DDInter1276 DDInter1938
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Nelfinavir {u} may lead to a major life threatening interaction when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Nelfinavir {u} may lead to a major life threatening interaction when taken with {v} Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Nelfinavir {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Vincristine
Nelfinavir {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is downregulated by {v} (Compound) Vincristine
Nelfinavir {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Vincristine
Nelfinavir {u} may lead to a major life threatening interaction when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Voacamine
Voacamine {u} (Compound) resembles {v} (Compound) Vincristine
Nelfinavir {u} may lead to a major life threatening interaction when taken with {v} Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Nelfinavir {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is downregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Nelfinavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Nelfinavir {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) TUBA4A
TUBA4A {u} (Gene) is bound by {v} (Compound) Vincristine
Nelfinavir may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Nelfinavir may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine (Compound) resembles Vincristine (Compound)
Nelfinavir (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Vincristine (Compound)
Nelfinavir (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is downregulated by Vincristine (Compound)
Nelfinavir (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Vincristine (Compound)
Nelfinavir may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine (Compound) resembles Voacamine (Compound) and Voacamine (Compound) resembles Vincristine (Compound)
Nelfinavir may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Nelfinavir (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is downregulated by colon cancer (Disease) and colon cancer (Disease) is treated by Vincristine (Compound)
Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinorelbine (Compound) and Vinorelbine (Compound) resembles Vincristine (Compound)
Nelfinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates TUBA4A (Gene) and TUBA4A (Gene) is bound by Vincristine (Compound)