DDInter1528 DDInter1544
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Procyclidine {u} (Compound) resembles {v} (Compound) Oxyphencyclimine
Procyclidine {u} (Compound) binds {v} (Gene) CHRM2
Procyclidine {u} (Compound) upregulates {v} (Gene) PTGS2
Procyclidine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Procyclidine {u} (Compound) downregulates {v} (Gene) JMJD6
Procyclidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Procyclidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Procyclidine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Procyclidine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glycopyrronium
Procyclidine (Compound) resembles Oxyphencyclimine (Compound)
Procyclidine (Compound) binds CHRM2 (Gene)
Procyclidine (Compound) upregulates PTGS2 (Gene)
Procyclidine (Compound) palliates Parkinson's disease (Disease)
Procyclidine (Compound) downregulates JMJD6 (Gene)
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Trospium
Procyclidine may lead to a major life threatening interaction when taken with Potassium chloride
Procyclidine (Compound) resembles Glycopyrronium (Compound) and Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium