DDInter1665 DDInter1627
Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Sibutramine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Sibutramine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levetiracetam
Levetiracetam {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetazolamide
Acetazolamide {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levetiracetam
Levetiracetam {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetazolamide
Acetazolamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetazolamide
Acetazolamide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Sibutramine {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Sibutramine {u} (Compound) downregulates {v} (Gene) MIF
MIF {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Sibutramine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Levetiracetam and Levetiracetam (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Acetazolamide and Acetazolamide (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Levetiracetam and Levetiracetam (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Acetazolamide and Acetazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Acetazolamide and Acetazolamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Rufinamide (Compound)
Sibutramine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Sibutramine (Compound) downregulates MIF (Gene) and MIF (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)