DDInter1453 DDInter504
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Clomipramine
Clomipramine {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Desipramine
Phenylephrine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Desipramine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Clomipramine
Clomipramine {u} (Compound) resembles {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Aprindine
Aprindine {u} (Compound) resembles {v} (Compound) Desipramine
Phenylephrine may lead to a major life threatening interaction when taken with Protriptyline and Protriptyline (Compound) resembles Desipramine (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Desipramine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Desipramine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Amitriptyline and Amitriptyline (Compound) resembles Desipramine (Compound)
Phenylephrine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Desipramine (Compound)
Phenylephrine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Desipramine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Protriptyline and Protriptyline (Compound) resembles Atomoxetine (Compound) and Atomoxetine (Compound) resembles Desipramine (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Protriptyline (Compound) and Protriptyline (Compound) resembles Desipramine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Promazine (Compound) and Promazine (Compound) resembles Desipramine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Amitriptyline and Amitriptyline (Compound) resembles Aprindine (Compound) and Aprindine (Compound) resembles Desipramine (Compound)