DDInter458 DDInter868
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Infant botulism is a rare infectious disease occurring in infants in which _Clostridium botulinum_ colonize the large intestine and being to produce botulinum neurotoxin directly in the gut. As these neurotoxins interfere with cholinergic nervous transmission, patients initially present with evident of loss of muscle tone (e.g. constipation, ptosis, feeding difficulties) which may progress to more serious symptoms such as respiratory arrest and flaccid paralysis.[L39819,L39824] BabyBIG (human-derived botulism immunoglobulin) was approved for use by the FDA in 2003 and has since been used to treat more than 2100 cases of infant botulism. It is produced and distributed by the Calfornia Department of Public Health's Infant Botulism Treatment and Prevention Program and comprises IgG antibodies derived from pooled adult plasma from persons immunized with recombinant botulinum vaccine who have high titers of neutralizing antibodies against botulinum toxin.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Pentamidine
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is treated by {v} (Compound) Methotrexate
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) downregulates {v} (Gene) DHFR
DHFR {u} (Gene) is bound by {v} (Compound) Methotrexate
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TIMELESS
TIMELESS {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine {u} (Compound) binds {v} (Gene) PPIF
PPIF {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Pentamidine (Compound) and Pentamidine may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is treated by Methotrexate (Compound) and Methotrexate may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) downregulates DHFR (Gene) and DHFR (Gene) is bound by Methotrexate (Compound) and Methotrexate may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) downregulates TIMELESS (Gene) and TIMELESS (Gene) is upregulated by Methotrexate (Compound) and Methotrexate may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Cyclosporine (Compound) binds PPIF (Gene) and PPIF (Gene) is downregulated by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin