DDInter1804 DDInter178
Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Clopidogrel
Ticlopidine {u} (Compound) binds {v} (Gene) MPO
Ticlopidine {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Platelet Aggregation
Ticlopidine {u} (Compound) downregulates {v} (Gene) RPS4Y1
Ticlopidine {u} (Compound) causes {v} (Side Effect) Flatulence
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alteplase
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Stiripentol
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Drotrecogin alfa
Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Ticlopidine (Compound) binds MPO (Gene)
Ticlopidine (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class)
Ticlopidine (Compound) downregulates RPS4Y1 (Gene)
Ticlopidine (Compound) causes Flatulence (Side Effect)
Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Turmeric
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Alteplase
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Ticlopidine may lead to a major life threatening interaction when taken with Drotrecogin alfa