DDInter150 DDInter431
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
Azathioprine {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Colchicine
Azathioprine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Azathioprine {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Colchicine
Azathioprine {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) resembles {v} (Disease) primary biliary cirrhosis
primary biliary cirrhosis {u} (Disease) is treated by {v} (Compound) Colchicine
Azathioprine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) regulates {v} (Gene) KIF20A
KIF20A {u} (Gene) is upregulated by {v} (Compound) Colchicine
Azathioprine {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Azathioprine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Phenylpropanolamine
Phenylpropanolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Colchicine
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Trimethobenzamide
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Colchicine
Azathioprine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Leflunomide
Leflunomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Azathioprine {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) downregulates {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Colchicine
Azathioprine (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Colchicine (Compound)
Azathioprine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) is downregulated by Colchicine (Compound)
Azathioprine (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Colchicine (Compound)
Azathioprine (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) resembles primary biliary cirrhosis (Disease) and primary biliary cirrhosis (Disease) is treated by Colchicine (Compound)
Azathioprine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) regulates KIF20A (Gene) and KIF20A (Gene) is upregulated by Colchicine (Compound)
Azathioprine (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Azathioprine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Phenylpropanolamine (Compound) and Phenylpropanolamine may cause a minor interaction that can limit clinical effects when taken with Colchicine
Azathioprine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Trimethobenzamide (Compound) and Trimethobenzamide (Compound) resembles Colchicine (Compound)
Azathioprine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Leflunomide (Compound) and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Azathioprine (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) downregulates ABCB1 (Gene) and ABCB1 (Gene) is bound by Colchicine (Compound)