DDInter395 DDInter1397
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Clemastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Clemastine {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Clemastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) regulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) upregulates {v} (Gene) FDFT1
FDFT1 {u} (Gene) is regulated by {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) interacts with {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is regulated by {v} (Gene) DHCR24
DHCR24 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Clemastine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Clemastine (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Clemastine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Paroxetine (Compound)
Clemastine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Paroxetine (Compound)
Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Clemastine (Compound) upregulates LIPA (Gene) and LIPA (Gene) regulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Clemastine (Compound) upregulates FDFT1 (Gene) and FDFT1 (Gene) is regulated by SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)
Clemastine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) interacts with SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)
Clemastine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is regulated by DHCR24 (Gene) and DHCR24 (Gene) is upregulated by Paroxetine (Compound)
Clemastine (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)