DDInter147 DDInter1435
Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation VEGFR inhibitors. Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Axitinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lansoprazole
Axitinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium citrate
Axitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epirubicin
Axitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Netupitant
Axitinib {u} may lead to a major life threatening interaction when taken with {v} Atazanavir
Axitinib {u} may lead to a major life threatening interaction when taken with {v} Lomitapide
Axitinib may cause a minor interaction that can limit clinical effects when taken with Lansoprazole
Axitinib may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin
Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Netupitant
Axitinib may lead to a major life threatening interaction when taken with Atazanavir
Axitinib may lead to a major life threatening interaction when taken with Lomitapide