DDInter1263 DDInter1956
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Naltrexone {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Naltrexone {u} (Compound) causes {v} (Side Effect) Colitis
Colitis {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Naltrexone {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Naltrexone {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Naltrexone {u} (Compound) causes {v} (Side Effect) Haemorrhoids
Haemorrhoids {u} (Side Effect) is caused by {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Naltrexone {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Zalcitabine
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Zalcitabine (Compound)
Naltrexone (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Zalcitabine (Compound)
Naltrexone (Compound) causes Colitis (Side Effect) and Colitis (Side Effect) is caused by Zalcitabine (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Naltrexone (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Naltrexone (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Naltrexone (Compound) causes Haemorrhoids (Side Effect) and Haemorrhoids (Side Effect) is caused by Decitabine (Compound) and Decitabine (Compound) resembles Zalcitabine (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Decitabine (Compound) and Decitabine (Compound) resembles Zalcitabine (Compound)
Naltrexone (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by DCK (Gene) and DCK (Gene) is bound by Zalcitabine (Compound)