DDInter1620 DDInter351
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.[L43942,L44022]
Ropivacaine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) downregulates {v} (Gene) S100A6
S100A6 {u} (Gene) is downregulated by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Ropivacaine {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) CD55
CD55 {u} (Gene) is bound by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) upregulates {v} (Gene) TF
TF {u} (Gene) is regulated by {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) downregulates {v} (Gene) S100A6
S100A6 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is regulated by {v} (Gene) KIT
KIT {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ropivacaine {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Ropivacaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Chloramphenicol (Compound)
Ropivacaine (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Chloramphenicol (Compound)
Ropivacaine (Compound) downregulates S100A6 (Gene) and S100A6 (Gene) is downregulated by Chloramphenicol (Compound)
Ropivacaine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Chloramphenicol (Compound)
Ropivacaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Ropivacaine (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by CD55 (Gene) and CD55 (Gene) is bound by Chloramphenicol (Compound)
Ropivacaine (Compound) upregulates TF (Gene) and TF (Gene) is regulated by CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Chloramphenicol (Compound)
Ropivacaine (Compound) downregulates S100A6 (Gene) and S100A6 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Chloramphenicol (Compound)
Ropivacaine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is regulated by KIT (Gene) and KIT (Gene) is upregulated by Chloramphenicol (Compound)
Ropivacaine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol