DDInter336 DDInter856
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Celecoxib {u} (Compound) binds {v} (Gene) CA14
Celecoxib {u} (Compound) upregulates {v} (Gene) ST3GAL5
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Celecoxib {u} (Compound) downregulates {v} (Gene) TUBB2B
Celecoxib {u} (Compound) causes {v} (Side Effect) Nausea
Celecoxib (Compound) resembles Sulfaphenazole (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound)
Celecoxib (Compound) binds CA14 (Gene)
Celecoxib (Compound) upregulates ST3GAL5 (Gene)
Celecoxib (Compound) palliates osteoarthritis (Disease)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Celecoxib (Compound) downregulates TUBB2B (Gene)
Celecoxib (Compound) causes Nausea (Side Effect)