DDInter1852 DDInter781
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcut
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Spirapril
Spirapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Trandolapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} (Compound) causes {v} (Side Effect) Rhinitis
Rhinitis {u} (Side Effect) is caused by {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinapril
Quinapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinapril
Quinapril {u} (Compound) resembles {v} (Compound) Spirapril
Spirapril {u} (Compound) resembles {v} (Compound) Fosinopril
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Captopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Fosinopril
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Captopril {u} (Compound) binds {v} (Gene) SLC15A1
SLC15A1 {u} (Gene) is bound by {v} (Compound) Fosinopril
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Fosinopril (Compound)
Treprostinil (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Fosinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Spirapril (Compound) and Spirapril (Compound) resembles Fosinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Treprostinil (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Treprostinil (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Cilazapril (Compound) and Cilazapril (Compound) resembles Fosinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Spirapril (Compound) and Spirapril (Compound) resembles Fosinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Captopril and Captopril (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Fosinopril (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Captopril and Captopril (Compound) binds SLC15A1 (Gene) and SLC15A1 (Gene) is bound by Fosinopril (Compound)