DDInter1460 DDInter1340
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.[A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects.[A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs . Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Omeprazole
Phenytoin {u} (Compound) causes {v} (Side Effect) Gynaecomastia
Gynaecomastia {u} (Side Effect) is caused by {v} (Compound) Omeprazole
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} (Compound) causes {v} (Side Effect) Gynaecomastia
Gynaecomastia {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} (Compound) causes {v} (Side Effect) Tongue oedema
Tongue oedema {u} (Side Effect) is caused by {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) is downregulated by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Rabeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Omeprazole (Compound)
Phenytoin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Omeprazole (Compound)
Phenytoin (Compound) causes Gynaecomastia (Side Effect) and Gynaecomastia (Side Effect) is caused by Omeprazole (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Phenytoin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Omeprazole (Compound)
Phenytoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Phenytoin (Compound) causes Gynaecomastia (Side Effect) and Gynaecomastia (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Phenytoin (Compound) causes Tongue oedema (Side Effect) and Tongue oedema (Side Effect) is caused by Esomeprazole (Compound) and Esomeprazole (Compound) resembles Omeprazole (Compound)
Phenytoin (Compound) downregulates CAST (Gene) and CAST (Gene) is downregulated by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole (Compound) resembles Omeprazole (Compound)