DDInter292 DDInter1544
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Captopril {u} (Compound) resembles {v} (Compound) Enalapril
Captopril {u} (Compound) treats {v} (Disease) coronary artery disease
Captopril {u} (Compound) binds {v} (Gene) MMP2
Captopril {u} (Compound) upregulates {v} (Gene) RELB
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
Captopril {u} (Compound) causes {v} (Side Effect) Diabetic
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium citrate
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darbepoetin alfa
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glulisine
Captopril (Compound) resembles Enalapril (Compound)
Captopril (Compound) treats coronary artery disease (Disease)
Captopril (Compound) binds MMP2 (Gene)
Captopril (Compound) upregulates RELB (Gene)
Captopril (Compound) downregulates NPC1 (Gene)
Captopril (Compound) causes Diabetic (Side Effect)
Captopril may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Captopril may cause a minor interaction that can limit clinical effects when taken with Darbepoetin alfa
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine