DDInter458 DDInter638
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that suppresses the renin-angiotensin-aldosterone system to lower blood pressure. It was developed from a targeted research programmed using molecular modelling. Being a prodrug, enalapril is rapidly biotransformed into its active metabolite, [enalaprilat], which is responsible for the pharmacological actions of enalapril. The active metabolite of enalapril competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the renin-angiotensin-aldosterone system that promotes vasoconstriction and renal reabsorption of sodium ions in the kidneys. Ultimately, enalaprilat works to reduce blood pressure and blood fluid volume. Commonly marketed under the trade name Vasotec, enalapril was first approved by the FDA in 1985 for the management of hypertension, heart failure, and asymptomatic left ventricular dysfunction. It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension. The active metabolite enalaprilat is also available in oral tablets and intravenous formulations for injection.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Enalapril
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is upregulated by {v} (Compound) Enalapril
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Enalapril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Serum creatinine increased
Serum creatinine increased {u} (Side Effect) is caused by {v} (Compound) Enalapril
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Captopril
Captopril {u} (Compound) resembles {v} (Compound) Enalapril
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Lisinopril
Lisinopril {u} (Compound) resembles {v} (Compound) Enalapril
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enalapril
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Enalapril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Serum creatinine increased
Serum creatinine increased {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Enalapril (Compound)
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is upregulated by Enalapril (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Enalapril (Compound)
Cyclosporine (Compound) causes Serum creatinine increased (Side Effect) and Serum creatinine increased (Side Effect) is caused by Enalapril (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Captopril (Compound) and Captopril (Compound) resembles Enalapril (Compound)
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Enalapril
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lisinopril (Compound) and Lisinopril (Compound) resembles Enalapril (Compound)
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is upregulated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Enalapril
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Enalapril (Compound)
Cyclosporine (Compound) causes Serum creatinine increased (Side Effect) and Serum creatinine increased (Side Effect) is caused by Fosinopril (Compound) and Fosinopril (Compound) resembles Enalapril (Compound)