DDInter893 DDInter832
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of [quinacrine] with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.** Hydroxychloroquine was granted FDA approval on 18 April 1955.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Hydroxychloroquine {u} (Compound) resembles {v} (Compound) Chloroquine
Hydroxychloroquine {u} (Compound) resembles {v} (Compound) Amodiaquine
Hydroxychloroquine {u} may lead to a major life threatening interaction when taken with {v} Primaquine
Hydroxychloroquine {u} (Compound) binds {v} (Gene) TLR9
Hydroxychloroquine {u} (Compound) upregulates {v} (Gene) PAK1
Hydroxychloroquine {u} (Compound) downregulates {v} (Gene) TES
Hydroxychloroquine {u} (Compound) causes {v} (Side Effect) Vomiting
Hydroxychloroquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aprepitant
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Hydroxychloroquine (Compound) resembles Chloroquine (Compound)
Hydroxychloroquine (Compound) resembles Amodiaquine (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Hydroxychloroquine (Compound) binds TLR9 (Gene)
Hydroxychloroquine (Compound) upregulates PAK1 (Gene)
Hydroxychloroquine (Compound) downregulates TES (Gene)
Hydroxychloroquine (Compound) causes Vomiting (Side Effect)
Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131