DDInter596 DDInter1912
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Doxorubicin {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Valganciclovir
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Acyclovir
Acyclovir {u} (Compound) resembles {v} (Compound) Valganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Penciclovir
Penciclovir {u} (Compound) resembles {v} (Compound) Valganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Viral infection
Viral infection {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valganciclovir
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Ganciclovir {u} (Compound) resembles {v} (Compound) Valganciclovir
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Ganciclovir {u} (Compound) resembles {v} (Compound) Valganciclovir
Doxorubicin {u} (Compound) upregulates {v} (Gene) OXCT1
OXCT1 {u} (Gene) is upregulated by {v} (Compound) Penciclovir
Penciclovir {u} (Compound) resembles {v} (Compound) Valganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Mucous membrane disorder
Mucous membrane disorder {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valganciclovir
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Valganciclovir
Doxorubicin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir
Doxorubicin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Acyclovir (Compound) and Acyclovir (Compound) resembles Valganciclovir (Compound)
Doxorubicin (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Penciclovir (Compound) and Penciclovir (Compound) resembles Valganciclovir (Compound)
Doxorubicin (Compound) causes Viral infection (Side Effect) and Viral infection (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Doxorubicin (Compound) upregulates OXCT1 (Gene) and OXCT1 (Gene) is upregulated by Penciclovir (Compound) and Penciclovir (Compound) resembles Valganciclovir (Compound)
Doxorubicin (Compound) causes Mucous membrane disorder (Side Effect) and Mucous membrane disorder (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)