DDInter762 DDInter576
A benzodiazepine derivative used mainly as a hypnotic.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Flurazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) resembles {v} (Compound) Flunitrazepam
Flunitrazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) resembles {v} (Compound) Amodiaquine
Amodiaquine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) resembles {v} (Compound) Amodiaquine
Amodiaquine {u} (Compound) downregulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) resembles {v} (Compound) Estazolam
Estazolam {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Flurazepam {u} (Compound) resembles {v} (Compound) Amodiaquine
Amodiaquine {u} (Compound) upregulates {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Flurazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Flurazepam (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Disulfiram (Compound)
Flurazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Flurazepam (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Flurazepam (Compound) resembles Flunitrazepam (Compound) and Flunitrazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Flurazepam (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Disulfiram (Compound)
Flurazepam (Compound) resembles Amodiaquine (Compound) and Amodiaquine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Disulfiram (Compound)
Flurazepam (Compound) resembles Amodiaquine (Compound) and Amodiaquine (Compound) downregulates CTSL (Gene) and CTSL (Gene) is upregulated by Disulfiram (Compound)
Flurazepam (Compound) resembles Estazolam (Compound) and Estazolam (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Flurazepam (Compound) resembles Amodiaquine (Compound) and Amodiaquine (Compound) upregulates MOK (Gene) and MOK (Gene) is upregulated by Disulfiram (Compound)