DDInter336 DDInter1095
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or [hydrochlorothiazide]. Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide.[L7423,L7426] Patients taking losartan should have their renal function and potassium levels monitored. Losartan was granted FDA approval on 14 April 1995.
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Losartan
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Losartan
Celecoxib {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Losartan
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Valsartan
Valsartan {u} (Compound) resembles {v} (Compound) Losartan
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Losartan
Celecoxib {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) regulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is upregulated by {v} (Compound) Losartan
Celecoxib {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Losartan
Celecoxib {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Valsartan
Valsartan {u} (Compound) resembles {v} (Compound) Losartan
Celecoxib {u} (Compound) causes {v} (Side Effect) Angina pectoris
Angina pectoris {u} (Side Effect) is caused by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Losartan
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Losartan
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Losartan (Compound)
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Losartan (Compound)
Celecoxib (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Losartan (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Valsartan (Compound) and Valsartan (Compound) resembles Losartan (Compound)
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Candesartan (Compound) and Candesartan (Compound) resembles Losartan (Compound)
Celecoxib (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) regulates ADRB2 (Gene) and ADRB2 (Gene) is upregulated by Losartan (Compound)
Celecoxib (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Losartan
Celecoxib (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Valsartan (Compound) and Valsartan (Compound) resembles Losartan (Compound)
Celecoxib (Compound) causes Angina pectoris (Side Effect) and Angina pectoris (Side Effect) is caused by Candesartan (Compound) and Candesartan (Compound) resembles Losartan (Compound)
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Losartan (Compound)