DDInter1141 DDInter1789
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Megestrol acetate {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Dydrogesterone
Dydrogesterone {u} (Compound) resembles {v} (Compound) Exemestane
Exemestane {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Dydrogesterone
Dydrogesterone {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) upregulates {v} (Gene) FKBP5
FKBP5 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Fluoxymesterone
Fluoxymesterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Difluprednate
Difluprednate {u} (Compound) causes {v} (Side Effect) Herpes simplex
Herpes simplex {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Ethynodiol
Ethynodiol {u} (Compound) resembles {v} (Compound) Quinestrol
Quinestrol {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) resembles {v} (Compound) Mestranol
Mestranol {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Megestrol acetate {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Megestrol acetate (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may lead to a major life threatening interaction when taken with Thalidomide
Megestrol acetate (Compound) resembles Dydrogesterone (Compound) and Dydrogesterone (Compound) resembles Exemestane (Compound) and Exemestane may lead to a major life threatening interaction when taken with Thalidomide
Megestrol acetate (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Megestrol acetate (Compound) resembles Dydrogesterone (Compound) and Dydrogesterone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may lead to a major life threatening interaction when taken with Thalidomide
Megestrol acetate (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone (Compound) upregulates FKBP5 (Gene) and FKBP5 (Gene) is upregulated by Thalidomide (Compound)
Megestrol acetate (Compound) resembles Fluoxymesterone (Compound) and Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may lead to a major life threatening interaction when taken with Thalidomide
Megestrol acetate (Compound) resembles Difluprednate (Compound) and Difluprednate (Compound) causes Herpes simplex (Side Effect) and Herpes simplex (Side Effect) is caused by Thalidomide (Compound)
Megestrol acetate (Compound) resembles Ethynodiol (Compound) and Ethynodiol (Compound) resembles Quinestrol (Compound) and Quinestrol may lead to a major life threatening interaction when taken with Thalidomide
Megestrol acetate (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) resembles Mestranol (Compound) and Mestranol may lead to a major life threatening interaction when taken with Thalidomide
Megestrol acetate (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Thalidomide (Compound)