DDInter1542 DDInter105
Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Protein C (APC). Once in its activated form, APC functions as a serine protease with potent anticoagulant effects, especially in the presence of its cofactor protein S. APC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot formation. The Protein C pathway provides a natural mechanism for control of the coagulation system and prevention of excessive procoagulant responses to activating stimuli. A lack of protein
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Protein C {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Danaparoid
Protein C {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Selumetinib
Protein C {u} may lead to a major life threatening interaction when taken with {v} Caplacizumab
Protein C may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Protein C may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Protein C may lead to a major life threatening interaction when taken with Caplacizumab