DDInter1572 DDInter1376
Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Rasagiline {u} (Compound) binds {v} (Gene) CYP1A2
Rasagiline {u} (Compound) palliates {v} (Disease) Parkinson's disease
Rasagiline {u} (Compound) causes {v} (Side Effect) Asthenia
Rasagiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetohexamide
Rasagiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenindamine
Rasagiline {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Rasagiline {u} may lead to a major life threatening interaction when taken with {v} Rucaparib
Rasagiline (Compound) binds CYP1A2 (Gene)
Rasagiline (Compound) palliates Parkinson's disease (Disease)
Rasagiline (Compound) causes Asthenia (Side Effect)
Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine
Rasagiline may lead to a major life threatening interaction when taken with Dexfenfluramine
Rasagiline may lead to a major life threatening interaction when taken with Rucaparib