DDInter1873 DDInter1662
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Trimethobenzamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Coma
Coma {u} (Side Effect) is caused by {v} (Compound) Sertraline
Trimethobenzamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Cisapride
Cisapride {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) downregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Verapamil
Verapamil {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Cisapride
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Trimethobenzamide (Compound) causes Coma (Side Effect) and Coma (Side Effect) is caused by Sertraline (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Trimethobenzamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Trimethobenzamide (Compound) resembles Papaverine (Compound) and Papaverine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Sertraline (Compound)
Trimethobenzamide (Compound) resembles Cisapride (Compound) and Cisapride (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Sertraline (Compound)
Trimethobenzamide (Compound) resembles Papaverine (Compound) and Papaverine (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Sertraline (Compound)
Trimethobenzamide (Compound) resembles Verapamil (Compound) and Verapamil (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Sertraline (Compound)
Trimethobenzamide (Compound) resembles Cisapride (Compound) and Cisapride may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Trimethobenzamide (Compound) resembles Papaverine (Compound) and Papaverine (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sertraline (Compound)