DDInter802 DDInter1180
Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sources, such as _Galanthus nivalis_. Galantamine was first studied in paralytic and neuropathic conditions, such as myopathies and postpolio paralytic conditions, and for reversal of neuromuscular blockade.[A182993,A201968] Following the discovery of its AChE-inhibiting properties, the cognitive effects of galantamine were studied in a wide variety of psychiatric disorders such as mild cognitive impairment, cognitive impairment in schizophrenia and bipolar disorder, and autism; however, re-development of the drug for Alzheimer’s disease did not commence until the early 1990s due to difficulties in extraction and
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Galantamine {u} (Compound) resembles {v} (Compound) Codeine
Galantamine {u} (Compound) treats {v} (Disease) Alzheimer's disease
Galantamine {u} (Compound) binds {v} (Gene) CHRND
Galantamine {u} (Compound) upregulates {v} (Gene) HERC6
Galantamine {u} (Compound) downregulates {v} (Gene) MBOAT7
Galantamine {u} (Compound) causes {v} (Side Effect) Hypotension
Galantamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Galantamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Galantamine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Galantamine (Compound) resembles Dihydrocodeine (Compound)
Galantamine (Compound) resembles Codeine (Compound)
Galantamine (Compound) treats Alzheimer's disease (Disease)
Galantamine (Compound) binds CHRND (Gene)
Galantamine (Compound) upregulates HERC6 (Gene)
Galantamine (Compound) downregulates MBOAT7 (Gene)
Galantamine (Compound) causes Hypotension (Side Effect)
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Galantamine may lead to a major life threatening interaction when taken with Bupropion