DDInter504 DDInter1441
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. It is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold. Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Desipramine {u} (Compound) resembles {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Azatadine
Azatadine {u} (Compound) resembles {v} (Compound) Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenindamine
Desipramine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Azatadine
Azatadine {u} (Compound) resembles {v} (Compound) Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Azatadine
Azatadine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mirtazapine
Mirtazapine {u} (Compound) resembles {v} (Compound) Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Mirtazapine
Mirtazapine {u} (Compound) resembles {v} (Compound) Phenindamine
Desipramine {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cyclizine {u} (Compound) resembles {v} (Compound) Phenindamine
Desipramine (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Phenindamine (Compound)
Desipramine (Compound) resembles Azatadine (Compound) and Azatadine (Compound) resembles Phenindamine (Compound)
Desipramine (Compound) resembles Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine
Desipramine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Phenindamine (Compound)
Desipramine (Compound) resembles Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine
Desipramine (Compound) resembles Amitriptyline (Compound) and Amitriptyline (Compound) resembles Phenindamine (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine
Desipramine (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Azatadine (Compound) and Azatadine (Compound) resembles Phenindamine (Compound)
Desipramine (Compound) resembles Azatadine (Compound) and Azatadine (Compound) resembles Mirtazapine (Compound) and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Mirtazapine and Mirtazapine (Compound) resembles Phenindamine (Compound)
Desipramine (Compound) resembles Epinastine (Compound) and Epinastine (Compound) resembles Mirtazapine (Compound) and Mirtazapine (Compound) resembles Phenindamine (Compound)
Desipramine (Compound) resembles Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)