DDInter162 DDInter1155
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorphenesin
Chlorphenesin {u} (Compound) resembles {v} (Compound) Bisoprolol
Bisoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eplerenone
Eplerenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) binds {v} (Gene) GABBR2
GABBR2 {u} (Gene) regulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Mepyramine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenytoin
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Quazepam
Quazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) is included by {v} (Pharmacologic Class) GABA A Agonists
GABA A Agonists {u} (Pharmacologic Class) includes {v} (Compound) Zaleplon
Zaleplon {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Aclidinium
Aclidinium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) resembles Chlorphenesin (Compound) and Chlorphenesin (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) binds GABBR2 (Gene) and GABBR2 (Gene) regulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Mepyramine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Quazepam (Compound) and Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) is included by GABA A Agonists (Pharmacologic Class) and GABA A Agonists (Pharmacologic Class) includes Zaleplon (Compound) and Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Baclofen (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Aclidinium (Compound) and Aclidinium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine