DDInter596 DDInter513
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Doxorubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) binds {v} (Gene) NOS2
NOS2 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) downregulates {v} (Gene) ADO
ADO {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) upregulates {v} (Gene) PECR
PECR {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) treats {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is palliated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) downregulates {v} (Gene) AURKB
AURKB {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) CBR3
CBR3 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Doxorubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Doxorubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dexamethasone (Compound)
Doxorubicin (Compound) binds NOS2 (Gene) and NOS2 (Gene) is bound by Dexamethasone (Compound)
Doxorubicin (Compound) downregulates ADO (Gene) and ADO (Gene) is upregulated by Dexamethasone (Compound)
Doxorubicin (Compound) upregulates PECR (Gene) and PECR (Gene) is upregulated by Dexamethasone (Compound)
Doxorubicin (Compound) treats kidney cancer (Disease) and kidney cancer (Disease) is palliated by Dexamethasone (Compound)
Doxorubicin (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is downregulated by Dexamethasone (Compound)
Doxorubicin (Compound) downregulates AURKB (Gene) and AURKB (Gene) is downregulated by Dexamethasone (Compound)
Doxorubicin (Compound) binds CBR3 (Gene) and Doxorubicin (Compound) downregulates CBR3 (Gene) and CBR3 (Gene) is downregulated by Dexamethasone (Compound)
Doxorubicin (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dexamethasone (Compound)
Doxorubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)