DDInter1874 DDInter150
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Trimethoprim {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) resembles {v} (Compound) Trimetrexate
Trimetrexate {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) resembles {v} (Compound) Papaverine
Papaverine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) binds {v} (Gene) TYMS
TYMS {u} (Gene) is regulated by {v} (Gene) PSRC1
PSRC1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is downregulated by {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) binds {v} (Gene) TYMS
TYMS {u} (Gene) is upregulated by {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Trimethoprim {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Azathioprine
Trimethoprim (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Trimethoprim (Compound) resembles Papaverine (Compound) and Papaverine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Azathioprine (Compound)
Trimethoprim (Compound) resembles Trimetrexate (Compound) and Trimetrexate (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Azathioprine (Compound)
Trimethoprim (Compound) resembles Papaverine (Compound) and Papaverine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Trimethoprim (Compound) resembles Trimethobenzamide (Compound) and Trimethobenzamide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Azathioprine (Compound)
Trimethoprim (Compound) binds TYMS (Gene) and TYMS (Gene) is regulated by PSRC1 (Gene) and PSRC1 (Gene) is downregulated by Azathioprine (Compound)
Trimethoprim (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is downregulated by Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Azathioprine (Compound)
Trimethoprim (Compound) binds TYMS (Gene) and TYMS (Gene) is upregulated by rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Trimethoprim (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Trimethoprim (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is downregulated by ulcerative colitis (Disease) and ABCB1 (Disease) associated with ulcerative colitis (Gene) and ulcerative colitis (Disease) is treated by Azathioprine (Compound)