DDInter212 DDInter1676
Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Bisacodyl {u} (Compound) resembles {v} (Compound) Carbinoxamine
Bisacodyl {u} (Compound) resembles {v} (Compound) Dexbrompheniramine
Bisacodyl {u} (Compound) binds {v} (Gene) GPR55
Bisacodyl {u} (Compound) upregulates {v} (Gene) KTN1
Bisacodyl {u} (Compound) is included by {v} (Pharmacologic Class) Stimulation Large Intestine Fluid/Electrolyte Secretion
Bisacodyl {u} (Compound) downregulates {v} (Gene) MTMR4
Bisacodyl {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Bisacodyl {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomefloxacin
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pitolisant
Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Bisacodyl (Compound) resembles Dexbrompheniramine (Compound)
Bisacodyl (Compound) binds GPR55 (Gene)
Bisacodyl (Compound) upregulates KTN1 (Gene)
Bisacodyl (Compound) is included by Stimulation Large Intestine Fluid/Electrolyte Secretion (Pharmacologic Class)
Bisacodyl (Compound) downregulates MTMR4 (Gene)
Bisacodyl (Compound) causes Nervous system disorder (Side Effect)
Bisacodyl may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant