DDInter1279 DDInter1676
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Neostigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Neostigmine {u} (Compound) resembles {v} (Compound) Demecarium
Neostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Edrophonium
Neostigmine {u} (Compound) binds {v} (Gene) BCHE
Neostigmine {u} (Compound) upregulates {v} (Gene) RPP38
Neostigmine {u} (Compound) downregulates {v} (Gene) CD320
Neostigmine {u} (Compound) causes {v} (Side Effect) Post procedural nausea
Neostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Neostigmine {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Neostigmine (Compound) resembles Pyridostigmine (Compound)
Neostigmine (Compound) resembles Demecarium (Compound)
Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium
Neostigmine (Compound) binds BCHE (Gene)
Neostigmine (Compound) upregulates RPP38 (Gene)
Neostigmine (Compound) downregulates CD320 (Gene)
Neostigmine (Compound) causes Post procedural nausea (Side Effect)
Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Neostigmine may lead to a major life threatening interaction when taken with Iohexol