DDInter1009 DDInter899
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Ketoprofen {u} (Compound) resembles {v} (Compound) Alvimopan
Ketoprofen {u} (Compound) resembles {v} (Compound) Tropicamide
Ketoprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Ketoprofen {u} (Compound) binds {v} (Gene) CXCL8
Ketoprofen {u} (Compound) upregulates {v} (Gene) AGR2
Ketoprofen {u} (Compound) palliates {v} (Disease) osteoarthritis
Ketoprofen {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Ketoprofen {u} (Compound) downregulates {v} (Gene) THAP11
Ketoprofen {u} (Compound) causes {v} (Side Effect) Sepsis
Ketoprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ketoprofen (Compound) resembles Alvimopan (Compound)
Ketoprofen (Compound) resembles Tropicamide (Compound)
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Ketoprofen (Compound) binds CXCL8 (Gene)
Ketoprofen (Compound) upregulates AGR2 (Gene)
Ketoprofen (Compound) palliates osteoarthritis (Disease)
Ketoprofen (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Ketoprofen (Compound) downregulates THAP11 (Gene)
Ketoprofen (Compound) causes Sepsis (Side Effect)
Ketoprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine