DDInter825 DDInter548
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive β cell failure and long-term microvascular and macrovascular complications that lead to co-morbidities and mortalities. Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes to lower blood glucose levels. The main effect of SUs is thought to be effective when residual pancreatic β-cells are present, as they work by stimulating the release of insulin from the pancreatic beta cells and they are also thought to exert extra-pancreatic effects, such as increasing the insulin-mediated peripheral glucose uptake. Glimepiride works by stimulating the secretion of insulin granules from
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dobutamine
Dobutamine {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dobutamine
Dobutamine {u} (Compound) binds {v} (Gene) COMT
COMT {u} (Gene) is bound by {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Corticotropin
Corticotropin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisolone
Prednisolone {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diethylstilbestrol
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Ritodrine (Compound) and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Tamoxifen (Compound) and Tamoxifen (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) binds COMT (Gene) and COMT (Gene) is bound by Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a minor interaction that can limit clinical effects when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diethylstilbestrol (Compound)