DDInter1042 DDInter987
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and cardiac output, without vasoconstriction.[A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline]. Isoprenaline was granted FDA approval on 19 February 1948.
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylephrine
Isoprenaline {u} (Compound) resembles {v} (Compound) Hexoprenaline
Isoprenaline {u} (Compound) resembles {v} (Compound) Isoetharine
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levonordefrin
Isoprenaline {u} (Compound) treats {v} (Disease) asthma
Isoprenaline {u} (Compound) binds {v} (Gene) PIK3R2
Isoprenaline {u} (Compound) upregulates {v} (Gene) DHX29
Isoprenaline {u} (Compound) downregulates {v} (Gene) COG2
Isoprenaline {u} (Compound) causes {v} (Side Effect) Flushing
Isoprenaline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ciclesonide
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine
Isoprenaline (Compound) resembles Hexoprenaline (Compound)
Isoprenaline (Compound) resembles Isoetharine (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin
Isoprenaline (Compound) treats asthma (Disease)
Isoprenaline (Compound) binds PIK3R2 (Gene)
Isoprenaline (Compound) upregulates DHX29 (Gene)
Isoprenaline (Compound) downregulates COG2 (Gene)
Isoprenaline (Compound) causes Flushing (Side Effect)
Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Ciclesonide