DDInter781 DDInter902
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B<sub>2</sub> receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B<sub>2</sub> receptors antagonists, thus representing a new class of medication.[A4017,A263041] It was investigated as a potential treatment of hereditary angioedema (HAE) as bradykinin was implicated in HAE swelling; specifically, mice lacking B<sub>2</sub> receptors showed reduced swelling, thus demonstrating bradykinin involvement in the disease pathophysiology.[A4017,A263046] Icatibant was approved by the FDA on August 25, 2011, and by the EMA in 2008 as a treatment for hereditary angioedema.[L49776,L49781] The FDA approval was based on positive results obtained from 3 double-blind, randomized, controlled clinical trials known as FAST 1, 2, and 3, where a median time to almost complete symptom relief was observed to be 8 hours compared to 36 hours for the placebo treatment.
Fosinopril {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Icatibant
Fosinopril {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Goserelin
Goserelin {u} (Compound) resembles {v} (Compound) Icatibant
Fosinopril {u} (Compound) binds {v} (Gene) ACE
ACE {u} (Gene) interacts with {v} (Gene) BDKRB2
BDKRB2 {u} (Gene) is bound by {v} (Compound) Icatibant
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) BDKRB2
BDKRB2 {u} (Gene) is bound by {v} (Compound) Icatibant
Fosinopril {u} (Compound) resembles {v} (Compound) Trandolapril
Trandolapril {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Icatibant
Fosinopril {u} (Compound) resembles {v} (Compound) Cilazapril
Cilazapril {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Icatibant
Fosinopril (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Icatibant (Compound)
Fosinopril (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Goserelin (Compound) and Goserelin (Compound) resembles Icatibant (Compound)
Fosinopril (Compound) binds ACE (Gene) and ACE (Gene) interacts with BDKRB2 (Gene) and BDKRB2 (Gene) is bound by Icatibant (Compound)
Fosinopril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with BDKRB2 (Gene) and BDKRB2 (Gene) is bound by Icatibant (Compound)
Fosinopril (Compound) resembles Trandolapril (Compound) and Trandolapril (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Icatibant (Compound)
Fosinopril (Compound) resembles Cilazapril (Compound) and Cilazapril (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Icatibant (Compound)