DDInter812 DDInter1840
Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA approval on 21 December 1981.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Gemfibrozil {u} (Compound) upregulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) binds {v} (Gene) PPARA
PPARA {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) upregulates {v} (Gene) EZH2
EZH2 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) downregulates {v} (Gene) LAP3
LAP3 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} (Compound) upregulates {v} (Gene) SQRDL
SQRDL {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Montelukast
Montelukast {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil {u} may lead to a major life threatening interaction when taken with {v} Pioglitazone
Pioglitazone {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Gemfibrozil (Compound) upregulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Gemfibrozil (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Trabectedin (Compound)
Gemfibrozil (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Trabectedin (Compound)
Gemfibrozil (Compound) binds PPARA (Gene) and PPARA (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Gemfibrozil (Compound) upregulates EZH2 (Gene) and EZH2 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Gemfibrozil (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Gemfibrozil (Compound) downregulates LAP3 (Gene) and LAP3 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Gemfibrozil (Compound) upregulates SQRDL (Gene) and SQRDL (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Gemfibrozil may cause a moderate interaction that could exacerbate diseases when taken with Montelukast and Montelukast (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Gemfibrozil may lead to a major life threatening interaction when taken with Pioglitazone and Pioglitazone (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)