DDInter593 DDInter396
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter
Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Clevidipine
Doxepin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clevidipine
Doxepin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Clevidipine
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Doxepin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Nifedipine {u} (Compound) resembles {v} (Compound) Clevidipine
Doxepin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Doxepin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Doxepin {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) binds {v} (Gene) CACNA1C
CACNA1C {u} (Gene) is bound by {v} (Compound) Clevidipine
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Calcium Channel Antagonists {u} (Pharmacologic Class) includes {v} (Compound) Clevidipine
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Clevidipine (Compound)
Doxepin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clevidipine (Compound)
Doxepin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Clevidipine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Doxepin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound) and Nifedipine (Compound) resembles Clevidipine (Compound)
Doxepin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Nicardipine (Compound) and Nicardipine (Compound) resembles Clevidipine (Compound)
Doxepin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Doxepin (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) binds CACNA1C (Gene) and CACNA1C (Gene) is bound by Clevidipine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class) and Calcium Channel Antagonists (Pharmacologic Class) includes Clevidipine (Compound)