DDInter1305 DDInter1191
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated pneumonia in one patient with long-term immunosuppression. The efficacy of methylprednisolone in novel coronavirus pneumonia is being investigated further in clinical trials.
Nitroprusside {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Ambenonium
Ambenonium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clobetasol propionate
Clobetasol propionate {u} (Compound) resembles {v} (Compound) Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Isoniazid
Isoniazid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is upregulated by {v} (Compound) Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) IER3
IER3 {u} (Gene) is downregulated by {v} (Compound) Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Isoprenaline
Isoprenaline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Norfloxacin {u} may lead to a major life threatening interaction when taken with {v} Methylprednisolone
Nitroprusside (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Ambenonium (Compound) and Ambenonium may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Methylprednisolone (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clobetasol propionate (Compound) and Clobetasol propionate (Compound) resembles Methylprednisolone (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Isoniazid (Compound) and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Methylprednisolone (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates IER3 (Gene) and IER3 (Gene) is downregulated by Methylprednisolone (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Isoprenaline (Compound) and Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Norfloxacin (Compound) and Norfloxacin may lead to a major life threatening interaction when taken with Methylprednisolone