DDInter1425 DDInter178
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Pentostatin {u} (Compound) resembles {v} (Compound) Trifluridine
Pentostatin {u} (Compound) resembles {v} (Compound) Azacitidine
Pentostatin {u} (Compound) treats {v} (Disease) hematologic cancer
Pentostatin {u} (Compound) binds {v} (Gene) ADA
Pentostatin {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Pentostatin {u} (Compound) causes {v} (Side Effect) Foetor hepaticus
Pentostatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enoxacin
Pentostatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Pentostatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Pentostatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxyurea
Pentostatin (Compound) resembles Trifluridine (Compound)
Pentostatin (Compound) resembles Azacitidine (Compound)
Pentostatin (Compound) treats hematologic cancer (Disease)
Pentostatin (Compound) binds ADA (Gene)
Pentostatin (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Pentostatin (Compound) causes Foetor hepaticus (Side Effect)
Pentostatin may cause a minor interaction that can limit clinical effects when taken with Enoxacin
Pentostatin may cause a minor interaction that can limit clinical effects when taken with Ofloxacin
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea