DDInter154 DDInter411
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse.[FDA Label][L5572,F3763,F3787,F3796]
Azelastine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Azelastine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clonazepam
Azelastine {u} (Compound) causes {v} (Side Effect) Increased appetite
Increased appetite {u} (Side Effect) is caused by {v} (Compound) Clonazepam
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Azelastine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Cloxazolam
Cloxazolam {u} (Compound) resembles {v} (Compound) Clonazepam
Azelastine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nitrazepam
Nitrazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Azelastine {u} (Compound) causes {v} (Side Effect) Increased appetite
Increased appetite {u} (Side Effect) is caused by {v} (Compound) Diazepam
Diazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Azelastine {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Nitrazepam
Nitrazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Azelastine {u} (Compound) causes {v} (Side Effect) Bronchitis
Bronchitis {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clonazepam
Azelastine {u} (Compound) causes {v} (Side Effect) Viral infection
Viral infection {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Azelastine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Clonazepam (Compound)
Azelastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clonazepam (Compound)
Azelastine (Compound) causes Increased appetite (Side Effect) and Increased appetite (Side Effect) is caused by Clonazepam (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam
Azelastine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Cloxazolam (Compound) and Cloxazolam (Compound) resembles Clonazepam (Compound)
Azelastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nitrazepam (Compound) and Nitrazepam (Compound) resembles Clonazepam (Compound)
Azelastine (Compound) causes Increased appetite (Side Effect) and Increased appetite (Side Effect) is caused by Diazepam (Compound) and Diazepam (Compound) resembles Clonazepam (Compound)
Azelastine (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Nitrazepam (Compound) and Nitrazepam (Compound) resembles Clonazepam (Compound)
Azelastine (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Clonazepam
Azelastine (Compound) causes Viral infection (Side Effect) and Viral infection (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam