DDInter1852 DDInter1397
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcut
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Treprostinil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) downregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) downregulates {v} (Gene) GRWD1
GRWD1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) upregulates {v} (Gene) KIF2C
KIF2C {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) downregulates {v} (Gene) LIPA
LIPA {u} (Gene) regulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) upregulates {v} (Gene) NFIL3
NFIL3 {u} (Gene) is regulated by {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) upregulates {v} (Gene) GOLGB1
GOLGB1 {u} (Gene) interacts with {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Treprostinil {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) regulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Treprostinil (Compound) downregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Treprostinil (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Paroxetine (Compound)
Treprostinil (Compound) downregulates GRWD1 (Gene) and GRWD1 (Gene) is downregulated by Paroxetine (Compound)
Treprostinil (Compound) upregulates KIF2C (Gene) and KIF2C (Gene) is downregulated by Paroxetine (Compound)
Treprostinil (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Paroxetine (Compound)
Treprostinil (Compound) downregulates LIPA (Gene) and LIPA (Gene) regulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Treprostinil (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is regulated by HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Paroxetine (Compound)
Treprostinil (Compound) upregulates GOLGB1 (Gene) and GOLGB1 (Gene) interacts with SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)
Treprostinil (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) regulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Paroxetine (Compound)