DDInter1725 DDInter69
Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into [mesalazine] and [sulfapyridine], 2 compounds that carry out the main pharmacological activity of sulfasalazine. Sulfasalazine was first used in 1940 for rheumatic polyarthritis, and has been firmly established itself as one fo the most useful disease-modifying antirheumatic drug (DMARD). Compared to the first line treatment of RA like methotrexate, sulfasalazine is almost as efficacious as methotrexate although with slightly less tolerability. However, sulfasalazine has less teratogenic side effects and faster onset of action compared to conventional DMARD. Sulf
A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
Sulfasalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Sulfasalazine {u} (Compound) resembles {v} (Compound) Balsalazide
Sulfasalazine {u} (Compound) treats {v} (Disease) ankylosing spondylitis
Sulfasalazine {u} (Compound) binds {v} (Gene) SLC46A1
Sulfasalazine {u} (Compound) upregulates {v} (Gene) GPATCH8
Sulfasalazine {u} (Compound) is included by {v} (Pharmacologic Class) Aminosalicylic Acids
Sulfasalazine {u} (Compound) downregulates {v} (Gene) ITGAE
Sulfasalazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levomefolic acid
Sulfasalazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Folic acid
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Asparaginase Escherichia coli
Sulfasalazine (Compound) resembles Olsalazine (Compound)
Sulfasalazine (Compound) resembles Balsalazide (Compound)
Sulfasalazine (Compound) treats ankylosing spondylitis (Disease)
Sulfasalazine (Compound) binds SLC46A1 (Gene)
Sulfasalazine (Compound) upregulates GPATCH8 (Gene)
Sulfasalazine (Compound) is included by Aminosalicylic Acids (Pharmacologic Class)
Sulfasalazine (Compound) downregulates ITGAE (Gene)
Sulfasalazine may cause a minor interaction that can limit clinical effects when taken with Levomefolic acid
Sulfasalazine may cause a minor interaction that can limit clinical effects when taken with Folic acid
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli