DDInter1686 DDInter1435
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Sodium citrate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Sodium citrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxacin
Sodium citrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neratinib
Sodium citrate {u} may lead to a major life threatening interaction when taken with {v} Aluminum hydroxide
Sodium citrate may cause a minor interaction that can limit clinical effects when taken with Captopril
Sodium citrate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin
Sodium citrate may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Sodium citrate may lead to a major life threatening interaction when taken with Aluminum hydroxide