DDInter1524 DDInter1055
A derivative of procaine with less CNS action.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Procainamide {u} (Compound) binds {v} (Gene) SLC22A2
SLC22A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Procainamide {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Procainamide {u} (Compound) binds {v} (Gene) SLC22A4
SLC22A4 {u} (Gene) is bound by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Procainamide {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Procainamide {u} (Compound) resembles {v} (Compound) Aminohippurate
Aminohippurate {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Procainamide {u} (Compound) binds {v} (Gene) SLC22A4
SLC22A4 {u} (Gene) regulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Procainamide {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Procainamide {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Procainamide {u} (Compound) binds {v} (Gene) SLC22A4
SLC22A4 {u} (Gene) regulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Procainamide {u} (Compound) resembles {v} (Compound) Probenecid
Probenecid {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Procainamide (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Levofloxacin (Compound)
Procainamide (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Levofloxacin (Compound)
Procainamide (Compound) binds SLC22A4 (Gene) and SLC22A4 (Gene) is bound by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Procainamide (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Procainamide (Compound) resembles Aminohippurate (Compound) and Aminohippurate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Procainamide (Compound) binds SLC22A4 (Gene) and SLC22A4 (Gene) regulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Levofloxacin (Compound)
Procainamide (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Procainamide (Compound) resembles Procaine (Compound) and Procaine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Levofloxacin (Compound)
Procainamide (Compound) binds SLC22A4 (Gene) and SLC22A4 (Gene) regulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)
Procainamide (Compound) resembles Probenecid (Compound) and Probenecid (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)