DDInter458 DDInter1570
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is upregulated by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) P-Glycoprotein Inhibitors
P-Glycoprotein Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TPI1
TPI1 {u} (Gene) is downregulated by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) regulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is regulated by {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TPI1
TPI1 {u} (Gene) regulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is upregulated by {v} (Compound) Ranolazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Carvedilol
Carvedilol {u} (Compound) resembles {v} (Compound) Ranolazine
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ranolazine (Compound)
Cyclosporine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Ranolazine (Compound)
Cyclosporine (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class) and P-Glycoprotein Inhibitors (Pharmacologic Class) includes Ranolazine (Compound)
Cyclosporine (Compound) downregulates TPI1 (Gene) and TPI1 (Gene) is downregulated by Ranolazine (Compound)
Cyclosporine (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Ranolazine (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bupivacaine (Compound) and Bupivacaine (Compound) resembles Ranolazine (Compound)
Cyclosporine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) regulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Ranolazine (Compound)
Cyclosporine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is regulated by ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Ranolazine (Compound)
Cyclosporine (Compound) downregulates TPI1 (Gene) and TPI1 (Gene) regulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Ranolazine (Compound)
Cyclosporine (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Carvedilol (Compound) and Carvedilol (Compound) resembles Ranolazine (Compound)