DDInter1666 DDInter573
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Sildenafil {u} (Compound) binds {v} (Gene) ABCC4
ABCC4 {u} (Gene) is bound by {v} (Compound) Dipyridamole
Sildenafil {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Dipyridamole
Sildenafil {u} (Compound) binds {v} (Gene) ABCC4
ABCC4 {u} (Gene) regulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Dipyridamole
Sildenafil {u} (Compound) binds {v} (Gene) PDE5A
PDE5A {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is palliated by {v} (Compound) Dipyridamole
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) SLC29A1
SLC29A1 {u} (Gene) is bound by {v} (Compound) Dipyridamole
Sildenafil {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Escitalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Sildenafil {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Theophylline
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} (Compound) binds {v} (Gene) PDE10A
PDE10A {u} (Gene) is bound by {v} (Compound) Dipyridamole
Sildenafil {u} (Compound) binds {v} (Gene) ABCC4
ABCC4 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Dipyridamole
Sildenafil (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Dipyridamole (Compound)
Sildenafil (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Dipyridamole (Compound)
Sildenafil (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) regulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Dipyridamole (Compound)
Sildenafil (Compound) binds PDE5A (Gene) and PDE5A (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is palliated by Dipyridamole (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by SLC29A1 (Gene) and SLC29A1 (Gene) is bound by Dipyridamole (Compound)
Sildenafil (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Escitalopram (Compound) and Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Sildenafil (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Theophylline (Compound) and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil (Compound) binds PDE10A (Gene) and PDE10A (Gene) is bound by Dipyridamole (Compound)
Sildenafil (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Dipyridamole (Compound)