DDInter856 DDInter511
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271] MDD is a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and 12.8% in Europe. Although the exact mechanism of pathophysiology is still unknown, imbalances or deficiencies of monoamines have been heavily implicated, thus the rationale behind the use of SNRI to treat MDD. Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine]. The major difference is the potential for drug interaction since venlafaxine is mainly metabolized by CYP2D6 while desvenlafaxine is conjugated by UGT; therefore, desvenlafaxine is less likely to cause drug-drug interaction when taken with medications affecting the CYP2D6 pathway.
Desvenlafaxine {u} (Compound) resembles {v} (Compound) Cyclopentolate
Desvenlafaxine {u} (Compound) binds {v} (Gene) SLC6A2
Desvenlafaxine {u} (Compound) is included by {v} (Pharmacologic Class) Serotonin Uptake Inhibitors
Desvenlafaxine {u} (Compound) causes {v} (Side Effect) Hot flush
Desvenlafaxine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium sulfate
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Desvenlafaxine {u} may lead to a major life threatening interaction when taken with {v} Dextromethorphan
Desvenlafaxine {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Iobenguane
Desvenlafaxine (Compound) resembles Cyclopentolate (Compound)
Desvenlafaxine (Compound) binds SLC6A2 (Gene)
Desvenlafaxine (Compound) is included by Serotonin Uptake Inhibitors (Pharmacologic Class)
Desvenlafaxine (Compound) causes Hot flush (Side Effect)
Desvenlafaxine may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Urea
Desvenlafaxine may lead to a major life threatening interaction when taken with Dextromethorphan
Desvenlafaxine may lead to a major life threatening interaction when taken with Methylene blue
Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Desvenlafaxine may lead to a major life threatening interaction when taken with Iobenguane