DDInter54 DDInter576
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse effects are generally related to the sedation it can cause. Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. Alprazolam was given FDA approval on October 16, 1981.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Alprazolam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) regulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) regulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Alprazolam {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) interacts with {v} (Gene) DDIT3
DDIT3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Alprazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Alprazolam (Compound) downregulates MYC (Gene) and MYC (Gene) is upregulated by Disulfiram (Compound)
Alprazolam (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Disulfiram (Compound)
Alprazolam (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Disulfiram (Compound)
Alprazolam (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Alprazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Alprazolam (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)
Alprazolam (Compound) downregulates MYC (Gene) and MYC (Gene) regulates CTSL (Gene) and CTSL (Gene) is upregulated by Disulfiram (Compound)
Alprazolam (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) regulates CTSL (Gene) and CTSL (Gene) is upregulated by Disulfiram (Compound)
Alprazolam (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) interacts with DDIT3 (Gene) and DDIT3 (Gene) is upregulated by Disulfiram (Compound)