DDInter569 DDInter1181
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed
Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Methsuximide
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Glutethimide
Glutethimide {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Methsuximide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Methsuximide (Compound)
Diphenhydramine (Compound) resembles Phenytoin (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Methsuximide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Methsuximide (Compound)
Diphenhydramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Methsuximide (Compound)
Diphenhydramine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Methsuximide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Glutethimide (Compound) and Glutethimide (Compound) resembles Methsuximide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Phenytoin (Compound) and Phenytoin (Compound) resembles Methsuximide (Compound)
Diphenhydramine (Compound) resembles Phenytoin (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital (Compound) resembles Methsuximide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital (Compound) resembles Methsuximide (Compound)