DDInter1620 DDInter1768
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Ropivacaine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) upregulates {v} (Gene) GRAMD3
GRAMD3 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) downregulates {v} (Gene) EEF1A2
EEF1A2 {u} (Gene) is downregulated by {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Hepatic function abnormal {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) upregulates {v} (Gene) GRAMD3
GRAMD3 {u} (Gene) is regulated by {v} (Gene) P4HA2
P4HA2 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) upregulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) upregulates {v} (Gene) ST3GAL5
ST3GAL5 {u} (Gene) is upregulated by {v} (Compound) Naphazoline
Naphazoline {u} (Compound) resembles {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) downregulates {v} (Gene) EEF1A2
EEF1A2 {u} (Gene) is regulated by {v} (Gene) DMTF1
DMTF1 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Ropivacaine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) regulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Ropivacaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Ropivacaine (Compound) upregulates GRAMD3 (Gene) and GRAMD3 (Gene) is upregulated by Terbinafine (Compound)
Ropivacaine (Compound) downregulates EEF1A2 (Gene) and EEF1A2 (Gene) is downregulated by Terbinafine (Compound)
Ropivacaine (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Terbinafine (Compound)
Ropivacaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Terbinafine (Compound)
Ropivacaine (Compound) upregulates GRAMD3 (Gene) and GRAMD3 (Gene) is regulated by P4HA2 (Gene) and P4HA2 (Gene) is upregulated by Terbinafine (Compound)
Ropivacaine (Compound) upregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Terbinafine (Compound)
Ropivacaine (Compound) upregulates ST3GAL5 (Gene) and ST3GAL5 (Gene) is upregulated by Naphazoline (Compound) and Naphazoline (Compound) resembles Terbinafine (Compound)
Ropivacaine (Compound) downregulates EEF1A2 (Gene) and EEF1A2 (Gene) is regulated by DMTF1 (Gene) and DMTF1 (Gene) is upregulated by Terbinafine (Compound)
Ropivacaine (Compound) downregulates DCK (Gene) and DCK (Gene) regulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Terbinafine (Compound)