DDInter336 DDInter1515
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955.
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Prednisone
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Prednisone
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Prednisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Arthralgia
Arthralgia {u} (Side Effect) is caused by {v} (Compound) Prednisone
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Mometasone
Mometasone {u} (Compound) resembles {v} (Compound) Prednisone
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Prednisone
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Prednisone
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Prednisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Arthralgia
Arthralgia {u} (Side Effect) is caused by {v} (Compound) Ciclesonide
Ciclesonide {u} (Compound) resembles {v} (Compound) Prednisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Gastrointestinal haemorrhage
Gastrointestinal haemorrhage {u} (Side Effect) is caused by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prednisone
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Prednisone (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prednisone (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Prednisone (Compound)
Celecoxib (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Prednisone (Compound)
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Mometasone (Compound) and Mometasone (Compound) resembles Prednisone (Compound)
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is palliated by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Prednisone (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Prednisone (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Prednisone (Compound)
Celecoxib (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Ciclesonide (Compound) and Ciclesonide (Compound) resembles Prednisone (Compound)
Celecoxib (Compound) causes Gastrointestinal haemorrhage (Side Effect) and Gastrointestinal haemorrhage (Side Effect) is caused by Ticlopidine (Compound) and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Prednisone