DDInter48 DDInter456
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout. It was initially approved by the FDA in 1966 and is now formulated by several manufacturers.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Allopurinol {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Mechlorethamine
Mechlorethamine {u} (Compound) resembles {v} (Compound) Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Norfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Infertility
Infertility {u} (Side Effect) is caused by {v} (Compound) Ganciclovir
Ganciclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Renal impairment
Renal impairment {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Indomethacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Water intoxication
Water intoxication {u} (Side Effect) is caused by {v} (Compound) Desmopressin
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Indomethacin
Indomethacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Disseminated intravascular coagulation
Disseminated intravascular coagulation {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Ganciclovir
Ganciclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Allopurinol {u} (Compound) causes {v} (Side Effect) Tumour lysis syndrome
Tumour lysis syndrome {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Cyclophosphamide
Allopurinol (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Cyclophosphamide (Compound)
Allopurinol (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Mechlorethamine (Compound) and Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Allopurinol (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Norfloxacin (Compound) and Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Cyclophosphamide
Allopurinol (Compound) causes Infertility (Side Effect) and Infertility (Side Effect) is caused by Ganciclovir (Compound) and Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide
Allopurinol (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Indomethacin (Compound) and Indomethacin may cause a minor interaction that can limit clinical effects when taken with Cyclophosphamide
Allopurinol (Compound) causes Water intoxication (Side Effect) and Water intoxication (Side Effect) is caused by Desmopressin (Compound) and Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is treated by Indomethacin (Compound) and Indomethacin may cause a minor interaction that can limit clinical effects when taken with Cyclophosphamide
Allopurinol (Compound) causes Disseminated intravascular coagulation (Side Effect) and Disseminated intravascular coagulation (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide (Compound) resembles Cyclophosphamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide
Allopurinol (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Ganciclovir (Compound) and Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide
Allopurinol (Compound) causes Tumour lysis syndrome (Side Effect) and Tumour lysis syndrome (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Cyclophosphamide