DDInter1448 DDInter808
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including the treatment of hypertensive episodes, prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and treatment of pharmacologically-induced mydriasis.[L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and topically.
Garlic allergenic extract is used in allergenic testing.
Phentolamine {u} (Compound) resembles {v} (Compound) Naphazoline
Phentolamine {u} (Compound) resembles {v} (Compound) Antazoline
Phentolamine {u} (Compound) binds {v} (Gene) SIGMAR1
Phentolamine {u} (Compound) upregulates {v} (Gene) RAB4A
Phentolamine {u} (Compound) palliates {v} (Disease) hypertension
Phentolamine {u} (Compound) downregulates {v} (Gene) RPS4Y1
Phentolamine {u} (Compound) causes {v} (Side Effect) Tachycardia
Phentolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Insulin degludec
Phentolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Insulin human
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clozapine
Phentolamine (Compound) resembles Naphazoline (Compound)
Phentolamine (Compound) resembles Antazoline (Compound)
Phentolamine (Compound) binds SIGMAR1 (Gene)
Phentolamine (Compound) upregulates RAB4A (Gene)
Phentolamine (Compound) palliates hypertension (Disease)
Phentolamine (Compound) downregulates RPS4Y1 (Gene)
Phentolamine (Compound) causes Tachycardia (Side Effect)
Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin human
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine