DDInter1055 DDInter1160
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Levofloxacin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Mestranol
Levofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Mestranol
Levofloxacin {u} (Compound) downregulates {v} (Gene) ASS1
ASS1 {u} (Gene) is downregulated by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Mestranol
Levofloxacin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) resembles {v} (Compound) Mestranol
Levofloxacin {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Acute coronary syndrome {u} (Side Effect) is caused by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Mestranol
Levofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) ESR1
ESR1 {u} (Gene) is bound by {v} (Compound) Mestranol
Levofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Mestranol
Levofloxacin {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Acute coronary syndrome {u} (Side Effect) is caused by {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) resembles {v} (Compound) Mestranol
Levofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) regulates {v} (Gene) HSD17B10
HSD17B10 {u} (Gene) is downregulated by {v} (Compound) Mestranol
Levofloxacin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mestranol
Levofloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Norethisterone (Compound) and Norethisterone (Compound) resembles Mestranol (Compound)
Levofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Norethisterone (Compound) and Norethisterone (Compound) resembles Mestranol (Compound)
Levofloxacin (Compound) downregulates ASS1 (Gene) and ASS1 (Gene) is downregulated by Norethisterone (Compound) and Norethisterone (Compound) resembles Mestranol (Compound)
Levofloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ethinylestradiol (Compound) and Ethinylestradiol (Compound) resembles Mestranol (Compound)
Levofloxacin (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Norethisterone (Compound) and Norethisterone (Compound) resembles Mestranol (Compound)
Levofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with ESR1 (Gene) and ESR1 (Gene) is bound by Mestranol (Compound)
Levofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is regulated by UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Mestranol (Compound)
Levofloxacin (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Ethinylestradiol (Compound) and Ethinylestradiol (Compound) resembles Mestranol (Compound)
Levofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) regulates HSD17B10 (Gene) and HSD17B10 (Gene) is downregulated by Mestranol (Compound)
Levofloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Mestranol