DDInter1764 DDInter781
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Spirapril
Spirapril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Trandolapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxetine
Fluoxetine {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Stevens-Johnson syndrome {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Ramipril
Ramipril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) binds {v} (Gene) SLC15A1
SLC15A1 {u} (Gene) is bound by {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinapril
Quinapril {u} (Compound) resembles {v} (Compound) Spirapril
Spirapril {u} (Compound) resembles {v} (Compound) Fosinopril
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Spirapril (Compound) and Spirapril (Compound) resembles Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Ramipril (Compound) and Ramipril (Compound) resembles Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) binds SLC15A1 (Gene) and SLC15A1 (Gene) is bound by Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Fosinopril (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Spirapril (Compound) and Spirapril (Compound) resembles Fosinopril (Compound)