DDInter1834 DDInter1149
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Topiramate {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Topiramate {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Cyclizine
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Mepenzolate
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Cyclizine
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) regulates {v} (Gene) SGCB
SGCB {u} (Gene) is upregulated by {v} (Compound) Mepenzolate
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Mepenzolate (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Mepenzolate (Compound)
Topiramate (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Mepenzolate (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Topiramate (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Cyclizine (Compound) and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Mepenzolate (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Cyclizine (Compound) and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) regulates SGCB (Gene) and SGCB (Gene) is upregulated by Mepenzolate (Compound)