DDInter1826 DDInter393
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Tolazamide {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Tolazamide {u} (Compound) causes {v} (Side Effect) Abdominal distension
Abdominal distension {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Tolazamide {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Roxithromycin
Roxithromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Tolazamide {u} (Compound) causes {v} (Side Effect) Abdominal distension
Abdominal distension {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Tolazamide {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Erythromycin
Erythromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Tolazamide {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Azithromycin
Azithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Tolazamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) resembles {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Tolazamide {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is regulated by {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Tolazamide (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Clarithromycin (Compound)
Tolazamide (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Clarithromycin (Compound)
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Tolazamide (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Roxithromycin (Compound) and Roxithromycin (Compound) resembles Clarithromycin (Compound)
Tolazamide (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Tolazamide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Erythromycin (Compound) and Erythromycin (Compound) resembles Clarithromycin (Compound)
Tolazamide (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Azithromycin (Compound) and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clarithromycin (Compound)
Tolazamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Tolazamide (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is regulated by CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compound)