DDInter687 DDInter1956
Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids. It is used to treat or manage a variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA).
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Etanercept {u} may lead to a major life threatening interaction when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etanercept {u} may lead to a major life threatening interaction when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etanercept {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Vitamin E {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human adenovirus e serotype 4 strain cl-68578 antigen
Human adenovirus e serotype 4 strain cl-68578 antigen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etanercept {u} may lead to a major life threatening interaction when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Ethionamide {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Etanercept {u} may lead to a major life threatening interaction when taken with {v} Cytarabine
Cytarabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Zalcitabine
Etanercept {u} may lead to a major life threatening interaction when taken with {v} Cytarabine
Cytarabine {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Zalcitabine
Etanercept may lead to a major life threatening interaction when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) resembles Zalcitabine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Cytarabine and Cytarabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen and Human adenovirus e serotype 4 strain cl-68578 antigen may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Cytarabine and Cytarabine (Compound) resembles Decitabine (Compound) and Decitabine (Compound) resembles Zalcitabine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Zalcitabine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Cytarabine and Cytarabine (Compound) binds DCK (Gene) and DCK (Gene) is bound by Zalcitabine (Compound)
Etanercept may lead to a major life threatening interaction when taken with Cytarabine and Cytarabine (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Zalcitabine (Compound)