DDInter336 DDInter105
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Celecoxib {u} (Compound) binds {v} (Gene) CA14
Celecoxib {u} (Compound) upregulates {v} (Gene) ST3GAL5
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Celecoxib {u} (Compound) downregulates {v} (Gene) TUBB2B
Celecoxib {u} (Compound) causes {v} (Side Effect) Nausea
Celecoxib (Compound) resembles Sulfaphenazole (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound)
Celecoxib (Compound) binds CA14 (Gene)
Celecoxib (Compound) upregulates ST3GAL5 (Gene)
Celecoxib (Compound) palliates osteoarthritis (Disease)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Celecoxib (Compound) downregulates TUBB2B (Gene)
Celecoxib (Compound) causes Nausea (Side Effect)