DDInter1295 DDInter278
Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. Nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Nimodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Nimodipine {u} (Compound) binds {v} (Gene) CACNB3
Nimodipine {u} (Compound) upregulates {v} (Gene) WIF1
Nimodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Nimodipine {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Nimodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Nimodipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nilotinib
Nimodipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bexarotene
Nimodipine {u} may lead to a major life threatening interaction when taken with {v} Clarithromycin
Nimodipine (Compound) resembles Nisoldipine (Compound)
Nimodipine (Compound) binds CACNB3 (Gene)
Nimodipine (Compound) upregulates WIF1 (Gene)
Nimodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Nimodipine (Compound) causes Hyperhidrosis (Side Effect)
Nimodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene
Nimodipine may lead to a major life threatening interaction when taken with Clarithromycin