DDInter1868 DDInter1147
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and 2. The combination product of trifluridine with tipiracil marketed as Lonsurf has been approved in Japan, the United States, and the European Union for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In the anticancer therapy, trifluridine acts as a thymidine-based nucleoside metabolic inhibitor that gets
Meningococcal group C polysaccharide is group-specific polysaccharide antigens extracted and purified from *Neisseria meningitidis* serogroup C. *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup C.
Trifluridine {u} (Compound) resembles {v} (Compound) Telbivudine
Trifluridine {u} (Compound) resembles {v} (Compound) Pentostatin
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Trifluridine {u} (Compound) binds {v} (Gene) SLC22A6
Trifluridine {u} (Compound) upregulates {v} (Gene) CRIP1
Trifluridine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Trifluridine {u} (Compound) downregulates {v} (Gene) UBQLN2
Trifluridine {u} (Compound) causes {v} (Side Effect) Keratitis sicca
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegfilgrastim
Trifluridine {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Trifluridine (Compound) resembles Telbivudine (Compound)
Trifluridine (Compound) resembles Pentostatin (Compound)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Trifluridine (Compound) binds SLC22A6 (Gene)
Trifluridine (Compound) upregulates CRIP1 (Gene)
Trifluridine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Trifluridine (Compound) downregulates UBQLN2 (Gene)
Trifluridine (Compound) causes Keratitis sicca (Side Effect)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim
Trifluridine may lead to a major life threatening interaction when taken with Clozapine