DDInter1233 DDInter1442
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Mitotane {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Mitotane {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Mitotane {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Methsuximide {u} (Compound) resembles {v} (Compound) Phenobarbital
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Mitotane {u} (Compound) resembles {v} (Compound) Chlorcyclizine
Chlorcyclizine {u} (Compound) resembles {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Mitotane {u} (Compound) causes {v} (Side Effect) Lethargy
Lethargy {u} (Side Effect) is caused by {v} (Compound) Lomustine
Lomustine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Letrozole
Letrozole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Mitotane {u} (Compound) resembles {v} (Compound) Econazole
Econazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Mitotane (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Phenobarbital (Compound)
Mitotane (Compound) resembles Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Mitotane (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Phenobarbital (Compound)
Mitotane (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Methsuximide (Compound) and Methsuximide (Compound) resembles Phenobarbital (Compound)
Mitotane (Compound) resembles Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Mitotane (Compound) resembles Chlorcyclizine (Compound) and Chlorcyclizine (Compound) resembles Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Mitotane (Compound) causes Lethargy (Side Effect) and Lethargy (Side Effect) is caused by Lomustine (Compound) and Lomustine may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Letrozole (Compound) and Letrozole may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Mitotane (Compound) resembles Econazole (Compound) and Econazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenobarbital (Compound)