DDInter1355 DDInter434
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The
Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistin
Colistin {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistin
Colistin {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) is included by {v} (Pharmacologic Class) Polymyxins
Polymyxins {u} (Pharmacologic Class) includes {v} (Compound) Colistimethate
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vancomycin
Vancomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Colistin (Compound) and Colistin (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistin (Compound) and Colistin (Compound) resembles Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) is included by Polymyxins (Pharmacologic Class) and Polymyxins (Pharmacologic Class) includes Colistimethate (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)