DDInter1826 DDInter856
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Tolazamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolazamide {u} (Compound) treats {v} (Disease) type 2 diabetes mellitus
Tolazamide {u} (Compound) binds {v} (Gene) KCNJ1
Tolazamide {u} (Compound) upregulates {v} (Gene) TSC22D3
Tolazamide {u} (Compound) is included by {v} (Pharmacologic Class) Sulfonylurea Compounds
Tolazamide {u} (Compound) downregulates {v} (Gene) GDF15
Tolazamide {u} (Compound) causes {v} (Side Effect) Headache
Tolazamide (Compound) resembles Tolbutamide (Compound)
Tolazamide (Compound) treats type 2 diabetes mellitus (Disease)
Tolazamide (Compound) binds KCNJ1 (Gene)
Tolazamide (Compound) upregulates TSC22D3 (Gene)
Tolazamide (Compound) is included by Sulfonylurea Compounds (Pharmacologic Class)
Tolazamide (Compound) downregulates GDF15 (Gene)
Tolazamide (Compound) causes Headache (Side Effect)