DDInter1259 DDInter255
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Nalidixic acid {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) is regulated by {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) regulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) resembles {v} (Compound) Pefloxacin
Pefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) resembles {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Nalidixic acid {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is regulated by {v} (Gene) NNT
NNT {u} (Gene) is downregulated by {v} (Compound) Busulfan
Nalidixic acid (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) is downregulated by Busulfan (Compound)
Nalidixic acid (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Nalidixic acid (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) is regulated by GSTP1 (Gene) and GSTP1 (Gene) is bound by Busulfan (Compound)
Nalidixic acid (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Nalidixic acid (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) regulates TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Busulfan (Compound)
Nalidixic acid (Compound) resembles Pefloxacin (Compound) and Pefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Nalidixic acid (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Nalidixic acid (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Nalidixic acid (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Nalidixic acid (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is regulated by NNT (Gene) and NNT (Gene) is downregulated by Busulfan (Compound)