DDInter255 DDInter489
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Busulfan {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Deferiprone
Busulfan {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Deferiprone
Busulfan {u} (Compound) causes {v} (Side Effect) Connective tissue disorder
Connective tissue disorder {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Busulfan {u} (Compound) upregulates {v} (Gene) NFATC3
NFATC3 {u} (Gene) is regulated by {v} (Gene) UGT1A6
UGT1A6 {u} (Gene) is bound by {v} (Compound) Deferiprone
Busulfan {u} (Compound) causes {v} (Side Effect) Multi-organ failure
Multi-organ failure {u} (Side Effect) is caused by {v} (Compound) Carfilzomib
Carfilzomib {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Busulfan {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) UGT1A6
UGT1A6 {u} (Gene) is bound by {v} (Compound) Deferiprone
Busulfan {u} (Compound) upregulates {v} (Gene) NFATC3
NFATC3 {u} (Gene) regulates {v} (Gene) BTK
BTK {u} (Gene) is upregulated by {v} (Compound) Deferiprone
Busulfan {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) PHKA1
PHKA1 {u} (Gene) is downregulated by {v} (Compound) Deferiprone
Busulfan {u} (Compound) upregulates {v} (Gene) NFATC3
NFATC3 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Irinotecan {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Busulfan {u} (Compound) downregulates {v} (Gene) CHEK2
CHEK2 {u} (Gene) regulates {v} (Gene) LPL
LPL {u} (Gene) is upregulated by {v} (Compound) Deferiprone
Busulfan (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Deferiprone (Compound)
Busulfan (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Busulfan (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Deferiprone
Busulfan (Compound) upregulates NFATC3 (Gene) and NFATC3 (Gene) is regulated by UGT1A6 (Gene) and UGT1A6 (Gene) is bound by Deferiprone (Compound)
Busulfan (Compound) causes Multi-organ failure (Side Effect) and Multi-organ failure (Side Effect) is caused by Carfilzomib (Compound) and Carfilzomib may lead to a major life threatening interaction when taken with Deferiprone
Busulfan (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by UGT1A6 (Gene) and UGT1A6 (Gene) is bound by Deferiprone (Compound)
Busulfan (Compound) upregulates NFATC3 (Gene) and NFATC3 (Gene) regulates BTK (Gene) and BTK (Gene) is upregulated by Deferiprone (Compound)
Busulfan (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by PHKA1 (Gene) and PHKA1 (Gene) is downregulated by Deferiprone (Compound)
Busulfan (Compound) upregulates NFATC3 (Gene) and NFATC3 (Gene) is upregulated by Irinotecan (Compound) and Irinotecan may lead to a major life threatening interaction when taken with Deferiprone
Busulfan (Compound) downregulates CHEK2 (Gene) and CHEK2 (Gene) regulates LPL (Gene) and LPL (Gene) is upregulated by Deferiprone (Compound)