DDInter601 DDInter119
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. Due to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Dronabinol {u} (Compound) resembles {v} (Compound) Nabilone
Dronabinol {u} (Compound) binds {v} (Gene) CNR1
Dronabinol {u} (Compound) is included by {v} (Pharmacologic Class) Cannabinoids
Dronabinol {u} (Compound) causes {v} (Side Effect) Sinusitis
Dronabinol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nifedipine
Dronabinol {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Dronabinol {u} may lead to a major life threatening interaction when taken with {v} Tramadol
Dronabinol (Compound) resembles Nabilone (Compound)
Dronabinol (Compound) binds CNR1 (Gene)
Dronabinol (Compound) is included by Cannabinoids (Pharmacologic Class)
Dronabinol (Compound) causes Sinusitis (Side Effect)
Dronabinol may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine
Dronabinol may lead to a major life threatening interaction when taken with Iohexol
Dronabinol may lead to a major life threatening interaction when taken with Tramadol