DDInter1098 DDInter416
Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers . The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot .
Lovastatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Sulfinpyrazone {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Peginterferon alfa-2a
Peginterferon alfa-2a {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Lovastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Clotrimazole (Compound)
Lovastatin (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Clotrimazole (Compound)
Lovastatin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Clotrimazole (Compound)
Lovastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Lovastatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Sulfinpyrazone (Compound) and Sulfinpyrazone (Compound) resembles Clotrimazole (Compound)
Lovastatin (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Loperamide (Compound) and Loperamide (Compound) resembles Clotrimazole (Compound)
Lovastatin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Lovastatin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Loperamide (Compound) and Loperamide (Compound) resembles Clotrimazole (Compound)
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a minor interaction that can limit clinical effects when taken with Methadone and Methadone (Compound) resembles Clotrimazole (Compound)
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Methadone and Methadone (Compound) resembles Clotrimazole (Compound)