DDInter1042 DDInter1063
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol (levalbuterol).
Levosalbutamol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Beclomethasone dipropionate
Levosalbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cabozantinib
Levosalbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ivosidenib
Levosalbutamol {u} may lead to a major life threatening interaction when taken with {v} Ribociclib
Levosalbutamol may cause a minor interaction that can limit clinical effects when taken with Beclomethasone dipropionate
Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Levosalbutamol may lead to a major life threatening interaction when taken with Ribociclib