DDInter366 DDInter576
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Chlorzoxazone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Chlorzoxazone {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Chlorzoxazone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Chlorzoxazone {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Chlorzoxazone {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Chlorzoxazone {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Chlorzoxazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Chlorzoxazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Chlorzoxazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Chlorzoxazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Cetirizine {u} (Compound) downregulates {v} (Gene) FIS1
FIS1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Chlorzoxazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Chlorzoxazone (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Disulfiram (Compound)
Chlorzoxazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Chlorzoxazone (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Chlorzoxazone (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Disulfiram (Compound)
Chlorzoxazone (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Disulfiram (Compound)
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine (Compound) downregulates FIS1 (Gene) and FIS1 (Gene) is downregulated by Disulfiram (Compound)