DDInter44 DDInter1016
Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70. Alfuzosin is an alpha-1 adrenergic blocker used in the symptomatic treatment of BPH that works by relaxing the muscles in the prostate and bladder neck. It was initially approved by the FDA in 2003 and is marketed by several pharmaceutical companies.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Alfuzosin {u} (Compound) resembles {v} (Compound) Terazosin
Alfuzosin {u} (Compound) resembles {v} (Compound) Prazosin
Alfuzosin {u} (Compound) binds {v} (Gene) ADRA1A
Alfuzosin {u} (Compound) upregulates {v} (Gene) PAK1
Alfuzosin {u} (Compound) downregulates {v} (Gene) RBM34
Alfuzosin {u} (Compound) causes {v} (Side Effect) Coronary artery disease
Alfuzosin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Alfuzosin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabilone
Alfuzosin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Alfuzosin {u} may lead to a major life threatening interaction when taken with {v} Cobicistat
Alfuzosin (Compound) resembles Terazosin (Compound)
Alfuzosin (Compound) resembles Prazosin (Compound)
Alfuzosin (Compound) binds ADRA1A (Gene)
Alfuzosin (Compound) upregulates PAK1 (Gene)
Alfuzosin (Compound) downregulates RBM34 (Gene)
Alfuzosin (Compound) causes Coronary artery disease (Side Effect)
Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Nabilone
Alfuzosin may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Alfuzosin may lead to a major life threatening interaction when taken with Cobicistat