DDInter75 DDInter1840
An antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Aminosalicylic acid {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Levodopa
Levodopa {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Levodopa
Levodopa {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Droxidopa
Droxidopa {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) binds {v} (Gene) CHUK
CHUK {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) upregulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Aminosalicylic acid {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Aminosalicylic acid (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Aminosalicylic acid (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Trabectedin (Compound)
Aminosalicylic acid (Compound) resembles Levodopa (Compound) and Levodopa (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trabectedin (Compound)
Aminosalicylic acid (Compound) resembles Levodopa (Compound) and Levodopa (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Trabectedin (Compound)
Aminosalicylic acid (Compound) resembles Droxidopa (Compound) and Droxidopa (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Trabectedin (Compound)
Aminosalicylic acid (Compound) binds CHUK (Gene) and CHUK (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Aminosalicylic acid (Compound) upregulates NFKB2 (Gene) and NFKB2 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Aminosalicylic acid (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)