DDInter48 DDInter1951
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout. It was initially approved by the FDA in 1966 and is now formulated by several manufacturers.
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Allopurinol {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Ceftriaxone
Ceftriaxone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Allopurinol {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Levocarnitine
Levocarnitine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Allopurinol {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Pravastatin
Pravastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Allopurinol {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Procarbazine
Procarbazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Indomethacin
Indomethacin {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Allopurinol {u} (Compound) causes {v} (Side Effect) Retinitis
Retinitis {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is palliated by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Allopurinol {u} (Compound) causes {v} (Side Effect) Status epilepticus
Status epilepticus {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Warfarin
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is treated by Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Allopurinol (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Ceftriaxone (Compound) and Ceftriaxone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Allopurinol (Compound) binds XDH (Gene) and XDH (Gene) is bound by Levocarnitine (Compound) and Levocarnitine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Allopurinol (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Pravastatin (Compound) and Pravastatin may cause a minor interaction that can limit clinical effects when taken with Warfarin
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is treated by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Allopurinol (Compound) binds XDH (Gene) and XDH (Gene) is bound by Procarbazine (Compound) and Procarbazine may cause a minor interaction that can limit clinical effects when taken with Warfarin
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is treated by Indomethacin (Compound) and Indomethacin may lead to a major life threatening interaction when taken with Warfarin
Allopurinol (Compound) causes Retinitis (Side Effect) and Retinitis (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Warfarin
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is palliated by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may lead to a major life threatening interaction when taken with Warfarin
Allopurinol (Compound) causes Status epilepticus (Side Effect) and Status epilepticus (Side Effect) is caused by Oxcarbazepine (Compound) and Oxcarbazepine (Compound) resembles Warfarin (Compound)