DDInter1311 DDInter1376
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Norepinephrine {u} (Compound) resembles {v} (Compound) Methyldopa
Norepinephrine {u} (Compound) resembles {v} (Compound) Epinephrine
Norepinephrine {u} (Compound) binds {v} (Gene) ADRA1D
Norepinephrine {u} (Compound) upregulates {v} (Gene) MCOLN1
Norepinephrine {u} (Compound) is included by {v} (Pharmacologic Class) Catecholamines
Norepinephrine {u} (Compound) causes {v} (Side Effect) Violent
Norepinephrine (Compound) resembles Methyldopa (Compound)
Norepinephrine (Compound) resembles Epinephrine (Compound)
Norepinephrine (Compound) binds ADRA1D (Gene)
Norepinephrine (Compound) upregulates MCOLN1 (Gene)
Norepinephrine (Compound) is included by Catecholamines (Pharmacologic Class)
Norepinephrine (Compound) causes Violent (Side Effect)