DDInter948 DDInter608
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence. Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.
Duloxetine {u} (Compound) resembles {v} (Compound) Atomoxetine
Duloxetine {u} (Compound) binds {v} (Gene) CYP1A2
Duloxetine {u} (Compound) upregulates {v} (Gene) HMOX1
Duloxetine {u} (Compound) palliates {v} (Disease) bipolar disorder
Duloxetine {u} (Compound) is included by {v} (Pharmacologic Class) Norepinephrine Uptake Inhibitors
Duloxetine {u} (Compound) downregulates {v} (Gene) CDCA4
Duloxetine {u} (Compound) causes {v} (Side Effect) Acute liver injury
Duloxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Esomeprazole
Duloxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pantoprazole
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Duloxetine (Compound) resembles Atomoxetine (Compound)
Duloxetine (Compound) binds CYP1A2 (Gene)
Duloxetine (Compound) upregulates HMOX1 (Gene)
Duloxetine (Compound) palliates bipolar disorder (Disease)
Duloxetine (Compound) is included by Norepinephrine Uptake Inhibitors (Pharmacologic Class)
Duloxetine (Compound) downregulates CDCA4 (Gene)
Duloxetine (Compound) causes Acute liver injury (Side Effect)
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Esomeprazole
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Pantoprazole
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123