DDInter856 DDInter334
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.
Ceftriaxone {u} (Compound) resembles {v} (Compound) Cefacetrile
Ceftriaxone {u} (Compound) resembles {v} (Compound) Cefpodoxime
Ceftriaxone {u} (Compound) binds {v} (Gene) SLC15A1
Ceftriaxone {u} (Compound) is included by {v} (Pharmacologic Class) Cephalosporins
Ceftriaxone {u} (Compound) causes {v} (Side Effect) Chills
Ceftriaxone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Ceftriaxone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Ceftriaxone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Ceftriaxone {u} may lead to a major life threatening interaction when taken with {v} Calcium chloride
Ceftriaxone {u} may lead to a major life threatening interaction when taken with {v} Calcium gluconate
Ceftriaxone (Compound) resembles Cefacetrile (Compound)
Ceftriaxone (Compound) resembles Cefpodoxime (Compound)
Ceftriaxone (Compound) binds SLC15A1 (Gene)
Ceftriaxone (Compound) is included by Cephalosporins (Pharmacologic Class)
Ceftriaxone (Compound) causes Chills (Side Effect)
Ceftriaxone may cause a minor interaction that can limit clinical effects when taken with Diclofenac
Ceftriaxone may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Ceftriaxone may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Ceftriaxone may lead to a major life threatening interaction when taken with Calcium chloride
Ceftriaxone may lead to a major life threatening interaction when taken with Calcium gluconate