DDInter1465 DDInter1676
A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by pilocarpine dates back to 1875.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Pilocarpine {u} (Compound) treats {v} (Disease) glaucoma
Pilocarpine {u} (Compound) binds {v} (Gene) CHRM1
Pilocarpine {u} (Compound) upregulates {v} (Gene) PRKX
Pilocarpine {u} (Compound) palliates {v} (Disease) head and neck cancer
Pilocarpine {u} (Compound) is included by {v} (Pharmacologic Class) Cholinergic Muscarinic Agonists
Pilocarpine {u} (Compound) downregulates {v} (Gene) DLD
Pilocarpine {u} (Compound) causes {v} (Side Effect) Eye disorder
Pilocarpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dicyclomine
Pilocarpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aclidinium
Pilocarpine (Compound) treats glaucoma (Disease)
Pilocarpine (Compound) binds CHRM1 (Gene)
Pilocarpine (Compound) upregulates PRKX (Gene)
Pilocarpine (Compound) palliates head and neck cancer (Disease)
Pilocarpine (Compound) is included by Cholinergic Muscarinic Agonists (Pharmacologic Class)
Pilocarpine (Compound) downregulates DLD (Gene)
Pilocarpine (Compound) causes Eye disorder (Side Effect)
Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine
Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium