DDInter1834 DDInter1533
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Topiramate {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Promethazine
Topiramate {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Topiramate {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Promethazine
Topiramate {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Topiramate {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Phentermine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Topiramate {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Aluminum hydroxide
Aluminum hydroxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Promethazine
Topiramate {u} (Compound) causes {v} (Side Effect) Asthma
Asthma {u} (Side Effect) is caused by {v} (Compound) Propericiazine
Propericiazine {u} (Compound) resembles {v} (Compound) Promethazine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Levetiracetam
Levetiracetam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Topiramate {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Sucralfate
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Promethazine
Topiramate {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is associated with {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Promethazine
Topiramate (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Promethazine (Compound)
Topiramate (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Topiramate (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Diltiazem (Compound) and Diltiazem (Compound) resembles Promethazine (Compound)
Topiramate (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Topiramate (Compound) treats obesity (Disease) and obesity (Disease) is treated by Phentermine (Compound) and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Topiramate (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Aluminum hydroxide (Compound) and Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Promethazine
Topiramate (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Propericiazine (Compound) and Propericiazine (Compound) resembles Promethazine (Compound)
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Levetiracetam (Compound) and Levetiracetam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Topiramate (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Sucralfate (Compound) and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Promethazine
Topiramate (Compound) treats obesity (Disease) and obesity (Disease) is associated with HTR2A (Gene) and HTR2A (Gene) is bound by Promethazine (Compound)