DDInter385 DDInter534
In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 . Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect . This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy .
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Clomipramine
Clomipramine {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diazepam
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Clomipramine
Clomipramine {u} (Compound) resembles {v} (Compound) Adinazolam
Adinazolam {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Cisapride may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Diazepam (Compound)
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Diazepam (Compound)
Cisapride may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Diazepam (Compound)
Cisapride may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine (Compound) resembles Diazepam (Compound)
Cisapride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diazepam (Compound)
Cisapride may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Adinazolam (Compound) and Adinazolam (Compound) resembles Diazepam (Compound)
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Clobazam (Compound) and Clobazam (Compound) resembles Diazepam (Compound)
Cisapride may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Cisapride may lead to a major life threatening interaction when taken with Amoxapine and Amoxapine (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Cisapride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quazepam (Compound) and Quazepam (Compound) resembles Diazepam (Compound)