DDInter45 DDInter1747
A phenothiazine derivative that is used as an antipruritic.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Alimemazine {u} (Compound) resembles {v} (Compound) Acetophenazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orphenadrine
Alimemazine {u} (Compound) resembles {v} (Compound) Pheniramine
Alimemazine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Alimemazine {u} (Compound) binds {v} (Gene) CYP3A4
Alimemazine {u} (Compound) upregulates {v} (Gene) CHEK2
Alimemazine {u} (Compound) downregulates {v} (Gene) PDHX
Alimemazine {u} (Compound) causes {v} (Side Effect) Respiratory depression
Alimemazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Alimemazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Alimemazine (Compound) resembles Acetophenazine (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine
Alimemazine (Compound) resembles Pheniramine (Compound)
Alimemazine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Alimemazine (Compound) binds CYP3A4 (Gene)
Alimemazine (Compound) upregulates CHEK2 (Gene)
Alimemazine (Compound) downregulates PDHX (Gene)
Alimemazine (Compound) causes Respiratory depression (Side Effect)
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate