DDInter895 DDInter1016
Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus. The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect. Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Hydroxyzine {u} (Compound) resembles {v} (Compound) Anileridine
Hydroxyzine {u} (Compound) resembles {v} (Compound) Quetiapine
Hydroxyzine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Hydroxyzine {u} (Compound) binds {v} (Gene) HRH1
Hydroxyzine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine Receptor Antagonists
Hydroxyzine {u} (Compound) causes {v} (Side Effect) Drowsiness
Hydroxyzine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Hydroxyzine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Hydroxyzine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terfenadine
Hydroxyzine {u} may lead to a major life threatening interaction when taken with {v} Macimorelin
Hydroxyzine (Compound) resembles Anileridine (Compound)
Hydroxyzine (Compound) resembles Quetiapine (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Hydroxyzine (Compound) binds HRH1 (Gene)
Hydroxyzine (Compound) is included by Histamine Receptor Antagonists (Pharmacologic Class)
Hydroxyzine (Compound) causes Drowsiness (Side Effect)
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine
Hydroxyzine may lead to a major life threatening interaction when taken with Macimorelin