DDInter1793 DDInter1397
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Thiethylperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Sucralfate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Nicardipine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pregabalin
Pregabalin {u} (Compound) causes {v} (Side Effect) Candida infection
Candida infection {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Trospium {u} (Compound) binds {v} (Gene) CHRM3
CHRM3 {u} (Gene) is bound by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenelzine
Phenelzine {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenelzine
Phenelzine {u} (Compound) downregulates {v} (Gene) CSRP1
CSRP1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Escitalopram
Escitalopram {u} (Compound) palliates {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimipramine
Trimipramine {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Escitalopram
Escitalopram {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pregabalin and Pregabalin (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) palliates endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Paroxetine (Compound)