DDInter1158 DDInter721
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Fenbufen
Fenbufen {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) downregulates {v} (Gene) LAP3
LAP3 {u} (Gene) is downregulated by {v} (Compound) Fenbufen
Fenbufen {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylamide
Salicylamide {u} (Compound) resembles {v} (Compound) Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) upregulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylamide
Salicylamide {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Fenoprofen
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Fenoprofen (Compound)
Mesalazine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Fenoprofen (Compound)
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Fenbufen (Compound) and Fenbufen (Compound) resembles Fenoprofen (Compound)
Mesalazine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Labetalol (Compound) and Labetalol (Compound) resembles Fenoprofen (Compound)
Mesalazine (Compound) downregulates LAP3 (Gene) and LAP3 (Gene) is downregulated by Fenbufen (Compound) and Fenbufen (Compound) resembles Fenoprofen (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Naproxen (Compound) and PTGS2 (Gene) is upregulated by Naproxen (Compound) and Naproxen (Compound) resembles Fenoprofen (Compound)
Mesalazine (Compound) resembles Salicylamide (Compound) and Salicylamide (Compound) resembles Labetalol (Compound) and Labetalol (Compound) resembles Fenoprofen (Compound)
Mesalazine (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Fenoprofen (Compound)
Mesalazine (Compound) upregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Labetalol (Compound) and Labetalol (Compound) resembles Fenoprofen (Compound)
Mesalazine (Compound) resembles Salicylamide (Compound) and Salicylamide (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Fenoprofen (Compound)