DDInter596 DDInter192
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Bepridil
Doxorubicin {u} (Compound) upregulates {v} (Gene) TNNC1
TNNC1 {u} (Gene) is bound by {v} (Compound) Bepridil
Doxorubicin {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Bepridil
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Bepridil
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bepridil
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Bepridil
Doxorubicin {u} (Compound) upregulates {v} (Gene) TNNC1
TNNC1 {u} (Gene) covaries with {v} (Gene) CALM1
CALM1 {u} (Gene) is bound by {v} (Compound) Bepridil
Doxorubicin {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bepridil
Doxorubicin {u} (Compound) causes {v} (Side Effect) Rhinitis
Rhinitis {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Bepridil
Doxorubicin {u} (Compound) causes {v} (Side Effect) Ventricular arrhythmia
Ventricular arrhythmia {u} (Side Effect) is caused by {v} (Compound) Granisetron
Granisetron {u} may lead to a major life threatening interaction when taken with {v} Bepridil
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound)
Doxorubicin (Compound) upregulates TNNC1 (Gene) and TNNC1 (Gene) is bound by Bepridil (Compound)
Doxorubicin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bepridil (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Bepridil
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Bepridil
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Bepridil (Compound)
Doxorubicin (Compound) upregulates TNNC1 (Gene) and TNNC1 (Gene) covaries with CALM1 (Gene) and CALM1 (Gene) is bound by Bepridil (Compound)
Doxorubicin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Bepridil
Doxorubicin (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Bepridil (Compound)
Doxorubicin (Compound) causes Ventricular arrhythmia (Side Effect) and Ventricular arrhythmia (Side Effect) is caused by Granisetron (Compound) and Granisetron may lead to a major life threatening interaction when taken with Bepridil