DDInter170 DDInter832
Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP synthase responsible for synthesizing ATP. Consequently, bedaquiline can be used to treat mycobacterial infection, particularly tuberculosis (TB). Although the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB) to [isoniazid] and [rifampin] has substantially worsened patients outcome. Bedaquiline was approved by the FDA on December 28,
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Bedaquiline {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Bedaquiline {u} (Compound) resembles {v} (Compound) Orphenadrine
Bedaquiline {u} (Compound) binds {v} (Gene) CYP3A4
Bedaquiline {u} (Compound) is included by {v} (Pharmacologic Class) Diarylquinolines
Bedaquiline {u} (Compound) causes {v} (Side Effect) Arrhythmia
Bedaquiline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Bedaquiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dimethyl fumarate
Bedaquiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Bedaquiline {u} may lead to a major life threatening interaction when taken with {v} Clarithromycin
Bedaquiline {u} may lead to a major life threatening interaction when taken with {v} Glasdegib
Bedaquiline (Compound) resembles Bromodiphenhydramine (Compound)
Bedaquiline (Compound) resembles Orphenadrine (Compound)
Bedaquiline (Compound) binds CYP3A4 (Gene)
Bedaquiline (Compound) is included by Diarylquinolines (Pharmacologic Class)
Bedaquiline (Compound) causes Arrhythmia (Side Effect)
Bedaquiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Bedaquiline may lead to a major life threatening interaction when taken with Clarithromycin
Bedaquiline may lead to a major life threatening interaction when taken with Glasdegib