DDInter85 DDInter704
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Amphotericin B {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Everolimus
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Amphotericin B {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Tacrolimus
Tacrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Amphotericin B {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Amphotericin B {u} (Compound) resembles {v} (Compound) Natamycin
Natamycin {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Everolimus
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) binds {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is bound by {v} (Compound) Everolimus
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) upregulates {v} (Gene) BTG1
BTG1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is upregulated by {v} (Compound) Everolimus
Amphotericin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Amphotericin B (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Everolimus (Compound)
Amphotericin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Amphotericin B (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Tacrolimus (Compound) and Tacrolimus (Compound) resembles Everolimus (Compound)
Amphotericin B (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Amphotericin B (Compound) resembles Natamycin (Compound) and Natamycin (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Everolimus (Compound)
Amphotericin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Amphotericin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) binds FKBP1A (Gene) and FKBP1A (Gene) is bound by Everolimus (Compound)
Amphotericin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) upregulates BTG1 (Gene) and BTG1 (Gene) is upregulated by Everolimus (Compound)
Amphotericin B may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) downregulates PNP (Gene) and PNP (Gene) is upregulated by Everolimus (Compound)