DDInter490 DDInter255
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Deferoxamine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Deferoxamine {u} (Compound) palliates {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Deferoxamine {u} (Compound) palliates {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is associated with {v} (Gene) PRKAG2
PRKAG2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Deferoxamine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Deferoxamine (Compound) palliates chronic kidney failure (Disease) and chronic kidney failure (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Deferoxamine (Compound) palliates chronic kidney failure (Disease) and chronic kidney failure (Disease) is associated with PRKAG2 (Gene) and PRKAG2 (Gene) is downregulated by Busulfan (Compound)