DDInter438 DDInter255
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Conivaptan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Conivaptan {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Busulfan
Conivaptan {u} (Compound) resembles {v} (Compound) Tolvaptan
Tolvaptan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Conivaptan {u} (Compound) resembles {v} (Compound) Tolvaptan
Tolvaptan {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Conivaptan {u} (Compound) resembles {v} (Compound) Deferasirox
Deferasirox {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Conivaptan {u} (Compound) resembles {v} (Compound) Atorvastatin
Atorvastatin {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Conivaptan {u} (Compound) resembles {v} (Compound) Atorvastatin
Atorvastatin {u} (Compound) upregulates {v} (Gene) PRKCD
PRKCD {u} (Gene) is downregulated by {v} (Compound) Busulfan
Conivaptan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Conivaptan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Bexarotene {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Conivaptan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Abiraterone
Abiraterone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Conivaptan (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Busulfan (Compound)
Conivaptan (Compound) resembles Tolvaptan (Compound) and Tolvaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Conivaptan (Compound) resembles Tolvaptan (Compound) and Tolvaptan (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Busulfan (Compound)
Conivaptan (Compound) resembles Deferasirox (Compound) and Deferasirox (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Conivaptan (Compound) resembles Atorvastatin (Compound) and Atorvastatin (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Busulfan (Compound)
Conivaptan (Compound) resembles Atorvastatin (Compound) and Atorvastatin (Compound) upregulates PRKCD (Gene) and PRKCD (Gene) is downregulated by Busulfan (Compound)
Conivaptan may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Conivaptan may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Conivaptan may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abiraterone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)