DDInter458 DDInter68
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Amiloride
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiloride
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amiloride
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tinnitus
Tinnitus {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiloride
Cyclosporine {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Amoxicillin
Amoxicillin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amiloride
Cyclosporine {u} (Compound) treats {v} (Disease) focal segmental glomerulosclerosis
focal segmental glomerulosclerosis {u} (Disease) resembles {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Amiloride
Cyclosporine {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Amiloride
Cyclosporine {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is regulated by {v} (Gene) SCNN1A
SCNN1A {u} (Gene) is bound by {v} (Compound) Amiloride
Cyclosporine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Amiloride
Cyclosporine {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Metformin
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiloride
Cyclosporine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Amiloride (Compound)
Cyclosporine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Amiloride
Cyclosporine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Amiloride
Cyclosporine (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Bupropion (Compound) and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Amiloride
Cyclosporine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Amoxicillin (Compound) and Amoxicillin may cause a minor interaction that can limit clinical effects when taken with Amiloride
Cyclosporine (Compound) treats focal segmental glomerulosclerosis (Disease) and focal segmental glomerulosclerosis (Disease) resembles hypertension (Disease) and hypertension (Disease) is treated by Amiloride (Compound)
Cyclosporine (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Amiloride (Compound)
Cyclosporine (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is regulated by SCNN1A (Gene) and SCNN1A (Gene) is bound by Amiloride (Compound)
Cyclosporine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Amiloride (Compound)
Cyclosporine (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Metformin (Compound) and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Amiloride