DDInter507 DDInter1662
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH. It has been employed clinically since 1972
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Desmopressin {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Desmopressin {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Desmopressin {u} (Compound) resembles {v} (Compound) Terlipressin
Terlipressin {u} (Compound) causes {v} (Side Effect) Respiratory failure
Respiratory failure {u} (Side Effect) is caused by {v} (Compound) Sertraline
Desmopressin {u} (Compound) resembles {v} (Compound) Gonadorelin
Gonadorelin {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Sertraline
Desmopressin {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) upregulates {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Desmopressin {u} (Compound) resembles {v} (Compound) Pasireotide
Pasireotide {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) autistic disorder
autistic disorder {u} (Disease) is palliated by {v} (Compound) Sertraline
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Desmopressin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Desmopressin (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Desmopressin (Compound) resembles Terlipressin (Compound) and Terlipressin (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Sertraline (Compound)
Desmopressin (Compound) resembles Gonadorelin (Compound) and Gonadorelin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Sertraline (Compound)
Desmopressin (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Sertraline (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Sertraline (Compound)
Desmopressin (Compound) resembles Pasireotide (Compound) and Pasireotide may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with autistic disorder (Disease) and autistic disorder (Disease) is palliated by Sertraline (Compound)