DDInter535 DDInter1175
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Diazoxide {u} (Compound) downregulates {v} (Gene) CDKN1B
CDKN1B {u} (Gene) is downregulated by {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Drug interaction
Drug interaction {u} (Side Effect) is caused by {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) downregulates {v} (Gene) CDKN1B
CDKN1B {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Drug interaction
Drug interaction {u} (Side Effect) is caused by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Trimipramine
Trimipramine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Diazoxide (Compound) downregulates CDKN1B (Gene) and CDKN1B (Gene) is downregulated by Methotrimeprazine (Compound)
Diazoxide (Compound) causes Drug interaction (Side Effect) and Drug interaction (Side Effect) is caused by Methotrimeprazine (Compound)
Diazoxide (Compound) downregulates CDKN1B (Gene) and CDKN1B (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Methotrimeprazine (Compound)
Diazoxide (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Thioridazine (Compound) and Thioridazine (Compound) resembles Methotrimeprazine (Compound)
Diazoxide (Compound) causes Drug interaction (Side Effect) and Drug interaction (Side Effect) is caused by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine
Diazoxide (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Diazoxide (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Trimipramine (Compound) and Trimipramine (Compound) resembles Methotrimeprazine (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Methotrimeprazine (Compound)
Diazoxide (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methotrimeprazine (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine