DDInter1946 DDInter1376
Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms. Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Voriconazole {u} (Compound) binds {v} (Gene) CYP2B6
Voriconazole {u} (Compound) upregulates {v} (Gene) SELL
Voriconazole {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 2C9 Inhibitors
Voriconazole {u} (Compound) causes {v} (Side Effect) Arthralgia
Voriconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Voriconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Voriconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Avatrombopag
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Voriconazole {u} may lead to a major life threatening interaction when taken with {v} Acetohexamide
Voriconazole (Compound) binds CYP2B6 (Gene)
Voriconazole (Compound) upregulates SELL (Gene)
Voriconazole (Compound) is included by Cytochrome P450 2C9 Inhibitors (Pharmacologic Class)
Voriconazole (Compound) causes Arthralgia (Side Effect)
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Avatrombopag
Voriconazole may lead to a major life threatening interaction when taken with Dasatinib
Voriconazole may lead to a major life threatening interaction when taken with Acetohexamide