DDInter1298 DDInter1652
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Nisoldipine {u} (Compound) resembles {v} (Compound) Nimodipine
Nisoldipine {u} (Compound) resembles {v} (Compound) Amlodipine
Nisoldipine {u} (Compound) treats {v} (Disease) hypertension
Nisoldipine {u} (Compound) binds {v} (Gene) ABCB1
Nisoldipine {u} (Compound) upregulates {v} (Gene) HMOX1
Nisoldipine {u} (Compound) is included by {v} (Pharmacologic Class) Dihydropyridines
Nisoldipine {u} (Compound) downregulates {v} (Gene) CDC20
Nisoldipine {u} (Compound) causes {v} (Side Effect) Weight decreased
Nisoldipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Nisoldipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Nisoldipine (Compound) resembles Nimodipine (Compound)
Nisoldipine (Compound) resembles Amlodipine (Compound)
Nisoldipine (Compound) treats hypertension (Disease)
Nisoldipine (Compound) binds ABCB1 (Gene)
Nisoldipine (Compound) upregulates HMOX1 (Gene)
Nisoldipine (Compound) is included by Dihydropyridines (Pharmacologic Class)
Nisoldipine (Compound) downregulates CDC20 (Gene)
Nisoldipine (Compound) causes Weight decreased (Side Effect)
Nisoldipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Nisoldipine may cause a minor interaction that can limit clinical effects when taken with Theophylline