DDInter1968 DDInter336
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid was first described in the literature in 1994. Zoledronic acid was granted FDA approval on 20 August 2001.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Zoledronic acid {u} (Compound) binds {v} (Gene) CA14
CA14 {u} (Gene) is bound by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is associated with {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) resembles {v} (Compound) Clodronate
Clodronate {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) resembles {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) causes {v} (Side Effect) Nasopharyngitis
Nasopharyngitis {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) resembles {v} (Compound) Ibandronate
Ibandronate {u} (Compound) causes {v} (Side Effect) Renal failure acute
Renal failure acute {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Zoledronic acid {u} (Compound) treats {v} (Disease) Paget's disease of bone
Paget's disease of bone {u} (Disease) resembles {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Celecoxib
Zoledronic acid (Compound) binds CA14 (Gene) and CA14 (Gene) is bound by Celecoxib (Compound)
Zoledronic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Zoledronic acid (Compound) binds CA2 (Gene) and CA2 (Gene) is associated with kidney cancer (Disease) and kidney cancer (Disease) is palliated by Celecoxib (Compound)
Zoledronic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Zoledronic acid (Compound) resembles Clodronate (Compound) and Clodronate (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Zoledronic acid (Compound) binds CA2 (Gene) and CA2 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Celecoxib (Compound)
Zoledronic acid (Compound) resembles Pamidronic acid (Compound) and Pamidronic acid (Compound) causes Nasopharyngitis (Side Effect) and Nasopharyngitis (Side Effect) is caused by Celecoxib (Compound)
Zoledronic acid (Compound) resembles Ibandronate (Compound) and Ibandronate (Compound) causes Renal failure acute (Side Effect) and Renal failure acute (Side Effect) is caused by Celecoxib (Compound)
Zoledronic acid (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Zoledronic acid (Compound) treats Paget's disease of bone (Disease) and Paget's disease of bone (Disease) resembles osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Celecoxib (Compound)