DDInter1543 DDInter1180
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, alpha<sub>1</sub
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Protriptyline {u} (Compound) resembles {v} (Compound) Maprotiline
Protriptyline {u} (Compound) resembles {v} (Compound) Cyclobenzaprine
Protriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Protriptyline {u} (Compound) binds {v} (Gene) CYP2D6
Protriptyline {u} (Compound) upregulates {v} (Gene) MAP7
Protriptyline {u} (Compound) downregulates {v} (Gene) NUP93
Protriptyline {u} (Compound) causes {v} (Side Effect) Parotid swelling
Protriptyline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Protriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Protriptyline {u} may lead to a major life threatening interaction when taken with {v} Pasireotide
Protriptyline (Compound) resembles Maprotiline (Compound)
Protriptyline (Compound) resembles Cyclobenzaprine (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Protriptyline (Compound) binds CYP2D6 (Gene)
Protriptyline (Compound) upregulates MAP7 (Gene)
Protriptyline (Compound) downregulates NUP93 (Gene)
Protriptyline (Compound) causes Parotid swelling (Side Effect)
Protriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Protriptyline may lead to a major life threatening interaction when taken with Pasireotide