DDInter1259 DDInter1252
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. This regimen can be used in place of the older anti-proliferative [azathioprine] due to its stronger immunosuppressive potency. However, mycophenolic acid treatment is more expensive and requires therapeutic drug monitoring to optimize efficacy and minimize toxicity.[A249180,A249185] Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine. [Mycophenolate mofetil], a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.
Nalidixic acid {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) is downregulated by {v} (Compound) Mycophenolic acid
Nalidixic acid {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Nalidixic acid {u} (Compound) resembles {v} (Compound) Lomefloxacin
Lomefloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Nalidixic acid {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Nalidixic acid {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) regulates {v} (Gene) GAA
GAA {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Nalidixic acid {u} (Compound) downregulates {v} (Gene) ABCF1
ABCF1 {u} (Gene) is regulated by {v} (Gene) INPP1
INPP1 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Nalidixic acid {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} (Compound) resembles {v} (Compound) Mycophenolic acid
Nalidixic acid {u} (Compound) causes {v} (Side Effect) Swelling
Swelling {u} (Side Effect) is caused by {v} (Compound) Iron
Iron {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mycophenolic acid
Nalidixic acid {u} (Compound) resembles {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Nalidixic acid {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Nalidixic acid (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) is downregulated by Mycophenolic acid (Compound)
Nalidixic acid (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Mycophenolic acid (Compound)
Nalidixic acid (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Nalidixic acid (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Nalidixic acid (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) regulates GAA (Gene) and GAA (Gene) is upregulated by Mycophenolic acid (Compound)
Nalidixic acid (Compound) downregulates ABCF1 (Gene) and ABCF1 (Gene) is regulated by INPP1 (Gene) and INPP1 (Gene) is upregulated by Mycophenolic acid (Compound)
Nalidixic acid (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Mycophenolate mofetil (Compound) and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Nalidixic acid (Compound) causes Swelling (Side Effect) and Swelling (Side Effect) is caused by Iron (Compound) and Iron may cause a minor interaction that can limit clinical effects when taken with Mycophenolic acid
Nalidixic acid (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Mycophenolic acid (Compound)
Nalidixic acid (Compound) resembles Enoxacin (Compound) and Enoxacin (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Mycophenolic acid (Compound)