DDInter1675 DDInter576
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Simvastatin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) upregulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) upregulates {v} (Gene) ARHGAP1
ARHGAP1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) regulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Simvastatin {u} (Compound) upregulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is regulated by {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Simvastatin (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Simvastatin (Compound) upregulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Disulfiram (Compound)
Simvastatin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Simvastatin (Compound) upregulates ARHGAP1 (Gene) and ARHGAP1 (Gene) is downregulated by Disulfiram (Compound)
Simvastatin (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Disulfiram (Compound)
Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Simvastatin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)
Simvastatin (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) regulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Disulfiram (Compound)
Simvastatin (Compound) upregulates LAMA3 (Gene) and LAMA3 (Gene) is regulated by FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)