DDInter458 DDInter1717
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a _cytoprotective agent_, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances [A177655, F4519]. Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076].
Cyclosporine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sucralfate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sotalol
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Cyclosporine {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) is regulated by {v} (Gene) FGF2
FGF2 {u} (Gene) is bound by {v} (Compound) Sucralfate
Cyclosporine {u} (Compound) upregulates {v} (Gene) CALU
CALU {u} (Gene) is regulated by {v} (Gene) FGF2
FGF2 {u} (Gene) is bound by {v} (Compound) Sucralfate
Cyclosporine {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) regulates {v} (Gene) EGF
EGF {u} (Gene) is bound by {v} (Compound) Sucralfate
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Digitoxin
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sucralfate
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Pindolol
Pindolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Theophylline
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Enoxacin
Enoxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sucralfate
Cyclosporine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sucralfate (Compound)
Cyclosporine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Cyclosporine (Compound) downregulates COG4 (Gene) and COG4 (Gene) is regulated by FGF2 (Gene) and FGF2 (Gene) is bound by Sucralfate (Compound)
Cyclosporine (Compound) upregulates CALU (Gene) and CALU (Gene) is regulated by FGF2 (Gene) and FGF2 (Gene) is bound by Sucralfate (Compound)
Cyclosporine (Compound) downregulates COG4 (Gene) and COG4 (Gene) regulates EGF (Gene) and EGF (Gene) is bound by Sucralfate (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Thioridazine (Compound) and Thioridazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Digitoxin (Compound) and Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Pindolol (Compound) and Pindolol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Cyclosporine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Theophylline (Compound) and Theophylline may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Enoxacin (Compound) and Enoxacin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate