DDInter598 DDInter1853
Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Doxycycline {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tretinoin
Doxycycline {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline {u} (Compound) resembles {v} (Compound) Demeclocycline
Demeclocycline {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Doxycycline {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tetracycline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tretinoin
Doxycycline {u} (Compound) resembles {v} (Compound) Demeclocycline
Demeclocycline {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tetracycline {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Doxycycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tretinoin (Compound)
Doxycycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Doxycycline may lead to a major life threatening interaction when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Doxycycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Doxycycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Acitretin and Acitretin (Compound) resembles Tretinoin (Compound)
Doxycycline (Compound) resembles Tetracycline (Compound) and Tetracycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tretinoin (Compound)
Doxycycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may lead to a major life threatening interaction when taken with Acitretin and Acitretin (Compound) resembles Tretinoin (Compound)
Doxycycline (Compound) resembles Tetracycline (Compound) and Tetracycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)