DDInter219 DDInter255
A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Bleomycin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) causes {v} (Side Effect) Cystitis haemorrhagic
Cystitis haemorrhagic {u} (Side Effect) is caused by {v} (Compound) Busulfan
Bleomycin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Bleomycin {u} (Compound) treats {v} (Disease) melanoma
melanoma {u} (Disease) is associated with {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) treats {v} (Disease) melanoma
melanoma {u} (Disease) is associated with {v} (Gene) TERT
TERT {u} (Gene) is upregulated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) binds {v} (Gene) BLMH
BLMH {u} (Gene) is regulated by {v} (Gene) CASP7
CASP7 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) treats {v} (Disease) melanoma
melanoma {u} (Disease) upregulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) binds {v} (Gene) LIG3
LIG3 {u} (Gene) interacts with {v} (Gene) ABL1
ABL1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) binds {v} (Gene) BLMH
BLMH {u} (Gene) regulates {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Bleomycin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) WASF3
WASF3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Bleomycin (Compound) causes Cystitis haemorrhagic (Side Effect) and Cystitis haemorrhagic (Side Effect) is caused by Busulfan (Compound)
Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Bleomycin (Compound) treats melanoma (Disease) and melanoma (Disease) is associated with GDF15 (Gene) and GDF15 (Gene) is downregulated by Busulfan (Compound)
Bleomycin (Compound) treats melanoma (Disease) and melanoma (Disease) is associated with TERT (Gene) and TERT (Gene) is upregulated by Busulfan (Compound)
Bleomycin (Compound) binds BLMH (Gene) and BLMH (Gene) is regulated by CASP7 (Gene) and CASP7 (Gene) is downregulated by Busulfan (Compound)
Bleomycin (Compound) treats melanoma (Disease) and melanoma (Disease) upregulates TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Busulfan (Compound)
Bleomycin (Compound) binds LIG3 (Gene) and LIG3 (Gene) interacts with ABL1 (Gene) and ABL1 (Gene) is upregulated by Busulfan (Compound)
Bleomycin (Compound) binds BLMH (Gene) and BLMH (Gene) regulates PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates WASF3 (Gene) and WASF3 (Gene) is upregulated by Busulfan (Compound)