DDInter1123 DDInter1635
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salmeterol was first described in the literature in 1988. Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine. Salmeterol was granted FDA approval on 4 February 1994.
Mannitol {u} (Compound) causes {v} (Side Effect) Ear pain
Ear pain {u} (Side Effect) is caused by {v} (Compound) Salmeterol
Mannitol {u} (Compound) causes {v} (Side Effect) Ear pain
Ear pain {u} (Side Effect) is caused by {v} (Compound) Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salmeterol
Mannitol {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Labetalol
Labetalol {u} may lead to a major life threatening interaction when taken with {v} Salmeterol
Mannitol {u} (Compound) causes {v} (Side Effect) Oral candidiasis
Oral candidiasis {u} (Side Effect) is caused by {v} (Compound) Flunisolide
Flunisolide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Salmeterol
Mannitol {u} (Compound) causes {v} (Side Effect) Pain in extremity
Pain in extremity {u} (Side Effect) is caused by {v} (Compound) Ciclesonide
Ciclesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Salmeterol
Mannitol {u} (Compound) resembles {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Salmeterol
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Amprenavir
Amprenavir {u} may lead to a major life threatening interaction when taken with {v} Salmeterol
Mannitol {u} (Compound) causes {v} (Side Effect) Respiratory tract congestion
Respiratory tract congestion {u} (Side Effect) is caused by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salmeterol
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Timolol
Timolol {u} may lead to a major life threatening interaction when taken with {v} Salmeterol
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Propafenone
Propafenone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salmeterol
Mannitol (Compound) causes Ear pain (Side Effect) and Ear pain (Side Effect) is caused by Salmeterol (Compound)
Mannitol (Compound) causes Ear pain (Side Effect) and Ear pain (Side Effect) is caused by Salbutamol (Compound) and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Mannitol (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Labetalol (Compound) and Labetalol may lead to a major life threatening interaction when taken with Salmeterol
Mannitol (Compound) causes Oral candidiasis (Side Effect) and Oral candidiasis (Side Effect) is caused by Flunisolide (Compound) and Flunisolide may cause a minor interaction that can limit clinical effects when taken with Salmeterol
Mannitol (Compound) causes Pain in extremity (Side Effect) and Pain in extremity (Side Effect) is caused by Ciclesonide (Compound) and Ciclesonide may cause a minor interaction that can limit clinical effects when taken with Salmeterol
Mannitol (Compound) resembles Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Salmeterol (Compound)
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amprenavir (Compound) and Amprenavir may lead to a major life threatening interaction when taken with Salmeterol
Mannitol (Compound) causes Respiratory tract congestion (Side Effect) and Respiratory tract congestion (Side Effect) is caused by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Timolol (Compound) and Timolol may lead to a major life threatening interaction when taken with Salmeterol
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Propafenone (Compound) and Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol