DDInter1042 DDInter1494
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Posaconazole {u} (Compound) resembles {v} (Compound) Itraconazole
Posaconazole {u} (Compound) binds {v} (Gene) ABCB1
Posaconazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Posaconazole {u} (Compound) causes {v} (Side Effect) Kidney function abnormal
Posaconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium hydroxide
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Posaconazole {u} may lead to a major life threatening interaction when taken with {v} Panobinostat
Posaconazole {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Posaconazole (Compound) resembles Itraconazole (Compound)
Posaconazole (Compound) binds ABCB1 (Gene)
Posaconazole (Compound) is included by Azoles (Pharmacologic Class)
Posaconazole (Compound) causes Kidney function abnormal (Side Effect)
Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine
Posaconazole may lead to a major life threatening interaction when taken with Panobinostat
Posaconazole may lead to a major life threatening interaction when taken with Leflunomide