DDInter1666 DDInter202
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Sildenafil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bexarotene
Sildenafil {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Sildenafil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Griseofulvin
Griseofulvin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Sildenafil {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Griseofulvin
Griseofulvin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Sildenafil {u} (Compound) causes {v} (Side Effect) Urinary incontinence
Urinary incontinence {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Sildenafil {u} (Compound) causes {v} (Side Effect) Right ventricular failure
Right ventricular failure {u} (Side Effect) is caused by {v} (Compound) Macitentan
Macitentan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bexarotene
Sildenafil {u} (Compound) causes {v} (Side Effect) Vascular anomaly
Vascular anomaly {u} (Side Effect) is caused by {v} (Compound) Valproic acid
Valproic acid {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bexarotene
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Sildenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Sildenafil (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)
Sildenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Griseofulvin (Compound) and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Sildenafil (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Griseofulvin (Compound) and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Sildenafil (Compound) causes Urinary incontinence (Side Effect) and Urinary incontinence (Side Effect) is caused by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Sildenafil (Compound) causes Right ventricular failure (Side Effect) and Right ventricular failure (Side Effect) is caused by Macitentan (Compound) and Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene
Sildenafil (Compound) causes Vascular anomaly (Side Effect) and Vascular anomaly (Side Effect) is caused by Valproic acid (Compound) and Valproic acid may lead to a major life threatening interaction when taken with Bexarotene
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)