DDInter1763 DDInter1315
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active.
Temsirolimus {u} (Compound) resembles {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Temsirolimus {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Temsirolimus {u} (Compound) resembles {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Temsirolimus {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Temsirolimus {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Temsirolimus {u} (Compound) resembles {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dulaglutide
Dulaglutide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Temsirolimus {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Temsirolimus {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Temsirolimus {u} (Compound) resembles {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Larotrectinib
Larotrectinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Temsirolimus {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Temsirolimus (Compound) resembles Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Temsirolimus (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Temsirolimus (Compound) resembles Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Temsirolimus (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Temsirolimus (Compound) upregulates MYC (Gene) and MYC (Gene) is upregulated by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Temsirolimus (Compound) resembles Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Temsirolimus (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Temsirolimus (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Rosuvastatin (Compound) and Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Temsirolimus (Compound) resembles Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Temsirolimus (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel