DDInter600 DDInter504
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Promazine {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} (Compound) resembles {v} (Compound) Dimetacrine
Dimetacrine {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} (Compound) resembles {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Desipramine
Doxylamine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Desipramine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Promazine {u} (Compound) resembles {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine {u} (Compound) resembles {v} (Compound) Dimetacrine
Dimetacrine {u} (Compound) resembles {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Desipramine
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Desipramine (Compound)
Doxylamine (Compound) resembles Dimetacrine (Compound) and Dimetacrine (Compound) resembles Desipramine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Desipramine (Compound)
Doxylamine (Compound) resembles Amitriptyline (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Desipramine (Compound)
Doxylamine (Compound) resembles Imipramine (Compound) and Imipramine (Compound) resembles Desipramine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Desipramine (Compound)
Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Desipramine (Compound)
Doxylamine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Desipramine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Triflupromazine (Compound) and Triflupromazine (Compound) resembles Desipramine (Compound)
Doxylamine (Compound) resembles Dimetacrine (Compound) and Dimetacrine (Compound) resembles Promazine (Compound) and Promazine (Compound) resembles Desipramine (Compound)