DDInter150 DDInter745
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Azathioprine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Fludarabine
Azathioprine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Regadenoson
Regadenoson {u} (Compound) resembles {v} (Compound) Fludarabine
Azathioprine {u} (Compound) causes {v} (Side Effect) Myelosuppression
Myelosuppression {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Azathioprine {u} (Compound) causes {v} (Side Effect) X-linked lymphoproliferative syndrome
X-linked lymphoproliferative syndrome {u} (Side Effect) is caused by {v} (Compound) Fingolimod
Fingolimod {u} may lead to a major life threatening interaction when taken with {v} Fludarabine
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Mercaptopurine
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Azathioprine {u} (Compound) causes {v} (Side Effect) Bone marrow depression
Bone marrow depression {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Azathioprine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Fludarabine
Azathioprine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Azathioprine {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Cinoxacin
Cinoxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Azathioprine {u} (Compound) causes {v} (Side Effect) Herpes zoster
Herpes zoster {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Azathioprine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Fludarabine (Compound)
Azathioprine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Regadenoson (Compound) and Regadenoson (Compound) resembles Fludarabine (Compound)
Azathioprine (Compound) causes Myelosuppression (Side Effect) and Myelosuppression (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Azathioprine (Compound) causes X-linked lymphoproliferative syndrome (Side Effect) and X-linked lymphoproliferative syndrome (Side Effect) is caused by Fingolimod (Compound) and Fingolimod may lead to a major life threatening interaction when taken with Fludarabine
Azathioprine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Mercaptopurine (Compound) and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Azathioprine (Compound) causes Bone marrow depression (Side Effect) and Bone marrow depression (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine
Azathioprine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Fludarabine
Azathioprine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound) and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Azathioprine (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Cinoxacin (Compound) and Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine
Azathioprine (Compound) causes Herpes zoster (Side Effect) and Herpes zoster (Side Effect) is caused by Paclitaxel (Compound) and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine