DDInter596 DDInter1156
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Doxorubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Doxorubicin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Mercaptopurine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Candida infection
Candida infection {u} (Side Effect) is caused by {v} (Compound) Mercaptopurine
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Doxorubicin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Doxorubicin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Candida infection
Candida infection {u} (Side Effect) is caused by {v} (Compound) Trovafloxacin
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Oral candidiasis
Oral candidiasis {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Myelosuppression
Myelosuppression {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Doxorubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Doxorubicin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Mercaptopurine (Compound)
Doxorubicin (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Mercaptopurine (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Doxorubicin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Methotrexate (Compound) and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Doxorubicin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Doxorubicin (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Trovafloxacin (Compound) and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Doxorubicin (Compound) causes Oral candidiasis (Side Effect) and Oral candidiasis (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Doxorubicin (Compound) causes Myelosuppression (Side Effect) and Myelosuppression (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine