DDInter1233 DDInter705
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is downregulated by {v} (Compound) Exemestane
Mitotane {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Exemestane
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is downregulated by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Exemestane
Mitotane {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Conjugated estrogens
Conjugated estrogens {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exemestane
Mitotane {u} (Compound) causes {v} (Side Effect) Hypercholesterolaemia
Hypercholesterolaemia {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} (Compound) resembles {v} (Compound) Exemestane
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Exemestane
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) regulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is upregulated by {v} (Compound) Exemestane
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) upregulates {v} (Gene) IGHMBP2
IGHMBP2 {u} (Gene) is upregulated by {v} (Compound) Exemestane
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Exemestane
Mitotane {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Dabrafenib
Dabrafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exemestane
Mitotane (Compound) upregulates ADGRE5 (Gene) and ADGRE5 (Gene) is downregulated by Exemestane (Compound)
Mitotane (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Exemestane (Compound)
Mitotane (Compound) upregulates ADGRE5 (Gene) and ADGRE5 (Gene) is downregulated by Testosterone (Compound) and Testosterone (Compound) resembles Exemestane (Compound)
Mitotane (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Conjugated estrogens (Compound) and Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Exemestane
Mitotane (Compound) causes Hypercholesterolaemia (Side Effect) and Hypercholesterolaemia (Side Effect) is caused by Prednisone (Compound) and Prednisone (Compound) resembles Exemestane (Compound)
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Exemestane (Compound)
Mitotane (Compound) upregulates ADGRE5 (Gene) and ADGRE5 (Gene) regulates TXNRD1 (Gene) and TXNRD1 (Gene) is upregulated by Exemestane (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) upregulates IGHMBP2 (Gene) and IGHMBP2 (Gene) is upregulated by Exemestane (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Exemestane (Compound)
Mitotane (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Dabrafenib (Compound) and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Exemestane