DDInter1478 DDInter856
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Piroxicam {u} (Compound) resembles {v} (Compound) Meloxicam
Piroxicam {u} (Compound) binds {v} (Gene) ALB
Piroxicam {u} (Compound) palliates {v} (Disease) osteoarthritis
Piroxicam {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Piroxicam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Famotidine
Piroxicam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Piroxicam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Piroxicam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desmopressin
Piroxicam {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Piroxicam {u} may lead to a major life threatening interaction when taken with {v} Ibritumomab tiuxetan
Piroxicam (Compound) resembles Meloxicam (Compound)
Piroxicam (Compound) binds ALB (Gene)
Piroxicam (Compound) palliates osteoarthritis (Disease)
Piroxicam (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Piroxicam may cause a minor interaction that can limit clinical effects when taken with Famotidine
Piroxicam may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin
Piroxicam may lead to a major life threatening interaction when taken with Iohexol
Piroxicam may lead to a major life threatening interaction when taken with Ibritumomab tiuxetan