DDInter1513 DDInter1376
Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Prednisolone {u} (Compound) resembles {v} (Compound) Fluprednidene Acetate
Prednisolone {u} (Compound) resembles {v} (Compound) Hydrocortamate
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Testosterone
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxymesterone
Prednisolone {u} (Compound) treats {v} (Disease) chronic obstructive pulmonary disease
Prednisolone {u} (Compound) binds {v} (Gene) NR3C1
Prednisolone {u} (Compound) upregulates {v} (Gene) NFKBIA
Prednisolone {u} (Compound) palliates {v} (Disease) idiopathic pulmonary fibrosis
Prednisolone {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Prednisolone {u} (Compound) downregulates {v} (Gene) FHL2
Prednisolone (Compound) resembles Fluprednidene Acetate (Compound)
Prednisolone (Compound) resembles Hydrocortamate (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Testosterone
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone
Prednisolone (Compound) treats chronic obstructive pulmonary disease (Disease)
Prednisolone (Compound) binds NR3C1 (Gene)
Prednisolone (Compound) upregulates NFKBIA (Gene)
Prednisolone (Compound) palliates idiopathic pulmonary fibrosis (Disease)
Prednisolone (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Prednisolone (Compound) downregulates FHL2 (Gene)