DDInter458 DDInter1523
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Cyclosporine {u} (Compound) upregulates {v} (Gene) GLRX
GLRX {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) MELK
MELK {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Probucol
Cyclosporine {u} (Compound) upregulates {v} (Gene) GLRX
GLRX {u} (Gene) is upregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) MELK
MELK {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Cyclosporine {u} (Compound) upregulates {v} (Gene) GLRX
GLRX {u} (Gene) is upregulated by {v} (Compound) Crizotinib
Crizotinib {u} may lead to a major life threatening interaction when taken with {v} Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Toremifene
Toremifene {u} may lead to a major life threatening interaction when taken with {v} Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) MELK
MELK {u} (Gene) is upregulated by {v} (Compound) Fluconazole
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Crizotinib
Crizotinib {u} may lead to a major life threatening interaction when taken with {v} Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) STMN1
STMN1 {u} (Gene) is regulated by {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Probucol
Cyclosporine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Bosutinib
Bosutinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Cyclosporine (Compound) upregulates GLRX (Gene) and GLRX (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Probucol (Compound)
Cyclosporine (Compound) downregulates MELK (Gene) and MELK (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Probucol (Compound)
Cyclosporine (Compound) upregulates GLRX (Gene) and GLRX (Gene) is upregulated by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Cyclosporine (Compound) downregulates MELK (Gene) and MELK (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Cyclosporine (Compound) upregulates GLRX (Gene) and GLRX (Gene) is upregulated by Crizotinib (Compound) and Crizotinib may lead to a major life threatening interaction when taken with Probucol
Cyclosporine (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Toremifene (Compound) and Toremifene may lead to a major life threatening interaction when taken with Probucol
Cyclosporine (Compound) downregulates MELK (Gene) and MELK (Gene) is upregulated by Fluconazole (Compound) and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Cyclosporine (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Crizotinib (Compound) and Crizotinib may lead to a major life threatening interaction when taken with Probucol
Cyclosporine (Compound) downregulates STMN1 (Gene) and STMN1 (Gene) is regulated by RRS1 (Gene) and RRS1 (Gene) is upregulated by Probucol (Compound)
Cyclosporine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Bosutinib (Compound) and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Probucol