DDInter583 DDInter704
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia.[L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia. Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Donepezil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Donepezil {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Donepezil {u} (Compound) downregulates {v} (Gene) CANT1
CANT1 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Donepezil {u} (Compound) causes {v} (Side Effect) Erythropenia
Erythropenia {u} (Side Effect) is caused by {v} (Compound) Everolimus
Donepezil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Donepezil {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) regulates {v} (Gene) CDK5R1
CDK5R1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Donepezil {u} (Compound) upregulates {v} (Gene) RSU1
RSU1 {u} (Gene) is regulated by {v} (Gene) SNRK
SNRK {u} (Gene) is upregulated by {v} (Compound) Everolimus
Donepezil {u} (Compound) downregulates {v} (Gene) CANT1
CANT1 {u} (Gene) is regulated by {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Donepezil {u} (Compound) downregulates {v} (Gene) TP53BP1
TP53BP1 {u} (Gene) interacts with {v} (Gene) HIST1H3H
HIST1H3H {u} (Gene) is upregulated by {v} (Compound) Everolimus
Donepezil {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Donepezil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound)
Donepezil (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Everolimus (Compound)
Donepezil (Compound) downregulates CANT1 (Gene) and CANT1 (Gene) is downregulated by Everolimus (Compound)
Donepezil (Compound) causes Erythropenia (Side Effect) and Erythropenia (Side Effect) is caused by Everolimus (Compound)
Donepezil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Donepezil (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) regulates CDK5R1 (Gene) and CDK5R1 (Gene) is upregulated by Everolimus (Compound)
Donepezil (Compound) upregulates RSU1 (Gene) and RSU1 (Gene) is regulated by SNRK (Gene) and SNRK (Gene) is upregulated by Everolimus (Compound)
Donepezil (Compound) downregulates CANT1 (Gene) and CANT1 (Gene) is regulated by INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Everolimus (Compound)
Donepezil (Compound) downregulates TP53BP1 (Gene) and TP53BP1 (Gene) interacts with HIST1H3H (Gene) and HIST1H3H (Gene) is upregulated by Everolimus (Compound)
Donepezil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)