DDInter1383 DDInter336
Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular. Pamidronic acid was granted FDA approval on 31 October 1991.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Pamidronic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) resembles {v} (Compound) Clodronate
Clodronate {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) resembles {v} (Compound) Alendronic acid
Alendronic acid {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) resembles {v} (Compound) Clodronate
Clodronate {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) resembles {v} (Compound) Zoledronic acid
Zoledronic acid {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) treats {v} (Disease) osteoporosis
osteoporosis {u} (Disease) resembles {v} (Disease) ankylosing spondylitis
ankylosing spondylitis {u} (Disease) is palliated by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) treats {v} (Disease) Paget's disease of bone
Paget's disease of bone {u} (Disease) resembles {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Celecoxib
Pamidronic acid {u} (Compound) treats {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is associated with {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Pamidronic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cisplatin
Cisplatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Pamidronic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Pamidronic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Pamidronic acid (Compound) resembles Clodronate (Compound) and Clodronate (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Pamidronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Celecoxib (Compound)
Pamidronic acid (Compound) resembles Clodronate (Compound) and Clodronate (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Pamidronic acid (Compound) resembles Zoledronic acid (Compound) and Zoledronic acid (Compound) binds CA12 (Gene) and CA12 (Gene) is bound by Celecoxib (Compound)
Pamidronic acid (Compound) treats osteoporosis (Disease) and osteoporosis (Disease) resembles ankylosing spondylitis (Disease) and ankylosing spondylitis (Disease) is palliated by Celecoxib (Compound)
Pamidronic acid (Compound) treats Paget's disease of bone (Disease) and Paget's disease of bone (Disease) resembles osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Celecoxib (Compound)
Pamidronic acid (Compound) treats osteoporosis (Disease) and osteoporosis (Disease) is associated with CA2 (Gene) and CA2 (Gene) is bound by Celecoxib (Compound)
Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is palliated by Celecoxib (Compound)