DDInter1905 DDInter1397
Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ticagrelor
Ticagrelor {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ticagrelor
Ticagrelor {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) binds {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) downregulates {v} (Gene) TIMELESS
TIMELESS {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perindopril
Perindopril {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aminocaproic acid
Aminocaproic acid {u} (Compound) upregulates {v} (Gene) TATDN2
TATDN2 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Urokinase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venlafaxine
Venlafaxine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Urokinase {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Dasatinib {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Urokinase {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Dasatinib {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) binds NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) downregulates TIMELESS (Gene) and TIMELESS (Gene) is downregulated by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Perindopril and Perindopril (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Aminocaproic acid and Aminocaproic acid (Compound) upregulates TATDN2 (Gene) and TATDN2 (Gene) is downregulated by Paroxetine (Compound)
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)
Urokinase may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Urokinase may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Paroxetine (Compound)