DDInter1607 DDInter427
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Cocaine
Ritonavir {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Cocaine
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Voriconazole
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cocaine
Ritonavir {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} (Compound) resembles {v} (Compound) Cocaine
Ritonavir {u} (Compound) causes {v} (Side Effect) Grand mal convulsion
Grand mal convulsion {u} (Side Effect) is caused by {v} (Compound) Voriconazole
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cocaine
Ritonavir {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Mepivacaine
Mepivacaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cocaine
Ritonavir {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Atropine
Atropine {u} (Compound) resembles {v} (Compound) Cocaine
Ritonavir {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Phenobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cocaine
Ritonavir {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) is downregulated by {v} (Compound) Atropine
Atropine {u} (Compound) resembles {v} (Compound) Cocaine
Ritonavir {u} (Compound) causes {v} (Side Effect) Grand mal convulsion
Grand mal convulsion {u} (Side Effect) is caused by {v} (Compound) Dexmethylphenidate
Dexmethylphenidate {u} may lead to a major life threatening interaction when taken with {v} Cocaine
Ritonavir (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cocaine (Compound)
Ritonavir (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Compound)
Ritonavir (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Voriconazole (Compound) and Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Ritonavir (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Atropine (Compound) and Atropine (Compound) resembles Cocaine (Compound)
Ritonavir (Compound) causes Grand mal convulsion (Side Effect) and Grand mal convulsion (Side Effect) is caused by Voriconazole (Compound) and Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Ritonavir (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Mepivacaine (Compound) and Mepivacaine may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Ritonavir (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Atropine (Compound) and Atropine (Compound) resembles Cocaine (Compound)
Ritonavir (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Phenobarbital (Compound) and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Ritonavir (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Atropine (Compound) and Atropine (Compound) resembles Cocaine (Compound)
Ritonavir (Compound) causes Grand mal convulsion (Side Effect) and Grand mal convulsion (Side Effect) is caused by Dexmethylphenidate (Compound) and Dexmethylphenidate may lead to a major life threatening interaction when taken with Cocaine