DDInter458 DDInter1470
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Pimozide
Cyclosporine {u} (Compound) upregulates {v} (Gene) GLRX
GLRX {u} (Gene) is upregulated by {v} (Compound) Pimozide
Cyclosporine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is downregulated by {v} (Compound) Pimozide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Pimozide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Domperidone
Domperidone {u} (Compound) resembles {v} (Compound) Pimozide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pimozide
Cyclosporine {u} (Compound) upregulates {v} (Gene) GLRX
GLRX {u} (Gene) is upregulated by {v} (Compound) Fluspirilene
Fluspirilene {u} (Compound) resembles {v} (Compound) Pimozide
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is regulated by {v} (Gene) CALM1
CALM1 {u} (Gene) is bound by {v} (Compound) Pimozide
Cyclosporine {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Ezetimibe
Ezetimibe {u} (Compound) resembles {v} (Compound) Pimozide
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Pimozide (Compound)
Cyclosporine (Compound) upregulates GLRX (Gene) and GLRX (Gene) is upregulated by Pimozide (Compound)
Cyclosporine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregulated by Pimozide (Compound)
Cyclosporine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pimozide (Compound)
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Domperidone (Compound) and Domperidone (Compound) resembles Pimozide (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Cyclosporine (Compound) upregulates GLRX (Gene) and GLRX (Gene) is upregulated by Fluspirilene (Compound) and Fluspirilene (Compound) resembles Pimozide (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Pimozide (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is regulated by CALM1 (Gene) and CALM1 (Gene) is bound by Pimozide (Compound)
Cyclosporine (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Ezetimibe (Compound) and Ezetimibe (Compound) resembles Pimozide (Compound)