DDInter1666 DDInter542
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is regulated by {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) downregulates {v} (Gene) BASP1
BASP1 {u} (Gene) interacts with {v} (Gene) CRYZ
CRYZ {u} (Gene) is bound by {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) VKORC1
VKORC1 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is downregulated by {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is downregulated by {v} (Compound) Dicoumarol
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) regulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Dicoumarol
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dicoumarol (Compound)
Sildenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Dicoumarol (Compound)
Sildenafil (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Sildenafil (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is regulated by NQO1 (Gene) and NQO1 (Gene) is bound by Dicoumarol (Compound)
Sildenafil (Compound) downregulates BASP1 (Gene) and BASP1 (Gene) interacts with CRYZ (Gene) and CRYZ (Gene) is bound by Dicoumarol (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by VKORC1 (Gene) and VKORC1 (Gene) is bound by Dicoumarol (Compound)
Sildenafil (Compound) downregulates CYCS (Gene) and CYCS (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is downregulated by Dicoumarol (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is downregulated by Dicoumarol (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) regulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Dicoumarol (Compound)