DDInter14 DDInter255
Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.[L5756,L5774,F4124,Label] Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Acetaminophen {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) is downregulated by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) causes {v} (Side Effect) Enlargement abdomen
Enlargement abdomen {u} (Side Effect) is caused by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) is upregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) upregulates {v} (Gene) WRB
WRB {u} (Gene) is regulated by {v} (Gene) GFOD1
GFOD1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Busulfan
Acetaminophen {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) regulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Acetaminophen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Acetaminophen (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Busulfan (Compound)
Acetaminophen (Compound) upregulates NNT (Gene) and NNT (Gene) is downregulated by Busulfan (Compound)
Acetaminophen (Compound) causes Enlargement abdomen (Side Effect) and Enlargement abdomen (Side Effect) is caused by Busulfan (Compound)
Acetaminophen (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Acetaminophen (Compound) upregulates NNT (Gene) and NNT (Gene) is upregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Acetaminophen (Compound) upregulates WRB (Gene) and WRB (Gene) is regulated by GFOD1 (Gene) and GFOD1 (Gene) is upregulated by Busulfan (Compound)
Acetaminophen (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Busulfan (Compound)
Acetaminophen (Compound) resembles Metyrosine (Compound) and Metyrosine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Busulfan (Compound)
Acetaminophen (Compound) upregulates NNT (Gene) and NNT (Gene) regulates PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)