DDInter1938 DDInter1376
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vincristine {u} (Compound) resembles {v} (Compound) Voacamine
Vincristine {u} (Compound) treats {v} (Disease) muscle cancer
Vincristine {u} (Compound) binds {v} (Gene) TUBB
Vincristine {u} (Compound) upregulates {v} (Gene) TICAM1
Vincristine {u} (Compound) is included by {v} (Pharmacologic Class) Vinca Alkaloids
Vincristine {u} (Compound) downregulates {v} (Gene) BRCA1
Vincristine {u} (Compound) causes {v} (Side Effect) Respiratory distress
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB2A
Vincristine (Compound) resembles Vinorelbine (Compound)
Vincristine (Compound) resembles Voacamine (Compound)
Vincristine (Compound) treats muscle cancer (Disease)
Vincristine (Compound) binds TUBB (Gene)
Vincristine (Compound) upregulates TICAM1 (Gene)
Vincristine (Compound) is included by Vinca Alkaloids (Pharmacologic Class)
Vincristine (Compound) downregulates BRCA1 (Gene)
Vincristine (Compound) causes Respiratory distress (Side Effect)
Vincristine (Compound) binds TUBB2A (Gene) and Vincristine (Compound) upregulates TUBB2A (Gene)