DDInter527 DDInter1747
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Dextromethorphan {u} (Compound) resembles {v} (Compound) Levallorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydromorphone
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP3A4
Dextromethorphan {u} (Compound) upregulates {v} (Gene) PYCR1
Dextromethorphan {u} (Compound) palliates {v} (Disease) amyotrophic lateral sclerosis
Dextromethorphan {u} (Compound) is included by {v} (Pharmacologic Class) Uncompetitive NMDA Receptor Antagonists
Dextromethorphan {u} (Compound) downregulates {v} (Gene) GJA1
Dextromethorphan {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Dextromethorphan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Memantine
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rolapitant
Dextromethorphan (Compound) resembles Levallorphan (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone
Dextromethorphan (Compound) binds CYP3A4 (Gene)
Dextromethorphan (Compound) upregulates PYCR1 (Gene)
Dextromethorphan (Compound) palliates amyotrophic lateral sclerosis (Disease)
Dextromethorphan (Compound) is included by Uncompetitive NMDA Receptor Antagonists (Pharmacologic Class)
Dextromethorphan (Compound) downregulates GJA1 (Gene)
Dextromethorphan (Compound) causes Abdominal discomfort (Side Effect)
Dextromethorphan may cause a minor interaction that can limit clinical effects when taken with Memantine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant