DDInter885 DDInter1658
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone was granted FDA approval on 5 August 1952.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Hydrocortisone {u} (Compound) resembles {v} (Compound) Loteprednol
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eplerenone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Hydrocortisone {u} (Compound) treats {v} (Disease) gout
Hydrocortisone {u} (Compound) binds {v} (Gene) CYP11B1
Hydrocortisone {u} (Compound) upregulates {v} (Gene) PRKCD
Hydrocortisone {u} (Compound) palliates {v} (Disease) prostate cancer
Hydrocortisone {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Hydrocortisone {u} (Compound) downregulates {v} (Gene) AMIGO2
Hydrocortisone {u} (Compound) causes {v} (Side Effect) Papilloedema
Hydrocortisone (Compound) resembles Loteprednol (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Hydrocortisone (Compound) resembles Fludrocortisone (Compound)
Hydrocortisone (Compound) treats gout (Disease)
Hydrocortisone (Compound) binds CYP11B1 (Gene)
Hydrocortisone (Compound) upregulates PRKCD (Gene)
Hydrocortisone (Compound) palliates prostate cancer (Disease)
Hydrocortisone (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Hydrocortisone (Compound) downregulates AMIGO2 (Gene)
Hydrocortisone (Compound) causes Papilloedema (Side Effect)