DDInter596 DDInter45
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
A phenothiazine derivative that is used as an antipruritic.
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) CHEK2
CHEK2 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) binds {v} (Gene) DHCR7
DHCR7 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) COG2
COG2 {u} (Gene) is downregulated by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) CHEK2
CHEK2 {u} (Gene) regulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) resembles {v} (Compound) Alimemazine
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alimemazine (Compound)
Doxorubicin (Compound) downregulates CHEK2 (Gene) and CHEK2 (Gene) is upregulated by Alimemazine (Compound)
Doxorubicin (Compound) binds DHCR7 (Gene) and DHCR7 (Gene) is upregulated by Alimemazine (Compound)
Doxorubicin (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Alimemazine (Compound)
Doxorubicin (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Alimemazine (Compound)
Doxorubicin (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Alimemazine (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Doxorubicin (Compound) downregulates CHEK2 (Gene) and CHEK2 (Gene) regulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Alimemazine (Compound)
Doxorubicin (Compound) downregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Alimemazine (Compound)