DDInter1340 DDInter576
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Omeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) downregulates {v} (Gene) TRAPPC3
TRAPPC3 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) downregulates {v} (Gene) TRAPPC3
TRAPPC3 {u} (Gene) regulates {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) binds {v} (Gene) CYP11A1
CYP11A1 {u} (Gene) is upregulated by {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Rabeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) downregulates {v} (Gene) TRAPPC3
TRAPPC3 {u} (Gene) is regulated by {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Omeprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Rabeprazole {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Omeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Omeprazole (Compound) downregulates TRAPPC3 (Gene) and TRAPPC3 (Gene) is downregulated by Disulfiram (Compound)
Omeprazole (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Omeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Omeprazole (Compound) downregulates TRAPPC3 (Gene) and TRAPPC3 (Gene) regulates DNAJB2 (Gene) and DNAJB2 (Gene) is upregulated by Disulfiram (Compound)
Omeprazole (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) is upregulated by alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Omeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Omeprazole (Compound) downregulates TRAPPC3 (Gene) and TRAPPC3 (Gene) is regulated by TNFAIP3 (Gene) and TNFAIP3 (Gene) is upregulated by Disulfiram (Compound)
Omeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Omeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Disulfiram (Compound)