DDInter459 DDInter1960
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Cyproheptadine {u} (Compound) resembles {v} (Compound) Metixene
Cyproheptadine {u} (Compound) resembles {v} (Compound) Nortriptyline
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Protriptyline
Cyproheptadine {u} (Compound) treats {v} (Disease) allergic rhinitis
Cyproheptadine {u} (Compound) binds {v} (Gene) UGT1A3
Cyproheptadine {u} (Compound) upregulates {v} (Gene) KAT6A
Cyproheptadine {u} (Compound) palliates {v} (Disease) migraine
Cyproheptadine {u} (Compound) downregulates {v} (Gene) RPA1
Cyproheptadine {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Cyproheptadine (Compound) resembles Metixene (Compound)
Cyproheptadine (Compound) resembles Nortriptyline (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline
Cyproheptadine (Compound) treats allergic rhinitis (Disease)
Cyproheptadine (Compound) binds UGT1A3 (Gene)
Cyproheptadine (Compound) upregulates KAT6A (Gene)
Cyproheptadine (Compound) palliates migraine (Disease)
Cyproheptadine (Compound) downregulates RPA1 (Gene)
Cyproheptadine (Compound) causes Agranulocytosis (Side Effect)