DDInter1853 DDInter1325
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Tretinoin {u} (Compound) upregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is downregulated by {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) upregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is downregulated by {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) regulates {v} (Gene) SELL
SELL {u} (Gene) is upregulated by {v} (Compound) Ofloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is regulated by {v} (Gene) SLC22A4
SLC22A4 {u} (Gene) is bound by {v} (Compound) Ofloxacin
Tretinoin (Compound) upregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Ofloxacin (Compound)
Tretinoin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Ofloxacin (Compound)
Tretinoin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Ofloxacin (Compound)
Tretinoin (Compound) upregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Tretinoin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Tretinoin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Tretinoin (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Ofloxacin (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Isotretinoin (Compound) upregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Ofloxacin (Compound)
Tretinoin (Compound) upregulates ALAS1 (Gene) and ALAS1 (Gene) regulates SELL (Gene) and SELL (Gene) is upregulated by Ofloxacin (Compound)
Tretinoin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is regulated by SLC22A4 (Gene) and SLC22A4 (Gene) is bound by Ofloxacin (Compound)