DDInter458 DDInter480
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor selectivity is clinically advantageous in overactive bladder syndrome treatments.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) upregulates {v} (Gene) RBKS
RBKS {u} (Gene) is upregulated by {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) upregulates {v} (Gene) RBKS
RBKS {u} (Gene) is regulated by {v} (Gene) DHX29
DHX29 {u} (Gene) is upregulated by {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is regulated by {v} (Gene) BAD
BAD {u} (Gene) is downregulated by {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Darifenacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Darifenacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Darifenacin
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Darifenacin (Compound)
Cyclosporine (Compound) upregulates RBKS (Gene) and RBKS (Gene) is upregulated by Darifenacin (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Darifenacin (Compound)
Cyclosporine (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Darifenacin (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Darifenacin (Compound)
Cyclosporine (Compound) upregulates RBKS (Gene) and RBKS (Gene) is regulated by DHX29 (Gene) and DHX29 (Gene) is upregulated by Darifenacin (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is regulated by BAD (Gene) and BAD (Gene) is downregulated by Darifenacin (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin
Cyclosporine (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Darifenacin (Compound)
Cyclosporine (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin