DDInter1619 DDInter600
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Ropinirole {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Ropinirole {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Doxylamine
Ropinirole {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Ropinirole {u} (Compound) causes {v} (Side Effect) Biliary colic
Biliary colic {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Ropinirole {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Doxylamine
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Doxylamine
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Ropinirole {u} (Compound) upregulates {v} (Gene) GHR
GHR {u} (Gene) is upregulated by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Doxylamine
Ropinirole {u} (Compound) downregulates {v} (Gene) STXBP2
STXBP2 {u} (Gene) is upregulated by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Doxylamine
Ropinirole {u} (Compound) downregulates {v} (Gene) STXBP2
STXBP2 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Doxylamine
Ropinirole (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxylamine (Compound)
Ropinirole (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Toremifene (Compound) and Toremifene (Compound) resembles Doxylamine (Compound)
Ropinirole (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Ropinirole (Compound) causes Biliary colic (Side Effect) and Biliary colic (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Ropinirole (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Doxylamine (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Toremifene (Compound) and Toremifene (Compound) resembles Doxylamine (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Ropinirole (Compound) upregulates GHR (Gene) and GHR (Gene) is upregulated by Toremifene (Compound) and Toremifene (Compound) resembles Doxylamine (Compound)
Ropinirole (Compound) downregulates STXBP2 (Gene) and STXBP2 (Gene) is upregulated by Toremifene (Compound) and Toremifene (Compound) resembles Doxylamine (Compound)
Ropinirole (Compound) downregulates STXBP2 (Gene) and STXBP2 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Doxylamine (Compound)