DDInter458 DDInter1144
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem cell transplant. It is also used to treat uveal melanoma with unresectable hepatic metastases.
Cyclosporine {u} (Compound) upregulates {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Melphalan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Rhabdomyolysis
Rhabdomyolysis {u} (Side Effect) is caused by {v} (Compound) Melphalan
Cyclosporine {u} (Compound) upregulates {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Rhabdomyolysis
Rhabdomyolysis {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Interstitial lung disease
Interstitial lung disease {u} (Side Effect) is caused by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Levodopa
Levodopa {u} (Compound) resembles {v} (Compound) Melphalan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tingling sensation
Tingling sensation {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Norfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Wound
Wound {u} (Side Effect) is caused by {v} (Compound) Carmustine
Carmustine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Levodopa
Levodopa {u} (Compound) resembles {v} (Compound) Melphalan
Cyclosporine {u} (Compound) upregulates {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Cyclosporine (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Melphalan (Compound)
Cyclosporine (Compound) causes Rhabdomyolysis (Side Effect) and Rhabdomyolysis (Side Effect) is caused by Melphalan (Compound)
Cyclosporine (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Cyclosporine (Compound) causes Rhabdomyolysis (Side Effect) and Rhabdomyolysis (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Melphalan
Cyclosporine (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Cyclosporine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Levodopa (Compound) and Levodopa (Compound) resembles Melphalan (Compound)
Cyclosporine (Compound) causes Tingling sensation (Side Effect) and Tingling sensation (Side Effect) is caused by Norfloxacin (Compound) and Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Melphalan
Cyclosporine (Compound) causes Wound (Side Effect) and Wound (Side Effect) is caused by Carmustine (Compound) and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Levodopa (Compound) and Levodopa (Compound) resembles Melphalan (Compound)
Cyclosporine (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Epirubicin (Compound) and Epirubicin may cause a minor interaction that can limit clinical effects when taken with Melphalan