DDInter358 DDInter881
Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of chloroprocaine is characterized by a short latency and duration, similar to the one observed with [lidocaine]. Chloroprocaine can be given as an injection, and is available in formulations with and without methylparaben as a preservative. Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks.[A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 for ocular surface anesthesia.
Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue. Hyaluronidase has been used in surgical settings for at least the past 60 years to improve the diffusion of local anesthetics. Hyaluronidase was first used in prescription products in the United States on 5 May 2004.
Chloroprocaine {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Oxybuprocaine
Oxybuprocaine {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Prilocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} (Compound) resembles {v} (Compound) Mepivacaine
Mepivacaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Mepyramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Prilocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Dexamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine {u} (Compound) binds {v} (Gene) BCHE
BCHE {u} (Gene) is bound by {v} (Compound) Procaine
Procaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chloroprocaine (Compound) resembles Procaine (Compound) and Procaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Oxybuprocaine (Compound) and Oxybuprocaine (Compound) resembles Procaine (Compound) and Procaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Lidocaine (Compound) and Lidocaine may lead to a major life threatening interaction when taken with Prilocaine and Prilocaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide (Compound) resembles Procaine (Compound) and Procaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Lidocaine (Compound) and Lidocaine (Compound) resembles Mepivacaine (Compound) and Mepivacaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Prilocaine and Prilocaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) resembles Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chloroprocaine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Procaine (Compound) and Procaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase