DDInter1834 DDInter453
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Cyclizine
Topiramate {u} (Compound) causes {v} (Side Effect) Speech disorder
Speech disorder {u} (Side Effect) is caused by {v} (Compound) Cyclizine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Topiramate {u} (Compound) causes {v} (Side Effect) Speech disorder
Speech disorder {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Topiramate {u} (Compound) causes {v} (Side Effect) Altered state of consciousness
Altered state of consciousness {u} (Side Effect) is caused by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Cyclizine
Topiramate {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Topiramate {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Doxapram
Doxapram {u} (Compound) resembles {v} (Compound) Cyclizine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Topiramate {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Nitroglycerin
Nitroglycerin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cyclizine
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Cyclizine (Compound)
Topiramate (Compound) causes Speech disorder (Side Effect) and Speech disorder (Side Effect) is caused by Cyclizine (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Topiramate (Compound) causes Speech disorder (Side Effect) and Speech disorder (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Topiramate (Compound) causes Altered state of consciousness (Side Effect) and Altered state of consciousness (Side Effect) is caused by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Cyclizine (Compound)
Topiramate (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Topiramate (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Doxapram (Compound) and Doxapram (Compound) resembles Cyclizine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Topiramate (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Nitroglycerin (Compound) and Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Cyclizine