DDInter815 DDInter434
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams. This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications,
Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} (Compound) causes {v} (Side Effect) Salivary hypersecretion
Salivary hypersecretion {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistin
Colistin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistin
Colistin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Doxacurium
Doxacurium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Gentamicin may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistimethate (Compound)
Gentamicin (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Colistimethate (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Bacitracin and Bacitracin (Compound) resembles Colistin (Compound) and Colistin (Compound) resembles Colistimethate (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Gentamicin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Polymyxin B (Compound) and Polymyxin B (Compound) resembles Colistimethate (Compound)
Gentamicin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Gentamicin (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistin (Compound) and Colistin (Compound) resembles Colistimethate (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Doxacurium and Doxacurium may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)