DDInter336 DDInter1421
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Celecoxib {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Pentazocine
Celecoxib {u} (Compound) causes {v} (Side Effect) Eosinophilia
Eosinophilia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentazocine
Celecoxib {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Butorphanol
Butorphanol {u} (Compound) resembles {v} (Compound) Pentazocine
Celecoxib {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentazocine
Celecoxib {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Levorphanol
Levorphanol {u} (Compound) resembles {v} (Compound) Pentazocine
Celecoxib {u} (Compound) causes {v} (Side Effect) Ulcer
Ulcer {u} (Side Effect) is caused by {v} (Compound) Naltrexone
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Pentazocine
Celecoxib {u} (Compound) causes {v} (Side Effect) Ulcer
Ulcer {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Pentazocine
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Levorphanol
Levorphanol {u} (Compound) resembles {v} (Compound) Pentazocine
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentazocine
Celecoxib {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) upregulates {v} (Gene) SIGMAR1
SIGMAR1 {u} (Gene) is bound by {v} (Compound) Pentazocine
Celecoxib (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Pentazocine (Compound)
Celecoxib (Compound) causes Eosinophilia (Side Effect) and Eosinophilia (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine
Celecoxib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Butorphanol (Compound) and Butorphanol (Compound) resembles Pentazocine (Compound)
Celecoxib (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine
Celecoxib (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Levorphanol (Compound) and Levorphanol (Compound) resembles Pentazocine (Compound)
Celecoxib (Compound) causes Ulcer (Side Effect) and Ulcer (Side Effect) is caused by Naltrexone (Compound) and Naltrexone may lead to a major life threatening interaction when taken with Pentazocine
Celecoxib (Compound) causes Ulcer (Side Effect) and Ulcer (Side Effect) is caused by Morphine (Compound) and Morphine may lead to a major life threatening interaction when taken with Pentazocine
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Levorphanol (Compound) and Levorphanol (Compound) resembles Pentazocine (Compound)
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is upregulated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine
Celecoxib (Compound) palliates colon cancer (Disease) and colon cancer (Disease) upregulates SIGMAR1 (Gene) and SIGMAR1 (Gene) is bound by Pentazocine (Compound)