DDInter1055 DDInter904
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Levofloxacin {u} (Compound) downregulates {v} (Gene) HTATSF1
HTATSF1 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Levofloxacin {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Levofloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Idarubicin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Gemifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Gatifloxacin {u} may lead to a major life threatening interaction when taken with {v} Idarubicin
Levofloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} may lead to a major life threatening interaction when taken with {v} Idarubicin
Levofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Levofloxacin {u} (Compound) downregulates {v} (Gene) HTATSF1
HTATSF1 {u} (Gene) is regulated by {v} (Gene) SOX2
SOX2 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Levofloxacin {u} (Compound) downregulates {v} (Gene) DFFA
DFFA {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Levofloxacin {u} (Compound) downregulates {v} (Gene) RB1
RB1 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Idarubicin
Levofloxacin (Compound) downregulates HTATSF1 (Gene) and HTATSF1 (Gene) is upregulated by Idarubicin (Compound)
Levofloxacin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Levofloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Idarubicin
Levofloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Levofloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin may lead to a major life threatening interaction when taken with Idarubicin
Levofloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin may lead to a major life threatening interaction when taken with Idarubicin
Levofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is bound by Idarubicin (Compound) and TOP2A (Gene) is downregulated by Idarubicin (Compound)
Levofloxacin (Compound) downregulates HTATSF1 (Gene) and HTATSF1 (Gene) is regulated by SOX2 (Gene) and SOX2 (Gene) is upregulated by Idarubicin (Compound)
Levofloxacin (Compound) downregulates DFFA (Gene) and DFFA (Gene) is upregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Levofloxacin (Compound) downregulates RB1 (Gene) and RB1 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Idarubicin (Compound)