DDInter1716 DDInter1123
Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.
Succinylcholine {u} (Compound) causes {v} (Side Effect) Pulmonary oedema
Pulmonary oedema {u} (Side Effect) is caused by {v} (Compound) Mannitol
Succinylcholine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) resembles {v} (Compound) Mannitol
Succinylcholine {u} (Compound) resembles {v} (Compound) Carbachol
Carbachol {u} (Compound) treats {v} (Disease) glaucoma
glaucoma {u} (Disease) is palliated by {v} (Compound) Mannitol
Succinylcholine {u} (Compound) resembles {v} (Compound) Carbachol
Carbachol {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Mannitol
Succinylcholine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Irinotecan
Irinotecan {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Succinylcholine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Irinotecan
Irinotecan {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Succinylcholine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Physostigmine
Physostigmine {u} (Compound) treats {v} (Disease) glaucoma
glaucoma {u} (Disease) is palliated by {v} (Compound) Mannitol
Succinylcholine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Cyclophosphamide {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Succinylcholine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Physostigmine
Physostigmine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Mannitol
Succinylcholine {u} may lead to a major life threatening interaction when taken with {v} Neomycin
Neomycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Mannitol
Succinylcholine (Compound) causes Pulmonary oedema (Side Effect) and Pulmonary oedema (Side Effect) is caused by Mannitol (Compound)
Succinylcholine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) resembles Mannitol (Compound)
Succinylcholine (Compound) resembles Carbachol (Compound) and Carbachol (Compound) treats glaucoma (Disease) and glaucoma (Disease) is palliated by Mannitol (Compound)
Succinylcholine (Compound) resembles Carbachol (Compound) and Carbachol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Mannitol (Compound)
Succinylcholine may cause a minor interaction that can limit clinical effects when taken with Irinotecan and Irinotecan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Succinylcholine may cause a minor interaction that can limit clinical effects when taken with Irinotecan and Irinotecan (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and Physostigmine (Compound) treats glaucoma (Disease) and glaucoma (Disease) is palliated by Mannitol (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide and Cyclophosphamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and Physostigmine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Mannitol (Compound)
Succinylcholine may lead to a major life threatening interaction when taken with Neomycin and Neomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Mannitol (Compound)