DDInter1521 DDInter1376
Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Primidone {u} (Compound) resembles {v} (Compound) Phenytoin
Primidone {u} (Compound) treats {v} (Disease) epilepsy syndrome
Primidone {u} (Compound) binds {v} (Gene) CYP2C9
Primidone {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Central Nervous System Disorganized Electrical Activity
Primidone {u} (Compound) downregulates {v} (Gene) OXA1L
Primidone {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Primidone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcifediol
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Primidone (Compound) resembles Phenobarbital (Compound)
Primidone (Compound) resembles Phenytoin (Compound)
Primidone (Compound) treats epilepsy syndrome (Disease)
Primidone (Compound) binds CYP2C9 (Gene)
Primidone (Compound) is included by Decreased Central Nervous System Disorganized Electrical Activity (Pharmacologic Class)
Primidone (Compound) downregulates OXA1L (Gene)
Primidone (Compound) causes Psychotic disorder (Side Effect)
Primidone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Calcifediol
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine