DDInter458 DDInter769
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct from the fungal derivatives of this therapeutic class. Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) downregulates {v} (Gene) GTF2A2
GTF2A2 {u} (Gene) is downregulated by {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) upregulates {v} (Gene) SLC35B1
SLC35B1 {u} (Gene) is downregulated by {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvastatin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Pitavastatin
Pitavastatin {u} (Compound) resembles {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is upregulated by {v} (Compound) Pitavastatin
Pitavastatin {u} (Compound) resembles {v} (Compound) Fluvastatin
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLGB1
GOLGB1 {u} (Gene) is regulated by {v} (Gene) RHOA
RHOA {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Fluvastatin (Compound)
Cyclosporine (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Fluvastatin (Compound)
Cyclosporine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is upregulated by Fluvastatin (Compound)
Cyclosporine (Compound) downregulates GTF2A2 (Gene) and GTF2A2 (Gene) is downregulated by Fluvastatin (Compound)
Cyclosporine (Compound) upregulates SLC35B1 (Gene) and SLC35B1 (Gene) is downregulated by Fluvastatin (Compound)
Cyclosporine (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Fluvastatin (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Rosuvastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pitavastatin (Compound) and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Cyclosporine (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Pitavastatin (Compound) and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Cyclosporine (Compound) upregulates GOLGB1 (Gene) and GOLGB1 (Gene) is regulated by RHOA (Gene) and RHOA (Gene) is upregulated by Fluvastatin (Compound)