DDInter154 DDInter118
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism of alpha-adrenergic and 5-HT2A receptors.[L45859,A4393] Aripiprazole was given FDA approval on November 15, 2002.
Azelastine {u} (Compound) binds {v} (Gene) ADRA1B
ADRA1B {u} (Gene) is bound by {v} (Compound) Aripiprazole
Azelastine {u} (Compound) downregulates {v} (Gene) DERA
DERA {u} (Gene) is downregulated by {v} (Compound) Aripiprazole
Azelastine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Azelastine {u} (Compound) binds {v} (Gene) ADRA1B
ADRA1B {u} (Gene) is bound by {v} (Compound) Nefazodone
Nefazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Azelastine {u} (Compound) binds {v} (Gene) KCNH2
KCNH2 {u} (Gene) is bound by {v} (Compound) Ziprasidone
Ziprasidone {u} (Compound) resembles {v} (Compound) Aripiprazole
Azelastine {u} (Compound) downregulates {v} (Gene) DERA
DERA {u} (Gene) is regulated by {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Aripiprazole
Azelastine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Nefazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Azelastine {u} (Compound) causes {v} (Side Effect) Sneezing
Sneezing {u} (Side Effect) is caused by {v} (Compound) Famotidine
Famotidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Azelastine {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Trazodone
Trazodone {u} (Compound) resembles {v} (Compound) Aripiprazole
Azelastine (Compound) binds ADRA1B (Gene) and ADRA1B (Gene) is bound by Aripiprazole (Compound)
Azelastine (Compound) downregulates DERA (Gene) and DERA (Gene) is downregulated by Aripiprazole (Compound)
Azelastine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Aripiprazole (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Azelastine (Compound) binds ADRA1B (Gene) and ADRA1B (Gene) is bound by Nefazodone (Compound) and Nefazodone (Compound) resembles Aripiprazole (Compound)
Azelastine (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) is bound by Ziprasidone (Compound) and Ziprasidone (Compound) resembles Aripiprazole (Compound)
Azelastine (Compound) downregulates DERA (Gene) and DERA (Gene) is regulated by PCNA (Gene) and PCNA (Gene) is downregulated by Aripiprazole (Compound)
Azelastine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Nefazodone (Compound) and Nefazodone (Compound) resembles Aripiprazole (Compound)
Azelastine (Compound) causes Sneezing (Side Effect) and Sneezing (Side Effect) is caused by Famotidine (Compound) and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Azelastine (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Trazodone (Compound) and Trazodone (Compound) resembles Aripiprazole (Compound)