DDInter1091 DDInter1658
Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Loratadine {u} (Compound) resembles {v} (Compound) Desloratadine
Loratadine {u} (Compound) resembles {v} (Compound) Ketotifen
Loratadine {u} (Compound) treats {v} (Disease) asthma
Loratadine {u} (Compound) binds {v} (Gene) CYP3A4
Loratadine {u} (Compound) upregulates {v} (Gene) DDIT4
Loratadine {u} (Compound) downregulates {v} (Gene) TUBB6
Loratadine {u} (Compound) causes {v} (Side Effect) Syncope
Loratadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Loratadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Loratadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Loratadine (Compound) resembles Desloratadine (Compound)
Loratadine (Compound) resembles Ketotifen (Compound)
Loratadine (Compound) treats asthma (Disease)
Loratadine (Compound) binds CYP3A4 (Gene)
Loratadine (Compound) upregulates DDIT4 (Gene)
Loratadine (Compound) downregulates TUBB6 (Gene)
Loratadine (Compound) causes Syncope (Side Effect)
Loratadine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Loratadine may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine