DDInter576 DDInter593
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter indication was presented by Pernix Therapeutics.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Doxepin
Disulfiram {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) is downregulated by {v} (Compound) Doxepin
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Disulfiram {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Doxepin
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Doxepin
Disulfiram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Thiothixene {u} (Compound) resembles {v} (Compound) Doxepin
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Citalopram
Citalopram {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Disulfiram {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) regulates {v} (Gene) SDC1
SDC1 {u} (Gene) is downregulated by {v} (Compound) Doxepin
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound)
Disulfiram (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Doxepin (Compound)
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Doxepin (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Disulfiram (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Doxepin (Compound)
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Doxepin (Compound)
Disulfiram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Thiothixene (Compound) and Thiothixene (Compound) resembles Doxepin (Compound)
Disulfiram (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Citalopram (Compound) and Citalopram may lead to a major life threatening interaction when taken with Doxepin
Disulfiram (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) regulates SDC1 (Gene) and SDC1 (Gene) is downregulated by Doxepin (Compound)