DDInter1887 DDInter1853
Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones. Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Trovafloxacin {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Gemifloxacin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} (Compound) upregulates {v} (Gene) CEBPA
CEBPA {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) BRCA1
BRCA1 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) RXRA
RXRA {u} (Gene) is bound by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) resembles {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) downregulates {v} (Gene) IGFBP2
IGFBP2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Trovafloxacin (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Tretinoin (Compound)
Trovafloxacin (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Trovafloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Tretinoin (Compound)
Trovafloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin (Compound) upregulates CEBPA (Gene) and CEBPA (Gene) is downregulated by Tretinoin (Compound)
Trovafloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Tretinoin (Compound)
Trovafloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Tretinoin (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with BRCA1 (Gene) and BRCA1 (Gene) is upregulated by Tretinoin (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is regulated by RXRA (Gene) and RXRA (Gene) is bound by Tretinoin (Compound)
Trovafloxacin (Compound) resembles Ciprofloxacin (Compound) and Ciprofloxacin (Compound) downregulates IGFBP2 (Gene) and IGFBP2 (Gene) is downregulated by Tretinoin (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is regulated by C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tretinoin (Compound)