DDInter842 DDInter255
Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Fludarabine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Sibutramine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Fludarabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Sibutramine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Fludarabine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomustine
Lomustine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cytarabine
Cytarabine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cytarabine
Cytarabine {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cytarabine
Cytarabine {u} (Compound) binds {v} (Gene) POLB
POLB {u} (Gene) is upregulated by {v} (Compound) Busulfan
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clofarabine
Clofarabine {u} (Compound) upregulates {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine and Fludarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine and Fludarabine (Compound) binds DCK (Gene) and DCK (Gene) is downregulated by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine and Fludarabine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Lomustine and Lomustine (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Cytarabine and Cytarabine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Cytarabine and Cytarabine (Compound) upregulates C5 (Gene) and C5 (Gene) is upregulated by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Cytarabine and Cytarabine (Compound) binds POLB (Gene) and POLB (Gene) is upregulated by Busulfan (Compound)
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Clofarabine and Clofarabine (Compound) upregulates DNAJB2 (Gene) and DNAJB2 (Gene) is downregulated by Busulfan (Compound)