DDInter6 DDInter856
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Abciximab {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capsicum
Abciximab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Abciximab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Collagenase clostridium histolyticum
Abciximab {u} may lead to a major life threatening interaction when taken with {v} Tinzaparin
Abciximab {u} may lead to a major life threatening interaction when taken with {v} Reteplase
Abciximab may cause a minor interaction that can limit clinical effects when taken with Capsicum
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Collagenase clostridium histolyticum
Abciximab may lead to a major life threatening interaction when taken with Tinzaparin
Abciximab may lead to a major life threatening interaction when taken with Reteplase