DDInter255 DDInter1144
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem cell transplant. It is also used to treat uveal melanoma with unresectable hepatic metastases.
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Melphalan
Busulfan {u} (Compound) downregulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is upregulated by {v} (Compound) Melphalan
Busulfan {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Melphalan
Busulfan {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Melphalan
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Busulfan {u} (Compound) downregulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is upregulated by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Busulfan {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Busulfan {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Levodopa
Levodopa {u} (Compound) resembles {v} (Compound) Melphalan
Busulfan {u} (Compound) causes {v} (Side Effect) Interstitial lung disease
Interstitial lung disease {u} (Side Effect) is caused by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Busulfan {u} (Compound) causes {v} (Side Effect) Extravasation
Extravasation {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Melphalan (Compound)
Busulfan (Compound) downregulates BLCAP (Gene) and BLCAP (Gene) is upregulated by Melphalan (Compound)
Busulfan (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Melphalan (Compound)
Busulfan (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Melphalan (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Busulfan (Compound) downregulates BLCAP (Gene) and BLCAP (Gene) is upregulated by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Busulfan (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Busulfan (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Levodopa (Compound) and Levodopa (Compound) resembles Melphalan (Compound)
Busulfan (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Busulfan (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Melphalan