DDInter387 DDInter255
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Cisplatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Cisplatin {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Cisplatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Cisplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is associated with {v} (Gene) CHEK2
CHEK2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) TP53BP2
TP53BP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cisplatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Cisplatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) WASF3
WASF3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Cisplatin (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Cisplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) is associated with CHEK2 (Gene) and CHEK2 (Gene) is downregulated by Busulfan (Compound)
Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates TP53BP2 (Gene) and TP53BP2 (Gene) is upregulated by Busulfan (Compound)
Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Busulfan (Compound)
Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates WASF3 (Gene) and WASF3 (Gene) is upregulated by Busulfan (Compound)