DDInter1447 DDInter1834
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Phentermine {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Topiramate
Phentermine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Topiramate
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Topiramate
Phentermine {u} (Compound) resembles {v} (Compound) Amphetamine
Amphetamine {u} (Compound) causes {v} (Side Effect) Urinary tract infection
Urinary tract infection {u} (Side Effect) is caused by {v} (Compound) Topiramate
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Pseudoephedrine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Topiramate
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Topiramate
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenylpropanolamine
Phenylpropanolamine {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Topiramate
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenylpropanolamine
Phenylpropanolamine {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Topiramate
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Topiramate
Phentermine {u} (Compound) resembles {v} (Compound) Lacosamide
Lacosamide {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Topiramate
Phentermine (Compound) treats obesity (Disease) and obesity (Disease) is treated by Topiramate (Compound)
Phentermine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Topiramate (Compound)
Phentermine (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Topiramate (Compound)
Phentermine (Compound) resembles Amphetamine (Compound) and Amphetamine (Compound) causes Urinary tract infection (Side Effect) and Urinary tract infection (Side Effect) is caused by Topiramate (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Topiramate (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Topiramate (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenylpropanolamine and Phenylpropanolamine (Compound) treats obesity (Disease) and obesity (Disease) is treated by Topiramate (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenylpropanolamine and Phenylpropanolamine (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Topiramate (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Topiramate (Compound)
Phentermine (Compound) resembles Lacosamide (Compound) and Lacosamide (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Topiramate (Compound)