DDInter1151 DDInter1376
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Mephentermine {u} (Compound) resembles {v} (Compound) Phenformin
Mephentermine {u} (Compound) resembles {v} (Compound) Amphetamine
Mephentermine {u} (Compound) binds {v} (Gene) ADRA1A
Mephentermine {u} (Compound) upregulates {v} (Gene) CSTA
Mephentermine {u} (Compound) downregulates {v} (Gene) CYCS
Mephentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dulaglutide
Mephentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glulisine
Mephentermine {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Mephentermine {u} may lead to a major life threatening interaction when taken with {v} Cocaine
Mephentermine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentermine
Mephentermine (Compound) resembles Phenformin (Compound)
Mephentermine (Compound) resembles Amphetamine (Compound)
Mephentermine (Compound) binds ADRA1A (Gene)
Mephentermine (Compound) upregulates CSTA (Gene)
Mephentermine (Compound) downregulates CYCS (Gene)
Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide
Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Mephentermine may lead to a major life threatening interaction when taken with Methylene blue
Mephentermine may lead to a major life threatening interaction when taken with Cocaine
Mephentermine (Compound) resembles Phentermine (Compound) and Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine