DDInter624 DDInter900
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID. On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Ibuprofen
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Baclofen
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Vesiculobullous rash
Vesiculobullous rash {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Metyrosine
Metyrosine {u} (Compound) resembles {v} (Compound) Ibuprofen
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) BCL2
BCL2 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Creatinine increased
Creatinine increased {u} (Side Effect) is caused by {v} (Compound) Vancomycin
Vancomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Eruption
Eruption {u} (Side Effect) is caused by {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Efavirenz (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ibuprofen (Compound)
Efavirenz (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Efavirenz (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Efavirenz (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Efavirenz (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Baclofen (Compound) and Baclofen (Compound) resembles Ibuprofen (Compound)
Efavirenz (Compound) causes Vesiculobullous rash (Side Effect) and Vesiculobullous rash (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Efavirenz (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Metyrosine (Compound) and Metyrosine (Compound) resembles Ibuprofen (Compound)
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates BCL2 (Gene) and BCL2 (Gene) is bound by Ibuprofen (Compound)
Efavirenz (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Vancomycin (Compound) and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Efavirenz (Compound) causes Eruption (Side Effect) and Eruption (Side Effect) is caused by Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen