DDInter742 DDInter150
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Floxuridine {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Floxuridine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Floxuridine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Floxuridine {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is regulated by {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Floxuridine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Floxuridine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Floxuridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Tioguanine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Azathioprine
Floxuridine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Floxuridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Tioguanine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Floxuridine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Floxuridine (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is upregulated by Azathioprine (Compound)
Floxuridine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Floxuridine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Azathioprine (Compound)
Floxuridine (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is regulated by HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Azathioprine (Compound)
Floxuridine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Floxuridine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Azathioprine (Compound)
Floxuridine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Floxuridine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)