DDInter777 DDInter899
Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Fosamprenavir {u} (Compound) resembles {v} (Compound) Darunavir
Fosamprenavir {u} (Compound) binds {v} (Gene) CYP3A4
Fosamprenavir {u} (Compound) causes {v} (Side Effect) Neutropenia
Fosamprenavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Fosamprenavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Fosamprenavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gadobenic acid
Fosamprenavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rivaroxaban
Fosamprenavir {u} may lead to a major life threatening interaction when taken with {v} Salmeterol
Fosamprenavir {u} may lead to a major life threatening interaction when taken with {v} Fedratinib
Fosamprenavir (Compound) resembles Darunavir (Compound)
Fosamprenavir (Compound) binds CYP3A4 (Gene)
Fosamprenavir (Compound) causes Neutropenia (Side Effect)
Fosamprenavir may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Fosamprenavir may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Gadobenic acid
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Fosamprenavir may lead to a major life threatening interaction when taken with Salmeterol
Fosamprenavir may lead to a major life threatening interaction when taken with Fedratinib