DDInter1037 DDInter1662
Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the substitution of leucine for isoleucine at position 1 (N-terminal end). Lepirudin is used as an anticoagulant in patients with heparin-induced thrombocytopenia (HIT), an immune reaction associated with a high risk of thromboembolic complications.[A3, L41539] HIT is caused by the expression of immunoglobulin G (IgG) antibodies that bind to the complex formed by heparin and
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ticagrelor
Ticagrelor {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ticagrelor
Ticagrelor {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} (Compound) downregulates {v} (Gene) CSRP1
CSRP1 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clomipramine
Clomipramine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Treprostinil {u} (Compound) downregulates {v} (Gene) NSDHL
NSDHL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vitamin E
Vitamin E {u} (Compound) binds {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexfenfluramine
Dexfenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) downregulates NSDHL (Gene) and NSDHL (Gene) is upregulated by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E (Compound) binds HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)