DDInter11 DDInter1763
Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are responsible for the metabolism of complex starches and oligo-, tri-, and disaccharides into absorbable simple sugars.[L31633,A37868] By inhibiting the activity of these enzymes, acarbose limits the absorption of dietary carbohydrates and the subsequent postprandial increase in blood glucose and insulin levels. Acarbose is therefore used in conjunction with diet, exercise, and other pharmacotherapies for the management of blood sugar levels in patients with type 2 diabetes.[L31628,L31633] Acarbose is one of only two approved alpha-glucosidase inhibitors (the other being
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Acarbose {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Acarbose {u} (Compound) causes {v} (Side Effect) Intestinal perforation
Intestinal perforation {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Acarbose {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) interacts with {v} (Gene) SETDB1
SETDB1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Acarbose {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Acarbose {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Acarbose {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is regulated by {v} (Gene) CTNND1
CTNND1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Acarbose {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Neomycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Acarbose (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Temsirolimus (Compound)
Acarbose (Compound) causes Intestinal perforation (Side Effect) and Intestinal perforation (Side Effect) is caused by Temsirolimus (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Acarbose (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) interacts with SETDB1 (Gene) and SETDB1 (Gene) is upregulated by Temsirolimus (Compound)
Acarbose (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Acarbose (Compound) resembles Amikacin (Compound) and Amikacin (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Temsirolimus (Compound)
Acarbose (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is regulated by CTNND1 (Gene) and CTNND1 (Gene) is upregulated by Temsirolimus (Compound)
Acarbose (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Temsirolimus (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Temsirolimus (Compound)