DDInter655 DDInter596
An anthracycline which is the 4&#39;-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Epirubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) resembles {v} (Compound) Valrubicin
Valrubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) treats {v} (Disease) stomach cancer
stomach cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) upregulates {v} (Gene) P4HA2
P4HA2 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) is included by {v} (Pharmacologic Class) Anthracyclines
Anthracyclines {u} (Pharmacologic Class) includes {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) downregulates {v} (Gene) TSKU
TSKU {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) CHD1
CHD1 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Epirubicin {u} (Compound) causes {v} (Side Effect) Mucous membrane disorder
Mucous membrane disorder {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Epirubicin (Compound) resembles Doxorubicin (Compound)
Epirubicin (Compound) resembles Daunorubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Epirubicin (Compound) resembles Valrubicin (Compound) and Valrubicin (Compound) resembles Doxorubicin (Compound)
Epirubicin (Compound) treats stomach cancer (Disease) and stomach cancer (Disease) is treated by Doxorubicin (Compound)
Epirubicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Doxorubicin (Compound)
Epirubicin (Compound) upregulates P4HA2 (Gene) and P4HA2 (Gene) is upregulated by Doxorubicin (Compound)
Epirubicin (Compound) is included by Anthracyclines (Pharmacologic Class) and Anthracyclines (Pharmacologic Class) includes Doxorubicin (Compound)
Epirubicin (Compound) downregulates TSKU (Gene) and TSKU (Gene) is downregulated by Doxorubicin (Compound)
Epirubicin (Compound) binds CHD1 (Gene) and Epirubicin (Compound) downregulates CHD1 (Gene) and CHD1 (Gene) is downregulated by Doxorubicin (Compound)
Epirubicin (Compound) causes Mucous membrane disorder (Side Effect) and Mucous membrane disorder (Side Effect) is caused by Doxorubicin (Compound)