DDInter535 DDInter1778
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Diazoxide {u} (Compound) downregulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is upregulated by {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is downregulated by {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) downregulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) regulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is regulated by {v} (Gene) CBR1
CBR1 {u} (Gene) is bound by {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) downregulates {v} (Gene) TIMP1
TIMP1 {u} (Gene) regulates {v} (Gene) CBR1
CBR1 {u} (Gene) is bound by {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} (Compound) resembles {v} (Compound) Tetrabenazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetrabenazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Extrapyramidal symptoms
Extrapyramidal symptoms {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetrabenazine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Diazoxide (Compound) downregulates HPRT1 (Gene) and HPRT1 (Gene) is upregulated by Tetrabenazine (Compound)
Diazoxide (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Tetrabenazine (Compound)
Diazoxide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Tetrabenazine (Compound)
Diazoxide (Compound) downregulates HPRT1 (Gene) and HPRT1 (Gene) regulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Tetrabenazine (Compound)
Diazoxide (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is regulated by CBR1 (Gene) and CBR1 (Gene) is bound by Tetrabenazine (Compound)
Diazoxide (Compound) downregulates TIMP1 (Gene) and TIMP1 (Gene) regulates CBR1 (Gene) and CBR1 (Gene) is bound by Tetrabenazine (Compound)
Diazoxide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Donepezil (Compound) and Donepezil (Compound) resembles Tetrabenazine (Compound)
Diazoxide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tetrabenazine
Diazoxide (Compound) causes Extrapyramidal symptoms (Side Effect) and Extrapyramidal symptoms (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Tetrabenazine (Compound)