DDInter542 DDInter336
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) binds {v} (Gene) ORM1
ORM1 {u} (Gene) is bound by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) resembles {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) binds {v} (Gene) GPR35
GPR35 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) regulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) resembles {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Celecoxib (Compound)
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Celecoxib (Compound)
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfaphenazole (Compound) and Sulfaphenazole (Compound) resembles Celecoxib (Compound)
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Dicoumarol (Compound) binds GPR35 (Gene) and GPR35 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Celecoxib (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is palliated by Celecoxib (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Celecoxib (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) regulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Celecoxib (Compound)
Dicoumarol (Compound) resembles Acenocoumarol (Compound) and Acenocoumarol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Celecoxib (Compound)