DDInter1853 DDInter1313
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Tretinoin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) ST7
ST7 {u} (Gene) is upregulated by {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) PRR7
PRR7 {u} (Gene) is downregulated by {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) ST7
ST7 {u} (Gene) is upregulated by {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP2A6
CYP2A6 {u} (Gene) is bound by {v} (Compound) Cyclophosphamide
Cyclophosphamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) ST7
ST7 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) PRR7
PRR7 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norfloxacin
Tretinoin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Norfloxacin (Compound)
Tretinoin (Compound) downregulates ST7 (Gene) and ST7 (Gene) is upregulated by Norfloxacin (Compound)
Tretinoin (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Norfloxacin (Compound)
Tretinoin (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Norfloxacin (Compound)
Tretinoin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates ST7 (Gene) and ST7 (Gene) is upregulated by Norfloxacin (Compound)
Tretinoin (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Norfloxacin (Compound)
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Norfloxacin (Compound)
Tretinoin (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Cyclophosphamide (Compound) and Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Norfloxacin
Tretinoin (Compound) downregulates ST7 (Gene) and ST7 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Norfloxacin (Compound)
Tretinoin (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin