DDInter747 DDInter782
Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position of the steroid structure - this fluorination is thought to be crucial to fludrocortisone's significant mineralocorticoid potency.
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form of netupitant [FDA label]. Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting as major side effects. Considered one of the most distressing side effects of chemotherapy, nausea and vomiting has an immense impact on the quality of life of patients receiving certain antineoplastic therapies .
Fludrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Testosterone
Fludrocortisone {u} (Compound) binds {v} (Gene) NR3C1
Fludrocortisone {u} (Compound) palliates {v} (Disease) Parkinson's disease
Fludrocortisone {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticlopidine
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisacodyl
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Certolizumab pegol
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Moxifloxacin
Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Testosterone
Fludrocortisone (Compound) binds NR3C1 (Gene)
Fludrocortisone (Compound) palliates Parkinson's disease (Disease)
Fludrocortisone (Compound) causes Hyperglycaemia (Side Effect)
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Ticlopidine
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Fludrocortisone may lead to a major life threatening interaction when taken with Certolizumab pegol
Fludrocortisone may lead to a major life threatening interaction when taken with Moxifloxacin