DDInter1879 DDInter1397
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Triprolidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) regulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) regulates {v} (Gene) VAPB
VAPB {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is regulated by {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) interacts with {v} (Gene) HDAC5
HDAC5 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) upregulates {v} (Gene) CASP7
CASP7 {u} (Gene) interacts with {v} (Gene) RAD51
RAD51 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) regulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Triprolidine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) regulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Triprolidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Triprolidine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Paroxetine (Compound)
Triprolidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Triprolidine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) regulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Paroxetine (Compound)
Triprolidine (Compound) binds HRH1 (Gene) and HRH1 (Gene) regulates VAPB (Gene) and VAPB (Gene) is downregulated by Paroxetine (Compound)
Triprolidine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is regulated by HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Paroxetine (Compound)
Triprolidine (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) interacts with HDAC5 (Gene) and HDAC5 (Gene) is upregulated by Paroxetine (Compound)
Triprolidine (Compound) upregulates CASP7 (Gene) and CASP7 (Gene) interacts with RAD51 (Gene) and RAD51 (Gene) is downregulated by Paroxetine (Compound)
Triprolidine (Compound) binds HRH1 (Gene) and HRH1 (Gene) regulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Paroxetine (Compound)
Triprolidine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) regulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Paroxetine (Compound)