DDInter458 DDInter1559
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Thrombosis
Thrombosis {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Psoriasis
Psoriasis {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rabeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Coma
Coma {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rabeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cellulitis
Cellulitis {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Ponatinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rabeprazole
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rabeprazole (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Rabeprazole (Compound)
Cyclosporine (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Rabeprazole (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Esomeprazole (Compound) and Esomeprazole (Compound) resembles Rabeprazole (Compound)
Cyclosporine (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Cyclosporine (Compound) causes Thrombosis (Side Effect) and Thrombosis (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Rabeprazole (Compound)
Cyclosporine (Compound) causes Psoriasis (Side Effect) and Psoriasis (Side Effect) is caused by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole
Cyclosporine (Compound) causes Coma (Side Effect) and Coma (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Rabeprazole
Cyclosporine (Compound) causes Cellulitis (Side Effect) and Cellulitis (Side Effect) is caused by Ponatinib (Compound) and Ponatinib may cause a minor interaction that can limit clinical effects when taken with Rabeprazole