DDInter1064 DDInter1674
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T<sub>4</sub> (tetraiodothyronine or thyroxine) and T<sub>3</sub> (triiodothyronine or ), resulting in diminished down-stream effects of these hormones. Without sufficient quantities of circulating thyroid hormones, symptoms of hypothyroidism begin to develop such as fatigue, increased heart rate, depression, dry skin and hair, muscle cramps, constipation, weight gain, memory impairment, and poor tolerance to cold temperatures.[F4636,A35722] In response to Thyroid Stimulating Hormone (TSH) release by
Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed. Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
Levothyroxine {u} (Compound) resembles {v} (Compound) Dextrothyroxine
Levothyroxine {u} (Compound) treats {v} (Disease) hypothyroidism
Levothyroxine {u} (Compound) binds {v} (Gene) CYP2C8
Levothyroxine {u} (Compound) upregulates {v} (Gene) AGR2
Levothyroxine {u} (Compound) is included by {v} (Pharmacologic Class) Thyroxine
Levothyroxine {u} (Compound) downregulates {v} (Gene) FHL2
Levothyroxine {u} (Compound) causes {v} (Side Effect) Hypoglycaemia
Levothyroxine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Levothyroxine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoprolol
Levothyroxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentobarbital
Levothyroxine (Compound) resembles Dextrothyroxine (Compound)
Levothyroxine (Compound) treats hypothyroidism (Disease)
Levothyroxine (Compound) binds CYP2C8 (Gene)
Levothyroxine (Compound) upregulates AGR2 (Gene)
Levothyroxine (Compound) is included by Thyroxine (Pharmacologic Class)
Levothyroxine (Compound) downregulates FHL2 (Gene)
Levothyroxine (Compound) causes Hypoglycaemia (Side Effect)
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital