DDInter1704 DDInter1376
Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.[Label,L6373,L6376]
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Sotalol {u} (Compound) resembles {v} (Compound) Atenolol
Sotalol {u} (Compound) binds {v} (Gene) ADRB1
Sotalol {u} (Compound) is included by {v} (Pharmacologic Class) Cardiac Rhythm Alteration
Sotalol {u} (Compound) causes {v} (Side Effect) Ache
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin degludec
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Sotalol {u} may lead to a major life threatening interaction when taken with {v} Picosulfuric acid
Sotalol {u} may lead to a major life threatening interaction when taken with {v} Terfenadine
Sotalol (Compound) resembles Atenolol (Compound)
Sotalol (Compound) binds ADRB1 (Gene)
Sotalol (Compound) is included by Cardiac Rhythm Alteration (Pharmacologic Class)
Sotalol (Compound) causes Ache (Side Effect)
Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Sotalol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Sotalol may lead to a major life threatening interaction when taken with Picosulfuric acid
Sotalol may lead to a major life threatening interaction when taken with Terfenadine