DDInter458 DDInter1335
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Cyclosporine {u} (Compound) upregulates {v} (Gene) ATF6
ATF6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) downregulates {v} (Gene) DNTTIP2
DNTTIP2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) binds {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) downregulates {v} (Gene) DSCC1
DSCC1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) upregulates {v} (Gene) PSAT1
PSAT1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) upregulates {v} (Gene) ATF6
ATF6 {u} (Gene) is regulated by {v} (Gene) TXNL4B
TXNL4B {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) regulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) FOS
FOS {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) downregulates {v} (Gene) DNTTIP2
DNTTIP2 {u} (Gene) regulates {v} (Gene) ATF6
ATF6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine {u} (Compound) downregulates {v} (Gene) TEX10
TEX10 {u} (Gene) is regulated by {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Cyclosporine (Compound) upregulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) binds FKBP1A (Gene) and FKBP1A (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) downregulates DSCC1 (Gene) and DSCC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) upregulates PSAT1 (Gene) and PSAT1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) upregulates ATF6 (Gene) and ATF6 (Gene) is regulated by TXNL4B (Gene) and TXNL4B (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) regulates CHIC2 (Gene) and CHIC2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) interacts with FOS (Gene) and RRP12 (Gene) is regulated by FOS (Gene) and FOS (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) regulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cyclosporine (Compound) downregulates TEX10 (Gene) and TEX10 (Gene) is regulated by SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)