DDInter557 DDInter1952
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Xylometazoline is an alkylbenzene.
Dihydroergotamine {u} (Compound) binds {v} (Gene) HTR1D
HTR1D {u} (Gene) is bound by {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Xylometazoline
Dihydroergotamine {u} (Compound) binds {v} (Gene) HTR1D
HTR1D {u} (Gene) is bound by {v} (Compound) Oxymetazoline
Oxymetazoline {u} (Compound) resembles {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} (Compound) binds {v} (Gene) ADRA1D
ADRA1D {u} (Gene) is bound by {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) binds {v} (Gene) HTR1D
HTR1D {u} (Gene) interacts with {v} (Gene) HTR1B
HTR1B {u} (Gene) is bound by {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) binds {v} (Gene) HTR1B
HTR1B {u} (Gene) interacts with {v} (Gene) HTR1D
HTR1D {u} (Gene) is bound by {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) binds {v} (Gene) HTR2B
HTR2B {u} (Gene) is bound by {v} (Compound) Amoxapine
Amoxapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Xylometazoline
Dihydroergotamine {u} (Compound) palliates {v} (Disease) migraine
migraine {u} (Disease) is associated with {v} (Gene) HTR1D
HTR1D {u} (Gene) is bound by {v} (Compound) Xylometazoline
Dihydroergotamine {u} (Compound) binds {v} (Gene) HTR1D
HTR1D {u} (Gene) is bound by {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Xylometazoline
Dihydroergotamine (Compound) binds HTR1D (Gene) and HTR1D (Gene) is bound by Xylometazoline (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Xylometazoline
Dihydroergotamine (Compound) binds HTR1D (Gene) and HTR1D (Gene) is bound by Oxymetazoline (Compound) and Oxymetazoline (Compound) resembles Xylometazoline (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine (Compound) binds ADRA1D (Gene) and ADRA1D (Gene) is bound by Xylometazoline (Compound)
Dihydroergotamine (Compound) binds HTR1D (Gene) and HTR1D (Gene) interacts with HTR1B (Gene) and HTR1B (Gene) is bound by Xylometazoline (Compound)
Dihydroergotamine (Compound) binds HTR1B (Gene) and HTR1B (Gene) interacts with HTR1D (Gene) and HTR1D (Gene) is bound by Xylometazoline (Compound)
Dihydroergotamine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Xylometazoline (Compound)
Dihydroergotamine (Compound) binds HTR2B (Gene) and HTR2B (Gene) is bound by Amoxapine (Compound) and Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Dihydroergotamine (Compound) palliates migraine (Disease) and migraine (Disease) is associated with HTR1D (Gene) and HTR1D (Gene) is bound by Xylometazoline (Compound)
Dihydroergotamine (Compound) binds HTR1D (Gene) and HTR1D (Gene) is bound by Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Xylometazoline