DDInter336 DDInter1135
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Meclofenamic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Meclofenamic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Meclofenamic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Nocturia
Nocturia {u} (Side Effect) is caused by {v} (Compound) Glimepiride
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Niclosamide
Niclosamide {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Meclofenamic acid (Compound)
Celecoxib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Meclofenamic acid (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Salicylic acid (Compound) and Salicylic acid (Compound) resembles Meclofenamic acid (Compound)
Celecoxib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Salsalate (Compound) and Salsalate (Compound) resembles Meclofenamic acid (Compound)
Celecoxib (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Meclofenamic acid
Celecoxib (Compound) causes Nocturia (Side Effect) and Nocturia (Side Effect) is caused by Glimepiride (Compound) and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Celecoxib (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Salicylic acid (Compound) and Salicylic acid (Compound) resembles Meclofenamic acid (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Niclosamide (Compound) and Niclosamide (Compound) resembles Meclofenamic acid (Compound)