DDInter268 DDInter1627
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) upregulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) upregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) upregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is regulated by {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) binds {v} (Gene) VDR
VDR {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) downregulates {v} (Gene) CCL2
CCL2 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) upregulates {v} (Gene) BCL2
BCL2 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcitriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Ergocalciferol {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Calcitriol (Compound) upregulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Calcitriol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Calcitriol (Compound) upregulates TXNRD1 (Gene) and TXNRD1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Calcitriol (Compound) upregulates TXNRD1 (Gene) and TXNRD1 (Gene) is regulated by CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Calcitriol (Compound) binds VDR (Gene) and VDR (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Calcitriol (Compound) downregulates CCL2 (Gene) and CCL2 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Calcitriol (Compound) upregulates BCL2 (Gene) and BCL2 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Calcitriol (Compound) resembles Ergocalciferol (Compound) and Ergocalciferol (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Rufinamide (Compound)