DDInter150 DDInter1377
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Azathioprine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) regulates {v} (Gene) ABCC10
ABCC10 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) interacts with {v} (Gene) NR1I2
NR1I2 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Docetaxel
Docetaxel {u} (Compound) resembles {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) regulates {v} (Gene) MMP1
MMP1 {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Azathioprine {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paclitaxel
Azathioprine {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Docetaxel
Docetaxel {u} (Compound) resembles {v} (Compound) Paclitaxel
Azathioprine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Paclitaxel (Compound)
Azathioprine (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Paclitaxel (Compound)
Azathioprine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Paclitaxel (Compound)
Azathioprine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Paclitaxel (Compound)
Azathioprine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) regulates ABCC10 (Gene) and ABCC10 (Gene) is bound by Paclitaxel (Compound)
Azathioprine (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) interacts with NR1I2 (Gene) and NR1I2 (Gene) is bound by Paclitaxel (Compound)
Azathioprine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Docetaxel (Compound) and Docetaxel (Compound) resembles Paclitaxel (Compound)
Azathioprine (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) regulates MMP1 (Gene) and MMP1 (Gene) is upregulated by Paclitaxel (Compound)
Azathioprine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Azathioprine (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Docetaxel (Compound) and Docetaxel (Compound) resembles Paclitaxel (Compound)