DDInter557 DDInter985
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches.
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Isometheptene
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} (Compound) binds {v} (Gene) ADRA1A
ADRA1A {u} (Gene) is bound by {v} (Compound) Isometheptene
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) IPO13
IPO13 {u} (Gene) regulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Isometheptene
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isometheptene
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Isometheptene
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Phenylpropanolamine
Phenylpropanolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isometheptene
Dihydroergotamine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is upregulated by {v} (Compound) Isometheptene
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Methylene blue {u} may lead to a major life threatening interaction when taken with {v} Isometheptene
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) TNFRSF21
TNFRSF21 {u} (Gene) regulates {v} (Gene) RUVBL1
RUVBL1 {u} (Gene) is downregulated by {v} (Compound) Isometheptene
Dihydroergotamine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Reserpine
Reserpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isometheptene
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Isometheptene
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Isometheptene (Compound)
Dihydroergotamine (Compound) downregulates IPO13 (Gene) and IPO13 (Gene) regulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Isometheptene (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Dihydroergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Isometheptene (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Phenylpropanolamine and Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Dihydroergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Isometheptene (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Methylene blue and Methylene blue may lead to a major life threatening interaction when taken with Isometheptene
Dihydroergotamine (Compound) downregulates TNFRSF21 (Gene) and TNFRSF21 (Gene) regulates RUVBL1 (Gene) and RUVBL1 (Gene) is downregulated by Isometheptene (Compound)
Dihydroergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Reserpine (Compound) and Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene