DDInter596 DDInter987
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and cardiac output, without vasoconstriction.[A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline]. Isoprenaline was granted FDA approval on 19 February 1948.
Doxorubicin {u} (Compound) downregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Isoprenaline
Doxorubicin {u} (Compound) downregulates {v} (Gene) COG2
COG2 {u} (Gene) is downregulated by {v} (Compound) Isoprenaline
Doxorubicin {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Isoprenaline
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Doxorubicin {u} (Compound) downregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Methyldopa
Methyldopa {u} (Compound) resembles {v} (Compound) Isoprenaline
Doxorubicin {u} (Compound) downregulates {v} (Gene) COG2
COG2 {u} (Gene) is downregulated by {v} (Compound) Ephedrine
Ephedrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Doxorubicin {u} (Compound) downregulates {v} (Gene) DDX10
DDX10 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Isoprenaline
Doxorubicin {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) PIK3R1
PIK3R1 {u} (Gene) is bound by {v} (Compound) Isoprenaline
Doxorubicin {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Labetalol
Labetalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Doxorubicin (Compound) downregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Isoprenaline (Compound)
Doxorubicin (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Isoprenaline (Compound)
Doxorubicin (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Isoprenaline (Compound)
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Doxorubicin (Compound) downregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Methyldopa (Compound) and Methyldopa (Compound) resembles Isoprenaline (Compound)
Doxorubicin (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Ephedrine (Compound) and Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Doxorubicin (Compound) downregulates DDX10 (Gene) and DDX10 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Isoprenaline (Compound)
Doxorubicin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by PIK3R1 (Gene) and PIK3R1 (Gene) is bound by Isoprenaline (Compound)
Doxorubicin (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Labetalol (Compound) and Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline