DDInter154 DDInter1381
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006. It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.[L16168,L37744,L4137,L37749]
Azelastine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Paliperidone
Azelastine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Paliperidone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paliperidone
Azelastine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Risperidone
Risperidone {u} (Compound) resembles {v} (Compound) Paliperidone
Azelastine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Risperidone
Risperidone {u} (Compound) resembles {v} (Compound) Paliperidone
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) is bound by {v} (Compound) Paliperidone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risperidone
Risperidone {u} (Compound) resembles {v} (Compound) Paliperidone
Azelastine {u} (Compound) binds {v} (Gene) ADRA1B
ADRA1B {u} (Gene) interacts with {v} (Gene) ADRA1A
ADRA1A {u} (Gene) is bound by {v} (Compound) Paliperidone
Azelastine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Paliperidone
Azelastine {u} (Compound) causes {v} (Side Effect) Hyperkinesia
Hyperkinesia {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paliperidone
Azelastine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paliperidone (Compound)
Azelastine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Paliperidone (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone
Azelastine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Risperidone (Compound) and Risperidone (Compound) resembles Paliperidone (Compound)
Azelastine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Risperidone (Compound) and Risperidone (Compound) resembles Paliperidone (Compound)
Azelastine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Paliperidone (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Azelastine (Compound) binds ADRA1B (Gene) and ADRA1B (Gene) interacts with ADRA1A (Gene) and ADRA1A (Gene) is bound by Paliperidone (Compound)
Azelastine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Paliperidone
Azelastine (Compound) causes Hyperkinesia (Side Effect) and Hyperkinesia (Side Effect) is caused by Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone