DDInter542 DDInter576
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) binds {v} (Gene) GPR35
GPR35 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) resembles {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) interacts with {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) binds {v} (Gene) GPR35
GPR35 {u} (Gene) regulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) is regulated by {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) interacts with {v} (Gene) FIS1
FIS1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) DNAJB1
DNAJB1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) regulates {v} (Gene) ICMT
ICMT {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Disulfiram (Compound)
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Disulfiram (Compound)
Dicoumarol (Compound) binds GPR35 (Gene) and GPR35 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Disulfiram (Compound)
Dicoumarol (Compound) resembles Acenocoumarol (Compound) and Acenocoumarol (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) interacts with HSPA1A (Gene) and HSPA1A (Gene) is upregulated by Disulfiram (Compound)
Dicoumarol (Compound) binds GPR35 (Gene) and GPR35 (Gene) regulates ABHD4 (Gene) and ABHD4 (Gene) is upregulated by Disulfiram (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) is regulated by HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Disulfiram (Compound)
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) interacts with FIS1 (Gene) and FIS1 (Gene) is downregulated by Disulfiram (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) interacts with DNAJB1 (Gene) and NQO1 (Gene) regulates DNAJB1 (Gene) and DNAJB1 (Gene) is upregulated by Disulfiram (Compound)
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) regulates ICMT (Gene) and ICMT (Gene) is downregulated by Disulfiram (Compound)