DDInter1729 DDInter1263
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Sulindac {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Naltrexone
Sulindac {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Oxycodone
Oxycodone {u} may lead to a major life threatening interaction when taken with {v} Naltrexone
Sulindac {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Butorphanol
Butorphanol {u} (Compound) resembles {v} (Compound) Naltrexone
Sulindac {u} (Compound) causes {v} (Side Effect) Colitis
Colitis {u} (Side Effect) is caused by {v} (Compound) Fenofibrate
Fenofibrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Sulindac {u} (Compound) causes {v} (Side Effect) Purpura
Purpura {u} (Side Effect) is caused by {v} (Compound) Acitretin
Acitretin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Sulindac {u} (Compound) causes {v} (Side Effect) Conjunctivitis
Conjunctivitis {u} (Side Effect) is caused by {v} (Compound) Buprenorphine
Buprenorphine {u} (Compound) resembles {v} (Compound) Naltrexone
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Tizanidine
Tizanidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Buprenorphine
Buprenorphine {u} (Compound) resembles {v} (Compound) Naltrexone
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) regulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Naltrexone
Sulindac {u} (Compound) binds {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) is regulated by {v} (Gene) FOXO3
FOXO3 {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Sulindac (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Naltrexone (Compound)
Sulindac (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Oxycodone (Compound) and Oxycodone may lead to a major life threatening interaction when taken with Naltrexone
Sulindac (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Butorphanol (Compound) and Butorphanol (Compound) resembles Naltrexone (Compound)
Sulindac (Compound) causes Colitis (Side Effect) and Colitis (Side Effect) is caused by Fenofibrate (Compound) and Fenofibrate may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Sulindac (Compound) causes Purpura (Side Effect) and Purpura (Side Effect) is caused by Acitretin (Compound) and Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Sulindac (Compound) causes Conjunctivitis (Side Effect) and Conjunctivitis (Side Effect) is caused by Buprenorphine (Compound) and Buprenorphine (Compound) resembles Naltrexone (Compound)
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Tizanidine (Compound) and Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Buprenorphine (Compound) and Buprenorphine (Compound) resembles Naltrexone (Compound)
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) regulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Naltrexone (Compound)
Sulindac (Compound) binds AKR1B1 (Gene) and AKR1B1 (Gene) is regulated by FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Naltrexone (Compound)