DDInter908 DDInter1376
Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Iloprost {u} (Compound) resembles {v} (Compound) Bimatoprost
Iloprost {u} (Compound) binds {v} (Gene) PDE4D
Iloprost {u} (Compound) is included by {v} (Pharmacologic Class) Prostaglandins I
Iloprost {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capsicum
Iloprost {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Iloprost {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethaphan
Iloprost {u} may lead to a major life threatening interaction when taken with {v} Betrixaban
Iloprost {u} may lead to a major life threatening interaction when taken with {v} Ibritumomab tiuxetan
Iloprost (Compound) resembles Bimatoprost (Compound)
Iloprost (Compound) binds PDE4D (Gene)
Iloprost (Compound) is included by Prostaglandins I (Pharmacologic Class)
Iloprost may cause a minor interaction that can limit clinical effects when taken with Capsicum
Iloprost may cause a minor interaction that can limit clinical effects when taken with Tadalafil
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Trimethaphan
Iloprost may lead to a major life threatening interaction when taken with Betrixaban
Iloprost may lead to a major life threatening interaction when taken with Ibritumomab tiuxetan