DDInter458 DDInter1890
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodendron_ and _Strychnos_. Tubocurarine is a benzylisoquinoline derivative and shares this structural backbone with a number of plant-derived alkaloids, including [morphine] and [papaverine]. It was first isolated by Harold King in 1935 and was used clinically to induce neuromuscular blockade during surgeries, particularly those involving the abdomen. Tubocurarine's clinical use was limited by its relatively long duration of action (30-60 minutes) and a number of significant side effects. Safer and more pharmacokinetically favorable non-depolarizing neuromuscular blockers, such as [rocuronium], have largely replaced the use of tubocurarine in the clinical setting.
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) downregulates {v} (Gene) BACE2
BACE2 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) upregulates {v} (Gene) UFM1
UFM1 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) upregulates {v} (Gene) SESN1
SESN1 {u} (Gene) regulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is regulated by {v} (Gene) BACE2
BACE2 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) downregulates {v} (Gene) BACE2
BACE2 {u} (Gene) regulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) downregulates {v} (Gene) FAM57A
FAM57A {u} (Gene) is regulated by {v} (Gene) LGALS1
LGALS1 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) upregulates {v} (Gene) LARP6
LARP6 {u} (Gene) covaries with {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Tubocurarine
Cyclosporine {u} (Compound) upregulates {v} (Gene) UFM1
UFM1 {u} (Gene) regulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Tubocurarine (Compound)
Cyclosporine (Compound) downregulates BACE2 (Gene) and BACE2 (Gene) is downregulated by Tubocurarine (Compound)
Cyclosporine (Compound) upregulates UFM1 (Gene) and UFM1 (Gene) is downregulated by Tubocurarine (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by SESN1 (Gene) and SESN1 (Gene) is upregulated by Tubocurarine (Compound)
Cyclosporine (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) regulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Tubocurarine (Compound)
Cyclosporine (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is regulated by BACE2 (Gene) and BACE2 (Gene) is downregulated by Tubocurarine (Compound)
Cyclosporine (Compound) downregulates BACE2 (Gene) and BACE2 (Gene) regulates CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Tubocurarine (Compound)
Cyclosporine (Compound) downregulates FAM57A (Gene) and FAM57A (Gene) is regulated by LGALS1 (Gene) and LGALS1 (Gene) is downregulated by Tubocurarine (Compound)
Cyclosporine (Compound) upregulates LARP6 (Gene) and LARP6 (Gene) covaries with ACHE (Gene) and ACHE (Gene) is bound by Tubocurarine (Compound)
Cyclosporine (Compound) upregulates UFM1 (Gene) and UFM1 (Gene) regulates PPP2R3C (Gene) and PPP2R3C (Gene) is downregulated by Tubocurarine (Compound)