DDInter458 DDInter1334
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase, subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene. Olsalazine is used in the treatment of ulcerative colitis.[L45023,L45151]
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is palliated by {v} (Compound) Magnesium salicylate
Magnesium salicylate {u} (Compound) resembles {v} (Compound) Olsalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Magnesium salicylate
Magnesium salicylate {u} (Compound) resembles {v} (Compound) Olsalazine
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is associated with {v} (Gene) IFNG
IFNG {u} (Gene) is bound by {v} (Compound) Olsalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is treated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Olsalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Gallium nitrate
Gallium nitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Oesophagitis
Oesophagitis {u} (Side Effect) is caused by {v} (Compound) Iodixanol
Iodixanol {u} may lead to a major life threatening interaction when taken with {v} Olsalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Iohexol
Iohexol {u} may lead to a major life threatening interaction when taken with {v} Olsalazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Mesalazine
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is palliated by Magnesium salicylate (Compound) and Magnesium salicylate (Compound) resembles Olsalazine (Compound)
Cyclosporine (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Magnesium salicylate (Compound) and Magnesium salicylate (Compound) resembles Olsalazine (Compound)
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is associated with IFNG (Gene) and IFNG (Gene) is bound by Olsalazine (Compound)
Cyclosporine (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is treated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Cyclosporine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Salsalate (Compound) and Salsalate (Compound) resembles Olsalazine (Compound)
Cyclosporine (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Gallium nitrate (Compound) and Gallium nitrate may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Cyclosporine (Compound) causes Oesophagitis (Side Effect) and Oesophagitis (Side Effect) is caused by Iodixanol (Compound) and Iodixanol may lead to a major life threatening interaction when taken with Olsalazine
Cyclosporine (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Iohexol (Compound) and Iohexol may lead to a major life threatening interaction when taken with Olsalazine
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Mesalazine (Compound) and Mesalazine (Compound) resembles Olsalazine (Compound)