DDInter162 DDInter1879
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Baclofen {u} (Compound) binds {v} (Gene) GABBR1
GABBR1 {u} (Gene) regulates {v} (Gene) CASP7
CASP7 {u} (Gene) is upregulated by {v} (Compound) Triprolidine
Baclofen {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Oxazepam
Oxazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) binds {v} (Gene) GABBR1
GABBR1 {u} (Gene) is bound by {v} (Compound) Vigabatrin
Vigabatrin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Secobarbital
Secobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Quazepam
Quazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pitolisant
Pitolisant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen {u} (Compound) is included by {v} (Pharmacologic Class) GABA A Agonists
GABA A Agonists {u} (Pharmacologic Class) includes {v} (Compound) Zaleplon
Zaleplon {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Baclofen (Compound) binds GABBR1 (Gene) and GABBR1 (Gene) regulates CASP7 (Gene) and CASP7 (Gene) is upregulated by Triprolidine (Compound)
Baclofen (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Oxazepam (Compound) and Oxazepam may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) binds GABBR1 (Gene) and GABBR1 (Gene) is bound by Vigabatrin (Compound) and Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Secobarbital (Compound) and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Quazepam (Compound) and Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant and Pitolisant may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Baclofen (Compound) is included by GABA A Agonists (Pharmacologic Class) and GABA A Agonists (Pharmacologic Class) includes Zaleplon (Compound) and Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine