DDInter722 DDInter1652
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily. Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Fentanyl {u} (Compound) resembles {v} (Compound) Modafinil
Fentanyl {u} (Compound) resembles {v} (Compound) Aprindine
Fentanyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Fentanyl {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Fentanyl {u} (Compound) palliates {v} (Disease) prostate cancer
Fentanyl {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Fentanyl {u} (Compound) causes {v} (Side Effect) Drug hypersensitivity
Fentanyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Certolizumab pegol
Fentanyl {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Fentanyl {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Fentanyl (Compound) resembles Modafinil (Compound)
Fentanyl (Compound) resembles Aprindine (Compound)
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Fentanyl (Compound) binds CYP3A7-CYP3A51P (Gene)
Fentanyl (Compound) palliates prostate cancer (Disease)
Fentanyl (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Fentanyl (Compound) causes Drug hypersensitivity (Side Effect)
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Fentanyl may lead to a major life threatening interaction when taken with Iohexol
Fentanyl may lead to a major life threatening interaction when taken with Dolasetron