DDInter458 DDInter1726
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Clotrimazole {u} (Compound) resembles {v} (Compound) Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) regulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) covaries with {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Sulfinpyrazone
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfinpyrazone (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sulfinpyrazone (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Clotrimazole (Compound) and Clotrimazole (Compound) resembles Sulfinpyrazone (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Paclitaxel (Compound) and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Sulfinpyrazone (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Sulfinpyrazone
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Sulfinpyrazone (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) regulates ABCC5 (Gene) and ABCC5 (Gene) is bound by Sulfinpyrazone (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) covaries with PAK1 (Gene) and PAK1 (Gene) is upregulated by Sulfinpyrazone (Compound)