DDInter1793 DDInter336
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Thiethylperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Sucralfate {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Sucralfate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Nicardipine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pregabalin
Pregabalin {u} (Compound) palliates {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is palliated by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pregabalin
Pregabalin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Trospium {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Escitalopram
Escitalopram {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alprazolam
Alprazolam {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Celecoxib
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipratropium
Ipratropium {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate (Compound) binds ALB (Gene) and ALB (Gene) is bound by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Celecoxib (Compound)
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pregabalin and Pregabalin (Compound) palliates systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is palliated by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pregabalin and Pregabalin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Celecoxib (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Ipratropium and Ipratropium (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Celecoxib (Compound)