DDInter685 DDInter690
Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a safer alternative to other drugs used for insomnia. One major benefit of eszopiclone is that it is approved by the FDA for the long-term treatment of insomnia. This sets it apart from many other hypnotic sedatives, which are generally approved only for the relief of short-term (6-8 weeks) insomnia. Eszopiclone was initially approved by the FDA in 2004.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Eszopiclone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluconazole
Fluconazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} may lead to a major life threatening interaction when taken with {v} Clarithromycin
Clarithromycin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} (Compound) resembles {v} (Compound) Zopiclone
Zopiclone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Morphine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is associated with {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} (Compound) binds {v} (Gene) GABRA2
GABRA2 {u} (Gene) interacts with {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone {u} (Compound) downregulates {v} (Gene) TUBA1A
TUBA1A {u} (Gene) is regulated by {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Ethanol
Eszopiclone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Eszopiclone may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Eszopiclone (Compound) resembles Zopiclone (Compound) and Zopiclone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Eszopiclone may lead to a major life threatening interaction when taken with Morphine and Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Eszopiclone (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is associated with CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ethanol (Compound)
Eszopiclone (Compound) binds GABRA2 (Gene) and GABRA2 (Gene) interacts with GABRA1 (Gene) and GABRA1 (Gene) is bound by Ethanol (Compound)
Eszopiclone (Compound) downregulates TUBA1A (Gene) and TUBA1A (Gene) is regulated by GABRA1 (Gene) and GABRA1 (Gene) is bound by Ethanol (Compound)