DDInter856 DDInter470
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the range of 2000-9000. LMWHs have a more predictable response, a greater bioavailability, and a longer anti-Xa half life than unfractionated heparin. Dalteparin can also be safely used in most pregnant women. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Dalteparin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capsicum
Dalteparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinapril
Dalteparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nintedanib
Dalteparin {u} may lead to a major life threatening interaction when taken with {v} Ticlopidine
Dalteparin {u} may lead to a major life threatening interaction when taken with {v} Ponatinib
Dalteparin may cause a minor interaction that can limit clinical effects when taken with Capsicum
Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Quinapril
Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Dalteparin may lead to a major life threatening interaction when taken with Ticlopidine
Dalteparin may lead to a major life threatening interaction when taken with Ponatinib