DDInter1397 DDInter393
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) causes {v} (Side Effect) Gingival bleeding
Gingival bleeding {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Troleandomycin
Troleandomycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Dirithromycin
Dirithromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) downregulates {v} (Gene) MIF
MIF {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Erythromycin
Erythromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) downregulates {v} (Gene) DNTTIP2
DNTTIP2 {u} (Gene) regulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) downregulates {v} (Gene) RUVBL1
RUVBL1 {u} (Gene) is regulated by {v} (Gene) PACSIN3
PACSIN3 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Paroxetine {u} (Compound) causes {v} (Side Effect) Gingival bleeding
Gingival bleeding {u} (Side Effect) is caused by {v} (Compound) Indinavir
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Paroxetine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Clarithromycin (Compound)
Paroxetine (Compound) causes Gingival bleeding (Side Effect) and Gingival bleeding (Side Effect) is caused by Clarithromycin (Compound)
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Troleandomycin (Compound) and Troleandomycin (Compound) resembles Clarithromycin (Compound)
Paroxetine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Dirithromycin (Compound) and Dirithromycin (Compound) resembles Clarithromycin (Compound)
Paroxetine (Compound) downregulates MIF (Gene) and MIF (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Paroxetine (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Erythromycin (Compound) and Erythromycin (Compound) resembles Clarithromycin (Compound)
Paroxetine (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) regulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Clarithromycin (Compound)
Paroxetine (Compound) downregulates RUVBL1 (Gene) and RUVBL1 (Gene) is regulated by PACSIN3 (Gene) and PACSIN3 (Gene) is upregulated by Clarithromycin (Compound)
Paroxetine (Compound) causes Gingival bleeding (Side Effect) and Gingival bleeding (Side Effect) is caused by Indinavir (Compound) and Indinavir may cause a minor interaction that can limit clinical effects when taken with Clarithromycin