DDInter537 DDInter1397
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin]. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Diclofenac {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Anaphylactoid reaction {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) resembles {v} (Compound) Clonidine
Clonidine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is regulated by {v} (Gene) FDPS
FDPS {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) resembles {v} (Compound) Nepafenac
Nepafenac {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Diclofenac {u} (Compound) resembles {v} (Compound) Lorazepam
Lorazepam {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Diclofenac (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Paroxetine (Compound)
Diclofenac (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Paroxetine (Compound)
Diclofenac (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Diclofenac (Compound) resembles Clonidine (Compound) and Clonidine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Paroxetine (Compound)
Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is regulated by FDPS (Gene) and FDPS (Gene) is upregulated by Paroxetine (Compound)
Diclofenac (Compound) resembles Nepafenac (Compound) and Nepafenac (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Paroxetine (Compound)
Diclofenac (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Paroxetine (Compound)
Diclofenac (Compound) resembles Lorazepam (Compound) and Lorazepam (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)