DDInter702 DDInter255
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Etoposide {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Etoposide {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Busulfan
Etoposide {u} (Compound) downregulates {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Etoposide {u} (Compound) upregulates {v} (Gene) GPER1
GPER1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Etoposide {u} (Compound) upregulates {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Etoposide {u} (Compound) downregulates {v} (Gene) USP22
USP22 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Etoposide {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Etoposide {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Etoposide {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Etoposide {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Etoposide (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is bound by Busulfan (Compound)
Etoposide (Compound) downregulates PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Etoposide (Compound) upregulates GPER1 (Gene) and GPER1 (Gene) is upregulated by Busulfan (Compound)
Etoposide (Compound) upregulates DNAJB2 (Gene) and DNAJB2 (Gene) is downregulated by Busulfan (Compound)
Etoposide (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Busulfan (Compound)
Etoposide (Compound) binds TOP2A (Gene) and Etoposide (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Etoposide (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Busulfan (Compound)
Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Etoposide (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)