DDInter150 DDInter1385
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
Azathioprine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Pancuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pancuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pancuronium
Azathioprine {u} (Compound) treats {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is associated with {v} (Gene) BCHE
BCHE {u} (Gene) is bound by {v} (Compound) Pancuronium
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Pancuronium
Azathioprine {u} (Compound) treats {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is treated by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pancuronium
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Pancuronium
Azathioprine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is regulated by {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Pancuronium
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pancuronium
Azathioprine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Pancuronium (Compound)
Azathioprine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rocuronium (Compound) and Rocuronium (Compound) resembles Pancuronium (Compound)
Azathioprine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Pancuronium
Azathioprine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium
Azathioprine (Compound) treats multiple sclerosis (Disease) and multiple sclerosis (Disease) is associated with BCHE (Gene) and BCHE (Gene) is bound by Pancuronium (Compound)
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is regulated by NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Pancuronium (Compound)
Azathioprine (Compound) treats multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is regulated by CDC20 (Gene) and CDC20 (Gene) is downregulated by Pancuronium (Compound)
Azathioprine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is regulated by NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Pancuronium (Compound)
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium