DDInter1864 DDInter442
Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease, TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and tolerant to [penicillamine]. TETA has been investigated in clinical trials for the treatment of heart failure in patients with diabetes.[A18804,A19332,A19333,A19334,A19335]
Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color. It is prepared by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. According to the good manufacturing or feeding practice by the FDA, copper gluconate is used as a nutrient or dietary supplement and is generally recognized as safe for use at a level not exceeding 0.005 percent.
Triethylenetetramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zinc gluconate
Triethylenetetramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcium gluconate
Triethylenetetramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium oxide
Triethylenetetramine may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Triethylenetetramine may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Triethylenetetramine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide