DDInter246 DDInter1658
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Budesonide {u} (Compound) resembles {v} (Compound) Flurandrenolide
Budesonide {u} (Compound) treats {v} (Disease) asthma
Budesonide {u} (Compound) binds {v} (Gene) CYP3A4
Budesonide {u} (Compound) upregulates {v} (Gene) P4HA2
Budesonide {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Budesonide {u} (Compound) downregulates {v} (Gene) RAP1GAP
Budesonide {u} (Compound) causes {v} (Side Effect) Pain
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Isoprenaline
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipilimumab
Budesonide (Compound) resembles Flurandrenolide (Compound)
Budesonide (Compound) treats asthma (Disease)
Budesonide (Compound) binds CYP3A4 (Gene)
Budesonide (Compound) upregulates P4HA2 (Gene)
Budesonide (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Budesonide (Compound) downregulates RAP1GAP (Gene)
Budesonide (Compound) causes Pain (Side Effect)
Budesonide may cause a minor interaction that can limit clinical effects when taken with Isoprenaline
Budesonide may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab