DDInter1956 DDInter745
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Zalcitabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Fludarabine
Zalcitabine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Fludarabine
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Zalcitabine {u} (Compound) resembles {v} (Compound) Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Zalcitabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Fludarabine
Zalcitabine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Regadenoson
Regadenoson {u} (Compound) resembles {v} (Compound) Fludarabine
Zalcitabine {u} (Compound) causes {v} (Side Effect) Oesophagitis
Oesophagitis {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Zalcitabine {u} (Compound) causes {v} (Side Effect) Flank pain
Flank pain {u} (Side Effect) is caused by {v} (Compound) Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Clofarabine {u} (Compound) resembles {v} (Compound) Fludarabine
Zalcitabine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Floxuridine
Floxuridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Zalcitabine (Compound) binds DCK (Gene) and DCK (Gene) is bound by Fludarabine (Compound)
Zalcitabine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Fludarabine (Compound)
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Zalcitabine (Compound) resembles Cytarabine (Compound) and Cytarabine (Compound) resembles Fludarabine (Compound) and Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Zalcitabine (Compound) binds DCK (Gene) and DCK (Gene) is bound by Nelarabine (Compound) and Nelarabine (Compound) resembles Fludarabine (Compound)
Zalcitabine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Regadenoson (Compound) and Regadenoson (Compound) resembles Fludarabine (Compound)
Zalcitabine (Compound) causes Oesophagitis (Side Effect) and Oesophagitis (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine
Zalcitabine (Compound) causes Flank pain (Side Effect) and Flank pain (Side Effect) is caused by Telbivudine (Compound) and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Zalcitabine (Compound) resembles Emtricitabine (Compound) and Emtricitabine (Compound) resembles Floxuridine (Compound) and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine