DDInter351 DDInter255
An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.[L43942,L44022]
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Chloramphenicol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) downregulates {v} (Gene) USP22
USP22 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) regulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) downregulates {v} (Gene) USP22
USP22 {u} (Gene) regulates {v} (Gene) PRKX
PRKX {u} (Gene) is upregulated by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is regulated by {v} (Gene) POLB
POLB {u} (Gene) is upregulated by {v} (Compound) Busulfan
Chloramphenicol {u} (Compound) downregulates {v} (Gene) USP22
USP22 {u} (Gene) is regulated by {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Chloramphenicol (Compound) upregulates C5 (Gene) and C5 (Gene) is upregulated by Busulfan (Compound)
Chloramphenicol (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Busulfan (Compound)
Chloramphenicol (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Busulfan (Compound)
Chloramphenicol (Compound) upregulates C5 (Gene) and C5 (Gene) regulates PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)
Chloramphenicol (Compound) downregulates USP22 (Gene) and USP22 (Gene) regulates PRKX (Gene) and PRKX (Gene) is upregulated by Busulfan (Compound)
Chloramphenicol (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)
Chloramphenicol (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Busulfan (Compound)
Chloramphenicol (Compound) upregulates C5 (Gene) and C5 (Gene) is regulated by POLB (Gene) and POLB (Gene) is upregulated by Busulfan (Compound)
Chloramphenicol (Compound) downregulates USP22 (Gene) and USP22 (Gene) is regulated by PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)