DDInter1448 DDInter1798
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including the treatment of hypertensive episodes, prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and treatment of pharmacologically-induced mydriasis.[L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and topically.
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Thiothixene
Phentolamine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Thiothixene
Phentolamine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Olopatadine
Olopatadine {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propiomazine
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Thiothixene (Compound)
Phentolamine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Thiothixene (Compound)
Phentolamine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Thiothixene (Compound)
Phentolamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Thiothixene (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Olopatadine (Compound) and Olopatadine (Compound) resembles Thiothixene (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Doxepin (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)