DDInter1226 DDInter1376
A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Minoxidil {u} (Compound) treats {v} (Disease) hypertension
Minoxidil {u} (Compound) binds {v} (Gene) KCNJ1
Minoxidil {u} (Compound) upregulates {v} (Gene) CDK6
Minoxidil {u} (Compound) is included by {v} (Pharmacologic Class) Arteriolar Vasodilation
Minoxidil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexmedetomidine
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Minoxidil {u} may lead to a major life threatening interaction when taken with {v} Guanethidine
Minoxidil {u} may lead to a major life threatening interaction when taken with {v} Guanadrel
Minoxidil (Compound) treats hypertension (Disease)
Minoxidil (Compound) binds KCNJ1 (Gene)
Minoxidil (Compound) upregulates CDK6 (Gene)
Minoxidil (Compound) is included by Arteriolar Vasodilation (Pharmacologic Class)
Minoxidil may cause a minor interaction that can limit clinical effects when taken with Tadalafil
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dexmedetomidine
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline
Minoxidil may lead to a major life threatening interaction when taken with Guanethidine
Minoxidil may lead to a major life threatening interaction when taken with Guanadrel