DDInter458 DDInter1276
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) upregulates {v} (Gene) AARS
AARS {u} (Gene) is upregulated by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Injury
Injury {u} (Side Effect) is caused by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Indinavir
Indinavir {u} (Compound) resembles {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Saquinavir
Saquinavir {u} (Compound) resembles {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) upregulates {v} (Gene) AARS
AARS {u} (Gene) is regulated by {v} (Gene) CARS
CARS {u} (Gene) is upregulated by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) upregulates {v} (Gene) CARS
CARS {u} (Gene) regulates {v} (Gene) AARS
AARS {u} (Gene) is upregulated by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT3
DDIT3 {u} (Gene) interacts with {v} (Gene) ATF4
ATF4 {u} (Gene) is upregulated by {v} (Compound) Nelfinavir
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) ATF4
ATF4 {u} (Gene) is upregulated by {v} (Compound) Nelfinavir
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Nelfinavir (Compound)
Cyclosporine (Compound) upregulates AARS (Gene) and AARS (Gene) is upregulated by Nelfinavir (Compound)
Cyclosporine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Nelfinavir (Compound)
Cyclosporine (Compound) causes Injury (Side Effect) and Injury (Side Effect) is caused by Nelfinavir (Compound)
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Indinavir (Compound) and Indinavir (Compound) resembles Nelfinavir (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Saquinavir (Compound) and Saquinavir (Compound) resembles Nelfinavir (Compound)
Cyclosporine (Compound) upregulates AARS (Gene) and AARS (Gene) is regulated by CARS (Gene) and CARS (Gene) is upregulated by Nelfinavir (Compound)
Cyclosporine (Compound) upregulates CARS (Gene) and CARS (Gene) regulates AARS (Gene) and AARS (Gene) is upregulated by Nelfinavir (Compound)
Cyclosporine (Compound) upregulates DDIT3 (Gene) and DDIT3 (Gene) interacts with ATF4 (Gene) and ATF4 (Gene) is upregulated by Nelfinavir (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) interacts with ATF4 (Gene) and TRIB3 (Gene) is regulated by ATF4 (Gene) and ATF4 (Gene) is upregulated by Nelfinavir (Compound)