DDInter458 DDInter157
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. It is structurally related to erythromycin . Azithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism. This differentiates azithromycin from other types of macrolides . In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine]. The results were positive, all patients taking the combination were virologically cured within 6 days of treatment, however, larger studies are required.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is upregulated by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TSTA3
TSTA3 {u} (Gene) is downregulated by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is downregulated by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Telithromycin
Telithromycin {u} (Compound) resembles {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is regulated by {v} (Gene) TSTA3
TSTA3 {u} (Gene) is downregulated by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TSTA3
TSTA3 {u} (Gene) regulates {v} (Gene) WDR7
WDR7 {u} (Gene) is upregulated by {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Roxithromycin
Roxithromycin {u} (Compound) resembles {v} (Compound) Azithromycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) RFC2
RFC2 {u} (Gene) regulates {v} (Gene) ETFB
ETFB {u} (Gene) is downregulated by {v} (Compound) Azithromycin
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Azithromycin (Compound)
Cyclosporine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is upregulated by Azithromycin (Compound)
Cyclosporine (Compound) downregulates TSTA3 (Gene) and TSTA3 (Gene) is downregulated by Azithromycin (Compound)
Cyclosporine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is downregulated by Azithromycin (Compound)
Cyclosporine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Azithromycin (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Telithromycin (Compound) and Telithromycin (Compound) resembles Azithromycin (Compound)
Cyclosporine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is regulated by TSTA3 (Gene) and TSTA3 (Gene) is downregulated by Azithromycin (Compound)
Cyclosporine (Compound) downregulates TSTA3 (Gene) and TSTA3 (Gene) regulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Azithromycin (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Roxithromycin (Compound) and Roxithromycin (Compound) resembles Azithromycin (Compound)
Cyclosporine (Compound) downregulates RFC2 (Gene) and RFC2 (Gene) regulates ETFB (Gene) and ETFB (Gene) is downregulated by Azithromycin (Compound)