DDInter576 DDInter183
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Pitavastatin
Pitavastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is upregulated by {v} (Compound) Pitavastatin
Pitavastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) downregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is upregulated by {v} (Compound) Pitavastatin
Pitavastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) upregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) downregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Amprenavir
Amprenavir {u} may lead to a major life threatening interaction when taken with {v} Benznidazole
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Pitavastatin
Pitavastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) Ixabepilone
Ixabepilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benznidazole
Disulfiram {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Amprenavir
Amprenavir {u} may lead to a major life threatening interaction when taken with {v} Benznidazole
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Pitavastatin (Compound) and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Pitavastatin (Compound) and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) downregulates DDB2 (Gene) and DDB2 (Gene) is upregulated by Pitavastatin (Compound) and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) upregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) downregulates DDB2 (Gene) and DDB2 (Gene) is downregulated by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Amprenavir (Compound) and Amprenavir may lead to a major life threatening interaction when taken with Benznidazole
Disulfiram (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Pitavastatin (Compound) and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Ixabepilone (Compound) and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Vinblastine (Compound) and TUBB6 (Gene) is upregulated by Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Disulfiram (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Amprenavir (Compound) and Amprenavir may lead to a major life threatening interaction when taken with Benznidazole