DDInter704 DDInter1398
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.
Everolimus {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Pasireotide
Everolimus {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Terlipressin
Terlipressin {u} (Compound) resembles {v} (Compound) Pasireotide
Everolimus {u} (Compound) causes {v} (Side Effect) Hypercholesterolaemia
Hypercholesterolaemia {u} (Side Effect) is caused by {v} (Compound) Carvedilol
Carvedilol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pasireotide
Everolimus {u} (Compound) causes {v} (Side Effect) Nasopharyngitis
Nasopharyngitis {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pasireotide
Everolimus {u} (Compound) causes {v} (Side Effect) Blood glucose increased
Blood glucose increased {u} (Side Effect) is caused by {v} (Compound) Lurasidone
Lurasidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pasireotide
Everolimus {u} (Compound) causes {v} (Side Effect) Blood glucose increased
Blood glucose increased {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may lead to a major life threatening interaction when taken with {v} Pasireotide
Everolimus {u} (Compound) causes {v} (Side Effect) Cholelithiasis
Cholelithiasis {u} (Side Effect) is caused by {v} (Compound) Rilpivirine
Rilpivirine {u} may lead to a major life threatening interaction when taken with {v} Pasireotide
Everolimus {u} (Compound) upregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) interacts with {v} (Gene) SSTR3
SSTR3 {u} (Gene) is bound by {v} (Compound) Pasireotide
Everolimus {u} (Compound) upregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pasireotide
Everolimus {u} (Compound) downregulates {v} (Gene) PRMT5
PRMT5 {u} (Gene) interacts with {v} (Gene) SSTR1
SSTR1 {u} (Gene) is bound by {v} (Compound) Pasireotide
Everolimus (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Everolimus (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Terlipressin (Compound) and Terlipressin (Compound) resembles Pasireotide (Compound)
Everolimus (Compound) causes Hypercholesterolaemia (Side Effect) and Hypercholesterolaemia (Side Effect) is caused by Carvedilol (Compound) and Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide
Everolimus (Compound) causes Nasopharyngitis (Side Effect) and Nasopharyngitis (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pasireotide
Everolimus (Compound) causes Blood glucose increased (Side Effect) and Blood glucose increased (Side Effect) is caused by Lurasidone (Compound) and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide
Everolimus (Compound) causes Blood glucose increased (Side Effect) and Blood glucose increased (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may lead to a major life threatening interaction when taken with Pasireotide
Everolimus (Compound) causes Cholelithiasis (Side Effect) and Cholelithiasis (Side Effect) is caused by Rilpivirine (Compound) and Rilpivirine may lead to a major life threatening interaction when taken with Pasireotide
Everolimus (Compound) upregulates HSPA1A (Gene) and HSPA1A (Gene) interacts with SSTR3 (Gene) and SSTR3 (Gene) is bound by Pasireotide (Compound)
Everolimus (Compound) upregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide
Everolimus (Compound) downregulates PRMT5 (Gene) and PRMT5 (Gene) interacts with SSTR1 (Gene) and SSTR1 (Gene) is bound by Pasireotide (Compound)