DDInter128 DDInter119
Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Astemizole {u} (Compound) resembles {v} (Compound) Fentanyl
Astemizole {u} (Compound) resembles {v} (Compound) Flunarizine
Astemizole {u} may lead to a major life threatening interaction when taken with {v} Pimozide
Astemizole {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Astemizole {u} (Compound) upregulates {v} (Gene) LIPA
Astemizole {u} (Compound) downregulates {v} (Gene) RPS4Y1
Astemizole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Astemizole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Astemizole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Astemizole {u} may lead to a major life threatening interaction when taken with {v} Methadone
Astemizole (Compound) resembles Fentanyl (Compound)
Astemizole (Compound) resembles Flunarizine (Compound)
Astemizole may lead to a major life threatening interaction when taken with Pimozide
Astemizole (Compound) binds CYP3A7-CYP3A51P (Gene)
Astemizole (Compound) upregulates LIPA (Gene)
Astemizole (Compound) downregulates RPS4Y1 (Gene)
Astemizole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib
Astemizole may lead to a major life threatening interaction when taken with Methadone