DDInter507 DDInter336
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH. It has been employed clinically since 1972
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Desmopressin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Desmopressin {u} (Compound) resembles {v} (Compound) Terlipressin
Terlipressin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) PDPK1
PDPK1 {u} (Gene) is bound by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) resembles {v} (Compound) Gonadorelin
Gonadorelin {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Desmopressin {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Desmopressin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Etoricoxib (Compound) and PTGS2 (Gene) is upregulated by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Desmopressin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Desmopressin (Compound) resembles Terlipressin (Compound) and Terlipressin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Celecoxib (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by PDPK1 (Gene) and PDPK1 (Gene) is bound by Celecoxib (Compound)
Desmopressin (Compound) resembles Gonadorelin (Compound) and Gonadorelin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Celecoxib (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Celecoxib (Compound)
Desmopressin (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Desmopressin (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is downregulated by Celecoxib (Compound)