DDInter1285 DDInter998
A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the treatment of onchocerciasis, but may also be effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis). Applied topically, it may be used in the treatment of head lice infestation. With the advent of 2020 and the COVID-19 pandemic, ivermectin began garnering notoriety due to its off-label use for the prophylaxis and treatment of COVID-19. While studies are still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and the clinical utility of this data remains unclear. Due to a number of factors - for example, the relatively low number of patients per trial and the speed at which these trials were conducted - studies on the use of ivermectin in COVID-19 have been fraught with statistical errors and accusations of plagiarism.[L36763,A238929] In addition, the use of aggregate patient data in large-scale meta-analyses (as opposed to individual patient data (IPD)) has been shown to disguise otherwise blatant data errors, such as extreme terminal digit bias and the duplication of blocks of patient records. Until high-quality, peer-reviewed data regarding both the safety and efficacy of ivermectin for COVID-19 in humans becomes available, the use of ivermectin for these purposes should be avoided in favour of thoroughly-vetted therapies (e.g. COVID-19 vaccines like [Comirnaty](https://go.drugbank.com/drugs/DB15696)).
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ivermectin
Nevirapine {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Ivermectin
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Nevirapine {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Nevirapine {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) upregulates {v} (Gene) WARS
WARS {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nevirapine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prasugrel
Prasugrel {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ivermectin
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nevirapine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Bortezomib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ivermectin
Nevirapine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prasugrel
Prasugrel {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Ivermectin
Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivermectin (Compound)
Nevirapine (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Ivermectin (Compound)
Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with PGRMC1 (Gene) and PGRMC1 (Gene) is downregulated by Ivermectin (Compound)
Nevirapine (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates MYC (Gene) and MYC (Gene) is upregulated by Ivermectin (Compound)
Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Ivermectin (Compound)
Nevirapine (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) upregulates WARS (Gene) and WARS (Gene) is upregulated by Ivermectin (Compound)
Nevirapine may cause a minor interaction that can limit clinical effects when taken with Prasugrel and Prasugrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivermectin (Compound)
Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Ivermectin (Compound)
Nevirapine may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivermectin (Compound)
Nevirapine may cause a minor interaction that can limit clinical effects when taken with Prasugrel and Prasugrel (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ivermectin (Compound)