DDInter856 DDInter491
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries. In the USA it is was approved in March, 2016 as Defitelio.
Defibrotide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clove
Defibrotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diflunisal
Defibrotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levomilnacipran
Defibrotide {u} may lead to a major life threatening interaction when taken with {v} Ardeparin
Defibrotide {u} may lead to a major life threatening interaction when taken with {v} Fedratinib
Defibrotide may cause a minor interaction that can limit clinical effects when taken with Clove
Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran
Defibrotide may lead to a major life threatening interaction when taken with Ardeparin
Defibrotide may lead to a major life threatening interaction when taken with Fedratinib