DDInter576 DDInter411
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being first patented in 1960 and then released for sale from Roche in the US in 1975,[T469,T472] clonazepam has experienced a storied history in the treatment of the aforementioned medical conditions. Now available as a generic medication, the agent continues to see exceptionally high use as millions of prescriptions are written for the medication internationally every year. Unfortunately, however, like most benzodiazepines, clonazepam use has also been associated with recreational use and drug abuse.[FDA Label][L5572,F3763,F3787,F3796]
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clonazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Clonazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nitrazepam
Nitrazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Nitrazepam
Nitrazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Diazepam
Diazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Lassitude
Lassitude {u} (Side Effect) is caused by {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) resembles {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Clonazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Diazepam
Diazepam {u} (Compound) resembles {v} (Compound) Clonazepam
Disulfiram {u} (Compound) binds {v} (Gene) DBH
DBH {u} (Gene) is associated with {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Clonazepam
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Clonazepam
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clonazepam (Compound)
Disulfiram (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Clonazepam (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nitrazepam (Compound) and Nitrazepam (Compound) resembles Clonazepam (Compound)
Disulfiram (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Nitrazepam (Compound) and Nitrazepam (Compound) resembles Clonazepam (Compound)
Disulfiram (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Diazepam (Compound) and Diazepam (Compound) resembles Clonazepam (Compound)
Disulfiram (Compound) causes Lassitude (Side Effect) and Lassitude (Side Effect) is caused by Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) resembles panic disorder (Disease) and panic disorder (Disease) is palliated by Clonazepam (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diazepam (Compound) and Diazepam (Compound) resembles Clonazepam (Compound)
Disulfiram (Compound) binds DBH (Gene) and DBH (Gene) is associated with Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Clonazepam (Compound)
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is associated with CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Clonazepam (Compound)