DDInter712 DDInter1610
Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</sub> receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory disease, famotidine was about 20 to 50 times more potent at inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a weight basis. Famotidine is used in various over-the-counter and off-label uses. While oral formulations of famotidine are more commonly used, the intravenous solution of the drug is available for use in hospital settings.
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Famotidine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Rivastigmine
Famotidine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Tapentadol
Tapentadol {u} (Compound) resembles {v} (Compound) Rivastigmine
Famotidine {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Pyridostigmine
Pyridostigmine {u} (Compound) resembles {v} (Compound) Rivastigmine
Famotidine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Tapentadol
Tapentadol {u} (Compound) resembles {v} (Compound) Rivastigmine
Famotidine {u} (Compound) upregulates {v} (Gene) E2F2
E2F2 {u} (Gene) is regulated by {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Famotidine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) CCNH
CCNH {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Famotidine {u} (Compound) upregulates {v} (Gene) E2F2
E2F2 {u} (Gene) is regulated by {v} (Gene) FGFR2
FGFR2 {u} (Gene) is upregulated by {v} (Compound) Rivastigmine
Famotidine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Rivastigmine
Famotidine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) GDPD5
GDPD5 {u} (Gene) is upregulated by {v} (Compound) Rivastigmine
Famotidine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Famotidine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivastigmine (Compound)
Famotidine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Tapentadol (Compound) and Tapentadol (Compound) resembles Rivastigmine (Compound)
Famotidine (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Pyridostigmine (Compound) and Pyridostigmine (Compound) resembles Rivastigmine (Compound)
Famotidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tapentadol (Compound) and Tapentadol (Compound) resembles Rivastigmine (Compound)
Famotidine (Compound) upregulates E2F2 (Gene) and E2F2 (Gene) is regulated by ITGB1BP1 (Gene) and ITGB1BP1 (Gene) is downregulated by Rivastigmine (Compound)
Famotidine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by CCNH (Gene) and CCNH (Gene) is downregulated by Rivastigmine (Compound)
Famotidine (Compound) upregulates E2F2 (Gene) and E2F2 (Gene) is regulated by FGFR2 (Gene) and FGFR2 (Gene) is upregulated by Rivastigmine (Compound)
Famotidine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Rivastigmine (Compound)
Famotidine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by GDPD5 (Gene) and GDPD5 (Gene) is upregulated by Rivastigmine (Compound)
Famotidine (Compound) downregulates DLD (Gene) and DLD (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Rivastigmine (Compound)