DDInter535 DDInter246
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Diazoxide {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Budesonide
Diazoxide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is upregulated by {v} (Compound) Budesonide
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) is upregulated by {v} (Compound) Budesonide
Diazoxide {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is downregulated by {v} (Compound) Budesonide
Diazoxide {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Budesonide
Diazoxide {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Budesonide
Diazoxide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Budesonide
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Budesonide
Diazoxide {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is downregulated by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Budesonide
Diazoxide {u} (Compound) downregulates {v} (Gene) C2CD5
C2CD5 {u} (Gene) regulates {v} (Gene) P4HA2
P4HA2 {u} (Gene) is upregulated by {v} (Compound) Budesonide
Diazoxide (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Budesonide (Compound)
Diazoxide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is upregulated by Budesonide (Compound)
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) is upregulated by Budesonide (Compound)
Diazoxide (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Budesonide (Compound)
Diazoxide (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Budesonide (Compound)
Diazoxide (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Budesonide (Compound)
Diazoxide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is upregulated by Betamethasone (Compound) and Betamethasone (Compound) resembles Budesonide (Compound)
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) is upregulated by Betamethasone (Compound) and Betamethasone (Compound) resembles Budesonide (Compound)
Diazoxide (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Betamethasone (Compound) and Betamethasone (Compound) resembles Budesonide (Compound)
Diazoxide (Compound) downregulates C2CD5 (Gene) and C2CD5 (Gene) regulates P4HA2 (Gene) and P4HA2 (Gene) is upregulated by Budesonide (Compound)