DDInter1938 DDInter1442
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Vincristine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Vincristine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Vincristine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Vincristine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Vincristine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Vincristine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Vincristine {u} (Compound) causes {v} (Side Effect) Respiratory failure
Respiratory failure {u} (Side Effect) is caused by {v} (Compound) Secobarbital
Secobarbital {u} (Compound) resembles {v} (Compound) Phenobarbital
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Vincristine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Phenobarbital (Compound)
Vincristine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Phenobarbital (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Vincristine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Vincristine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Vincristine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Phenytoin (Compound) and Phenytoin (Compound) resembles Phenobarbital (Compound)
Vincristine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Phenobarbital (Compound)
Vincristine (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Secobarbital (Compound) and Secobarbital (Compound) resembles Phenobarbital (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)