DDInter1791 DDInter576
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Theophylline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Theophylline {u} (Compound) binds {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Theophylline {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Theophylline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Theophylline {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Theophylline {u} (Compound) binds {v} (Gene) HDAC2
HDAC2 {u} (Gene) is regulated by {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Theophylline {u} (Compound) binds {v} (Gene) ADORA1
ADORA1 {u} (Gene) is downregulated by {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Theophylline {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propylthiouracil
Propylthiouracil {u} (Compound) binds {v} (Gene) DBH
DBH {u} (Gene) is bound by {v} (Compound) Disulfiram
Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Theophylline (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Disulfiram (Compound)
Theophylline (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Disulfiram (Compound)
Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Theophylline (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Theophylline (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is regulated by DNAJB2 (Gene) and DNAJB2 (Gene) is upregulated by Disulfiram (Compound)
Theophylline (Compound) binds ADORA1 (Gene) and ADORA1 (Gene) is downregulated by alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Theophylline (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Disulfiram (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil and Propylthiouracil (Compound) binds DBH (Gene) and DBH (Gene) is bound by Disulfiram (Compound)