DDInter1647 DDInter1610
Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analogue, scopolamine can antagonize muscarinic acetylcholine receptors (mAChRs) in the central nervous system and throughout the body, inducing several therapeutic and adverse effects related to alteration of parasympathetic nervous system and cholinergic signalling.[A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981.[A228423,
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyridostigmine
Pyridostigmine {u} (Compound) resembles {v} (Compound) Rivastigmine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tapentadol
Tapentadol {u} (Compound) resembles {v} (Compound) Rivastigmine
Scopolamine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Rivastigmine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyridostigmine
Pyridostigmine {u} (Compound) resembles {v} (Compound) Neostigmine
Neostigmine {u} (Compound) resembles {v} (Compound) Rivastigmine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tapentadol
Tapentadol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Rivastigmine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neostigmine
Neostigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Pyridostigmine {u} (Compound) resembles {v} (Compound) Rivastigmine
Scopolamine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Tapentadol
Tapentadol {u} (Compound) resembles {v} (Compound) Rivastigmine
Scopolamine {u} (Compound) causes {v} (Side Effect) Bradycardia
Bradycardia {u} (Side Effect) is caused by {v} (Compound) Pyridostigmine
Pyridostigmine {u} (Compound) resembles {v} (Compound) Rivastigmine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Hyoscyamine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Rivastigmine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pyridostigmine
Pyridostigmine {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Rivastigmine
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine (Compound) resembles Rivastigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol and Tapentadol (Compound) resembles Rivastigmine (Compound)
Scopolamine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivastigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine (Compound) resembles Neostigmine (Compound) and Neostigmine (Compound) resembles Rivastigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol and Tapentadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Rivastigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Neostigmine and Neostigmine (Compound) resembles Pyridostigmine (Compound) and Pyridostigmine (Compound) resembles Rivastigmine (Compound)
Scopolamine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Tapentadol (Compound) and Tapentadol (Compound) resembles Rivastigmine (Compound)
Scopolamine (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Pyridostigmine (Compound) and Pyridostigmine (Compound) resembles Rivastigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Rivastigmine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Pyridostigmine and Pyridostigmine (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Rivastigmine (Compound)