DDInter466 DDInter255
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Dactinomycin {u} (Compound) upregulates {v} (Gene) PRKX
PRKX {u} (Gene) is upregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) downregulates {v} (Gene) TEX10
TEX10 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) downregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) upregulates {v} (Gene) OXCT1
OXCT1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) causes {v} (Side Effect) Venoocclusive disease
Venoocclusive disease {u} (Side Effect) is caused by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) upregulates {v} (Gene) PRKX
PRKX {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) regulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) upregulates {v} (Gene) MAMLD1
MAMLD1 {u} (Gene) is regulated by {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) upregulates {v} (Gene) SOCS2
SOCS2 {u} (Gene) is regulated by {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Dactinomycin {u} (Compound) downregulates {v} (Gene) TEX10
TEX10 {u} (Gene) is regulated by {v} (Gene) ABL1
ABL1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Dactinomycin (Compound) upregulates PRKX (Gene) and PRKX (Gene) is upregulated by Busulfan (Compound)
Dactinomycin (Compound) downregulates TEX10 (Gene) and TEX10 (Gene) is upregulated by Busulfan (Compound)
Dactinomycin (Compound) downregulates TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Busulfan (Compound)
Dactinomycin (Compound) upregulates OXCT1 (Gene) and OXCT1 (Gene) is downregulated by Busulfan (Compound)
Dactinomycin (Compound) causes Venoocclusive disease (Side Effect) and Venoocclusive disease (Side Effect) is caused by Busulfan (Compound)
Dactinomycin (Compound) upregulates PRKX (Gene) and PRKX (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)
Dactinomycin (Compound) upregulates C5 (Gene) and C5 (Gene) regulates PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)
Dactinomycin (Compound) upregulates MAMLD1 (Gene) and MAMLD1 (Gene) is regulated by PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Dactinomycin (Compound) upregulates SOCS2 (Gene) and SOCS2 (Gene) is regulated by MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Busulfan (Compound)
Dactinomycin (Compound) downregulates TEX10 (Gene) and TEX10 (Gene) is regulated by ABL1 (Gene) and ABL1 (Gene) is upregulated by Busulfan (Compound)