DDInter548 DDInter1619
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], . It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome . In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole .
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is downregulated by {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is palliated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) TTR
TTR {u} (Gene) is associated with {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is palliated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR1
ESR1 {u} (Gene) interacts with {v} (Gene) DECR1
DECR1 {u} (Gene) is downregulated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) TTR
TTR {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) upregulates {v} (Gene) GHR
GHR {u} (Gene) is upregulated by {v} (Compound) Ropinirole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR2
ESR2 {u} (Gene) regulates {v} (Gene) IKZF1
IKZF1 {u} (Gene) is upregulated by {v} (Compound) Ropinirole
Diethylstilbestrol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ropinirole (Compound)
Diethylstilbestrol (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Ropinirole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ropinirole (Compound)
Diethylstilbestrol (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Ropinirole (Compound)
Diethylstilbestrol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is downregulated by Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is palliated by Ropinirole (Compound)
Diethylstilbestrol (Compound) binds TTR (Gene) and TTR (Gene) is associated with Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is palliated by Ropinirole (Compound)
Diethylstilbestrol (Compound) binds ESR1 (Gene) and ESR1 (Gene) interacts with DECR1 (Gene) and DECR1 (Gene) is downregulated by Ropinirole (Compound)
Diethylstilbestrol (Compound) binds TTR (Gene) and TTR (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Ropinirole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) upregulates GHR (Gene) and GHR (Gene) is upregulated by Ropinirole (Compound)
Diethylstilbestrol (Compound) binds ESR2 (Gene) and ESR2 (Gene) regulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Ropinirole (Compound)