DDInter223 DDInter1853
Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Bosentan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tretinoin
Bosentan {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Bosentan {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Bosentan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Bosentan {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bosentan {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bosentan {u} (Compound) binds {v} (Gene) EDNRB
EDNRB {u} (Gene) regulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Bosentan {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) interacts with {v} (Gene) PSMB10
PSMB10 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Bosentan {u} (Compound) binds {v} (Gene) EDNRB
EDNRB {u} (Gene) regulates {v} (Gene) GOLT1B
GOLT1B {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Bosentan {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is regulated by {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tretinoin (Compound)
Bosentan (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Tretinoin (Compound)
Bosentan (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Tretinoin (Compound)
Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Bosentan (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Bosentan (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Bosentan (Compound) binds EDNRB (Gene) and EDNRB (Gene) regulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Tretinoin (Compound)
Bosentan (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) interacts with PSMB10 (Gene) and PSMB10 (Gene) is upregulated by Tretinoin (Compound)
Bosentan (Compound) binds EDNRB (Gene) and EDNRB (Gene) regulates GOLT1B (Gene) and GOLT1B (Gene) is downregulated by Tretinoin (Compound)
Bosentan (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is regulated by RRP8 (Gene) and RRP8 (Gene) is upregulated by Tretinoin (Compound)