DDInter336 DDInter1724
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for bacterial growth and division, and using them in conjunction helps to slow the development of bacterial resistance. In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts.
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) resembles {v} (Compound) Sulfisoxazole
Sulfisoxazole {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Sulfamerazine
Sulfamerazine {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) resembles {v} (Compound) Sulfanilamide
Sulfanilamide {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Celecoxib {u} (Compound) causes {v} (Side Effect) Meningitis aseptic
Meningitis aseptic {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfamethoxazole
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) resembles Sulfamethoxazole (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Sulfamethoxazole (Compound)
Celecoxib (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Sulfamethoxazole (Compound)
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) resembles Sulfisoxazole (Compound) and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Sulfamerazine (Compound) and Sulfamerazine (Compound) resembles Sulfamethoxazole (Compound)
Celecoxib (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Sulfacetamide (Compound) and Sulfacetamide (Compound) resembles Sulfamethoxazole (Compound)
Celecoxib (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Enzalutamide (Compound) and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Celecoxib (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Toremifene (Compound) and Toremifene may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) resembles Sulfanilamide (Compound) and Sulfanilamide (Compound) resembles Sulfamethoxazole (Compound)
Celecoxib (Compound) causes Meningitis aseptic (Side Effect) and Meningitis aseptic (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole