DDInter263 DDInter178
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans. Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection. The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999. According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Caffeine {u} (Compound) resembles {v} (Compound) Oxtriphylline
Caffeine {u} (Compound) resembles {v} (Compound) Dyphylline
Caffeine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Caffeine {u} (Compound) binds {v} (Gene) CYP1A2
Caffeine {u} (Compound) upregulates {v} (Gene) HOXC6
Caffeine {u} (Compound) palliates {v} (Disease) migraine
Caffeine {u} (Compound) is included by {v} (Pharmacologic Class) Central Nervous System Stimulation
Caffeine {u} (Compound) downregulates {v} (Gene) DNAJA3
Caffeine {u} (Compound) causes {v} (Side Effect) Necrotising colitis
Caffeine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nicotine
Caffeine (Compound) resembles Oxtriphylline (Compound)
Caffeine (Compound) resembles Dyphylline (Compound)
Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline
Caffeine (Compound) binds CYP1A2 (Gene)
Caffeine (Compound) upregulates HOXC6 (Gene)
Caffeine (Compound) palliates migraine (Disease)
Caffeine (Compound) is included by Central Nervous System Stimulation (Pharmacologic Class)
Caffeine (Compound) downregulates DNAJA3 (Gene)
Caffeine (Compound) causes Necrotising colitis (Side Effect)
Caffeine may cause a minor interaction that can limit clinical effects when taken with Nicotine