DDInter557 DDInter1233
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) regulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) is downregulated by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) IPO13
IPO13 {u} (Gene) regulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) is regulated by {v} (Gene) SERPINA6
SERPINA6 {u} (Gene) is bound by {v} (Compound) Mitotane
Dihydroergotamine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Mitotane (Compound)
Dihydroergotamine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Mitotane (Compound)
Dihydroergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Mitotane (Compound)
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Dihydroergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Mitotane (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) regulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Mitotane (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) is downregulated by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Dihydroergotamine (Compound) downregulates IPO13 (Gene) and IPO13 (Gene) regulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Mitotane (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) is regulated by SERPINA6 (Gene) and SERPINA6 (Gene) is bound by Mitotane (Compound)