DDInter458 DDInter48
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals . Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout . It was initially approved by the FDA in 1966 and is now formulated by several manufacturers .
Cyclosporine {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) resembles {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Allopurinol
Cyclosporine {u} (Compound) downregulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is associated with {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Allopurinol
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is associated with {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Allopurinol
Cyclosporine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) regulates {v} (Gene) AOX1
AOX1 {u} (Gene) is bound by {v} (Compound) Allopurinol
Cyclosporine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Allopurinol (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) resembles gout (Disease) and gout (Disease) is treated by Allopurinol (Compound)
Cyclosporine (Compound) downregulates HPRT1 (Gene) and HPRT1 (Gene) is associated with gout (Disease) and gout (Disease) is treated by Allopurinol (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is associated with gout (Disease) and gout (Disease) is treated by Allopurinol (Compound)
Cyclosporine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) regulates AOX1 (Gene) and AOX1 (Gene) is bound by Allopurinol (Compound)