DDInter1610 DDInter120
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Rivastigmine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Rivastigmine {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) interacts with {v} (Gene) JUN
JUN {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Rivastigmine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Arsenic trioxide
Rivastigmine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) JUN
JUN {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Rivastigmine {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Galantamine
Galantamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Rivastigmine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Rivastigmine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Rivastigmine {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Procainamide
Procainamide {u} may lead to a major life threatening interaction when taken with {v} Arsenic trioxide
Rivastigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Pyridostigmine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Rivastigmine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Rivastigmine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Rivastigmine (Compound) binds ACHE (Gene) and ACHE (Gene) interacts with JUN (Gene) and JUN (Gene) is bound by Arsenic trioxide (Compound)
Rivastigmine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Rivastigmine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by JUN (Gene) and JUN (Gene) is bound by Arsenic trioxide (Compound)
Rivastigmine (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Galantamine (Compound) and Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Rivastigmine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Rivastigmine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Rivastigmine (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Procainamide (Compound) and Procainamide may lead to a major life threatening interaction when taken with Arsenic trioxide
Rivastigmine (Compound) resembles Pyridostigmine (Compound) and Pyridostigmine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Rivastigmine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide