DDInter458 DDInter554
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digitalis_ plant, studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is downregulated by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is downregulated by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Digitoxin
Digitoxin {u} (Compound) resembles {v} (Compound) Digoxin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) interacts with {v} (Gene) NR4A1
NR4A1 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Ouabain
Ouabain {u} (Compound) resembles {v} (Compound) Digoxin
Cyclosporine {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) is upregulated by {v} (Compound) Ouabain
Ouabain {u} (Compound) resembles {v} (Compound) Digoxin
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Digoxin (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Digoxin (Compound)
Cyclosporine (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Digoxin (Compound)
Cyclosporine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is downregulated by Digoxin (Compound)
Cyclosporine (Compound) downregulates SPR (Gene) and SPR (Gene) is downregulated by Digoxin (Compound)
Cyclosporine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Digoxin (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Digitoxin (Compound) and Digitoxin (Compound) resembles Digoxin (Compound)
Cyclosporine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) interacts with NR4A1 (Gene) and NR4A1 (Gene) is upregulated by Digoxin (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Ouabain (Compound) and Ouabain (Compound) resembles Digoxin (Compound)
Cyclosporine (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Ouabain (Compound) and Ouabain (Compound) resembles Digoxin (Compound)