DDInter1088 DDInter1798
Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxylate] and [haloperidol]. Due to pharmacological properties, loperamide has been misused and abused to self-manage opioid withdrawal symptoms and to induce euphoria.[A251610, A251625] However, loperamide is associated with a risk for experiencing a range of adverse effects, often life-threatening, if taking for non-therapeutic reasons or at doses higher than the recommended dose.
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Thiothixene
Loperamide {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Thiothixene
Loperamide {u} (Compound) upregulates {v} (Gene) HSD17B7
HSD17B7 {u} (Gene) is upregulated by {v} (Compound) Thiothixene
Loperamide {u} (Compound) downregulates {v} (Gene) PDHX
PDHX {u} (Gene) is downregulated by {v} (Compound) Thiothixene
Loperamide {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Olopatadine
Olopatadine {u} (Compound) resembles {v} (Compound) Thiothixene
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Thiothixene (Compound)
Loperamide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Thiothixene (Compound)
Loperamide (Compound) upregulates HSD17B7 (Gene) and HSD17B7 (Gene) is upregulated by Thiothixene (Compound)
Loperamide (Compound) downregulates PDHX (Gene) and PDHX (Gene) is downregulated by Thiothixene (Compound)
Loperamide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Thiothixene (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Olopatadine (Compound) and Olopatadine (Compound) resembles Thiothixene (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Doxepin (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)