DDInter458 DDInter1323
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is a life-threatening disease requiring life-long management. Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural hormone, somatostatin, which inhibits the secretion of growth hormone. Additionally, it is used for the treatment of acromegaly and symptoms arising from various tumors, including carcinoid tumors and vasoactive intestinal tumors (VIPomas). In the past, octreotide has been administered solely by injection. On June 26, 2020, the first approved delayed-release oral somatostatin analog, Mycapssa, received FDA approval for the long term maintenance treatment of acromegaly. This drug was developed by Chiasma Inc.[L14495,L14507,L14528]
Cyclosporine {u} (Compound) causes {v} (Side Effect) Arthropathy
Arthropathy {u} (Side Effect) is caused by {v} (Compound) Octreotide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Arthropathy
Arthropathy {u} (Side Effect) is caused by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Octreotide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Desmopressin
Desmopressin {u} (Compound) resembles {v} (Compound) Octreotide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Acne
Acne {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Octreotide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Octreotide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Octreotide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TES
TES {u} (Gene) is downregulated by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Octreotide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is downregulated by {v} (Compound) Nicardipine
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Octreotide
Cyclosporine {u} (Compound) downregulates {v} (Gene) AKT1
AKT1 {u} (Gene) is associated with {v} (Disease) thymus cancer
thymus cancer {u} (Disease) is treated by {v} (Compound) Octreotide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Nisoldipine
Nisoldipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Octreotide
Cyclosporine (Compound) causes Arthropathy (Side Effect) and Arthropathy (Side Effect) is caused by Octreotide (Compound)
Cyclosporine (Compound) causes Arthropathy (Side Effect) and Arthropathy (Side Effect) is caused by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Octreotide
Cyclosporine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Desmopressin (Compound) and Desmopressin (Compound) resembles Octreotide (Compound)
Cyclosporine (Compound) causes Acne (Side Effect) and Acne (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Octreotide
Cyclosporine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Bacitracin (Compound) and Bacitracin (Compound) resembles Octreotide (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Bacitracin (Compound) and Bacitracin (Compound) resembles Octreotide (Compound)
Cyclosporine (Compound) upregulates TES (Gene) and TES (Gene) is downregulated by Bacitracin (Compound) and Bacitracin (Compound) resembles Octreotide (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is downregulated by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Octreotide
Cyclosporine (Compound) downregulates AKT1 (Gene) and AKT1 (Gene) is associated with thymus cancer (Disease) and thymus cancer (Disease) is treated by Octreotide (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Octreotide