DDInter1853 DDInter1783
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml. Other formulations of tetracycline continue to be used.
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tetracycline
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Tetracycline
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Tetracycline
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxycycline
Doxycycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Demeclocycline
Demeclocycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tretinoin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) is bound by {v} (Compound) Minocycline
Minocycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Demeclocycline
Demeclocycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tretinoin {u} (Compound) upregulates {v} (Gene) NCOA3
NCOA3 {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Tetracycline
Tretinoin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) is upregulated by {v} (Compound) Digoxin
Digoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracycline
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Acetazolamide
Acetazolamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tetracycline (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Iso
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Tetracycline
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound) and Doxycycline (Compound) resembles Tetracycline (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Isotretinoin may lead to a major life threatening interaction when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Tretinoin (Compound) upregulates IL1B (Gene) and IL1B (Gene) is bound by Minocycline (Compound) and Minocycline (Compound) resembles Tetracycline (Compound)
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Tretinoin (Compound) upregulates NCOA3 (Gene) and NCOA3 (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Tetracycline (Compound)
Tretinoin (Compound) upregulates IL1B (Gene) and IL1B (Gene) is upregulated by Digoxin (Compound) and Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Acetazolamide (Compound) and Acetazolamide may cause a minor interaction that can limit clinical effects when taken with Tetracycline