DDInter1928 DDInter278
Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications. Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Verapamil {u} (Compound) resembles {v} (Compound) Bevantolol
Verapamil {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Verapamil {u} (Compound) treats {v} (Disease) migraine
Verapamil {u} (Compound) binds {v} (Gene) CACNB2
Verapamil {u} (Compound) upregulates {v} (Gene) MCOLN1
Verapamil {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Verapamil {u} (Compound) downregulates {v} (Gene) DNAJA3
Verapamil {u} (Compound) causes {v} (Side Effect) Diarrhoea
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Verapamil (Compound) resembles Bevantolol (Compound)
Verapamil (Compound) resembles Trimethobenzamide (Compound)
Verapamil (Compound) treats migraine (Disease)
Verapamil (Compound) binds CACNB2 (Gene)
Verapamil (Compound) upregulates MCOLN1 (Gene)
Verapamil (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Verapamil (Compound) downregulates DNAJA3 (Gene)
Verapamil (Compound) causes Diarrhoea (Side Effect)
Verapamil may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Verapamil may cause a minor interaction that can limit clinical effects when taken with Bexarotene