DDInter1844 DDInter604
Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as drospirenone exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be considered when assessing potential risks of hormonal contraceptive use.
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Drospirenone
Tranexamic acid {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Tranexamic acid {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Drospirenone
Tranexamic acid {u} (Compound) causes {v} (Side Effect) Cerebrovascular accident
Cerebrovascular accident {u} (Side Effect) is caused by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Drospirenone
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Formestane
Formestane {u} (Compound) resembles {v} (Compound) Drospirenone
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Norethisterone
Norethisterone {u} (Compound) binds {v} (Gene) PGR
PGR {u} (Gene) is bound by {v} (Compound) Drospirenone
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Norethisterone
Norethisterone {u} (Compound) palliates {v} (Disease) polycystic ovary syndrome
polycystic ovary syndrome {u} (Disease) is palliated by {v} (Compound) Drospirenone
Tranexamic acid {u} may lead to a major life threatening interaction when taken with {v} Norethisterone
Norethisterone {u} (Compound) is included by {v} (Pharmacologic Class) Progesterone Congeners
Progesterone Congeners {u} (Pharmacologic Class) includes {v} (Compound) Drospirenone
Tranexamic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) resembles Drospirenone (Compound)
Tranexamic acid (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Drospirenone (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) resembles Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Tranexamic acid (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Drospirenone (Compound)
Tranexamic acid (Compound) causes Cerebrovascular accident (Side Effect) and Cerebrovascular accident (Side Effect) is caused by Testosterone (Compound) and Testosterone (Compound) resembles Drospirenone (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) resembles Formestane (Compound) and Formestane (Compound) resembles Drospirenone (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) binds PGR (Gene) and PGR (Gene) is bound by Drospirenone (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) palliates polycystic ovary syndrome (Disease) and polycystic ovary syndrome (Disease) is palliated by Drospirenone (Compound)
Tranexamic acid may lead to a major life threatening interaction when taken with Norethisterone and Norethisterone (Compound) is included by Progesterone Congeners (Pharmacologic Class) and Progesterone Congeners (Pharmacologic Class) includes Drospirenone (Compound)