DDInter381 DDInter504
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
Cinacalcet {u} (Compound) resembles {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Desipramine
Cinacalcet {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Desipramine
Cinacalcet {u} (Compound) resembles {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) resembles {v} (Compound) Demexiptiline
Demexiptiline {u} (Compound) resembles {v} (Compound) Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Aprindine
Aprindine {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) causes {v} (Side Effect) Depression
Depression {u} (Side Effect) is caused by {v} (Compound) Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Demexiptiline
Demexiptiline {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Cinacalcet (Compound) resembles Triflupromazine (Compound) and Triflupromazine (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Desipramine (Compound)
Cinacalcet (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Desipramine (Compound)
Cinacalcet (Compound) resembles Triflupromazine (Compound) and Triflupromazine (Compound) resembles Promazine (Compound) and Promazine (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) resembles Demexiptiline (Compound) and Demexiptiline (Compound) resembles Protriptyline (Compound) and Protriptyline (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Aprindine (Compound) and Aprindine (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Protriptyline (Compound) and Protriptyline (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) causes Depression (Side Effect) and Depression (Side Effect) is caused by Atomoxetine (Compound) and Atomoxetine (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Demexiptiline (Compound) and Demexiptiline (Compound) resembles Desipramine (Compound)
Cinacalcet (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Protriptyline (Compound) and Protriptyline (Compound) resembles Desipramine (Compound)