DDInter535 DDInter1104
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Diazoxide {u} (Compound) causes {v} (Side Effect) Galactorrhoea
Galactorrhoea {u} (Side Effect) is caused by {v} (Compound) Lurasidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Galactorrhoea
Galactorrhoea {u} (Side Effect) is caused by {v} (Compound) Ziprasidone
Ziprasidone {u} (Compound) resembles {v} (Compound) Lurasidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lurasidone
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Lurasidone
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lurasidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Dabrafenib
Dabrafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lurasidone
Diazoxide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Imatinib
Imatinib {u} may lead to a major life threatening interaction when taken with {v} Lurasidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Lurasidone
Diazoxide {u} (Compound) binds {v} (Gene) ATP1A1
ATP1A1 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lurasidone
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) interacts with {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Lurasidone
Diazoxide (Compound) causes Galactorrhoea (Side Effect) and Galactorrhoea (Side Effect) is caused by Lurasidone (Compound)
Diazoxide (Compound) causes Galactorrhoea (Side Effect) and Galactorrhoea (Side Effect) is caused by Ziprasidone (Compound) and Ziprasidone (Compound) resembles Lurasidone (Compound)
Diazoxide (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Lurasidone (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Diazoxide (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Dabrafenib (Compound) and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Diazoxide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Imatinib (Compound) and Imatinib may lead to a major life threatening interaction when taken with Lurasidone
Diazoxide (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Lurasidone
Diazoxide (Compound) binds ATP1A1 (Gene) and ATP1A1 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) interacts with HTR2A (Gene) and HTR2A (Gene) is bound by Lurasidone (Compound)