DDInter716 DDInter1376
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Felodipine {u} (Compound) resembles {v} (Compound) Amlodipine
Felodipine {u} (Compound) resembles {v} (Compound) Isradipine
Felodipine {u} (Compound) treats {v} (Disease) hypertension
Felodipine {u} (Compound) binds {v} (Gene) CACNA1S
Felodipine {u} (Compound) upregulates {v} (Gene) CGRRF1
Felodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Felodipine {u} (Compound) downregulates {v} (Gene) GJA1
Felodipine {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Felodipine (Compound) resembles Amlodipine (Compound)
Felodipine (Compound) resembles Isradipine (Compound)
Felodipine (Compound) treats hypertension (Disease)
Felodipine (Compound) binds CACNA1S (Gene)
Felodipine (Compound) upregulates CGRRF1 (Gene)
Felodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Felodipine (Compound) downregulates GJA1 (Gene)
Felodipine (Compound) causes Sexual dysfunction (Side Effect)
Felodipine may cause a minor interaction that can limit clinical effects when taken with Theophylline
Felodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor