DDInter110 DDInter1376
Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Apraclonidine {u} (Compound) resembles {v} (Compound) Clonidine
Apraclonidine {u} (Compound) resembles {v} (Compound) Lofexidine
Apraclonidine {u} (Compound) treats {v} (Disease) glaucoma
Apraclonidine {u} (Compound) binds {v} (Gene) ADRA2B
Apraclonidine {u} (Compound) causes {v} (Side Effect) Tension
Apraclonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Apraclonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Apraclonidine {u} may lead to a major life threatening interaction when taken with {v} Procarbazine
Apraclonidine (Compound) resembles Clonidine (Compound)
Apraclonidine (Compound) resembles Lofexidine (Compound)
Apraclonidine (Compound) treats glaucoma (Disease)
Apraclonidine (Compound) binds ADRA2B (Gene)
Apraclonidine (Compound) causes Tension (Side Effect)
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Apraclonidine may lead to a major life threatening interaction when taken with Procarbazine