DDInter298 DDInter1055
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) RB1
RB1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is associated with {v} (Gene) and {u} (Disease) upregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) binds {v} (Gene) SOD1
SOD1 {u} (Gene) regulates {v} (Gene) PTPN1
PTPN1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Carboplatin {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) covaries with {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Levofloxacin (Compound)
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with RB1 (Gene) and RB1 (Gene) is downregulated by Levofloxacin (Compound)
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is associated with TOP2A (Gene) and breast cancer (Disease) upregulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates CPVL (Gene) and CPVL (Gene) is upregulated by Levofloxacin (Compound)
Carboplatin (Compound) binds SOD1 (Gene) and SOD1 (Gene) regulates PTPN1 (Gene) and PTPN1 (Gene) is downregulated by Levofloxacin (Compound)
Carboplatin (Compound) binds MPO (Gene) and MPO (Gene) covaries with ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Levofloxacin (Compound)