DDInter1678 DDInter255
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Sirolimus {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) downregulates {v} (Gene) TP53BP2
TP53BP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) upregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Busulfan
Sirolimus {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) regulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) upregulates {v} (Gene) SOCS2
SOCS2 {u} (Gene) is regulated by {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is regulated by {v} (Gene) TBXA2R
TBXA2R {u} (Gene) is upregulated by {v} (Compound) Busulfan
Sirolimus {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Sirolimus (Compound) upregulates C5 (Gene) and C5 (Gene) is upregulated by Busulfan (Compound)
Sirolimus (Compound) downregulates TP53BP2 (Gene) and TP53BP2 (Gene) is upregulated by Busulfan (Compound)
Sirolimus (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Busulfan (Compound)
Sirolimus (Compound) upregulates TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Busulfan (Compound)
Sirolimus (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Busulfan (Compound)
Sirolimus (Compound) upregulates C5 (Gene) and C5 (Gene) regulates PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)
Sirolimus (Compound) upregulates SOCS2 (Gene) and SOCS2 (Gene) is regulated by MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Busulfan (Compound)
Sirolimus (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is regulated by TBXA2R (Gene) and TBXA2R (Gene) is upregulated by Busulfan (Compound)
Sirolimus (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)