DDInter535 DDInter981
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.
Diazoxide {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Lacosamide
Lacosamide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Lacosamide
Lacosamide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) downregulates {v} (Gene) TIMP1
TIMP1 {u} (Gene) is regulated by {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) upregulates {v} (Gene) MAP7
MAP7 {u} (Gene) is regulated by {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) upregulates {v} (Gene) MAP7
MAP7 {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) downregulates {v} (Gene) ACD
ACD {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Diazoxide (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)
Diazoxide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Isocarboxazid (Compound)
Diazoxide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Lacosamide (Compound) and Lacosamide (Compound) resembles Isocarboxazid (Compound)
Diazoxide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Lacosamide (Compound) and Lacosamide (Compound) resembles Isocarboxazid (Compound)
Diazoxide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Metamfetamine (Compound) and Metamfetamine (Compound) resembles Isocarboxazid (Compound)
Diazoxide (Compound) downregulates TIMP1 (Gene) and TIMP1 (Gene) is regulated by MAOB (Gene) and MAOB (Gene) is bound by Isocarboxazid (Compound)
Diazoxide (Compound) upregulates MAP7 (Gene) and MAP7 (Gene) is regulated by MAOB (Gene) and MAOB (Gene) is bound by Isocarboxazid (Compound)
Diazoxide (Compound) upregulates MAP7 (Gene) and MAP7 (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)
Diazoxide (Compound) downregulates ACD (Gene) and ACD (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)