DDInter1359 DDInter535
Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feature is advantageous as compared to other benzodiazepines, and is likely owing in part to oxazepam's relatively simple metabolism. It is an active metabolite of both [diazepam] and [temazepam] and undergoes very little biotransformation following absorption, making it unlikely to participate in pharmacokinetic interactions.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Oxazepam {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Oxazepam {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Diazepam {u} (Compound) causes {v} (Side Effect) Lymphadenopathy
Lymphadenopathy {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) resembles {v} (Compound) Nitrazepam
Nitrazepam {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) resembles {v} (Compound) Flurbiprofen
Flurbiprofen {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) resembles {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Oxazepam {u} (Compound) resembles {v} (Compound) Alprazolam
Alprazolam {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) regulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Oxazepam {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Oxazepam (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Oxazepam (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Oxazepam (Compound) resembles Clozapine (Compound) and Clozapine (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Diazoxide (Compound)
Oxazepam (Compound) resembles Diazepam (Compound) and Diazepam (Compound) causes Lymphadenopathy (Side Effect) and Lymphadenopathy (Side Effect) is caused by Diazoxide (Compound)
Oxazepam (Compound) resembles Nitrazepam (Compound) and Nitrazepam (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Diazoxide (Compound)
Oxazepam (Compound) resembles Flurbiprofen (Compound) and Flurbiprofen (Compound) upregulates AGL (Gene) and AGL (Gene) is upregulated by Diazoxide (Compound)
Oxazepam (Compound) resembles Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Oxazepam (Compound) resembles Alprazolam (Compound) and Alprazolam (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Diazoxide (Compound)
Oxazepam (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) regulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Diazoxide (Compound)
Oxazepam (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)