DDInter154 DDInter1778
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) upregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is downregulated by {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetrabenazine
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Donepezil {u} (Compound) resembles {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) upregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is regulated by {v} (Gene) IPO13
IPO13 {u} (Gene) is downregulated by {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is regulated by {v} (Gene) CBR1
CBR1 {u} (Gene) is bound by {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} (Compound) resembles {v} (Compound) Tetrabenazine
Azelastine {u} (Compound) causes {v} (Side Effect) Upper respiratory tract infection
Upper respiratory tract infection {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetrabenazine
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Azelastine (Compound) upregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Tetrabenazine (Compound)
Azelastine (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Tetrabenazine (Compound)
Azelastine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Tetrabenazine (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound) and Donepezil (Compound) resembles Tetrabenazine (Compound)
Azelastine (Compound) upregulates PROS1 (Gene) and PROS1 (Gene) is regulated by IPO13 (Gene) and IPO13 (Gene) is downregulated by Tetrabenazine (Compound)
Azelastine (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is regulated by CBR1 (Gene) and CBR1 (Gene) is bound by Tetrabenazine (Compound)
Azelastine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Donepezil (Compound) and Donepezil (Compound) resembles Tetrabenazine (Compound)
Azelastine (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tetrabenazine