DDInter458 DDInter431
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) upregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is upregulated by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inhibitors
Cytochrome P450 3A4 Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Colchicine
Cyclosporine {u} (Compound) upregulates {v} (Gene) BET1
BET1 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNE2
CCNE2 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) interacts with {v} (Gene) LONP1
LONP1 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tofisopam
Tofisopam {u} (Compound) resembles {v} (Compound) Colchicine
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Colchicine (Compound)
Cyclosporine (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Colchicine (Compound)
Cyclosporine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is upregulated by Colchicine (Compound)
Cyclosporine (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Colchicine (Compound)
Cyclosporine (Compound) upregulates BET1 (Gene) and BET1 (Gene) is downregulated by Colchicine (Compound)
Cyclosporine (Compound) downregulates CCNE2 (Gene) and CCNE2 (Gene) is downregulated by Colchicine (Compound)
Cyclosporine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Colchicine (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) interacts with LONP1 (Gene) and LONP1 (Gene) is upregulated by Colchicine (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is upregulated by Colchicine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tofisopam (Compound) and Tofisopam (Compound) resembles Colchicine (Compound)