DDInter1590 DDInter178
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Rifampicin {u} (Compound) resembles {v} (Compound) Rifabutin
Rifampicin {u} (Compound) treats {v} (Disease) leprosy
Rifampicin {u} (Compound) binds {v} (Gene) ABCC2
Rifampicin {u} (Compound) is included by {v} (Pharmacologic Class) Rifamycins
Rifampicin {u} (Compound) downregulates {v} (Gene) TIMP1
Rifampicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Rifampicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Rifampicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dapsone
Rifampicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aluminum hydroxide
Rifampicin {u} may lead to a major life threatening interaction when taken with {v} Elagolix
Rifampicin (Compound) resembles Rifabutin (Compound)
Rifampicin (Compound) treats leprosy (Disease)
Rifampicin (Compound) binds ABCC2 (Gene)
Rifampicin (Compound) is included by Rifamycins (Pharmacologic Class)
Rifampicin (Compound) downregulates TIMP1 (Gene)
Rifampicin may cause a minor interaction that can limit clinical effects when taken with Doxepin
Rifampicin may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Dapsone
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide
Rifampicin may lead to a major life threatening interaction when taken with Elagolix