DDInter702 DDInter576
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Etoposide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Etoposide {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) upregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) downregulates {v} (Gene) C2CD5
C2CD5 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Etoposide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Etoposide {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Etoposide (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Etoposide (Compound) downregulates MYC (Gene) and MYC (Gene) is upregulated by Disulfiram (Compound)
Etoposide (Compound) upregulates DDB2 (Gene) and DDB2 (Gene) is downregulated by Disulfiram (Compound)
Etoposide (Compound) downregulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Disulfiram (Compound)
Etoposide (Compound) binds TOP2A (Gene) and Etoposide (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is downregulated by Disulfiram (Compound)
Etoposide (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Disulfiram (Compound)
Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Etoposide (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Etoposide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)