DDInter1155 DDInter1747
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Mepyramine {u} (Compound) resembles {v} (Compound) Chloropyramine
Mepyramine {u} (Compound) resembles {v} (Compound) Pheniramine
Mepyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Mepyramine {u} (Compound) binds {v} (Gene) CYP2D6
Mepyramine {u} (Compound) upregulates {v} (Gene) PAK1
Mepyramine {u} (Compound) causes {v} (Side Effect) Skin sensitisation
Mepyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Mepyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Umeclidinium
Mepyramine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Mepyramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Mepyramine (Compound) resembles Chloropyramine (Compound)
Mepyramine (Compound) resembles Pheniramine (Compound)
Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Mepyramine (Compound) binds CYP2D6 (Gene)
Mepyramine (Compound) upregulates PAK1 (Gene)
Mepyramine (Compound) causes Skin sensitisation (Side Effect)
Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Mepyramine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Mepyramine (Compound) resembles Methotrimeprazine (Compound) and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine