DDInter576 DDInter1840
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) downregulates {v} (Gene) CDKN1B
CDKN1B {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) upregulates {v} (Gene) BAG3
BAG3 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) upregulates {v} (Gene) ETS1
ETS1 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) upregulates {v} (Gene) DDIT3
DDIT3 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Trabectedin (Compound)
Disulfiram (Compound) downregulates CDKN1B (Gene) and CDKN1B (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) upregulates BAG3 (Gene) and BAG3 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) upregulates ETS1 (Gene) and ETS1 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) upregulates DDIT3 (Gene) and DDIT3 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Disulfiram (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with SRC (Gene) and STUB1 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)