DDInter1055 DDInter513
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) upregulates {v} (Gene) SELL
SELL {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) downregulates {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Ofloxacin {u} may lead to a major life threatening interaction when taken with {v} Dexamethasone
Levofloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} may lead to a major life threatening interaction when taken with {v} Dexamethasone
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) upregulates {v} (Gene) SELL
SELL {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Dexamethasone
Levofloxacin {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Fluorometholone
Fluorometholone {u} (Compound) resembles {v} (Compound) Dexamethasone
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dexamethasone (Compound)
Levofloxacin (Compound) upregulates SELL (Gene) and SELL (Gene) is upregulated by Dexamethasone (Compound)
Levofloxacin (Compound) downregulates PRKACA (Gene) and PRKACA (Gene) is downregulated by Dexamethasone (Compound)
Levofloxacin (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dexamethasone (Compound)
Levofloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may lead to a major life threatening interaction when taken with Dexamethasone
Levofloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may lead to a major life threatening interaction when taken with Dexamethasone
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Levofloxacin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Dexamethasone (Compound)
Levofloxacin (Compound) upregulates SELL (Gene) and SELL (Gene) is upregulated by Betamethasone (Compound) and Betamethasone (Compound) resembles Dexamethasone (Compound)
Levofloxacin (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Fluorometholone (Compound) and Fluorometholone (Compound) resembles Dexamethasone (Compound)