DDInter458 DDInter1724
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for bacterial growth and division, and using them in conjunction helps to slow the development of bacterial resistance. In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) upregulates {v} (Gene) SLC1A4
SLC1A4 {u} (Gene) is upregulated by {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Purpura
Purpura {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Dapsone
Dapsone {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) upregulates {v} (Gene) SLC1A4
SLC1A4 {u} (Gene) is regulated by {v} (Gene) UGT1A9
UGT1A9 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Purpura
Purpura {u} (Side Effect) is caused by {v} (Compound) Sulfadiazine
Sulfadiazine {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Thrombocytopenic purpura
Thrombocytopenic purpura {u} (Side Effect) is caused by {v} (Compound) Quinine
Quinine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfamethoxazole (Compound)
Cyclosporine (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is upregulated by Sulfamethoxazole (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Sulfamethoxazole (Compound)
Cyclosporine (Compound) causes Purpura (Side Effect) and Purpura (Side Effect) is caused by Sulfamethoxazole (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dapsone (Compound) and Dapsone (Compound) resembles Sulfamethoxazole (Compound)
Cyclosporine (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is regulated by UGT1A9 (Gene) and UGT1A9 (Gene) is bound by Sulfamethoxazole (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Sulfamethoxazole (Compound)
Cyclosporine (Compound) causes Purpura (Side Effect) and Purpura (Side Effect) is caused by Sulfadiazine (Compound) and Sulfadiazine (Compound) resembles Sulfamethoxazole (Compound)
Cyclosporine (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Enzalutamide (Compound) and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Cyclosporine (Compound) causes Thrombocytopenic purpura (Side Effect) and Thrombocytopenic purpura (Side Effect) is caused by Quinine (Compound) and Quinine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole