DDInter150 DDInter806
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Azathioprine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleoside Analog
Nucleoside Analog {u} (Pharmacologic Class) includes {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) causes {v} (Side Effect) Vasculitis
Vasculitis {u} (Side Effect) is caused by {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleoside Analog
Nucleoside Analog {u} (Pharmacologic Class) includes {v} (Compound) Penciclovir
Penciclovir {u} (Compound) resembles {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Penciclovir
Penciclovir {u} (Compound) resembles {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) causes {v} (Side Effect) Vasculitis
Vasculitis {u} (Side Effect) is caused by {v} (Compound) Acyclovir
Acyclovir {u} (Compound) resembles {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Valganciclovir
Valganciclovir {u} (Compound) resembles {v} (Compound) Ganciclovir
Azathioprine {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Azathioprine {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Tioguanine
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Azathioprine (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Ganciclovir (Compound)
Azathioprine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ganciclovir (Compound)
Azathioprine (Compound) causes Vasculitis (Side Effect) and Vasculitis (Side Effect) is caused by Ganciclovir (Compound)
Azathioprine (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Penciclovir (Compound) and Penciclovir (Compound) resembles Ganciclovir (Compound)
Azathioprine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Penciclovir (Compound) and Penciclovir (Compound) resembles Ganciclovir (Compound)
Azathioprine (Compound) causes Vasculitis (Side Effect) and Vasculitis (Side Effect) is caused by Acyclovir (Compound) and Acyclovir (Compound) resembles Ganciclovir (Compound)
Azathioprine (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Valganciclovir (Compound) and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Azathioprine (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir
Azathioprine (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir
Azathioprine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Tioguanine (Compound) and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir