DDInter1662 DDInter212
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Sertraline {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) upregulates {v} (Gene) FDFT1
FDFT1 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is regulated by {v} (Gene) RYBP
RYBP {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is regulated by {v} (Gene) CNOT4
CNOT4 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) upregulates {v} (Gene) FDFT1
FDFT1 {u} (Gene) regulates {v} (Gene) CNOT4
CNOT4 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Sertraline {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} (Compound) resembles {v} (Compound) Bisacodyl
Sertraline {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) GPR55
GPR55 {u} (Gene) is bound by {v} (Compound) Bisacodyl
Sertraline (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Bisacodyl (Compound)
Sertraline (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Bisacodyl (Compound)
Sertraline (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Bisacodyl (Compound)
Sertraline (Compound) upregulates FDFT1 (Gene) and FDFT1 (Gene) is downregulated by Bisacodyl (Compound)
Sertraline (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Sertraline (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is regulated by RYBP (Gene) and RYBP (Gene) is upregulated by Bisacodyl (Compound)
Sertraline (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is regulated by CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Bisacodyl (Compound)
Sertraline (Compound) upregulates FDFT1 (Gene) and FDFT1 (Gene) regulates CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Bisacodyl (Compound)
Sertraline (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Chlorpheniramine (Compound) and Chlorpheniramine (Compound) resembles Bisacodyl (Compound)
Sertraline (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by GPR55 (Gene) and GPR55 (Gene) is bound by Bisacodyl (Compound)