DDInter655 DDInter255
An anthracycline which is the 4&#39;-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Epirubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) downregulates {v} (Gene) TEX10
TEX10 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) upregulates {v} (Gene) DECR1
DECR1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Epirubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Epirubicin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is regulated by {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Epirubicin {u} (Compound) upregulates {v} (Gene) PRKX
PRKX {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Epirubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Epirubicin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Epirubicin (Compound) downregulates TEX10 (Gene) and TEX10 (Gene) is upregulated by Busulfan (Compound)
Epirubicin (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by Busulfan (Compound)
Epirubicin (Compound) upregulates DECR1 (Gene) and DECR1 (Gene) is downregulated by Busulfan (Compound)
Epirubicin (Compound) binds TOP2A (Gene) and Epirubicin (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Epirubicin (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Epirubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Epirubicin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is regulated by PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Epirubicin (Compound) upregulates PRKX (Gene) and PRKX (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)