DDInter716 DDInter1676
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Felodipine {u} (Compound) resembles {v} (Compound) Amlodipine
Felodipine {u} (Compound) resembles {v} (Compound) Isradipine
Felodipine {u} (Compound) treats {v} (Disease) hypertension
Felodipine {u} (Compound) binds {v} (Gene) CACNA1S
Felodipine {u} (Compound) upregulates {v} (Gene) CGRRF1
Felodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Felodipine {u} (Compound) downregulates {v} (Gene) GJA1
Felodipine {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Felodipine (Compound) resembles Amlodipine (Compound)
Felodipine (Compound) resembles Isradipine (Compound)
Felodipine (Compound) treats hypertension (Disease)
Felodipine (Compound) binds CACNA1S (Gene)
Felodipine (Compound) upregulates CGRRF1 (Gene)
Felodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Felodipine (Compound) downregulates GJA1 (Gene)
Felodipine (Compound) causes Sexual dysfunction (Side Effect)
Felodipine may cause a minor interaction that can limit clinical effects when taken with Theophylline
Felodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor