DDInter1867 DDInter224
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor, [imatinib], was introduced over a decade ago as a breakthrough in CML management; however, emerging resistance to [imatinib] poses challenges in achieving remission. Second-generation BCR-ABL inhibitors like bosutinib inhibit most resistance-conferring BCR-ABL mutations except V299L and T315, thus providing more therapeutic options for patients.[A6901,A17961] Bosutinib was first approved by the FDA in 2012 for the treatment of adult chronic, accelerated, or blast-phase Ph+ CML with resistance or intolerance to prior therapy. On September 26, 2023, bosutinib was also approved by the FDA for the treatment of pediatric CML that is newly diagnosed or resistant/intolerant to prior therapy. This approval was based on favorable results obtained from the open-label, randomized, multicenter trial BFORE that showed a significant improvement in major molecular response, defined as a ≤0.1% BCR ABL ratio on an international scale, with bosutinib treatment.
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) upregulates {v} (Gene) HSD17B7
HSD17B7 {u} (Gene) is upregulated by {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) downregulates {v} (Gene) NME1
NME1 {u} (Gene) is downregulated by {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) resembles {v} (Compound) Alimemazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bosutinib
Triflupromazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Bosutinib
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) upregulates {v} (Gene) HSD17B7
HSD17B7 {u} (Gene) regulates {v} (Gene) IKBKE
IKBKE {u} (Gene) is bound by {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is regulated by {v} (Gene) HCK
HCK {u} (Gene) is bound by {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) upregulates {v} (Gene) FDPS
FDPS {u} (Gene) regulates {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Bosutinib
Triflupromazine {u} (Compound) upregulates {v} (Gene) SQLE
SQLE {u} (Gene) interacts with {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Bosutinib
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Bosutinib (Compound)
Triflupromazine (Compound) upregulates HSD17B7 (Gene) and HSD17B7 (Gene) is upregulated by Bosutinib (Compound)
Triflupromazine (Compound) downregulates NME1 (Gene) and NME1 (Gene) is downregulated by Bosutinib (Compound)
Triflupromazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib
Triflupromazine (Compound) resembles Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Bosutinib
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Gefitinib (Compound) and Gefitinib (Compound) resembles Bosutinib (Compound)
Triflupromazine (Compound) upregulates HSD17B7 (Gene) and HSD17B7 (Gene) regulates IKBKE (Gene) and IKBKE (Gene) is bound by Bosutinib (Compound)
Triflupromazine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is regulated by HCK (Gene) and HCK (Gene) is bound by Bosutinib (Compound)
Triflupromazine (Compound) upregulates FDPS (Gene) and FDPS (Gene) regulates GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Bosutinib (Compound)
Triflupromazine (Compound) upregulates SQLE (Gene) and SQLE (Gene) interacts with ALDOC (Gene) and ALDOC (Gene) is upregulated by Bosutinib (Compound)