DDInter596 DDInter783
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) upregulates {v} (Gene) IL13RA1
IL13RA1 {u} (Gene) is upregulated by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Methylphenobarbital
Methylphenobarbital {u} (Compound) resembles {v} (Compound) Fosphenytoin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fosphenytoin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Coordination abnormal
Coordination abnormal {u} (Side Effect) is caused by {v} (Compound) Ixabepilone
Ixabepilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Doxorubicin (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Fosphenytoin (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Modafinil (Compound) and Modafinil (Compound) resembles Fosphenytoin (Compound)
Doxorubicin (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Doxorubicin (Compound) upregulates IL13RA1 (Gene) and IL13RA1 (Gene) is upregulated by Modafinil (Compound) and Modafinil (Compound) resembles Fosphenytoin (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Doxorubicin (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Methylphenobarbital (Compound) and Methylphenobarbital (Compound) resembles Fosphenytoin (Compound)
Doxorubicin (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Fosphenytoin
Doxorubicin (Compound) causes Coordination abnormal (Side Effect) and Coordination abnormal (Side Effect) is caused by Ixabepilone (Compound) and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin