DDInter1531 DDInter119
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, _Plasmodium falciparum_ and _Plasmodium vivax_, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Proguanil {u} (Compound) treats {v} (Disease) malaria
Proguanil {u} (Compound) binds {v} (Gene) CYP3A4
Proguanil {u} (Compound) upregulates {v} (Gene) CNPY3
Proguanil {u} (Compound) is included by {v} (Pharmacologic Class) Dihydrofolate Reductase Inhibitors
Proguanil {u} (Compound) causes {v} (Side Effect) Vomiting
Proguanil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lamotrigine
Proguanil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Brivaracetam
Proguanil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Apalutamide
Proguanil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Proguanil {u} may lead to a major life threatening interaction when taken with {v} Auranofin
Proguanil (Compound) treats malaria (Disease)
Proguanil (Compound) binds CYP3A4 (Gene)
Proguanil (Compound) upregulates CNPY3 (Gene)
Proguanil (Compound) is included by Dihydrofolate Reductase Inhibitors (Pharmacologic Class)
Proguanil (Compound) causes Vomiting (Side Effect)
Proguanil may cause a minor interaction that can limit clinical effects when taken with Lamotrigine
Proguanil may cause a minor interaction that can limit clinical effects when taken with Brivaracetam
Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Proguanil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Proguanil may lead to a major life threatening interaction when taken with Auranofin