DDInter1177 DDInter1853
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Methoxsalen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Methoxsalen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acitretin
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Methoxsalen {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Tretinoin
Methoxsalen {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Methoxsalen {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Methoxsalen {u} (Compound) causes {v} (Side Effect) Sunburn
Sunburn {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Methoxsalen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Methoxsalen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Methoxsalen {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Methoxsalen {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin (Compound) resembles Tretinoin (Compound)
Methoxsalen (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Tretinoin (Compound)
Methoxsalen (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Tretinoin (Compound)
Methoxsalen (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Tretinoin (Compound)
Methoxsalen (Compound) causes Sunburn (Side Effect) and Sunburn (Side Effect) is caused by Tretinoin (Compound)
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Methoxsalen (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Methoxsalen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)