DDInter576 DDInter544
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
A dideoxynucleoside compound in which the 3&#39;-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Didanosine
Disulfiram {u} (Compound) causes {v} (Side Effect) Sensory loss
Sensory loss {u} (Side Effect) is caused by {v} (Compound) Didanosine
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is regulated by {v} (Gene) PNP
PNP {u} (Gene) is bound by {v} (Compound) Didanosine
Disulfiram {u} (Compound) causes {v} (Side Effect) Sensory loss
Sensory loss {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy peripheral
Neuropathy peripheral {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Disulfiram {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Entecavir
Entecavir {u} (Compound) resembles {v} (Compound) Didanosine
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Disulfiram {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Entecavir
Entecavir {u} (Compound) resembles {v} (Compound) Didanosine
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is regulated by {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Didanosine
Disulfiram {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Ranitidine
Ranitidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Didanosine
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Didanosine (Compound)
Disulfiram (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Didanosine (Compound)
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is regulated by PNP (Gene) and PNP (Gene) is bound by Didanosine (Compound)
Disulfiram (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Didanosine
Disulfiram (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Zalcitabine (Compound) and Zalcitabine (Compound) resembles Didanosine (Compound)
Disulfiram (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Entecavir (Compound) and Entecavir (Compound) resembles Didanosine (Compound)
Disulfiram (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Didanosine
Disulfiram (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Entecavir (Compound) and Entecavir (Compound) resembles Didanosine (Compound)
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is regulated by NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Didanosine (Compound)
Disulfiram (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Ranitidine (Compound) and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Didanosine