DDInter458 DDInter632
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system and peripherally in the gastrointestinal system. Agonism of peripheral mu-opioid receptors results in reduced colonic motility, while antagonism of central delta-opioid receptors results in improved analgesia, making eluxadoline usable for the symptoms of both pain and diarrhea characteristic of IBS-D. Marketed under the tradename Viberzi (FDA), eluxadoline is an antimotility agent that decreases bowel contractions, inhibits colonic transit, and reduces ﬂuid/ion secretion resulting in improved symptoms of abdominal pain and reductions in the Bristol Stool Scale.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Probenecid
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Atorvastatin
Atorvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Rifampicin
Rifampicin {u} may lead to a major life threatening interaction when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Probenecid
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Probenecid
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Nalbuphine
Nalbuphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) downregulates {v} (Gene) HMG20B
HMG20B {u} (Gene) is downregulated by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eluxadoline
Cyclosporine {u} (Compound) causes {v} (Side Effect) Haematuria
Haematuria {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Eluxadoline
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Probenecid (Compound) and Probenecid may cause a minor interaction that can limit clinical effects when taken with Eluxadoline
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Atorvastatin (Compound) and Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Cyclosporine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Rifampicin (Compound) and Rifampicin may lead to a major life threatening interaction when taken with Eluxadoline
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Probenecid (Compound) and Probenecid may cause a minor interaction that can limit clinical effects when taken with Eluxadoline
Cyclosporine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Probenecid (Compound) and Probenecid may cause a minor interaction that can limit clinical effects when taken with Eluxadoline
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Nalbuphine (Compound) and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Cyclosporine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Cyclosporine (Compound) downregulates HMG20B (Gene) and HMG20B (Gene) is downregulated by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Cyclosporine (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Eluxadoline