DDInter957 DDInter821
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder in which the overproduction of toxic heme intermediates leads to neuro-, nephro-, and gastrotoxicity. Givosiran represents an important step forward in the treatment of acute hepatic porphyria as it is the first approved pharmacotherapy for the prevention of acute attacks - previous strategies involved non-therapeutic measures (e.g. trigger avoidance), intravenous [hemin] for the treatment of attacks, and liver transplantation in refractory cases. Givosiran is the second-ever FDA-approved member of the siRNA drug class (the first being [patisiran]), a new class of drugs promising an important and exciting step forward in the treatment of genetic disorders.
Iodipamide {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Gefitinib
Gefitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Givosiran
Iodipamide {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iohexol
Iohexol {u} may lead to a major life threatening interaction when taken with {v} Givosiran
Iodipamide {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Givosiran
Iodipamide {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Acyclovir
Acyclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Givosiran
Iodipamide {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Iohexol
Iohexol {u} may lead to a major life threatening interaction when taken with {v} Givosiran
Iodipamide {u} (Compound) causes {v} (Side Effect) Feeling hot
Feeling hot {u} (Side Effect) is caused by {v} (Compound) Iodixanol
Iodixanol {u} may lead to a major life threatening interaction when taken with {v} Givosiran
Iodipamide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Iodipamide (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iohexol (Compound) and Iohexol may lead to a major life threatening interaction when taken with Givosiran
Iodipamide (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Iodipamide (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Acyclovir (Compound) and Acyclovir may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Iodipamide (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Iohexol (Compound) and Iohexol may lead to a major life threatening interaction when taken with Givosiran
Iodipamide (Compound) causes Feeling hot (Side Effect) and Feeling hot (Side Effect) is caused by Iodixanol (Compound) and Iodixanol may lead to a major life threatening interaction when taken with Givosiran