DDInter549 DDInter1747
Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. It is approved by the FDA to treat acute and chronic diarrhea. Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination with atropine in the brand mixture Lomotil(R). It works mostly in the periphery and activates opioid receptors in the intestine rather than the central nervous system (CNS). [3] Difenoxin is also closely related to loperamide, but unlike loper
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Difenoxin {u} (Compound) resembles {v} (Compound) Diphenidol
Difenoxin {u} (Compound) resembles {v} (Compound) Methadone
Difenoxin {u} (Compound) binds {v} (Gene) OPRM1
Difenoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Droperidol
Difenoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetrabenazine
Difenoxin (Compound) resembles Diphenidol (Compound)
Difenoxin (Compound) resembles Methadone (Compound)
Difenoxin (Compound) binds OPRM1 (Gene)
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Droperidol
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine