DDInter301 DDInter535
Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with both aspirin and codeine [FDA label, F4060, F4069]. In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Carisoprodol {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Carisoprodol {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Carisoprodol {u} (Compound) resembles {v} (Compound) Meprobamate
Meprobamate {u} (Compound) causes {v} (Side Effect) Lymphadenopathy
Lymphadenopathy {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Bortezomib {u} (Compound) upregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Bortezomib {u} (Compound) upregulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Bortezomib {u} (Compound) downregulates {v} (Gene) LYPLA1
LYPLA1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Carisoprodol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Alimemazine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Carisoprodol (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Diazoxide (Compound)
Carisoprodol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Carisoprodol (Compound) resembles Meprobamate (Compound) and Meprobamate (Compound) causes Lymphadenopathy (Side Effect) and Lymphadenopathy (Side Effect) is caused by Diazoxide (Compound)
Carisoprodol may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib (Compound) upregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Diazoxide (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Diazoxide (Compound)
Carisoprodol may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib (Compound) upregulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide and Trimethobenzamide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Diazoxide (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Carisoprodol may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib (Compound) downregulates LYPLA1 (Gene) and LYPLA1 (Gene) is downregulated by Diazoxide (Compound)
Carisoprodol may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Diazoxide (Compound)