DDInter254 DDInter1376
Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'. First synthesized in 1968 then patented in 1975, it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Buspirone {u} (Compound) binds {v} (Gene) HTR1A
Buspirone {u} (Compound) upregulates {v} (Gene) CGRRF1
Buspirone {u} (Compound) palliates {v} (Disease) panic disorder
Buspirone {u} (Compound) downregulates {v} (Gene) NVL
Buspirone {u} (Compound) causes {v} (Side Effect) Galactorrhoea
Buspirone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Buspirone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amyl Nitrite
Buspirone {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Buspirone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Buspirone (Compound) binds HTR1A (Gene)
Buspirone (Compound) upregulates CGRRF1 (Gene)
Buspirone (Compound) palliates panic disorder (Disease)
Buspirone (Compound) downregulates NVL (Gene)
Buspirone (Compound) causes Galactorrhoea (Side Effect)
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Buspirone may lead to a major life threatening interaction when taken with Dexfenfluramine
Buspirone may lead to a major life threatening interaction when taken with Morphine