DDInter596 DDInter1494
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Posaconazole
Doxorubicin {u} (Compound) causes {v} (Side Effect) Kidney function abnormal
Kidney function abnormal {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Posaconazole
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Posaconazole
Doxorubicin {u} (Compound) causes {v} (Side Effect) Kidney function abnormal
Kidney function abnormal {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Posaconazole
Doxorubicin {u} (Compound) causes {v} (Side Effect) Prothrombin level increased
Prothrombin level increased {u} (Side Effect) is caused by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Posaconazole
Doxorubicin {u} (Compound) causes {v} (Side Effect) Petechiae
Petechiae {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Posaconazole
Doxorubicin {u} (Compound) causes {v} (Side Effect) Musculoskeletal pain
Musculoskeletal pain {u} (Side Effect) is caused by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Posaconazole
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Posaconazole
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} (Compound) causes {v} (Side Effect) Kidney function abnormal
Kidney function abnormal {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Doxorubicin (Compound) causes Kidney function abnormal (Side Effect) and Kidney function abnormal (Side Effect) is caused by Posaconazole (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Itraconazole (Compound) and Itraconazole (Compound) resembles Posaconazole (Compound)
Doxorubicin (Compound) causes Kidney function abnormal (Side Effect) and Kidney function abnormal (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Posaconazole (Compound)
Doxorubicin (Compound) causes Prothrombin level increased (Side Effect) and Prothrombin level increased (Side Effect) is caused by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole
Doxorubicin (Compound) causes Petechiae (Side Effect) and Petechiae (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Posaconazole
Doxorubicin (Compound) causes Musculoskeletal pain (Side Effect) and Musculoskeletal pain (Side Effect) is caused by Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin (Compound) causes Kidney function abnormal (Side Effect) and Kidney function abnormal (Side Effect) is caused by Posaconazole (Compound)