DDInter1938 DDInter1259
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Vincristine {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Pefloxacin
Pefloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) DHRS7
DHRS7 {u} (Gene) is downregulated by {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Nalidixic acid
Vincristine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Nalidixic acid (Compound)
Vincristine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Vincristine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Vincristine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Nalidixic acid (Compound)
Vincristine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Norfloxacin (Compound) and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Vincristine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Nalidixic acid (Compound)
Vincristine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Pefloxacin (Compound) and Pefloxacin (Compound) resembles Nalidixic acid (Compound)
Vincristine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is regulated by DHRS7 (Gene) and DHRS7 (Gene) is downregulated by Nalidixic acid (Compound)
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Nalidixic acid (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Norfloxacin and Norfloxacin (Compound) resembles Nalidixic acid (Compound)