DDInter1811 DDInter782
A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections.
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form of netupitant [FDA label]. Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting as major side effects. Considered one of the most distressing side effects of chemotherapy, nausea and vomiting has an immense impact on the quality of life of patients receiving certain antineoplastic therapies .
Tinidazole {u} (Compound) resembles {v} (Compound) Metronidazole
Tinidazole {u} (Compound) binds {v} (Gene) CYP3A4
Tinidazole {u} (Compound) upregulates {v} (Gene) FOXO4
Tinidazole {u} (Compound) is included by {v} (Pharmacologic Class) Nitroimidazoles
Tinidazole {u} (Compound) downregulates {v} (Gene) IGFBP2
Tinidazole {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Tinidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Tinidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethambutol
Tinidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cabazitaxel
Tinidazole {u} may lead to a major life threatening interaction when taken with {v} Amprenavir
Tinidazole (Compound) resembles Metronidazole (Compound)
Tinidazole (Compound) binds CYP3A4 (Gene)
Tinidazole (Compound) upregulates FOXO4 (Gene)
Tinidazole (Compound) is included by Nitroimidazoles (Pharmacologic Class)
Tinidazole (Compound) downregulates IGFBP2 (Gene)
Tinidazole (Compound) causes Stevens-Johnson syndrome (Side Effect)
Tinidazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Tinidazole may lead to a major life threatening interaction when taken with Amprenavir