DDInter1158 DDInter763
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) is upregulated by {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) resembles {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) resembles {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) regulates {v} (Gene) SFTPA2
SFTPA2 {u} (Gene) is upregulated by {v} (Compound) Flurbiprofen
Mesalazine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Flurbiprofen (Compound)
Mesalazine (Compound) upregulates AGL (Gene) and AGL (Gene) is upregulated by Flurbiprofen (Compound)
Mesalazine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Flurbiprofen (Compound)
Mesalazine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Mesalazine (Compound) resembles Diflunisal (Compound) and Diflunisal (Compound) resembles Flurbiprofen (Compound) and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) resembles Flurbiprofen (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Tiaprofenic acid (Compound) and PTGS2 (Gene) is upregulated by Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) resembles Flurbiprofen (Compound)
Mesalazine (Compound) upregulates AGL (Gene) and AGL (Gene) regulates SFTPA2 (Gene) and SFTPA2 (Gene) is upregulated by Flurbiprofen (Compound)
Mesalazine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Flurbiprofen (Compound)