DDInter392 DDInter704
An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Cladribine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cladribine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cladribine {u} (Compound) downregulates {v} (Gene) HMG20B
HMG20B {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cladribine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Everolimus
Cladribine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Cladribine {u} (Compound) binds {v} (Gene) POLE2
POLE2 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Cladribine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Everolimus
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Cladribine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Cladribine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Cladribine (Compound) binds PNP (Gene) and PNP (Gene) is upregulated by Everolimus (Compound)
Cladribine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Everolimus (Compound)
Cladribine (Compound) downregulates HMG20B (Gene) and HMG20B (Gene) is upregulated by Everolimus (Compound)
Cladribine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Everolimus (Compound)
Cladribine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Everolimus (Compound)
Cladribine (Compound) binds POLE2 (Gene) and POLE2 (Gene) is downregulated by Everolimus (Compound)
Cladribine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Everolimus (Compound)
Cladribine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Cladribine (Compound) binds PNP (Gene) and PNP (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)