DDInter364 DDInter1887
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, deb
Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones. Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Trovafloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may lead to a major life threatening interaction when taken with {v} Trovafloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Trovafloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glimepiride
Glimepiride {u} may lead to a major life threatening interaction when taken with {v} Trovafloxacin
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Gemifloxacin {u} (Compound) resembles {v} (Compound) Trovafloxacin
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Alcohol intolerance
Alcohol intolerance {u} (Side Effect) is caused by {v} (Compound) Glipizide
Glipizide {u} may lead to a major life threatening interaction when taken with {v} Trovafloxacin
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Aplastic anaemia
Aplastic anaemia {u} (Side Effect) is caused by {v} (Compound) Temozolomide
Temozolomide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Gemifloxacin {u} (Compound) resembles {v} (Compound) Trovafloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Gemifloxacin {u} (Compound) resembles {v} (Compound) Trovafloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Trovafloxacin
Chlorpropamide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Trovafloxacin (Compound)
Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may lead to a major life threatening interaction when taken with Trovafloxacin
Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Trovafloxacin
Chlorpropamide (Compound) resembles Glimepiride (Compound) and Glimepiride may lead to a major life threatening interaction when taken with Trovafloxacin
Chlorpropamide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Gemifloxacin (Compound) and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Chlorpropamide (Compound) causes Alcohol intolerance (Side Effect) and Alcohol intolerance (Side Effect) is caused by Glipizide (Compound) and Glipizide may lead to a major life threatening interaction when taken with Trovafloxacin
Chlorpropamide (Compound) causes Aplastic anaemia (Side Effect) and Aplastic anaemia (Side Effect) is caused by Temozolomide (Compound) and Temozolomide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Chlorpropamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Trovafloxacin