DDInter1254 DDInter105
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Nabumetone {u} (Compound) resembles {v} (Compound) Melatonin
Nabumetone {u} (Compound) binds {v} (Gene) MPO
Nabumetone {u} (Compound) palliates {v} (Disease) osteoarthritis
Nabumetone {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nabumetone {u} (Compound) downregulates {v} (Gene) DNAJA3
Nabumetone {u} (Compound) causes {v} (Side Effect) Pruritus
Nabumetone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Nabumetone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Nabumetone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alteplase
Nabumetone (Compound) resembles Naproxen (Compound)
Nabumetone (Compound) resembles Melatonin (Compound)
Nabumetone (Compound) binds MPO (Gene)
Nabumetone (Compound) palliates osteoarthritis (Disease)
Nabumetone (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Nabumetone (Compound) downregulates DNAJA3 (Gene)
Nabumetone (Compound) causes Pruritus (Side Effect)
Nabumetone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Alteplase