DDInter1209 DDInter1747
Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of fungal CYP450 14α-lanosterol demethylase activity.[A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.[A214523, L14021] It is currently available as a variety of prescription and over the counter products. Despite having been in clinical use for an extended period, resistance to m
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Miconazole {u} (Compound) resembles {v} (Compound) Tioconazole
Miconazole {u} (Compound) resembles {v} (Compound) Triclosan
Miconazole {u} (Compound) binds {v} (Gene) KCNMB1
Miconazole {u} (Compound) upregulates {v} (Gene) KIT
Miconazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Miconazole {u} (Compound) downregulates {v} (Gene) STUB1
Miconazole {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Escitalopram
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tofacitinib
Miconazole (Compound) resembles Tioconazole (Compound)
Miconazole (Compound) resembles Triclosan (Compound)
Miconazole (Compound) binds KCNMB1 (Gene)
Miconazole (Compound) upregulates KIT (Gene)
Miconazole (Compound) is included by Azoles (Pharmacologic Class)
Miconazole (Compound) downregulates STUB1 (Gene)
Miconazole (Compound) causes Mediastinal disorder (Side Effect)
Miconazole may cause a minor interaction that can limit clinical effects when taken with Escitalopram
Miconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib