DDInter416 DDInter1291
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer durations of action. The most popular of the third generation dihydropyridines is [amlodipine]. Nifedipine was granted FDA approval on 31 December 1981.
Clotrimazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is regulated by {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Isradipine
Isradipine {u} (Compound) resembles {v} (Compound) Nifedipine
Clotrimazole {u} (Compound) causes {v} (Side Effect) Abdominal distension
Abdominal distension {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nifedipine
Clotrimazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Nifedipine (Compound)
Clotrimazole (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Nifedipine (Compound)
Clotrimazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amlodipine (Compound) and Amlodipine (Compound) resembles Nifedipine (Compound)
Clotrimazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nicardipine (Compound) and Nicardipine (Compound) resembles Nifedipine (Compound)
Clotrimazole (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Nifedipine (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is regulated by MYC (Gene) and MYC (Gene) is upregulated by Nifedipine (Compound)
Clotrimazole (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Amlodipine (Compound) and Amlodipine (Compound) resembles Nifedipine (Compound)
Clotrimazole (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Isradipine (Compound) and Isradipine (Compound) resembles Nifedipine (Compound)
Clotrimazole (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine