DDInter336 DDInter1759
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Celecoxib {u} (Compound) causes {v} (Side Effect) Cerebrovascular disorder
Cerebrovascular disorder {u} (Side Effect) is caused by {v} (Compound) Telmisartan
Celecoxib {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Losartan
Losartan {u} (Compound) resembles {v} (Compound) Telmisartan
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Telmisartan
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Telmisartan
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Telmisartan
Celecoxib {u} (Compound) upregulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is regulated by {v} (Gene) PPARG
PPARG {u} (Gene) is bound by {v} (Compound) Telmisartan
Celecoxib {u} (Compound) palliates {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is associated with {v} (Gene) PPARG
PPARG {u} (Gene) is bound by {v} (Compound) Telmisartan
Celecoxib {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Telmisartan
Celecoxib (Compound) causes Cerebrovascular disorder (Side Effect) and Cerebrovascular disorder (Side Effect) is caused by Telmisartan (Compound)
Celecoxib (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Losartan (Compound) and Losartan (Compound) resembles Telmisartan (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Telmisartan (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Telmisartan (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telmisartan (Compound)
Celecoxib (Compound) upregulates ERAP2 (Gene) and ERAP2 (Gene) is regulated by PPARG (Gene) and PPARG (Gene) is bound by Telmisartan (Compound)
Celecoxib (Compound) palliates systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is associated with PPARG (Gene) and PPARG (Gene) is bound by Telmisartan (Compound)
Celecoxib (Compound) palliates colon cancer (Disease) and colon cancer (Disease) downregulates ABCG2 (Gene) and ABCG2 (Gene) is bound by Telmisartan (Compound)