DDInter298 DDInter1054
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier[Label,A177781]. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson's[Label]. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975[A177781,L6133].
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Levodopa
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Carbidopa
Carbidopa {u} (Compound) resembles {v} (Compound) Levodopa
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Levodopa
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Levodopa
Carboplatin {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Aluminum hydroxide
Aluminum hydroxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levodopa
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levodopa
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Ephedrine
Ephedrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Carboplatin {u} (Compound) treats {v} (Disease) brain cancer
brain cancer {u} (Disease) is associated with {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Levodopa
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Levodopa (Compound)
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Carbidopa (Compound) and Carbidopa (Compound) resembles Levodopa (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Melphalan (Compound) and Melphalan (Compound) resembles Levodopa (Compound)
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Melphalan (Compound) and Melphalan (Compound) resembles Levodopa (Compound)
Carboplatin (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Aluminum hydroxide (Compound) and Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Levodopa
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a minor interaction that can limit clinical effects when taken with Levodopa
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ephedrine (Compound) and Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Carboplatin (Compound) treats brain cancer (Disease) and brain cancer (Disease) is associated with PCNA (Gene) and PCNA (Gene) is downregulated by Levodopa (Compound)