DDInter1913 DDInter336
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects of khelline when he found that all of his samples, dissolved in valproic acid, exerted a similar degree of anticonvulsive activity. It first received approval on February 28, 1978 from the FDA under the trade name Depakene. Since then, it has been investigated for neuroprotective, anti-manic, and anti-migraine effects. It is currently a compound of interest in the field of oncology for its anti-proliferative effects and is the subject of many clinical trials in a variety of cancer types.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Valproic acid {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Celecoxib
Valproic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Valproic acid {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Valproic acid {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) resembles {v} (Compound) Celecoxib
Valproic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Valproic acid {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Celecoxib
Valproic acid {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is associated with {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Valproic acid {u} (Compound) binds {v} (Gene) SLC22A5
SLC22A5 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Valproic acid {u} (Compound) binds {v} (Gene) HDAC2
HDAC2 {u} (Gene) is upregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Valproic acid {u} (Compound) binds {v} (Gene) ABAT
ABAT {u} (Gene) is downregulated by {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Valproic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Celecoxib (Compound)
Valproic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Valproic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Valproic acid (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfaphenazole (Compound) and Sulfaphenazole (Compound) resembles Celecoxib (Compound)
Valproic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Valproic acid (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Celecoxib (Compound)
Valproic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is associated with prostate cancer (Disease) and prostate cancer (Disease) is palliated by Celecoxib (Compound)
Valproic acid (Compound) binds SLC22A5 (Gene) and SLC22A5 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Celecoxib (Compound)
Valproic acid (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is upregulated by colon cancer (Disease) and colon cancer (Disease) is palliated by Celecoxib (Compound)
Valproic acid (Compound) binds ABAT (Gene) and ABAT (Gene) is downregulated by kidney cancer (Disease) and kidney cancer (Disease) is palliated by Celecoxib (Compound)