DDInter569 DDInter1747
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Diphenhydramine {u} (Compound) resembles {v} (Compound) Toremifene
Diphenhydramine {u} (Compound) resembles {v} (Compound) Tropicamide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Diphenhydramine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Diphenhydramine {u} (Compound) treats {v} (Disease) atopic dermatitis
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
Diphenhydramine {u} (Compound) palliates {v} (Disease) schizophrenia
Diphenhydramine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Dizziness
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Diphenhydramine (Compound) resembles Toremifene (Compound)
Diphenhydramine (Compound) resembles Tropicamide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Diphenhydramine may lead to a major life threatening interaction when taken with Tamoxifen
Diphenhydramine (Compound) treats atopic dermatitis (Disease)
Diphenhydramine (Compound) binds CYP2B6 (Gene)
Diphenhydramine (Compound) palliates schizophrenia (Disease)
Diphenhydramine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Diphenhydramine (Compound) causes Dizziness (Side Effect)