DDInter1822 DDInter815
Aminoglycosides, many of which are derived directly from _Streptomyces_ spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics.[A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.[L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.[A232294, A232349, L
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams. This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity which may limit its use.
Tobramycin {u} (Compound) resembles {v} (Compound) Gentamicin
Tobramycin {u} (Compound) resembles {v} (Compound) Arbekacin
Arbekacin {u} (Compound) resembles {v} (Compound) Gentamicin
Tobramycin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Gentamicin
Tobramycin {u} (Compound) causes {v} (Side Effect) Respiratory depression
Respiratory depression {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Tobramycin {u} (Compound) resembles {v} (Compound) Neomycin
Neomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Tobramycin {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Tobramycin {u} (Compound) resembles {v} (Compound) Arbekacin
Arbekacin {u} (Compound) resembles {v} (Compound) Neomycin
Neomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Tobramycin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Netilmicin
Netilmicin {u} (Compound) resembles {v} (Compound) Gentamicin
Tobramycin {u} (Compound) causes {v} (Side Effect) Respiratory depression
Respiratory depression {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gentamicin
Tobramycin {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Tobramycin (Compound) resembles Gentamicin (Compound)
Tobramycin (Compound) resembles Arbekacin (Compound) and Arbekacin (Compound) resembles Gentamicin (Compound)
Tobramycin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Gentamicin (Compound)
Tobramycin (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Gentamicin (Compound)
Tobramycin (Compound) resembles Neomycin (Compound) and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Tobramycin (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) resembles Gentamicin (Compound) and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Tobramycin (Compound) resembles Arbekacin (Compound) and Arbekacin (Compound) resembles Neomycin (Compound) and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin
Tobramycin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Netilmicin (Compound) and Netilmicin (Compound) resembles Gentamicin (Compound)
Tobramycin (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Gentamicin
Tobramycin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin