DDInter458 DDInter1079
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Lisinopril was granted FDA approval on 29 December 1987.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Lisinopril
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pyelonephritis
Pyelonephritis {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Trandolapril
Trandolapril {u} (Compound) resembles {v} (Compound) Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Ear disorder
Ear disorder {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lisinopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Bursitis
Bursitis {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Lisinopril
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is downregulated by {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Lisinopril
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lisinopril (Compound)
Cyclosporine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Lisinopril (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Enalapril (Compound) and Enalapril (Compound) resembles Lisinopril (Compound)
Cyclosporine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Lisinopril (Compound)
Cyclosporine (Compound) causes Pyelonephritis (Side Effect) and Pyelonephritis (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril
Cyclosporine (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Trandolapril (Compound) and Trandolapril (Compound) resembles Lisinopril (Compound)
Cyclosporine (Compound) causes Ear disorder (Side Effect) and Ear disorder (Side Effect) is caused by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril
Cyclosporine (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Lisinopril
Cyclosporine (Compound) causes Bursitis (Side Effect) and Bursitis (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Lisinopril
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is downregulated by systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Lisinopril (Compound)