DDInter505 DDInter105
Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52. It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients. Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing.
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Desirudin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clove
Desirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venlafaxine
Desirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Selumetinib
Desirudin {u} may lead to a major life threatening interaction when taken with {v} Apixaban
Desirudin {u} may lead to a major life threatening interaction when taken with {v} Betrixaban
Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Desirudin may lead to a major life threatening interaction when taken with Apixaban
Desirudin may lead to a major life threatening interaction when taken with Betrixaban