DDInter562 DDInter1544
Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and dizziness caused by motion sickness.[L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline. The antiemetic properties of dimenhydrinate are primarily thought to be produced by diphenhydramine
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Dimenhydrinate {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Dimenhydrinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Dimenhydrinate {u} (Compound) treats {v} (Disease) allergic rhinitis
Dimenhydrinate {u} (Compound) binds {v} (Gene) HRH1
Dimenhydrinate {u} (Compound) palliates {v} (Disease) schizophrenia
Dimenhydrinate {u} (Compound) causes {v} (Side Effect) Lassitude
Dimenhydrinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Dimenhydrinate {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Dimenhydrinate (Compound) resembles Bromodiphenhydramine (Compound)
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Dimenhydrinate (Compound) treats allergic rhinitis (Disease)
Dimenhydrinate (Compound) binds HRH1 (Gene)
Dimenhydrinate (Compound) palliates schizophrenia (Disease)
Dimenhydrinate (Compound) causes Lassitude (Side Effect)
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Dimenhydrinate may lead to a major life threatening interaction when taken with Potassium chloride