DDInter154 DDInter362
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Azelastine {u} (Compound) resembles {v} (Compound) Cloperastine
Cloperastine {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Chlorpheniramine
Azelastine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Histamine H1 Receptor Antagonists {u} (Pharmacologic Class) includes {v} (Compound) Chlorpheniramine
Azelastine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Chlorpheniramine
Azelastine {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Azelastine {u} (Compound) resembles {v} (Compound) Cloperastine
Cloperastine {u} (Compound) resembles {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Azelastine {u} (Compound) resembles {v} (Compound) Chlorcyclizine
Chlorcyclizine {u} (Compound) resembles {v} (Compound) Mitotane
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Azelastine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Azelastine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Alprazolam
Alprazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Azelastine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Histamine H1 Receptor Antagonists {u} (Pharmacologic Class) includes {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Azelastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Chlorpheniramine (Compound)
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Chlorpheniramine (Compound)
Azelastine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class) and Histamine H1 Receptor Antagonists (Pharmacologic Class) includes Chlorpheniramine (Compound)
Azelastine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Chlorpheniramine (Compound)
Azelastine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Azelastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Azelastine (Compound) resembles Chlorcyclizine (Compound) and Chlorcyclizine (Compound) resembles Mitotane (Compound) and Mitotane (Compound) resembles Chlorpheniramine (Compound)
Azelastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Azelastine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Alprazolam (Compound) and Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Azelastine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class) and Histamine H1 Receptor Antagonists (Pharmacologic Class) includes Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine