DDInter1055 DDInter1683
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Levofloxacin {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium bicarbonate
Levofloxacin {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium bicarbonate
Levofloxacin {u} (Compound) causes {v} (Side Effect) Clotting
Clotting {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium bicarbonate
Levofloxacin {u} (Compound) causes {v} (Side Effect) Hypernatraemia
Hypernatraemia {u} (Side Effect) is caused by {v} (Compound) Acetic acid
Acetic acid {u} (Compound) resembles {v} (Compound) Sodium bicarbonate
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Levofloxacin {u} (Compound) causes {v} (Side Effect) Swelling face
Swelling face {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium bicarbonate
Levofloxacin {u} (Compound) causes {v} (Side Effect) Creatinine increased
Creatinine increased {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Ponatinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium bicarbonate
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) covaries with {v} (Gene) SLC4A8
SLC4A8 {u} (Gene) is bound by {v} (Compound) Sodium bicarbonate
Levofloxacin {u} (Compound) downregulates {v} (Gene) PRKACA
PRKACA {u} (Gene) interacts with {v} (Gene) SLC4A4
SLC4A4 {u} (Gene) is bound by {v} (Compound) Sodium bicarbonate
Levofloxacin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Levofloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Sodium bicarbonate
Levofloxacin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Levofloxacin (Compound) causes Clotting (Side Effect) and Clotting (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Sodium bicarbonate
Levofloxacin (Compound) causes Hypernatraemia (Side Effect) and Hypernatraemia (Side Effect) is caused by Acetic acid (Compound) and Acetic acid (Compound) resembles Sodium bicarbonate (Compound)
Levofloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Levofloxacin (Compound) causes Swelling face (Side Effect) and Swelling face (Side Effect) is caused by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sodium bicarbonate
Levofloxacin (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Ponatinib (Compound) and Ponatinib may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) covaries with SLC4A8 (Gene) and SLC4A8 (Gene) is bound by Sodium bicarbonate (Compound)
Levofloxacin (Compound) downregulates PRKACA (Gene) and PRKACA (Gene) interacts with SLC4A4 (Gene) and SLC4A4 (Gene) is bound by Sodium bicarbonate (Compound)