DDInter1543 DDInter576
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, alpha<sub>1</sub
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Protriptyline {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is regulated by {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is regulated by {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) downregulates {v} (Gene) SMNDC1
SMNDC1 {u} (Gene) regulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Protriptyline {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) regulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Protriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Terbinafine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Protriptyline (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Disulfiram (Compound)
Protriptyline (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Disulfiram (Compound)
Protriptyline (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Disulfiram (Compound)
Protriptyline (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is regulated by MOK (Gene) and MOK (Gene) is upregulated by Disulfiram (Compound)
Protriptyline (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is regulated by NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Protriptyline (Compound) downregulates SMNDC1 (Gene) and SMNDC1 (Gene) regulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Disulfiram (Compound)
Protriptyline (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Protriptyline (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Protriptyline (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) regulates RELB (Gene) and RELB (Gene) is upregulated by Disulfiram (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine and Terbinafine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)