DDInter136 DDInter1180
Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products.[A251660,L42840] Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters.[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Atropine is a relatively inexpensive drug and
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Atropine {u} (Compound) resembles {v} (Compound) Cyclopentolate
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Atropine {u} (Compound) binds {v} (Gene) CYP1A2
Atropine {u} (Compound) palliates {v} (Disease) Crohn's disease
Atropine {u} (Compound) is included by {v} (Pharmacologic Class) Cholinergic Muscarinic Antagonists
Atropine {u} (Compound) downregulates {v} (Gene) DLD
Atropine {u} (Compound) causes {v} (Side Effect) Supraventricular extrasystoles
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polythiazide
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Atropine (Compound) resembles Cyclopentolate (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Atropine (Compound) binds CYP1A2 (Gene)
Atropine (Compound) palliates Crohn's disease (Disease)
Atropine (Compound) is included by Cholinergic Muscarinic Antagonists (Pharmacologic Class)
Atropine (Compound) downregulates DLD (Gene)
Atropine (Compound) causes Supraventricular extrasystoles (Side Effect)
Atropine may cause a minor interaction that can limit clinical effects when taken with Polythiazide
Atropine may cause a minor interaction that can limit clinical effects when taken with Digoxin
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine