DDInter527 DDInter1397
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Dextromethorphan {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is associated with {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) resembles {v} (Compound) Levorphanol
Levorphanol {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dihydrocodeine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) resembles {v} (Compound) Levorphanol
Levorphanol {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dextromethorphan {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dihydrocodeine {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydromorphone
Hydromorphone {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dextromethorphan (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Paroxetine (Compound)
Dextromethorphan (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Paroxetine (Compound)
Dextromethorphan (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is associated with panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)
Dextromethorphan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Dextromethorphan (Compound) resembles Levorphanol (Compound) and Levorphanol (Compound) downregulates TYMS (Gene) and TYMS (Gene) is downregulated by Paroxetine (Compound)
Dextromethorphan (Compound) resembles Dihydrocodeine (Compound) and Dihydrocodeine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Dextromethorphan (Compound) resembles Levorphanol (Compound) and Levorphanol (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Dextromethorphan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Paroxetine (Compound)
Dextromethorphan (Compound) resembles Dihydrocodeine (Compound) and Dihydrocodeine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Paroxetine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)