DDInter1233 DDInter604
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as drospirenone exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be considered when assessing potential risks of hormonal contraceptive use.
Mitotane {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Mitotane {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) binds {v} (Gene) SERPINA6
SERPINA6 {u} (Gene) is bound by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) binds {v} (Gene) SERPINA6
SERPINA6 {u} (Gene) is bound by {v} (Compound) Medrysone
Medrysone {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Cortisone acetate
Cortisone acetate {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is associated with {v} (Disease) polycystic ovary syndrome
polycystic ovary syndrome {u} (Disease) is palliated by {v} (Compound) Drospirenone
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is downregulated by {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Drospirenone
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Mitotane (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Drospirenone (Compound)
Mitotane (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) binds SERPINA6 (Gene) and SERPINA6 (Gene) is bound by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) binds SERPINA6 (Gene) and SERPINA6 (Gene) is bound by Medrysone (Compound) and Medrysone (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Cortisone acetate (Compound) and Cortisone acetate (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is associated with polycystic ovary syndrome (Disease) and polycystic ovary syndrome (Disease) is palliated by Drospirenone (Compound)
Mitotane (Compound) upregulates ADGRE5 (Gene) and ADGRE5 (Gene) is downregulated by Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Drospirenone (Compound)
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Drospirenone (Compound)