DDInter1853 DDInter129
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications. The U.S. Food and Drug Administration (FDA) approved atazanavir on June 20, 2003.
Tretinoin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Hepatocellular injury
Hepatocellular injury {u} (Side Effect) is caused by {v} (Compound) Atazanavir
Tretinoin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Hepatocellular injury
Hepatocellular injury {u} (Side Effect) is caused by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Nasal congestion
Nasal congestion {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Terbinafine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Cardiac arrest
Cardiac arrest {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Wheezing
Wheezing {u} (Side Effect) is caused by {v} (Compound) Ciclesonide
Ciclesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Nasopharyngitis
Nasopharyngitis {u} (Side Effect) is caused by {v} (Compound) Abiraterone
Abiraterone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atazanavir
Tretinoin {u} (Compound) causes {v} (Side Effect) Myocarditis
Myocarditis {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Atazanavir
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Caffeine
Caffeine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atazanavir
Tretinoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atazanavir (Compound)
Tretinoin (Compound) causes Hepatocellular injury (Side Effect) and Hepatocellular injury (Side Effect) is caused by Atazanavir (Compound)
Tretinoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ritonavir (Compound) and Ritonavir (Compound) resembles Atazanavir (Compound)
Tretinoin (Compound) causes Hepatocellular injury (Side Effect) and Hepatocellular injury (Side Effect) is caused by Ritonavir (Compound) and Ritonavir (Compound) resembles Atazanavir (Compound)
Tretinoin (Compound) causes Nasal congestion (Side Effect) and Nasal congestion (Side Effect) is caused by Terbinafine (Compound) and Terbinafine may cause a minor interaction that can limit clinical effects when taken with Atazanavir
Tretinoin (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir
Tretinoin (Compound) causes Wheezing (Side Effect) and Wheezing (Side Effect) is caused by Ciclesonide (Compound) and Ciclesonide may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir
Tretinoin (Compound) causes Nasopharyngitis (Side Effect) and Nasopharyngitis (Side Effect) is caused by Abiraterone (Compound) and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Atazanavir
Tretinoin (Compound) causes Myocarditis (Side Effect) and Myocarditis (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Atazanavir
Tretinoin (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Caffeine (Compound) and Caffeine may cause a minor interaction that can limit clinical effects when taken with Atazanavir