DDInter265 DDInter1627
The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Calcifediol {u} (Compound) resembles {v} (Compound) Calcipotriol
Calcipotriol {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Calcifediol {u} (Compound) resembles {v} (Compound) Calcitriol
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol {u} may lead to a major life threatening interaction when taken with {v} Paricalcitol
Paricalcitol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol {u} (Compound) resembles {v} (Compound) Calcitriol
Calcitriol {u} (Compound) upregulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol {u} may lead to a major life threatening interaction when taken with {v} Paricalcitol
Paricalcitol {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Calcifediol {u} (Compound) binds {v} (Gene) VDR
VDR {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Calcifediol {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Orlistat
Orlistat {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Calcifediol (Compound) resembles Calcipotriol (Compound) and Calcipotriol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Calcifediol (Compound) resembles Calcitriol (Compound) and Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Calcifediol may lead to a major life threatening interaction when taken with Paricalcitol and Paricalcitol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Calcifediol (Compound) resembles Calcitriol (Compound) and Calcitriol (Compound) upregulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Calcifediol may lead to a major life threatening interaction when taken with Paricalcitol and Paricalcitol (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Calcifediol (Compound) binds VDR (Gene) and VDR (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Calcifediol (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)
Calcifediol (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Calcifediol (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Calcifediol may cause a minor interaction that can limit clinical effects when taken with Orlistat and Orlistat (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)