DDInter906 DDInter1376
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Ifosfamide {u} (Compound) treats {v} (Disease) testicular cancer
Ifosfamide {u} (Compound) binds {v} (Gene) CYP2A6
Ifosfamide {u} (Compound) upregulates {v} (Gene) UBQLN2
Ifosfamide {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Ifosfamide {u} (Compound) downregulates {v} (Gene) STUB1
Ifosfamide {u} (Compound) causes {v} (Side Effect) Palpitations
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Ifosfamide (Compound) treats testicular cancer (Disease)
Ifosfamide (Compound) binds CYP2A6 (Gene)
Ifosfamide (Compound) upregulates UBQLN2 (Gene)
Ifosfamide (Compound) is included by Alkylating Activity (Pharmacologic Class)
Ifosfamide (Compound) downregulates STUB1 (Gene)
Ifosfamide (Compound) causes Palpitations (Side Effect)
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Quazepam