DDInter472 DDInter899
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Danazol {u} (Compound) resembles {v} (Compound) Ethinylestradiol
Danazol {u} (Compound) resembles {v} (Compound) Oxandrolone
Danazol {u} (Compound) binds {v} (Gene) AR
Danazol {u} (Compound) upregulates {v} (Gene) TSKU
Danazol {u} (Compound) is included by {v} (Pharmacologic Class) Androstanes
Danazol {u} (Compound) downregulates {v} (Gene) TP53
Danazol {u} (Compound) causes {v} (Side Effect) Acne
Danazol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Danazol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Miglitol
Danazol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cobimetinib
Danazol (Compound) resembles Ethinylestradiol (Compound)
Danazol (Compound) resembles Oxandrolone (Compound)
Danazol (Compound) binds AR (Gene)
Danazol (Compound) upregulates TSKU (Gene)
Danazol (Compound) is included by Androstanes (Pharmacologic Class)
Danazol (Compound) downregulates TP53 (Gene)
Danazol (Compound) causes Acne (Side Effect)
Danazol may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Miglitol
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib