DDInter781 DDInter832
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Fosinopril {u} (Compound) resembles {v} (Compound) Spirapril
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
Fosinopril {u} (Compound) binds {v} (Gene) SLC15A1
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
Fosinopril {u} (Compound) causes {v} (Side Effect) Urticaria
Fosinopril (Compound) resembles Enalapril (Compound)
Fosinopril (Compound) resembles Spirapril (Compound)
Fosinopril (Compound) treats hypertension (Disease)
Fosinopril (Compound) binds SLC15A1 (Gene)
Fosinopril (Compound) upregulates SYNGR3 (Gene)
Fosinopril (Compound) causes Urticaria (Side Effect)