DDInter363 DDInter927
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Inotuzumab ozogamicin is an antibody-drug conjugate using linker and cytotoxic drug technology similar to that developed for the ground-breaking treatment Mylotarg (), which was approved by the US FDA in 2000 for the treatment of acute myeloid leukaemia. Inotuzumab ozogamicin consists of a recombinant humanised IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide, which is a potent DNA-binding cytotoxic agent . Developed by Pfizer and UCB, inotuzumab ozogamicin was granted approval by EU in June 2017 followed by FDA on August 17th, 2017 for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). ALL is a rapidly progressing cancer of the bone marrow that is associated with high mortality rates and low therapeutic response from standard chemotherapies in relasping conditions. In a randomized trial, inotuzumab ozogamicin displayed higher percentages of patients undergoing longer periods of complete remission with no evidence of disease in comparison to patients receiving alternative chemotherapy .
Chlorpromazine {u} (Compound) resembles {v} (Compound) Prochlorperazine
Chlorpromazine {u} (Compound) resembles {v} (Compound) Ethopropazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Chlorpromazine {u} (Compound) binds {v} (Gene) HTR2C
Chlorpromazine {u} (Compound) upregulates {v} (Gene) AARS
Chlorpromazine {u} (Compound) palliates {v} (Disease) bipolar disorder
Chlorpromazine {u} (Compound) is included by {v} (Pharmacologic Class) Phenothiazines
Chlorpromazine {u} (Compound) downregulates {v} (Gene) EED
Chlorpromazine {u} (Compound) causes {v} (Side Effect) Convulsion
Chlorpromazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Chlorpromazine (Compound) resembles Prochlorperazine (Compound)
Chlorpromazine (Compound) resembles Ethopropazine (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Chlorpromazine (Compound) binds HTR2C (Gene)
Chlorpromazine (Compound) upregulates AARS (Gene)
Chlorpromazine (Compound) palliates bipolar disorder (Disease)
Chlorpromazine (Compound) is included by Phenothiazines (Pharmacologic Class)
Chlorpromazine (Compound) downregulates EED (Gene)
Chlorpromazine (Compound) causes Convulsion (Side Effect)
Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide