DDInter1042 DDInter1534
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Propafenone {u} (Compound) resembles {v} (Compound) Atomoxetine
Propafenone {u} (Compound) resembles {v} (Compound) Benazepril
Propafenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salmeterol
Propafenone {u} (Compound) binds {v} (Gene) CYP2C9
Propafenone {u} (Compound) upregulates {v} (Gene) KIAA0355
Propafenone {u} (Compound) downregulates {v} (Gene) IFRD2
Propafenone {u} (Compound) causes {v} (Side Effect) Lupus-like syndrome
Propafenone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Propafenone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Propafenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olodaterol
Propafenone (Compound) resembles Atomoxetine (Compound)
Propafenone (Compound) resembles Benazepril (Compound)
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Propafenone (Compound) binds CYP2C9 (Gene)
Propafenone (Compound) upregulates KIAA0355 (Gene)
Propafenone (Compound) downregulates IFRD2 (Gene)
Propafenone (Compound) causes Lupus-like syndrome (Side Effect)
Propafenone may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Propafenone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol