DDInter1287 DDInter1676
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Nicardipine {u} (Compound) resembles {v} (Compound) Felodipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Nicardipine {u} (Compound) treats {v} (Disease) hypertension
Nicardipine {u} (Compound) binds {v} (Gene) PDE1A
Nicardipine {u} (Compound) upregulates {v} (Gene) NNT
Nicardipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Nicardipine {u} (Compound) downregulates {v} (Gene) CAST
Nicardipine {u} (Compound) causes {v} (Side Effect) Nervousness
Nicardipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Nicardipine (Compound) resembles Felodipine (Compound)
Nicardipine (Compound) resembles Clevidipine (Compound)
Nicardipine (Compound) treats hypertension (Disease)
Nicardipine (Compound) binds PDE1A (Gene)
Nicardipine (Compound) upregulates NNT (Gene)
Nicardipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Nicardipine (Compound) downregulates CAST (Gene)
Nicardipine (Compound) causes Nervousness (Side Effect)
Nicardipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid