DDInter507 DDInter248
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH. It has been employed clinically since 1972
Bumetanide is a sulfamyl diuretic.
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Bumetanide
Desmopressin {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Bumetanide
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Bumetanide
Desmopressin {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Bumetanide
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) causes {v} (Side Effect) Blood uric acid increased
Blood uric acid increased {u} (Side Effect) is caused by {v} (Compound) Bumetanide
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Bumetanide
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) regulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Bumetanide
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Bumetanide (Compound)
Desmopressin (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Bumetanide (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Bumetanide (Compound)
Desmopressin (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Bumetanide (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Indapamide (Compound) and Indapamide (Compound) resembles Bumetanide (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Bumetanide (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) causes Blood uric acid increased (Side Effect) and Blood uric acid increased (Side Effect) is caused by Bumetanide (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Bumetanide (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) regulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Bumetanide (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Bumetanide (Compound)