DDInter1199 DDInter1376
A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Metolazone {u} (Compound) resembles {v} (Compound) Indapamide
Metolazone {u} (Compound) resembles {v} (Compound) Benzthiazide
Metolazone {u} (Compound) treats {v} (Disease) hypertension
Metolazone {u} (Compound) binds {v} (Gene) CA9
Metolazone {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Metolazone {u} (Compound) downregulates {v} (Gene) SLC38A1
Metolazone {u} (Compound) causes {v} (Side Effect) Back pain
Metolazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Scopolamine
Metolazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxycycline
Metolazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Toremifene
Metolazone (Compound) resembles Indapamide (Compound)
Metolazone (Compound) resembles Benzthiazide (Compound)
Metolazone (Compound) treats hypertension (Disease)
Metolazone (Compound) binds CA9 (Gene)
Metolazone (Compound) is included by Increased Diuresis (Pharmacologic Class)
Metolazone (Compound) downregulates SLC38A1 (Gene)
Metolazone (Compound) causes Back pain (Side Effect)
Metolazone may cause a minor interaction that can limit clinical effects when taken with Scopolamine
Metolazone may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Toremifene