DDInter255 DDInter1209
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of fungal CYP450 14α-lanosterol demethylase activity.[A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.[A214523, L14021] It is currently available as a variety of prescription and over the counter products. Despite having been in clinical use for an extended period, resistance to miconazole among susceptible organisms is relatively low.
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Miconazole
Busulfan {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Miconazole
Busulfan {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Miconazole
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tioconazole
Tioconazole {u} (Compound) resembles {v} (Compound) Miconazole
Busulfan {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is bound by {v} (Compound) Miconazole
Busulfan {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Escitalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Miconazole
Busulfan {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Oxiconazole
Oxiconazole {u} (Compound) resembles {v} (Compound) Miconazole
Busulfan {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Rifabutin
Rifabutin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Miconazole
Busulfan {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Triclosan
Triclosan {u} (Compound) resembles {v} (Compound) Miconazole
Busulfan {u} (Compound) downregulates {v} (Gene) AARS
AARS {u} (Gene) is upregulated by {v} (Compound) Oxiconazole
Oxiconazole {u} (Compound) resembles {v} (Compound) Miconazole
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound)
Busulfan (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Miconazole (Compound)
Busulfan (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tioconazole (Compound) and Tioconazole (Compound) resembles Miconazole (Compound)
Busulfan (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is bound by Miconazole (Compound)
Busulfan (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Escitalopram (Compound) and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Miconazole
Busulfan (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Oxiconazole (Compound) and Oxiconazole (Compound) resembles Miconazole (Compound)
Busulfan (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Rifabutin (Compound) and Rifabutin may cause a minor interaction that can limit clinical effects when taken with Miconazole
Busulfan (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Triclosan (Compound) and Triclosan (Compound) resembles Miconazole (Compound)
Busulfan (Compound) downregulates AARS (Gene) and AARS (Gene) is upregulated by Oxiconazole (Compound) and Oxiconazole (Compound) resembles Miconazole (Compound)