DDInter1956 DDInter298
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Zalcitabine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) downregulates {v} (Gene) TUBA1A
TUBA1A {u} (Gene) is downregulated by {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) downregulates {v} (Gene) TUBA1A
TUBA1A {u} (Gene) is regulated by {v} (Gene) SOD1
SOD1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is associated with {v} (Disease) bone cancer
bone cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) downregulates {v} (Gene) ZW10
ZW10 {u} (Gene) is associated with {v} (Disease) bone cancer
bone cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is upregulated by {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is regulated by {v} (Gene) SOD1
SOD1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Zalcitabine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) interacts with {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Zalcitabine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Carboplatin (Compound)
Zalcitabine (Compound) downregulates TUBA1A (Gene) and TUBA1A (Gene) is downregulated by ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Carboplatin (Compound)
Zalcitabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Carboplatin (Compound)
Zalcitabine (Compound) downregulates TUBA1A (Gene) and TUBA1A (Gene) is regulated by SOD1 (Gene) and SOD1 (Gene) is bound by Carboplatin (Compound)
Zalcitabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is associated with bone cancer (Disease) and bone cancer (Disease) is treated by Carboplatin (Compound)
Zalcitabine (Compound) downregulates ZW10 (Gene) and ZW10 (Gene) is associated with bone cancer (Disease) and bone cancer (Disease) is treated by Carboplatin (Compound)
Zalcitabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Carboplatin (Compound)
Zalcitabine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is upregulated by breast cancer (Disease) and breast cancer (Disease) is treated by Carboplatin (Compound)
Zalcitabine (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is regulated by SOD1 (Gene) and SOD1 (Gene) is bound by Carboplatin (Compound)
Zalcitabine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) interacts with NQO1 (Gene) and NQO1 (Gene) is bound by Carboplatin (Compound)