DDInter364 DDInter809
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, deb
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glimepiride
Glimepiride {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Alcohol intolerance
Alcohol intolerance {u} (Side Effect) is caused by {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glimepiride
Glimepiride {u} may lead to a major life threatening interaction when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Chlorpropamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Chlorpropamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Gatifloxacin (Compound)
Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Gatifloxacin
Chlorpropamide (Compound) resembles Glimepiride (Compound) and Glimepiride may lead to a major life threatening interaction when taken with Gatifloxacin
Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may lead to a major life threatening interaction when taken with Gatifloxacin
Chlorpropamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Chlorpropamide (Compound) causes Alcohol intolerance (Side Effect) and Alcohol intolerance (Side Effect) is caused by Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Gatifloxacin
Chlorpropamide (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Capecitabine (Compound) and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Chlorpropamide (Compound) resembles Glimepiride (Compound) and Glimepiride may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Chlorpropamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Gatifloxacin