DDInter1570 DDInter893
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of [quinacrine] with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.** Hydroxychloroquine was granted FDA approval on 18 April 1955. A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.
Ranolazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Hydroxychloroquine
Ranolazine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Ranolazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Chloroquine
Chloroquine {u} (Compound) resembles {v} (Compound) Hydroxychloroquine
Ranolazine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Chloroquine
Chloroquine {u} (Compound) resembles {v} (Compound) Hydroxychloroquine
Ranolazine {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxychloroquine
Ranolazine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Primaquine
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Ranolazine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Aprepitant
Aprepitant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Ranolazine {u} (Compound) resembles {v} (Compound) Guaifenesin
Guaifenesin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Hydroxychloroquine
Ranolazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Amodiaquine
Amodiaquine {u} (Compound) resembles {v} (Compound) Hydroxychloroquine
Ranolazine {u} (Compound) resembles {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Hydroxychloroquine
Ranolazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Ranolazine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Ranolazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Chloroquine (Compound) and Chloroquine (Compound) resembles Hydroxychloroquine (Compound)
Ranolazine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Chloroquine (Compound) and Chloroquine (Compound) resembles Hydroxychloroquine (Compound)
Ranolazine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine
Ranolazine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Primaquine (Compound) and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Ranolazine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Aprepitant (Compound) and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine
Ranolazine (Compound) resembles Guaifenesin (Compound) and Guaifenesin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Ranolazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Amodiaquine (Compound) and Amodiaquine (Compound) resembles Hydroxychloroquine (Compound)
Ranolazine (Compound) resembles Bupivacaine (Compound) and Bupivacaine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)