DDInter412 DDInter1376
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Clonidine {u} (Compound) resembles {v} (Compound) Diclofenac
Clonidine {u} (Compound) treats {v} (Disease) glaucoma
Clonidine {u} (Compound) binds {v} (Gene) SLC6A2
Clonidine {u} (Compound) upregulates {v} (Gene) MAL
Clonidine {u} (Compound) palliates {v} (Disease) attention deficit hyperactivity disorder
Clonidine {u} (Compound) is included by {v} (Pharmacologic Class) Adrenergic alpha2-Agonists
Clonidine {u} (Compound) downregulates {v} (Gene) SHC1
Clonidine {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Clonidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Clonidine (Compound) resembles Diclofenac (Compound)
Clonidine (Compound) treats glaucoma (Disease)
Clonidine (Compound) binds SLC6A2 (Gene)
Clonidine (Compound) upregulates MAL (Gene)
Clonidine (Compound) palliates attention deficit hyperactivity disorder (Disease)
Clonidine (Compound) is included by Adrenergic alpha2-Agonists (Pharmacologic Class)
Clonidine (Compound) downregulates SHC1 (Gene)
Clonidine (Compound) causes Gastrointestinal pain (Side Effect)
Clonidine may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide