DDInter395 DDInter1747
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Clemastine {u} (Compound) resembles {v} (Compound) Eletriptan
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Clemastine {u} (Compound) resembles {v} (Compound) Mesoridazine
Clemastine {u} (Compound) binds {v} (Gene) CYP3A4
Clemastine {u} (Compound) upregulates {v} (Gene) INSIG1
Clemastine {u} (Compound) downregulates {v} (Gene) IKBKAP
Clemastine {u} (Compound) causes {v} (Side Effect) Chest tightness
Clemastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Clemastine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Clemastine (Compound) resembles Eletriptan (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clemastine (Compound) resembles Mesoridazine (Compound)
Clemastine (Compound) binds CYP3A4 (Gene)
Clemastine (Compound) upregulates INSIG1 (Gene)
Clemastine (Compound) downregulates IKBKAP (Gene)
Clemastine (Compound) causes Chest tightness (Side Effect)
Clemastine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trospium
Clemastine may lead to a major life threatening interaction when taken with Zonisamide