DDInter908 DDInter1662
Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Iloprost {u} (Compound) resembles {v} (Compound) Bimatoprost
Bimatoprost {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Sertraline
Iloprost {u} (Compound) binds {v} (Gene) PDE4D
PDE4D {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Iloprost {u} (Compound) binds {v} (Gene) PDE4A
PDE4A {u} (Gene) is associated with {v} (Disease) autistic disorder
autistic disorder {u} (Disease) is palliated by {v} (Compound) Sertraline
Iloprost {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Tadalafil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Trandolapril {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Sertraline
Iloprost {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Tadalafil {u} (Compound) causes {v} (Side Effect) Haematuria
Haematuria {u} (Side Effect) is caused by {v} (Compound) Sertraline
Iloprost {u} (Compound) binds {v} (Gene) PLAT
PLAT {u} (Gene) regulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Sertraline
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Sertraline
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolmetin
Tolmetin {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Iloprost (Compound) resembles Bimatoprost (Compound) and Bimatoprost (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Sertraline (Compound)
Iloprost (Compound) binds PDE4D (Gene) and PDE4D (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Sertraline (Compound)
Iloprost (Compound) binds PDE4A (Gene) and PDE4A (Gene) is associated with autistic disorder (Disease) and autistic disorder (Disease) is palliated by Sertraline (Compound)
Iloprost may cause a minor interaction that can limit clinical effects when taken with Tadalafil and Tadalafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Sertraline (Compound)
Iloprost may cause a minor interaction that can limit clinical effects when taken with Tadalafil and Tadalafil (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Sertraline (Compound)
Iloprost (Compound) binds PLAT (Gene) and PLAT (Gene) regulates PCNA (Gene) and PCNA (Gene) is downregulated by Sertraline (Compound)
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Sertraline (Compound)
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)