DDInter1707 DDInter1544
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Spironolactone {u} (Compound) resembles {v} (Compound) Dydrogesterone
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Spironolactone {u} (Compound) treats {v} (Disease) dilated cardiomyopathy
Spironolactone {u} (Compound) binds {v} (Gene) PGR
Spironolactone {u} (Compound) upregulates {v} (Gene) WIF1
Spironolactone {u} (Compound) is included by {v} (Pharmacologic Class) Aldosterone Antagonists
Spironolactone {u} (Compound) downregulates {v} (Gene) GNAS
Spironolactone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Spironolactone (Compound) resembles Testosterone (Compound)
Spironolactone (Compound) resembles Dydrogesterone (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Spironolactone (Compound) treats dilated cardiomyopathy (Disease)
Spironolactone (Compound) binds PGR (Gene)
Spironolactone (Compound) upregulates WIF1 (Gene)
Spironolactone (Compound) is included by Aldosterone Antagonists (Pharmacologic Class)
Spironolactone (Compound) downregulates GNAS (Gene)
Spironolactone (Compound) causes Feeling abnormal (Side Effect)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin