DDInter1938 DDInter431
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
Vincristine {u} (Compound) binds {v} (Gene) SLC22A3
SLC22A3 {u} (Gene) is bound by {v} (Compound) Colchicine
Vincristine {u} (Compound) downregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is upregulated by {v} (Compound) Colchicine
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Vincristine {u} (Compound) upregulates {v} (Gene) MICAL1
MICAL1 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Vincristine {u} (Compound) binds {v} (Gene) TUBA4A
TUBA4A {u} (Gene) is upregulated by {v} (Compound) Colchicine
Vincristine {u} (Compound) downregulates {v} (Gene) AKR7A2
AKR7A2 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Vincristine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Colchicine
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Vincristine {u} (Compound) binds {v} (Gene) SLC22A3
SLC22A3 {u} (Gene) is bound by {v} (Compound) Oxaliplatin
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Vincristine (Compound) binds SLC22A3 (Gene) and SLC22A3 (Gene) is bound by Colchicine (Compound)
Vincristine (Compound) downregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Colchicine (Compound)
Vincristine (Compound) binds TUBB6 (Gene) and Vincristine (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is upregulated by Colchicine (Compound)
Vincristine (Compound) upregulates MICAL1 (Gene) and MICAL1 (Gene) is upregulated by Colchicine (Compound)
Vincristine (Compound) binds TUBA4A (Gene) and TUBA4A (Gene) is upregulated by Colchicine (Compound)
Vincristine (Compound) downregulates AKR7A2 (Gene) and AKR7A2 (Gene) is downregulated by Colchicine (Compound)
Vincristine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Colchicine (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Vincristine (Compound) binds SLC22A3 (Gene) and SLC22A3 (Gene) is bound by Oxaliplatin (Compound) and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Colchicine