DDInter1814 DDInter1853
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Tioguanine {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Tioguanine {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Tioguanine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Tioguanine {u} (Compound) binds {v} (Gene) IMPDH2
IMPDH2 {u} (Gene) interacts with {v} (Gene) IKBKE
IKBKE {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Tioguanine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Alitretinoin
Alitretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Tioguanine {u} (Compound) binds {v} (Gene) ABCC4
ABCC4 {u} (Gene) covaries with {v} (Gene) TSPAN4
TSPAN4 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Tioguanine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Tretinoin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Tioguanine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates NUCB2 (Gene) and NUCB2 (Gene) is downregulated by Tretinoin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Acitretin and Acitretin (Compound) resembles Tretinoin (Compound)
Tioguanine (Compound) binds IMPDH2 (Gene) and IMPDH2 (Gene) interacts with IKBKE (Gene) and IKBKE (Gene) is upregulated by Tretinoin (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Alitretinoin (Compound) and Alitretinoin (Compound) resembles Tretinoin (Compound)
Tioguanine (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) covaries with TSPAN4 (Gene) and TSPAN4 (Gene) is downregulated by Tretinoin (Compound)