DDInter1355 DDInter1938
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Vincristine
Oxaliplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Voacamine
Voacamine {u} (Compound) resembles {v} (Compound) Vincristine
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is downregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Oxaliplatin {u} (Compound) binds {v} (Gene) ATP7B
ATP7B {u} (Gene) is associated with {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Oxaliplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is upregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine (Compound) resembles Vincristine (Compound)
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Vincristine (Compound)
Oxaliplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) is downregulated by Vincristine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Voacamine (Compound) and Voacamine (Compound) resembles Vincristine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is downregulated by colon cancer (Disease) and colon cancer (Disease) is treated by Vincristine (Compound)
Oxaliplatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Vinblastine (Compound) and Vinblastine (Compound) resembles Vincristine (Compound)
Oxaliplatin (Compound) binds ATP7B (Gene) and ATP7B (Gene) is associated with kidney cancer (Disease) and kidney cancer (Disease) is treated by Vincristine (Compound)
Oxaliplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) is upregulated by colon cancer (Disease) and colon cancer (Disease) is treated by Vincristine (Compound)