DDInter364 DDInter129
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, deb
Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications. The U.S. Food and Drug Administration (FDA) approved atazanavir on June 20, 2003.
Chlorpropamide {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Atazanavir
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Atazanavir
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atazanavir
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atazanavir
Chlorpropamide {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Abiraterone
Abiraterone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atazanavir
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Eruption
Eruption {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Terbinafine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atazanavir
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Saquinavir
Saquinavir {u} (Compound) resembles {v} (Compound) Atazanavir
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Saquinavir
Saquinavir {u} (Compound) resembles {v} (Compound) Atazanavir
Chlorpropamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atazanavir (Compound)
Chlorpropamide (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Atazanavir (Compound)
Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir
Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir
Chlorpropamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ritonavir (Compound) and Ritonavir (Compound) resembles Atazanavir (Compound)
Chlorpropamide (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Abiraterone (Compound) and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Atazanavir
Chlorpropamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Ritonavir (Compound) and Ritonavir (Compound) resembles Atazanavir (Compound)
Chlorpropamide (Compound) causes Eruption (Side Effect) and Eruption (Side Effect) is caused by Terbinafine (Compound) and Terbinafine may cause a minor interaction that can limit clinical effects when taken with Atazanavir
Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)