DDInter458 DDInter202
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bexarotene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypocholesterolaemia
Hypocholesterolaemia {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Griseofulvin
Griseofulvin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Griseofulvin
Griseofulvin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urinary incontinence
Urinary incontinence {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Carcinoma
Carcinoma {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bexarotene
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Tamibarotene
Tamibarotene {u} (Compound) resembles {v} (Compound) Bexarotene
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) RXRG
RXRG {u} (Gene) is bound by {v} (Compound) Bexarotene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Carcinoma
Carcinoma {u} (Side Effect) is caused by {v} (Compound) Norethisterone
Norethisterone {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Cyclosporine (Compound) causes Hypocholesterolaemia (Side Effect) and Hypocholesterolaemia (Side Effect) is caused by Bexarotene (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Griseofulvin (Compound) and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Cyclosporine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Griseofulvin (Compound) and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Cyclosporine (Compound) causes Urinary incontinence (Side Effect) and Urinary incontinence (Side Effect) is caused by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Cyclosporine (Compound) causes Carcinoma (Side Effect) and Carcinoma (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Tamibarotene (Compound) and Tamibarotene (Compound) resembles Bexarotene (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by RXRG (Gene) and RXRG (Gene) is bound by Bexarotene (Compound)
Cyclosporine (Compound) causes Carcinoma (Side Effect) and Carcinoma (Side Effect) is caused by Norethisterone (Compound) and Norethisterone may lead to a major life threatening interaction when taken with Bexarotene