DDInter513 DDInter556
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis. It was marketed in 1911.
Dexamethasone {u} may lead to a major life threatening interaction when taken with {v} Oxycodone
Oxycodone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Dihydrocodeine
Dexamethasone {u} may lead to a major life threatening interaction when taken with {v} Oxycodone
Oxycodone {u} (Compound) resembles {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} may lead to a major life threatening interaction when taken with {v} Oxycodone
Oxycodone {u} (Compound) resembles {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Dexamethasone may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dihydrocodeine (Compound)
Dexamethasone (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Dihydrocodeine (Compound)
Dexamethasone may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Oxymorphone (Compound) and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound) and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)
Dexamethasone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxymorphone (Compound) and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)