DDInter458 DDInter679
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vaginal rings, transdermal patches, sprays, gels, and creams.[L11485,L11488,L11491, L11494,L11497,L11500,L11503] When used for oral or IM administration, estradiol is commonly synthesized as a pro-drug ester (such as , , , , and ). Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain. (EE) is a synthetic form of estradiol commonly used as the estrogenic component of most combination oral contraceptive pills (OCPs). Ethinyl estradiol is different from estradiol due to its higher biovailability and increased resistance to metabolism, rendering it more suitable for oral administration.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CSK
CSK {u} (Gene) is upregulated by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) upregulates {v} (Gene) TES
TES {u} (Gene) is downregulated by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) binds {v} (Gene) FKBP4
FKBP4 {u} (Gene) is downregulated by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urine output increased
Urine output increased {u} (Side Effect) is caused by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Estramustine
Estramustine {u} (Compound) resembles {v} (Compound) Estradiol
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Estradiol
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Fulvestrant
Fulvestrant {u} (Compound) resembles {v} (Compound) Estradiol
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Estradiol (Compound)
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Estradiol (Compound)
Cyclosporine (Compound) downregulates CSK (Gene) and CSK (Gene) is upregulated by Estradiol (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Estradiol (Compound)
Cyclosporine (Compound) upregulates TES (Gene) and TES (Gene) is downregulated by Estradiol (Compound)
Cyclosporine (Compound) binds FKBP4 (Gene) and FKBP4 (Gene) is downregulated by Estradiol (Compound)
Cyclosporine (Compound) causes Urine output increased (Side Effect) and Urine output increased (Side Effect) is caused by Estradiol (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Estramustine (Compound) and Estramustine (Compound) resembles Estradiol (Compound)
Cyclosporine (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Estradiol (Compound)
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Fulvestrant (Compound) and Fulvestrant (Compound) resembles Estradiol (Compound)