DDInter93 DDInter1867
Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythemia treatments (e.g. [busulfan], [hydroxyurea]) and may be better tolerated.
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Anagrelide {u} may lead to a major life threatening interaction when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Triflupromazine
Anagrelide {u} may lead to a major life threatening interaction when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) EBP
EBP {u} (Gene) is bound by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Desipramine
Desipramine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Anagrelide may lead to a major life threatening interaction when taken with Perphenazine and Perphenazine (Compound) resembles Triflupromazine (Compound)
Anagrelide (Compound) downregulates EBP (Gene) and EBP (Gene) is upregulated by Triflupromazine (Compound)
Anagrelide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Triflupromazine (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Perphenazine and Perphenazine (Compound) resembles Pipotiazine (Compound) and Pipotiazine (Compound) resembles Triflupromazine (Compound)
Anagrelide (Compound) downregulates EBP (Gene) and EBP (Gene) is upregulated by Perphenazine (Compound) and Perphenazine (Compound) resembles Triflupromazine (Compound)
Anagrelide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Perphenazine (Compound) and Perphenazine (Compound) resembles Triflupromazine (Compound)
Anagrelide (Compound) downregulates EBP (Gene) and EBP (Gene) is bound by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Triflupromazine (Compound)
Anagrelide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Triflupromazine (Compound)
Anagrelide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Desipramine (Compound) and Desipramine (Compound) resembles Triflupromazine (Compound)
Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Triflupromazine (Compound)