DDInter1607 DDInter1128
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]
Ritonavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mebendazole
Ritonavir {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Mebendazole
Ritonavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Albendazole
Albendazole {u} (Compound) resembles {v} (Compound) Mebendazole
Ritonavir {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) resembles {v} (Compound) Mebendazole
Ritonavir {u} (Compound) causes {v} (Side Effect) Menorrhagia
Menorrhagia {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mebendazole
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mebendazole
Ritonavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TUBA1A
TUBA1A {u} (Gene) is bound by {v} (Compound) Mebendazole
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is upregulated by {v} (Compound) Mebendazole
Ritonavir {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mebendazole
Ritonavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) SNX6
SNX6 {u} (Gene) is upregulated by {v} (Compound) Mebendazole
Ritonavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mebendazole (Compound)
Ritonavir (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Mebendazole (Compound)
Ritonavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Albendazole (Compound) and Albendazole (Compound) resembles Mebendazole (Compound)
Ritonavir (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) resembles Mebendazole (Compound)
Ritonavir (Compound) causes Menorrhagia (Side Effect) and Menorrhagia (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Mebendazole
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mebendazole (Compound)
Ritonavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TUBA1A (Gene) and TUBA1A (Gene) is bound by Mebendazole (Compound)
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is upregulated by Mebendazole (Compound)
Ritonavir (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Mebendazole
Ritonavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates SNX6 (Gene) and SNX6 (Gene) is upregulated by Mebendazole (Compound)