DDInter1355 DDInter255
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Oxaliplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) ATP7B
ATP7B {u} (Gene) is regulated by {v} (Gene) NFATC3
NFATC3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) TP53BP2
TP53BP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) CYP1B1
CYP1B1 {u} (Gene) is regulated by {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) SOD1
SOD1 {u} (Gene) interacts with {v} (Gene) HDAC6
HDAC6 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Oxaliplatin {u} (Compound) binds {v} (Gene) SLC22A3
SLC22A3 {u} (Gene) interacts with {v} (Gene) ABL1
ABL1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Oxaliplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Sulfamethoxazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Oxaliplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Oxaliplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Oxaliplatin (Compound) binds ATP7B (Gene) and ATP7B (Gene) is regulated by NFATC3 (Gene) and NFATC3 (Gene) is upregulated by Busulfan (Compound)
Oxaliplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates TP53BP2 (Gene) and TP53BP2 (Gene) is upregulated by Busulfan (Compound)
Oxaliplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Busulfan (Compound)
Oxaliplatin (Compound) binds MPO (Gene) and MPO (Gene) is downregulated by hematologic cancer (Disease) and MPO (Disease) associated with hematologic cancer (Gene) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Oxaliplatin (Compound) binds CYP1B1 (Gene) and CYP1B1 (Gene) is regulated by ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Busulfan (Compound)
Oxaliplatin (Compound) binds SOD1 (Gene) and SOD1 (Gene) interacts with HDAC6 (Gene) and HDAC6 (Gene) is downregulated by Busulfan (Compound)
Oxaliplatin (Compound) binds SLC22A3 (Gene) and SLC22A3 (Gene) interacts with ABL1 (Gene) and ABL1 (Gene) is upregulated by Busulfan (Compound)
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)