DDInter477 DDInter1252
Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal tryptophan covalently bonded to decanoic acid.[A231374, L32534] Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil samples from Mount Ararat in Turkey. Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed d
Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. This regimen can be used in place of the older anti-proliferative [azathioprine] due to its stronger immunosuppressive potency. However, mycophenolic acid treatment is more expensive and requires therapeutic drug monitoring to optimize efficacy and minimize toxicity.[A249180,A249185] Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine. [Mycophenolate mofetil], a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.
Mycophenolic acid {u} (Compound) resembles {v} (Compound) Mycophenolate mofetil
Mycophenolic acid {u} (Compound) treats {v} (Disease) systemic scleroderma
Mycophenolic acid {u} (Compound) binds {v} (Gene) IMPDH1
Mycophenolic acid {u} (Compound) upregulates {v} (Gene) UBE2L6
Mycophenolic acid {u} (Compound) downregulates {v} (Gene) SETD5
Mycophenolic acid {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ethotoin
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zinc gluconate
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tigecycline
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Candida albicans
Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound)
Mycophenolic acid (Compound) treats systemic scleroderma (Disease)
Mycophenolic acid (Compound) binds IMPDH1 (Gene)
Mycophenolic acid (Compound) upregulates UBE2L6 (Gene)
Mycophenolic acid (Compound) downregulates SETD5 (Gene)
Mycophenolic acid (Compound) causes Nervous system disorder (Side Effect)
Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ethotoin
Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Tigecycline
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans