DDInter336 DDInter809
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) regulates {v} (Gene) SLC35B1
SLC35B1 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) regulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Generalised oedema
Generalised oedema {u} (Side Effect) is caused by {v} (Compound) Cisplatin
Cisplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Vemurafenib
Vemurafenib {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Gatifloxacin (Compound)
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Gatifloxacin (Compound)
Celecoxib (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Gatifloxacin (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) regulates SLC35B1 (Gene) and SLC35B1 (Gene) is downregulated by Gatifloxacin (Compound)
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) regulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Gatifloxacin (Compound)
Celecoxib (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Celecoxib (Compound) causes Generalised oedema (Side Effect) and Generalised oedema (Side Effect) is caused by Cisplatin (Compound) and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Celecoxib (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gatifloxacin (Compound)
Celecoxib (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Capecitabine (Compound) and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) resembles Vemurafenib (Compound) and Vemurafenib may lead to a major life threatening interaction when taken with Gatifloxacin