DDInter1886 DDInter1834
Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevus Pharmaceutical Inc._ and was granted FDA approval in 2007.
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Trospium {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Topiramate
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Mepenzolate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Topiramate
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipratropium
Ipratropium {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Topiramate
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Mepenzolate {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Topiramate
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aclidinium
Aclidinium {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Topiramate
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipratropium
Ipratropium {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Topiramate
Trospium {u} (Compound) resembles {v} (Compound) Diphenylpyraline
Diphenylpyraline {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Topiramate
Trospium {u} (Compound) binds {v} (Gene) CHRM3
CHRM3 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Topiramate
Trospium {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Topiramate
Trospium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polythiazide
Polythiazide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Topiramate
Trospium (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Topiramate (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Topiramate (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Ipratropium and Ipratropium (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Topiramate (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Topiramate (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium and Aclidinium (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Topiramate (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Ipratropium and Ipratropium (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Topiramate (Compound)
Trospium (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Topiramate (Compound)
Trospium (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Topiramate (Compound)
Trospium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Topiramate (Compound)
Trospium may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Topiramate (Compound)