DDInter705 DDInter119
Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Exemestane {u} (Compound) resembles {v} (Compound) Loteprednol
Exemestane {u} (Compound) resembles {v} (Compound) Dydrogesterone
Exemestane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conjugated estrogens
Exemestane {u} (Compound) treats {v} (Disease) breast cancer
Exemestane {u} (Compound) binds {v} (Gene) CYP19A1
Exemestane {u} (Compound) upregulates {v} (Gene) GLRX
Exemestane {u} (Compound) downregulates {v} (Gene) IGFBP3
Exemestane {u} (Compound) causes {v} (Side Effect) Visual disturbance
Exemestane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Exemestane {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Exemestane (Compound) resembles Loteprednol (Compound)
Exemestane (Compound) resembles Dydrogesterone (Compound)
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens
Exemestane (Compound) treats breast cancer (Disease)
Exemestane (Compound) binds CYP19A1 (Gene)
Exemestane (Compound) upregulates GLRX (Gene)
Exemestane (Compound) downregulates IGFBP3 (Gene)
Exemestane (Compound) causes Visual disturbance (Side Effect)
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Exemestane may lead to a major life threatening interaction when taken with Thalidomide