DDInter336 DDInter1013
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Labetalol
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tolterodine
Tolterodine {u} (Compound) resembles {v} (Compound) Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Salmeterol
Salmeterol {u} may lead to a major life threatening interaction when taken with {v} Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Loss of consciousness
Loss of consciousness {u} (Side Effect) is caused by {v} (Compound) Benazepril
Benazepril {u} (Compound) resembles {v} (Compound) Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Hepatic necrosis
Hepatic necrosis {u} (Side Effect) is caused by {v} (Compound) Tioguanine
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Drug eruption
Drug eruption {u} (Side Effect) is caused by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Formoterol
Formoterol {u} may lead to a major life threatening interaction when taken with {v} Labetalol
Celecoxib {u} (Compound) causes {v} (Side Effect) Cardiac failure
Cardiac failure {u} (Side Effect) is caused by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a minor interaction that can limit clinical effects when taken with {v} Labetalol
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Labetalol (Compound)
Celecoxib (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Labetalol (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tolterodine (Compound) and Tolterodine (Compound) resembles Labetalol (Compound)
Celecoxib (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Labetalol (Compound)
Celecoxib (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Salmeterol (Compound) and Salmeterol may lead to a major life threatening interaction when taken with Labetalol
Celecoxib (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Benazepril (Compound) and Benazepril (Compound) resembles Labetalol (Compound)
Celecoxib (Compound) causes Hepatic necrosis (Side Effect) and Hepatic necrosis (Side Effect) is caused by Tioguanine (Compound) and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol
Celecoxib (Compound) causes Drug eruption (Side Effect) and Drug eruption (Side Effect) is caused by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Labetalol
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Formoterol (Compound) and Formoterol may lead to a major life threatening interaction when taken with Labetalol
Celecoxib (Compound) causes Cardiac failure (Side Effect) and Cardiac failure (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Labetalol