DDInter475 DDInter1305
A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitroglycerin
Nitroglycerin {u} (Compound) binds {v} (Gene) GUCY1A2
GUCY1A2 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvoxamine
Fluvoxamine {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Clozapine {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} (Compound) upregulates {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Modafinil {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Nitroglycerin and Nitroglycerin (Compound) binds GUCY1A2 (Gene) and GUCY1A2 (Gene) is bound by Nitroprusside (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)
Dapsone may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate (Compound) upregulates CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)
Dapsone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)
Dapsone (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)
Dapsone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nitroprusside (Compound)