DDInter255 DDInter1705
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Busulfan {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Sparfloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) WRB
WRB {u} (Gene) is upregulated by {v} (Compound) Sparfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) WRB
WRB {u} (Gene) is regulated by {v} (Gene) PHKA1
PHKA1 {u} (Gene) is downregulated by {v} (Compound) Sparfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Atrioventricular block complete
Atrioventricular block complete {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Sparfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Atrioventricular block complete
Atrioventricular block complete {u} (Side Effect) is caused by {v} (Compound) Fingolimod
Fingolimod {u} may lead to a major life threatening interaction when taken with {v} Sparfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Skin discolouration
Skin discolouration {u} (Side Effect) is caused by {v} (Compound) Etoposide
Etoposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Busulfan (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Sparfloxacin (Compound)
Busulfan (Compound) downregulates WRB (Gene) and WRB (Gene) is upregulated by Sparfloxacin (Compound)
Busulfan (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Sparfloxacin (Compound)
Busulfan (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Busulfan (Compound) downregulates WRB (Gene) and WRB (Gene) is regulated by PHKA1 (Gene) and PHKA1 (Gene) is downregulated by Sparfloxacin (Compound)
Busulfan (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Busulfan (Compound) causes Atrioventricular block complete (Side Effect) and Atrioventricular block complete (Side Effect) is caused by Paclitaxel (Compound) and Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Sparfloxacin
Busulfan (Compound) causes Atrioventricular block complete (Side Effect) and Atrioventricular block complete (Side Effect) is caused by Fingolimod (Compound) and Fingolimod may lead to a major life threatening interaction when taken with Sparfloxacin
Busulfan (Compound) causes Skin discolouration (Side Effect) and Skin discolouration (Side Effect) is caused by Etoposide (Compound) and Etoposide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin