DDInter1853 DDInter1259
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Tretinoin {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) downregulates {v} (Gene) ST7
ST7 {u} (Gene) is upregulated by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) downregulates {v} (Gene) PRR7
PRR7 {u} (Gene) is downregulated by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Tretinoin {u} (Compound) downregulates {v} (Gene) ST7
ST7 {u} (Gene) regulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Nalidixic acid
Tretinoin (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Nalidixic acid (Compound)
Tretinoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Nalidixic acid (Compound)
Tretinoin (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Enoxacin (Compound) and Enoxacin (Compound) resembles Nalidixic acid (Compound)
Tretinoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Tretinoin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Tretinoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Nalidixic acid (Compound)
Tretinoin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Nalidixic acid (Compound)
Tretinoin (Compound) downregulates ST7 (Gene) and ST7 (Gene) is upregulated by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Tretinoin (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Tretinoin (Compound) downregulates ST7 (Gene) and ST7 (Gene) regulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Nalidixic acid (Compound)