DDInter1758 DDInter1016
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Telithromycin {u} (Compound) resembles {v} (Compound) Azithromycin
Telithromycin {u} (Compound) binds {v} (Gene) CYP1A2
Telithromycin {u} (Compound) is included by {v} (Pharmacologic Class) Ketolides
Telithromycin {u} (Compound) causes {v} (Side Effect) Bundle branch block
Telithromycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Telithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paricalcitol
Telithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Telithromycin {u} may lead to a major life threatening interaction when taken with {v} Betrixaban
Telithromycin {u} may lead to a major life threatening interaction when taken with {v} Terfenadine
Telithromycin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Telithromycin (Compound) resembles Azithromycin (Compound)
Telithromycin (Compound) binds CYP1A2 (Gene)
Telithromycin (Compound) is included by Ketolides (Pharmacologic Class)
Telithromycin (Compound) causes Bundle branch block (Side Effect)
Telithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol
Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone
Telithromycin may lead to a major life threatening interaction when taken with Betrixaban
Telithromycin may lead to a major life threatening interaction when taken with Terfenadine
Telithromycin (Compound) resembles Clarithromycin (Compound) and Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin