DDInter1243 DDInter448
An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers robust effectiveness in treating NSCLC in patients with this type of rearrangement. Crizotinib was the first-in-class drug used to treat ALK-positive tumors. Second- and third-generation ALK-tyrosine kinase-inhibitors have overcome many of the pharmacodynamic and genetic resistance mechanisms crizotinib is prone to. Crizotinib was approved by the FDA in 2011, and its use is accompanied by FDA-approved tests used to detect ALK and ROS1 rearrangements.
Moricizine {u} (Compound) upregulates {v} (Gene) PXMP2
PXMP2 {u} (Gene) is downregulated by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Moricizine {u} (Compound) upregulates {v} (Gene) PXMP2
PXMP2 {u} (Gene) is regulated by {v} (Gene) ABL2
ABL2 {u} (Gene) is bound by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} (Compound) upregulates {v} (Gene) CDK7
CDK7 {u} (Gene) is bound by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is upregulated by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Propericiazine
Propericiazine {u} (Compound) resembles {v} (Compound) Perphenazine
Perphenazine {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Propericiazine
Propericiazine {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Crizotinib
Moricizine {u} (Compound) resembles {v} (Compound) Acepromazine
Acepromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Moricizine (Compound) upregulates PXMP2 (Gene) and PXMP2 (Gene) is downregulated by Crizotinib (Compound)
Moricizine (Compound) resembles Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Crizotinib
Moricizine (Compound) upregulates PXMP2 (Gene) and PXMP2 (Gene) is regulated by ABL2 (Gene) and ABL2 (Gene) is bound by Crizotinib (Compound)
Moricizine (Compound) resembles Thioridazine (Compound) and Thioridazine (Compound) upregulates CDK7 (Gene) and CDK7 (Gene) is bound by Crizotinib (Compound)
Moricizine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Crizotinib (Compound)
Moricizine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Crizotinib (Compound)
Moricizine (Compound) resembles Propericiazine (Compound) and Propericiazine (Compound) resembles Perphenazine (Compound) and Perphenazine may lead to a major life threatening interaction when taken with Crizotinib
Moricizine (Compound) resembles Propericiazine (Compound) and Propericiazine (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Crizotinib (Compound)
Moricizine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Crizotinib (Compound)
Moricizine (Compound) resembles Acepromazine (Compound) and Acepromazine (Compound) resembles Clomipramine (Compound) and Clomipramine may lead to a major life threatening interaction when taken with Crizotinib