DDInter408 DDInter1840
A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Clofibrate {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Clofibrate {u} (Compound) resembles {v} (Compound) Benzocaine
Benzocaine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Clofibrate {u} (Compound) resembles {v} (Compound) Bezafibrate
Bezafibrate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trabectedin
Clofibrate {u} (Compound) resembles {v} (Compound) Fenofibrate
Fenofibrate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trabectedin
Clofibrate {u} (Compound) resembles {v} (Compound) Bezafibrate
Bezafibrate {u} (Compound) causes {v} (Side Effect) Alanine aminotransferase increased
Alanine aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Clofibrate {u} (Compound) binds {v} (Gene) PPARA
PPARA {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Clofibrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolbutamide
Tolbutamide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Trabectedin
Clofibrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Repaglinide {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Clofibrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desmopressin
Desmopressin {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Clofibrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desmopressin
Desmopressin {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Clofibrate (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Trabectedin (Compound)
Clofibrate (Compound) resembles Benzocaine (Compound) and Benzocaine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Trabectedin (Compound)
Clofibrate (Compound) resembles Bezafibrate (Compound) and Bezafibrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trabectedin (Compound)
Clofibrate (Compound) resembles Fenofibrate (Compound) and Fenofibrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trabectedin (Compound)
Clofibrate (Compound) resembles Bezafibrate (Compound) and Bezafibrate (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Trabectedin (Compound)
Clofibrate (Compound) binds PPARA (Gene) and PPARA (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Clofibrate may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Trabectedin (Compound)
Clofibrate may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Trabectedin (Compound)
Clofibrate may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Clofibrate may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Trabectedin (Compound)