DDInter458 DDInter379
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reducing calcium-induced contractions.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) UFM1
UFM1 {u} (Gene) is downregulated by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) causes {v} (Side Effect) Arthritis
Arthritis {u} (Side Effect) is caused by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cilostazol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cilostazol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) UFM1
UFM1 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Cilostazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Cilostazol
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Cilostazol (Compound)
Cyclosporine (Compound) upregulates UFM1 (Gene) and UFM1 (Gene) is downregulated by Cilostazol (Compound)
Cyclosporine (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Chlorpromazine (Compound) and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Cilostazol (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Cilostazol (Compound)
Cyclosporine (Compound) upregulates UFM1 (Gene) and UFM1 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cilostazol (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Cilostazol (Compound)