DDInter1232 DDInter1938
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discovered that work via this alkylating mechanism, making mitomycin relatively unique in the space of microbiota-derived therapies. Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper Tract Urothelial Cancer (LG-UTUC) - as well as adjunctly to _ab externo_ glaucoma surgeries.
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Mitomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Mitomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Mitomycin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Vincristine
Mitomycin {u} (Compound) upregulates {v} (Gene) TICAM1
TICAM1 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Mitomycin {u} (Compound) downregulates {v} (Gene) GRB10
GRB10 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Mitomycin {u} (Compound) upregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Mitomycin {u} (Compound) downregulates {v} (Gene) UBE2C
UBE2C {u} (Gene) is downregulated by {v} (Compound) Vincristine
Mitomycin {u} (Compound) causes {v} (Side Effect) Extravasation
Extravasation {u} (Side Effect) is caused by {v} (Compound) Vincristine
Mitomycin {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Vincristine
Mitomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Voacamine
Voacamine {u} (Compound) resembles {v} (Compound) Vincristine
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine (Compound) resembles Vincristine (Compound)
Mitomycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Vincristine (Compound)
Mitomycin (Compound) upregulates TICAM1 (Gene) and TICAM1 (Gene) is upregulated by Vincristine (Compound)
Mitomycin (Compound) downregulates GRB10 (Gene) and GRB10 (Gene) is upregulated by Vincristine (Compound)
Mitomycin (Compound) upregulates PSMB8 (Gene) and PSMB8 (Gene) is downregulated by Vincristine (Compound)
Mitomycin (Compound) downregulates UBE2C (Gene) and UBE2C (Gene) is downregulated by Vincristine (Compound)
Mitomycin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Vincristine (Compound)
Mitomycin (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Vincristine (Compound) and TUBB6 (Gene) is upregulated by Vincristine (Compound)
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Voacamine (Compound) and Voacamine (Compound) resembles Vincristine (Compound)