DDInter336 DDInter747
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position of the steroid structure - this fluorination is thought to be crucial to fludrocortisone's significant mineralocorticoid potency.
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Testosterone
Testosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Rash maculo-papular
Rash maculo-papular {u} (Side Effect) is caused by {v} (Compound) Dabrafenib
Dabrafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Celecoxib {u} (Compound) binds {v} (Gene) CA14
CA14 {u} (Gene) is bound by {v} (Compound) Acetazolamide
Acetazolamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Formoterol
Formoterol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludrocortisone
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Prednisone
Prednisone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Celecoxib {u} (Compound) causes {v} (Side Effect) Ecchymosis
Ecchymosis {u} (Side Effect) is caused by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludrocortisone
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Fludrocortisone (Compound)
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Celecoxib (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Fludrocortisone (Compound)
Celecoxib (Compound) causes Rash maculo-papular (Side Effect) and Rash maculo-papular (Side Effect) is caused by Dabrafenib (Compound) and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Celecoxib (Compound) binds CA14 (Gene) and CA14 (Gene) is bound by Acetazolamide (Compound) and Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) is bound by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Celecoxib (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Formoterol (Compound) and Formoterol may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Prednisone (Compound) and Prednisone (Compound) resembles Fludrocortisone (Compound)
Celecoxib (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Ticlopidine (Compound) and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone