DDInter743 DDInter1620
Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) downregulates {v} (Gene) HOXA5
HOXA5 {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Ropivacaine
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Levobupivacaine
Levobupivacaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) regulates {v} (Gene) PRR7
PRR7 {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Fluconazole {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is regulated by {v} (Gene) NSDHL
NSDHL {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine (Compound) resembles Ropivacaine (Compound)
Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ropivacaine (Compound)
Fluconazole (Compound) downregulates HOXA5 (Gene) and HOXA5 (Gene) is downregulated by Ropivacaine (Compound)
Fluconazole (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Ropivacaine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine (Compound) resembles Levobupivacaine (Compound) and Levobupivacaine (Compound) resembles Ropivacaine (Compound)
Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lidocaine (Compound) and Lidocaine (Compound) resembles Ropivacaine (Compound)
Fluconazole (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) regulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Ropivacaine (Compound)
Fluconazole (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Lidocaine (Compound) and Lidocaine (Compound) resembles Ropivacaine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine (Compound) resembles Bupivacaine (Compound) and Bupivacaine (Compound) resembles Ropivacaine (Compound)
Fluconazole (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is regulated by NSDHL (Gene) and NSDHL (Gene) is downregulated by Ropivacaine (Compound)