DDInter1809 DDInter1376
Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Timolol {u} (Compound) resembles {v} (Compound) Levobunolol
Timolol {u} (Compound) treats {v} (Disease) glaucoma
Timolol {u} (Compound) binds {v} (Gene) ADRB1
Timolol {u} (Compound) upregulates {v} (Gene) TCN1
Timolol {u} (Compound) downregulates {v} (Gene) PEG10
Timolol {u} (Compound) causes {v} (Side Effect) Affect lability
Timolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Timolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Liothyronine
Timolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iopodic acid
Timolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gadodiamide
Timolol (Compound) resembles Levobunolol (Compound)
Timolol (Compound) treats glaucoma (Disease)
Timolol (Compound) binds ADRB1 (Gene)
Timolol (Compound) upregulates TCN1 (Gene)
Timolol (Compound) downregulates PEG10 (Gene)
Timolol (Compound) causes Affect lability (Side Effect)
Timolol may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Timolol may cause a minor interaction that can limit clinical effects when taken with Liothyronine
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide