DDInter35 DDInter1747
A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Albendazole {u} (Compound) resembles {v} (Compound) Mebendazole
Albendazole {u} (Compound) binds {v} (Gene) ABCB1
Albendazole {u} (Compound) upregulates {v} (Gene) KIF14
Albendazole {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 1A Inducers
Albendazole {u} (Compound) downregulates {v} (Gene) GNPDA1
Albendazole {u} (Compound) causes {v} (Side Effect) Acute hepatic failure
Albendazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Albendazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Albendazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Albendazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nevirapine
Albendazole (Compound) resembles Mebendazole (Compound)
Albendazole (Compound) binds ABCB1 (Gene)
Albendazole (Compound) upregulates KIF14 (Gene)
Albendazole (Compound) is included by Cytochrome P450 1A Inducers (Pharmacologic Class)
Albendazole (Compound) downregulates GNPDA1 (Gene)
Albendazole (Compound) causes Acute hepatic failure (Side Effect)
Albendazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Albendazole may cause a minor interaction that can limit clinical effects when taken with Dexamethasone
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Nevirapine