DDInter1620 DDInter393
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Ropivacaine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) upregulates {v} (Gene) CNOT4
CNOT4 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Troleandomycin
Troleandomycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Erythromycin
Erythromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) upregulates {v} (Gene) CNOT4
CNOT4 {u} (Gene) regulates {v} (Gene) RPP38
RPP38 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) upregulates {v} (Gene) ST3GAL5
ST3GAL5 {u} (Gene) is regulated by {v} (Gene) RPP38
RPP38 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Ropivacaine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Ropivacaine {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Azithromycin
Azithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Ropivacaine {u} (Compound) causes {v} (Side Effect) Tinnitus
Tinnitus {u} (Side Effect) is caused by {v} (Compound) Erythromycin
Erythromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Ropivacaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Ropivacaine (Compound) upregulates CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Clarithromycin (Compound)
Ropivacaine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Ropivacaine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Troleandomycin (Compound) and Troleandomycin (Compound) resembles Clarithromycin (Compound)
Ropivacaine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Erythromycin (Compound) and Erythromycin (Compound) resembles Clarithromycin (Compound)
Ropivacaine (Compound) upregulates CNOT4 (Gene) and CNOT4 (Gene) regulates RPP38 (Gene) and RPP38 (Gene) is upregulated by Clarithromycin (Compound)
Ropivacaine (Compound) upregulates ST3GAL5 (Gene) and ST3GAL5 (Gene) is regulated by RPP38 (Gene) and RPP38 (Gene) is upregulated by Clarithromycin (Compound)
Ropivacaine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Ropivacaine (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Azithromycin (Compound) and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Ropivacaine (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Erythromycin (Compound) and Erythromycin (Compound) resembles Clarithromycin (Compound)