DDInter671 DDInter781
Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow [FDA Label]. Epoetin alfa (Epoge) was developed by Amgen Inc. in 1983 as the first rhEPO commercialized in the United States, followed by other alfa and beta formulations. Epoetin alfa is a 165-amino acid erythropoiesis-stimulating glycoprotein produced in cell culture using recombinant DNA technology and is used for the treatment of patients with anemia associated with various clinical conditions, such as chronic renal failure, antiviral drug therapy, chemotherapy, or a high risk for perioperative blood loss from surgical procedures [FDA Label]. It has a molecular weight of approximately 30,400 daltons and is produced by mammalian cells into which the human erythropo
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Spirapril
Spirapril {u} (Compound) resembles {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trandolapril
Trandolapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moexipril
Moexipril {u} (Compound) resembles {v} (Compound) Ramipril
Ramipril {u} (Compound) resembles {v} (Compound) Fosinopril
Erythropoietin {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) causes {v} (Side Effect) Loss of consciousness
Loss of consciousness {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinapril
Quinapril {u} (Compound) resembles {v} (Compound) Spirapril
Spirapril {u} (Compound) resembles {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) binds {v} (Gene) SLC15A1
SLC15A1 {u} (Gene) is bound by {v} (Compound) Fosinopril
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Enalapril and Enalapril (Compound) resembles Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Enalapril and Enalapril (Compound) resembles Spirapril (Compound) and Spirapril (Compound) resembles Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Trandolapril and Trandolapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Moexipril and Moexipril (Compound) resembles Ramipril (Compound) and Ramipril (Compound) resembles Fosinopril (Compound)
Erythropoietin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Quinapril and Quinapril (Compound) resembles Spirapril (Compound) and Spirapril (Compound) resembles Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) binds SLC15A1 (Gene) and SLC15A1 (Gene) is bound by Fosinopril (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Fosinopril (Compound)