DDInter1867 DDInter1448
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including the treatment of hypertensive episodes, prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and treatment of pharmacologically-induced mydriasis.[L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and topically.
Triflupromazine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentolamine
Triflupromazine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ADRA2C
ADRA2C {u} (Gene) is bound by {v} (Compound) Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin degludec
Insulin degludec {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Alimemazine
Alimemazine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phentolamine
Triflupromazine {u} (Compound) resembles {v} (Compound) Perphenazine
Perphenazine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Phentolamine
Triflupromazine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Phentolamine (Compound)
Triflupromazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine
Triflupromazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine
Triflupromazine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ADRA2C (Gene) and ADRA2C (Gene) is bound by Phentolamine (Compound)
Triflupromazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a minor interaction that can limit clinical effects when taken with Phentolamine
Triflupromazine (Compound) resembles Clomipramine (Compound) and Clomipramine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Phentolamine (Compound)
Triflupromazine (Compound) resembles Alimemazine (Compound) and Alimemazine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Phentolamine (Compound)
Triflupromazine (Compound) resembles Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine
Triflupromazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Phentolamine
Triflupromazine (Compound) resembles Perphenazine (Compound) and Perphenazine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Phentolamine (Compound)