DDInter252 DDInter556
Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. More specifically, bupropion binds to the norepinephrine transporter (NET) and the dopamine transporter (DAT).[A6399,A178810] Bupropion was originally classified as an "atypical" antidepressant because it does not exert the same effects as the classical antidepressants such as Monoamine Oxidase Inhibitors (MA
Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis. It was marketed in 1911.
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Dextromethorphan {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Morphine
Morphine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Diamorphine
Diamorphine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Dihydrocodeine
Bupropion {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Dihydrocodeine
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Bupropion may lead to a major life threatening interaction when taken with Galantamine and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Oxymorphone and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan (Compound) resembles Dihydrocodeine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Morphine and Morphine (Compound) resembles Dihydrocodeine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Diamorphine and Diamorphine (Compound) resembles Dihydrocodeine (Compound)
Bupropion (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dihydrocodeine (Compound)
Bupropion (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Dihydrocodeine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Galantamine and Galantamine (Compound) resembles Hydrocodone (Compound) and Hydrocodone (Compound) resembles Dihydrocodeine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Oxymorphone and Oxymorphone (Compound) resembles Hydrocodone (Compound) and Hydrocodone (Compound) resembles Dihydrocodeine (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Oxymorphone and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)