DDInter1233 DDInter665
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Mitotane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Ergotamine
Mitotane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Ergotamine
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Dihydroergotamine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Mitotane {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Phenylephrine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Ergotamine
Mitotane {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Clarithromycin {u} may lead to a major life threatening interaction when taken with {v} Ergotamine
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ergotamine
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) resembles {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Ergotamine
Mitotane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ergotamine (Compound)
Mitotane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Bromocriptine (Compound) and Bromocriptine (Compound) resembles Ergotamine (Compound)
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Dihydroergotamine (Compound) and Dihydroergotamine (Compound) resembles Ergotamine (Compound)
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine
Mitotane (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Phenylephrine (Compound) and Phenylephrine may lead to a major life threatening interaction when taken with Ergotamine
Mitotane (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Clarithromycin (Compound) and Clarithromycin may lead to a major life threatening interaction when taken with Ergotamine
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ergotamine (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) resembles Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Bromocriptine and Bromocriptine (Compound) resembles Ergotamine (Compound)