DDInter76 DDInter1376
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Amiodarone {u} (Compound) resembles {v} (Compound) Dronedarone
Amiodarone {u} (Compound) resembles {v} (Compound) Lucanthone
Amiodarone {u} (Compound) binds {v} (Gene) CACNA2D2
Amiodarone {u} (Compound) upregulates {v} (Gene) HMGCS1
Amiodarone {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 2C9 Inhibitors
Amiodarone {u} (Compound) downregulates {v} (Gene) PRPF4
Amiodarone {u} (Compound) causes {v} (Side Effect) Dermatitis exfoliative
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Amiodarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Liothyronine
Amiodarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nintedanib
Amiodarone (Compound) resembles Dronedarone (Compound)
Amiodarone (Compound) resembles Lucanthone (Compound)
Amiodarone (Compound) binds CACNA2D2 (Gene)
Amiodarone (Compound) upregulates HMGCS1 (Gene)
Amiodarone (Compound) is included by Cytochrome P450 2C9 Inhibitors (Pharmacologic Class)
Amiodarone (Compound) downregulates PRPF4 (Gene)
Amiodarone (Compound) causes Dermatitis exfoliative (Side Effect)
Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine
Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib