DDInter1453 DDInter1376
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Phenylephrine {u} (Compound) resembles {v} (Compound) Epinephrine
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Phenylephrine {u} (Compound) resembles {v} (Compound) Metaraminol
Phenylephrine {u} (Compound) binds {v} (Gene) ADRA1B
Phenylephrine {u} (Compound) is included by {v} (Pharmacologic Class) Adrenergic alpha1-Agonists
Phenylephrine {u} (Compound) causes {v} (Side Effect) Eye irritation
Phenylephrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lithium carbonate
Phenylephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentermine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Ergometrine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Methylergometrine
Phenylephrine (Compound) resembles Epinephrine (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Phenylephrine (Compound) resembles Metaraminol (Compound)
Phenylephrine (Compound) binds ADRA1B (Gene)
Phenylephrine (Compound) is included by Adrenergic alpha1-Agonists (Pharmacologic Class)
Phenylephrine (Compound) causes Eye irritation (Side Effect)
Phenylephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine
Phenylephrine may lead to a major life threatening interaction when taken with Ergometrine
Phenylephrine may lead to a major life threatening interaction when taken with Methylergometrine