DDInter255 DDInter1033
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Busulfan {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Busulfan {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Busulfan {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) ACOT9
ACOT9 {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Busulfan {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) PTK2B
PTK2B {u} (Gene) is bound by {v} (Compound) Leflunomide
Busulfan {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) interacts with {v} (Gene) CREB1
CREB1 {u} (Gene) is upregulated by {v} (Compound) Leflunomide
Busulfan {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is associated with {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Leflunomide
Busulfan {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Busulfan {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Montelukast
Montelukast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Busulfan {u} (Compound) causes {v} (Side Effect) Interstitial lung disease
Interstitial lung disease {u} (Side Effect) is caused by {v} (Compound) Lapatinib
Lapatinib {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Busulfan {u} (Compound) causes {v} (Side Effect) Endocrine disorder
Endocrine disorder {u} (Side Effect) is caused by {v} (Compound) Voriconazole
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Busulfan (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Leflunomide (Compound)
Busulfan (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Busulfan (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates ACOT9 (Gene) and ACOT9 (Gene) is downregulated by Leflunomide (Compound)
Busulfan (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates PTK2B (Gene) and PTK2B (Gene) is bound by Leflunomide (Compound)
Busulfan (Compound) downregulates DLD (Gene) and DLD (Gene) interacts with CREB1 (Gene) and CREB1 (Gene) is upregulated by Leflunomide (Compound)
Busulfan (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is associated with systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Leflunomide (Compound)
Busulfan (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Telbivudine (Compound) and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Busulfan (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Montelukast (Compound) and Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Busulfan (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Lapatinib (Compound) and Lapatinib may lead to a major life threatening interaction when taken with Leflunomide
Busulfan (Compound) causes Endocrine disorder (Side Effect) and Endocrine disorder (Side Effect) is caused by Voriconazole (Compound) and Voriconazole may lead to a major life threatening interaction when taken with Leflunomide