DDInter1619 DDInter1793
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Ropinirole {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sucralfate
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sotalol
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Pregabalin
Pregabalin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) causes {v} (Side Effect) Fluid overload
Fluid overload {u} (Side Effect) is caused by {v} (Compound) Potassium chloride
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Tramadol
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Nicardipine
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trospium
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) is upregulated by {v} (Compound) Nicardipine
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Nicardipine
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) is upregulated by {v} (Compound) Olanzapine
Olanzapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Ropinirole (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sucralfate (Compound) and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Ropinirole (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Ropinirole (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Pregabalin (Compound) and Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Ropinirole (Compound) causes Fluid overload (Side Effect) and Fluid overload (Side Effect) is caused by Potassium chloride (Compound) and Potassium chloride may lead to a major life threatening interaction when taken with Thiethylperazine
Ropinirole (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Tramadol (Compound) and Tramadol may lead to a major life threatening interaction when taken with Thiethylperazine
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trospium (Compound) and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Ropinirole (Compound) upregulates NNT (Gene) and NNT (Gene) is upregulated by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Ropinirole (Compound) upregulates NNT (Gene) and NNT (Gene) is upregulated by Olanzapine (Compound) and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine