DDInter535 DDInter1572
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Diazoxide {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Rasagiline
Diazoxide {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Diazoxide {u} (Compound) causes {v} (Side Effect) Ageusia
Ageusia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may lead to a major life threatening interaction when taken with {v} Rasagiline
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Rasagiline
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Diazoxide {u} (Compound) upregulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is regulated by {v} (Gene) BCL2
BCL2 {u} (Gene) is bound by {v} (Compound) Rasagiline
Diazoxide {u} (Compound) upregulates {v} (Gene) RBM6
RBM6 {u} (Gene) is upregulated by {v} (Compound) Vemurafenib
Vemurafenib {u} may lead to a major life threatening interaction when taken with {v} Rasagiline
Diazoxide {u} (Compound) upregulates {v} (Gene) DDX42
DDX42 {u} (Gene) is downregulated by {v} (Compound) Anagrelide
Anagrelide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Diazoxide {u} (Compound) upregulates {v} (Gene) CASP2
CASP2 {u} (Gene) interacts with {v} (Gene) BCL2
BCL2 {u} (Gene) is bound by {v} (Compound) Rasagiline
Diazoxide {u} (Compound) upregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Diazoxide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Diazoxide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Diazoxide (Compound) causes Ageusia (Side Effect) and Ageusia (Side Effect) is caused by Doxepin (Compound) and Doxepin may lead to a major life threatening interaction when taken with Rasagiline
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Rasagiline (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Diazoxide (Compound) upregulates PRKCQ (Gene) and PRKCQ (Gene) is regulated by BCL2 (Gene) and BCL2 (Gene) is bound by Rasagiline (Compound)
Diazoxide (Compound) upregulates RBM6 (Gene) and RBM6 (Gene) is upregulated by Vemurafenib (Compound) and Vemurafenib may lead to a major life threatening interaction when taken with Rasagiline
Diazoxide (Compound) upregulates DDX42 (Gene) and DDX42 (Gene) is downregulated by Anagrelide (Compound) and Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Diazoxide (Compound) upregulates CASP2 (Gene) and CASP2 (Gene) interacts with BCL2 (Gene) and BCL2 (Gene) is bound by Rasagiline (Compound)
Diazoxide (Compound) upregulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline