DDInter268 DDInter1460
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.[A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects.[A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenytoin
Calcitriol {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Phenytoin
Calcitriol {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Calcitriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Ergocalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Phenytoin
Calcitriol {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Phenytoin
Calcitriol {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Phenytoin
Calcitriol {u} (Compound) causes {v} (Side Effect) Haemoglobin
Haemoglobin {u} (Side Effect) is caused by {v} (Compound) Oxaprozin
Oxaprozin {u} (Compound) resembles {v} (Compound) Phenytoin
Calcitriol {u} (Compound) causes {v} (Side Effect) Taste metallic
Taste metallic {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenytoin
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenytoin (Compound)
Calcitriol (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Phenytoin (Compound)
Calcitriol (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Phenytoin (Compound)
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin
Calcitriol (Compound) resembles Ergocalciferol (Compound) and Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Modafinil (Compound) and Modafinil (Compound) resembles Phenytoin (Compound)
Calcitriol (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Phenytoin (Compound)
Calcitriol (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Modafinil (Compound) and Modafinil (Compound) resembles Phenytoin (Compound)
Calcitriol (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Oxaprozin (Compound) and Oxaprozin (Compound) resembles Phenytoin (Compound)
Calcitriol (Compound) causes Taste metallic (Side Effect) and Taste metallic (Side Effect) is caused by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Phenytoin