DDInter1866 DDInter596
A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Idarubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) upregulates {v} (Gene) DHCR7
DHCR7 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) upregulates {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) binds {v} (Gene) TNNC1
TNNC1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) downregulates {v} (Gene) PSMB10
PSMB10 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Trifluoperazine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubicin (Compound) resembles Doxorubicin (Compound)
Trifluoperazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxorubicin (Compound)
Trifluoperazine (Compound) upregulates DHCR7 (Gene) and DHCR7 (Gene) is bound by Doxorubicin (Compound)
Trifluoperazine (Compound) upregulates SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Doxorubicin (Compound)
Trifluoperazine (Compound) binds TNNC1 (Gene) and TNNC1 (Gene) is upregulated by Doxorubicin (Compound)
Trifluoperazine (Compound) downregulates PSMB10 (Gene) and PSMB10 (Gene) is upregulated by Doxorubicin (Compound)
Trifluoperazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is downregulated by Doxorubicin (Compound)
Trifluoperazine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Doxorubicin (Compound)
Trifluoperazine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Doxorubicin (Compound)