DDInter1397 DDInter505
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52. It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients. Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desirudin
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Apixaban
Apixaban {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Paroxetine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desirudin
Paroxetine {u} (Compound) causes {v} (Side Effect) Yawning
Yawning {u} (Side Effect) is caused by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desirudin
Paroxetine {u} (Compound) causes {v} (Side Effect) Vesiculobullous rash
Vesiculobullous rash {u} (Side Effect) is caused by {v} (Compound) Etodolac
Etodolac {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Paroxetine {u} (Compound) downregulates {v} (Gene) PRPF4
PRPF4 {u} (Gene) is bound by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desirudin
Paroxetine {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desirudin
Paroxetine {u} (Compound) downregulates {v} (Gene) PRPF4
PRPF4 {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Paroxetine {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desirudin
Paroxetine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Triamcinolone
Triamcinolone {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Paroxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Paroxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Apixaban (Compound) and Apixaban may lead to a major life threatening interaction when taken with Desirudin
Paroxetine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Paroxetine (Compound) causes Yawning (Side Effect) and Yawning (Side Effect) is caused by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Paroxetine (Compound) causes Vesiculobullous rash (Side Effect) and Vesiculobullous rash (Side Effect) is caused by Etodolac (Compound) and Etodolac may lead to a major life threatening interaction when taken with Desirudin
Paroxetine (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is bound by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Paroxetine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Paroxetine (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is downregulated by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Desirudin
Paroxetine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is downregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Paroxetine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Triamcinolone (Compound) and Triamcinolone may lead to a major life threatening interaction when taken with Desirudin