DDInter411 DDInter1376
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. Unfortunately
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Clonazepam {u} (Compound) resembles {v} (Compound) Cloxazolam
Clonazepam {u} (Compound) resembles {v} (Compound) Diazepam
Clonazepam {u} (Compound) treats {v} (Disease) epilepsy syndrome
Clonazepam {u} (Compound) binds {v} (Gene) NAT2
Clonazepam {u} (Compound) palliates {v} (Disease) multiple sclerosis
Clonazepam {u} (Compound) is included by {v} (Pharmacologic Class) Benzodiazepines
Clonazepam {u} (Compound) causes {v} (Side Effect) Increased appetite
Clonazepam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Clonazepam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Clonazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rilonacept
Clonazepam (Compound) resembles Cloxazolam (Compound)
Clonazepam (Compound) resembles Diazepam (Compound)
Clonazepam (Compound) treats epilepsy syndrome (Disease)
Clonazepam (Compound) binds NAT2 (Gene)
Clonazepam (Compound) palliates multiple sclerosis (Disease)
Clonazepam (Compound) is included by Benzodiazepines (Pharmacologic Class)
Clonazepam (Compound) causes Increased appetite (Side Effect)
Clonazepam may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Clonazepam may cause a minor interaction that can limit clinical effects when taken with Theophylline
Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept