DDInter763 DDInter1397
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Flurbiprofen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) regulates {v} (Gene) CSTA
CSTA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is regulated by {v} (Gene) DHCR24
DHCR24 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) resembles {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) resembles {v} (Compound) Clorazepic acid
Clorazepic acid {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Flurbiprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Flurbiprofen (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Flurbiprofen (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Paroxetine (Compound)
Flurbiprofen (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Flurbiprofen (Compound) downregulates GRN (Gene) and GRN (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Paroxetine (Compound)
Flurbiprofen (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) regulates CSTA (Gene) and CSTA (Gene) is upregulated by Paroxetine (Compound)
Flurbiprofen (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is regulated by DHCR24 (Gene) and DHCR24 (Gene) is upregulated by Paroxetine (Compound)
Flurbiprofen (Compound) resembles Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Paroxetine (Compound)
Flurbiprofen (Compound) resembles Clorazepic acid (Compound) and Clorazepic acid (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Paroxetine (Compound)
Flurbiprofen (Compound) resembles Fenoprofen (Compound) and Fenoprofen (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Paroxetine (Compound)