DDInter1397 DDInter951
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound.
Paroxetine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Iobenguane
Paroxetine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Iobenguane
Paroxetine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Iobenguane
Paroxetine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Nefazodone
Nefazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iobenguane
Paroxetine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is regulated by {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Iobenguane
Paroxetine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Ganciclovir
Ganciclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iobenguane
Paroxetine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Iobenguane
Paroxetine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Nefazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iobenguane
Paroxetine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is regulated by {v} (Gene) BPHL
BPHL {u} (Gene) is downregulated by {v} (Compound) Iobenguane
Paroxetine {u} (Compound) downregulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) regulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Iobenguane
Paroxetine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Paroxetine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Iobenguane (Compound)
Paroxetine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Paroxetine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Nefazodone (Compound) and Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Paroxetine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is regulated by MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Iobenguane (Compound)
Paroxetine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ganciclovir (Compound) and Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Paroxetine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Iobenguane (Compound)
Paroxetine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Nefazodone (Compound) and Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Paroxetine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is regulated by BPHL (Gene) and BPHL (Gene) is downregulated by Iobenguane (Compound)
Paroxetine (Compound) downregulates PPP2R3C (Gene) and PPP2R3C (Gene) regulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Iobenguane (Compound)