DDInter405 DDInter576
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Clofarabine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) upregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) downregulates {v} (Gene) C2CD5
C2CD5 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) regulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) upregulates {v} (Gene) DUSP5
DUSP5 {u} (Gene) is regulated by {v} (Gene) VPS28
VPS28 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) upregulates {v} (Gene) PPP1R15A
PPP1R15A {u} (Gene) interacts with {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Clofarabine {u} (Compound) upregulates {v} (Gene) ATF3
ATF3 {u} (Gene) interacts with {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Clofarabine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Clofarabine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is upregulated by Disulfiram (Compound)
Clofarabine (Compound) upregulates DDB2 (Gene) and DDB2 (Gene) is downregulated by Disulfiram (Compound)
Clofarabine (Compound) downregulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Disulfiram (Compound)
Clofarabine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Clofarabine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) regulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Disulfiram (Compound)
Clofarabine (Compound) upregulates DUSP5 (Gene) and DUSP5 (Gene) is regulated by VPS28 (Gene) and VPS28 (Gene) is downregulated by Disulfiram (Compound)
Clofarabine (Compound) upregulates PPP1R15A (Gene) and PPP1R15A (Gene) interacts with MYC (Gene) and MYC (Gene) is upregulated by Disulfiram (Compound)
Clofarabine (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Clofarabine (Compound) upregulates ATF3 (Gene) and ATF3 (Gene) interacts with FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)