DDInter534 DDInter748
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016. Combining diazepam, a proven effective therapy for acute repetitive seizures
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
Diazepam {u} (Compound) binds {v} (Gene) GABRA5
GABRA5 {u} (Gene) is bound by {v} (Compound) Flumazenil
Diazepam {u} (Compound) causes {v} (Side Effect) Aggression
Aggression {u} (Side Effect) is caused by {v} (Compound) Flumazenil
Diazepam {u} (Compound) resembles {v} (Compound) Clobazam
Clobazam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Diazepam {u} (Compound) resembles {v} (Compound) Midazolam
Midazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Diazepam {u} (Compound) resembles {v} (Compound) Quazepam
Quazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Diazepam {u} (Compound) resembles {v} (Compound) Estazolam
Estazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Diazepam {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Diazepam {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Diazepam {u} (Compound) binds {v} (Gene) GABRA5
GABRA5 {u} (Gene) is bound by {v} (Compound) Midazolam
Midazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Diazepam {u} (Compound) binds {v} (Gene) GABRG2
GABRG2 {u} (Gene) interacts with {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Flumazenil
Diazepam (Compound) binds GABRA5 (Gene) and GABRA5 (Gene) is bound by Flumazenil (Compound)
Diazepam (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Flumazenil (Compound)
Diazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Diazepam (Compound) resembles Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Diazepam (Compound) resembles Quazepam (Compound) and Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Diazepam (Compound) resembles Estazolam (Compound) and Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Diazepam (Compound) resembles Amoxapine (Compound) and Amoxapine may lead to a major life threatening interaction when taken with Flumazenil
Diazepam (Compound) resembles Clomipramine (Compound) and Clomipramine may lead to a major life threatening interaction when taken with Flumazenil
Diazepam (Compound) binds GABRA5 (Gene) and GABRA5 (Gene) is bound by Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Diazepam (Compound) binds GABRG2 (Gene) and GABRG2 (Gene) interacts with GABRA1 (Gene) and GABRA1 (Gene) is bound by Flumazenil (Compound)