DDInter1494 DDInter1694
Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval of the medication is supported by data from three double-blind, placebo-controlled trials and two open-label trials which showed that the onset of action was approximately 1.0 hour and the median time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving normal potassium levels within 48 hours following administration. The treatment effect was maintained for up to 12 months.
Posaconazole {u} (Compound) resembles {v} (Compound) Itraconazole
Posaconazole {u} (Compound) binds {v} (Gene) ABCB1
Posaconazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Posaconazole {u} (Compound) causes {v} (Side Effect) Kidney function abnormal
Posaconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium hydroxide
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Posaconazole {u} may lead to a major life threatening interaction when taken with {v} Panobinostat
Posaconazole {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Posaconazole (Compound) resembles Itraconazole (Compound)
Posaconazole (Compound) binds ABCB1 (Gene)
Posaconazole (Compound) is included by Azoles (Pharmacologic Class)
Posaconazole (Compound) causes Kidney function abnormal (Side Effect)
Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine
Posaconazole may lead to a major life threatening interaction when taken with Panobinostat
Posaconazole may lead to a major life threatening interaction when taken with Leflunomide