DDInter1042 DDInter1420
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Pentamidine {u} (Compound) resembles {v} (Compound) Ospemifene
Pentamidine {u} (Compound) binds {v} (Gene) S100B
Pentamidine {u} (Compound) upregulates {v} (Gene) CDK7
Pentamidine {u} (Compound) downregulates {v} (Gene) TYMS
Pentamidine {u} (Compound) causes {v} (Side Effect) Azotaemia
Pentamidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gilteritinib
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Macimorelin
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Pentamidine (Compound) resembles Ospemifene (Compound)
Pentamidine (Compound) binds S100B (Gene)
Pentamidine (Compound) upregulates CDK7 (Gene)
Pentamidine (Compound) downregulates TYMS (Gene)
Pentamidine (Compound) causes Azotaemia (Side Effect)
Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Galantamine
Pentamidine may lead to a major life threatening interaction when taken with Macimorelin
Pentamidine may lead to a major life threatening interaction when taken with Bexarotene