DDInter405 DDInter1956
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) resembles {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) causes {v} (Side Effect) Colitis
Colitis {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Clofarabine {u} (Compound) resembles {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Zalcitabine (Compound)
Clofarabine (Compound) resembles Cytarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Clofarabine (Compound) resembles Decitabine (Compound) and Decitabine (Compound) resembles Zalcitabine (Compound)
Clofarabine (Compound) binds DCK (Gene) and DCK (Gene) is bound by Zalcitabine (Compound)
Clofarabine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Zalcitabine (Compound)
Clofarabine (Compound) causes Colitis (Side Effect) and Colitis (Side Effect) is caused by Zalcitabine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Clofarabine (Compound) resembles Cytarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Clofarabine (Compound) resembles Decitabine (Compound) and Decitabine (Compound) resembles Emtricitabine (Compound) and Emtricitabine (Compound) resembles Zalcitabine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)