DDInter1432 DDInter535
An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Perphenazine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Perphenazine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Perphenazine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is regulated by {v} (Gene) GLUL
GLUL {u} (Gene) is bound by {v} (Compound) Diazoxide
Perphenazine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Perphenazine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is regulated by {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Perphenazine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) regulates {v} (Gene) EPCAM
EPCAM {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Perphenazine {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is regulated by {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Perphenazine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) regulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Perphenazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Perphenazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Perphenazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Diazoxide (Compound)
Perphenazine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Perphenazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is regulated by GLUL (Gene) and GLUL (Gene) is bound by Diazoxide (Compound)
Perphenazine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Perphenazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is regulated by KRT19 (Gene) and KRT19 (Gene) is upregulated by Diazoxide (Compound)
Perphenazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) regulates EPCAM (Gene) and EPCAM (Gene) is upregulated by Diazoxide (Compound)
Perphenazine (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is regulated by GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Diazoxide (Compound)
Perphenazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) regulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Diazoxide (Compound)
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)