DDInter458 DDInter1383
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular. Pamidronic acid was granted FDA approval on 31 October 1991.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Neoplasm malignant
Neoplasm malignant {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Neoplasm malignant
Neoplasm malignant {u} (Side Effect) is caused by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Pamidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Alendronic acid
Alendronic acid {u} (Compound) resembles {v} (Compound) Pamidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nervousness
Nervousness {u} (Side Effect) is caused by {v} (Compound) Pentamidine
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) SLC25A4
SLC25A4 {u} (Gene) is bound by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Pamidronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephropathy
Nephropathy {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Pamidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Pamidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Pamidronic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) CNPY3
CNPY3 {u} (Gene) is upregulated by {v} (Compound) Alendronic acid
Alendronic acid {u} (Compound) resembles {v} (Compound) Pamidronic acid
Cyclosporine (Compound) causes Neoplasm malignant (Side Effect) and Neoplasm malignant (Side Effect) is caused by Pamidronic acid (Compound)
Cyclosporine (Compound) causes Neoplasm malignant (Side Effect) and Neoplasm malignant (Side Effect) is caused by Clodronate (Compound) and Clodronate (Compound) resembles Pamidronic acid (Compound)
Cyclosporine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Alendronic acid (Compound) and Alendronic acid (Compound) resembles Pamidronic acid (Compound)
Cyclosporine (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Pentamidine (Compound) and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid
Cyclosporine (Compound) downregulates SLC25A4 (Gene) and SLC25A4 (Gene) is bound by Clodronate (Compound) and Clodronate (Compound) resembles Pamidronic acid (Compound)
Cyclosporine (Compound) causes Nephropathy (Side Effect) and Nephropathy (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Pamidronic acid
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Clodronate (Compound) and Clodronate (Compound) resembles Pamidronic acid (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Pamidronic acid
Cyclosporine (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Alendronic acid (Compound) and Alendronic acid (Compound) resembles Pamidronic acid (Compound)