DDInter458 DDInter466
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) BIRC2
BIRC2 {u} (Gene) is downregulated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is regulated by {v} (Gene) PRCP
PRCP {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) regulates {v} (Gene) TCTN1
TCTN1 {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) is regulated by {v} (Gene) SCNN1A
SCNN1A {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) ADGRG1
ADGRG1 {u} (Gene) regulates {v} (Gene) PRR15L
PRR15L {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dactinomycin (Compound)
Cyclosporine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Dactinomycin (Compound)
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dactinomycin (Compound)
Cyclosporine (Compound) upregulates BIRC2 (Gene) and BIRC2 (Gene) is downregulated by Dactinomycin (Compound)
Cyclosporine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Dactinomycin (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is downregulated by kidney cancer (Disease) and ABCB1 (Disease) associated with kidney cancer (Gene) and kidney cancer (Disease) is treated by Dactinomycin (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is regulated by PRCP (Gene) and PRCP (Gene) is upregulated by Dactinomycin (Compound)
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) regulates TCTN1 (Gene) and TCTN1 (Gene) is upregulated by Dactinomycin (Compound)
Cyclosporine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is regulated by SCNN1A (Gene) and SCNN1A (Gene) is upregulated by Dactinomycin (Compound)
Cyclosporine (Compound) upregulates ADGRG1 (Gene) and ADGRG1 (Gene) regulates PRR15L (Gene) and PRR15L (Gene) is upregulated by Dactinomycin (Compound)