DDInter1768 DDInter1008
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Terbinafine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) binds {v} (Gene) SQLE
SQLE {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) downregulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) is downregulated by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) binds {v} (Gene) CYP11A1
CYP11A1 {u} (Gene) interacts with {v} (Gene) CYP11B2
CYP11B2 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) binds {v} (Gene) SQLE
SQLE {u} (Gene) interacts with {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is regulated by {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Ketoconazole
Terbinafine {u} (Compound) downregulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) is regulated by {v} (Gene) FDFT1
FDFT1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Terbinafine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketoconazole (Compound)
Terbinafine (Compound) binds SQLE (Gene) and SQLE (Gene) is upregulated by Ketoconazole (Compound)
Terbinafine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Ketoconazole (Compound)
Terbinafine (Compound) downregulates PPP2R3C (Gene) and PPP2R3C (Gene) is downregulated by Ketoconazole (Compound)
Terbinafine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Ketoconazole (Compound)
Terbinafine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Terbinafine (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) interacts with CYP11B2 (Gene) and CYP11B2 (Gene) is bound by Ketoconazole (Compound)
Terbinafine (Compound) binds SQLE (Gene) and SQLE (Gene) interacts with ALDOC (Gene) and ALDOC (Gene) is upregulated by Ketoconazole (Compound)
Terbinafine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is regulated by AR (Gene) and AR (Gene) is bound by Ketoconazole (Compound)
Terbinafine (Compound) downregulates PPP2R3C (Gene) and PPP2R3C (Gene) is regulated by FDFT1 (Gene) and FDFT1 (Gene) is upregulated by Ketoconazole (Compound)