DDInter150 DDInter904
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is regulated by {v} (Gene) PSMB9
PSMB9 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) is regulated by {v} (Gene) SOX2
SOX2 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Idarubicin
Azathioprine {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Idarubicin (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) is upregulated by Idarubicin (Compound)
Azathioprine (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is downregulated by Idarubicin (Compound)
Azathioprine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound)
Azathioprine (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is regulated by PSMB9 (Gene) and PSMB9 (Gene) is upregulated by Idarubicin (Compound)
Azathioprine (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is regulated by SOX2 (Gene) and SOX2 (Gene) is upregulated by Idarubicin (Compound)
Azathioprine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ABCC1 (Gene) and ABCC1 (Gene) is bound by Idarubicin (Compound)
Azathioprine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)