DDInter252 DDInter1631
Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. More specifically, bupropion binds to the norepinephrine transporter (NET) and the dopamine transporter (DAT).[A6399,A178810] Bupropion was originally classified as an "atypical" antidepressant because it does not exert the same effects as the classical antidepressants such as Monoamine Oxidase Inhibitors (MA
Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Bupropion {u} (Compound) treats {v} (Disease) obesity
Bupropion {u} (Compound) binds {v} (Gene) CYP2C8
Bupropion {u} (Compound) upregulates {v} (Gene) GPER1
Bupropion {u} (Compound) palliates {v} (Disease) attention deficit hyperactivity disorder
Bupropion {u} (Compound) is included by {v} (Pharmacologic Class) Increased Norepinephrine Activity
Bupropion {u} (Compound) downregulates {v} (Gene) HDAC6
Bupropion {u} (Compound) causes {v} (Side Effect) Female sexual arousal disorder
Bupropion {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prasugrel
Bupropion {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxazosin
Bupropion (Compound) treats obesity (Disease)
Bupropion (Compound) binds CYP2C8 (Gene)
Bupropion (Compound) upregulates GPER1 (Gene)
Bupropion (Compound) palliates attention deficit hyperactivity disorder (Disease)
Bupropion (Compound) is included by Increased Norepinephrine Activity (Pharmacologic Class)
Bupropion (Compound) downregulates HDAC6 (Gene)
Bupropion (Compound) causes Female sexual arousal disorder (Side Effect)
Bupropion may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Bupropion may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Doxazosin