DDInter458 DDInter551
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Niclosamide
Niclosamide {u} (Compound) resembles {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) regulates {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Diflunisal
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Diflunisal
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Diflunisal (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Diflunisal (Compound)
Cyclosporine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Diflunisal (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is downregulated by Diflunisal (Compound)
Cyclosporine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diflunisal (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Salicylic acid (Compound) and Salicylic acid (Compound) resembles Diflunisal (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Salsalate (Compound) and Salsalate (Compound) resembles Diflunisal (Compound)
Cyclosporine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Niclosamide (Compound) and Niclosamide (Compound) resembles Diflunisal (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) regulates TYMS (Gene) and TYMS (Gene) is downregulated by Diflunisal (Compound)
Cyclosporine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Salicylic acid (Compound) and Salicylic acid (Compound) resembles Diflunisal (Compound)