DDInter1554 DDInter1008
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Quinapril {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Quinapril {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Quinapril {u} (Compound) resembles {v} (Compound) Trandolapril
Trandolapril {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) resembles {v} (Compound) Benazepril
Benazepril {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) resembles {v} (Compound) Labetalol
Labetalol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) resembles {v} (Compound) Perindopril
Perindopril {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) CYP17A1
CYP17A1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Quinapril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Quinapril (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Ketoconazole (Compound)
Quinapril (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Quinapril (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Quinapril (Compound) resembles Trandolapril (Compound) and Trandolapril (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ketoconazole (Compound)
Quinapril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Ketoconazole (Compound)
Quinapril (Compound) resembles Benazepril (Compound) and Benazepril (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Ketoconazole (Compound)
Quinapril (Compound) resembles Labetalol (Compound) and Labetalol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ketoconazole (Compound)
Quinapril (Compound) resembles Perindopril (Compound) and Perindopril (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Ketoconazole (Compound)
Quinapril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with CYP17A1 (Gene) and CYP17A1 (Gene) is bound by Ketoconazole (Compound)
Quinapril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with HMGCR (Gene) and HMGCR (Gene) is upregulated by Ketoconazole (Compound)