DDInter576 DDInter1860
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Triazolam
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Triazolam
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Midazolam
Midazolam {u} (Compound) resembles {v} (Compound) Triazolam
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Flunitrazepam
Flunitrazepam {u} (Compound) resembles {v} (Compound) Triazolam
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is palliated by {v} (Compound) Chlordiazepoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Triazolam
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) GABRG1
GABRG1 {u} (Gene) is bound by {v} (Compound) Triazolam
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Midazolam
Midazolam {u} (Compound) resembles {v} (Compound) Triazolam
Disulfiram {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Alprazolam
Alprazolam {u} (Compound) resembles {v} (Compound) Triazolam
Disulfiram {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Alprazolam
Alprazolam {u} (Compound) resembles {v} (Compound) Triazolam
Disulfiram {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Triazolam
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Triazolam (Compound)
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Triazolam (Compound)
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Midazolam (Compound) and Midazolam (Compound) resembles Triazolam (Compound)
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Flunitrazepam (Compound) and Flunitrazepam (Compound) resembles Triazolam (Compound)
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is palliated by Chlordiazepoxide (Compound) and Chlordiazepoxide (Compound) resembles Triazolam (Compound)
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is associated with GABRG1 (Gene) and GABRG1 (Gene) is bound by Triazolam (Compound)
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Midazolam (Compound) and Midazolam (Compound) resembles Triazolam (Compound)
Disulfiram (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Alprazolam (Compound) and Alprazolam (Compound) resembles Triazolam (Compound)
Disulfiram (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Alprazolam (Compound) and Alprazolam (Compound) resembles Triazolam (Compound)
Disulfiram (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Triazolam (Compound)