Gene) and CYP4A11 (Gene) is bound by Ethanol (Compound)
Methotrexate may cause a minor interaction that can limit clinical effects when taken with Haloperidol and Haloperidol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Methotrexate may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Methotrexate (Compound) treats bone cancer (Disease) and bone cancer (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Methotrexate (Compound) treats breast cancer (Disease) and breast cancer (Disease) downregulates ADH1B (Gene) and ADH1B (Gene) is bound by Ethanol (Compound)
Methotrexate (Compound) resembles Folic acid (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Folic acid and Folic acid (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Ethanol (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate (Compound) upregulates CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Ethanol (Compound)