DDInter740 DDInter393
Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Flecainide {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Flecainide {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Flecainide {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Flecainide {u} (Compound) resembles {v} (Compound) Mefloquine
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Flecainide {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is regulated by {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Flecainide {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Flecainide {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Flecainide {u} (Compound) causes {v} (Side Effect) Tinnitus
Tinnitus {u} (Side Effect) is caused by {v} (Compound) Erythromycin
Erythromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Flecainide {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Azithromycin
Azithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Flecainide {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Flecainide (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Clarithromycin (Compound)
Flecainide (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Clarithromycin (Compound)
Flecainide (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Flecainide (Compound) resembles Mefloquine (Compound) and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Flecainide (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is regulated by CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compound)
Flecainide (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Flecainide (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Flecainide (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Erythromycin (Compound) and Erythromycin (Compound) resembles Clarithromycin (Compound)
Flecainide (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Azithromycin (Compound) and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Flecainide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin