DDInter699 DDInter856
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Etodolac {u} (Compound) binds {v} (Gene) CYP2C9
Etodolac {u} (Compound) upregulates {v} (Gene) SERPINA3
Etodolac {u} (Compound) palliates {v} (Disease) osteoarthritis
Etodolac {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Etodolac {u} (Compound) downregulates {v} (Gene) RAI14
Etodolac {u} (Compound) causes {v} (Side Effect) Rhinitis
Etodolac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Etodolac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nizatidine
Etodolac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anistreplase
Etodolac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sodium sulfate
Etodolac (Compound) binds CYP2C9 (Gene)
Etodolac (Compound) upregulates SERPINA3 (Gene)
Etodolac (Compound) palliates osteoarthritis (Disease)
Etodolac (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Etodolac (Compound) downregulates RAI14 (Gene)
Etodolac (Compound) causes Rhinitis (Side Effect)
Etodolac may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Etodolac may cause a minor interaction that can limit clinical effects when taken with Nizatidine
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate