DDInter1939 DDInter1956
Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting. A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug.
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) binds {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) binds {v} (Gene) TUBB6
TUBB6 {u} (Gene) is upregulated by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Vinorelbine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is upregulated by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Vinorelbine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Zalcitabine (Compound)
Vinorelbine (Compound) binds TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Zalcitabine (Compound)
Vinorelbine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Zalcitabine (Compound)
Vinorelbine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Zalcitabine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cytarabine (Compound) and Cytarabine (Compound) resembles Zalcitabine (Compound)
Vinorelbine (Compound) binds TUBB6 (Gene) and TUBB6 (Gene) is upregulated by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Vinorelbine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is upregulated by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)