DDInter458 DDInter783
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Fosphenytoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Fosphenytoin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fosphenytoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Fosphenytoin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fosphenytoin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Methylphenobarbital
Methylphenobarbital {u} (Compound) resembles {v} (Compound) Fosphenytoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Clopidogrel
Clopidogrel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fosphenytoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tingling sensation
Tingling sensation {u} (Side Effect) is caused by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Doxapram
Doxapram {u} (Compound) resembles {v} (Compound) Fosphenytoin
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fosphenytoin (Compound)
Cyclosporine (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Fosphenytoin (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Modafinil (Compound) and Modafinil (Compound) resembles Fosphenytoin (Compound)
Cyclosporine (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Fosphenytoin
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Methylphenobarbital (Compound) and Methylphenobarbital (Compound) resembles Fosphenytoin (Compound)
Cyclosporine (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Cyclosporine (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Clopidogrel (Compound) and Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Fosphenytoin
Cyclosporine (Compound) causes Tingling sensation (Side Effect) and Tingling sensation (Side Effect) is caused by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Cyclosporine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Doxapram (Compound) and Doxapram (Compound) resembles Fosphenytoin (Compound)