DDInter458 DDInter1620
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is upregulated by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) downregulates {v} (Gene) FASTKD5
FASTKD5 {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CYB561
CYB561 {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urinary tract infection
Urinary tract infection {u} (Side Effect) is caused by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is regulated by {v} (Gene) PTK2
PTK2 {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) downregulates {v} (Gene) FASTKD5
FASTKD5 {u} (Gene) regulates {v} (Gene) S100A6
S100A6 {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) regulates {v} (Gene) INPP4B
INPP4B {u} (Gene) is upregulated by {v} (Compound) Ropivacaine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CYB561
CYB561 {u} (Gene) regulates {v} (Gene) NSDHL
NSDHL {u} (Gene) is downregulated by {v} (Compound) Ropivacaine
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ropivacaine (Compound)
Cyclosporine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is upregulated by Ropivacaine (Compound)
Cyclosporine (Compound) downregulates FASTKD5 (Gene) and FASTKD5 (Gene) is downregulated by Ropivacaine (Compound)
Cyclosporine (Compound) upregulates CYB561 (Gene) and CYB561 (Gene) is downregulated by Ropivacaine (Compound)
Cyclosporine (Compound) causes Urinary tract infection (Side Effect) and Urinary tract infection (Side Effect) is caused by Ropivacaine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lidocaine (Compound) and Lidocaine (Compound) resembles Ropivacaine (Compound)
Cyclosporine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is regulated by PTK2 (Gene) and PTK2 (Gene) is downregulated by Ropivacaine (Compound)
Cyclosporine (Compound) downregulates FASTKD5 (Gene) and FASTKD5 (Gene) regulates S100A6 (Gene) and S100A6 (Gene) is downregulated by Ropivacaine (Compound)
Cyclosporine (Compound) downregulates CD320 (Gene) and CD320 (Gene) regulates INPP4B (Gene) and INPP4B (Gene) is upregulated by Ropivacaine (Compound)
Cyclosporine (Compound) upregulates CYB561 (Gene) and CYB561 (Gene) regulates NSDHL (Gene) and NSDHL (Gene) is downregulated by Ropivacaine (Compound)