DDInter763 DDInter856
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Flurbiprofen {u} (Compound) resembles {v} (Compound) L-Phenylalanine
Flurbiprofen {u} (Compound) resembles {v} (Compound) Tiaprofenic acid
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Flurbiprofen {u} (Compound) binds {v} (Gene) UGT1A1
Flurbiprofen {u} (Compound) upregulates {v} (Gene) IKBKE
Flurbiprofen {u} (Compound) palliates {v} (Disease) osteoarthritis
Flurbiprofen {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Flurbiprofen {u} (Compound) downregulates {v} (Gene) RRP12
Flurbiprofen {u} (Compound) causes {v} (Side Effect) Inflammatory bowel disease
Flurbiprofen (Compound) resembles L-Phenylalanine (Compound)
Flurbiprofen (Compound) resembles Tiaprofenic acid (Compound)
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Labetalol
Flurbiprofen (Compound) binds UGT1A1 (Gene)
Flurbiprofen (Compound) upregulates IKBKE (Gene)
Flurbiprofen (Compound) palliates osteoarthritis (Disease)
Flurbiprofen (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Flurbiprofen (Compound) downregulates RRP12 (Gene)
Flurbiprofen (Compound) causes Inflammatory bowel disease (Side Effect)