DDInter1675 DDInter1652
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Simvastatin {u} (Compound) treats {v} (Disease) atherosclerosis
Simvastatin {u} (Compound) binds {v} (Gene) ABCC2
Simvastatin {u} (Compound) upregulates {v} (Gene) ANKRD10
Simvastatin {u} (Compound) downregulates {v} (Gene) PNP
Simvastatin {u} (Compound) causes {v} (Side Effect) Cataract
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dapagliflozin
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Liothyronine
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duvelisib
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Interferon alfacon-1
Simvastatin {u} may lead to a major life threatening interaction when taken with {v} Colchicine
Simvastatin (Compound) treats atherosclerosis (Disease)
Simvastatin (Compound) binds ABCC2 (Gene)
Simvastatin (Compound) upregulates ANKRD10 (Gene)
Simvastatin (Compound) downregulates PNP (Gene)
Simvastatin (Compound) causes Cataract (Side Effect)
Simvastatin may cause a minor interaction that can limit clinical effects when taken with Dapagliflozin
Simvastatin may cause a minor interaction that can limit clinical effects when taken with Liothyronine
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1
Simvastatin may lead to a major life threatening interaction when taken with Colchicine