DDInter416 DDInter1174
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Clotrimazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Methotrexate
Clotrimazole {u} (Compound) causes {v} (Side Effect) Cystitis
Cystitis {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Clotrimazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Clotrimazole {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Tetrahydrofolic acid
Tetrahydrofolic acid {u} (Compound) resembles {v} (Compound) Methotrexate
Clotrimazole {u} (Compound) causes {v} (Side Effect) Cystitis
Cystitis {u} (Side Effect) is caused by {v} (Compound) Lamotrigine
Lamotrigine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methotrexate
Clotrimazole {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Raltitrexed
Raltitrexed {u} (Compound) resembles {v} (Compound) Methotrexate
Clotrimazole {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Amphotericin B
Amphotericin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Clotrimazole {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Hydroxychloroquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methotrexate
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Phenylbutazone
Phenylbutazone {u} may lead to a major life threatening interaction when taken with {v} Methotrexate
Clotrimazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Clotrimazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Clotrimazole (Compound) causes Cystitis (Side Effect) and Cystitis (Side Effect) is caused by Methotrexate (Compound)
Clotrimazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Methotrexate (Compound)
Clotrimazole (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Tetrahydrofolic acid (Compound) and Tetrahydrofolic acid (Compound) resembles Methotrexate (Compound)
Clotrimazole (Compound) causes Cystitis (Side Effect) and Cystitis (Side Effect) is caused by Lamotrigine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Clotrimazole (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Raltitrexed (Compound) and Raltitrexed (Compound) resembles Methotrexate (Compound)
Clotrimazole (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Amphotericin B (Compound) and Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Clotrimazole (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Hydroxychloroquine (Compound) and Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) resembles Phenylbutazone (Compound) and Phenylbutazone may lead to a major life threatening interaction when taken with Methotrexate
Clotrimazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is downregulated by colon cancer (Disease) and ABCB1 (Disease) associated with colon cancer (Gene) and colon cancer (Disease) is treated by Methotrexate (Compound)