DDInter1055 DDInter893
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of [quinacrine] with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.** Hydroxychloroquine was granted FDA approval on 18 April 1955. A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.
Levofloxacin {u} (Compound) downregulates {v} (Gene) TES
TES {u} (Gene) is downregulated by {v} (Compound) Hydroxychloroquine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Ofloxacin {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Levofloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Levofloxacin {u} (Compound) downregulates {v} (Gene) TES
TES {u} (Gene) is upregulated by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Chloroquine
Chloroquine {u} (Compound) resembles {v} (Compound) Hydroxychloroquine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxychloroquine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Nystagmus
Nystagmus {u} (Side Effect) is caused by {v} (Compound) Primidone
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Primaquine
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Central nervous system disorder
Central nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Fesoterodine
Fesoterodine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Levofloxacin (Compound) downregulates TES (Gene) and TES (Gene) is downregulated by Hydroxychloroquine (Compound)
Levofloxacin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Levofloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may lead to a major life threatening interaction when taken with Hydroxychloroquine
Levofloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may lead to a major life threatening interaction when taken with Hydroxychloroquine
Levofloxacin (Compound) downregulates TES (Gene) and TES (Gene) is upregulated by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine
Levofloxacin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Chloroquine (Compound) and Chloroquine (Compound) resembles Hydroxychloroquine (Compound)
Levofloxacin (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine
Levofloxacin (Compound) causes Nystagmus (Side Effect) and Nystagmus (Side Effect) is caused by Primidone (Compound) and Primidone may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine
Levofloxacin (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Primaquine (Compound) and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Levofloxacin (Compound) causes Central nervous system disorder (Side Effect) and Central nervous system disorder (Side Effect) is caused by Fesoterodine (Compound) and Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine