DDInter1031 DDInter1686
Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients. Treatment options for chronic Hepatitis C have advanced significantly since 2011, with the development of Direct Acting Antivirals (DAAs) such as ledipasvir. More specifically, ledipasvir is an inhibitor of the Hepatitis C Virus (HCV) Non-Structural Protein 5A (NS5A), which is required for viral RNA replication and assembly of HCV virions. Although its exact mechanism of action is unknown, it is postulated to prevent hyperphosphorylation of NS5A which is required
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
Sodium citrate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Sodium citrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxacin
Sodium citrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neratinib
Sodium citrate {u} may lead to a major life threatening interaction when taken with {v} Aluminum hydroxide
Sodium citrate may cause a minor interaction that can limit clinical effects when taken with Captopril
Sodium citrate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin
Sodium citrate may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Sodium citrate may lead to a major life threatening interaction when taken with Aluminum hydroxide