DDInter241 DDInter856
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239]
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Bromfenac {u} (Compound) resembles {v} (Compound) Balsalazide
Bromfenac {u} (Compound) resembles {v} (Compound) Suprofen
Bromfenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Bromfenac {u} (Compound) binds {v} (Gene) PTGS2
Bromfenac {u} (Compound) upregulates {v} (Gene) DDX10
Bromfenac {u} (Compound) is included by {v} (Pharmacologic Class) Cyclooxygenase Inhibitors
Bromfenac {u} (Compound) downregulates {v} (Gene) IFRD2
Bromfenac {u} (Compound) causes {v} (Side Effect) Eye pain
Bromfenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Bromfenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Bromfenac (Compound) resembles Balsalazide (Compound)
Bromfenac (Compound) resembles Suprofen (Compound)
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Bromfenac (Compound) binds PTGS2 (Gene)
Bromfenac (Compound) upregulates DDX10 (Gene)
Bromfenac (Compound) is included by Cyclooxygenase Inhibitors (Pharmacologic Class)
Bromfenac (Compound) downregulates IFRD2 (Gene)
Bromfenac (Compound) causes Eye pain (Side Effect)
Bromfenac may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Bromfenac may cause a minor interaction that can limit clinical effects when taken with Linaclotide