DDInter1233 DDInter1261
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system through the blood-brain barrier.
Mitotane {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Mitotane {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Amiodarone
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is downregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Mitotane {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Verapamil
Verapamil {u} may lead to a major life threatening interaction when taken with {v} Naloxegol
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Crizotinib
Crizotinib {u} may lead to a major life threatening interaction when taken with {v} Naloxegol
Mitotane {u} (Compound) causes {v} (Side Effect) Salivary hypersecretion
Salivary hypersecretion {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Nefazodone {u} may lead to a major life threatening interaction when taken with {v} Naloxegol
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ezogabine
Ezogabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eslicarbazepine
Eslicarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxegol
Mitotane {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxegol
Mitotane (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Amiodarone (Compound) and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Amiodarone (Compound) and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Mitotane (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Amiodarone (Compound) and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is downregulated by Sorafenib (Compound) and Sorafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Mitotane (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Verapamil (Compound) and Verapamil may lead to a major life threatening interaction when taken with Naloxegol
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Crizotinib (Compound) and Crizotinib may lead to a major life threatening interaction when taken with Naloxegol
Mitotane (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Nefazodone (Compound) and Nefazodone may lead to a major life threatening interaction when taken with Naloxegol
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine and Ezogabine may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Mitotane (Compound) resembles Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine and Eslicarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol
Mitotane (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol