DDInter363 DDInter154
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) downregulates {v} (Gene) DERA
DERA {u} (Gene) is downregulated by {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) causes {v} (Side Effect) Dermatitis contact
Dermatitis contact {u} (Side Effect) is caused by {v} (Compound) Azelastine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Meclizine
Meclizine {u} (Compound) resembles {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) downregulates {v} (Gene) DERA
DERA {u} (Gene) is regulated by {v} (Gene) RPP38
RPP38 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Chlorpromazine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Azelastine
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Chlorpromazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Azelastine (Compound)
Chlorpromazine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Azelastine (Compound)
Chlorpromazine (Compound) downregulates DERA (Gene) and DERA (Gene) is downregulated by Azelastine (Compound)
Chlorpromazine (Compound) causes Dermatitis contact (Side Effect) and Dermatitis contact (Side Effect) is caused by Azelastine (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Chlorpromazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Meclizine (Compound) and Meclizine (Compound) resembles Azelastine (Compound)
Chlorpromazine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Azelastine (Compound)
Chlorpromazine (Compound) downregulates DERA (Gene) and DERA (Gene) is regulated by RPP38 (Gene) and RPP38 (Gene) is upregulated by Azelastine (Compound)
Chlorpromazine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Azelastine (Compound)