DDInter853 DDInter154
Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within the mesolimbic and mesocortical systems of the brain. Haloperidol is indicated for the treatment of the manifestations of several psychotic disorders including schizophrenia, acute psychosis, Tourette syndrome, and other severe behavioural states. It is also used off-label for the management of chorea associated with Huntington's disease and for the treatment of intractable hiccups as it is a potent antiemetic. Dopamine-antagonizing medications such as haloperidol are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Haloperidol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol {u} (Compound) resembles {v} (Compound) Mazindol
Mazindol {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Azelastine
Haloperidol {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Haloperidol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol {u} (Compound) resembles {v} (Compound) Mazindol
Mazindol {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Meclizine
Meclizine {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) EPCAM
EPCAM {u} (Gene) is upregulated by {v} (Compound) Azelastine
Haloperidol {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Buclizine
Buclizine {u} (Compound) resembles {v} (Compound) Azelastine
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Haloperidol (Compound) resembles Mazindol (Compound) and Mazindol (Compound) resembles Azelastine (Compound)
Haloperidol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Azelastine (Compound)
Haloperidol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Haloperidol (Compound) resembles Mazindol (Compound) and Mazindol (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Azelastine (Compound)
Haloperidol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Meclizine (Compound) and Meclizine (Compound) resembles Azelastine (Compound)
Haloperidol (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates EPCAM (Gene) and EPCAM (Gene) is upregulated by Azelastine (Compound)
Haloperidol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Buclizine (Compound) and Buclizine (Compound) resembles Azelastine (Compound)