DDInter757 DDInter178
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Fluorouracil {u} (Compound) resembles {v} (Compound) Uracil mustard
Fluorouracil {u} (Compound) treats {v} (Disease) head and neck cancer
Fluorouracil {u} (Compound) binds {v} (Gene) CYP2C8
Fluorouracil {u} (Compound) upregulates {v} (Gene) SERPINA3
Fluorouracil {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Fluorouracil {u} (Compound) downregulates {v} (Gene) PTPRO
Fluorouracil {u} (Compound) causes {v} (Side Effect) Ventricular septal defect
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Fluorouracil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Temozolomide
Fluorouracil (Compound) resembles Uracil mustard (Compound)
Fluorouracil (Compound) treats head and neck cancer (Disease)
Fluorouracil (Compound) binds CYP2C8 (Gene)
Fluorouracil (Compound) upregulates SERPINA3 (Gene)
Fluorouracil (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Fluorouracil (Compound) downregulates PTPRO (Gene)
Fluorouracil (Compound) causes Ventricular septal defect (Side Effect)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide