DDInter543 DDInter1544
Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. Dicyclomine was granted FDA approval on 11 May 1950.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Dicyclomine {u} (Compound) binds {v} (Gene) CHRM3
Dicyclomine {u} (Compound) causes {v} (Side Effect) Transient global amnesia
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trichlormethiazide
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Dicyclomine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arbutamine
Dicyclomine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tacrine
Dicyclomine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Dicyclomine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Dicyclomine (Compound) binds CHRM3 (Gene)
Dicyclomine (Compound) causes Transient global amnesia (Side Effect)
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Digoxin
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Arbutamine
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Tacrine
Dicyclomine may lead to a major life threatening interaction when taken with Potassium chloride
Dicyclomine may lead to a major life threatening interaction when taken with Zonisamide