DDInter255 DDInter285
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Busulfan {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Capecitabine
Busulfan {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Busulfan {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capecitabine
Busulfan {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capecitabine
Busulfan {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Gemifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Capecitabine
Busulfan {u} (Compound) causes {v} (Side Effect) Hepatomegaly
Hepatomegaly {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Capecitabine
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Hydroxyurea
Hydroxyurea {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Capecitabine
Busulfan {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Capecitabine
Busulfan {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Fosphenytoin
Fosphenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Capecitabine
Busulfan {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is downregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Capecitabine
Busulfan (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Capecitabine (Compound)
Busulfan (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Capecitabine (Compound)
Busulfan (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Vinblastine (Compound) and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Capecitabine
Busulfan (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Capecitabine
Busulfan (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Gemifloxacin (Compound) and Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Capecitabine
Busulfan (Compound) causes Hepatomegaly (Side Effect) and Hepatomegaly (Side Effect) is caused by Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Hydroxyurea (Compound) and Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine
Busulfan (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine
Busulfan (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Fosphenytoin (Compound) and Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Capecitabine
Busulfan (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is downregulated by colon cancer (Disease) and colon cancer (Disease) is treated by Capecitabine (Compound)