DDInter1730 DDInter1376
Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Sumatriptan {u} (Compound) resembles {v} (Compound) Naratriptan
Sumatriptan {u} (Compound) resembles {v} (Compound) Eletriptan
Sumatriptan {u} (Compound) binds {v} (Gene) ABCB1
Sumatriptan {u} (Compound) upregulates {v} (Gene) TIAM1
Sumatriptan {u} (Compound) palliates {v} (Disease) migraine
Sumatriptan {u} (Compound) is included by {v} (Pharmacologic Class) Serotonin 1d Receptor Agonists
Sumatriptan {u} (Compound) downregulates {v} (Gene) TIMM9
Sumatriptan {u} (Compound) causes {v} (Side Effect) Haematoma
Sumatriptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Sumatriptan {u} may lead to a major life threatening interaction when taken with {v} Fenfluramine
Sumatriptan (Compound) resembles Naratriptan (Compound)
Sumatriptan (Compound) resembles Eletriptan (Compound)
Sumatriptan (Compound) binds ABCB1 (Gene)
Sumatriptan (Compound) upregulates TIAM1 (Gene)
Sumatriptan (Compound) palliates migraine (Disease)
Sumatriptan (Compound) is included by Serotonin 1d Receptor Agonists (Pharmacologic Class)
Sumatriptan (Compound) downregulates TIMM9 (Gene)
Sumatriptan (Compound) causes Haematoma (Side Effect)
Sumatriptan may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Sumatriptan may lead to a major life threatening interaction when taken with Fenfluramine