DDInter596 DDInter813
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
Doxorubicin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Congestive cardiomyopathy
Congestive cardiomyopathy {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Bilirubin total increased
Bilirubin total increased {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Doxorubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Doxorubicin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Gemifloxacin (Compound)
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Doxorubicin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Doxorubicin (Compound) causes Congestive cardiomyopathy (Side Effect) and Congestive cardiomyopathy (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Doxorubicin (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gemifloxacin (Compound)
Doxorubicin (Compound) causes Bilirubin total increased (Side Effect) and Bilirubin total increased (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Doxorubicin (Compound) binds TOP2A (Gene) and Doxorubicin (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)