DDInter1918 DDInter1016
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum. PDE5 inhibitors, such as vardenafil, inhibit the degradation of cGMP and allow increased blood flow into the penis, resulting in an erection.[A258303,L45563,L45568]. Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil. The FDA approved the use of v
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Udenafil
Vardenafil {u} (Compound) binds {v} (Gene) CYP3A4
Vardenafil {u} (Compound) upregulates {v} (Gene) ABCC5
Vardenafil {u} (Compound) downregulates {v} (Gene) RNH1
Vardenafil {u} (Compound) causes {v} (Side Effect) Amnesia
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palonosetron
Vardenafil {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Vardenafil {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Vardenafil (Compound) resembles Sildenafil (Compound)
Vardenafil (Compound) resembles Udenafil (Compound)
Vardenafil (Compound) binds CYP3A4 (Gene)
Vardenafil (Compound) upregulates ABCC5 (Gene)
Vardenafil (Compound) downregulates RNH1 (Gene)
Vardenafil (Compound) causes Amnesia (Side Effect)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron
Vardenafil may lead to a major life threatening interaction when taken with Hydroxychloroquine
Vardenafil may lead to a major life threatening interaction when taken with Cisapride