DDInter350 DDInter178
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
Chlorambucil {u} (Compound) binds {v} (Gene) SLCO1A2
Chlorambucil {u} (Compound) upregulates {v} (Gene) DDB2
Chlorambucil {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Chlorambucil {u} (Compound) downregulates {v} (Gene) CENPA
Chlorambucil {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Chlorambucil (Compound) resembles Melphalan (Compound)
Chlorambucil (Compound) treats ovarian cancer (Disease)
Chlorambucil (Compound) binds SLCO1A2 (Gene)
Chlorambucil (Compound) upregulates DDB2 (Gene)
Chlorambucil (Compound) is included by Alkylating Activity (Pharmacologic Class)
Chlorambucil (Compound) downregulates CENPA (Gene)
Chlorambucil (Compound) causes Hyperuricaemia (Side Effect)