DDInter1867 DDInter1024
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1) tyrosine kinases inhibitor. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Lapatinib
Triflupromazine {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is upregulated by {v} (Compound) Lapatinib
Triflupromazine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Lapatinib
Triflupromazine {u} (Compound) resembles {v} (Compound) Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lapatinib
Triflupromazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lapatinib
Triflupromazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Lapatinib
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Lapatinib
Triflupromazine {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Lapatinib
Triflupromazine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) VAV3
VAV3 {u} (Gene) is upregulated by {v} (Compound) Lapatinib
Triflupromazine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) TAP1
TAP1 {u} (Gene) is bound by {v} (Compound) Lapatinib
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Triflupromazine (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is upregulated by Lapatinib (Compound)
Triflupromazine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Lapatinib (Compound)
Triflupromazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib
Triflupromazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib
Triflupromazine (Compound) resembles Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Lapatinib
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Triflupromazine (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Triflupromazine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by VAV3 (Gene) and VAV3 (Gene) is upregulated by Lapatinib (Compound)
Triflupromazine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by TAP1 (Gene) and TAP1 (Gene) is bound by Lapatinib (Compound)