DDInter1791 DDInter48
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals . Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout . It was initially approved by the FDA in 1966 and is now formulated by several manufacturers .
Theophylline {u} (Compound) binds {v} (Gene) SLC22A7
SLC22A7 {u} (Gene) is bound by {v} (Compound) Allopurinol
Theophylline {u} (Compound) causes {v} (Side Effect) Status epilepticus
Status epilepticus {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Hydrocortisone {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Allopurinol
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Hydrocortisone {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Estradiol
Estradiol {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Allopurinol
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxycycline
Doxycycline {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Allopurinol
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acyclovir
Acyclovir {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Allopurinol
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acyclovir
Acyclovir {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Theophylline {u} (Compound) resembles {v} (Compound) Dyphylline
Dyphylline {u} (Compound) causes {v} (Side Effect) Muscle twitching
Muscle twitching {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Caffeine
Caffeine {u} (Compound) causes {v} (Side Effect) Sepsis
Sepsis {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Theophylline (Compound) binds SLC22A7 (Gene) and SLC22A7 (Gene) is bound by Allopurinol (Compound)
Theophylline (Compound) causes Status epilepticus (Side Effect) and Status epilepticus (Side Effect) is caused by Allopurinol (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) treats gout (Disease) and gout (Disease) is treated by Allopurinol (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Allopurinol (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Allopurinol (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Allopurinol (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Acyclovir and Acyclovir (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Allopurinol (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Acyclovir and Acyclovir (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Allopurinol (Compound)
Theophylline (Compound) resembles Dyphylline (Compound) and Dyphylline (Compound) causes Muscle twitching (Side Effect) and Muscle twitching (Side Effect) is caused by Allopurinol (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Allopurinol (Compound)