DDInter458 DDInter1158
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease . Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent . Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules . In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TERF2IP
TERF2IP {u} (Gene) is downregulated by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Breast pain
Breast pain {u} (Side Effect) is caused by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Levodopa
Levodopa {u} (Compound) resembles {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is regulated by {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is downregulated by {v} (Compound) Methyldopa
Methyldopa {u} (Compound) resembles {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PIN1
PIN1 {u} (Gene) is regulated by {v} (Gene) NR3C1
NR3C1 {u} (Gene) is upregulated by {v} (Compound) Mesalazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TERF2IP
TERF2IP {u} (Gene) is regulated by {v} (Gene) SLC35F2
SLC35F2 {u} (Gene) is downregulated by {v} (Compound) Mesalazine
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Mesalazine (Compound)
Cyclosporine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Mesalazine (Compound)
Cyclosporine (Compound) upregulates TERF2IP (Gene) and TERF2IP (Gene) is downregulated by Mesalazine (Compound)
Cyclosporine (Compound) causes Breast pain (Side Effect) and Breast pain (Side Effect) is caused by Mesalazine (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Levodopa (Compound) and Levodopa (Compound) resembles Mesalazine (Compound)
Cyclosporine (Compound) upregulates KIAA0753 (Gene) and KIAA0753 (Gene) is regulated by KRT19 (Gene) and KRT19 (Gene) is upregulated by Mesalazine (Compound)
Cyclosporine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Mesalazine (Compound)
Cyclosporine (Compound) downregulates SPR (Gene) and SPR (Gene) is downregulated by Methyldopa (Compound) and Methyldopa (Compound) resembles Mesalazine (Compound)
Cyclosporine (Compound) downregulates PIN1 (Gene) and PIN1 (Gene) is regulated by NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Mesalazine (Compound)
Cyclosporine (Compound) upregulates TERF2IP (Gene) and TERF2IP (Gene) is regulated by SLC35F2 (Gene) and SLC35F2 (Gene) is downregulated by Mesalazine (Compound)