DDInter1853 DDInter1335
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Tretinoin {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) downregulates {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) downregulates {v} (Gene) CCDC85B
CCDC85B {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) upregulates {v} (Gene) PSME1
PSME1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is regulated by {v} (Gene) COG4
COG4 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) downregulates {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is regulated by {v} (Gene) ETS1
ETS1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) regulates {v} (Gene) STAP2
STAP2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) upregulates {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) interacts with {v} (Gene) TICAM1
TICAM1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin {u} (Compound) upregulates {v} (Gene) IKBKE
IKBKE {u} (Gene) interacts with {v} (Gene) RPL3
RPL3 {u} (Gene) is bound by {v} (Compound) Omacetaxine mepesuccinate
Tretinoin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) downregulates CCDC85B (Gene) and CCDC85B (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) upregulates PSME1 (Gene) and PSME1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is regulated by COG4 (Gene) and COG4 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) downregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) is regulated by ETS1 (Gene) and ETS1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) regulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) upregulates TNFAIP3 (Gene) and TNFAIP3 (Gene) interacts with TICAM1 (Gene) and TICAM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tretinoin (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) interacts with RPL3 (Gene) and RPL3 (Gene) is bound by Omacetaxine mepesuccinate (Compound)