DDInter412 DDInter690
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Clonidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Lidocaine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} (Compound) resembles {v} (Compound) Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) CYP4A11
CYP4A11 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Doxepin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} (Compound) palliates {v} (Disease) autistic disorder
autistic disorder {u} (Disease) is associated with {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine {u} (Compound) downregulates {v} (Gene) ADM
ADM {u} (Gene) is regulated by {v} (Gene) GRIN3A
GRIN3A {u} (Gene) is bound by {v} (Compound) Ethanol
Clonidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Clonidine may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Clonidine (Compound) resembles Diclofenac (Compound) and Diclofenac (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Clonidine (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with CYP4A11 (Gene) and CYP4A11 (Gene) is bound by Ethanol (Compound)
Clonidine may lead to a major life threatening interaction when taken with Doxepin and Doxepin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Clonidine (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Ethanol (Compound)
Clonidine (Compound) palliates autistic disorder (Disease) and autistic disorder (Disease) is associated with GABRA1 (Gene) and GABRA1 (Gene) is bound by Ethanol (Compound)
Clonidine (Compound) downregulates ADM (Gene) and ADM (Gene) is regulated by GRIN3A (Gene) and GRIN3A (Gene) is bound by Ethanol (Compound)