DDInter1397 DDInter245
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Paroxetine {u} (Compound) binds {v} (Gene) CHRM4
CHRM4 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Paroxetine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Brompheniramine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM4
CHRM4 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Ketamine
Ketamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Paroxetine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Dexbrompheniramine
Dexbrompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM2
CHRM2 {u} (Gene) is bound by {v} (Compound) Dimetindene
Dimetindene {u} (Compound) resembles {v} (Compound) Brompheniramine
Paroxetine {u} (Compound) upregulates {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Paroxetine {u} (Compound) upregulates {v} (Gene) EBP
EBP {u} (Gene) is bound by {v} (Compound) Haloperidol
Haloperidol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Paroxetine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Paroxetine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) regulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Brompheniramine
Paroxetine (Compound) binds CHRM4 (Gene) and CHRM4 (Gene) is bound by Brompheniramine (Compound)
Paroxetine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Brompheniramine (Compound)
Paroxetine (Compound) binds CHRM4 (Gene) and CHRM4 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Paroxetine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ketamine (Compound) and Ketamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Paroxetine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Dexbrompheniramine (Compound) and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Paroxetine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Dimetindene (Compound) and Dimetindene (Compound) resembles Brompheniramine (Compound)
Paroxetine (Compound) upregulates EBP (Gene) and EBP (Gene) is upregulated by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Paroxetine (Compound) upregulates EBP (Gene) and EBP (Gene) is bound by Haloperidol (Compound) and Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Paroxetine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Paroxetine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) regulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Brompheniramine (Compound)