DDInter576 DDInter76
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) causes {v} (Side Effect) Erectile dysfunction
Erectile dysfunction {u} (Side Effect) is caused by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dronedarone
Dronedarone {u} (Compound) resembles {v} (Compound) Amiodarone
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiodarone
Disulfiram {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) regulates {v} (Gene) SQRDL
SQRDL {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Disulfiram {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is regulated by {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Amiodarone (Compound)
Disulfiram (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Amiodarone (Compound)
Disulfiram (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Amiodarone (Compound)
Disulfiram (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Amiodarone (Compound)
Disulfiram (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Amiodarone (Compound)
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates GNPDA1 (Gene) and GNPDA1 (Gene) is upregulated by Amiodarone (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound) and Dronedarone (Compound) resembles Amiodarone (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone
Disulfiram (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) regulates SQRDL (Gene) and SQRDL (Gene) is upregulated by Amiodarone (Compound)
Disulfiram (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is regulated by ALDOC (Gene) and ALDOC (Gene) is upregulated by Amiodarone (Compound)