DDInter1873 DDInter1397
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Cisapride
Cisapride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) downregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Verapamil
Verapamil {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) downregulates {v} (Gene) GRWD1
GRWD1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Trimetrexate
Trimetrexate {u} (Compound) causes {v} (Side Effect) Hyponatraemia
Hyponatraemia {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Trimethoprim
Trimethoprim {u} (Compound) binds {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) upregulates {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) interacts with {v} (Gene) HDAC5
HDAC5 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Cisapride
Cisapride {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Trimethobenzamide (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Papaverine (Compound) and Papaverine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Cisapride (Compound) and Cisapride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Papaverine (Compound) and Papaverine (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Verapamil (Compound) and Verapamil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Papaverine (Compound) and Papaverine (Compound) downregulates GRWD1 (Gene) and GRWD1 (Gene) is downregulated by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Trimetrexate (Compound) and Trimetrexate (Compound) causes Hyponatraemia (Side Effect) and Hyponatraemia (Side Effect) is caused by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Trimethoprim (Compound) and Trimethoprim (Compound) binds TYMS (Gene) and TYMS (Gene) is downregulated by Paroxetine (Compound)
Trimethobenzamide (Compound) upregulates HIST1H2BK (Gene) and HIST1H2BK (Gene) interacts with HDAC5 (Gene) and HDAC5 (Gene) is upregulated by Paroxetine (Compound)
Trimethobenzamide (Compound) resembles Cisapride (Compound) and Cisapride (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Paroxetine (Compound)