DDInter1158 DDInter542
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Mesalazine {u} (Compound) downregulates {v} (Gene) SLC35F2
SLC35F2 {u} (Gene) is downregulated by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) regulates {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is associated with {v} (Gene) GPR35
GPR35 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is regulated by {v} (Gene) GPR35
GPR35 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) binds {v} (Gene) IKBKB
IKBKB {u} (Gene) regulates {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Mesalazine {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is downregulated by {v} (Compound) Dicoumarol
Mesalazine (Compound) downregulates SLC35F2 (Gene) and SLC35F2 (Gene) is downregulated by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Mesalazine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Mesalazine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) regulates NQO1 (Gene) and NQO1 (Gene) is bound by Dicoumarol (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) resembles Dicoumarol (Compound)
Mesalazine (Compound) resembles Diflunisal (Compound) and Diflunisal may lead to a major life threatening interaction when taken with Warfarin and Warfarin (Compound) resembles Dicoumarol (Compound)
Mesalazine (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dicoumarol (Compound)
Mesalazine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is associated with GPR35 (Gene) and GPR35 (Gene) is bound by Dicoumarol (Compound)
Mesalazine (Compound) downregulates SPR (Gene) and SPR (Gene) is regulated by GPR35 (Gene) and GPR35 (Gene) is bound by Dicoumarol (Compound)
Mesalazine (Compound) binds IKBKB (Gene) and IKBKB (Gene) regulates NQO1 (Gene) and NQO1 (Gene) is bound by Dicoumarol (Compound)
Mesalazine (Compound) downregulates SPR (Gene) and SPR (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is downregulated by Dicoumarol (Compound)