DDInter717 DDInter1082
Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712, A214715] Fenfluramine is a serotonergic phenethylamine originally used as an appetite suppressant until concerns regarding cardiotoxicity in obese patients lead to its withdrawal from the market in 1997.[A214694, A214718, A11906] Through its ability to modulate neurotransmission, fenfluramine has reemerged as an effective therapy against pharmacoresistant seizures, such as those involved in Dravet syndrome.[A214688, A214691, A214700] Fenfluramine was granted initial FDA approval in 1973 prior to its withdrawal
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Fenfluramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Fenfluramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eliglustat
Fenfluramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eptifibatide
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Phendimetrazine
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Fluvoxamine
Fenfluramine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eptifibatide
Fenfluramine may lead to a major life threatening interaction when taken with Phendimetrazine
Fenfluramine may lead to a major life threatening interaction when taken with Fluvoxamine