DDInter458 DDInter810
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is upregulated by {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Iloperidone
Iloperidone {u} (Compound) resembles {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Erlotinib
Erlotinib {u} (Compound) resembles {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is upregulated by {v} (Compound) Afatinib
Afatinib {u} (Compound) resembles {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Bosutinib
Bosutinib {u} (Compound) resembles {v} (Compound) Gefitinib
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Afatinib
Afatinib {u} (Compound) resembles {v} (Compound) Gefitinib
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Gefitinib (Compound)
Cyclosporine (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Gefitinib (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Gefitinib (Compound)
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Gefitinib (Compound)
Cyclosporine (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Gefitinib (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Iloperidone (Compound) and Iloperidone (Compound) resembles Gefitinib (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Erlotinib (Compound) and Erlotinib (Compound) resembles Gefitinib (Compound)
Cyclosporine (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Afatinib (Compound) and Afatinib (Compound) resembles Gefitinib (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Bosutinib (Compound) and Bosutinib (Compound) resembles Gefitinib (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Afatinib (Compound) and Afatinib (Compound) resembles Gefitinib (Compound)