DDInter895 DDInter1055
Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus. The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect. Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Hydroxyzine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) resembles {v} (Compound) Nefazodone
Nefazodone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) resembles {v} (Compound) Nefazodone
Nefazodone {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) resembles {v} (Compound) Meclizine
Meclizine {u} (Compound) downregulates {v} (Gene) PTPRO
PTPRO {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) resembles {v} (Compound) Zuclopenthixol
Zuclopenthixol {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) resembles {v} (Compound) Quetiapine
Quetiapine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Hydroxyzine {u} (Compound) resembles {v} (Compound) Quetiapine
Quetiapine {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Hydroxyzine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cyclizine {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Hydroxyzine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Levofloxacin (Compound)
Hydroxyzine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Hydroxyzine (Compound) resembles Nefazodone (Compound) and Nefazodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Hydroxyzine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Hydroxyzine (Compound) resembles Nefazodone (Compound) and Nefazodone (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Hydroxyzine (Compound) resembles Meclizine (Compound) and Meclizine (Compound) downregulates PTPRO (Gene) and PTPRO (Gene) is downregulated by Levofloxacin (Compound)
Hydroxyzine (Compound) resembles Zuclopenthixol (Compound) and Zuclopenthixol (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Levofloxacin (Compound)
Hydroxyzine (Compound) resembles Quetiapine (Compound) and Quetiapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Hydroxyzine (Compound) resembles Quetiapine (Compound) and Quetiapine (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Levofloxacin (Compound)