DDInter1841 DDInter1676
Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and norepinpehrine which activate descending pain inhibitory pathways. Tramadol's effects on serotonin and norepinephrine mimic the effects of other SNRI antidepressants such as [dul
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Tramadol {u} (Compound) resembles {v} (Compound) Venlafaxine
Tramadol {u} (Compound) resembles {v} (Compound) Dextromethorphan
Tramadol {u} (Compound) binds {v} (Gene) SLC6A4
Tramadol {u} (Compound) upregulates {v} (Gene) DNMT1
Tramadol {u} (Compound) palliates {v} (Disease) restless legs syndrome
Tramadol {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Tramadol {u} (Compound) downregulates {v} (Gene) POLR2I
Tramadol {u} (Compound) causes {v} (Side Effect) Asthma
Tramadol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Tramadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Tramadol (Compound) resembles Venlafaxine (Compound)
Tramadol (Compound) resembles Dextromethorphan (Compound)
Tramadol (Compound) binds SLC6A4 (Gene)
Tramadol (Compound) upregulates DNMT1 (Gene)
Tramadol (Compound) palliates restless legs syndrome (Disease)
Tramadol (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Tramadol (Compound) downregulates POLR2I (Gene)
Tramadol (Compound) causes Asthma (Side Effect)
Tramadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline