DDInter416 DDInter223
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Bosentan
Clotrimazole {u} (Compound) causes {v} (Side Effect) Pollakiuria
Pollakiuria {u} (Side Effect) is caused by {v} (Compound) Bosentan
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bosentan
Clotrimazole {u} (Compound) causes {v} (Side Effect) Pollakiuria
Pollakiuria {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bosentan
Clotrimazole {u} (Compound) causes {v} (Side Effect) Cystitis noninfective
Cystitis noninfective {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bosentan
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Bosentan
Clotrimazole {u} (Compound) resembles {v} (Compound) Sulfinpyrazone
Sulfinpyrazone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bosentan
Clotrimazole {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Dronabinol
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bosentan
Clotrimazole {u} (Compound) resembles {v} (Compound) Bifonazole
Bifonazole {u} (Compound) resembles {v} (Compound) Letrozole
Letrozole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bosentan
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) causes {v} (Side Effect) Muscle twitching
Muscle twitching {u} (Side Effect) is caused by {v} (Compound) Bosentan
Clotrimazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bosentan (Compound)
Clotrimazole (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Bosentan (Compound)
Clotrimazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bosentan
Clotrimazole (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Bosentan
Clotrimazole (Compound) causes Cystitis noninfective (Side Effect) and Cystitis noninfective (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Bosentan
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bosentan (Compound)
Clotrimazole (Compound) resembles Sulfinpyrazone (Compound) and Sulfinpyrazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosentan (Compound)
Clotrimazole (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dronabinol (Compound) and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Bosentan
Clotrimazole (Compound) resembles Bifonazole (Compound) and Bifonazole (Compound) resembles Letrozole (Compound) and Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Bosentan
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) causes Muscle twitching (Side Effect) and Muscle twitching (Side Effect) is caused by Bosentan (Compound)