DDInter154 DDInter1430
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007. While the use of pergolide in humans is still approved in only some countries, pergolide is mainly used for veterinary purposes.
Azelastine {u} (Compound) binds {v} (Gene) ADRA1B
ADRA1B {u} (Gene) is bound by {v} (Compound) Pergolide
Azelastine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Pergolide
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pergolide
Azelastine {u} (Compound) binds {v} (Gene) ADRA1B
ADRA1B {u} (Gene) is bound by {v} (Compound) Cabergoline
Cabergoline {u} (Compound) resembles {v} (Compound) Pergolide
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Lisuride
Lisuride {u} (Compound) resembles {v} (Compound) Pergolide
Azelastine {u} (Compound) binds {v} (Gene) KCNH2
KCNH2 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Brompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pergolide
Azelastine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Methylergometrine
Methylergometrine {u} (Compound) resembles {v} (Compound) Pergolide
Azelastine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Cabergoline
Cabergoline {u} (Compound) resembles {v} (Compound) Pergolide
Azelastine {u} (Compound) causes {v} (Side Effect) Arthritis
Arthritis {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pergolide
Azelastine {u} (Compound) causes {v} (Side Effect) Increased appetite
Increased appetite {u} (Side Effect) is caused by {v} (Compound) Ioflupane I-123
Ioflupane I-123 {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pergolide
Azelastine (Compound) binds ADRA1B (Gene) and ADRA1B (Gene) is bound by Pergolide (Compound)
Azelastine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pergolide (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Pergolide
Azelastine (Compound) binds ADRA1B (Gene) and ADRA1B (Gene) is bound by Cabergoline (Compound) and Cabergoline (Compound) resembles Pergolide (Compound)
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Lisuride (Compound) and Lisuride (Compound) resembles Pergolide (Compound)
Azelastine (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Brompheniramine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Pergolide
Azelastine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Methylergometrine (Compound) and Methylergometrine (Compound) resembles Pergolide (Compound)
Azelastine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Cabergoline (Compound) and Cabergoline (Compound) resembles Pergolide (Compound)
Azelastine (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Pergolide
Azelastine (Compound) causes Increased appetite (Side Effect) and Increased appetite (Side Effect) is caused by Ioflupane I-123 (Compound) and Ioflupane I-123 may cause a moderate interaction that could exacerbate diseases when taken with Pergolide