DDInter393 DDInter125
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Clarithromycin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Asenapine
Clarithromycin {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Clarithromycin {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clobazam
Clobazam {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Clarithromycin {u} may lead to a major life threatening interaction when taken with {v} Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Clarithromycin {u} may lead to a major life threatening interaction when taken with {v} Quetiapine
Quetiapine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Asenapine (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Asenapine (Compound)
Clarithromycin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Clarithromycin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)
Clarithromycin may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Clarithromycin may lead to a major life threatening interaction when taken with Quetiapine and Quetiapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)