DDInter1041 DDInter1627
Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. Despite this difference in activity, the two commercially available forms have been shown to be pharmacokinetically identical and may be used interchangeably with limited differences in efficacy or side effects (Kovoor et al, 2009). As folate analogs, leucovor
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Leucovorin {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Leucovorin {u} (Compound) resembles {v} (Compound) Raltitrexed
Raltitrexed {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Leucovorin {u} (Compound) resembles {v} (Compound) Folic acid
Folic acid {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Leucovorin {u} (Compound) resembles {v} (Compound) Pemetrexed
Pemetrexed {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Leucovorin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Leucovorin {u} (Compound) binds {v} (Gene) TYMS
TYMS {u} (Gene) is regulated by {v} (Gene) SCN9A
SCN9A {u} (Gene) is bound by {v} (Compound) Rufinamide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Fosphenytoin {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lamotrigine
Lamotrigine {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Fosphenytoin {u} (Compound) binds {v} (Gene) SCN5A
SCN5A {u} (Gene) is bound by {v} (Compound) Rufinamide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lamotrigine
Lamotrigine {u} (Compound) binds {v} (Gene) SCN2A
SCN2A {u} (Gene) is bound by {v} (Compound) Rufinamide
Leucovorin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Leucovorin (Compound) resembles Raltitrexed (Compound) and Raltitrexed (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Rufinamide (Compound)
Leucovorin (Compound) resembles Folic acid (Compound) and Folic acid (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Rufinamide (Compound)
Leucovorin (Compound) resembles Pemetrexed (Compound) and Pemetrexed (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Rufinamide (Compound)
Leucovorin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Leucovorin (Compound) binds TYMS (Gene) and TYMS (Gene) is regulated by SCN9A (Gene) and SCN9A (Gene) is bound by Rufinamide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Lamotrigine and Lamotrigine (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin (Compound) binds SCN5A (Gene) and SCN5A (Gene) is bound by Rufinamide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Lamotrigine and Lamotrigine (Compound) binds SCN2A (Gene) and SCN2A (Gene) is bound by Rufinamide (Compound)