DDInter1870 DDInter1544
Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects. It has largely been replaced by drugs such as [levodopa]. Trihexyphenidyl was granted FDA approval on 13 May 1949.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Trihexyphenidyl {u} (Compound) resembles {v} (Compound) Diphenidol
Trihexyphenidyl {u} (Compound) resembles {v} (Compound) Biperiden
Trihexyphenidyl {u} (Compound) binds {v} (Gene) CHRM1
Trihexyphenidyl {u} (Compound) palliates {v} (Disease) Parkinson's disease
Trihexyphenidyl {u} (Compound) causes {v} (Side Effect) Nervousness
Trihexyphenidyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eluxadoline
Trihexyphenidyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Trihexyphenidyl {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Trihexyphenidyl {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glycopyrronium
Trihexyphenidyl (Compound) resembles Diphenidol (Compound)
Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Trihexyphenidyl (Compound) binds CHRM1 (Gene)
Trihexyphenidyl (Compound) palliates Parkinson's disease (Disease)
Trihexyphenidyl (Compound) causes Nervousness (Side Effect)
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Trihexyphenidyl may lead to a major life threatening interaction when taken with Potassium chloride
Trihexyphenidyl (Compound) resembles Glycopyrronium (Compound) and Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium