DDInter535 DDInter125
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Diazoxide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Asenapine
Diazoxide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Asenapine
Diazoxide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) regulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Asenapine
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) interacts with {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Asenapine
Diazoxide {u} (Compound) upregulates {v} (Gene) DDX42
DDX42 {u} (Gene) is regulated by {v} (Gene) ADRA2C
ADRA2C {u} (Gene) is bound by {v} (Compound) Asenapine
Diazoxide {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) regulates {v} (Gene) HTR2B
HTR2B {u} (Gene) is bound by {v} (Compound) Asenapine
Diazoxide {u} (Compound) upregulates {v} (Gene) AGL
AGL {u} (Gene) is regulated by {v} (Gene) IGFBP2
IGFBP2 {u} (Gene) is downregulated by {v} (Compound) Asenapine
Diazoxide {u} (Compound) palliates {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) DRD3
DRD3 {u} (Gene) is bound by {v} (Compound) Asenapine
Diazoxide {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Asenapine
Diazoxide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Asenapine (Compound)
Diazoxide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Asenapine (Compound)
Diazoxide (Compound) binds CA2 (Gene) and CA2 (Gene) regulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Asenapine (Compound)
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) interacts with HTR2A (Gene) and HTR2A (Gene) is bound by Asenapine (Compound)
Diazoxide (Compound) upregulates DDX42 (Gene) and DDX42 (Gene) is regulated by ADRA2C (Gene) and ADRA2C (Gene) is bound by Asenapine (Compound)
Diazoxide (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) regulates HTR2B (Gene) and HTR2B (Gene) is bound by Asenapine (Compound)
Diazoxide (Compound) upregulates AGL (Gene) and AGL (Gene) is regulated by IGFBP2 (Gene) and IGFBP2 (Gene) is downregulated by Asenapine (Compound)
Diazoxide (Compound) palliates hypertension (Disease) and hypertension (Disease) is associated with DRD3 (Gene) and DRD3 (Gene) is bound by Asenapine (Compound)
Diazoxide (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Asenapine (Compound)