DDInter1164 DDInter1867
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. Another well-known benefit of this drug is modest weight loss, making it an effective choice for obese patients type II diabetes. Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the US in 1995.
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Triflupromazine
Metformin {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Triflupromazine
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Ethopropazine
Ethopropazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Desipramine
Desipramine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Ethopropazine
Ethopropazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} (Compound) binds {v} (Gene) SLC22A1
SLC22A1 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Mequitazine
Mequitazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Methdilazine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Triflupromazine (Compound)
Metformin (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Triflupromazine (Compound)
Metformin (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Triflupromazine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Pipotiazine (Compound) and Pipotiazine (Compound) resembles Triflupromazine (Compound)
Metformin (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Ethopropazine (Compound) and Ethopropazine (Compound) resembles Triflupromazine (Compound)
Metformin (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Desipramine (Compound) and Desipramine (Compound) resembles Triflupromazine (Compound)
Metformin (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Ethopropazine (Compound) and Ethopropazine (Compound) resembles Triflupromazine (Compound)
Metformin (Compound) binds SLC22A1 (Gene) and SLC22A1 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Triflupromazine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Mequitazine (Compound) and Mequitazine (Compound) resembles Triflupromazine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Perphenazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Triflupromazine (Compound)