DDInter110 DDInter535
Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Apraclonidine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) resembles {v} (Compound) Clonidine
Clonidine {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) resembles {v} (Compound) Tizanidine
Tizanidine {u} (Compound) downregulates {v} (Gene) USP22
USP22 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) resembles {v} (Compound) Clonidine
Clonidine {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) resembles {v} (Compound) Brimonidine
Brimonidine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) treats {v} (Disease) glaucoma
glaucoma {u} (Disease) is associated with {v} (Gene) CDKN1B
CDKN1B {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) binds {v} (Gene) ADRA2B
ADRA2B {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) treats {v} (Disease) glaucoma
glaucoma {u} (Disease) is associated with {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Apraclonidine {u} (Compound) binds {v} (Gene) ADRA2C
ADRA2C {u} (Gene) regulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Apraclonidine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Apraclonidine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Apraclonidine (Compound) resembles Clonidine (Compound) and Clonidine (Compound) treats hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Apraclonidine (Compound) resembles Tizanidine (Compound) and Tizanidine (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Diazoxide (Compound)
Apraclonidine (Compound) resembles Clonidine (Compound) and Clonidine (Compound) downregulates CAST (Gene) and CAST (Gene) is downregulated by Diazoxide (Compound)
Apraclonidine (Compound) resembles Brimonidine (Compound) and Brimonidine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Diazoxide (Compound)
Apraclonidine (Compound) treats glaucoma (Disease) and glaucoma (Disease) is associated with CDKN1B (Gene) and CDKN1B (Gene) is downregulated by Diazoxide (Compound)
Apraclonidine (Compound) binds ADRA2B (Gene) and ADRA2B (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Apraclonidine (Compound) treats glaucoma (Disease) and glaucoma (Disease) is associated with CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Apraclonidine (Compound) binds ADRA2C (Gene) and ADRA2C (Gene) regulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)