DDInter1744 DDInter1662
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole]. Tamoxifen was granted FDA approval on 30 December 1977.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Tamoxifen {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Tamoxifen {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Tamoxifen {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Sertraline
Tamoxifen {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) DHCR7
DHCR7 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Tamoxifen {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Tamoxifen {u} (Compound) causes {v} (Side Effect) Leukorrhea
Leukorrhea {u} (Side Effect) is caused by {v} (Compound) Sertraline
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Tamoxifen {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Tamoxifen {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) regulates {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Tamoxifen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Tamoxifen (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Sertraline (Compound)
Tamoxifen (Compound) binds EBP (Gene) and EBP (Gene) is upregulated by Sertraline (Compound)
Tamoxifen (Compound) binds DHCR7 (Gene) and Tamoxifen (Compound) upregulates DHCR7 (Gene) and DHCR7 (Gene) is upregulated by Sertraline (Compound)
Tamoxifen (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sertraline (Compound)
Tamoxifen (Compound) causes Leukorrhea (Side Effect) and Leukorrhea (Side Effect) is caused by Sertraline (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Tamoxifen (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) regulates GNPDA1 (Gene) and GNPDA1 (Gene) is upregulated by Sertraline (Compound)