DDInter458 DDInter1263
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Buprenorphine
Buprenorphine {u} (Compound) resembles {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is regulated by {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Naltrexone (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Naltrexone (Compound)
Cyclosporine (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Naltrexone (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Naltrexone (Compound)
Cyclosporine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Naltrexone (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Buprenorphine (Compound) and Buprenorphine (Compound) resembles Naltrexone (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is regulated by NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Naltrexone (Compound)
Cyclosporine (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Naltrexone (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Naltrexone (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Naltrexone (Compound)