DDInter458 DDInter256
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) binds {v} (Gene) PPP3CA
PPP3CA {u} (Gene) interacts with {v} (Gene) GABRB2
GABRB2 {u} (Gene) is bound by {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAK2
TRAK2 {u} (Gene) interacts with {v} (Gene) GABRB2
GABRB2 {u} (Gene) is bound by {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is regulated by {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Butabarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) NUDT1
NUDT1 {u} (Gene) covaries with {v} (Gene) CHRNA4
CHRNA4 {u} (Gene) is bound by {v} (Compound) Butabarbital
Cyclosporine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Butabarbital (Compound)
Cyclosporine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Pentobarbital (Compound) and Pentobarbital (Compound) resembles Butabarbital (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Pentobarbital (Compound) and Pentobarbital (Compound) resembles Butabarbital (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Phenobarbital (Compound) and Phenobarbital (Compound) resembles Butabarbital (Compound)
Cyclosporine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Phenobarbital (Compound) and Phenobarbital (Compound) resembles Butabarbital (Compound)
Cyclosporine (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Pentobarbital (Compound) and Pentobarbital (Compound) resembles Butabarbital (Compound)
Cyclosporine (Compound) binds PPP3CA (Gene) and PPP3CA (Gene) interacts with GABRB2 (Gene) and GABRB2 (Gene) is bound by Butabarbital (Compound)
Cyclosporine (Compound) upregulates TRAK2 (Gene) and TRAK2 (Gene) interacts with GABRB2 (Gene) and GABRB2 (Gene) is bound by Butabarbital (Compound)
Cyclosporine (Compound) downregulates PNP (Gene) and PNP (Gene) is regulated by GABRA1 (Gene) and GABRA1 (Gene) is bound by Butabarbital (Compound)
Cyclosporine (Compound) downregulates NUDT1 (Gene) and NUDT1 (Gene) covaries with CHRNA4 (Gene) and CHRNA4 (Gene) is bound by Butabarbital (Compound)