DDInter241 DDInter105
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239]
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Bromfenac {u} (Compound) resembles {v} (Compound) Balsalazide
Bromfenac {u} (Compound) resembles {v} (Compound) Suprofen
Bromfenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Bromfenac {u} (Compound) binds {v} (Gene) PTGS2
Bromfenac {u} (Compound) upregulates {v} (Gene) DDX10
Bromfenac {u} (Compound) is included by {v} (Pharmacologic Class) Cyclooxygenase Inhibitors
Bromfenac {u} (Compound) downregulates {v} (Gene) IFRD2
Bromfenac {u} (Compound) causes {v} (Side Effect) Eye pain
Bromfenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Bromfenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Bromfenac (Compound) resembles Balsalazide (Compound)
Bromfenac (Compound) resembles Suprofen (Compound)
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Bromfenac (Compound) binds PTGS2 (Gene)
Bromfenac (Compound) upregulates DDX10 (Gene)
Bromfenac (Compound) is included by Cyclooxygenase Inhibitors (Pharmacologic Class)
Bromfenac (Compound) downregulates IFRD2 (Gene)
Bromfenac (Compound) causes Eye pain (Side Effect)
Bromfenac may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Bromfenac may cause a minor interaction that can limit clinical effects when taken with Linaclotide