DDInter1666 DDInter416
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers . The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot .
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Bifonazole
Bifonazole {u} (Compound) resembles {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) causes {v} (Side Effect) Abdominal distension
Abdominal distension {u} (Side Effect) is caused by {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Clotrimazole
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Clotrimazole (Compound)
Sildenafil (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Clotrimazole (Compound)
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Sildenafil (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Bifonazole (Compound) and Bifonazole (Compound) resembles Clotrimazole (Compound)
Sildenafil (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Sildenafil (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Loperamide (Compound) and Loperamide (Compound) resembles Clotrimazole (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by ABCC2 (Gene) and ABCC2 (Gene) is bound by Clotrimazole (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide (Compound) resembles Clotrimazole (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clotrimazole (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Clotrimazole (Compound)