DDInter702 DDInter1956
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etoposide {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Etoposide {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Zalcitabine
Etoposide {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Etoposide {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Etoposide {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Etoposide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etoposide {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Etoposide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Zalcitabine (Compound)
Etoposide (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Zalcitabine (Compound)
Etoposide (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Zalcitabine (Compound)
Etoposide (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Zalcitabine (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Etoposide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Zalcitabine (Compound)
Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cytarabine (Compound) and Cytarabine (Compound) resembles Zalcitabine (Compound)
Etoposide (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)