DDInter901 DDInter1008
Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Ibutilide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Ibutilide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Ibutilide {u} (Compound) resembles {v} (Compound) Dronedarone
Dronedarone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ibutilide {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Ibutilide {u} (Compound) resembles {v} (Compound) Sotalol
Sotalol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Ibutilide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) FDPS
FDPS {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Ibutilide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Metronidazole {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ibutilide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Thalidomide {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Ibutilide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Ibutilide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lactulose
Lactulose {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Ibutilide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ketoconazole (Compound)
Ibutilide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Ibutilide (Compound) resembles Dronedarone (Compound) and Dronedarone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketoconazole (Compound)
Ibutilide (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Ibutilide (Compound) resembles Sotalol (Compound) and Sotalol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ketoconazole (Compound)
Ibutilide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates FDPS (Gene) and FDPS (Gene) is upregulated by Ketoconazole (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ketoconazole (Compound)
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ketoconazole (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Posaconazole and Posaconazole (Compound) resembles Ketoconazole (Compound)
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ketoconazole (Compound)