DDInter1582 DDInter1544
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. The FDA withdrew its approval for the use of all oral dosage form drug products containing more than 1 mg of reserpine.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Reserpine {u} (Compound) resembles {v} (Compound) Rescinnamine
Reserpine {u} (Compound) treats {v} (Disease) hypertension
Reserpine {u} (Compound) binds {v} (Gene) ABCC2
Reserpine {u} (Compound) upregulates {v} (Gene) STX4
Reserpine {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Sympathetic Activity
Reserpine {u} (Compound) downregulates {v} (Gene) TFDP1
Reserpine {u} (Compound) causes {v} (Side Effect) Parkinsonism
Reserpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ephedrine
Reserpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Reserpine {u} may lead to a major life threatening interaction when taken with {v} Cocaine
Reserpine (Compound) resembles Rescinnamine (Compound)
Reserpine (Compound) treats hypertension (Disease)
Reserpine (Compound) binds ABCC2 (Gene)
Reserpine (Compound) upregulates STX4 (Gene)
Reserpine (Compound) is included by Decreased Sympathetic Activity (Pharmacologic Class)
Reserpine (Compound) downregulates TFDP1 (Gene)
Reserpine (Compound) causes Parkinsonism (Side Effect)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Reserpine may lead to a major life threatening interaction when taken with Cocaine