DDInter533 DDInter1707
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Diatrizoate {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Spironolactone
Diatrizoate {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Spironolactone
Diatrizoate {u} (Compound) causes {v} (Side Effect) Renal failure acute
Renal failure acute {u} (Side Effect) is caused by {v} (Compound) Iodixanol
Iodixanol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Spironolactone
Diatrizoate {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Spironolactone
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Iodipamide {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Spironolactone
Diatrizoate {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Spironolactone
Diatrizoate {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iohexol
Iohexol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Spironolactone
Diatrizoate {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Spironolactone
Diatrizoate {u} (Compound) causes {v} (Side Effect) Sinus bradycardia
Sinus bradycardia {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may lead to a major life threatening interaction when taken with {v} Spironolactone
Diatrizoate (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Spironolactone (Compound)
Diatrizoate (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Testosterone (Compound) and Testosterone (Compound) resembles Spironolactone (Compound)
Diatrizoate (Compound) causes Renal failure acute (Side Effect) and Renal failure acute (Side Effect) is caused by Iodixanol (Compound) and Iodixanol may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone
Diatrizoate (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Spironolactone
Diatrizoate (Compound) resembles Iodipamide (Compound) and Iodipamide (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Spironolactone (Compound)
Diatrizoate (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Spironolactone (Compound)
Diatrizoate (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iohexol (Compound) and Iohexol may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone
Diatrizoate (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Morphine (Compound) and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone
Diatrizoate (Compound) causes Sinus bradycardia (Side Effect) and Sinus bradycardia (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may lead to a major life threatening interaction when taken with Spironolactone