DDInter336 DDInter812
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA approval on 21 December 1981.
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Gemfibrozil
Celecoxib {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Gemfibrozil
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemfibrozil
Celecoxib {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemfibrozil
Celecoxib {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemfibrozil
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Gemfibrozil
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemfibrozil
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) regulates {v} (Gene) EZH2
EZH2 {u} (Gene) is upregulated by {v} (Compound) Gemfibrozil
Celecoxib {u} (Compound) causes {v} (Side Effect) Creatine phosphokinase increased
Creatine phosphokinase increased {u} (Side Effect) is caused by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may lead to a major life threatening interaction when taken with {v} Gemfibrozil
Celecoxib {u} (Compound) binds {v} (Gene) MAPK14
MAPK14 {u} (Gene) regulates {v} (Gene) RPN1
RPN1 {u} (Gene) is downregulated by {v} (Compound) Gemfibrozil
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Gemfibrozil (Compound)
Celecoxib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Gemfibrozil (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Celecoxib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Celecoxib (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Gemfibrozil (Compound)
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Gemfibrozil
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) regulates EZH2 (Gene) and EZH2 (Gene) is upregulated by Gemfibrozil (Compound)
Celecoxib (Compound) causes Creatine phosphokinase increased (Side Effect) and Creatine phosphokinase increased (Side Effect) is caused by Rosuvastatin (Compound) and Rosuvastatin may lead to a major life threatening interaction when taken with Gemfibrozil
Celecoxib (Compound) binds MAPK14 (Gene) and MAPK14 (Gene) regulates RPN1 (Gene) and RPN1 (Gene) is downregulated by Gemfibrozil (Compound)