DDInter1405 DDInter255
Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti-cancer treatment. Although the risk of developing febrile neutropenia is less than 20% in many readily used chemotherapy regimens, infections pose risks of hospitalization and mortalities. Due to the relatively short circulating half-life of filgrastim, a 20 kDa PEG moiety was covalently conjugated to the N-terminus of filgrastim (at the methionine residue) to develop longer-acting pegfilgrastim.[A29,A187607] Due to a longer half-life and slower elimination rate than filgrastim
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Mercaptopurine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Oxaliplatin {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Mercaptopurine {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ponatinib
Ponatinib {u} (Compound) binds {v} (Gene) FGFR4
FGFR4 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Idarubicin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trifluridine
Trifluridine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trifluridine
Trifluridine {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trifluridine
Trifluridine {u} (Compound) upregulates {v} (Gene) LOXL1
LOXL1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Altretamine
Altretamine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Busulfan
Pegfilgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Arsenic trioxide {u} (Compound) binds {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is bound by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib (Compound) binds FGFR4 (Gene) and FGFR4 (Gene) is upregulated by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) upregulates LOXL1 (Gene) and LOXL1 (Gene) is downregulated by Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Altretamine and Altretamine (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Busulfan (Compound)
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide and Arsenic trioxide (Compound) binds TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Busulfan (Compound)