DDInter458 DDInter702
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) downregulates {v} (Gene) LIG1
LIG1 {u} (Gene) is upregulated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) downregulates {v} (Gene) AURKB
AURKB {u} (Gene) is downregulated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CALU
CALU {u} (Gene) is downregulated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is upregulated by {v} (Disease) lung cancer
lung cancer {u} (Disease) is treated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) regulates {v} (Gene) LIG1
LIG1 {u} (Gene) is upregulated by {v} (Compound) Etoposide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is associated with {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is treated by {v} (Compound) Etoposide
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Etoposide (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Etoposide (Compound)
Cyclosporine (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is upregulated by Etoposide (Compound)
Cyclosporine (Compound) downregulates AURKB (Gene) and AURKB (Gene) is downregulated by Etoposide (Compound)
Cyclosporine (Compound) upregulates CALU (Gene) and CALU (Gene) is downregulated by Etoposide (Compound)
Cyclosporine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Etoposide (Compound)
Cyclosporine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Etoposide (Compound) and TOP2A (Gene) is downregulated by Etoposide (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is upregulated by lung cancer (Disease) and lung cancer (Disease) is treated by Etoposide (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) regulates LIG1 (Gene) and LIG1 (Gene) is upregulated by Etoposide (Compound)
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is associated with prostate cancer (Disease) and prostate cancer (Disease) is treated by Etoposide (Compound)