DDInter302 DDInter255
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Carmustine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Carmustine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Busulfan
Carmustine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Carmustine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Carmustine {u} (Compound) treats {v} (Disease) melanoma
melanoma {u} (Disease) is associated with {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Carmustine {u} (Compound) treats {v} (Disease) melanoma
melanoma {u} (Disease) is associated with {v} (Gene) TERT
TERT {u} (Gene) is upregulated by {v} (Compound) Busulfan
Carmustine {u} (Compound) binds {v} (Gene) GSR
GSR {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Carmustine {u} (Compound) treats {v} (Disease) melanoma
melanoma {u} (Disease) upregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Carmustine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Carmustine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) WASF3
WASF3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Carmustine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Carmustine (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Busulfan (Compound)
Carmustine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Carmustine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Carmustine (Compound) treats melanoma (Disease) and melanoma (Disease) is associated with GDF15 (Gene) and GDF15 (Gene) is downregulated by Busulfan (Compound)
Carmustine (Compound) treats melanoma (Disease) and melanoma (Disease) is associated with TERT (Gene) and TERT (Gene) is upregulated by Busulfan (Compound)
Carmustine (Compound) binds GSR (Gene) and GSR (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Carmustine (Compound) treats melanoma (Disease) and melanoma (Disease) upregulates TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Busulfan (Compound)
Carmustine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Carmustine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates WASF3 (Gene) and WASF3 (Gene) is upregulated by Busulfan (Compound)