DDInter419 DDInter150
Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine receptors results in fewer extrapyramidal side effects, especially tardive dyskinesia. However, its promiscuity toward the muscarinic and adrenergic receptors can result in other side effects, notably gastrointestinal hypomotility and orthostatic hypotension. [L905,A215552]. Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis.[A256713,A256718] However, continued evidence of its effectiveness led to clozapine's eventual reintroduction, although
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Clozapine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Tioguanine
Tioguanine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Azathioprine
Clozapine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Mercaptopurine
Mercaptopurine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Azathioprine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Tioguanine
Tioguanine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Leflunomide {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Tioguanine
Tioguanine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Clozapine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Dapsone
Dapsone {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Clozapine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) FABP5
FABP5 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Clozapine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Tioguanine and Tioguanine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Azathioprine (Compound)
Clozapine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Mercaptopurine and Mercaptopurine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Azathioprine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Tioguanine and Tioguanine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Tioguanine and Tioguanine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Azathioprine (Compound)
Clozapine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Dapsone and Dapsone (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Clozapine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by FABP5 (Gene) and FABP5 (Gene) is downregulated by Azathioprine (Compound)