DDInter350 DDInter1939
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting . A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug .
Chlorambucil {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) downregulates {v} (Gene) AURKA
AURKA {u} (Gene) is upregulated by {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) downregulates {v} (Gene) UBE2C
UBE2C {u} (Gene) is downregulated by {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) causes {v} (Side Effect) Febrile neutropenia
Febrile neutropenia {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Chlorambucil {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) resembles {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Vinorelbine
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Chlorambucil {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Chlorambucil (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vinorelbine (Compound)
Chlorambucil (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Vinorelbine (Compound)
Chlorambucil (Compound) downregulates AURKA (Gene) and AURKA (Gene) is upregulated by Vinorelbine (Compound)
Chlorambucil (Compound) downregulates UBE2C (Gene) and UBE2C (Gene) is downregulated by Vinorelbine (Compound)
Chlorambucil (Compound) causes Febrile neutropenia (Side Effect) and Febrile neutropenia (Side Effect) is caused by Vinorelbine (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Chlorambucil (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vincristine (Compound) and Vincristine (Compound) resembles Vinorelbine (Compound)
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) resembles breast cancer (Disease) and breast cancer (Disease) is treated by Vinorelbine (Compound)
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine
Chlorambucil (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Vincristine (Compound) and Vincristine (Compound) resembles Vinorelbine (Compound)