DDInter542 DDInter1397
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is regulated by {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) resembles {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) binds {v} (Gene) GPR35
GPR35 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) resembles {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dicoumarol {u} (Compound) binds {v} (Gene) GPR35
GPR35 {u} (Gene) regulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Dicoumarol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Paroxetine (Compound)
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Dicoumarol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Dicoumarol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is regulated by LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Dicoumarol (Compound) resembles Acenocoumarol (Compound) and Acenocoumarol (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Paroxetine (Compound)
Dicoumarol (Compound) binds GPR35 (Gene) and GPR35 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Paroxetine (Compound)
Dicoumarol (Compound) resembles Acenocoumarol (Compound) and Acenocoumarol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Paroxetine (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Paroxetine (Compound)
Dicoumarol (Compound) binds GPR35 (Gene) and GPR35 (Gene) regulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)