DDInter1918 DDInter1676
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum. PDE5 inhibitors, such as vardenafil, inhibit the degradation of cGMP and allow increased blood flow into the penis, resulting in an erection.[A258303,L45563,L45568]. Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil. The FDA approved the use of v
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Vardenafil {u} (Compound) resembles {v} (Compound) Sildenafil
Vardenafil {u} (Compound) resembles {v} (Compound) Udenafil
Vardenafil {u} (Compound) binds {v} (Gene) CYP3A4
Vardenafil {u} (Compound) upregulates {v} (Gene) ABCC5
Vardenafil {u} (Compound) downregulates {v} (Gene) RNH1
Vardenafil {u} (Compound) causes {v} (Side Effect) Amnesia
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palonosetron
Vardenafil {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Vardenafil {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Vardenafil (Compound) resembles Sildenafil (Compound)
Vardenafil (Compound) resembles Udenafil (Compound)
Vardenafil (Compound) binds CYP3A4 (Gene)
Vardenafil (Compound) upregulates ABCC5 (Gene)
Vardenafil (Compound) downregulates RNH1 (Gene)
Vardenafil (Compound) causes Amnesia (Side Effect)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron
Vardenafil may lead to a major life threatening interaction when taken with Hydroxychloroquine
Vardenafil may lead to a major life threatening interaction when taken with Cisapride