DDInter1717 DDInter1008
Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances [A177655, F4519]. Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076].
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Sucralfate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Sucralfate {u} (Compound) binds {v} (Gene) FGG
FGG {u} (Gene) regulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) is downregulated by {v} (Compound) Ketoconazole
Sucralfate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Sucralfate {u} (Compound) binds {v} (Gene) EGF
EGF {u} (Gene) is regulated by {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Sucralfate {u} (Compound) binds {v} (Gene) FGA
FGA {u} (Gene) regulates {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Sucralfate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sotalol
Sotalol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acebutolol
Acebutolol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Alimemazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pindolol
Pindolol {u} (Compound) upregulates {v} (Gene) CYP1B1
CYP1B1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Sucralfate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Ketoconazole (Compound)
Sucralfate (Compound) binds FGG (Gene) and FGG (Gene) regulates PPP2R3C (Gene) and PPP2R3C (Gene) is downregulated by Ketoconazole (Compound)
Sucralfate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Sucralfate (Compound) binds EGF (Gene) and EGF (Gene) is regulated by ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Ketoconazole (Compound)
Sucralfate (Compound) binds FGA (Gene) and FGA (Gene) regulates ALDOC (Gene) and ALDOC (Gene) is upregulated by Ketoconazole (Compound)
Sucralfate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Sotalol and Sotalol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ketoconazole (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ketoconazole (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Posaconazole and Posaconazole (Compound) resembles Ketoconazole (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Pindolol and Pindolol (Compound) upregulates CYP1B1 (Gene) and CYP1B1 (Gene) is bound by Ketoconazole (Compound)