DDInter1323 DDInter704
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is a life-threatening disease requiring life-long management. Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural hormone, somatostatin, which inhibits the secretion of growth hormone. Additionally, it is used for the treatment of acromegaly and symptoms arising from various tumors, including carcinoid tumors and vasoactive intestinal tumors (VIPomas). In the past, octreotide has been administered solely by injection. On June 26, 2020, the first approved delayed-release oral somatostatin analog, Mycapssa, received FDA approval for the long term maintenance
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Octreotide {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Everolimus
Octreotide {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Octreotide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Octreotide {u} (Compound) resembles {v} (Compound) Polymyxin B
Polymyxin B {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Everolimus
Octreotide {u} (Compound) resembles {v} (Compound) Polymyxin B
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Octreotide {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Octreotide {u} (Compound) treats {v} (Disease) thymus cancer
thymus cancer {u} (Disease) is associated with {v} (Gene) KIT
KIT {u} (Gene) is upregulated by {v} (Compound) Everolimus
Octreotide {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Octreotide {u} (Compound) binds {v} (Gene) SSTR2
SSTR2 {u} (Gene) interacts with {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Octreotide {u} (Compound) binds {v} (Gene) SSTR1
SSTR1 {u} (Gene) interacts with {v} (Gene) PRMT5
PRMT5 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Octreotide (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Everolimus (Compound)
Octreotide (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Octreotide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Octreotide (Compound) resembles Polymyxin B (Compound) and Polymyxin B (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Everolimus (Compound)
Octreotide (Compound) resembles Polymyxin B (Compound) and Polymyxin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Octreotide (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Everolimus (Compound)
Octreotide (Compound) treats thymus cancer (Disease) and thymus cancer (Disease) is associated with KIT (Gene) and KIT (Gene) is upregulated by Everolimus (Compound)
Octreotide (Compound) resembles Bacitracin (Compound) and Bacitracin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Octreotide (Compound) binds SSTR2 (Gene) and SSTR2 (Gene) interacts with GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Everolimus (Compound)
Octreotide (Compound) binds SSTR1 (Gene) and SSTR1 (Gene) interacts with PRMT5 (Gene) and PRMT5 (Gene) is downregulated by Everolimus (Compound)