DDInter907 DDInter1376
Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Iloperidone {u} (Compound) resembles {v} (Compound) Gefitinib
Iloperidone {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Iloperidone {u} (Compound) resembles {v} (Compound) Paliperidone
Iloperidone {u} (Compound) binds {v} (Gene) DRD1
Iloperidone {u} (Compound) upregulates {v} (Gene) PAK6
Iloperidone {u} (Compound) downregulates {v} (Gene) DKK3
Iloperidone {u} (Compound) causes {v} (Side Effect) Menstruation irregular
Iloperidone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Iloperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rolapitant
Iloperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Iloperidone (Compound) resembles Gefitinib (Compound)
Iloperidone may lead to a major life threatening interaction when taken with Cisapride
Iloperidone (Compound) resembles Paliperidone (Compound)
Iloperidone (Compound) binds DRD1 (Gene)
Iloperidone (Compound) upregulates PAK6 (Gene)
Iloperidone (Compound) downregulates DKK3 (Gene)
Iloperidone (Compound) causes Menstruation irregular (Side Effect)
Iloperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Clidinium