DDInter255 DDInter1325
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Busulfan {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Ofloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Ofloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Ofloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is regulated by {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Ofloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Busulfan (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Ofloxacin (Compound)
Busulfan (Compound) downregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Ofloxacin (Compound)
Busulfan (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Ofloxacin (Compound)
Busulfan (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Ofloxacin (Compound)
Busulfan (Compound) downregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Busulfan (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Busulfan (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Ofloxacin (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Ofloxacin
Busulfan (Compound) downregulates FKBP14 (Gene) and FKBP14 (Gene) is regulated by TOP2A (Gene) and TOP2A (Gene) is bound by Ofloxacin (Compound)
Busulfan (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Paclitaxel (Compound) and Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Ofloxacin