DDInter458 DDInter1713
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity.[A233325,A232294] Although streptomycin was the first antibiotic determined to be effective against mycobacterium tuberculosis, it has fallen out of favor due to resistance and is now primarily used as adjunctive treatment in cases of multi-drug resistant tuberculosis.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Streptomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Streptomycin
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Piroxicam
Piroxicam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Ceftaroline fosamil
Ceftaroline fosamil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Streptomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Renal impairment
Renal impairment {u} (Side Effect) is caused by {v} (Compound) Etodolac
Etodolac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Streptomycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) MBOAT7
MBOAT7 {u} (Gene) covaries with {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Streptomycin
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Cefoperazone
Cefoperazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephrotoxicity
Nephrotoxicity {u} (Side Effect) is caused by {v} (Compound) Capreomycin
Capreomycin {u} may lead to a major life threatening interaction when taken with {v} Streptomycin
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Cyclosporine (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Piroxicam (Compound) and Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Cyclosporine (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Ceftaroline fosamil (Compound) and Ceftaroline fosamil may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Cyclosporine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Amikacin (Compound) and Amikacin (Compound) resembles Streptomycin (Compound)
Cyclosporine (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Etodolac (Compound) and Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Cyclosporine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Streptomycin
Cyclosporine (Compound) downregulates MBOAT7 (Gene) and MBOAT7 (Gene) covaries with SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Cefoperazone (Compound) and Cefoperazone may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Cyclosporine (Compound) causes Nephrotoxicity (Side Effect) and Nephrotoxicity (Side Effect) is caused by Capreomycin (Compound) and Capreomycin may lead to a major life threatening interaction when taken with Streptomycin