DDInter1853 DDInter813
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
Tretinoin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Retinal haemorrhage
Retinal haemorrhage {u} (Side Effect) is caused by {v} (Compound) Procarbazine
Procarbazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Creatine phosphokinase increased
Creatine phosphokinase increased {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Blood creatine phosphokinase increased
Blood creatine phosphokinase increased {u} (Side Effect) is caused by {v} (Compound) Melphalan
Melphalan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Blood creatine phosphokinase increased
Blood creatine phosphokinase increased {u} (Side Effect) is caused by {v} (Compound) Saxagliptin
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Retinal haemorrhage
Retinal haemorrhage {u} (Side Effect) is caused by {v} (Compound) Glipizide
Glipizide {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Blood creatine phosphokinase increased
Blood creatine phosphokinase increased {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Tretinoin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Gemifloxacin (Compound)
Tretinoin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Tretinoin (Compound) causes Retinal haemorrhage (Side Effect) and Retinal haemorrhage (Side Effect) is caused by Procarbazine (Compound) and Procarbazine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Tretinoin (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gemifloxacin (Compound)
Tretinoin (Compound) causes Creatine phosphokinase increased (Side Effect) and Creatine phosphokinase increased (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Tretinoin (Compound) causes Blood creatine phosphokinase increased (Side Effect) and Blood creatine phosphokinase increased (Side Effect) is caused by Melphalan (Compound) and Melphalan may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Tretinoin (Compound) causes Blood creatine phosphokinase increased (Side Effect) and Blood creatine phosphokinase increased (Side Effect) is caused by Saxagliptin (Compound) and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Tretinoin (Compound) causes Retinal haemorrhage (Side Effect) and Retinal haemorrhage (Side Effect) is caused by Glipizide (Compound) and Glipizide may lead to a major life threatening interaction when taken with Gemifloxacin
Tretinoin (Compound) causes Blood creatine phosphokinase increased (Side Effect) and Blood creatine phosphokinase increased (Side Effect) is caused by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Gemifloxacin
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gemifloxacin (Compound)