DDInter533 DDInter1174
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Diatrizoate {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Diatrizoate {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Raltitrexed
Raltitrexed {u} (Compound) resembles {v} (Compound) Methotrexate
Diatrizoate {u} (Compound) causes {v} (Side Effect) Haematuria
Haematuria {u} (Side Effect) is caused by {v} (Compound) Lamotrigine
Lamotrigine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methotrexate
Diatrizoate {u} (Compound) causes {v} (Side Effect) Speech impairment NOS
Speech impairment NOS {u} (Side Effect) is caused by {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Diatrizoate {u} (Compound) causes {v} (Side Effect) Paralysis
Paralysis {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Hydroxychloroquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methotrexate
Diatrizoate {u} (Compound) resembles {v} (Compound) Metrizamide
Metrizamide {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Diatrizoate {u} (Compound) causes {v} (Side Effect) Skin necrosis
Skin necrosis {u} (Side Effect) is caused by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Iodipamide {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Methotrexate
Diatrizoate {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iohexol
Iohexol {u} may lead to a major life threatening interaction when taken with {v} Methotrexate
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Iodipamide {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Diatrizoate (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Methotrexate (Compound)
Diatrizoate (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Raltitrexed (Compound) and Raltitrexed (Compound) resembles Methotrexate (Compound)
Diatrizoate (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Lamotrigine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Diatrizoate (Compound) causes Speech impairment NOS (Side Effect) and Speech impairment NOS (Side Effect) is caused by Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Diatrizoate (Compound) causes Paralysis (Side Effect) and Paralysis (Side Effect) is caused by Hydroxychloroquine (Compound) and Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Diatrizoate (Compound) resembles Metrizamide (Compound) and Metrizamide (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is upregulated by Methotrexate (Compound)
Diatrizoate (Compound) causes Skin necrosis (Side Effect) and Skin necrosis (Side Effect) is caused by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Diatrizoate (Compound) resembles Iodipamide (Compound) and Iodipamide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Methotrexate (Compound)
Diatrizoate (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iohexol (Compound) and Iohexol may lead to a major life threatening interaction when taken with Methotrexate
Diatrizoate (Compound) resembles Iodipamide (Compound) and Iodipamide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)