DDInter1938 DDInter299
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Vincristine {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Vincristine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Vincristine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Carfilzomib
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Vincristine {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) interacts with {v} (Gene) PSMB10
PSMB10 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Vincristine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Carfilzomib
Vincristine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Carfilzomib
Vincristine {u} (Compound) causes {v} (Side Effect) Cardiac arrest
Cardiac arrest {u} (Side Effect) is caused by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Vincristine (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is bound by Carfilzomib (Compound)
Vincristine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound)
Vincristine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Vincristine (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) interacts with PSMB10 (Gene) and PSMB10 (Gene) is bound by Carfilzomib (Compound)
Vincristine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ritonavir (Compound) and Ritonavir (Compound) resembles Carfilzomib (Compound)
Vincristine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ritonavir (Compound) and Ritonavir (Compound) resembles Carfilzomib (Compound)
Vincristine (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is bound by Carfilzomib (Compound)