DDInter1253 DDInter1397
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as active as Δ⁹-THC. Nabilone is approved by the FDA for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction with cannabinoid receptors that are
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Nabilone {u} (Compound) causes {v} (Side Effect) Lightheadedness
Lightheadedness {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Nabilone {u} (Compound) resembles {v} (Compound) Dronabinol
Dronabinol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alfuzosin
Alfuzosin {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) downregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Nabilone {u} (Compound) resembles {v} (Compound) Dronabinol
Dronabinol {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alfuzosin
Alfuzosin {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trichlormethiazide
Trichlormethiazide {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) upregulates {v} (Gene) VAPB
VAPB {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethosuximide
Ethosuximide {u} (Compound) causes {v} (Side Effect) Malnutrition
Malnutrition {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Nabilone (Compound) causes Lightheadedness (Side Effect) and Lightheadedness (Side Effect) is caused by Paroxetine (Compound)
Nabilone (Compound) resembles Dronabinol (Compound) and Dronabinol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Alfuzosin and Alfuzosin (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) downregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Paroxetine (Compound)
Nabilone (Compound) resembles Dronabinol (Compound) and Dronabinol (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Alfuzosin and Alfuzosin (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) upregulates VAPB (Gene) and VAPB (Gene) is downregulated by Paroxetine (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Ethosuximide and Ethosuximide (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Paroxetine (Compound)