DDInter458 DDInter293
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Carbamazepine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Carbamazepine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Carbamazepine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Carbamazepine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} (Compound) resembles {v} (Compound) Carbamazepine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Azotaemia
Azotaemia {u} (Side Effect) is caused by {v} (Compound) Clindamycin
Clindamycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Blood triglycerides increased
Blood triglycerides increased {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Carbamazepine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephropathy
Nephropathy {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is palliated by {v} (Compound) Magnesium salicylate
Magnesium salicylate {u} (Compound) resembles {v} (Compound) Carbamazepine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Carbamazepine
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Carbamazepine (Compound)
Cyclosporine (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Carbamazepine (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Phenytoin (Compound) and Phenytoin (Compound) resembles Carbamazepine (Compound)
Cyclosporine (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Modafinil (Compound) and Modafinil (Compound) resembles Carbamazepine (Compound)
Cyclosporine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Cyclosporine (Compound) causes Azotaemia (Side Effect) and Azotaemia (Side Effect) is caused by Clindamycin (Compound) and Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Cyclosporine (Compound) causes Blood triglycerides increased (Side Effect) and Blood triglycerides increased (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Carbamazepine
Cyclosporine (Compound) causes Nephropathy (Side Effect) and Nephropathy (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is palliated by Magnesium salicylate (Compound) and Magnesium salicylate (Compound) resembles Carbamazepine (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Carbamazepine