DDInter696 DDInter1008
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Ethotoin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) resembles {v} (Compound) Glutethimide
Glutethimide {u} (Compound) binds {v} (Gene) CYP11A1
CYP11A1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) resembles {v} (Compound) Methsuximide
Methsuximide {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is regulated by {v} (Gene) CYP1B1
CYP1B1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) upregulates {v} (Gene) TIAM1
TIAM1 {u} (Gene) is regulated by {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Ethotoin {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Ethotoin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ketoconazole (Compound)
Ethotoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Ketoconazole (Compound)
Ethotoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Ethotoin (Compound) resembles Glutethimide (Compound) and Glutethimide (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) is bound by Ketoconazole (Compound)
Ethotoin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Ethotoin (Compound) resembles Methsuximide (Compound) and Methsuximide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Ketoconazole (Compound)
Ethotoin (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ketoconazole (Compound)
Ethotoin (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is regulated by CYP1B1 (Gene) and CYP1B1 (Gene) is bound by Ketoconazole (Compound)
Ethotoin (Compound) upregulates TIAM1 (Gene) and TIAM1 (Gene) is regulated by INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Ketoconazole (Compound)
Ethotoin (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is bound by Ketoconazole (Compound) and CYP51A1 (Gene) is upregulated by Ketoconazole (Compound)