DDInter458 DDInter1908
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Valaciclovir (valacyclovir), also known as _Valtrex_, is an antiviral drug that has been used to manage and treat various herpes infections for more than 2 decades. It was initially approved by the FDA in 1995 [FDA label] and marketed by GlaxoSmithKline . Valacyclovir is the L-valine ester of aciclovir. It is a member of the purine (guanine) nucleoside analog drug class . This class of drugs forms an important part of hepatitis, HIV, and cytomegalovirus drug regimens . One major use of valacyclovir is the treatment of genital herpes episodes or outbreaks. Genital herpes is a frequently diagnosed sexually transmitted disease which currently affects more than 400 million individuals worldwide. It is caused by infection with the herpes simplex virus (HSV). Infection with this virus is lifelong with periodic episodes of reactivation .
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ganciclovir
Ganciclovir {u} (Compound) resembles {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) SLC6A14
SLC6A14 {u} (Gene) is bound by {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Ganciclovir
Ganciclovir {u} (Compound) resembles {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Injury
Injury {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Valaciclovir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Thrombotic microangiopathy
Thrombotic microangiopathy {u} (Side Effect) is caused by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valaciclovir
Cyclosporine {u} (Compound) upregulates {v} (Gene) DHDDS
DHDDS {u} (Gene) is upregulated by {v} (Compound) Ganciclovir
Ganciclovir {u} (Compound) resembles {v} (Compound) Valaciclovir
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Valaciclovir
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Valaciclovir (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Valaciclovir (Compound)
Cyclosporine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Valaciclovir (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ganciclovir (Compound) and Ganciclovir (Compound) resembles Valaciclovir (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by SLC6A14 (Gene) and SLC6A14 (Gene) is bound by Valaciclovir (Compound)
Cyclosporine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Ganciclovir (Compound) and Ganciclovir (Compound) resembles Valaciclovir (Compound)
Cyclosporine (Compound) causes Injury (Side Effect) and Injury (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Valaciclovir
Cyclosporine (Compound) causes Thrombotic microangiopathy (Side Effect) and Thrombotic microangiopathy (Side Effect) is caused by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Valaciclovir
Cyclosporine (Compound) upregulates DHDDS (Gene) and DHDDS (Gene) is upregulated by Ganciclovir (Compound) and Ganciclovir (Compound) resembles Valaciclovir (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Valaciclovir