DDInter1881 DDInter1570
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Ranolazine
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostamatinib
Fostamatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Ranolazine
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Lidocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carvedilol
Carvedilol {u} (Compound) resembles {v} (Compound) Ranolazine
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aprepitant
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ranolazine
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aprepitant
Aprepitant {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Ranolazine
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Lidocaine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ranolazine
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methadone
Methadone {u} (Compound) resembles {v} (Compound) Eprazinone
Eprazinone {u} (Compound) resembles {v} (Compound) Ranolazine
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is upregulated by {v} (Compound) Ranolazine
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benzphetamine
Benzphetamine {u} (Compound) resembles {v} (Compound) Eprazinone
Eprazinone {u} (Compound) resembles {v} (Compound) Ranolazine
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Lidocaine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Ranolazine
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine (Compound) resembles Bupivacaine (Compound) and Bupivacaine (Compound) resembles Ranolazine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Bupivacaine and Bupivacaine (Compound) resembles Ranolazine (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol (Compound) resembles Ranolazine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranolazine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Ranolazine (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ranolazine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Eprazinone (Compound) and Eprazinone (Compound) resembles Ranolazine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Ranolazine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Eprazinone (Compound) and Eprazinone (Compound) resembles Ranolazine (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Ranolazine (Compound)