DDInter48 DDInter1005
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout. It was initially approved by the FDA in 1966 and is now formulated by several manufacturers.
Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate.
Allopurinol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Sotalol
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Allopurinol {u} (Compound) causes {v} (Side Effect) Vasodilation procedure
Vasodilation procedure {u} (Side Effect) is caused by {v} (Compound) Meperidine
Meperidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kaolin
Allopurinol {u} (Compound) causes {v} (Side Effect) Throat sore
Throat sore {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kaolin
Allopurinol {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Dolutegravir
Dolutegravir {u} may lead to a major life threatening interaction when taken with {v} Kaolin
Allopurinol {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Nebivolol
Nebivolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Allopurinol {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Carvedilol
Carvedilol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Allopurinol {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Oxytetracycline
Oxytetracycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kaolin
Allopurinol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Allopurinol (Compound) causes Vasodilation procedure (Side Effect) and Vasodilation procedure (Side Effect) is caused by Meperidine (Compound) and Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Allopurinol (Compound) causes Throat sore (Side Effect) and Throat sore (Side Effect) is caused by Hydroxychloroquine (Compound) and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Allopurinol (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dolutegravir (Compound) and Dolutegravir may lead to a major life threatening interaction when taken with Kaolin
Allopurinol (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nebivolol (Compound) and Nebivolol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Allopurinol (Compound) binds XDH (Gene) and XDH (Gene) is bound by Carvedilol (Compound) and Carvedilol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Allopurinol (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Oxytetracycline (Compound) and Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Kaolin