DDInter1520 DDInter1747
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Primaquine {u} (Compound) resembles {v} (Compound) Chloroquine
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Primaquine {u} (Compound) binds {v} (Gene) SENP8
Primaquine {u} (Compound) downregulates {v} (Gene) PSMB8
Primaquine {u} (Compound) causes {v} (Side Effect) Nausea
Primaquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Romidepsin
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Primaquine (Compound) resembles Chloroquine (Compound)
Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Primaquine (Compound) binds SENP8 (Gene)
Primaquine (Compound) downregulates PSMB8 (Gene)
Primaquine (Compound) causes Nausea (Side Effect)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Primaquine may lead to a major life threatening interaction when taken with Prilocaine