DDInter1938 DDInter1676
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vincristine {u} (Compound) resembles {v} (Compound) Voacamine
Vincristine {u} (Compound) treats {v} (Disease) muscle cancer
Vincristine {u} (Compound) binds {v} (Gene) TUBB
Vincristine {u} (Compound) upregulates {v} (Gene) TICAM1
Vincristine {u} (Compound) is included by {v} (Pharmacologic Class) Vinca Alkaloids
Vincristine {u} (Compound) downregulates {v} (Gene) BRCA1
Vincristine {u} (Compound) causes {v} (Side Effect) Respiratory distress
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB2A
Vincristine (Compound) resembles Vinorelbine (Compound)
Vincristine (Compound) resembles Voacamine (Compound)
Vincristine (Compound) treats muscle cancer (Disease)
Vincristine (Compound) binds TUBB (Gene)
Vincristine (Compound) upregulates TICAM1 (Gene)
Vincristine (Compound) is included by Vinca Alkaloids (Pharmacologic Class)
Vincristine (Compound) downregulates BRCA1 (Gene)
Vincristine (Compound) causes Respiratory distress (Side Effect)
Vincristine (Compound) binds TUBB2A (Gene) and Vincristine (Compound) upregulates TUBB2A (Gene)