DDInter466 DDInter875
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and self-assembled into VLPs.
Dactinomycin {u} (Compound) treats {v} (Disease) germ cell cancer
Dactinomycin {u} (Compound) binds {v} (Gene) ABCB1
Dactinomycin {u} (Compound) upregulates {v} (Gene) PRR15L
Dactinomycin {u} (Compound) downregulates {v} (Gene) RNPS1
Dactinomycin {u} (Compound) causes {v} (Side Effect) Discomfort
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rilonacept
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anakinra
Dactinomycin {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Dactinomycin (Compound) treats germ cell cancer (Disease)
Dactinomycin (Compound) binds ABCB1 (Gene)
Dactinomycin (Compound) upregulates PRR15L (Gene)
Dactinomycin (Compound) downregulates RNPS1 (Gene)
Dactinomycin (Compound) causes Discomfort (Side Effect)
Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Anakinra
Dactinomycin may lead to a major life threatening interaction when taken with Leflunomide