DDInter1340 DDInter54
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse effects are generally related to the sedation it can cause. Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. Alprazolam was given FDA approval on October 16, 1981.
Omeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Alprazolam
Omeprazole {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Alprazolam
Omeprazole {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Alprazolam
Omeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Estazolam
Estazolam {u} (Compound) resembles {v} (Compound) Alprazolam
Omeprazole {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is downregulated by {v} (Compound) Alprazolam
Omeprazole {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Diazepam
Diazepam {u} (Compound) resembles {v} (Compound) Alprazolam
Omeprazole {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Alprazolam
Omeprazole {u} (Compound) causes {v} (Side Effect) Menstrual disorder
Menstrual disorder {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alprazolam
Omeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Alprazolam
Omeprazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Temazepam
Temazepam {u} (Compound) resembles {v} (Compound) Alprazolam
Omeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alprazolam (Compound)
Omeprazole (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Alprazolam (Compound)
Omeprazole (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Alprazolam (Compound)
Omeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Estazolam (Compound) and Estazolam (Compound) resembles Alprazolam (Compound)
Omeprazole (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregulated by Alprazolam (Compound)
Omeprazole (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Diazepam (Compound) and Diazepam (Compound) resembles Alprazolam (Compound)
Omeprazole (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Alprazolam (Compound)
Omeprazole (Compound) causes Menstrual disorder (Side Effect) and Menstrual disorder (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam
Omeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Alprazolam (Compound)
Omeprazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Temazepam (Compound) and Temazepam (Compound) resembles Alprazolam (Compound)