DDInter498 DDInter1123
A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.
Demeclocycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Etacrynic acid
Etacrynic acid {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Mannitol
Demeclocycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetazolamide
Acetazolamide {u} (Compound) treats {v} (Disease) glaucoma
glaucoma {u} (Disease) is palliated by {v} (Compound) Mannitol
Demeclocycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Torasemide
Torasemide {u} (Compound) causes {v} (Side Effect) Oropharyngeal discomfort
Oropharyngeal discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Demeclocycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amiloride
Amiloride {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Mannitol
Demeclocycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Mannitol
Demeclocycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Spironolactone
Spironolactone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Demeclocycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium bicarbonate
Sodium bicarbonate {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Mannitol
Demeclocycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbenicillin
Carbenicillin {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Mannitol
Demeclocycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolate mofetil
Mycophenolate mofetil {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Demeclocycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Methotrexate {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Etacrynic acid and Etacrynic acid (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Mannitol (Compound)
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Acetazolamide and Acetazolamide (Compound) treats glaucoma (Disease) and glaucoma (Disease) is palliated by Mannitol (Compound)
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Torasemide and Torasemide (Compound) causes Oropharyngeal discomfort (Side Effect) and Oropharyngeal discomfort (Side Effect) is caused by Mannitol (Compound)
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Amiloride and Amiloride (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Mannitol (Compound)
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Mannitol (Compound)
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Spironolactone and Spironolactone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Sodium bicarbonate and Sodium bicarbonate (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Mannitol (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Carbenicillin and Carbenicillin (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Mannitol (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)