DDInter1647 DDInter1180
Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analogue, scopolamine can antagonize muscarinic acetylcholine receptors (mAChRs) in the central nervous system and throughout the body, inducing several therapeutic and adverse effects related to alteration of parasympathetic nervous system and cholinergic signalling.[A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981.[A228423,
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Scopolamine {u} (Compound) resembles {v} (Compound) Homatropine Methylbromide
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Scopolamine {u} (Compound) resembles {v} (Compound) Methylscopolamine bromide
Scopolamine {u} (Compound) binds {v} (Gene) CHRM4
Scopolamine {u} (Compound) upregulates {v} (Gene) MCOLN1
Scopolamine {u} (Compound) causes {v} (Side Effect) Photophobia
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metolazone
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nadolol
Scopolamine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Scopolamine (Compound) resembles Homatropine Methylbromide (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Scopolamine (Compound) resembles Methylscopolamine bromide (Compound)
Scopolamine (Compound) binds CHRM4 (Gene)
Scopolamine (Compound) upregulates MCOLN1 (Gene)
Scopolamine (Compound) causes Photophobia (Side Effect)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Metolazone
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Phenelzine
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol
Scopolamine may lead to a major life threatening interaction when taken with Potassium chloride