DDInter1943 DDInter178
In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are currently being researched for use in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage. Though this research is so far inconclusive, vitamin E remains a popular supplement and is generally considered safe by the FDA[FDA Label].
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Vitamin E {u} (Compound) resembles {v} (Compound) Phylloquinone
Vitamin E {u} (Compound) binds {v} (Gene) NR1I2
Vitamin E {u} (Compound) upregulates {v} (Gene) CDK6
Vitamin E {u} (Compound) downregulates {v} (Gene) PTPRO
Vitamin E {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mogamulizumab
Vitamin E {u} may cause a minor interaction that can limit clinical effects when taken with {v} Infliximab
Vitamin E {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mechlorethamine
Vitamin E {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eptifibatide
Vitamin E (Compound) resembles Phylloquinone (Compound)
Vitamin E (Compound) binds NR1I2 (Gene)
Vitamin E (Compound) upregulates CDK6 (Gene)
Vitamin E (Compound) downregulates PTPRO (Gene)
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Infliximab
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Eptifibatide