DDInter1619 DDInter1197
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Ropinirole {u} (Compound) binds {v} (Gene) DRD3
DRD3 {u} (Gene) is bound by {v} (Compound) Metoclopramide
Ropinirole {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Ropinirole {u} (Compound) binds {v} (Gene) DRD3
DRD3 {u} (Gene) is bound by {v} (Compound) Dopamine
Dopamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Ropinirole {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Ropinirole {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} (Compound) resembles {v} (Compound) Metoclopramide
Ropinirole {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Procainamide
Procainamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Ropinirole {u} (Compound) causes {v} (Side Effect) Torticollis
Torticollis {u} (Side Effect) is caused by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Ropinirole {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Dopamine
Dopamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Ropinirole {u} (Compound) binds {v} (Gene) DRD3
DRD3 {u} (Gene) is bound by {v} (Compound) Bromocriptine
Bromocriptine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Ropinirole (Compound) binds DRD3 (Gene) and DRD3 (Gene) is bound by Metoclopramide (Compound)
Ropinirole (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Ropinirole (Compound) binds DRD3 (Gene) and DRD3 (Gene) is bound by Dopamine (Compound) and Dopamine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cisapride (Compound) and Cisapride (Compound) resembles Metoclopramide (Compound)
Ropinirole (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)
Ropinirole (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Sunitinib (Compound) and Sunitinib (Compound) resembles Metoclopramide (Compound)
Ropinirole (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Procainamide (Compound) and Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Ropinirole (Compound) causes Torticollis (Side Effect) and Torticollis (Side Effect) is caused by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Ropinirole (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dopamine (Compound) and Dopamine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Ropinirole (Compound) binds DRD3 (Gene) and DRD3 (Gene) is bound by Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide