DDInter458 DDInter1043
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well.[L44052,T862]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levacetylmethadol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disopyramide
Disopyramide {u} (Compound) resembles {v} (Compound) Levacetylmethadol
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Disopyramide
Disopyramide {u} (Compound) resembles {v} (Compound) Levacetylmethadol
Cyclosporine {u} (Compound) downregulates {v} (Gene) BACE2
BACE2 {u} (Gene) is upregulated by {v} (Compound) Disopyramide
Disopyramide {u} (Compound) resembles {v} (Compound) Levacetylmethadol
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levacetylmethadol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levacetylmethadol
Cyclosporine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Disopyramide
Disopyramide {u} (Compound) resembles {v} (Compound) Levacetylmethadol
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Pazopanib {u} may lead to a major life threatening interaction when taken with {v} Levacetylmethadol
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Levacetylmethadol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may lead to a major life threatening interaction when taken with {v} Levacetylmethadol
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levacetylmethadol (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disopyramide (Compound) and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Disopyramide (Compound) and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Cyclosporine (Compound) downregulates BACE2 (Gene) and BACE2 (Gene) is upregulated by Disopyramide (Compound) and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol
Cyclosporine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Disopyramide (Compound) and Disopyramide (Compound) resembles Levacetylmethadol (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Pazopanib (Compound) and Pazopanib may lead to a major life threatening interaction when taken with Levacetylmethadol
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Tamoxifen (Compound) and Tamoxifen (Compound) resembles Levacetylmethadol (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Levacetylmethadol
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Cimetidine (Compound) and Cimetidine may lead to a major life threatening interaction when taken with Levacetylmethadol