DDInter1960 DDInter1155
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Mepyramine {u} (Compound) resembles {v} (Compound) Chloropyramine
Mepyramine {u} (Compound) resembles {v} (Compound) Pheniramine
Mepyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Mepyramine {u} (Compound) binds {v} (Gene) CYP2D6
Mepyramine {u} (Compound) upregulates {v} (Gene) PAK1
Mepyramine {u} (Compound) causes {v} (Side Effect) Skin sensitisation
Mepyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Mepyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Umeclidinium
Mepyramine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Mepyramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Mepyramine (Compound) resembles Chloropyramine (Compound)
Mepyramine (Compound) resembles Pheniramine (Compound)
Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Mepyramine (Compound) binds CYP2D6 (Gene)
Mepyramine (Compound) upregulates PAK1 (Gene)
Mepyramine (Compound) causes Skin sensitisation (Side Effect)
Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Mepyramine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Mepyramine (Compound) resembles Methotrimeprazine (Compound) and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine