DDInter195 DDInter336
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Betamethasone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) treats {v} (Disease) ankylosing spondylitis
ankylosing spondylitis {u} (Disease) is palliated by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Betamethasone {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Betamethasone {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) ORM1
ORM1 {u} (Gene) is bound by {v} (Compound) Celecoxib
Betamethasone {u} (Compound) treats {v} (Disease) ankylosing spondylitis
ankylosing spondylitis {u} (Disease) resembles {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Celecoxib
Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Celecoxib (Compound)
Betamethasone (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Celecoxib (Compound)
Betamethasone (Compound) treats ankylosing spondylitis (Disease) and ankylosing spondylitis (Disease) is palliated by Celecoxib (Compound)
Betamethasone (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is palliated by Celecoxib (Compound)
Betamethasone (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is downregulated by Celecoxib (Compound)
Betamethasone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Betamethasone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Etoricoxib (Compound) and PTGS2 (Gene) is upregulated by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Betamethasone (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is regulated by ORM1 (Gene) and ORM1 (Gene) is bound by Celecoxib (Compound)
Betamethasone (Compound) treats ankylosing spondylitis (Disease) and ankylosing spondylitis (Disease) resembles osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Celecoxib (Compound)