DDInter1358 DDInter856
Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Oxaprozin {u} (Compound) resembles {v} (Compound) Benzphetamine
Oxaprozin {u} (Compound) resembles {v} (Compound) Phenytoin
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Oxaprozin {u} (Compound) binds {v} (Gene) PTGS1
Oxaprozin {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
Oxaprozin {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Oxaprozin {u} (Compound) causes {v} (Side Effect) Glossitis
Oxaprozin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Oxaprozin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cangrelor
Oxaprozin (Compound) resembles Benzphetamine (Compound)
Oxaprozin (Compound) resembles Phenytoin (Compound)
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Oxaprozin (Compound) binds PTGS1 (Gene)
Oxaprozin (Compound) palliates rheumatoid arthritis (Disease)
Oxaprozin (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Oxaprozin (Compound) causes Glossitis (Side Effect)
Oxaprozin may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Oxaprozin may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor