DDInter596 DDInter1553
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) upregulates {v} (Gene) PTPN6
PTPN6 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Salivary hypersecretion
Salivary hypersecretion {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quetiapine
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trazodone
Trazodone {u} (Compound) resembles {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is regulated by {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) upregulates {v} (Gene) PTPN6
PTPN6 {u} (Gene) regulates {v} (Gene) CASC3
CASC3 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Doxorubicin {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) is regulated by {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Quetiapine
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Quetiapine (Compound)
Doxorubicin (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Quetiapine (Compound)
Doxorubicin (Compound) upregulates PTPN6 (Gene) and PTPN6 (Gene) is upregulated by Quetiapine (Compound)
Doxorubicin (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Quetiapine (Compound)
Doxorubicin (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Quetiapine (Compound)
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trazodone (Compound) and Trazodone (Compound) resembles Quetiapine (Compound)
Doxorubicin (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is regulated by HTR2C (Gene) and HTR2C (Gene) is bound by Quetiapine (Compound)
Doxorubicin (Compound) upregulates PTPN6 (Gene) and PTPN6 (Gene) regulates CASC3 (Gene) and CASC3 (Gene) is upregulated by Quetiapine (Compound)
Doxorubicin (Compound) upregulates RELB (Gene) and RELB (Gene) is regulated by HTR2C (Gene) and HTR2C (Gene) is bound by Quetiapine (Compound)