DDInter1888 DDInter717
An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.
Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712, A214715] Fenfluramine is a serotonergic phenethylamine originally used as an appetite suppressant until concerns regarding cardiotoxicity in obese patients lead to its withdrawal from the market in 1997.[A214694, A214718, A11906] Through its ability to modulate neurotransmission, fenfluramine has reemerged as an effective therapy against pharmacoresistant seizures, such as those involved in Dravet syndrome.[A214688, A214691, A214700] Fenfluramine was granted initial FDA approval in 1973 prior to its withdrawal; it was granted a new FDA approval on June 25, 2020, for treatment of patients with Dravet syndrome and Lennox-Gastaut syndrome through the restricted FINTEPLA REMS program. It is currently sold under the name FINTEPLA® by Zogenix INC.
Tryptophan {u} (Compound) resembles {v} (Compound) Oxitriptan
Oxitriptan {u} may lead to a major life threatening interaction when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) L-Phenylalanine
L-Phenylalanine {u} (Compound) resembles {v} (Compound) Oxitriptan
Oxitriptan {u} may lead to a major life threatening interaction when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) Oxitriptan
Oxitriptan {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) L-Histidine
L-Histidine {u} (Compound) resembles {v} (Compound) Oxitriptan
Oxitriptan {u} may lead to a major life threatening interaction when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) L-Phenylalanine
L-Phenylalanine {u} (Compound) resembles {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) Oxitriptan
Oxitriptan {u} (Compound) resembles {v} (Compound) Liothyronine
Liothyronine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) Oxitriptan
Oxitriptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) L-Tyrosine
L-Tyrosine {u} (Compound) resembles {v} (Compound) Liothyronine
Liothyronine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan {u} (Compound) resembles {v} (Compound) Levodopa
Levodopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan {u} (Compound) binds {v} (Gene) SLC16A2
SLC16A2 {u} (Gene) is bound by {v} (Compound) Levothyroxine
Levothyroxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Tryptophan (Compound) resembles Oxitriptan (Compound) and Oxitriptan may lead to a major life threatening interaction when taken with Fenfluramine
Tryptophan (Compound) resembles L-Phenylalanine (Compound) and L-Phenylalanine (Compound) resembles Oxitriptan (Compound) and Oxitriptan may lead to a major life threatening interaction when taken with Fenfluramine
Tryptophan (Compound) resembles Oxitriptan (Compound) and Oxitriptan may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tryptophan (Compound) resembles L-Histidine (Compound) and L-Histidine (Compound) resembles Oxitriptan (Compound) and Oxitriptan may lead to a major life threatening interaction when taken with Fenfluramine
Tryptophan (Compound) resembles L-Phenylalanine (Compound) and L-Phenylalanine (Compound) resembles Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tryptophan (Compound) resembles Oxitriptan (Compound) and Oxitriptan (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tryptophan (Compound) resembles Oxitriptan (Compound) and Oxitriptan may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tryptophan (Compound) resembles L-Tyrosine (Compound) and L-Tyrosine (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tryptophan (Compound) resembles Levodopa (Compound) and Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tryptophan (Compound) binds SLC16A2 (Gene) and SLC16A2 (Gene) is bound by Levothyroxine (Compound) and Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine