DDInter458 DDInter737
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010. Fingolimod was also studied for the treatment of COVID-19, the disease caused by infection with the SARS-CoV-2 virus.[L12654,L12657]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Fingolimod
Cyclosporine {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Fingolimod
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Olanzapine
Olanzapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fingolimod
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fingolimod
Cyclosporine {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Pyridostigmine
Pyridostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fingolimod
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fingolimod
Cyclosporine {u} (Compound) causes {v} (Side Effect) Lymphoproliferative disorder
Lymphoproliferative disorder {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Fingolimod
Cyclosporine {u} (Compound) upregulates {v} (Gene) ARCN1
ARCN1 {u} (Gene) is downregulated by {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is treated by {v} (Compound) Fingolimod
Cyclosporine {u} (Compound) upregulates {v} (Gene) CBLB
CBLB {u} (Gene) is associated with {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is treated by {v} (Compound) Fingolimod
Cyclosporine {u} (Compound) upregulates {v} (Gene) CBLB
CBLB {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Mifepristone {u} may lead to a major life threatening interaction when taken with {v} Fingolimod
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Cyclosporine (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Fingolimod (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Olanzapine (Compound) and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Cyclosporine (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Pyridostigmine (Compound) and Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Cyclosporine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Cyclosporine (Compound) causes Lymphoproliferative disorder (Side Effect) and Lymphoproliferative disorder (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may lead to a major life threatening interaction when taken with Fingolimod
Cyclosporine (Compound) upregulates ARCN1 (Gene) and ARCN1 (Gene) is downregulated by multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Fingolimod (Compound)
Cyclosporine (Compound) upregulates CBLB (Gene) and CBLB (Gene) is associated with multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Fingolimod (Compound)
Cyclosporine (Compound) upregulates CBLB (Gene) and CBLB (Gene) is upregulated by Mifepristone (Compound) and Mifepristone may lead to a major life threatening interaction when taken with Fingolimod