DDInter453 DDInter1747
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Cyclizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Cyclizine {u} (Compound) resembles {v} (Compound) Trimethaphan
Cyclizine {u} (Compound) binds {v} (Gene) CYP2C9
Cyclizine {u} (Compound) upregulates {v} (Gene) STXBP1
Cyclizine {u} (Compound) downregulates {v} (Gene) TNIP1
Cyclizine {u} (Compound) causes {v} (Side Effect) Hallucinations, mixed
Cyclizine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Cyclizine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Cyclizine (Compound) resembles Ifenprodil (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Cyclizine (Compound) resembles Trimethaphan (Compound)
Cyclizine (Compound) binds CYP2C9 (Gene)
Cyclizine (Compound) upregulates STXBP1 (Gene)
Cyclizine (Compound) downregulates TNIP1 (Gene)
Cyclizine (Compound) causes Hallucinations, mixed (Side Effect)
Cyclizine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Cyclizine may lead to a major life threatening interaction when taken with Zonisamide