DDInter1164 DDInter808
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. Another well-known benefit of this drug is modest weight loss, making it an effective choice for obese patients type II diabetes. Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the US in 1995.
Garlic allergenic extract is used in allergenic testing.
Metformin {u} (Compound) treats {v} (Disease) polycystic ovary syndrome
Metformin {u} (Compound) binds {v} (Gene) NDUFS8
Metformin {u} (Compound) upregulates {v} (Gene) SLC25A4
Metformin {u} (Compound) is included by {v} (Pharmacologic Class) Biguanides
Metformin {u} (Compound) downregulates {v} (Gene) TOMM34
Metformin {u} (Compound) causes {v} (Side Effect) Asthenia
Metformin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lipoic acid
Metformin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Memantine
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trifluoperazine
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Metformin (Compound) treats polycystic ovary syndrome (Disease)
Metformin (Compound) binds NDUFS8 (Gene)
Metformin (Compound) upregulates SLC25A4 (Gene)
Metformin (Compound) is included by Biguanides (Pharmacologic Class)
Metformin (Compound) downregulates TOMM34 (Gene)
Metformin (Compound) causes Asthenia (Side Effect)
Metformin may cause a minor interaction that can limit clinical effects when taken with Lipoic acid
Metformin may cause a minor interaction that can limit clinical effects when taken with Memantine
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro