DDInter780 DDInter1197
Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by _Streptomyces fradiae_.[A229338,A230348] It may also be produced synthetically and is commercially available as the disodium salt for intravenous administration and as the calcium or trometamol salt for oral administration. In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring. Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated urinary tract infections (UTIs) in females. Despite being FDA approved only for urinary tract infections, fosfomycin actually has a broad spectrum of activity and is active against both gram-positive and gram-negative bacteria. As such there is great interest in
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Fosfomycin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} (Compound) resembles {v} (Compound) Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Asthma
Asthma {u} (Side Effect) is caused by {v} (Compound) Acetaminophen
Acetaminophen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Phosphatase alkaline increased
Phosphatase alkaline increased {u} (Side Effect) is caused by {v} (Compound) Zolpidem
Zolpidem {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Nervousness
Nervousness {u} (Side Effect) is caused by {v} (Compound) Desvenlafaxine
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Platelet count decreased
Platelet count decreased {u} (Side Effect) is caused by {v} (Compound) Tramadol
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Paliperidone
Paliperidone {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Fosfomycin {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Amisulpride
Amisulpride {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Fosfomycin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Fosfomycin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)
Fosfomycin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Sunitinib (Compound) and Sunitinib (Compound) resembles Metoclopramide (Compound)
Fosfomycin (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Acetaminophen (Compound) and Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Fosfomycin (Compound) causes Phosphatase alkaline increased (Side Effect) and Phosphatase alkaline increased (Side Effect) is caused by Zolpidem (Compound) and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Fosfomycin (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Desvenlafaxine (Compound) and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Fosfomycin (Compound) causes Platelet count decreased (Side Effect) and Platelet count decreased (Side Effect) is caused by Tramadol (Compound) and Tramadol may lead to a major life threatening interaction when taken with Metoclopramide
Fosfomycin (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Paliperidone (Compound) and Paliperidone may lead to a major life threatening interaction when taken with Metoclopramide
Fosfomycin (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Amisulpride (Compound) and Amisulpride (Compound) resembles Metoclopramide (Compound) and Amisulpride may lead to a major life threatening interaction when taken with Metoclopramide