DDInter149 DDInter1960
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Azatadine {u} (Compound) resembles {v} (Compound) Ketotifen
Azatadine {u} (Compound) resembles {v} (Compound) Alcaftadine
Azatadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Azatadine {u} (Compound) binds {v} (Gene) CYP3A4
Azatadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Azatadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amantadine
Azatadine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Azatadine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Azatadine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Azatadine (Compound) resembles Ketotifen (Compound)
Azatadine (Compound) resembles Alcaftadine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Azatadine (Compound) binds CYP3A4 (Gene)
Azatadine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Amantadine
Azatadine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Azatadine may lead to a major life threatening interaction when taken with Potassium chloride
Azatadine (Compound) resembles Amitriptyline (Compound) and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline