DDInter1768 DDInter740
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.
Terbinafine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Flecainide
Terbinafine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Flecainide
Terbinafine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Terbinafine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Terbinafine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Terbinafine {u} (Compound) downregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is downregulated by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Terbinafine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Flecainide
Terbinafine {u} (Compound) downregulates {v} (Gene) RRP12
RRP12 {u} (Gene) regulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Flecainide
Terbinafine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Flecainide
Terbinafine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is regulated by {v} (Gene) SUPV3L1
SUPV3L1 {u} (Gene) is downregulated by {v} (Compound) Flecainide
Terbinafine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Flecainide (Compound)
Terbinafine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Flecainide (Compound)
Terbinafine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Terbinafine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Terbinafine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Terbinafine (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Terbinafine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Flecainide (Compound)
Terbinafine (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) regulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Flecainide (Compound)
Terbinafine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Flecainide (Compound)
Terbinafine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is regulated by SUPV3L1 (Gene) and SUPV3L1 (Gene) is downregulated by Flecainide (Compound)