DDInter1683 DDInter1435
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Sodium bicarbonate {u} (Compound) resembles {v} (Compound) Acetic acid
Sodium bicarbonate {u} (Compound) binds {v} (Gene) SLC4A10
Sodium bicarbonate {u} (Compound) causes {v} (Side Effect) Metabolic alkalosis
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Sodium bicarbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Demeclocycline
Sodium bicarbonate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Choline salicylate
Sodium bicarbonate {u} may lead to a major life threatening interaction when taken with {v} Dolutegravir
Sodium bicarbonate (Compound) resembles Acetic acid (Compound)
Sodium bicarbonate (Compound) binds SLC4A10 (Gene)
Sodium bicarbonate (Compound) causes Metabolic alkalosis (Side Effect)
Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Dexamethasone
Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Sodium bicarbonate may lead to a major life threatening interaction when taken with Dolutegravir