DDInter1018 DDInter1662
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and its first clinical use for treating PSE was not until 1966. Nevertheless, although lactulose received formal FDA approval in 1977 and has since become a readily available generic and brand-name non-prescription medication listed on the World Health Organization's List of Essential Medicines as one of the most effective and safe medicines employed in a health system, data regarding its optimal place in therapy is often ambiguous. Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Lactulose {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Sertraline
Lactulose {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Lactulose {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sertraline
Lactulose {u} (Compound) resembles {v} (Compound) Paromomycin
Paromomycin {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Lactulose {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Sertraline
Lactulose {u} (Compound) resembles {v} (Compound) Acarbose
Acarbose {u} (Compound) causes {v} (Side Effect) Immune system disorder
Immune system disorder {u} (Side Effect) is caused by {v} (Compound) Sertraline
Lactulose {u} (Compound) resembles {v} (Compound) Glucosamine
Glucosamine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Sertraline
Lactulose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Neomycin
Neomycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Sertraline
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perflutren
Perflutren {u} (Compound) causes {v} (Side Effect) Haemoglobin
Haemoglobin {u} (Side Effect) is caused by {v} (Compound) Sertraline
Lactulose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Sorafenib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sertraline
Lactulose (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Sertraline (Compound)
Lactulose (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Lactulose (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sertraline (Compound)
Lactulose (Compound) resembles Paromomycin (Compound) and Paromomycin (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Sertraline (Compound)
Lactulose (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Sertraline (Compound)
Lactulose (Compound) resembles Acarbose (Compound) and Acarbose (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Sertraline (Compound)
Lactulose (Compound) resembles Glucosamine (Compound) and Glucosamine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Sertraline (Compound)
Lactulose may cause a minor interaction that can limit clinical effects when taken with Neomycin and Neomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Sertraline (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Sertraline (Compound)
Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sertraline (Compound)