DDInter255 DDInter1835
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Topotecan
Busulfan {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is upregulated by {v} (Compound) Topotecan
Busulfan {u} (Compound) upregulates {v} (Gene) TERT
TERT {u} (Gene) is upregulated by {v} (Compound) Topotecan
Busulfan {u} (Compound) downregulates {v} (Gene) ASCC3
ASCC3 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Busulfan {u} (Compound) upregulates {v} (Gene) TP53BP2
TP53BP2 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Busulfan {u} (Compound) causes {v} (Side Effect) Mucosal inflammation
Mucosal inflammation {u} (Side Effect) is caused by {v} (Compound) Topotecan
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Irinotecan
Irinotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Busulfan {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is regulated by {v} (Gene) TOP1
TOP1 {u} (Gene) is bound by {v} (Compound) Topotecan
Busulfan {u} (Compound) upregulates {v} (Gene) TERT
TERT {u} (Gene) is associated with {v} (Disease) cervical cancer
cervical cancer {u} (Disease) is treated by {v} (Compound) Topotecan
Busulfan {u} (Compound) downregulates {v} (Gene) OXCT1
OXCT1 {u} (Gene) regulates {v} (Gene) EGF
EGF {u} (Gene) is upregulated by {v} (Compound) Topotecan
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Topotecan (Compound)
Busulfan (Compound) downregulates SPR (Gene) and SPR (Gene) is upregulated by Topotecan (Compound)
Busulfan (Compound) upregulates TERT (Gene) and TERT (Gene) is upregulated by Topotecan (Compound)
Busulfan (Compound) downregulates ASCC3 (Gene) and ASCC3 (Gene) is downregulated by Topotecan (Compound)
Busulfan (Compound) upregulates TP53BP2 (Gene) and TP53BP2 (Gene) is downregulated by Topotecan (Compound)
Busulfan (Compound) causes Mucosal inflammation (Side Effect) and Mucosal inflammation (Side Effect) is caused by Topotecan (Compound)
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound) and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Busulfan (Compound) downregulates SPR (Gene) and SPR (Gene) is regulated by TOP1 (Gene) and TOP1 (Gene) is bound by Topotecan (Compound)
Busulfan (Compound) upregulates TERT (Gene) and TERT (Gene) is associated with cervical cancer (Disease) and cervical cancer (Disease) is treated by Topotecan (Compound)
Busulfan (Compound) downregulates OXCT1 (Gene) and OXCT1 (Gene) regulates EGF (Gene) and EGF (Gene) is upregulated by Topotecan (Compound)