DDInter38 DDInter675
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisoprolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisoprolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Metipranolol
Metipranolol {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Penbutolol
Penbutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisoprolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) downregulates {v} (Gene) PIN1
PIN1 {u} (Gene) is downregulated by {v} (Compound) Esmolol
Aldesleukin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioxilan
Ioxilan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisoprolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Esmolol
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Metipranolol (Compound) and Metipranolol (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Compound) resembles Ibuprofen (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) downregulates PIN1 (Gene) and PIN1 (Gene) is downregulated by Esmolol (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan and Ioxilan may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Esmolol (Compound)