DDInter1939 DDInter1938
Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting. A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug.
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Vinorelbine {u} (Compound) resembles {v} (Compound) Voacamine
Voacamine {u} (Compound) resembles {v} (Compound) Vincristine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Vinorelbine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Vinorelbine {u} (Compound) binds {v} (Gene) TUBB
TUBB {u} (Gene) is bound by {v} (Compound) Vincristine
Vinorelbine {u} (Compound) upregulates {v} (Gene) TICAM1
TICAM1 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Vinorelbine {u} (Compound) is included by {v} (Pharmacologic Class) Vinca Alkaloids
Vinca Alkaloids {u} (Pharmacologic Class) includes {v} (Compound) Vincristine
Vinorelbine {u} (Compound) downregulates {v} (Gene) HACD3
HACD3 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Vinorelbine {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Vincristine
Vinorelbine {u} (Compound) binds {v} (Gene) TUBB2A
TUBB2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Vincristine
Vinorelbine (Compound) resembles Vincristine (Compound)
Vinorelbine (Compound) resembles Voacamine (Compound) and Voacamine (Compound) resembles Vincristine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine (Compound) resembles Vincristine (Compound)
Vinorelbine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vincristine (Compound)
Vinorelbine (Compound) binds TUBB (Gene) and TUBB (Gene) is bound by Vincristine (Compound)
Vinorelbine (Compound) upregulates TICAM1 (Gene) and TICAM1 (Gene) is upregulated by Vincristine (Compound)
Vinorelbine (Compound) is included by Vinca Alkaloids (Pharmacologic Class) and Vinca Alkaloids (Pharmacologic Class) includes Vincristine (Compound)
Vinorelbine (Compound) downregulates HACD3 (Gene) and HACD3 (Gene) is downregulated by Vincristine (Compound)
Vinorelbine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Vincristine (Compound)
Vinorelbine (Compound) binds TUBB2A (Gene) and TUBB2A (Gene) is bound by Vincristine (Compound) and TUBB2A (Gene) is upregulated by Vincristine (Compound)