DDInter1397 DDInter908
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties.
Paroxetine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Bimatoprost
Bimatoprost {u} (Compound) resembles {v} (Compound) Iloprost
Paroxetine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Tadalafil
Tadalafil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Iloprost
Paroxetine {u} (Compound) causes {v} (Side Effect) Urine abnormality
Urine abnormality {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Escitalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Paroxetine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Trandolapril
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Paroxetine {u} (Compound) causes {v} (Side Effect) Conjunctival oedema
Conjunctival oedema {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Iloprost
Paroxetine {u} (Compound) causes {v} (Side Effect) Keratitis
Keratitis {u} (Side Effect) is caused by {v} (Compound) Tizanidine
Tizanidine {u} may lead to a major life threatening interaction when taken with {v} Iloprost
Paroxetine {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is regulated by {v} (Gene) PDE4D
PDE4D {u} (Gene) is bound by {v} (Compound) Iloprost
Paroxetine {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Clopidogrel
Clopidogrel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Paroxetine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) covaries with {v} (Gene) SLCO3A1
SLCO3A1 {u} (Gene) is bound by {v} (Compound) Iloprost
Paroxetine {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Iloprost
Paroxetine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Bimatoprost (Compound) and Bimatoprost (Compound) resembles Iloprost (Compound)
Paroxetine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Tadalafil (Compound) and Tadalafil may cause a minor interaction that can limit clinical effects when taken with Iloprost
Paroxetine (Compound) causes Urine abnormality (Side Effect) and Urine abnormality (Side Effect) is caused by Escitalopram (Compound) and Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Paroxetine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Trandolapril (Compound) and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Paroxetine (Compound) causes Conjunctival oedema (Side Effect) and Conjunctival oedema (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Iloprost
Paroxetine (Compound) causes Keratitis (Side Effect) and Keratitis (Side Effect) is caused by Tizanidine (Compound) and Tizanidine may lead to a major life threatening interaction when taken with Iloprost
Paroxetine (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is regulated by PDE4D (Gene) and PDE4D (Gene) is bound by Iloprost (Compound)
Paroxetine (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Clopidogrel (Compound) and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Paroxetine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) covaries with SLCO3A1 (Gene) and SLCO3A1 (Gene) is bound by Iloprost (Compound)
Paroxetine (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Iloprost