DDInter596 DDInter393
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) downregulates {v} (Gene) RPP38
RPP38 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) upregulates {v} (Gene) LAP3
LAP3 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Gingival bleeding
Gingival bleeding {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Troleandomycin
Troleandomycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) regulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Doxorubicin {u} (Compound) downregulates {v} (Gene) RPP38
RPP38 {u} (Gene) is regulated by {v} (Gene) CNOT4
CNOT4 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Doxorubicin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compound)
Doxorubicin (Compound) downregulates RPP38 (Gene) and RPP38 (Gene) is upregulated by Clarithromycin (Compound)
Doxorubicin (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Clarithromycin (Compound)
Doxorubicin (Compound) upregulates LAP3 (Gene) and LAP3 (Gene) is downregulated by Clarithromycin (Compound)
Doxorubicin (Compound) causes Gingival bleeding (Side Effect) and Gingival bleeding (Side Effect) is caused by Clarithromycin (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Troleandomycin (Compound) and Troleandomycin (Compound) resembles Clarithromycin (Compound)
Doxorubicin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) regulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Clarithromycin (Compound)
Doxorubicin (Compound) downregulates RPP38 (Gene) and RPP38 (Gene) is regulated by CNOT4 (Gene) and CNOT4 (Gene) is upregulated by Clarithromycin (Compound)