DDInter1042 DDInter1866
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Trifluoperazine {u} (Compound) resembles {v} (Compound) Clozapine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Zuclopenthixol
Trifluoperazine {u} (Compound) binds {v} (Gene) ADRA1A
Trifluoperazine {u} (Compound) upregulates {v} (Gene) SREBF2
Trifluoperazine {u} (Compound) palliates {v} (Disease) schizophrenia
Trifluoperazine {u} (Compound) is included by {v} (Pharmacologic Class) Phenothiazines
Trifluoperazine {u} (Compound) downregulates {v} (Gene) PSMD2
Trifluoperazine {u} (Compound) causes {v} (Side Effect) Convulsion
Trifluoperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magaldrate
Trifluoperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Trifluoperazine (Compound) resembles Clozapine (Compound)
Trifluoperazine (Compound) resembles Zuclopenthixol (Compound)
Trifluoperazine (Compound) binds ADRA1A (Gene)
Trifluoperazine (Compound) upregulates SREBF2 (Gene)
Trifluoperazine (Compound) palliates schizophrenia (Disease)
Trifluoperazine (Compound) is included by Phenothiazines (Pharmacologic Class)
Trifluoperazine (Compound) downregulates PSMD2 (Gene)
Trifluoperazine (Compound) causes Convulsion (Side Effect)
Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate