DDInter665 DDInter1376
A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Ergotamine {u} (Compound) resembles {v} (Compound) Lisuride
Ergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Ergotamine {u} (Compound) binds {v} (Gene) DRD2
Ergotamine {u} (Compound) palliates {v} (Disease) migraine
Ergotamine {u} (Compound) is included by {v} (Pharmacologic Class) Ergotamines
Ergotamine {u} (Compound) causes {v} (Side Effect) Emotional distress
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Crizotinib
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bexarotene
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Clarithromycin
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Phenylephrine
Ergotamine (Compound) resembles Lisuride (Compound)
Ergotamine (Compound) resembles Bromocriptine (Compound)
Ergotamine (Compound) binds DRD2 (Gene)
Ergotamine (Compound) palliates migraine (Disease)
Ergotamine (Compound) is included by Ergotamines (Pharmacologic Class)
Ergotamine (Compound) causes Emotional distress (Side Effect)
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene
Ergotamine may lead to a major life threatening interaction when taken with Clarithromycin
Ergotamine may lead to a major life threatening interaction when taken with Phenylephrine