DDInter252 DDInter981
Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. More specifically, bupropion binds to the norepinephrine transporter (NET) and the dopamine transporter (DAT).[A6399,A178810] Bupropion was originally classified as an "atypical" antidepressant because it does not exert the same effects as the classical antidepressants such as Monoamine Oxidase Inhibitors (MA
Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Isocarboxazid
Bupropion {u} (Compound) causes {v} (Side Effect) Amblyopia
Amblyopia {u} (Side Effect) is caused by {v} (Compound) Isocarboxazid
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is associated with {v} (Gene) MAOA
MAOA {u} (Gene) is bound by {v} (Compound) Isocarboxazid
Bupropion {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Lacosamide
Lacosamide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion {u} (Compound) causes {v} (Side Effect) Erectile dysfunction
Erectile dysfunction {u} (Side Effect) is caused by {v} (Compound) Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Amphetamine
Amphetamine {u} (Compound) resembles {v} (Compound) Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Isocarboxazid
Bupropion may lead to a major life threatening interaction when taken with Metamfetamine and Metamfetamine (Compound) resembles Isocarboxazid (Compound)
Bupropion (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Isocarboxazid (Compound)
Bupropion (Compound) causes Amblyopia (Side Effect) and Amblyopia (Side Effect) is caused by Isocarboxazid (Compound)
Bupropion may lead to a major life threatening interaction when taken with Metamfetamine and Metamfetamine (Compound) resembles Phenacemide (Compound) and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Bupropion (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is associated with MAOA (Gene) and MAOA (Gene) is bound by Isocarboxazid (Compound)
Bupropion (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Lacosamide (Compound) and Lacosamide (Compound) resembles Isocarboxazid (Compound)
Bupropion (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Metamfetamine (Compound) and Metamfetamine (Compound) resembles Isocarboxazid (Compound)
Bupropion may lead to a major life threatening interaction when taken with Phentermine and Phentermine (Compound) resembles Phenacemide (Compound) and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Bupropion may lead to a major life threatening interaction when taken with Amphetamine and Amphetamine (Compound) resembles Phenacemide (Compound) and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Bupropion may lead to a major life threatening interaction when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Isocarboxazid (Compound)