DDInter1557 DDInter1676
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Quinine {u} (Compound) resembles {v} (Compound) Quinidine barbiturate
Quinine {u} (Compound) treats {v} (Disease) malaria
Quinine {u} (Compound) binds {v} (Gene) SLC22A4
Quinine {u} (Compound) upregulates {v} (Gene) CPVL
Quinine {u} (Compound) downregulates {v} (Gene) DNAJA3
Quinine {u} (Compound) causes {v} (Side Effect) Optic neuritis
Quinine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Quinine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxycycline
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostemsavir
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aminoglutethimide
Quinine (Compound) resembles Quinidine barbiturate (Compound)
Quinine (Compound) treats malaria (Disease)
Quinine (Compound) binds SLC22A4 (Gene)
Quinine (Compound) upregulates CPVL (Gene)
Quinine (Compound) downregulates DNAJA3 (Gene)
Quinine (Compound) causes Optic neuritis (Side Effect)
Quinine may cause a minor interaction that can limit clinical effects when taken with Modafinil
Quinine may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide