DDInter336 DDInter965
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent.
Celecoxib {u} (Compound) causes {v} (Side Effect) Angina pectoris
Angina pectoris {u} (Side Effect) is caused by {v} (Compound) Amiloride
Amiloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Hepatic function abnormal {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Triamterene
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Cisplatin
Cisplatin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Kanamycin
Kanamycin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Bepridil
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Sulfasalazine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is downregulated by {v} (Compound) Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is downregulated by {v} (Compound) Bacitracin
Bacitracin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Celecoxib (Compound) causes Angina pectoris (Side Effect) and Angina pectoris (Side Effect) is caused by Amiloride (Compound) and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Celecoxib (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Iothalamic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Triamterene (Compound) and Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Cisplatin (Compound) and Cisplatin may lead to a major life threatening interaction when taken with Iothalamic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Kanamycin (Compound) and Kanamycin may lead to a major life threatening interaction when taken with Iothalamic acid
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound) and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulfasalazine (Compound) and PTGS2 (Gene) is upregulated by Sulfasalazine (Compound) and Sulfasalazine may lead to a major life threatening interaction when taken with Iothalamic acid
Celecoxib (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is downregulated by Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Celecoxib (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is downregulated by Bacitracin (Compound) and Bacitracin may lead to a major life threatening interaction when taken with Iothalamic acid
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid