DDInter458 DDInter1881
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Zaleplon
Zaleplon {u} may cause a minor interaction that can limit clinical effects when taken with {v} Troglitazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Troglitazone
Cyclosporine {u} (Compound) upregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Zaleplon
Zaleplon {u} may cause a minor interaction that can limit clinical effects when taken with {v} Troglitazone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Zaleplon
Zaleplon {u} may cause a minor interaction that can limit clinical effects when taken with {v} Troglitazone
Cyclosporine {u} (Compound) upregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Dextromethorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Troglitazone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Goserelin
Goserelin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Troglitazone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Etacrynic acid
Etacrynic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Troglitazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Troglitazone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Lymphadenopathy
Lymphadenopathy {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Troglitazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Lomitapide
Lomitapide {u} may lead to a major life threatening interaction when taken with {v} Troglitazone
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Zaleplon (Compound) and Zaleplon may cause a minor interaction that can limit clinical effects when taken with Troglitazone
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Dextromethorphan (Compound) and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone
Cyclosporine (Compound) upregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Zaleplon (Compound) and Zaleplon may cause a minor interaction that can limit clinical effects when taken with Troglitazone
Cyclosporine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Zaleplon (Compound) and Zaleplon may cause a minor interaction that can limit clinical effects when taken with Troglitazone
Cyclosporine (Compound) upregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Dextromethorphan (Compound) and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone
Cyclosporine (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Goserelin (Compound) and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone
Cyclosporine (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Etacrynic acid (Compound) and Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone
Cyclosporine (Compound) causes Lymphadenopathy (Side Effect) and Lymphadenopathy (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Troglitazone
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound) and Lomitapide may lead to a major life threatening interaction when taken with Troglitazone