DDInter1042 DDInter192
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).
Bepridil {u} (Compound) resembles {v} (Compound) Diphenidol
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Bepridil {u} (Compound) resembles {v} (Compound) Fentanyl
Bepridil {u} (Compound) treats {v} (Disease) hypertension
Bepridil {u} (Compound) binds {v} (Gene) CACNA1D
Bepridil {u} (Compound) causes {v} (Side Effect) Insomnia
Bepridil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Bepridil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcium glubionate anhydrous
Bepridil {u} may lead to a major life threatening interaction when taken with {v} Eliglustat
Bepridil (Compound) resembles Diphenidol (Compound)
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Bepridil (Compound) resembles Fentanyl (Compound)
Bepridil (Compound) treats hypertension (Disease)
Bepridil (Compound) binds CACNA1D (Gene)
Bepridil (Compound) causes Insomnia (Side Effect)
Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Bepridil may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Bepridil may lead to a major life threatening interaction when taken with Eliglustat