DDInter458 DDInter1936
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TUBB4B
TUBB4B {u} (Gene) is bound by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) downregulates {v} (Gene) ASF1B
ASF1B {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KLHDC2
KLHDC2 {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Vincristine
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TUBB4B
TUBB4B {u} (Gene) is bound by {v} (Compound) Vincristine
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Vinblastine (Compound)
Cyclosporine (Compound) downregulates TUBB4B (Gene) and TUBB4B (Gene) is bound by Vinblastine (Compound)
Cyclosporine (Compound) downregulates PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Vinblastine (Compound)
Cyclosporine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Vinblastine (Compound)
Cyclosporine (Compound) downregulates ASF1B (Gene) and ASF1B (Gene) is downregulated by Vinblastine (Compound)
Cyclosporine (Compound) upregulates KLHDC2 (Gene) and KLHDC2 (Gene) is downregulated by Vinblastine (Compound)
Cyclosporine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Vinblastine (Compound)
Cyclosporine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Vinblastine (Compound) and TUBB6 (Gene) is upregulated by Vinblastine (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Vincristine (Compound) and Vincristine (Compound) resembles Vinblastine (Compound)
Cyclosporine (Compound) downregulates TUBB4B (Gene) and TUBB4B (Gene) is bound by Vincristine (Compound) and Vincristine (Compound) resembles Vinblastine (Compound)