DDInter1619 DDInter245
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tolterodine
Tolterodine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Ropinirole {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) regulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Brompheniramine
Ropinirole {u} (Compound) binds {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Captodiame
Captodiame {u} (Compound) resembles {v} (Compound) Brompheniramine
Ropinirole {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Ropinirole {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Brompheniramine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Brompheniramine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is regulated by {v} (Gene) CHRM3
CHRM3 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Brompheniramine
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Brompheniramine (Compound)
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tolterodine (Compound) and Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Ropinirole (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) regulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Brompheniramine (Compound)
Ropinirole (Compound) binds HTR2C (Gene) and HTR2C (Gene) is bound by Captodiame (Compound) and Captodiame (Compound) resembles Brompheniramine (Compound)
Ropinirole (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Ropinirole (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Brompheniramine (Compound)
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Brompheniramine (Compound)
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is regulated by CHRM3 (Gene) and CHRM3 (Gene) is bound by Brompheniramine (Compound)
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Brompheniramine (Compound)