DDInter1532 DDInter1376
A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Promazine {u} (Compound) resembles {v} (Compound) Propiomazine
Promazine {u} (Compound) resembles {v} (Compound) Ethopropazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Promazine {u} (Compound) binds {v} (Gene) ADRA2A
Promazine {u} (Compound) upregulates {v} (Gene) EBP
Promazine {u} (Compound) downregulates {v} (Gene) EZH2
Promazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Promazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium carbonate
Promazine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Promazine (Compound) resembles Propiomazine (Compound)
Promazine (Compound) resembles Ethopropazine (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Promazine (Compound) binds ADRA2A (Gene)
Promazine (Compound) upregulates EBP (Gene)
Promazine (Compound) downregulates EZH2 (Gene)
Promazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Promazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Promazine may lead to a major life threatening interaction when taken with Bupropion