DDInter1447 DDInter1397
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Phentermine {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is bound by {v} (Compound) Paroxetine
Phentermine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Phentermine {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is associated with {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Inappropriate antidiuretic hormone secretion
Inappropriate antidiuretic hormone secretion {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Pseudoephedrine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Paroxetine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Paroxetine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Phentermine {u} (Compound) resembles {v} (Compound) Tolazoline
Tolazoline {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Phentermine {u} (Compound) resembles {v} (Compound) Phenformin
Phenformin {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Phentermine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Paroxetine (Compound)
Phentermine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Paroxetine (Compound)
Phentermine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is associated with panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)
Phentermine (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Phentermine (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) causes Inappropriate antidiuretic hormone secretion (Side Effect) and Inappropriate antidiuretic hormone secretion (Side Effect) is caused by Paroxetine (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Paroxetine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Paroxetine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Paroxetine (Compound)
Phentermine (Compound) resembles Tolazoline (Compound) and Tolazoline (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Paroxetine (Compound)
Phentermine (Compound) resembles Phenformin (Compound) and Phenformin (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is downregulated by Paroxetine (Compound)