DDInter1055 DDInter1756
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Levofloxacin {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Vancomycin
Vancomycin {u} (Compound) resembles {v} (Compound) Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Oritavancin
Oritavancin {u} (Compound) resembles {v} (Compound) Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Hyperkalaemia
Hyperkalaemia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Fluid overload
Fluid overload {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Dolasetron {u} may lead to a major life threatening interaction when taken with {v} Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Gastrointestinal haemorrhage
Gastrointestinal haemorrhage {u} (Side Effect) is caused by {v} (Compound) Bosutinib
Bosutinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telavancin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Vemurafenib
Vemurafenib {u} may lead to a major life threatening interaction when taken with {v} Telavancin
Levofloxacin {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Vancomycin
Vancomycin {u} (Compound) resembles {v} (Compound) Telavancin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Telavancin
Levofloxacin (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Telavancin (Compound)
Levofloxacin (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
Levofloxacin (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Vancomycin (Compound) and Vancomycin (Compound) resembles Telavancin (Compound)
Levofloxacin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Oritavancin (Compound) and Oritavancin (Compound) resembles Telavancin (Compound)
Levofloxacin (Compound) causes Hyperkalaemia (Side Effect) and Hyperkalaemia (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Telavancin
Levofloxacin (Compound) causes Fluid overload (Side Effect) and Fluid overload (Side Effect) is caused by Dolasetron (Compound) and Dolasetron may lead to a major life threatening interaction when taken with Telavancin
Levofloxacin (Compound) causes Gastrointestinal haemorrhage (Side Effect) and Gastrointestinal haemorrhage (Side Effect) is caused by Bosutinib (Compound) and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Telavancin
Levofloxacin (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Vemurafenib (Compound) and Vemurafenib may lead to a major life threatening interaction when taken with Telavancin
Levofloxacin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Vancomycin (Compound) and Vancomycin (Compound) resembles Telavancin (Compound)
Levofloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Telavancin (Compound)