DDInter1158 DDInter804
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for reasons other than safety or effectiveness. Apart from cancer-related hypercalcemia, gallium nitrate has been studied in arthritis, autoimmune disorders, and tumours.
Mesalazine {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Gallium nitrate
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gallium nitrate
Mesalazine {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Clofarabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gallium nitrate
Mesalazine {u} (Compound) causes {v} (Side Effect) Tinnitus
Tinnitus {u} (Side Effect) is caused by {v} (Compound) Amphotericin B
Amphotericin B {u} may lead to a major life threatening interaction when taken with {v} Gallium nitrate
Mesalazine {u} (Compound) downregulates {v} (Gene) TERF2IP
TERF2IP {u} (Gene) regulates {v} (Gene) RRM2
RRM2 {u} (Gene) is bound by {v} (Compound) Gallium nitrate
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gallium nitrate
Mesalazine {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) is regulated by {v} (Gene) RRM2
RRM2 {u} (Gene) is bound by {v} (Compound) Gallium nitrate
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exenatide
Exenatide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gallium nitrate
Mesalazine {u} (Compound) downregulates {v} (Gene) TERF2IP
TERF2IP {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gallium nitrate
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} (Compound) resembles {v} (Compound) Sulfasalazine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gallium nitrate
Mesalazine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Gallium nitrate (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Mesalazine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Clofarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Mesalazine (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Amphotericin B (Compound) and Amphotericin B may lead to a major life threatening interaction when taken with Gallium nitrate
Mesalazine (Compound) downregulates TERF2IP (Gene) and TERF2IP (Gene) regulates RRM2 (Gene) and RRM2 (Gene) is bound by Gallium nitrate (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Mesalazine (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is regulated by RRM2 (Gene) and RRM2 (Gene) is bound by Gallium nitrate (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Mesalazine (Compound) downregulates TERF2IP (Gene) and TERF2IP (Gene) is upregulated by Clofarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine (Compound) resembles Sulfasalazine (Compound) and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate