DDInter989 DDInter1376
A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Isosorbide dinitrate {u} (Compound) resembles {v} (Compound) Isosorbide mononitrate
Isosorbide dinitrate {u} (Compound) binds {v} (Gene) NPR1
Isosorbide dinitrate {u} (Compound) upregulates {v} (Gene) PROS1
Isosorbide dinitrate {u} (Compound) palliates {v} (Disease) coronary artery disease
Isosorbide dinitrate {u} (Compound) is included by {v} (Pharmacologic Class) Vasodilation
Isosorbide dinitrate {u} (Compound) downregulates {v} (Gene) NOSIP
Isosorbide dinitrate {u} (Compound) causes {v} (Side Effect) Dermatitis exfoliative
Isosorbide dinitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Isosorbide dinitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cocaine
Isosorbide dinitrate {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Isosorbide dinitrate (Compound) resembles Isosorbide mononitrate (Compound)
Isosorbide dinitrate (Compound) binds NPR1 (Gene)
Isosorbide dinitrate (Compound) upregulates PROS1 (Gene)
Isosorbide dinitrate (Compound) palliates coronary artery disease (Disease)
Isosorbide dinitrate (Compound) is included by Vasodilation (Pharmacologic Class)
Isosorbide dinitrate (Compound) downregulates NOSIP (Gene)
Isosorbide dinitrate (Compound) causes Dermatitis exfoliative (Side Effect)
Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Isosorbide dinitrate may lead to a major life threatening interaction when taken with Nitrous acid