DDInter1666 DDInter65
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Sildenafil {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Amifostine
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Sildenafil {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Sildenafil {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Amifostine
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Amifostine
Sildenafil {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Sildenafil {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Amifostine
Sildenafil {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Amifostine
Sildenafil {u} (Compound) downregulates {v} (Gene) BASP1
BASP1 {u} (Gene) is regulated by {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Amifostine
Sildenafil {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Captopril
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Sildenafil (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Sildenafil (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Sildenafil (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Amifostine (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Sildenafil (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Sildenafil (Compound) downregulates CYCS (Gene) and CYCS (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Amifostine (Compound)
Sildenafil (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Amifostine (Compound)
Sildenafil (Compound) downregulates BASP1 (Gene) and BASP1 (Gene) is regulated by PUF60 (Gene) and PUF60 (Gene) is downregulated by Amifostine (Compound)
Sildenafil (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Captopril (Compound) and Captopril may cause a moderate interaction that could exacerbate diseases when taken with Amifostine