DDInter1666 DDInter1639
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Sildenafil {u} (Compound) downregulates {v} (Gene) CD44
CD44 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) downregulates {v} (Gene) CD44
CD44 {u} (Gene) regulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is associated with {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) downregulates {v} (Gene) IGFBP2
IGFBP2 {u} (Gene) regulates {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is regulated by {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) regulates {v} (Gene) SATB1
SATB1 {u} (Gene) is upregulated by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is regulated by {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Sildenafil (Compound) downregulates CD44 (Gene) and CD44 (Gene) is downregulated by Sapropterin (Compound)
Sildenafil (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Sapropterin (Compound)
Sildenafil (Compound) downregulates CD44 (Gene) and CD44 (Gene) regulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Sapropterin (Compound)
Sildenafil (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is associated with NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)
Sildenafil (Compound) downregulates IGFBP2 (Gene) and IGFBP2 (Gene) regulates NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)
Sildenafil (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sapropterin (Compound)
Sildenafil (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is regulated by PTGS2 (Gene) and PTGS2 (Gene) is bound by Sapropterin (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) regulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Sapropterin (Compound)
Sildenafil (Compound) downregulates CYCS (Gene) and CYCS (Gene) is regulated by RNH1 (Gene) and RNH1 (Gene) is downregulated by Sapropterin (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by RNH1 (Gene) and RNH1 (Gene) is downregulated by Sapropterin (Compound)