DDInter115 DDInter899
Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Ardeparin {u} (Compound) binds {v} (Gene) SERPIND1
Ardeparin {u} (Compound) causes {v} (Side Effect) Malaise
Ardeparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegaspargase
Ardeparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Niraparib
Ardeparin {u} may lead to a major life threatening interaction when taken with {v} Defibrotide
Ardeparin {u} may lead to a major life threatening interaction when taken with {v} Eptifibatide
Ardeparin {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Fondaparinux
Ardeparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Flurbiprofen
Ardeparin (Compound) binds SERPIND1 (Gene)
Ardeparin (Compound) causes Malaise (Side Effect)
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Ardeparin may lead to a major life threatening interaction when taken with Defibrotide
Ardeparin may lead to a major life threatening interaction when taken with Eptifibatide
Ardeparin (Compound) resembles Fondaparinux (Compound) and Ardeparin may lead to a major life threatening interaction when taken with Fondaparinux
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Ardeparin may lead to a major life threatening interaction when taken with Flurbiprofen