DDInter416 DDInter1747
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Clotrimazole {u} (Compound) resembles {v} (Compound) Diphenidol
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2C9
Clotrimazole {u} (Compound) upregulates {v} (Gene) PCK2
Clotrimazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Clotrimazole {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Clotrimazole (Compound) resembles Methadone (Compound)
Clotrimazole (Compound) resembles Diphenidol (Compound)
Clotrimazole (Compound) binds CYP2C9 (Gene)
Clotrimazole (Compound) upregulates PCK2 (Gene)
Clotrimazole (Compound) is included by Azoles (Pharmacologic Class)
Clotrimazole (Compound) causes Dermatitis bullous (Side Effect)