DDInter355 DDInter535
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Flurbiprofen
Flurbiprofen {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Temazepam
Temazepam {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) regulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) downregulates {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Chlordiazepoxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Magnesium hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Chlordiazepoxide (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Diazoxide (Compound)
Chlordiazepoxide (Compound) resembles Flurbiprofen (Compound) and Flurbiprofen (Compound) upregulates AGL (Gene) and AGL (Gene) is upregulated by Diazoxide (Compound)
Chlordiazepoxide (Compound) resembles Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Chlordiazepoxide (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Diazoxide (Compound)
Chlordiazepoxide (Compound) resembles Temazepam (Compound) and Temazepam (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Diazoxide (Compound)
Chlordiazepoxide (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) regulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Diazoxide (Compound)
Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Diazoxide (Compound)
Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) downregulates CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Chlordiazepoxide may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide and Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Diazoxide (Compound)