DDInter998 DDInter1215
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).
Ivermectin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) upregulates {v} (Gene) ECH1
ECH1 {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) downregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mifepristone
Ivermectin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) IL1B
IL1B {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) upregulates {v} (Gene) ECH1
ECH1 {u} (Gene) regulates {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) upregulates {v} (Gene) AARS
AARS {u} (Gene) is regulated by {v} (Gene) CAT
CAT {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Ivermectin {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Ivermectin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Mifepristone (Compound)
Ivermectin (Compound) upregulates ECH1 (Gene) and ECH1 (Gene) is upregulated by Mifepristone (Compound)
Ivermectin (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Mifepristone (Compound)
Ivermectin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Ivermectin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone
Ivermectin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates IL1B (Gene) and IL1B (Gene) is upregulated by Mifepristone (Compound)
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Mifepristone (Compound)
Ivermectin (Compound) upregulates ECH1 (Gene) and ECH1 (Gene) regulates PNP (Gene) and PNP (Gene) is downregulated by Mifepristone (Compound)
Ivermectin (Compound) upregulates AARS (Gene) and AARS (Gene) is regulated by CAT (Gene) and CAT (Gene) is upregulated by Mifepristone (Compound)
Ivermectin (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Mifepristone (Compound)