DDInter31 DDInter1055
The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole] and [regadenson].[A229833,A229838] Adenosine is also indicated in the treatment of supraventricular tachycardia. Adenosine was granted FDA approval on 30 October 1989.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Adenosine {u} (Compound) causes {v} (Side Effect) Respiratory failure
Respiratory failure {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) causes {v} (Side Effect) Respiratory failure
Respiratory failure {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Adenosine {u} (Compound) causes {v} (Side Effect) Sensory loss
Sensory loss {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Azacitidine
Azacitidine {u} (Compound) binds {v} (Gene) DNMT3A
DNMT3A {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Azacitidine
Azacitidine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Glucosamine
Glucosamine {u} (Compound) downregulates {v} (Gene) PLEKHM1
PLEKHM1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Adenosine triphosphate
Adenosine triphosphate {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Azacitidine
Azacitidine {u} (Compound) upregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Nelarabine
Nelarabine {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Adenosine {u} (Compound) resembles {v} (Compound) Azacitidine
Azacitidine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Adenosine (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Levofloxacin (Compound)
Adenosine (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Adenosine (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Adenosine (Compound) resembles Azacitidine (Compound) and Azacitidine (Compound) binds DNMT3A (Gene) and DNMT3A (Gene) is downregulated by Levofloxacin (Compound)
Adenosine (Compound) resembles Azacitidine (Compound) and Azacitidine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)
Adenosine (Compound) resembles Glucosamine (Compound) and Glucosamine (Compound) downregulates PLEKHM1 (Gene) and PLEKHM1 (Gene) is downregulated by Levofloxacin (Compound)
Adenosine (Compound) resembles Adenosine triphosphate (Compound) and Adenosine triphosphate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Adenosine (Compound) resembles Azacitidine (Compound) and Azacitidine (Compound) upregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Levofloxacin (Compound)
Adenosine (Compound) resembles Nelarabine (Compound) and Nelarabine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Levofloxacin (Compound)
Adenosine (Compound) resembles Azacitidine (Compound) and Azacitidine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)