DDInter1042 DDInter212
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Bisacodyl {u} (Compound) resembles {v} (Compound) Carbinoxamine
Bisacodyl {u} (Compound) resembles {v} (Compound) Dexbrompheniramine
Bisacodyl {u} (Compound) binds {v} (Gene) GPR55
Bisacodyl {u} (Compound) upregulates {v} (Gene) KTN1
Bisacodyl {u} (Compound) is included by {v} (Pharmacologic Class) Stimulation Large Intestine Fluid/Electrolyte Secretion
Bisacodyl {u} (Compound) downregulates {v} (Gene) MTMR4
Bisacodyl {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Bisacodyl {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomefloxacin
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pitolisant
Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Bisacodyl (Compound) resembles Dexbrompheniramine (Compound)
Bisacodyl (Compound) binds GPR55 (Gene)
Bisacodyl (Compound) upregulates KTN1 (Gene)
Bisacodyl (Compound) is included by Stimulation Large Intestine Fluid/Electrolyte Secretion (Pharmacologic Class)
Bisacodyl (Compound) downregulates MTMR4 (Gene)
Bisacodyl (Compound) causes Nervous system disorder (Side Effect)
Bisacodyl may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant