DDInter1123 DDInter65
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Mannitol {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Amifostine
Mannitol {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Doxazosin
Doxazosin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Mannitol {u} (Compound) resembles {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Amifostine
Mannitol {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Amlodipine
Amlodipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Timolol
Timolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Amifostine
Mannitol {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Amiloride
Amiloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Amifostine
Mannitol {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Polythiazide
Polythiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Mannitol (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Amifostine (Compound)
Mannitol (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Doxazosin (Compound) and Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Mannitol (Compound) resembles Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Amifostine (Compound)
Mannitol (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amlodipine (Compound) and Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Timolol (Compound) and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Amifostine (Compound)
Mannitol (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Amiloride (Compound) and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Amifostine (Compound)
Mannitol (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Polythiazide (Compound) and Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Amifostine