DDInter350 DDInter906
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Chlorambucil {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Ifosfamide
Chlorambucil {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Ifosfamide
Chlorambucil {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ifosfamide
Chlorambucil {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) resembles {v} (Disease) germ cell cancer
germ cell cancer {u} (Disease) is treated by {v} (Compound) Ifosfamide
Chlorambucil {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) upregulates {v} (Gene) NNT
NNT {u} (Gene) is upregulated by {v} (Compound) Ifosfamide
Chlorambucil {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Mitomycin
Mitomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ifosfamide
Chlorambucil {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Trovafloxacin
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ifosfamide
Chlorambucil {u} (Compound) causes {v} (Side Effect) Lung fibrosis interstitial
Lung fibrosis interstitial {u} (Side Effect) is caused by {v} (Compound) Carmustine
Carmustine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ifosfamide
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ifosfamide
Chlorambucil (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Ifosfamide (Compound)
Chlorambucil (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Ifosfamide (Compound)
Chlorambucil (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Chlorambucil (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) resembles germ cell cancer (Disease) and germ cell cancer (Disease) is treated by Ifosfamide (Compound)
Chlorambucil (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) upregulates NNT (Gene) and NNT (Gene) is upregulated by Ifosfamide (Compound)
Chlorambucil (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Mitomycin (Compound) and Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Chlorambucil (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Trovafloxacin (Compound) and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Ifosfamide
Chlorambucil (Compound) causes Lung fibrosis interstitial (Side Effect) and Lung fibrosis interstitial (Side Effect) is caused by Carmustine (Compound) and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide