DDInter458 DDInter698
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) regulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) regulates {v} (Gene) DHX29
DHX29 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is regulated by {v} (Gene) BAD
BAD {u} (Gene) is downregulated by {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) regulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Etidronic acid
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Etidronic acid (Compound)
Cyclosporine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Etidronic acid (Compound)
Cyclosporine (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Etidronic acid (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) regulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Etidronic acid (Compound)
Cyclosporine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) regulates DHX29 (Gene) and DHX29 (Gene) is upregulated by Etidronic acid (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Etidronic acid (Compound)
Cyclosporine (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is regulated by BAD (Gene) and BAD (Gene) is downregulated by Etidronic acid (Compound)
Cyclosporine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) regulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Etidronic acid (Compound)