DDInter1538 DDInter1055
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Propofol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Propofol {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Propofol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Propofol {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Propofol {u} (Compound) causes {v} (Side Effect) Euphoric mood
Euphoric mood {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Propofol {u} (Compound) resembles {v} (Compound) Fospropofol
Fospropofol {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Propofol {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Propofol {u} (Compound) binds {v} (Gene) UGT1A9
UGT1A9 {u} (Gene) regulates {v} (Gene) PTPRO
PTPRO {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Propofol {u} (Compound) binds {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is upregulated by {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Propofol {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Propofol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Propofol (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Propofol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Levofloxacin (Compound)
Propofol (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Propofol (Compound) causes Euphoric mood (Side Effect) and Euphoric mood (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Propofol (Compound) resembles Fospropofol (Compound) and Fospropofol (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Levofloxacin (Compound)
Propofol (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Propofol (Compound) binds UGT1A9 (Gene) and UGT1A9 (Gene) regulates PTPRO (Gene) and PTPRO (Gene) is downregulated by Levofloxacin (Compound)
Propofol (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is upregulated by chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)
Propofol (Compound) binds ALB (Gene) and ALB (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Levofloxacin (Compound)