DDInter993 DDInter278
Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Isradipine {u} (Compound) resembles {v} (Compound) Amlodipine
Isradipine {u} (Compound) resembles {v} (Compound) Nimodipine
Isradipine {u} (Compound) treats {v} (Disease) hypertension
Isradipine {u} (Compound) binds {v} (Gene) CYP3A4
Isradipine {u} (Compound) upregulates {v} (Gene) KLHL21
Isradipine {u} (Compound) is included by {v} (Pharmacologic Class) Dihydropyridines
Isradipine {u} (Compound) downregulates {v} (Gene) MT2A
Isradipine {u} (Compound) causes {v} (Side Effect) Visual impairment
Isradipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Simvastatin
Isradipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tocilizumab
Isradipine (Compound) resembles Amlodipine (Compound)
Isradipine (Compound) resembles Nimodipine (Compound)
Isradipine (Compound) treats hypertension (Disease)
Isradipine (Compound) binds CYP3A4 (Gene)
Isradipine (Compound) upregulates KLHL21 (Gene)
Isradipine (Compound) is included by Dihydropyridines (Pharmacologic Class)
Isradipine (Compound) downregulates MT2A (Gene)
Isradipine (Compound) causes Visual impairment (Side Effect)
Isradipine may cause a minor interaction that can limit clinical effects when taken with Simvastatin
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab