DDInter1844 DDInter1853
Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Tranexamic acid {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) binds {v} (Gene) PLG
PLG {u} (Gene) interacts with {v} (Gene) HSPB1
HSPB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) binds {v} (Gene) SLC15A2
SLC15A2 {u} (Gene) is regulated by {v} (Gene) HOXA5
HOXA5 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) binds {v} (Gene) PLG
PLG {u} (Gene) interacts with {v} (Gene) IGFBP3
IGFBP3 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) upregulates {v} (Gene) YME1L1
YME1L1 {u} (Gene) regulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) downregulates {v} (Gene) KRT18
KRT18 {u} (Gene) interacts with {v} (Gene) CASP7
CASP7 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) upregulates {v} (Gene) YME1L1
YME1L1 {u} (Gene) is regulated by {v} (Gene) RXRA
RXRA {u} (Gene) is bound by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) downregulates {v} (Gene) TCEB2
TCEB2 {u} (Gene) is regulated by {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Tranexamic acid {u} (Compound) downregulates {v} (Gene) KRT18
KRT18 {u} (Gene) is regulated by {v} (Gene) RXRA
RXRA {u} (Gene) is bound by {v} (Compound) Tretinoin
Tranexamic acid (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Tretinoin (Compound)
Tranexamic acid (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Tranexamic acid (Compound) binds PLG (Gene) and PLG (Gene) interacts with HSPB1 (Gene) and HSPB1 (Gene) is downregulated by Tretinoin (Compound)
Tranexamic acid (Compound) binds SLC15A2 (Gene) and SLC15A2 (Gene) is regulated by HOXA5 (Gene) and HOXA5 (Gene) is upregulated by Tretinoin (Compound)
Tranexamic acid (Compound) binds PLG (Gene) and PLG (Gene) interacts with IGFBP3 (Gene) and IGFBP3 (Gene) is upregulated by Tretinoin (Compound)
Tranexamic acid (Compound) upregulates YME1L1 (Gene) and YME1L1 (Gene) regulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Tretinoin (Compound)
Tranexamic acid (Compound) downregulates KRT18 (Gene) and KRT18 (Gene) interacts with CASP7 (Gene) and CASP7 (Gene) is upregulated by Tretinoin (Compound)
Tranexamic acid (Compound) upregulates YME1L1 (Gene) and YME1L1 (Gene) is regulated by RXRA (Gene) and RXRA (Gene) is bound by Tretinoin (Compound)
Tranexamic acid (Compound) downregulates TCEB2 (Gene) and TCEB2 (Gene) is regulated by STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Tranexamic acid (Compound) downregulates KRT18 (Gene) and KRT18 (Gene) is regulated by RXRA (Gene) and RXRA (Gene) is bound by Tretinoin (Compound)