DDInter1818 DDInter856
Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Tirofiban {u} (Compound) treats {v} (Disease) coronary artery disease
Tirofiban {u} (Compound) binds {v} (Gene) ITGA2B
Tirofiban {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Platelet Aggregation
Tirofiban {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Tirofiban {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capsicum
Tirofiban {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Tirofiban {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Icosapent
Tirofiban {u} may lead to a major life threatening interaction when taken with {v} Anistreplase
Tirofiban {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Tirofiban (Compound) treats coronary artery disease (Disease)
Tirofiban (Compound) binds ITGA2B (Gene)
Tirofiban (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class)
Tirofiban (Compound) causes Hypersensitivity (Side Effect)
Tirofiban may cause a minor interaction that can limit clinical effects when taken with Capsicum
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Icosapent
Tirofiban may lead to a major life threatening interaction when taken with Anistreplase
Tirofiban may lead to a major life threatening interaction when taken with Dasatinib