DDInter368 DDInter1763
Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Cholestyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Doxepin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vancomycin
Vancomycin {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Cholestyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Doxepin {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Cholestyramine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Cholestyramine may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Cholestyramine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Cholestyramine may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Cholestyramine may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Temsirolimus (Compound)
Cholestyramine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Cholestyramine may cause a minor interaction that can limit clinical effects when taken with Doxepin and Doxepin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Temsirolimus (Compound)
Cholestyramine may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Temsirolimus (Compound)
Cholestyramine may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Temsirolimus (Compound)
Cholestyramine may cause a minor interaction that can limit clinical effects when taken with Doxepin and Doxepin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Temsirolimus (Compound)