DDInter350 DDInter1335
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) downregulates {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) upregulates {v} (Gene) LRPAP1
LRPAP1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is regulated by {v} (Gene) COG4
COG4 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) downregulates {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is regulated by {v} (Gene) ETS1
ETS1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) regulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNA2
CCNA2 {u} (Gene) regulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) downregulates {v} (Gene) ZNF23
ZNF23 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) upregulates LRPAP1 (Gene) and LRPAP1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is regulated by COG4 (Gene) and COG4 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is regulated by ETS1 (Gene) and ETS1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) regulates CHIC2 (Gene) and CHIC2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) downregulates CCNA2 (Gene) and CCNA2 (Gene) regulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) downregulates ZNF23 (Gene) and ZNF23 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)