DDInter79 DDInter1376
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers. Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Amlodipine {u} (Compound) resembles {v} (Compound) Nilvadipine
Amlodipine {u} (Compound) resembles {v} (Compound) Isradipine
Amlodipine {u} (Compound) treats {v} (Disease) hypertension
Amlodipine {u} (Compound) binds {v} (Gene) CACNA1B
Amlodipine {u} (Compound) upregulates {v} (Gene) ACLY
Amlodipine {u} (Compound) palliates {v} (Disease) coronary artery disease
Amlodipine {u} (Compound) is included by {v} (Pharmacologic Class) Dihydropyridines
Amlodipine {u} (Compound) downregulates {v} (Gene) NOLC1
Amlodipine {u} (Compound) causes {v} (Side Effect) Weight increased
Amlodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Amlodipine (Compound) resembles Nilvadipine (Compound)
Amlodipine (Compound) resembles Isradipine (Compound)
Amlodipine (Compound) treats hypertension (Disease)
Amlodipine (Compound) binds CACNA1B (Gene)
Amlodipine (Compound) upregulates ACLY (Gene)
Amlodipine (Compound) palliates coronary artery disease (Disease)
Amlodipine (Compound) is included by Dihydropyridines (Pharmacologic Class)
Amlodipine (Compound) downregulates NOLC1 (Gene)
Amlodipine (Compound) causes Weight increased (Side Effect)
Amlodipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide