DDInter458 DDInter883
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) GMNN
GMNN {u} (Gene) is downregulated by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB1
TRIB1 {u} (Gene) is downregulated by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mood swings
Mood swings {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) regulates {v} (Gene) WIF1
WIF1 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) GMNN
GMNN {u} (Gene) regulates {v} (Gene) ABL1
ABL1 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Hydrochlorothiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is regulated by {v} (Gene) CCDC92
CCDC92 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) downregulates GMNN (Gene) and GMNN (Gene) is downregulated by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) upregulates TRIB1 (Gene) and TRIB1 (Gene) is downregulated by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) causes Mood swings (Side Effect) and Mood swings (Side Effect) is caused by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Hydrochlorothiazide (Compound)
Cyclosporine (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) regulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) downregulates GMNN (Gene) and GMNN (Gene) regulates ABL1 (Gene) and ABL1 (Gene) is upregulated by Hydrochlorothiazide (Compound)
Cyclosporine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Hydrochlorothiazide (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is regulated by CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Hydrochlorothiazide (Compound)