DDInter576 DDInter1391
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypnotic and sedative agent due to its CNS depressant properties. Paraldehyde is used as an ingredient in some cough medicines as an expectorant, but its efficacy for this indication has not been confirmed and its use as an expectorant may possibly be due to a placebo effect.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Paraldehyde
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paraldehyde
Disulfiram {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) is downregulated by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paraldehyde
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paraldehyde
Disulfiram {u} (Compound) causes {v} (Side Effect) Erectile dysfunction
Erectile dysfunction {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Paraldehyde
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Morphine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Paraldehyde
Disulfiram {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Bupropion
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paraldehyde
Disulfiram {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Dextromethorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paraldehyde
Disulfiram {u} (Compound) downregulates {v} (Gene) SMARCD2
SMARCD2 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paraldehyde
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a minor interaction that can limit clinical effects when taken with Paraldehyde
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Disulfiram (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Disulfiram (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Morphine (Compound) and Morphine may lead to a major life threatening interaction when taken with Paraldehyde
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Morphine (Compound) and Morphine may lead to a major life threatening interaction when taken with Paraldehyde
Disulfiram (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Bupropion (Compound) and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Disulfiram (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Dextromethorphan (Compound) and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde
Disulfiram (Compound) downregulates SMARCD2 (Gene) and SMARCD2 (Gene) is upregulated by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Paraldehyde