DDInter298 DDInter431
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) downregulates {v} (Gene) CLASRP
CLASRP {u} (Gene) is upregulated by {v} (Compound) Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) TPM1
TPM1 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is associated with {v} (Gene) ESR1
ESR1 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) upregulates {v} (Gene) MCM6
MCM6 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) downregulates {v} (Gene) HADH
HADH {u} (Gene) is downregulated by {v} (Compound) Colchicine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) FOSL1
FOSL1 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) upregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) downregulates CLASRP (Gene) and CLASRP (Gene) is upregulated by Colchicine (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Colchicine (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with TPM1 (Gene) and TPM1 (Gene) is upregulated by Colchicine (Compound)
Carboplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is associated with ESR1 (Gene) and ESR1 (Gene) is downregulated by Colchicine (Compound)
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) upregulates MCM6 (Gene) and MCM6 (Gene) is downregulated by Colchicine (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) downregulates HADH (Gene) and HADH (Gene) is downregulated by Colchicine (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates FOSL1 (Gene) and FOSL1 (Gene) is upregulated by Colchicine (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) upregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by Colchicine (Compound)