DDInter1834 DDInter593
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter indication was presented by Pernix Therapeutics.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Elevated mood
Elevated mood {u} (Side Effect) is caused by {v} (Compound) Doxepin
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Elevated mood
Elevated mood {u} (Side Effect) is caused by {v} (Compound) Amantadine
Amantadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Thiothixene {u} (Compound) resembles {v} (Compound) Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Hypomania
Hypomania {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Levodopa
Levodopa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Alanine aminotransferase increased
Alanine aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Estradiol
Estradiol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Hypoaesthesia oral
Hypoaesthesia oral {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Aripiprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Topiramate {u} (Compound) causes {v} (Side Effect) Ageusia
Ageusia {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxepin (Compound)
Topiramate (Compound) causes Elevated mood (Side Effect) and Elevated mood (Side Effect) is caused by Doxepin (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Topiramate (Compound) causes Elevated mood (Side Effect) and Elevated mood (Side Effect) is caused by Amantadine (Compound) and Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Topiramate (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Thiothixene (Compound) and Thiothixene (Compound) resembles Doxepin (Compound)
Topiramate (Compound) causes Hypomania (Side Effect) and Hypomania (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Doxepin (Compound)
Topiramate (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Levodopa (Compound) and Levodopa may cause a minor interaction that can limit clinical effects when taken with Doxepin
Topiramate (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Estradiol (Compound) and Estradiol may cause a minor interaction that can limit clinical effects when taken with Doxepin
Topiramate (Compound) causes Hypoaesthesia oral (Side Effect) and Hypoaesthesia oral (Side Effect) is caused by Aripiprazole (Compound) and Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Topiramate (Compound) causes Ageusia (Side Effect) and Ageusia (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine may lead to a major life threatening interaction when taken with Doxepin