DDInter1133 DDInter178
A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCl.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Mechlorethamine {u} (Compound) resembles {v} (Compound) Cyclophosphamide
Mechlorethamine {u} (Compound) treats {v} (Disease) hematologic cancer
Mechlorethamine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Mechlorethamine {u} (Compound) causes {v} (Side Effect) Thrombosis
Mechlorethamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Mechlorethamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Mechlorethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Mechlorethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ustekinumab
Mechlorethamine {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Mechlorethamine {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Mechlorethamine (Compound) treats hematologic cancer (Disease)
Mechlorethamine (Compound) is included by Alkylating Activity (Pharmacologic Class)
Mechlorethamine (Compound) causes Thrombosis (Side Effect)
Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Warfarin
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Mechlorethamine may lead to a major life threatening interaction when taken with Clozapine
Mechlorethamine may lead to a major life threatening interaction when taken with Leflunomide