DDInter1607 DDInter1531
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Proguanil
Ritonavir {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Proguanil
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Ritonavir {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Artemether
Artemether {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Ritonavir {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Lamotrigine
Lamotrigine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Proguanil
Ritonavir {u} (Compound) causes {v} (Side Effect) Hepatobiliary disease
Hepatobiliary disease {u} (Side Effect) is caused by {v} (Compound) Quinapril
Quinapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Ritonavir {u} (Compound) resembles {v} (Compound) Lopinavir
Lopinavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Proguanil
Ritonavir {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Proguanil
Ritonavir {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Auranofin
Auranofin {u} may lead to a major life threatening interaction when taken with {v} Proguanil
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Proguanil (Compound)
Ritonavir (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Proguanil (Compound)
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Ritonavir (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Artemether (Compound) and Artemether may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Ritonavir (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Lamotrigine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Proguanil
Ritonavir (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Quinapril (Compound) and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Ritonavir (Compound) resembles Lopinavir (Compound) and Lopinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Proguanil (Compound)
Ritonavir (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Proguanil
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Proguanil (Compound)
Ritonavir (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Auranofin (Compound) and Auranofin may lead to a major life threatening interaction when taken with Proguanil