DDInter1867 DDInter826
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guidelines by Diabetes Canada, sulfonylurea drugs are considered a second-line glucose-lowering therapy following metformin. Because sulfonylureas require functional pancreatic beta cells for their therapeutic effectiveness, sulfonylureas are more commonly used for early-stage type 2 diabetes when there is no progressed pancreatic failure. Compared to the first-generation sulfonylureas, such as [tolbutamide] and [chlorpropamide], second-generation sulfonylureas contain a more non-polar side chain in their chemical structure, which enhances their hypoglycemic potency. Compared to other members of the sulfonylurea drug group, glipizide displays rapid absorption and onset of action with the shortest half-life and duration of action, reducing the risk for long-lasting hypoglycemia that is often observed with blood glucose-lowering agents. Glipizide was first approved by the FDA in 1994 and is available in extended-release tablets under the brand name Glucotrol®, as well as in combination with metformin under the brand name Metaglip®.
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Glipizide
Triflupromazine {u} (Compound) upregulates {v} (Gene) GRN
GRN {u} (Gene) is downregulated by {v} (Compound) Glipizide
Triflupromazine {u} (Compound) resembles {v} (Compound) Propiomazine
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Triflupromazine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) CNPY3
CNPY3 {u} (Gene) is upregulated by {v} (Compound) Glipizide
Triflupromazine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) PPARG
PPARG {u} (Gene) is bound by {v} (Compound) Glipizide
Triflupromazine {u} (Compound) upregulates {v} (Gene) GRN
GRN {u} (Gene) regulates {v} (Gene) CEBPB
CEBPB {u} (Gene) is downregulated by {v} (Compound) Glipizide
Triflupromazine {u} (Compound) resembles {v} (Compound) Propiomazine
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glimepiride
Glimepiride {u} (Compound) resembles {v} (Compound) Glipizide
Triflupromazine {u} (Compound) resembles {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) MIF
MIF {u} (Gene) is downregulated by {v} (Compound) Glipizide
Triflupromazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Glipizide (Compound)
Triflupromazine (Compound) upregulates GRN (Gene) and GRN (Gene) is downregulated by Glipizide (Compound)
Triflupromazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide
Triflupromazine (Compound) resembles Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide
Triflupromazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Glipizide (Compound)
Triflupromazine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by PPARG (Gene) and PPARG (Gene) is bound by Glipizide (Compound)
Triflupromazine (Compound) upregulates GRN (Gene) and GRN (Gene) regulates CEBPB (Gene) and CEBPB (Gene) is downregulated by Glipizide (Compound)
Triflupromazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Triflupromazine (Compound) resembles Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide
Triflupromazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates MIF (Gene) and MIF (Gene) is downregulated by Glipizide (Compound)