DDInter458 DDInter1327
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib is used to treat a number of BRCA-associated tumours, including ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.[L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014, and by Health Canada in April 2016.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) is upregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) downregulates {v} (Gene) LIG1
LIG1 {u} (Gene) is upregulated by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) is bound by {v} (Compound) Verapamil
Verapamil {u} may lead to a major life threatening interaction when taken with {v} Olaparib
Cyclosporine {u} (Compound) downregulates {v} (Gene) LIG1
LIG1 {u} (Gene) is downregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) upregulates {v} (Gene) WDR45
WDR45 {u} (Gene) is upregulated by {v} (Compound) Crizotinib
Crizotinib {u} may lead to a major life threatening interaction when taken with {v} Olaparib
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Simvastatin
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) downregulates {v} (Gene) LIG1
LIG1 {u} (Gene) is bound by {v} (Compound) Bleomycin
Bleomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Cyclosporine {u} (Compound) downregulates {v} (Gene) RPS6KA1
RPS6KA1 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may lead to a major life threatening interaction when taken with {v} Olaparib
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is upregulated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is upregulated by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is bound by Verapamil (Compound) and Verapamil may lead to a major life threatening interaction when taken with Olaparib
Cyclosporine (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is downregulated by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) upregulates WDR45 (Gene) and WDR45 (Gene) is upregulated by Crizotinib (Compound) and Crizotinib may lead to a major life threatening interaction when taken with Olaparib
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Simvastatin (Compound) and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is bound by Bleomycin (Compound) and Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Cyclosporine (Compound) downregulates RPS6KA1 (Gene) and RPS6KA1 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may lead to a major life threatening interaction when taken with Olaparib