DDInter1918 DDInter1376
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum. PDE5 inhibitors, such as vardenafil, inhibit the degradation of cGMP and allow increased blood flow into the penis, resulting in an erection.[A258303,L45563,L45568]. Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil. The FDA approved the use of v
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Udenafil
Vardenafil {u} (Compound) binds {v} (Gene) CYP3A4
Vardenafil {u} (Compound) upregulates {v} (Gene) ABCC5
Vardenafil {u} (Compound) downregulates {v} (Gene) RNH1
Vardenafil {u} (Compound) causes {v} (Side Effect) Amnesia
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palonosetron
Vardenafil {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Vardenafil {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Vardenafil (Compound) resembles Sildenafil (Compound)
Vardenafil (Compound) resembles Udenafil (Compound)
Vardenafil (Compound) binds CYP3A4 (Gene)
Vardenafil (Compound) upregulates ABCC5 (Gene)
Vardenafil (Compound) downregulates RNH1 (Gene)
Vardenafil (Compound) causes Amnesia (Side Effect)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron
Vardenafil may lead to a major life threatening interaction when taken with Hydroxychloroquine
Vardenafil may lead to a major life threatening interaction when taken with Cisapride