DDInter458 DDInter392
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Cyclosporine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is bound by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Cladribine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Clofarabine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cyclosporine {u} (Compound) downregulates {v} (Gene) RRM2
RRM2 {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Clofarabine
Clofarabine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cyclosporine (Compound) downregulates PNP (Gene) and PNP (Gene) is bound by Cladribine (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Cladribine (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Cladribine (Compound)
Cyclosporine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Cladribine (Compound)
Cyclosporine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Cladribine (Compound)
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Cladribine (Compound)
Cyclosporine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Cladribine (Compound)
Cyclosporine (Compound) downregulates PNP (Gene) and PNP (Gene) is upregulated by Clofarabine (Compound) and Clofarabine may lead to a major life threatening interaction when taken with Cladribine
Cyclosporine (Compound) downregulates RRM2 (Gene) and RRM2 (Gene) is downregulated by Azacitidine (Compound) and Azacitidine may lead to a major life threatening interaction when taken with Cladribine
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Clofarabine (Compound) and Clofarabine may lead to a major life threatening interaction when taken with Cladribine