DDInter856 DDInter1948
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake of serotonin. More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. SMSs were developed because there are many different subtypes of serotonin receptors, however, not all of these receptors appear to be involved in the antidepressant effects of SRIs. Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional role in the efficacy of SRIs in treating depression.
Vortioxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Elagolix
Vortioxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anistreplase
Vortioxetine {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Vortioxetine {u} may lead to a major life threatening interaction when taken with {v} Dacomitinib
Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Vortioxetine may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase
Vortioxetine may lead to a major life threatening interaction when taken with Doxepin
Vortioxetine may lead to a major life threatening interaction when taken with Dacomitinib