DDInter45 DDInter1960
A phenothiazine derivative that is used as an antipruritic.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Alimemazine {u} (Compound) resembles {v} (Compound) Acetophenazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orphenadrine
Alimemazine {u} (Compound) resembles {v} (Compound) Pheniramine
Alimemazine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Alimemazine {u} (Compound) binds {v} (Gene) CYP3A4
Alimemazine {u} (Compound) upregulates {v} (Gene) CHEK2
Alimemazine {u} (Compound) downregulates {v} (Gene) PDHX
Alimemazine {u} (Compound) causes {v} (Side Effect) Respiratory depression
Alimemazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Alimemazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Alimemazine (Compound) resembles Acetophenazine (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine
Alimemazine (Compound) resembles Pheniramine (Compound)
Alimemazine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Alimemazine (Compound) binds CYP3A4 (Gene)
Alimemazine (Compound) upregulates CHEK2 (Gene)
Alimemazine (Compound) downregulates PDHX (Gene)
Alimemazine (Compound) causes Respiratory depression (Side Effect)
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate