DDInter1887 DDInter1082
Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones. Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Trovafloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
Trovafloxacin {u} (Compound) causes {v} (Side Effect) Encephalopathy
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxyurea
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mitomycin
Trovafloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Trovafloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegaspargase
Trovafloxacin {u} may lead to a major life threatening interaction when taken with {v} Acetohexamide
Trovafloxacin {u} may lead to a major life threatening interaction when taken with {v} Nateglinide
Trovafloxacin (Compound) resembles Gemifloxacin (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene)
Trovafloxacin (Compound) causes Encephalopathy (Side Effect)
Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Hydroxyurea
Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Mitomycin
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase
Trovafloxacin may lead to a major life threatening interaction when taken with Acetohexamide
Trovafloxacin may lead to a major life threatening interaction when taken with Nateglinide