DDInter1304 DDInter1376
Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina. Nitroglycerin causes vasodilation in both arteries and veins. Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure, and chronic anal fissure. It is also used to induce intraoperative hypotension.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Nitroglycerin {u} (Compound) resembles {v} (Compound) Erythrityl Tetranitrate
Nitroglycerin {u} (Compound) binds {v} (Gene) GUCY1B3
Nitroglycerin {u} (Compound) palliates {v} (Disease) coronary artery disease
Nitroglycerin {u} (Compound) is included by {v} (Pharmacologic Class) Vasodilation
Nitroglycerin {u} (Compound) causes {v} (Side Effect) Visual impairment
Nitroglycerin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atropine
Nitroglycerin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mepenzolate
Nitroglycerin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Nitroglycerin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dapsone
Nitroglycerin {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Nitroglycerin (Compound) resembles Erythrityl Tetranitrate (Compound)
Nitroglycerin (Compound) binds GUCY1B3 (Gene)
Nitroglycerin (Compound) palliates coronary artery disease (Disease)
Nitroglycerin (Compound) is included by Vasodilation (Pharmacologic Class)
Nitroglycerin (Compound) causes Visual impairment (Side Effect)
Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Atropine
Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Mepenzolate
Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Opium
Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Dapsone
Nitroglycerin may lead to a major life threatening interaction when taken with Nitrous acid