DDInter576 DDInter893
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of [quinacrine] with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.** Hydroxychloroquine was granted FDA approval on 18 April 1955. A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Hydroxychloroquine
Disulfiram {u} (Compound) causes {v} (Side Effect) Eruption
Eruption {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Amodiaquine
Amodiaquine {u} (Compound) resembles {v} (Compound) Hydroxychloroquine
Disulfiram {u} (Compound) causes {v} (Side Effect) Eruption
Eruption {u} (Side Effect) is caused by {v} (Compound) Chloroquine
Chloroquine {u} (Compound) resembles {v} (Compound) Hydroxychloroquine
Disulfiram {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxychloroquine
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis fulminant
Hepatitis fulminant {u} (Side Effect) is caused by {v} (Compound) Zafirlukast
Zafirlukast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Citalopram
Citalopram {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nefazodone
Nefazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis fulminant
Hepatitis fulminant {u} (Side Effect) is caused by {v} (Compound) Venlafaxine
Venlafaxine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Hydroxychloroquine (Compound)
Disulfiram (Compound) causes Eruption (Side Effect) and Eruption (Side Effect) is caused by Hydroxychloroquine (Compound)
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Amodiaquine (Compound) and Amodiaquine (Compound) resembles Hydroxychloroquine (Compound)
Disulfiram (Compound) causes Eruption (Side Effect) and Eruption (Side Effect) is caused by Chloroquine (Compound) and Chloroquine (Compound) resembles Hydroxychloroquine (Compound)
Disulfiram (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine
Disulfiram (Compound) causes Hepatitis fulminant (Side Effect) and Hepatitis fulminant (Side Effect) is caused by Zafirlukast (Compound) and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Citalopram (Compound) and Citalopram may lead to a major life threatening interaction when taken with Hydroxychloroquine
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound) and Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine
Disulfiram (Compound) causes Hepatitis fulminant (Side Effect) and Hepatitis fulminant (Side Effect) is caused by Venlafaxine (Compound) and Venlafaxine may lead to a major life threatening interaction when taken with Hydroxychloroquine