DDInter298 DDInter461
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts.
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is treated by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Capecitabine
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) downregulates {v} (Gene) INPP1
INPP1 {u} (Gene) is upregulated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Cytarabine
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Cytarabine (Compound)
Carboplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Cytarabine (Compound)
Carboplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cytarabine (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with MYC (Gene) and MYC (Gene) is downregulated by Cytarabine (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Capecitabine (Compound) and Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) downregulates INPP1 (Gene) and INPP1 (Gene) is upregulated by Cytarabine (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cytarabine (Compound)
Carboplatin (Compound) binds MPO (Gene) and MPO (Gene) is downregulated by hematologic cancer (Disease) and MPO (Disease) associated with hematologic cancer (Gene) and hematologic cancer (Disease) is treated by Cytarabine (Compound)