DDInter82 DDInter576
Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Amoxapine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is downregulated by {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) regulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) binds {v} (Gene) HTR7
HTR7 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is regulated by {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) covaries with {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) regulates {v} (Gene) C2CD5
C2CD5 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Amoxapine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is regulated by {v} (Gene) BIRC5
BIRC5 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Amoxapine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Disulfiram (Compound)
Amoxapine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Disulfiram (Compound)
Amoxapine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Amoxapine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is downregulated by alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Amoxapine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) regulates ABHD4 (Gene) and ABHD4 (Gene) is upregulated by Disulfiram (Compound)
Amoxapine (Compound) binds HTR7 (Gene) and HTR7 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Amoxapine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is regulated by KDM5A (Gene) and KDM5A (Gene) is upregulated by Disulfiram (Compound)
Amoxapine (Compound) binds DRD2 (Gene) and DRD2 (Gene) covaries with DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Disulfiram (Compound)
Amoxapine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) regulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Disulfiram (Compound)
Amoxapine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is regulated by BIRC5 (Gene) and BIRC5 (Gene) is downregulated by Disulfiram (Compound)