DDInter1300 DDInter1435
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nitisinone {u} (Compound) binds {v} (Gene) HPD
Nitisinone {u} (Compound) is included by {v} (Pharmacologic Class) Hydroxyphenylpyruvate Dioxygenase Inhibitors
Nitisinone {u} (Compound) causes {v} (Side Effect) Rash erythematous
Nitisinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Netupitant
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Butalbital
Nitisinone (Compound) resembles Flutamide (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound)
Nitisinone (Compound) binds HPD (Gene)
Nitisinone (Compound) is included by Hydroxyphenylpyruvate Dioxygenase Inhibitors (Pharmacologic Class)
Nitisinone (Compound) causes Rash erythematous (Side Effect)
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Netupitant
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Butalbital