DDInter255 DDInter1789
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Thalidomide
Busulfan {u} (Compound) downregulates {v} (Gene) CCND3
CCND3 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Busulfan {u} (Compound) causes {v} (Side Effect) Hepatomegaly
Hepatomegaly {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Thalidomide
Busulfan {u} (Compound) downregulates {v} (Gene) CCND3
CCND3 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Thalidomide
Busulfan {u} (Compound) causes {v} (Side Effect) Hepatomegaly
Hepatomegaly {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Busulfan {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Thalidomide
Busulfan {u} (Compound) causes {v} (Side Effect) Menopause
Menopause {u} (Side Effect) is caused by {v} (Compound) Zaleplon
Zaleplon {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Busulfan {u} (Compound) binds {v} (Gene) MGST2
MGST2 {u} (Gene) regulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Thalidomide
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) TNF
TNF {u} (Gene) is bound by {v} (Compound) Thalidomide
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Busulfan (Compound) downregulates CCND3 (Gene) and CCND3 (Gene) is upregulated by Thalidomide (Compound)
Busulfan (Compound) causes Hepatomegaly (Side Effect) and Hepatomegaly (Side Effect) is caused by Thalidomide (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Thalidomide (Compound)
Busulfan (Compound) downregulates CCND3 (Gene) and CCND3 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Busulfan (Compound) causes Hepatomegaly (Side Effect) and Hepatomegaly (Side Effect) is caused by Clarithromycin (Compound) and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Busulfan (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Thalidomide (Compound)
Busulfan (Compound) causes Menopause (Side Effect) and Menopause (Side Effect) is caused by Zaleplon (Compound) and Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Busulfan (Compound) binds MGST2 (Gene) and MGST2 (Gene) regulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Thalidomide (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with TNF (Gene) and TNF (Gene) is bound by Thalidomide (Compound)