DDInter1902 DDInter1376
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Uracil mustard {u} (Compound) resembles {v} (Compound) Fluorouracil
Uracil mustard {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Uracil mustard {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sipuleucel-T
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ceftazidime
Uracil mustard {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Uracil mustard {u} may lead to a major life threatening interaction when taken with {v} Golimumab
Uracil mustard (Compound) resembles Fluorouracil (Compound)
Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime
Uracil mustard may lead to a major life threatening interaction when taken with Clozapine
Uracil mustard may lead to a major life threatening interaction when taken with Golimumab