DDInter1042 DDInter1662
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
Sertraline {u} (Compound) upregulates {v} (Gene) CYP51A1
Sertraline {u} (Compound) palliates {v} (Disease) schizophrenia
Sertraline {u} (Compound) downregulates {v} (Gene) MRPL19
Sertraline {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Sertraline (Compound) resembles Maprotiline (Compound)
Sertraline (Compound) binds CYP3A4 (Gene)
Sertraline (Compound) upregulates CYP51A1 (Gene)
Sertraline (Compound) palliates schizophrenia (Disease)
Sertraline (Compound) downregulates MRPL19 (Gene)
Sertraline (Compound) causes Anaphylactic shock (Side Effect)