DDInter1867 DDInter712
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</sub> receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory disease, famotidine was about 20 to 50 times more potent at inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a weight basis. Famotidine is used in various over-the-counter and off-label uses. While oral formulations of famotidine are more commonly used, the intravenous solution of the drug is available for use in hospital settings.
Triflupromazine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Famotidine
Triflupromazine {u} (Compound) resembles {v} (Compound) Promethazine
Promethazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Famotidine
Triflupromazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Famotidine
Triflupromazine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) regulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Famotidine
Triflupromazine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Famotidine
Triflupromazine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Famotidine
Triflupromazine {u} (Compound) resembles {v} (Compound) Promethazine
Promethazine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Famotidine
Triflupromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Famotidine
Triflupromazine {u} (Compound) resembles {v} (Compound) Chlorpromazine
Chlorpromazine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Famotidine
Triflupromazine {u} (Compound) resembles {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Famotidine
Triflupromazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Famotidine (Compound)
Triflupromazine (Compound) resembles Promethazine (Compound) and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine
Triflupromazine (Compound) resembles Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine
Triflupromazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) regulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Famotidine (Compound)
Triflupromazine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Flurbiprofen (Compound) and Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Famotidine
Triflupromazine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by PCNA (Gene) and PCNA (Gene) is downregulated by Famotidine (Compound)
Triflupromazine (Compound) resembles Promethazine (Compound) and Promethazine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Triflupromazine (Compound) resembles Clomipramine (Compound) and Clomipramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Famotidine (Compound)
Triflupromazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Famotidine (Compound)
Triflupromazine (Compound) resembles Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine