DDInter1881 DDInter534
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 . Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect . This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy .
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midazolam
Midazolam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midazolam
Midazolam {u} (Compound) resembles {v} (Compound) Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midazolam
Midazolam {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fedratinib
Fedratinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Diazepam
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Quazepam (Compound) and Quazepam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Quazepam and Quazepam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Quazepam and Quazepam (Compound) resembles Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) binds ALB (Gene) and ALB (Gene) is bound by Diazepam (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Quazepam and Quazepam (Compound) resembles Diazepam (Compound)