DDInter458 DDInter1776
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, an androstanoid, a C19-steroid and a 3-oxo-Delta(4) steroid.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Testosterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Testosterone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Testosterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST7
ST7 {u} (Gene) is downregulated by {v} (Compound) Testosterone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Testosterone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Estradiol
Estradiol {u} (Compound) resembles {v} (Compound) Testosterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Testosterone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Testosterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST7
ST7 {u} (Gene) is downregulated by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Testosterone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Estradiol
Estradiol {u} (Compound) resembles {v} (Compound) Testosterone
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Testosterone (Compound)
Cyclosporine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Testosterone (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Testosterone (Compound)
Cyclosporine (Compound) upregulates ST7 (Gene) and ST7 (Gene) is downregulated by Testosterone (Compound)
Cyclosporine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Testosterone (Compound)
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Estradiol (Compound) and Estradiol (Compound) resembles Testosterone (Compound)
Cyclosporine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Testosterone (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Testosterone (Compound)
Cyclosporine (Compound) upregulates ST7 (Gene) and ST7 (Gene) is downregulated by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Testosterone (Compound)
Cyclosporine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Estradiol (Compound) and Estradiol (Compound) resembles Testosterone (Compound)