DDInter1852 DDInter1123
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcut
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.
Treprostinil {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Treprostinil {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) resembles {v} (Compound) Mannitol
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amlodipine
Amlodipine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amlodipine
Amlodipine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Treprostinil {u} may lead to a major life threatening interaction when taken with {v} Rivaroxaban
Rivaroxaban {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Treprostinil {u} may lead to a major life threatening interaction when taken with {v} Rivaroxaban
Rivaroxaban {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Treprostinil {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nadolol
Nadolol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Treprostinil {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nadolol
Nadolol {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Mannitol
Treprostinil (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Treprostinil (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) resembles Mannitol (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Treprostinil may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Treprostinil may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Treprostinil (Compound) resembles Nadolol (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Treprostinil (Compound) resembles Nadolol (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Mannitol (Compound)