DDInter1570 DDInter909
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy".. The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment can be tailored specifically to the unique cancer genetics of each patient. Imatinib was approved on February 1st ,2001 by the FDA and November 7th, 2001 by the EMA; however, its European approval has been withdrawn in October 2023.[A263036,L49746,L49751]
Ranolazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Imatinib
Ranolazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is upregulated by {v} (Compound) Imatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Imatinib
Ranolazine {u} (Compound) resembles {v} (Compound) Carvedilol
Carvedilol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Imatinib
Ranolazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Imatinib
Ranolazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is regulated by {v} (Gene) KIT
KIT {u} (Gene) is bound by {v} (Compound) Imatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Imatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Meclizine
Meclizine {u} (Compound) resembles {v} (Compound) Imatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Imatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Pulmonary fibrosis
Pulmonary fibrosis {u} (Side Effect) is caused by {v} (Compound) Temozolomide
Temozolomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Imatinib
Ranolazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Imatinib (Compound)
Ranolazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Imatinib (Compound)
Ranolazine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Imatinib (Compound)
Ranolazine (Compound) resembles Carvedilol (Compound) and Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Imatinib
Ranolazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Imatinib
Ranolazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is regulated by KIT (Gene) and KIT (Gene) is bound by Imatinib (Compound)
Ranolazine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a minor interaction that can limit clinical effects when taken with Imatinib
Ranolazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Meclizine (Compound) and Meclizine (Compound) resembles Imatinib (Compound)
Ranolazine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Imatinib
Ranolazine (Compound) causes Pulmonary fibrosis (Side Effect) and Pulmonary fibrosis (Side Effect) is caused by Temozolomide (Compound) and Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Imatinib