DDInter416 DDInter722
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily. Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Clotrimazole {u} (Compound) resembles {v} (Compound) Darifenacin
Darifenacin {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Clofedanol
Clofedanol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Darifenacin
Darifenacin {u} (Compound) resembles {v} (Compound) Difenoxin
Difenoxin {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Difenoxin
Difenoxin {u} (Compound) resembles {v} (Compound) Darifenacin
Darifenacin {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Darifenacin
Darifenacin {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fentanyl
Clotrimazole (Compound) resembles Darifenacin (Compound) and Darifenacin (Compound) resembles Fentanyl (Compound)
Clotrimazole (Compound) resembles Loperamide (Compound) and Loperamide (Compound) resembles Fentanyl (Compound)
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) resembles Fentanyl (Compound)
Clotrimazole (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Fentanyl (Compound)
Clotrimazole (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Fentanyl (Compound)
Clotrimazole (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl
Clotrimazole (Compound) resembles Darifenacin (Compound) and Darifenacin (Compound) resembles Difenoxin (Compound) and Difenoxin (Compound) resembles Fentanyl (Compound)
Clotrimazole (Compound) resembles Difenoxin (Compound) and Difenoxin (Compound) resembles Darifenacin (Compound) and Darifenacin (Compound) resembles Fentanyl (Compound)
Clotrimazole (Compound) resembles Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Fentanyl (Compound)
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) resembles Modafinil (Compound) and Modafinil (Compound) resembles Fentanyl (Compound)