DDInter1323 DDInter675
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is a life-threatening disease requiring life-long management. Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural hormone, somatostatin, which inhibits the secretion of growth hormone. Additionally, it is used for the treatment of acromegaly and symptoms arising from various tumors, including carcinoid tumors and vasoactive intestinal tumors (VIPomas). In the past, octreotide has been administered solely by injection. On June 26, 2020, the first approved delayed-release oral somatostatin analog, Mycapssa, received FDA approval for the long term maintenance
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisoprolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Esmolol
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisoprolol
Bisoprolol {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Metipranolol
Metipranolol {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Esmolol
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propafenone
Propafenone {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Esmolol
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propafenone
Propafenone {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Esmolol
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Esmolol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Esmolol (Compound)
Octreotide (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Esmolol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Esmolol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Metipranolol (Compound) and Metipranolol (Compound) resembles Esmolol (Compound)
Octreotide (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Oxprenolol (Compound) and Oxprenolol (Compound) resembles Esmolol (Compound)
Octreotide (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Acebutolol (Compound) and Acebutolol (Compound) resembles Esmolol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Compound) resembles Ibuprofen (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Esmolol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Esmolol (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Esmolol (Compound)