DDInter826 DDInter1662
Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guidelines by Diabetes Canada, sulfonylurea drugs are considered a second-line glucose-lowering therapy following metformin. Because sulfonylureas require functional pancreatic beta cells for their therapeutic effectiveness, sulfonylureas are more commonly used for early-stage type 2 diabetes when there is no progressed pancreatic failure. Compared to the first-generation sulfonylureas, such as [tolbutamide] and [chlorpropamide], second-generation sulfonylureas contain a more non-polar side chain in their chemical structure, which enhances their hypoglycemic potency. Compared to other members of the sulfonyl
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Glipizide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Glipizide {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Sertraline
Glipizide {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Glipizide {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Sertraline
Glipizide {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) regulates {v} (Gene) ELOVL6
ELOVL6 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Glipizide {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is regulated by {v} (Gene) NSDHL
NSDHL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Glipizide {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Glipizide {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Glipizide {u} (Compound) resembles {v} (Compound) Glyburide
Glyburide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Sertraline
Glipizide {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Glipizide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Glipizide (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Sertraline (Compound)
Glipizide (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sertraline (Compound)
Glipizide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Sertraline (Compound)
Glipizide (Compound) downregulates GRN (Gene) and GRN (Gene) regulates ELOVL6 (Gene) and ELOVL6 (Gene) is upregulated by Sertraline (Compound)
Glipizide (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is regulated by NSDHL (Gene) and NSDHL (Gene) is upregulated by Sertraline (Compound)
Glipizide (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Glipizide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Glipizide (Compound) resembles Glyburide (Compound) and Glyburide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Sertraline (Compound)
Glipizide (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)