DDInter268 DDInter553
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Digitoxin
Calcitriol {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Calcitriol {u} (Compound) downregulates {v} (Gene) IER3
IER3 {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Calcitriol {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Digitoxin
Calcitriol {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is downregulated by {v} (Compound) Digitoxin
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digitoxin
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Digoxin
Digoxin {u} (Compound) resembles {v} (Compound) Digitoxin
Calcitriol {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Digoxin {u} (Compound) resembles {v} (Compound) Digitoxin
Calcitriol {u} (Compound) downregulates {v} (Gene) IER3
IER3 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Digoxin {u} (Compound) resembles {v} (Compound) Digitoxin
Calcitriol {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Digoxin
Digoxin {u} (Compound) resembles {v} (Compound) Digitoxin
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digitoxin (Compound)
Calcitriol (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Digitoxin (Compound)
Calcitriol (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Digitoxin (Compound)
Calcitriol (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Digitoxin (Compound)
Calcitriol (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is downregulated by Digitoxin (Compound)
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digoxin (Compound) and Digoxin (Compound) resembles Digitoxin (Compound)
Calcitriol (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Digoxin (Compound) and Digoxin (Compound) resembles Digitoxin (Compound)
Calcitriol (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Digoxin (Compound) and Digoxin (Compound) resembles Digitoxin (Compound)
Calcitriol (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Digoxin (Compound) and Digoxin (Compound) resembles Digitoxin (Compound)