DDInter1300 DDInter119
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nitisinone {u} (Compound) binds {v} (Gene) HPD
Nitisinone {u} (Compound) is included by {v} (Pharmacologic Class) Hydroxyphenylpyruvate Dioxygenase Inhibitors
Nitisinone {u} (Compound) causes {v} (Side Effect) Rash erythematous
Nitisinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Netupitant
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Butalbital
Nitisinone (Compound) resembles Flutamide (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound)
Nitisinone (Compound) binds HPD (Gene)
Nitisinone (Compound) is included by Hydroxyphenylpyruvate Dioxygenase Inhibitors (Pharmacologic Class)
Nitisinone (Compound) causes Rash erythematous (Side Effect)
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Netupitant
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Butalbital