DDInter1042 DDInter1532
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
Promazine {u} (Compound) resembles {v} (Compound) Propiomazine
Promazine {u} (Compound) resembles {v} (Compound) Ethopropazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Promazine {u} (Compound) binds {v} (Gene) ADRA2A
Promazine {u} (Compound) upregulates {v} (Gene) EBP
Promazine {u} (Compound) downregulates {v} (Gene) EZH2
Promazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Promazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium carbonate
Promazine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Promazine (Compound) resembles Propiomazine (Compound)
Promazine (Compound) resembles Ethopropazine (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Promazine (Compound) binds ADRA2A (Gene)
Promazine (Compound) upregulates EBP (Gene)
Promazine (Compound) downregulates EZH2 (Gene)
Promazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Promazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Promazine may lead to a major life threatening interaction when taken with Bupropion