DDInter781 DDInter1406
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine. FDA approved March 27, 2012.
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Moexipril
Moexipril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Trandolapril
Trandolapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) resembles {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) binds {v} (Gene) SLC15A1
SLC15A1 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) resembles {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Quinapril
Quinapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) causes {v} (Side Effect) Serum creatinine increased
Serum creatinine increased {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Fosinopril {u} (Compound) causes {v} (Side Effect) Serum creatinine increased
Serum creatinine increased {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Peginesatide
Fosinopril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) resembles Moexipril (Compound) and Moexipril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) resembles Enalapril (Compound) and Enalapril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) resembles Cilazapril (Compound) and Cilazapril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) binds SLC15A1 (Gene) and SLC15A1 (Gene) is bound by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) resembles Cilazapril (Compound) and Cilazapril (Compound) resembles Quinapril (Compound) and Quinapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) causes Serum creatinine increased (Side Effect) and Serum creatinine increased (Side Effect) is caused by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Fosinopril (Compound) causes Serum creatinine increased (Side Effect) and Serum creatinine increased (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Peginesatide