DDInter596 DDInter489
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Doxorubicin {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Deferiprone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Deferiprone
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Doxorubicin {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is regulated by {v} (Gene) BTK
BTK {u} (Gene) is upregulated by {v} (Compound) Deferiprone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Deferiprone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Connective tissue disorder
Connective tissue disorder {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Deferiprone
Doxorubicin {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is regulated by {v} (Gene) UGT1A6
UGT1A6 {u} (Gene) is bound by {v} (Compound) Deferiprone
Doxorubicin {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Multi-organ failure
Multi-organ failure {u} (Side Effect) is caused by {v} (Compound) Carfilzomib
Carfilzomib {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Doxorubicin (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Doxorubicin (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Deferiprone (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may lead to a major life threatening interaction when taken with Deferiprone
Doxorubicin (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is regulated by BTK (Gene) and BTK (Gene) is upregulated by Deferiprone (Compound)
Doxorubicin (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Doxorubicin (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Deferiprone
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Doxorubicin (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is regulated by UGT1A6 (Gene) and UGT1A6 (Gene) is bound by Deferiprone (Compound)
Doxorubicin (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Azacitidine (Compound) and Azacitidine may lead to a major life threatening interaction when taken with Deferiprone
Doxorubicin (Compound) causes Multi-organ failure (Side Effect) and Multi-organ failure (Side Effect) is caused by Carfilzomib (Compound) and Carfilzomib may lead to a major life threatening interaction when taken with Deferiprone