DDInter757 DDInter1376
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Fluorouracil {u} (Compound) resembles {v} (Compound) Uracil mustard
Fluorouracil {u} (Compound) treats {v} (Disease) head and neck cancer
Fluorouracil {u} (Compound) binds {v} (Gene) CYP2C8
Fluorouracil {u} (Compound) upregulates {v} (Gene) SERPINA3
Fluorouracil {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Fluorouracil {u} (Compound) downregulates {v} (Gene) PTPRO
Fluorouracil {u} (Compound) causes {v} (Side Effect) Ventricular septal defect
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Fluorouracil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Temozolomide
Fluorouracil (Compound) resembles Uracil mustard (Compound)
Fluorouracil (Compound) treats head and neck cancer (Disease)
Fluorouracil (Compound) binds CYP2C8 (Gene)
Fluorouracil (Compound) upregulates SERPINA3 (Gene)
Fluorouracil (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Fluorouracil (Compound) downregulates PTPRO (Gene)
Fluorouracil (Compound) causes Ventricular septal defect (Side Effect)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide