DDInter150 DDInter292
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Azathioprine {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Captopril
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Captopril
Azathioprine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Captopril
Azathioprine {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Captopril
Azathioprine {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is associated with {v} (Gene) MMP2
MMP2 {u} (Gene) is bound by {v} (Compound) Captopril
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Captopril
Azathioprine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) regulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Captopril
Azathioprine {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Captopril
Azathioprine {u} (Compound) causes {v} (Side Effect) Cholestasis
Cholestasis {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Tioguanine
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Azathioprine (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Captopril (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Captopril (Compound)
Azathioprine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Captopril (Compound)
Azathioprine (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Captopril (Compound)
Azathioprine (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is associated with MMP2 (Gene) and MMP2 (Gene) is bound by Captopril (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Captopril (Compound)
Azathioprine (Compound) downregulates CYCS (Gene) and CYCS (Gene) regulates RELB (Gene) and RELB (Gene) is upregulated by Captopril (Compound)
Azathioprine (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Captopril (Compound)
Azathioprine (Compound) causes Cholestasis (Side Effect) and Cholestasis (Side Effect) is caused by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Captopril
Azathioprine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Tioguanine (Compound) and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Captopril