DDInter704 DDInter1335
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Everolimus {u} (Compound) upregulates {v} (Gene) SPEN
SPEN {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) downregulates {v} (Gene) B4GAT1
B4GAT1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) binds {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) upregulates {v} (Gene) CCDC85B
CCDC85B {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) resembles {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Everolimus {u} (Compound) upregulates {v} (Gene) SPEN
SPEN {u} (Gene) regulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) upregulates {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is regulated by {v} (Gene) ETS1
ETS1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) upregulates {v} (Gene) CCNL1
CCNL1 {u} (Gene) interacts with {v} (Gene) APPBP2
APPBP2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus {u} (Compound) upregulates {v} (Gene) PPP1R15A
PPP1R15A {u} (Gene) covaries with {v} (Gene) HSPBAP1
HSPBAP1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Everolimus (Compound) upregulates SPEN (Gene) and SPEN (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) downregulates COG4 (Gene) and COG4 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) binds FKBP1A (Gene) and FKBP1A (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) upregulates CCDC85B (Gene) and CCDC85B (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) resembles Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Everolimus (Compound) upregulates SPEN (Gene) and SPEN (Gene) regulates CHIC2 (Gene) and CHIC2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) upregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is regulated by ETS1 (Gene) and ETS1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) upregulates CCNL1 (Gene) and CCNL1 (Gene) interacts with APPBP2 (Gene) and APPBP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Everolimus (Compound) upregulates PPP1R15A (Gene) and PPP1R15A (Gene) covaries with HSPBAP1 (Gene) and HSPBAP1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)