DDInter458 DDInter1547
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A pyrazine that is used therapeutically as an antitubercular agent.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pyrazinamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Pyrazinamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyrazinamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Digestion impaired
Digestion impaired {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Pyrazinamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) regulates {v} (Gene) AOX1
AOX1 {u} (Gene) is bound by {v} (Compound) Pyrazinamide
Cyclosporine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pyrazinamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyrazinamide
Cyclosporine {u} (Compound) downregulates {v} (Gene) MELK
MELK {u} (Gene) regulates {v} (Gene) PXDN
PXDN {u} (Gene) is downregulated by {v} (Compound) Pyrazinamide
Cyclosporine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyrazinamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) LMAN1
LMAN1 {u} (Gene) regulates {v} (Gene) PXDN
PXDN {u} (Gene) is downregulated by {v} (Compound) Pyrazinamide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pyrazinamide (Compound)
Cyclosporine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Pyrazinamide (Compound)
Cyclosporine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Pyrazinamide
Cyclosporine (Compound) causes Digestion impaired (Side Effect) and Digestion impaired (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Pyrazinamide
Cyclosporine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) regulates AOX1 (Gene) and AOX1 (Gene) is bound by Pyrazinamide (Compound)
Cyclosporine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pyrazinamide (Compound)
Cyclosporine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Clofarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pyrazinamide
Cyclosporine (Compound) downregulates MELK (Gene) and MELK (Gene) regulates PXDN (Gene) and PXDN (Gene) is downregulated by Pyrazinamide (Compound)
Cyclosporine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Pyrazinamide
Cyclosporine (Compound) upregulates LMAN1 (Gene) and LMAN1 (Gene) regulates PXDN (Gene) and PXDN (Gene) is downregulated by Pyrazinamide (Compound)