DDInter554 DDInter1396
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digitalis_ plant, studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Paromomycin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Neomycin
Neomycin {u} (Compound) resembles {v} (Compound) Paromomycin
Digoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Acarbose {u} (Compound) resembles {v} (Compound) Paromomycin
Digoxin {u} (Compound) downregulates {v} (Gene) PIP4K2B
PIP4K2B {u} (Gene) is upregulated by {v} (Compound) Paromomycin
Digoxin {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Paromomycin
Digoxin {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Paromomycin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Tobramycin
Tobramycin {u} (Compound) resembles {v} (Compound) Paromomycin
Digoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Acarbose {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Paromomycin
Digoxin {u} (Compound) downregulates {v} (Gene) PIP4K2B
PIP4K2B {u} (Gene) regulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Paromomycin
Digoxin {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Paromomycin
Digoxin may cause a minor interaction that can limit clinical effects when taken with Kanamycin and Kanamycin (Compound) resembles Paromomycin (Compound)
Digoxin may cause a minor interaction that can limit clinical effects when taken with Neomycin and Neomycin (Compound) resembles Paromomycin (Compound)
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Paromomycin (Compound)
Digoxin (Compound) downregulates PIP4K2B (Gene) and PIP4K2B (Gene) is upregulated by Paromomycin (Compound)
Digoxin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Paromomycin (Compound)
Digoxin (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Paromomycin (Compound)
Digoxin may cause a minor interaction that can limit clinical effects when taken with Kanamycin and Kanamycin (Compound) resembles Tobramycin (Compound) and Tobramycin (Compound) resembles Paromomycin (Compound)
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Paromomycin (Compound)
Digoxin (Compound) downregulates PIP4K2B (Gene) and PIP4K2B (Gene) regulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Paromomycin (Compound)
Digoxin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Paromomycin (Compound)