DDInter1834 DDInter896
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553] Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Hyoscyamine
Topiramate {u} (Compound) causes {v} (Side Effect) Angle closure glaucoma
Angle closure glaucoma {u} (Side Effect) is caused by {v} (Compound) Hyoscyamine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Atropine
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Topiramate {u} (Compound) causes {v} (Side Effect) Angle closure glaucoma
Angle closure glaucoma {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Topiramate {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Dolasetron {u} (Compound) resembles {v} (Compound) Hyoscyamine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dolasetron
Dolasetron {u} (Compound) resembles {v} (Compound) Hyoscyamine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Hyoscyamine
Topiramate {u} (Compound) causes {v} (Side Effect) Gastrooesophageal reflux disease
Gastrooesophageal reflux disease {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyoscyamine
Topiramate {u} (Compound) causes {v} (Side Effect) Visual acuity reduced
Visual acuity reduced {u} (Side Effect) is caused by {v} (Compound) Tramadol
Tramadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Topiramate {u} (Compound) causes {v} (Side Effect) Rash maculo-papular
Rash maculo-papular {u} (Side Effect) is caused by {v} (Compound) Digoxin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyoscyamine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Hyoscyamine (Compound)
Topiramate (Compound) causes Angle closure glaucoma (Side Effect) and Angle closure glaucoma (Side Effect) is caused by Hyoscyamine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Atropine (Compound) and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Topiramate (Compound) causes Angle closure glaucoma (Side Effect) and Angle closure glaucoma (Side Effect) is caused by Atropine (Compound) and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Topiramate (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Dolasetron (Compound) and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dolasetron (Compound) and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Hyoscyamine (Compound)
Topiramate (Compound) causes Gastrooesophageal reflux disease (Side Effect) and Gastrooesophageal reflux disease (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine
Topiramate (Compound) causes Visual acuity reduced (Side Effect) and Visual acuity reduced (Side Effect) is caused by Tramadol (Compound) and Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Topiramate (Compound) causes Rash maculo-papular (Side Effect) and Rash maculo-papular (Side Effect) is caused by Digoxin (Compound) and Digoxin may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine