DDInter596 DDInter1175
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is upregulated by {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) regulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) CDKN1B
CDKN1B {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Methotrimeprazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Methotrimeprazine (Compound)
Doxorubicin (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Methotrimeprazine (Compound)
Doxorubicin (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Methotrimeprazine (Compound)
Doxorubicin (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Methotrimeprazine (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methotrimeprazine (Compound)
Doxorubicin (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) regulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Methotrimeprazine (Compound)
Doxorubicin (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Doxorubicin (Compound) downregulates CDKN1B (Gene) and CDKN1B (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Methotrimeprazine (Compound)
Doxorubicin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Thioridazine (Compound) and Thioridazine (Compound) resembles Methotrimeprazine (Compound)