DDInter507 DDInter856
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH. It has been employed clinically since 1972
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Desmopressin {u} (Compound) resembles {v} (Compound) Terlipressin
Desmopressin {u} (Compound) resembles {v} (Compound) Gonadorelin
Desmopressin {u} (Compound) binds {v} (Gene) AVPR2
Desmopressin {u} (Compound) is included by {v} (Pharmacologic Class) Vasopressins
Desmopressin {u} (Compound) causes {v} (Side Effect) Oropharyngeal discomfort
Desmopressin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetylsalicylic acid
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Desmopressin {u} may lead to a major life threatening interaction when taken with {v} Deflazacort
Desmopressin (Compound) resembles Terlipressin (Compound)
Desmopressin (Compound) resembles Gonadorelin (Compound)
Desmopressin (Compound) binds AVPR2 (Gene)
Desmopressin (Compound) is included by Vasopressins (Pharmacologic Class)
Desmopressin (Compound) causes Oropharyngeal discomfort (Side Effect)
Desmopressin may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline
Desmopressin may lead to a major life threatening interaction when taken with Deflazacort