DDInter1707 DDInter832
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Spironolactone {u} (Compound) resembles {v} (Compound) Dydrogesterone
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Spironolactone {u} (Compound) treats {v} (Disease) dilated cardiomyopathy
Spironolactone {u} (Compound) binds {v} (Gene) PGR
Spironolactone {u} (Compound) upregulates {v} (Gene) WIF1
Spironolactone {u} (Compound) is included by {v} (Pharmacologic Class) Aldosterone Antagonists
Spironolactone {u} (Compound) downregulates {v} (Gene) GNAS
Spironolactone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Spironolactone (Compound) resembles Testosterone (Compound)
Spironolactone (Compound) resembles Dydrogesterone (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Spironolactone (Compound) treats dilated cardiomyopathy (Disease)
Spironolactone (Compound) binds PGR (Gene)
Spironolactone (Compound) upregulates WIF1 (Gene)
Spironolactone (Compound) is included by Aldosterone Antagonists (Pharmacologic Class)
Spironolactone (Compound) downregulates GNAS (Gene)
Spironolactone (Compound) causes Feeling abnormal (Side Effect)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin