DDInter484 DDInter1627
Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein BCR-ABL. BCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the pathogenesis of CML and 15-30% of ALL cases.[A11377,A33432] Dasatinib also inhibits a spectrum of kinases involved in cancer, including several SRC-family kinases. Unlike [imatinib], another tyrosine kinase used for the treatment of CML and Ph-positive ALL, dasatinib inhibits the active and inactive conformations of the ABL
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Dasatinib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Dasatinib {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Phenytoin
Phenytoin {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Clonazepam {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Phenytoin
Phenytoin {u} (Compound) binds {v} (Gene) SCN2A
SCN2A {u} (Gene) is bound by {v} (Compound) Rufinamide
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Clonazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midazolam
Midazolam {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Primidone
Primidone {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Fosphenytoin
Fosphenytoin {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Dasatinib {u} (Compound) upregulates {v} (Gene) FOS
FOS {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Dasatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Dasatinib (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam and Clonazepam (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) binds SCN2A (Gene) and SCN2A (Gene) is bound by Rufinamide (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam and Clonazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Primidone and Primidone (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Fosphenytoin and Fosphenytoin (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Dasatinib (Compound) upregulates FOS (Gene) and FOS (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)