DDInter576 DDInter1033
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Losartan
Losartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Disulfiram {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) ACOT9
ACOT9 {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) PTK2B
PTK2B {u} (Gene) is bound by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) interacts with {v} (Gene) CREB1
CREB1 {u} (Gene) is upregulated by {v} (Compound) Leflunomide
Disulfiram {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Disulfiram {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Disulfiram (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Leflunomide (Compound)
Disulfiram (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Leflunomide (Compound)
Disulfiram (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Leflunomide (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Losartan (Compound) and Losartan may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Disulfiram (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates ACOT9 (Gene) and ACOT9 (Gene) is downregulated by Leflunomide (Compound)
Disulfiram (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates PTK2B (Gene) and PTK2B (Gene) is bound by Leflunomide (Compound)
Disulfiram (Compound) downregulates DLD (Gene) and DLD (Gene) interacts with CREB1 (Gene) and CREB1 (Gene) is upregulated by Leflunomide (Compound)
Disulfiram (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Isotretinoin (Compound) and Isotretinoin may lead to a major life threatening interaction when taken with Leflunomide
Disulfiram (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Telbivudine (Compound) and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide