DDInter75 DDInter1174
An antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Aminosalicylic acid {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) downregulates {v} (Gene) ITGAE
ITGAE {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Methyldopa
Methyldopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} may lead to a major life threatening interaction when taken with {v} Methotrexate
Aminosalicylic acid {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is downregulated by {v} (Disease) psoriasis
psoriasis {u} (Disease) is treated by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) stomach cancer
stomach cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) downregulates {v} (Gene) ITGAE
ITGAE {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Aminosalicylic acid {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Raltitrexed
Raltitrexed {u} (Compound) resembles {v} (Compound) Methotrexate
Aminosalicylic acid (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Methotrexate (Compound)
Aminosalicylic acid (Compound) binds PTGS2 (Gene) and Aminosalicylic acid (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Methotrexate (Compound)
Aminosalicylic acid (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Methotrexate (Compound)
Aminosalicylic acid (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Aminosalicylic acid (Compound) resembles Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Aminosalicylic acid (Compound) resembles Diflunisal (Compound) and Diflunisal may lead to a major life threatening interaction when taken with Methotrexate
Aminosalicylic acid (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is downregulated by psoriasis (Disease) and psoriasis (Disease) is treated by Methotrexate (Compound)
Aminosalicylic acid (Compound) binds PTGS2 (Gene) and Aminosalicylic acid (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is associated with stomach cancer (Disease) and stomach cancer (Disease) is treated by Methotrexate (Compound)
Aminosalicylic acid (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Methotrexate (Compound)
Aminosalicylic acid (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Raltitrexed (Compound) and Raltitrexed (Compound) resembles Methotrexate (Compound)