DDInter1042 DDInter16
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Acetohexamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amcinonide
Acetohexamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tromethamine
Acetohexamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lorlatinib
Acetohexamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bortezomib
Acetohexamide {u} may lead to a major life threatening interaction when taken with {v} Trovafloxacin
Acetohexamide {u} may lead to a major life threatening interaction when taken with {v} Fluconazole
Acetohexamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide
Acetohexamide may cause a minor interaction that can limit clinical effects when taken with Tromethamine
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib
Acetohexamide may lead to a major life threatening interaction when taken with Trovafloxacin
Acetohexamide may lead to a major life threatening interaction when taken with Fluconazole