DDInter1397 DDInter1197
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Metoclopramide
Paroxetine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Paroxetine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Benzatropine
Benzatropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Paroxetine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Paroxetine {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Sexual dysfunction {u} (Side Effect) is caused by {v} (Compound) Clonidine
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Paroxetine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} (Compound) resembles {v} (Compound) Metoclopramide
Paroxetine {u} (Compound) causes {v} (Side Effect) Torticollis
Torticollis {u} (Side Effect) is caused by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Paroxetine {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Dopamine
Dopamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Paroxetine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Cinchocaine
Cinchocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Paroxetine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cisapride (Compound) and Cisapride (Compound) resembles Metoclopramide (Compound)
Paroxetine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Benzatropine (Compound) and Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Paroxetine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)
Paroxetine (Compound) causes Sexual dysfunction (Side Effect) and Sexual dysfunction (Side Effect) is caused by Clonidine (Compound) and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Paroxetine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Sunitinib (Compound) and Sunitinib (Compound) resembles Metoclopramide (Compound)
Paroxetine (Compound) causes Torticollis (Side Effect) and Torticollis (Side Effect) is caused by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Paroxetine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dopamine (Compound) and Dopamine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Paroxetine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Cinchocaine (Compound) and Cinchocaine (Compound) resembles Metoclopramide (Compound)