DDInter158 DDInter1252
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. This regimen can be used in place of the older anti-proliferative [azathioprine] due to its stronger immunosuppressive potency. However, mycophenolic acid treatment is more expensive and requires therapeutic drug monitoring to optimize efficacy and minimize toxicity.[A249180,A249185] Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine. [Mycophenolate mofetil], a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.
Aztreonam {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Aztreonam {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Aztreonam {u} (Compound) resembles {v} (Compound) Cefotaxime
Cefotaxime {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Aztreonam {u} (Compound) resembles {v} (Compound) Ceftizoxime
Ceftizoxime {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Aztreonam {u} (Compound) resembles {v} (Compound) Cefixime
Cefixime {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Aztreonam {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is regulated by {v} (Gene) DUSP6
DUSP6 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Aztreonam {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} (Compound) resembles {v} (Compound) Mycophenolic acid
Aztreonam {u} (Compound) causes {v} (Side Effect) Laryngeal pain
Laryngeal pain {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Aztreonam {u} (Compound) causes {v} (Side Effect) Wheezing
Wheezing {u} (Side Effect) is caused by {v} (Compound) Iron
Iron {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mycophenolic acid
Aztreonam {u} (Compound) causes {v} (Side Effect) Breath odour
Breath odour {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolic acid
Aztreonam (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Mycophenolic acid (Compound)
Aztreonam (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Mycophenolic acid (Compound)
Aztreonam (Compound) resembles Cefotaxime (Compound) and Cefotaxime may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Aztreonam (Compound) resembles Ceftizoxime (Compound) and Ceftizoxime may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Aztreonam (Compound) resembles Cefixime (Compound) and Cefixime may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Aztreonam (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is regulated by DUSP6 (Gene) and DUSP6 (Gene) is upregulated by Mycophenolic acid (Compound)
Aztreonam (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Mycophenolate mofetil (Compound) and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Aztreonam (Compound) causes Laryngeal pain (Side Effect) and Laryngeal pain (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid
Aztreonam (Compound) causes Wheezing (Side Effect) and Wheezing (Side Effect) is caused by Iron (Compound) and Iron may cause a minor interaction that can limit clinical effects when taken with Mycophenolic acid
Aztreonam (Compound) causes Breath odour (Side Effect) and Breath odour (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid