DDInter260 DDInter535
Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Cabergoline {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) regulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Cabergoline {u} (Compound) resembles {v} (Compound) Lisuride
Lisuride {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Cabergoline {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) regulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Cabergoline (Compound) upregulates AGL (Gene) and AGL (Gene) is upregulated by Diazoxide (Compound)
Cabergoline (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diazoxide (Compound)
Cabergoline (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Cabergoline (Compound) upregulates AGL (Gene) and AGL (Gene) regulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Cabergoline (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Cabergoline (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Cabergoline (Compound) resembles Lisuride (Compound) and Lisuride (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Diazoxide (Compound)
Cabergoline (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Cabergoline (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Cabergoline (Compound) upregulates AGL (Gene) and AGL (Gene) regulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Diazoxide (Compound)