DDInter350 DDInter466
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Chlorambucil {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) DUSP14
DUSP14 {u} (Gene) is downregulated by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dactinomycin
Chlorambucil {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) resembles {v} (Disease) germ cell cancer
germ cell cancer {u} (Disease) is treated by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) regulates {v} (Gene) PRR15L
PRR15L {u} (Gene) is upregulated by {v} (Compound) Dactinomycin
Chlorambucil {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is upregulated by {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Dactinomycin
Chlorambucil (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Dactinomycin (Compound)
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Dactinomycin (Compound)
Chlorambucil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dactinomycin (Compound)
Chlorambucil (Compound) upregulates DUSP14 (Gene) and DUSP14 (Gene) is downregulated by Dactinomycin (Compound)
Chlorambucil (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Dactinomycin (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin
Chlorambucil (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) resembles germ cell cancer (Disease) and germ cell cancer (Disease) is treated by Dactinomycin (Compound)
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Dactinomycin (Compound)
Chlorambucil (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) regulates PRR15L (Gene) and PRR15L (Gene) is upregulated by Dactinomycin (Compound)
Chlorambucil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by kidney cancer (Disease) and kidney cancer (Disease) is treated by Dactinomycin (Compound)