DDInter596 DDInter672
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class. Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822]
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) causes {v} (Side Effect) Otitis media
Otitis media {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may lead to a major life threatening interaction when taken with {v} Escitalopram
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may lead to a major life threatening interaction when taken with {v} Escitalopram
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Doxorubicin {u} (Compound) causes {v} (Side Effect) Otitis media
Otitis media {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Doxorubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Escitalopram (Compound)
Doxorubicin (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Escitalopram (Compound)
Doxorubicin (Compound) causes Otitis media (Side Effect) and Otitis media (Side Effect) is caused by Escitalopram (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may lead to a major life threatening interaction when taken with Escitalopram
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may lead to a major life threatening interaction when taken with Escitalopram
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Doxorubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Doxorubicin (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Doxorubicin (Compound) causes Otitis media (Side Effect) and Otitis media (Side Effect) is caused by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)