DDInter1158 DDInter25
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.
Mesalazine {u} (Compound) binds {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Acyclovir
Mesalazine {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Acyclovir
Mesalazine {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Acyclovir
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acyclovir
Mesalazine {u} (Compound) binds {v} (Gene) IKBKB
IKBKB {u} (Gene) regulates {v} (Gene) GFOD1
GFOD1 {u} (Gene) is upregulated by {v} (Compound) Acyclovir
Mesalazine {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Acyclovir
Mesalazine {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Memantine
Memantine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acyclovir
Mesalazine {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Valganciclovir
Valganciclovir {u} (Compound) resembles {v} (Compound) Acyclovir
Mesalazine {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Valaciclovir
Valaciclovir {u} (Compound) resembles {v} (Compound) Acyclovir
Mesalazine {u} (Compound) causes {v} (Side Effect) Thrombocytosis
Thrombocytosis {u} (Side Effect) is caused by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acyclovir
Mesalazine (Compound) binds IKBKB (Gene) and IKBKB (Gene) is upregulated by Acyclovir (Compound)
Mesalazine (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Acyclovir (Compound)
Mesalazine (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Acyclovir (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Acyclovir
Mesalazine (Compound) binds IKBKB (Gene) and IKBKB (Gene) regulates GFOD1 (Gene) and GFOD1 (Gene) is upregulated by Acyclovir (Compound)
Mesalazine (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Acyclovir (Compound)
Mesalazine (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Memantine (Compound) and Memantine may cause a minor interaction that can limit clinical effects when taken with Acyclovir
Mesalazine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Valganciclovir (Compound) and Valganciclovir (Compound) resembles Acyclovir (Compound)
Mesalazine (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Valaciclovir (Compound) and Valaciclovir (Compound) resembles Acyclovir (Compound)
Mesalazine (Compound) causes Thrombocytosis (Side Effect) and Thrombocytosis (Side Effect) is caused by Mycophenolate mofetil (Compound) and Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Acyclovir