DDInter1230 DDInter1055
Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy.[A178144,L6160] In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions. It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Mirtazapine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) causes {v} (Side Effect) Euphoric mood
Euphoric mood {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) resembles {v} (Compound) Mianserin
Mianserin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) binds {v} (Gene) HTR2C
HTR2C {u} (Gene) regulates {v} (Gene) HTATSF1
HTATSF1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) resembles {v} (Compound) Mianserin
Mianserin {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is associated with {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Mirtazapine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) regulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Mirtazapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Mirtazapine (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Levofloxacin (Compound)
Mirtazapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Levofloxacin (Compound)
Mirtazapine (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Mirtazapine (Compound) causes Euphoric mood (Side Effect) and Euphoric mood (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Mirtazapine (Compound) resembles Mianserin (Compound) and Mianserin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Mirtazapine (Compound) binds HTR2C (Gene) and HTR2C (Gene) regulates HTATSF1 (Gene) and HTATSF1 (Gene) is downregulated by Levofloxacin (Compound)
Mirtazapine (Compound) resembles Mianserin (Compound) and Mianserin (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Levofloxacin (Compound)
Mirtazapine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is associated with chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)
Mirtazapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) regulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Levofloxacin (Compound)