DDInter1447 DDInter1082
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) resembles {v} (Compound) Fenproporex
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phentermine {u} (Compound) treats {v} (Disease) obesity
Phentermine {u} (Compound) binds {v} (Gene) CYP1A2
Phentermine {u} (Compound) upregulates {v} (Gene) TBX2
Phentermine {u} (Compound) is included by {v} (Pharmacologic Class) Increased Sympathetic Activity
Phentermine {u} (Compound) downregulates {v} (Gene) UGDH
Phentermine {u} (Compound) causes {v} (Side Effect) Pulmonary hypertension
Phentermine (Compound) resembles Tranylcypromine (Compound)
Phentermine (Compound) resembles Fenproporex (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Phentermine may lead to a major life threatening interaction when taken with Phenelzine
Phentermine (Compound) treats obesity (Disease)
Phentermine (Compound) binds CYP1A2 (Gene)
Phentermine (Compound) upregulates TBX2 (Gene)
Phentermine (Compound) is included by Increased Sympathetic Activity (Pharmacologic Class)
Phentermine (Compound) downregulates UGDH (Gene)
Phentermine (Compound) causes Pulmonary hypertension (Side Effect)