DDInter548 DDInter1008
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR1
ESR1 {u} (Gene) interacts with {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) COMT
COMT {u} (Gene) regulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR1
ESR1 {u} (Gene) interacts with {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESRRG
ESRRG {u} (Gene) regulates {v} (Gene) SLC35F2
SLC35F2 {u} (Gene) is downregulated by {v} (Compound) Ketoconazole
Diethylstilbestrol {u} (Compound) upregulates {v} (Gene) CCP110
CCP110 {u} (Gene) regulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Diethylstilbestrol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketoconazole (Compound)
Diethylstilbestrol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ketoconazole (Compound)
Diethylstilbestrol (Compound) binds ESR1 (Gene) and ESR1 (Gene) interacts with AR (Gene) and AR (Gene) is bound by Ketoconazole (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole and Posaconazole (Compound) resembles Ketoconazole (Compound)
Diethylstilbestrol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Diethylstilbestrol (Compound) binds COMT (Gene) and COMT (Gene) regulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Ketoconazole (Compound)
Diethylstilbestrol (Compound) binds ESR1 (Gene) and ESR1 (Gene) interacts with ALDOC (Gene) and ALDOC (Gene) is upregulated by Ketoconazole (Compound)
Diethylstilbestrol (Compound) binds ESRRG (Gene) and ESRRG (Gene) regulates SLC35F2 (Gene) and SLC35F2 (Gene) is downregulated by Ketoconazole (Compound)
Diethylstilbestrol (Compound) upregulates CCP110 (Gene) and CCP110 (Gene) regulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Ketoconazole (Compound)