DDInter458 DDInter1179
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) In the US, methoxyflurane is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pentamidine
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLT1B
GOLT1B {u} (Gene) is regulated by {v} (Gene) ATP2C1
ATP2C1 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Cyclosporine {u} (Compound) downregulates {v} (Gene) HDAC2
HDAC2 {u} (Gene) is regulated by {v} (Gene) ATP2C1
ATP2C1 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Epinephrine
Epinephrine {u} may lead to a major life threatening interaction when taken with {v} Methoxyflurane
Cyclosporine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Cyclosporine {u} (Compound) downregulates {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) regulates {v} (Gene) ATP2C1
ATP2C1 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Cyclosporine {u} (Compound) downregulates {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Methoxyflurane
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Methoxyflurane (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pentamidine (Compound) and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Cyclosporine (Compound) upregulates GOLT1B (Gene) and GOLT1B (Gene) is regulated by ATP2C1 (Gene) and ATP2C1 (Gene) is bound by Methoxyflurane (Compound)
Cyclosporine (Compound) downregulates HDAC2 (Gene) and HDAC2 (Gene) is regulated by ATP2C1 (Gene) and ATP2C1 (Gene) is bound by Methoxyflurane (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Epinephrine (Compound) and Epinephrine may lead to a major life threatening interaction when taken with Methoxyflurane
Cyclosporine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Clofarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Cyclosporine (Compound) downregulates HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) regulates ATP2C1 (Gene) and ATP2C1 (Gene) is bound by Methoxyflurane (Compound)
Cyclosporine (Compound) downregulates HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Methoxyflurane