DDInter1841 DDInter1376
Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and norepinpehrine which activate descending pain inhibitory pathways. Tramadol's effects on serotonin and norepinephrine mimic the effects of other SNRI antidepressants such as [dul
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Tramadol {u} (Compound) resembles {v} (Compound) Venlafaxine
Tramadol {u} (Compound) resembles {v} (Compound) Dextromethorphan
Tramadol {u} (Compound) binds {v} (Gene) SLC6A4
Tramadol {u} (Compound) upregulates {v} (Gene) DNMT1
Tramadol {u} (Compound) palliates {v} (Disease) restless legs syndrome
Tramadol {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Tramadol {u} (Compound) downregulates {v} (Gene) POLR2I
Tramadol {u} (Compound) causes {v} (Side Effect) Asthma
Tramadol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Tramadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Tramadol (Compound) resembles Venlafaxine (Compound)
Tramadol (Compound) resembles Dextromethorphan (Compound)
Tramadol (Compound) binds SLC6A4 (Gene)
Tramadol (Compound) upregulates DNMT1 (Gene)
Tramadol (Compound) palliates restless legs syndrome (Disease)
Tramadol (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Tramadol (Compound) downregulates POLR2I (Gene)
Tramadol (Compound) causes Asthma (Side Effect)
Tramadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline