DDInter720 DDInter1376
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Fenoldopam {u} (Compound) treats {v} (Disease) hypertension
Fenoldopam {u} (Compound) binds {v} (Gene) ADRA2C
Fenoldopam {u} (Compound) upregulates {v} (Gene) SPP1
Fenoldopam {u} (Compound) downregulates {v} (Gene) CEBPB
Fenoldopam {u} (Compound) causes {v} (Side Effect) Creatinine increased
Fenoldopam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentolamine
Fenoldopam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Fenoldopam {u} may lead to a major life threatening interaction when taken with {v} Arsenic trioxide
Fenoldopam (Compound) treats hypertension (Disease)
Fenoldopam (Compound) binds ADRA2C (Gene)
Fenoldopam (Compound) upregulates SPP1 (Gene)
Fenoldopam (Compound) downregulates CEBPB (Gene)
Fenoldopam (Compound) causes Creatinine increased (Side Effect)
Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine
Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Fenoldopam may lead to a major life threatening interaction when taken with Arsenic trioxide