DDInter573 DDInter596
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Dipyridamole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) PDE6D
PDE6D {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) PDE6D
PDE6D {u} (Gene) is upregulated by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) PDE8A
PDE8A {u} (Gene) is downregulated by {v} (Disease) lung cancer
lung cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is associated with {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) PDE3B
PDE3B {u} (Gene) covaries with {v} (Gene) STIL
STIL {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dipyridamole {u} (Compound) binds {v} (Gene) ADA
ADA {u} (Gene) regulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dipyridamole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxorubicin (Compound)
Dipyridamole (Compound) binds PDE6D (Gene) and PDE6D (Gene) is upregulated by Doxorubicin (Compound)
Dipyridamole (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Doxorubicin (Compound)
Dipyridamole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Dipyridamole (Compound) binds PDE6D (Gene) and PDE6D (Gene) is upregulated by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Dipyridamole (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Dipyridamole (Compound) binds PDE8A (Gene) and PDE8A (Gene) is downregulated by lung cancer (Disease) and lung cancer (Disease) is treated by Doxorubicin (Compound)
Dipyridamole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is associated with ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Doxorubicin (Compound)
Dipyridamole (Compound) binds PDE3B (Gene) and PDE3B (Gene) covaries with STIL (Gene) and STIL (Gene) is downregulated by Doxorubicin (Compound)
Dipyridamole (Compound) binds ADA (Gene) and ADA (Gene) regulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Doxorubicin (Compound)