DDInter1174 DDInter1139
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Mefenamic acid
Methotrexate {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Mefenamic acid
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Meclofenamic acid
Meclofenamic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate {u} (Compound) causes {v} (Side Effect) Cystitis noninfective
Cystitis noninfective {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Methotrexate may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) resembles Mefenamic acid (Compound)
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Mefenamic acid (Compound)
Methotrexate (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Mefenamic acid (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Mefenamic acid (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Mefenamic acid (Compound)
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Methotrexate (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Methotrexate (Compound) causes Cystitis noninfective (Side Effect) and Cystitis noninfective (Side Effect) is caused by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Mefenamic acid (Compound)