DDInter150 DDInter1657
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. Selinexor, in combination with [bortezomib] and [dexamethasone], is currently approved for the treatment of multiple myeloma, a type of cancer formed from antibody-producing plasma cells.[L7117,L7120,L10145] This condition is typically treated with high dose [bortezomib] and [dexamethasone] chemotherapy followed by an autologous stem-cell transplant. Other chemotherapies for multiple myeloma include [lenalidomide] and [dexamethasone], [thalidomide], and may include [melphalan] if the patient is not eligible for transplant. Selinexor was also granted accelerated approval for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) that have gone through at least 2 lines of systemic therapy. The FDA approved Selinexor in June 2019. The use of selinexor in combination with [bortezomib] and [dexamethasone] was approved by Health Canada in June 2022 for the treatment of multiple myeloma in adult patients who have received at least one prior therapy.
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Azathioprine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
Azathioprine {u} (Compound) binds {v} (Gene) GSTA1
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
Azathioprine {u} (Compound) is included by {v} (Pharmacologic Class) Purines
Azathioprine {u} (Compound) downregulates {v} (Gene) STUB1
Azathioprine {u} (Compound) causes {v} (Side Effect) Hodgkin's disease
Azathioprine (Compound) resembles Adenine (Compound)
Azathioprine (Compound) treats systemic lupus erythematosus (Disease)
Azathioprine (Compound) binds GSTA1 (Gene)
Azathioprine (Compound) upregulates NUCB2 (Gene)
Azathioprine (Compound) is included by Purines (Pharmacologic Class)
Azathioprine (Compound) downregulates STUB1 (Gene)
Azathioprine (Compound) causes Hodgkin's disease (Side Effect)