DDInter458 DDInter707
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in rats revealed that it was being localized within enterocytes of the intestinal villi - this prompted studies investigating the effect of ezetimibe on intestinal cholesterol absorption. Ezetimibe is used as an adjunctive therapy to a healthy diet to lower cholesterol levels in primary hyperlipidemia, mixed hyperlipidemia, homozygous familial hypercholesterolemia (HoFH), and homozygous sitosterolemia (phytosterolemia). Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile acids. In genetically NPC1L1-deficient mice, a 70% reduction in intestinal cholesterol absorption was seen, and these mice were insensitive to ezetimibe treatment - it was determined based on these findings that NPC1L1 plays an essential role in promoting intestinal cholesterol uptake via an ezetimibe-sensitive pathway. By interfering with the intestinal uptake of cholesterol and phytosterols, ezetimibe reduces the delivery of intestinal cholesterol to the liver.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) upregulates {v} (Gene) TM9SF3
TM9SF3 {u} (Gene) is downregulated by {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) causes {v} (Side Effect) Malnutrition
Malnutrition {u} (Side Effect) is caused by {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pimozide
Pimozide {u} (Compound) resembles {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Simvastatin
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ezetimibe
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) regulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Ezetimibe
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1B1
SLCO1B1 {u} (Gene) is bound by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ezetimibe
Cyclosporine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Pimozide {u} (Compound) resembles {v} (Compound) Ezetimibe
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ezetimibe (Compound)
Cyclosporine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Ezetimibe (Compound)
Cyclosporine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Ezetimibe (Compound)
Cyclosporine (Compound) upregulates TM9SF3 (Gene) and TM9SF3 (Gene) is downregulated by Ezetimibe (Compound)
Cyclosporine (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Ezetimibe (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pimozide (Compound) and Pimozide (Compound) resembles Ezetimibe (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Simvastatin (Compound) and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Ezetimibe
Cyclosporine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) regulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Ezetimibe (Compound)
Cyclosporine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Rosuvastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Ezetimibe
Cyclosporine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Pimozide (Compound) and Pimozide (Compound) resembles Ezetimibe (Compound)