DDInter576 DDInter1572
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Disulfiram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Rasagiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Rasagiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Procarbazine
Procarbazine {u} may lead to a major life threatening interaction when taken with {v} Rasagiline
Disulfiram {u} (Compound) binds {v} (Gene) DBH
DBH {u} (Gene) is associated with {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Rasagiline
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Dextromethorphan {u} may lead to a major life threatening interaction when taken with {v} Rasagiline
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Disulfiram {u} (Compound) binds {v} (Gene) ALDH2
ALDH2 {u} (Gene) is bound by {v} (Compound) Amyl Nitrite
Amyl Nitrite {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Disulfiram {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rasagiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy peripheral
Neuropathy peripheral {u} (Side Effect) is caused by {v} (Compound) Vemurafenib
Vemurafenib {u} may lead to a major life threatening interaction when taken with {v} Rasagiline
Disulfiram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Disulfiram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is associated with MAOB (Gene) and MAOB (Gene) is bound by Rasagiline (Compound)
Disulfiram (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Procarbazine (Compound) and Procarbazine may lead to a major life threatening interaction when taken with Rasagiline
Disulfiram (Compound) binds DBH (Gene) and DBH (Gene) is associated with Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Rasagiline (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound) and Dextromethorphan may lead to a major life threatening interaction when taken with Rasagiline
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Disulfiram (Compound) binds ALDH2 (Gene) and ALDH2 (Gene) is bound by Amyl Nitrite (Compound) and Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Disulfiram (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Disulfiram (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Vemurafenib (Compound) and Vemurafenib may lead to a major life threatening interaction when taken with Rasagiline