DDInter154 DDInter1442
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Azelastine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Azelastine {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Azelastine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Azelastine {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Azelastine {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Azelastine {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Methsuximide {u} (Compound) resembles {v} (Compound) Phenobarbital
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Azelastine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Secobarbital
Secobarbital {u} (Compound) resembles {v} (Compound) Phenobarbital
Azelastine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Phenobarbital (Compound)
Azelastine (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Phenobarbital (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Azelastine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Primidone (Compound) and Primidone (Compound) resembles Phenobarbital (Compound)
Azelastine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Azelastine (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Phenobarbital (Compound)
Azelastine (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Methsuximide (Compound) and Methsuximide (Compound) resembles Phenobarbital (Compound)
Azelastine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Phenobarbital (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Azelastine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Secobarbital (Compound) and Secobarbital (Compound) resembles Phenobarbital (Compound)