DDInter1875 DDInter875
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and self-assembled into VLPs.
Trimetrexate {u} (Compound) resembles {v} (Compound) Trimethoprim
Trimetrexate {u} (Compound) binds {v} (Gene) DHFR
Trimetrexate {u} (Compound) causes {v} (Side Effect) Hyponatraemia
Trimetrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Trimetrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alefacept
Trimetrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tuberculin purified protein derivative
Trimetrexate {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Trimetrexate {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Trimetrexate (Compound) resembles Trimethoprim (Compound)
Trimetrexate (Compound) binds DHFR (Gene)
Trimetrexate (Compound) causes Hyponatraemia (Side Effect)
Trimetrexate may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Alefacept
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Trimetrexate may lead to a major life threatening interaction when taken with Mipomersen
Trimetrexate may lead to a major life threatening interaction when taken with Clozapine