DDInter1397 DDInter1533
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Paroxetine {u} (Compound) binds {v} (Gene) CHRM2
CHRM2 {u} (Gene) is bound by {v} (Compound) Promethazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Promethazine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM2
CHRM2 {u} (Gene) is bound by {v} (Compound) Ethopropazine
Ethopropazine {u} (Compound) resembles {v} (Compound) Promethazine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM3
CHRM3 {u} (Gene) is bound by {v} (Compound) Propiomazine
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) resembles {v} (Compound) Promethazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Promethazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Paroxetine {u} (Compound) upregulates {v} (Gene) MSMO1
MSMO1 {u} (Gene) is upregulated by {v} (Compound) Ethopropazine
Ethopropazine {u} (Compound) resembles {v} (Compound) Promethazine
Paroxetine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Promethazine (Compound)
Paroxetine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Promethazine (Compound)
Paroxetine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Ethopropazine (Compound) and Ethopropazine (Compound) resembles Promethazine (Compound)
Paroxetine (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Promethazine (Compound)
Paroxetine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Paroxetine (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Diltiazem (Compound) and Diltiazem (Compound) resembles Promethazine (Compound)
Paroxetine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Paroxetine (Compound) upregulates MSMO1 (Gene) and MSMO1 (Gene) is upregulated by Ethopropazine (Compound) and Ethopropazine (Compound) resembles Promethazine (Compound)