DDInter466 DDInter1625
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Rubella virus vaccine is a live attenuated virus vaccine for active immunization against rubella (German measles) that is subcutaneously administered. It is prepared from RA 27/3 strain of live attenuated rubella virus. Rubella is a common childhood disease, caused by rubella virus (togavirus).
Dactinomycin {u} (Compound) treats {v} (Disease) germ cell cancer
Dactinomycin {u} (Compound) binds {v} (Gene) ABCB1
Dactinomycin {u} (Compound) upregulates {v} (Gene) PRR15L
Dactinomycin {u} (Compound) downregulates {v} (Gene) RNPS1
Dactinomycin {u} (Compound) causes {v} (Side Effect) Discomfort
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rilonacept
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anakinra
Dactinomycin {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Dactinomycin (Compound) treats germ cell cancer (Disease)
Dactinomycin (Compound) binds ABCB1 (Gene)
Dactinomycin (Compound) upregulates PRR15L (Gene)
Dactinomycin (Compound) downregulates RNPS1 (Gene)
Dactinomycin (Compound) causes Discomfort (Side Effect)
Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Anakinra
Dactinomycin may lead to a major life threatening interaction when taken with Leflunomide