DDInter162 DDInter527
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Dextromethorphan
Baclofen {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Dextromethorphan
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) resembles {v} (Disease) amyotrophic lateral sclerosis
amyotrophic lateral sclerosis {u} (Disease) is palliated by {v} (Compound) Dextromethorphan
Baclofen {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Levorphanol
Levorphanol {u} (Compound) resembles {v} (Compound) Dextromethorphan
Baclofen {u} (Compound) causes {v} (Side Effect) Digestion impaired
Digestion impaired {u} (Side Effect) is caused by {v} (Compound) Propafenone
Propafenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Clonazepam
Clonazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Baclofen {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Dextromethorphan (Compound)
Baclofen (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Dextromethorphan (Compound)
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) resembles amyotrophic lateral sclerosis (Disease) and amyotrophic lateral sclerosis (Disease) is palliated by Dextromethorphan (Compound)
Baclofen (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Levorphanol (Compound) and Levorphanol (Compound) resembles Dextromethorphan (Compound)
Baclofen (Compound) causes Digestion impaired (Side Effect) and Digestion impaired (Side Effect) is caused by Propafenone (Compound) and Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Clonazepam (Compound) and Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Baclofen (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dextromethorphan (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dextromethorphan (Compound)