DDInter998 DDInter1627
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) downregulates {v} (Gene) AKT1
AKT1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) downregulates {v} (Gene) HARS
HARS {u} (Gene) interacts with {v} (Gene) SCN1A
SCN1A {u} (Gene) is bound by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) downregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) upregulates {v} (Gene) TARS
TARS {u} (Gene) interacts with {v} (Gene) SCN1A
SCN1A {u} (Gene) is bound by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) downregulates {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ivermectin {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Ivermectin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Ivermectin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Ivermectin (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Ivermectin (Compound) downregulates AKT1 (Gene) and AKT1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Ivermectin (Compound) downregulates HARS (Gene) and HARS (Gene) interacts with SCN1A (Gene) and SCN1A (Gene) is bound by Rufinamide (Compound)
Ivermectin (Compound) downregulates PSMD2 (Gene) and PSMD2 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Ivermectin (Compound) upregulates TARS (Gene) and TARS (Gene) interacts with SCN1A (Gene) and SCN1A (Gene) is bound by Rufinamide (Compound)
Ivermectin (Compound) downregulates PGRMC1 (Gene) and PGRMC1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Ivermectin (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)