DDInter1675 DDInter1956
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) resembles {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) downregulates {v} (Gene) YME1L1
YME1L1 {u} (Gene) is upregulated by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) upregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Simvastatin {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) resembles Zalcitabine (Compound)
Simvastatin (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Zalcitabine (Compound)
Simvastatin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Zalcitabine (Compound)
Simvastatin (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Zalcitabine (Compound)
Simvastatin (Compound) downregulates YME1L1 (Gene) and YME1L1 (Gene) is upregulated by Zalcitabine (Compound)
Simvastatin (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Zalcitabine (Compound)
Simvastatin (Compound) upregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Zalcitabine (Compound)
Simvastatin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Zalcitabine (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Simvastatin (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Emtricitabine (Compound) and Emtricitabine (Compound) resembles Zalcitabine (Compound)