DDInter1008 DDInter513
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Ketoconazole {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) upregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) causes {v} (Side Effect) Papilloedema
Papilloedema {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) resembles {v} (Compound) Posaconazole
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Ketoconazole {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is associated with {v} (Disease) brain cancer
brain cancer {u} (Disease) is palliated by {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2A6
CYP2A6 {u} (Gene) is bound by {v} (Compound) Prednisolone
Prednisolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Ketoconazole {u} (Compound) binds {v} (Gene) CYP11A1
CYP11A1 {u} (Gene) interacts with {v} (Gene) SMAD3
SMAD3 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Ketoconazole (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Dexamethasone (Compound)
Ketoconazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Dexamethasone (Compound)
Ketoconazole (Compound) upregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Dexamethasone (Compound)
Ketoconazole (Compound) causes Papilloedema (Side Effect) and Papilloedema (Side Effect) is caused by Dexamethasone (Compound)
Ketoconazole (Compound) resembles Posaconazole (Compound) and Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone
Ketoconazole (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Dexamethasone (Compound)
Ketoconazole (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Paclitaxel (Compound) and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is associated with brain cancer (Disease) and brain cancer (Disease) is palliated by Dexamethasone (Compound)
Ketoconazole (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Prednisolone (Compound) and Prednisolone (Compound) resembles Dexamethasone (Compound)
Ketoconazole (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) interacts with SMAD3 (Gene) and SMAD3 (Gene) is downregulated by Dexamethasone (Compound)