DDInter685 DDInter154
Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a safer alternative to other drugs used for insomnia. One major benefit of eszopiclone is that it is approved by the FDA for the long-term treatment of insomnia. This sets it apart from many other hypnotic sedatives, which are generally approved only for the relief of short-term (6-8 weeks) insomnia. Eszopiclone was initially approved by the FDA in 2004.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Eszopiclone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Eszopiclone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Azelastine
Eszopiclone {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Eszopiclone {u} (Compound) causes {v} (Side Effect) Dermatitis contact
Dermatitis contact {u} (Side Effect) is caused by {v} (Compound) Azelastine
Eszopiclone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Eszopiclone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Azelastine
Eszopiclone {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) regulates {v} (Gene) PLCB3
PLCB3 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Eszopiclone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Eszopiclone {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Eszopiclone {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) regulates {v} (Gene) CANT1
CANT1 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Eszopiclone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Azelastine (Compound)
Eszopiclone (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Azelastine (Compound)
Eszopiclone (Compound) causes Dermatitis contact (Side Effect) and Dermatitis contact (Side Effect) is caused by Azelastine (Compound)
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Eszopiclone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Clozapine (Compound) and Clozapine (Compound) resembles Azelastine (Compound)
Eszopiclone (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) regulates PLCB3 (Gene) and PLCB3 (Gene) is upregulated by Azelastine (Compound)
Eszopiclone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Eszopiclone (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is palliated by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Eszopiclone (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) regulates CANT1 (Gene) and CANT1 (Gene) is downregulated by Azelastine (Compound)