DDInter763 DDInter1662
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Flurbiprofen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) regulates {v} (Gene) ELOVL6
ELOVL6 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) resembles {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Flurbiprofen {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is regulated by {v} (Gene) ELOVL6
ELOVL6 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Flurbiprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sertraline (Compound)
Flurbiprofen (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Sertraline (Compound)
Flurbiprofen (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sertraline (Compound)
Flurbiprofen (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Flurbiprofen (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Flurbiprofen (Compound) downregulates GRN (Gene) and GRN (Gene) regulates ELOVL6 (Gene) and ELOVL6 (Gene) is upregulated by Sertraline (Compound)
Flurbiprofen (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Flurbiprofen (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Flurbiprofen (Compound) resembles Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sertraline (Compound)
Flurbiprofen (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is regulated by ELOVL6 (Gene) and ELOVL6 (Gene) is upregulated by Sertraline (Compound)