DDInter527 DDInter1631
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Dextromethorphan {u} (Compound) resembles {v} (Compound) Levallorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydromorphone
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP3A4
Dextromethorphan {u} (Compound) upregulates {v} (Gene) PYCR1
Dextromethorphan {u} (Compound) palliates {v} (Disease) amyotrophic lateral sclerosis
Dextromethorphan {u} (Compound) is included by {v} (Pharmacologic Class) Uncompetitive NMDA Receptor Antagonists
Dextromethorphan {u} (Compound) downregulates {v} (Gene) GJA1
Dextromethorphan {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Dextromethorphan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Memantine
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rolapitant
Dextromethorphan (Compound) resembles Levallorphan (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone
Dextromethorphan (Compound) binds CYP3A4 (Gene)
Dextromethorphan (Compound) upregulates PYCR1 (Gene)
Dextromethorphan (Compound) palliates amyotrophic lateral sclerosis (Disease)
Dextromethorphan (Compound) is included by Uncompetitive NMDA Receptor Antagonists (Pharmacologic Class)
Dextromethorphan (Compound) downregulates GJA1 (Gene)
Dextromethorphan (Compound) causes Abdominal discomfort (Side Effect)
Dextromethorphan may cause a minor interaction that can limit clinical effects when taken with Memantine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant