DDInter906 DDInter1960
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Ifosfamide {u} (Compound) treats {v} (Disease) testicular cancer
Ifosfamide {u} (Compound) binds {v} (Gene) CYP2A6
Ifosfamide {u} (Compound) upregulates {v} (Gene) UBQLN2
Ifosfamide {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Ifosfamide {u} (Compound) downregulates {v} (Gene) STUB1
Ifosfamide {u} (Compound) causes {v} (Side Effect) Palpitations
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Ifosfamide (Compound) treats testicular cancer (Disease)
Ifosfamide (Compound) binds CYP2A6 (Gene)
Ifosfamide (Compound) upregulates UBQLN2 (Gene)
Ifosfamide (Compound) is included by Alkylating Activity (Pharmacologic Class)
Ifosfamide (Compound) downregulates STUB1 (Gene)
Ifosfamide (Compound) causes Palpitations (Side Effect)
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Quazepam