DDInter576 DDInter1682
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
Disulfiram {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) is downregulated by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) is downregulated by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) upregulates {v} (Gene) EGR1
EGR1 {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) upregulates {v} (Gene) FOSL1
FOSL1 {u} (Gene) is downregulated by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may lead to a major life threatening interaction when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) downregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may lead to a major life threatening interaction when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium aurothiomalate
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium aurothiomalate
Disulfiram (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Disulfiram (Compound) downregulates COG4 (Gene) and COG4 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Disulfiram (Compound) downregulates COG4 (Gene) and COG4 (Gene) is downregulated by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Disulfiram (Compound) upregulates RELB (Gene) and RELB (Gene) is downregulated by Rosuvastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Disulfiram (Compound) upregulates EGR1 (Gene) and EGR1 (Gene) is upregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Sodium aurothiomalate
Disulfiram (Compound) upregulates FOSL1 (Gene) and FOSL1 (Gene) is downregulated by Pyrimethamine (Compound) and Pyrimethamine may lead to a major life threatening interaction when taken with Sodium aurothiomalate
Disulfiram (Compound) downregulates DDB2 (Gene) and DDB2 (Gene) is upregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Sodium aurothiomalate
Disulfiram (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Pyrimethamine (Compound) and Pyrimethamine may lead to a major life threatening interaction when taken with Sodium aurothiomalate
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Vinblastine (Compound) and TUBB6 (Gene) is upregulated by Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate