DDInter150 DDInter1922
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Vecuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Vecuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vecuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Immune system disorder
Immune system disorder {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vecuronium
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Vecuronium
Azathioprine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) downregulates {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Vecuronium
Azathioprine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vecuronium
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Vecuronium
Azathioprine {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Lidocaine
Lidocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vecuronium
Azathioprine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Vecuronium
Azathioprine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Vecuronium (Compound)
Azathioprine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Rocuronium (Compound) and Rocuronium (Compound) resembles Vecuronium (Compound)
Azathioprine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Vecuronium
Azathioprine (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Vecuronium
Azathioprine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Pancuronium (Compound) and Pancuronium (Compound) resembles Vecuronium (Compound)
Azathioprine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) downregulates ABCB1 (Gene) and ABCB1 (Gene) is bound by Vecuronium (Compound)
Azathioprine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Vecuronium
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Vecuronium (Compound)
Azathioprine (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Lidocaine (Compound) and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Vecuronium
Azathioprine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Vecuronium (Compound)