DDInter458 DDInter1298
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) regulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Nisoldipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is downregulated by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nisoldipine (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Nisoldipine (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Nisoldipine (Compound)
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Nisoldipine (Compound)
Cyclosporine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Nisoldipine (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amlodipine (Compound) and Amlodipine (Compound) resembles Nisoldipine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nimodipine (Compound) and Nimodipine (Compound) resembles Nisoldipine (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Amlodipine (Compound) and Amlodipine (Compound) resembles Nisoldipine (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) regulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Nisoldipine (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is downregulated by Nicardipine (Compound) and Nicardipine (Compound) resembles Nisoldipine (Compound)