DDInter1643 DDInter1147
Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe rheumatoid arthritis (RA) in combination with methotrexate. RA is a chronic inflammatory disease characterized by polyarthritis, and its treatment has been challenged by the different responses in every patient. Subcutaneous administration of sarilumab has been shown to decrease acute-phase reactant levels and improve clinical RA symptoms.
Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup C. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup C.
Sarilumab {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Sarilumab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Sarilumab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diroximel fumarate
Sarilumab {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Sarilumab {u} may lead to a major life threatening interaction when taken with {v} Smallpox (Vaccinia) Vaccine, Live
Sarilumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Sarilumab may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Sarilumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Sarilumab may lead to a major life threatening interaction when taken with Cladribine
Sarilumab may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live