DDInter1276 DDInter1544
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Nelfinavir {u} (Compound) resembles {v} (Compound) Mitiglinide
Nelfinavir {u} (Compound) resembles {v} (Compound) Indinavir
Nelfinavir {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
Nelfinavir {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Nelfinavir {u} (Compound) upregulates {v} (Gene) AARS
Nelfinavir {u} (Compound) downregulates {v} (Gene) RPIA
Nelfinavir {u} (Compound) causes {v} (Side Effect) Injury
Nelfinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ranitidine
Nelfinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Nelfinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Nelfinavir (Compound) resembles Mitiglinide (Compound)
Nelfinavir (Compound) resembles Indinavir (Compound)
Nelfinavir (Compound) treats acquired immunodeficiency syndrome (Disease)
Nelfinavir (Compound) binds CYP3A7-CYP3A51P (Gene)
Nelfinavir (Compound) upregulates AARS (Gene)
Nelfinavir (Compound) downregulates RPIA (Gene)
Nelfinavir (Compound) causes Injury (Side Effect)
Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Ranitidine
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro