DDInter298 DDInter809
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Capecitabine
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Dactinomycin
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Carboplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gatifloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Procarbazine
Procarbazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Gatifloxacin (Compound)
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gatifloxacin (Compound)
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Gatifloxacin
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with XBP1 (Gene) and XBP1 (Gene) is downregulated by Gatifloxacin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Capecitabine (Compound) and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Dactinomycin (Compound) and Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Carboplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) is treated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Gatifloxacin
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Procarbazine (Compound) and Procarbazine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin