DDInter1330 DDInter856
Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. Overall, olmesartan's physiologic effects lead to reduced blood pressure, lower aldosterone levels, reduced cardiac activity, and increased excretion of sodium. Olmesartan also affects the renin-angiotensin aldosterone system (RAAS), which plays an important role in hemostasis and regulation of kidney, vascular, and cardiac functions. Pharmacological blockade of RAAS
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Olmesartan {u} (Compound) resembles {v} (Compound) Forasartan
Olmesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Olmesartan {u} (Compound) treats {v} (Disease) hypertension
Olmesartan {u} (Compound) binds {v} (Gene) AGTR1
Olmesartan {u} (Compound) causes {v} (Side Effect) Arthralgia
Olmesartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Olmesartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Olmesartan {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Olmesartan (Compound) resembles Forasartan (Compound)
Olmesartan (Compound) resembles Telmisartan (Compound)
Olmesartan (Compound) treats hypertension (Disease)
Olmesartan (Compound) binds AGTR1 (Gene)
Olmesartan (Compound) causes Arthralgia (Side Effect)
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone
Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro
Olmesartan may lead to a major life threatening interaction when taken with Potassium chloride