DDInter1311 DDInter1665
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Norepinephrine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Sibutramine
Norepinephrine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Norepinephrine {u} (Compound) resembles {v} (Compound) Dopamine
Dopamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Norepinephrine {u} (Compound) resembles {v} (Compound) Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Norepinephrine {u} (Compound) resembles {v} (Compound) Levonordefrin
Levonordefrin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Norepinephrine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Atomoxetine
Atomoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Norepinephrine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Verapamil
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Norepinephrine {u} (Compound) causes {v} (Side Effect) Blood pressure increased
Blood pressure increased {u} (Side Effect) is caused by {v} (Compound) Fosaprepitant
Fosaprepitant {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Norepinephrine {u} (Compound) resembles {v} (Compound) Dopamine
Dopamine {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is bound by {v} (Compound) Sibutramine
Norepinephrine {u} (Compound) resembles {v} (Compound) Salbutamol
Salbutamol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sibutramine
Norepinephrine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Sibutramine (Compound)
Norepinephrine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Sibutramine (Compound)
Norepinephrine (Compound) resembles Dopamine (Compound) and Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Norepinephrine (Compound) resembles Salbutamol (Compound) and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Norepinephrine (Compound) resembles Levonordefrin (Compound) and Levonordefrin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Norepinephrine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Atomoxetine (Compound) and Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Norepinephrine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Verapamil (Compound) and Verapamil may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Norepinephrine (Compound) causes Blood pressure increased (Side Effect) and Blood pressure increased (Side Effect) is caused by Fosaprepitant (Compound) and Fosaprepitant may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Norepinephrine (Compound) resembles Dopamine (Compound) and Dopamine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Sibutramine (Compound)
Norepinephrine (Compound) resembles Salbutamol (Compound) and Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)