DDInter517 DDInter1397
Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Dexbrompheniramine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dexbrompheniramine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is regulated by {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dexbrompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dexbrompheniramine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dexbrompheniramine {u} (Compound) resembles {v} (Compound) Bepotastine
Bepotastine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Dexbrompheniramine {u} (Compound) resembles {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) upregulates {v} (Gene) TATDN2
TATDN2 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dexbrompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Dexbrompheniramine {u} (Compound) resembles {v} (Compound) Dimetindene
Dimetindene {u} (Compound) binds {v} (Gene) CHRM2
CHRM2 {u} (Gene) is bound by {v} (Compound) Paroxetine
Dexbrompheniramine {u} (Compound) resembles {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Dexbrompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Dexbrompheniramine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Paroxetine (Compound)
Dexbrompheniramine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is regulated by DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Paroxetine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Dexbrompheniramine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Paroxetine (Compound)
Dexbrompheniramine (Compound) resembles Bepotastine (Compound) and Bepotastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Paroxetine (Compound)
Dexbrompheniramine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) upregulates TATDN2 (Gene) and TATDN2 (Gene) is downregulated by Paroxetine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Paroxetine (Compound)
Dexbrompheniramine (Compound) resembles Dimetindene (Compound) and Dimetindene (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Paroxetine (Compound)
Dexbrompheniramine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Paroxetine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Paroxetine (Compound)