DDInter1431 DDInter856
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Perindopril {u} (Compound) resembles {v} (Compound) Trandolapril
Perindopril {u} (Compound) resembles {v} (Compound) Quinapril
Perindopril {u} (Compound) treats {v} (Disease) coronary artery disease
Perindopril {u} (Compound) binds {v} (Gene) ACE
Perindopril {u} (Compound) upregulates {v} (Gene) SATB1
Perindopril {u} (Compound) downregulates {v} (Gene) HAT1
Perindopril {u} (Compound) causes {v} (Side Effect) Muscular weakness
Perindopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium carbonate
Perindopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Erythropoietin
Perindopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epoprostenol
Perindopril (Compound) resembles Trandolapril (Compound)
Perindopril (Compound) resembles Quinapril (Compound)
Perindopril (Compound) treats coronary artery disease (Disease)
Perindopril (Compound) binds ACE (Gene)
Perindopril (Compound) upregulates SATB1 (Gene)
Perindopril (Compound) downregulates HAT1 (Gene)
Perindopril (Compound) causes Muscular weakness (Side Effect)
Perindopril may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Perindopril may cause a minor interaction that can limit clinical effects when taken with Erythropoietin
Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol