DDInter1666 DDInter1791
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Theophylline
Sildenafil {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Theophylline
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Caffeine
Caffeine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Sildenafil {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Theobromine
Theobromine {u} (Compound) resembles {v} (Compound) Theophylline
Sildenafil {u} (Compound) binds {v} (Gene) PDE5A
PDE5A {u} (Gene) is bound by {v} (Compound) Dipyridamole
Dipyridamole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Sildenafil {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Caffeine
Caffeine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Sildenafil {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Dyphylline
Dyphylline {u} (Compound) resembles {v} (Compound) Theophylline
Sildenafil {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Theobromine
Theobromine {u} (Compound) resembles {v} (Compound) Theophylline
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Alprazolam
Alprazolam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Sildenafil {u} (Compound) causes {v} (Side Effect) Blood uric acid increased
Blood uric acid increased {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Theophylline (Compound)
Sildenafil (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Theophylline (Compound)
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Caffeine (Compound) and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline
Sildenafil (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Theobromine (Compound) and Theobromine (Compound) resembles Theophylline (Compound)
Sildenafil (Compound) binds PDE5A (Gene) and PDE5A (Gene) is bound by Dipyridamole (Compound) and Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Theophylline
Sildenafil (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Caffeine (Compound) and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline
Sildenafil (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dyphylline (Compound) and Dyphylline (Compound) resembles Theophylline (Compound)
Sildenafil (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Theobromine (Compound) and Theobromine (Compound) resembles Theophylline (Compound)
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Alprazolam (Compound) and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline
Sildenafil (Compound) causes Blood uric acid increased (Side Effect) and Blood uric acid increased (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Theophylline