DDInter1230 DDInter1016
Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy.[A178144,L6160] In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions. It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Mirtazapine {u} (Compound) resembles {v} (Compound) Mianserin
Mirtazapine {u} (Compound) resembles {v} (Compound) Chlorcyclizine
Mirtazapine {u} (Compound) binds {v} (Gene) HTR2C
Mirtazapine {u} (Compound) upregulates {v} (Gene) AGR2
Mirtazapine {u} (Compound) downregulates {v} (Gene) KIF20A
Mirtazapine {u} (Compound) causes {v} (Side Effect) Cardiomegaly
Mirtazapine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Mirtazapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lapatinib
Mirtazapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mefloquine
Mirtazapine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Mirtazapine (Compound) resembles Mianserin (Compound)
Mirtazapine (Compound) resembles Chlorcyclizine (Compound)
Mirtazapine (Compound) binds HTR2C (Gene)
Mirtazapine (Compound) upregulates AGR2 (Gene)
Mirtazapine (Compound) downregulates KIF20A (Gene)
Mirtazapine (Compound) causes Cardiomegaly (Side Effect)
Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine
Mirtazapine may lead to a major life threatening interaction when taken with Bupropion