DDInter624 DDInter1533
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Efavirenz {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Promethazine
Efavirenz {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Promethazine
Efavirenz {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Efavirenz {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Benzphetamine
Benzphetamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Efavirenz {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Efavirenz {u} (Compound) causes {v} (Side Effect) Coordination abnormal
Coordination abnormal {u} (Side Effect) is caused by {v} (Compound) Desipramine
Desipramine {u} (Compound) resembles {v} (Compound) Promethazine
Efavirenz {u} (Compound) causes {v} (Side Effect) Euphoric mood
Euphoric mood {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) is treated by {v} (Compound) Saquinavir
Saquinavir {u} may lead to a major life threatening interaction when taken with {v} Promethazine
Efavirenz {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Promethazine
Efavirenz {u} (Compound) causes {v} (Side Effect) Asthma
Asthma {u} (Side Effect) is caused by {v} (Compound) Propericiazine
Propericiazine {u} (Compound) resembles {v} (Compound) Promethazine
Efavirenz (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Promethazine (Compound)
Efavirenz (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Promethazine (Compound)
Efavirenz (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Efavirenz (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Benzphetamine (Compound) and Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Efavirenz (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Efavirenz (Compound) causes Coordination abnormal (Side Effect) and Coordination abnormal (Side Effect) is caused by Desipramine (Compound) and Desipramine (Compound) resembles Promethazine (Compound)
Efavirenz (Compound) causes Euphoric mood (Side Effect) and Euphoric mood (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) is treated by Saquinavir (Compound) and Saquinavir may lead to a major life threatening interaction when taken with Promethazine
Efavirenz (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Diltiazem (Compound) and Diltiazem (Compound) resembles Promethazine (Compound)
Efavirenz (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Propericiazine (Compound) and Propericiazine (Compound) resembles Promethazine (Compound)