DDInter1845 DDInter453
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Cyclizine
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Cyclizine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Phenelzine
Phenelzine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Ethotoin
Ethotoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Cyclizine
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Doxapram
Doxapram {u} (Compound) resembles {v} (Compound) Cyclizine
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Cyclizine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Phenelzine
Phenelzine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Tranylcypromine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cyclizine (Compound)
Tranylcypromine (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Cyclizine (Compound)
Tranylcypromine (Compound) resembles Phenelzine (Compound) and Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Tranylcypromine (Compound) resembles Ethotoin (Compound) and Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Tranylcypromine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Modafinil (Compound) and Modafinil (Compound) resembles Cyclizine (Compound)
Tranylcypromine (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Tranylcypromine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Tranylcypromine (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Doxapram (Compound) and Doxapram (Compound) resembles Cyclizine (Compound)
Tranylcypromine (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Cyclizine (Compound)
Tranylcypromine (Compound) resembles Phenelzine (Compound) and Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine