DDInter1834 DDInter362
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Chlorpheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Chlorpheniramine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Nasal congestion
Nasal congestion {u} (Side Effect) is caused by {v} (Compound) Pramipexole
Pramipexole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Mitotane
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Topiramate {u} (Compound) binds {v} (Gene) SCN1A
SCN1A {u} (Gene) is bound by {v} (Compound) Ethotoin
Ethotoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is associated with {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is bound by {v} (Compound) Chlorpheniramine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Chlorpheniramine (Compound)
Topiramate (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Chlorpheniramine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Topiramate (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Topiramate (Compound) causes Nasal congestion (Side Effect) and Nasal congestion (Side Effect) is caused by Pramipexole (Compound) and Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Topiramate (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Mitotane (Compound) and Mitotane (Compound) resembles Chlorpheniramine (Compound)
Topiramate (Compound) binds SCN1A (Gene) and SCN1A (Gene) is bound by Ethotoin (Compound) and Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Topiramate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Chlorpheniramine (Compound)
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is associated with SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Chlorpheniramine (Compound)