DDInter576 DDInter1432
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Perphenazine
Disulfiram {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Perphenazine
Disulfiram {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Perphenazine
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Perphenazine
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Perphenazine
Disulfiram {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Perphenazine
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Perphenazine
Disulfiram {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Perphenazine
Disulfiram {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Perphenazine
Disulfiram {u} (Compound) downregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is regulated by {v} (Gene) CALM1
CALM1 {u} (Gene) is bound by {v} (Compound) Perphenazine
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Perphenazine (Compound)
Disulfiram (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Perphenazine (Compound)
Disulfiram (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Perphenazine (Compound)
Disulfiram (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Perphenazine (Compound)
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Perphenazine (Compound)
Disulfiram (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Perphenazine (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Promazine (Compound) and Promazine (Compound) resembles Perphenazine (Compound)
Disulfiram (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Triflupromazine (Compound) and Triflupromazine (Compound) resembles Perphenazine (Compound)
Disulfiram (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Triflupromazine (Compound) and Triflupromazine (Compound) resembles Perphenazine (Compound)
Disulfiram (Compound) downregulates JADE2 (Gene) and JADE2 (Gene) is regulated by CALM1 (Gene) and CALM1 (Gene) is bound by Perphenazine (Compound)