DDInter690 DDInter1314
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can also be used to treat moderate acne vulgaris.[L11845,L11848] Norgestimate was granted FDA approval on 29 December 1989.
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Norgestimate
Ethanol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Griseofulvin
Griseofulvin {u} may lead to a major life threatening interaction when taken with {v} Norgestimate
Ethanol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestimate
Ethanol {u} (Compound) binds {v} (Gene) GRIN3A
GRIN3A {u} (Gene) regulates {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Norgestimate
Ethanol {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Norgestimate
Ethanol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dabrafenib
Dabrafenib {u} may lead to a major life threatening interaction when taken with {v} Norgestimate
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Testosterone (Compound) and Testosterone (Compound) resembles Norgestimate (Compound)
Ethanol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Griseofulvin (Compound) and Griseofulvin may lead to a major life threatening interaction when taken with Norgestimate
Ethanol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Rosuvastatin (Compound) and Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norgestimate
Ethanol (Compound) binds GRIN3A (Gene) and GRIN3A (Gene) regulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Norgestimate (Compound)
Ethanol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Norgestimate (Compound)
Ethanol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound) and Dabrafenib may lead to a major life threatening interaction when taken with Norgestimate