DDInter1226 DDInter1639
A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Minoxidil {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Minoxidil {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) is regulated by {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sapropterin
Minoxidil {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) regulates {v} (Gene) SATB1
SATB1 {u} (Gene) is upregulated by {v} (Compound) Sapropterin
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} (Compound) upregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Minoxidil {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) regulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Dexamethasone {u} (Compound) upregulates {v} (Gene) SATB1
SATB1 {u} (Gene) is upregulated by {v} (Compound) Sapropterin
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sapropterin
Minoxidil {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) is regulated by {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Treprostinil {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sapropterin
Minoxidil (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)
Minoxidil (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is regulated by NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Sapropterin (Compound)
Minoxidil (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) regulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Sapropterin (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) upregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Sapropterin (Compound)
Minoxidil (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) regulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Sapropterin (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Sapropterin (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sapropterin (Compound)
Minoxidil (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is regulated by BAG3 (Gene) and BAG3 (Gene) is downregulated by Sapropterin (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sapropterin (Compound)