DDInter1647 DDInter981
Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analogue, scopolamine can antagonize muscarinic acetylcholine receptors (mAChRs) in the central nervous system and throughout the body, inducing several therapeutic and adverse effects related to alteration of parasympathetic nervous system and cholinergic signalling.[A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981.[A228423,
Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.
Scopolamine {u} (Compound) causes {v} (Side Effect) Amblyopia
Amblyopia {u} (Side Effect) is caused by {v} (Compound) Isocarboxazid
Scopolamine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Lacosamide
Lacosamide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Bethanidine
Bethanidine {u} (Compound) resembles {v} (Compound) Isocarboxazid
Scopolamine (Compound) causes Amblyopia (Side Effect) and Amblyopia (Side Effect) is caused by Isocarboxazid (Compound)
Scopolamine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Lacosamide (Compound) and Lacosamide (Compound) resembles Isocarboxazid (Compound)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine (Compound) resembles Phenacemide (Compound) and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Scopolamine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Metamfetamine (Compound) and Metamfetamine (Compound) resembles Isocarboxazid (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Isocarboxazid (Compound)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine (Compound) resembles Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Isocarboxazid (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine (Compound) resembles Bethanidine (Compound) and Bethanidine (Compound) resembles Isocarboxazid (Compound)