DDInter485 DDInter178
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Valrubicin
Daunorubicin {u} (Compound) treats {v} (Disease) hematologic cancer
Daunorubicin {u} (Compound) binds {v} (Gene) CYP1A2
Daunorubicin {u} (Compound) upregulates {v} (Gene) GDI1
Daunorubicin {u} (Compound) is included by {v} (Pharmacologic Class) Topoisomerase Inhibitors
Daunorubicin {u} (Compound) downregulates {v} (Gene) TAF5
Daunorubicin {u} (Compound) causes {v} (Side Effect) Sickness
Daunorubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Daunorubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enoxacin
Daunorubicin (Compound) resembles Doxorubicin (Compound)
Daunorubicin (Compound) resembles Valrubicin (Compound)
Daunorubicin (Compound) treats hematologic cancer (Disease)
Daunorubicin (Compound) binds CYP1A2 (Gene)
Daunorubicin (Compound) upregulates GDI1 (Gene)
Daunorubicin (Compound) is included by Topoisomerase Inhibitors (Pharmacologic Class)
Daunorubicin (Compound) downregulates TAF5 (Gene)
Daunorubicin (Compound) causes Sickness (Side Effect)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Enoxacin