DDInter1123 DDInter553
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Digitoxin
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is associated with {v} (Gene) XPOT
XPOT {u} (Gene) is downregulated by {v} (Compound) Digitoxin
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Digoxin
Digoxin {u} (Compound) resembles {v} (Compound) Digitoxin
Mannitol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digitoxin
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is associated with {v} (Gene) NR3C1
NR3C1 {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Mannitol {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digitoxin
Mannitol {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Digoxin
Digoxin {u} (Compound) resembles {v} (Compound) Digitoxin
Mannitol {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is palliated by {v} (Compound) Epinephrine
Epinephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digitoxin
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Digitoxin (Compound)
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is associated with XPOT (Gene) and XPOT (Gene) is downregulated by Digitoxin (Compound)
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Digoxin (Compound) and Digoxin (Compound) resembles Digitoxin (Compound)
Mannitol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Paricalcitol (Compound) and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is associated with NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Digitoxin (Compound)
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates RELB (Gene) and RELB (Gene) is upregulated by Digitoxin (Compound)
Mannitol (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin
Mannitol (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Digoxin (Compound) and Digoxin (Compound) resembles Digitoxin (Compound)
Mannitol (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Epoprostenol (Compound) and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is palliated by Epinephrine (Compound) and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin