DDInter458 DDInter900
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID. On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Ibuprofen
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Probenecid
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Baclofen
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pancreatitis acute
Pancreatitis acute {u} (Side Effect) is caused by {v} (Compound) Ranitidine
Ranitidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Benign intracranial hypertension
Benign intracranial hypertension {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Metyrosine
Metyrosine {u} (Compound) resembles {v} (Compound) Ibuprofen
Cyclosporine {u} (Compound) upregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Carprofen
Carprofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Ibuprofen (Compound)
Cyclosporine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Probenecid (Compound) and Probenecid may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Cyclosporine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Baclofen (Compound) and Baclofen (Compound) resembles Ibuprofen (Compound)
Cyclosporine (Compound) causes Pancreatitis acute (Side Effect) and Pancreatitis acute (Side Effect) is caused by Ranitidine (Compound) and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Cyclosporine (Compound) causes Benign intracranial hypertension (Side Effect) and Benign intracranial hypertension (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Cyclosporine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Metyrosine (Compound) and Metyrosine (Compound) resembles Ibuprofen (Compound)
Cyclosporine (Compound) upregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Carprofen (Compound) and Carprofen (Compound) resembles Ibuprofen (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Indomethacin (Compound) and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen