DDInter990 DDInter1376
Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Like other organic nitrates, isosorbide mononitrate acts as a prodrug for its active metabolite, [nitric oxide], which mediates the therapeutic action of isosorbide mononitrate. Isosorbide mononitrate has a longer duration of action than [nitroglycerin] due to its slow onset of absorption and metabolism. First approved by the FDA in 1991, isosorbide mononitrate is used for the prevention and management of angina pectoris caused by coronary artery disease; however, the onset
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Isosorbide mononitrate {u} (Compound) resembles {v} (Compound) Isosorbide dinitrate
Isosorbide mononitrate {u} (Compound) binds {v} (Gene) GUCY1B3
Isosorbide mononitrate {u} (Compound) palliates {v} (Disease) coronary artery disease
Isosorbide mononitrate {u} (Compound) is included by {v} (Pharmacologic Class) Vasodilation
Isosorbide mononitrate {u} (Compound) causes {v} (Side Effect) Coagulopathy
Isosorbide mononitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Isosorbide mononitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Isosorbide mononitrate {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Isosorbide mononitrate (Compound) resembles Isosorbide dinitrate (Compound)
Isosorbide mononitrate (Compound) binds GUCY1B3 (Gene)
Isosorbide mononitrate (Compound) palliates coronary artery disease (Disease)
Isosorbide mononitrate (Compound) is included by Vasodilation (Pharmacologic Class)
Isosorbide mononitrate (Compound) causes Coagulopathy (Side Effect)
Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Opium
Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Isosorbide mononitrate may lead to a major life threatening interaction when taken with Nitrous acid