DDInter136 DDInter1845
Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products.[A251660,L42840] Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters.[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Atropine is a relatively inexpensive drug and
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Tranylcypromine
Atropine {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Tranylcypromine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} may lead to a major life threatening interaction when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Phenol
Phenol {u} (Compound) resembles {v} (Compound) Tranylcypromine
Atropine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine (Compound) resembles Tranylcypromine (Compound)
Atropine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Tranylcypromine (Compound)
Atropine (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Tranylcypromine (Compound)
Atropine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine may lead to a major life threatening interaction when taken with Phentermine and Phentermine (Compound) resembles Tranylcypromine (Compound)
Atropine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)
Atropine (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)
Atropine (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Tranylcypromine (Compound)
Atropine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Tranylcypromine (Compound)
Atropine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Tranylcypromine (Compound)
Atropine may cause a minor interaction that can limit clinical effects when taken with Phenelzine and Phenelzine (Compound) resembles Phenol (Compound) and Phenol (Compound) resembles Tranylcypromine (Compound)