DDInter940 DDInter1662
Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions. Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phentolamine
Phentolamine {u} (Compound) binds {v} (Gene) SIGMAR1
SIGMAR1 {u} (Gene) is bound by {v} (Compound) Sertraline
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amcinonide
Amcinonide {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phentolamine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Potassium chloride
Potassium chloride {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Sertraline
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amcinonide
Amcinonide {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phentolamine
Phentolamine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Insulin lispro {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Captopril {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Sertraline
Insulin lispro {u} may cause a minor interaction that can limit clinical effects when taken with {v} Potassium chloride
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Insulin lispro {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Insulin lispro {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Histrelin
Histrelin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Phentolamine and Phentolamine (Compound) binds SIGMAR1 (Gene) and SIGMAR1 (Gene) is bound by Sertraline (Compound)
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Sertraline (Compound)
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Phentolamine and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Potassium chloride and Potassium chloride (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Sertraline (Compound)
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Sertraline (Compound)
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Phentolamine and Phentolamine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Sertraline (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Captopril and Captopril (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Sertraline (Compound)
Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Potassium chloride and Potassium chloride may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Captopril and Captopril (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Sertraline (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)