DDInter453 DDInter1544
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Cyclizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Cyclizine {u} (Compound) resembles {v} (Compound) Trimethaphan
Cyclizine {u} (Compound) binds {v} (Gene) CYP2C9
Cyclizine {u} (Compound) upregulates {v} (Gene) STXBP1
Cyclizine {u} (Compound) downregulates {v} (Gene) TNIP1
Cyclizine {u} (Compound) causes {v} (Side Effect) Hallucinations, mixed
Cyclizine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Cyclizine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Cyclizine (Compound) resembles Ifenprodil (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Cyclizine (Compound) resembles Trimethaphan (Compound)
Cyclizine (Compound) binds CYP2C9 (Gene)
Cyclizine (Compound) upregulates STXBP1 (Gene)
Cyclizine (Compound) downregulates TNIP1 (Gene)
Cyclizine (Compound) causes Hallucinations, mixed (Side Effect)
Cyclizine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Cyclizine may lead to a major life threatening interaction when taken with Zonisamide