DDInter71 DDInter119
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Aminoglutethimide {u} (Compound) resembles {v} (Compound) Glutethimide
Aminoglutethimide {u} (Compound) binds {v} (Gene) CYP19A1
Aminoglutethimide {u} (Compound) is included by {v} (Pharmacologic Class) Adrenal Steroid Synthesis Inhibitors
Aminoglutethimide {u} (Compound) downregulates {v} (Gene) PSMB8
Aminoglutethimide {u} (Compound) causes {v} (Side Effect) Anaemia
Aminoglutethimide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolbutamide
Aminoglutethimide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Glimepiride
Aminoglutethimide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acalabrutinib
Aminoglutethimide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gefitinib
Aminoglutethimide {u} may lead to a major life threatening interaction when taken with {v} Lumateperone
Aminoglutethimide (Compound) resembles Glutethimide (Compound)
Aminoglutethimide (Compound) binds CYP19A1 (Gene)
Aminoglutethimide (Compound) is included by Adrenal Steroid Synthesis Inhibitors (Pharmacologic Class)
Aminoglutethimide (Compound) downregulates PSMB8 (Gene)
Aminoglutethimide (Compound) causes Anaemia (Side Effect)
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Tolbutamide
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Glimepiride
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib
Aminoglutethimide may lead to a major life threatening interaction when taken with Lumateperone