DDInter1253 DDInter1960
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as active as Δ⁹-THC. Nabilone is approved by the FDA for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction with cannabinoid receptors that are
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Nabilone {u} (Compound) resembles {v} (Compound) Dronabinol
Nabilone {u} (Compound) binds {v} (Gene) CNR2
Nabilone {u} (Compound) is included by {v} (Pharmacologic Class) Cannabinoids
Nabilone {u} (Compound) causes {v} (Side Effect) Lightheadedness
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Nabilone {u} may lead to a major life threatening interaction when taken with {v} Levacetylmethadol
Nabilone (Compound) resembles Dronabinol (Compound)
Nabilone (Compound) binds CNR2 (Gene)
Nabilone (Compound) is included by Cannabinoids (Pharmacologic Class)
Nabilone (Compound) causes Lightheadedness (Side Effect)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Nabilone may lead to a major life threatening interaction when taken with Levacetylmethadol