DDInter150 DDInter172
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. It is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. It is approved for the treatment of rheumatoid arthritis. Belatacept selectively blocks the process of T-cell activation. It was developed by Bristol-Myers-Squibb. Belatacept is only 2 amino acids different from abatacept (Orencia). FDA approved on June 15, 2011.
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Azathioprine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
Azathioprine {u} (Compound) binds {v} (Gene) GSTA1
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
Azathioprine {u} (Compound) is included by {v} (Pharmacologic Class) Purines
Azathioprine {u} (Compound) downregulates {v} (Gene) STUB1
Azathioprine {u} (Compound) causes {v} (Side Effect) Hodgkin's disease
Azathioprine (Compound) resembles Adenine (Compound)
Azathioprine (Compound) treats systemic lupus erythematosus (Disease)
Azathioprine (Compound) binds GSTA1 (Gene)
Azathioprine (Compound) upregulates NUCB2 (Gene)
Azathioprine (Compound) is included by Purines (Pharmacologic Class)
Azathioprine (Compound) downregulates STUB1 (Gene)
Azathioprine (Compound) causes Hodgkin's disease (Side Effect)