DDInter405 DDInter490
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Clofarabine {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Deferoxamine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyrazinamide
Pyrazinamide {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Deferoxamine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Deferoxamine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyrazinamide
Pyrazinamide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Deferoxamine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Deferoxamine
Clofarabine {u} (Compound) upregulates {v} (Gene) HBEGF
HBEGF {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Deferoxamine
Clofarabine {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Deferiprone {u} (Compound) is included by {v} (Pharmacologic Class) Iron Chelating Activity
Iron Chelating Activity {u} (Pharmacologic Class) includes {v} (Compound) Deferoxamine
Clofarabine {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Iohexol {u} (Compound) causes {v} (Side Effect) Injection site pain
Injection site pain {u} (Side Effect) is caused by {v} (Compound) Deferoxamine
Clofarabine {u} (Compound) resembles {v} (Compound) Regadenoson
Regadenoson {u} (Compound) causes {v} (Side Effect) Injection site pain
Injection site pain {u} (Side Effect) is caused by {v} (Compound) Deferoxamine
Clofarabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Ofloxacin {u} (Compound) causes {v} (Side Effect) Injection site pain
Injection site pain {u} (Side Effect) is caused by {v} (Compound) Deferoxamine
Clofarabine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Deferoxamine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pyrazinamide and Pyrazinamide (Compound) binds XDH (Gene) and XDH (Gene) is bound by Deferoxamine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Deferoxamine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Pyrazinamide and Pyrazinamide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Deferoxamine (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Deferoxamine (Compound)
Clofarabine (Compound) upregulates HBEGF (Gene) and HBEGF (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Deferoxamine (Compound)
Clofarabine may lead to a major life threatening interaction when taken with Deferiprone and Deferiprone (Compound) is included by Iron Chelating Activity (Pharmacologic Class) and Iron Chelating Activity (Pharmacologic Class) includes Deferoxamine (Compound)
Clofarabine may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) causes Injection site pain (Side Effect) and Injection site pain (Side Effect) is caused by Deferoxamine (Compound)
Clofarabine (Compound) resembles Regadenoson (Compound) and Regadenoson (Compound) causes Injection site pain (Side Effect) and Injection site pain (Side Effect) is caused by Deferoxamine (Compound)
Clofarabine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) causes Injection site pain (Side Effect) and Injection site pain (Side Effect) is caused by Deferoxamine (Compound)