DDInter1448 DDInter1376
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including the treatment of hypertensive episodes, prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and treatment of pharmacologically-induced mydriasis.[L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and topically.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Phentolamine {u} (Compound) resembles {v} (Compound) Naphazoline
Phentolamine {u} (Compound) resembles {v} (Compound) Antazoline
Phentolamine {u} (Compound) binds {v} (Gene) SIGMAR1
Phentolamine {u} (Compound) upregulates {v} (Gene) RAB4A
Phentolamine {u} (Compound) palliates {v} (Disease) hypertension
Phentolamine {u} (Compound) downregulates {v} (Gene) RPS4Y1
Phentolamine {u} (Compound) causes {v} (Side Effect) Tachycardia
Phentolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Insulin degludec
Phentolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Insulin human
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clozapine
Phentolamine (Compound) resembles Naphazoline (Compound)
Phentolamine (Compound) resembles Antazoline (Compound)
Phentolamine (Compound) binds SIGMAR1 (Gene)
Phentolamine (Compound) upregulates RAB4A (Gene)
Phentolamine (Compound) palliates hypertension (Disease)
Phentolamine (Compound) downregulates RPS4Y1 (Gene)
Phentolamine (Compound) causes Tachycardia (Side Effect)
Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Phentolamine may cause a minor interaction that can limit clinical effects when taken with Insulin human
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine