DDInter350 DDInter1676
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
Chlorambucil {u} (Compound) binds {v} (Gene) SLCO1A2
Chlorambucil {u} (Compound) upregulates {v} (Gene) DDB2
Chlorambucil {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Chlorambucil {u} (Compound) downregulates {v} (Gene) CENPA
Chlorambucil {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Chlorambucil (Compound) resembles Melphalan (Compound)
Chlorambucil (Compound) treats ovarian cancer (Disease)
Chlorambucil (Compound) binds SLCO1A2 (Gene)
Chlorambucil (Compound) upregulates DDB2 (Gene)
Chlorambucil (Compound) is included by Alkylating Activity (Pharmacologic Class)
Chlorambucil (Compound) downregulates CENPA (Gene)
Chlorambucil (Compound) causes Hyperuricaemia (Side Effect)