DDInter576 DDInter1552
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors and low affinity for other receptors.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Quazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diazepam
Diazepam {u} (Compound) resembles {v} (Compound) Quazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Diazepam
Diazepam {u} (Compound) resembles {v} (Compound) Quazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Triazolam
Triazolam {u} (Compound) resembles {v} (Compound) Quazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Triazolam
Triazolam {u} (Compound) resembles {v} (Compound) Quazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Numbness
Numbness {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Theophylline
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Numbness
Numbness {u} (Side Effect) is caused by {v} (Compound) Nabilone
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quazepam (Compound)
Disulfiram (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Quazepam (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diazepam (Compound) and Diazepam (Compound) resembles Quazepam (Compound)
Disulfiram (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Diazepam (Compound) and Diazepam (Compound) resembles Quazepam (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Triazolam (Compound) and Triazolam (Compound) resembles Quazepam (Compound)
Disulfiram (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Triazolam (Compound) and Triazolam (Compound) resembles Quazepam (Compound)
Disulfiram (Compound) causes Numbness (Side Effect) and Numbness (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Quazepam
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Quazepam
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Theophylline (Compound) and Theophylline may cause a minor interaction that can limit clinical effects when taken with Quazepam
Disulfiram (Compound) causes Numbness (Side Effect) and Numbness (Side Effect) is caused by Nabilone (Compound) and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Quazepam