DDInter1683 DDInter1658
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Sodium bicarbonate {u} (Compound) resembles {v} (Compound) Acetic acid
Sodium bicarbonate {u} (Compound) binds {v} (Gene) SLC4A10
Sodium bicarbonate {u} (Compound) causes {v} (Side Effect) Metabolic alkalosis
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Sodium bicarbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Demeclocycline
Sodium bicarbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Choline salicylate
Sodium bicarbonate {u} may lead to a major life threatening interaction when taken with {v} Dolutegravir
Sodium bicarbonate (Compound) resembles Acetic acid (Compound)
Sodium bicarbonate (Compound) binds SLC4A10 (Gene)
Sodium bicarbonate (Compound) causes Metabolic alkalosis (Side Effect)
Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Dexamethasone
Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Sodium bicarbonate may lead to a major life threatening interaction when taken with Dolutegravir