DDInter413 DDInter119
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease, It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin. Clopidogrel was granted FDA approval on 17 November 1997.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Clopidogrel {u} may lead to a major life threatening interaction when taken with {v} Ticlopidine
Clopidogrel {u} (Compound) treats {v} (Disease) coronary artery disease
Clopidogrel {u} (Compound) binds {v} (Gene) P2RY12
Clopidogrel {u} (Compound) upregulates {v} (Gene) TBXA2R
Clopidogrel {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Platelet Aggregation
Clopidogrel {u} (Compound) downregulates {v} (Gene) DECR1
Clopidogrel {u} (Compound) causes {v} (Side Effect) Deafness
Clopidogrel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluvastatin
Clopidogrel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Torasemide
Clopidogrel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Modafinil
Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Clopidogrel (Compound) treats coronary artery disease (Disease)
Clopidogrel (Compound) binds P2RY12 (Gene)
Clopidogrel (Compound) upregulates TBXA2R (Gene)
Clopidogrel (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class)
Clopidogrel (Compound) downregulates DECR1 (Gene)
Clopidogrel (Compound) causes Deafness (Side Effect)
Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Fluvastatin
Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Torasemide
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Modafinil