DDInter1404 DDInter576
Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia cells have low levels of this enzyme and depend on exogenous sources. Therefore, the use of pegaspargase results in leukemic cell death.[A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic leukemia (ALL). However, using L-asparaginase derived from _Escherich
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propylthiouracil
Propylthiouracil {u} (Compound) binds {v} (Gene) DBH
DBH {u} (Gene) is bound by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propylthiouracil
Propylthiouracil {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Maraviroc {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valproic acid
Valproic acid {u} (Compound) binds {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CXCL8
CXCL8 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Methylprednisolone {u} (Compound) upregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Pegaspargase {u} may lead to a major life threatening interaction when taken with {v} Lomitapide
Lomitapide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil and Propylthiouracil (Compound) binds DBH (Gene) and DBH (Gene) is bound by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil and Propylthiouracil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc and Maraviroc (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac (Compound) binds CXCL8 (Gene) and CXCL8 (Gene) is upregulated by Disulfiram (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) upregulates JADE2 (Gene) and JADE2 (Gene) is downregulated by Disulfiram (Compound)
Pegaspargase may lead to a major life threatening interaction when taken with Lomitapide and Lomitapide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)