DDInter856 DDInter1812
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for high affinity binding to antithrombin III (ATIII). This complex greatly accelerates the inhibition of factor Xa. It is an anticoagulant and considered an antithrombotic. Tinzaparin must be given either subcutaneously or parenterally. LMWHs are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Tinzaparin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chamomile
Tinzaparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Tinzaparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vortioxetine
Tinzaparin {u} may lead to a major life threatening interaction when taken with {v} Abciximab
Tinzaparin {u} may lead to a major life threatening interaction when taken with {v} Acalabrutinib
Tinzaparin may cause a minor interaction that can limit clinical effects when taken with Chamomile
Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Tinzaparin may lead to a major life threatening interaction when taken with Abciximab
Tinzaparin may lead to a major life threatening interaction when taken with Acalabrutinib