DDInter1642 DDInter1044
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this, levamisole was used as an antirheumatic therapy in the 1970s and 1980s for patients with rheumatoid arthritis. Because of its immunomodulatory effects, this drug has been studied in the treatment of various immune-mediated diseases, with some studies showing positive results. This drug has also been used in combination with other drugs for the treatment of various cancers. [A178117, A178123] Levamisole was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis. Interestingly, levamisole has been found as an adulterant in cocaine and can lead to a variety of adverse effects in individuals using this drug.
Levamisole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alemtuzumab
Levamisole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ustekinumab
Levamisole {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Levamisole {u} may lead to a major life threatening interaction when taken with {v} Infliximab
Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab
Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Levamisole may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Levamisole may lead to a major life threatening interaction when taken with Infliximab