DDInter364 DDInter790
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, deb
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.
Chlorpropamide {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Bumetanide
Bumetanide {u} (Compound) resembles {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Gliclazide
Gliclazide {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Probenecid
Probenecid {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Gliclazide
Gliclazide {u} (Compound) causes {v} (Side Effect) Epigastric discomfort
Epigastric discomfort {u} (Side Effect) is caused by {v} (Compound) Furosemide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glimepiride
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Chlorpropamide (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Furosemide (Compound)
Chlorpropamide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Furosemide (Compound)
Chlorpropamide (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Bumetanide (Compound) and Bumetanide (Compound) resembles Furosemide (Compound)
Chlorpropamide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Furosemide (Compound)
Chlorpropamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Furosemide (Compound)
Chlorpropamide (Compound) resembles Gliclazide (Compound) and Gliclazide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Furosemide (Compound)
Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Furosemide (Compound)
Chlorpropamide (Compound) resembles Probenecid (Compound) and Probenecid (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Furosemide (Compound)
Chlorpropamide (Compound) resembles Gliclazide (Compound) and Gliclazide (Compound) causes Epigastric discomfort (Side Effect) and Epigastric discomfort (Side Effect) is caused by Furosemide (Compound)
Chlorpropamide (Compound) resembles Glimepiride (Compound) and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Furosemide (Compound)