DDInter458 DDInter583
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia.[L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia. Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Donepezil
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is downregulated by {v} (Compound) Donepezil
Cyclosporine {u} (Compound) upregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is downregulated by {v} (Compound) Donepezil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abdominal pain upper
Abdominal pain upper {u} (Side Effect) is caused by {v} (Compound) Donepezil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Doxazosin
Doxazosin {u} (Compound) resembles {v} (Compound) Donepezil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Zafirlukast
Zafirlukast {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) regulates {v} (Gene) CANT1
CANT1 {u} (Gene) is downregulated by {v} (Compound) Donepezil
Cyclosporine {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) is upregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) interacts with {v} (Gene) TGFBR2
TGFBR2 {u} (Gene) is upregulated by {v} (Compound) Donepezil
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Donepezil (Compound)
Cyclosporine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Donepezil (Compound)
Cyclosporine (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is downregulated by Donepezil (Compound)
Cyclosporine (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Donepezil (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Doxazosin (Compound) and Doxazosin (Compound) resembles Donepezil (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zafirlukast (Compound) and Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Donepezil
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) regulates CANT1 (Gene) and CANT1 (Gene) is downregulated by Donepezil (Compound)
Cyclosporine (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Dasatinib (Compound) and Dasatinib may cause a minor interaction that can limit clinical effects when taken with Donepezil
Cyclosporine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) interacts with TGFBR2 (Gene) and TGFBR2 (Gene) is upregulated by Donepezil (Compound)