DDInter690 DDInter991
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. The first isotretinoin-containing product was FDA approved on 7 May 1982.
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) CYP4A11
CYP4A11 {u} (Gene) is bound by {v} (Compound) Tretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) interacts with {v} (Gene) PRKCD
PRKCD {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) regulates {v} (Gene) TUBA1A
TUBA1A {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Ethanol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Phenytoin (Compound) and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin
Ethanol (Compound) binds CYP4A11 (Gene) and CYP4A11 (Gene) is bound by Tretinoin (Compound) and Tretinoin (Compound) resembles Isotretinoin (Compound)
Ethanol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin
Ethanol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Isotretinoin (Compound)
Ethanol (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Isotretinoin (Compound)
Ethanol (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) interacts with PRKCD (Gene) and PRKCD (Gene) is upregulated by Isotretinoin (Compound)
Ethanol (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) regulates TUBA1A (Gene) and TUBA1A (Gene) is downregulated by Isotretinoin (Compound)
Ethanol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Isotretinoin
Ethanol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Isotretinoin