DDInter336 DDInter815
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams. This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.
Celecoxib {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Tobramycin
Tobramycin {u} (Compound) resembles {v} (Compound) Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Anaphylactoid reaction {u} (Side Effect) is caused by {v} (Compound) Perindopril
Perindopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypokalaemia
Hypokalaemia {u} (Side Effect) is caused by {v} (Compound) Piperacillin
Piperacillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Neomycin
Neomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Foscarnet
Foscarnet {u} may lead to a major life threatening interaction when taken with {v} Gentamicin
Celecoxib {u} (Compound) causes {v} (Side Effect) Hearing impaired
Hearing impaired {u} (Side Effect) is caused by {v} (Compound) Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) interacts with {v} (Gene) LRP2
LRP2 {u} (Gene) is bound by {v} (Compound) Gentamicin
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is associated with {v} (Gene) LRP2
LRP2 {u} (Gene) is bound by {v} (Compound) Gentamicin
Celecoxib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Celecoxib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Tobramycin (Compound) and Tobramycin (Compound) resembles Gentamicin (Compound)
Celecoxib (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Perindopril (Compound) and Perindopril may cause a minor interaction that can limit clinical effects when taken with Gentamicin
Celecoxib (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Piperacillin (Compound) and Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Celecoxib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Neomycin (Compound) and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Celecoxib (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Gentamicin
Celecoxib (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Foscarnet (Compound) and Foscarnet may lead to a major life threatening interaction when taken with Gentamicin
Celecoxib (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Kanamycin (Compound) and Kanamycin (Compound) resembles Gentamicin (Compound) and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) interacts with LRP2 (Gene) and LRP2 (Gene) is bound by Gentamicin (Compound)
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is associated with LRP2 (Gene) and LRP2 (Gene) is bound by Gentamicin (Compound)