DDInter336 DDInter1175
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Drug interaction
Drug interaction {u} (Side Effect) is caused by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Trimipramine
Trimipramine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Mequitazine
Mequitazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Promethazine
Promethazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrimeprazine
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) interacts with {v} (Gene) ADRA1B
ADRA1B {u} (Gene) is bound by {v} (Compound) Methotrimeprazine
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Methotrimeprazine
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Methotrimeprazine (Compound)
Celecoxib (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Methotrimeprazine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methotrimeprazine (Compound)
Celecoxib (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Celecoxib (Compound) causes Drug interaction (Side Effect) and Drug interaction (Side Effect) is caused by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine
Celecoxib (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Trimipramine (Compound) and Trimipramine (Compound) resembles Methotrimeprazine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mequitazine (Compound) and Mequitazine (Compound) resembles Methotrimeprazine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Promethazine (Compound) and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) interacts with ADRA1B (Gene) and ADRA1B (Gene) is bound by Methotrimeprazine (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Methotrimeprazine (Compound)