DDInter998 DDInter1640
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a relatively benign adverse effect profile as compared to other antiretroviral therapies. While its efficacy was initially limited by exceptionally poor oral bioavailability (approximately 4%), its current indications require the co-administration of ritonavir - a potent enzyme inhibitor - that increases the bioavailability and subsequent serum concentrations of saquinavir, thus dramatically improving antiviral activity.[A214382,L3450,L14351]
Ivermectin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Saquinavir
Ivermectin {u} (Compound) upregulates {v} (Gene) SLC1A4
SLC1A4 {u} (Gene) is upregulated by {v} (Compound) Saquinavir
Ivermectin {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Saquinavir
Ivermectin {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Saquinavir
Ivermectin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Atazanavir
Atazanavir {u} (Compound) resembles {v} (Compound) Saquinavir
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Lopinavir
Lopinavir {u} (Compound) resembles {v} (Compound) Saquinavir
Ivermectin {u} (Compound) upregulates {v} (Gene) SLC1A4
SLC1A4 {u} (Gene) is upregulated by {v} (Compound) Nelfinavir
Nelfinavir {u} (Compound) resembles {v} (Compound) Saquinavir
Ivermectin {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Saquinavir
Ivermectin {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Afatinib
Afatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Saquinavir
Ivermectin {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Nelfinavir
Nelfinavir {u} (Compound) resembles {v} (Compound) Saquinavir
Ivermectin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Saquinavir (Compound)
Ivermectin (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is upregulated by Saquinavir (Compound)
Ivermectin (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Saquinavir (Compound)
Ivermectin (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Saquinavir (Compound)
Ivermectin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Atazanavir (Compound) and Atazanavir (Compound) resembles Saquinavir (Compound)
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lopinavir (Compound) and Lopinavir (Compound) resembles Saquinavir (Compound)
Ivermectin (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is upregulated by Nelfinavir (Compound) and Nelfinavir (Compound) resembles Saquinavir (Compound)
Ivermectin (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Saquinavir (Compound)
Ivermectin (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Afatinib (Compound) and Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir
Ivermectin (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Nelfinavir (Compound) and Nelfinavir (Compound) resembles Saquinavir (Compound)