DDInter350 DDInter757
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Fluorouracil
Chlorambucil {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Fluorouracil
Chlorambucil {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Fluorouracil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluorouracil
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) resembles {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Fluorouracil
Chlorambucil {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Fluorouracil
Chlorambucil {u} (Compound) upregulates {v} (Gene) SESN1
SESN1 {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluorouracil
Chlorambucil {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluorouracil
Chlorambucil {u} (Compound) causes {v} (Side Effect) Febrile neutropenia
Febrile neutropenia {u} (Side Effect) is caused by {v} (Compound) Temozolomide
Temozolomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluorouracil
Chlorambucil {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluorouracil
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Fluorouracil (Compound)
Chlorambucil (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Fluorouracil (Compound)
Chlorambucil (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Fluorouracil (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) resembles colon cancer (Disease) and colon cancer (Disease) is treated by Fluorouracil (Compound)
Chlorambucil (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is downregulated by colon cancer (Disease) and CDKN1A (Disease) associated with colon cancer (Gene) and colon cancer (Disease) is treated by Fluorouracil (Compound)
Chlorambucil (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is downregulated by Vinblastine (Compound) and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Fluorouracil
Chlorambucil (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Fluorouracil
Chlorambucil (Compound) causes Febrile neutropenia (Side Effect) and Febrile neutropenia (Side Effect) is caused by Temozolomide (Compound) and Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil
Chlorambucil (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Fluorouracil