DDInter298 DDInter1144
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem cell transplant. It is also used to treat uveal melanoma with unresectable hepatic metastases.
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Melphalan
Carboplatin {u} (Compound) causes {v} (Side Effect) Extravasation
Extravasation {u} (Side Effect) is caused by {v} (Compound) Melphalan
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Carboplatin {u} (Compound) causes {v} (Side Effect) Extravasation
Extravasation {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Melphalan
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Levodopa
Levodopa {u} (Compound) resembles {v} (Compound) Melphalan
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) resembles {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Melphalan
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) resembles {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Melphalan
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Melphalan
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Melphalan (Compound)
Carboplatin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Melphalan (Compound)
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Carboplatin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Melphalan
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Ibuprofen (Compound) and Ibuprofen (Compound) resembles Melphalan (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Melphalan
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Levodopa (Compound) and Levodopa (Compound) resembles Melphalan (Compound)
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) resembles breast cancer (Disease) and breast cancer (Disease) is treated by Melphalan (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) resembles ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Melphalan (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Melphalan (Compound)