DDInter662 DDInter1627
Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolated for the first time from yeast in 1931 and its structure was elucidated in 1932. Ergocalciferol is considered the first vitamin D analog and is differentiated from [cholecalciferol] by the presence of a double bond between C22 and C23 and the presence of a methyl group at C24. These modifications reduce the affinity of ergocalciferol for the vitamin D binding protein resulting in faster clearance, limits its activation, and alters its catabolism. The first approved product containing ergocalciferol under the FDA records was developed by US Pharm Holdings and was FDA approved in 194
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Ergocalciferol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) resembles {v} (Compound) Calcitriol
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) resembles {v} (Compound) Calcipotriol
Calcipotriol {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) resembles {v} (Compound) Calcitriol
Calcitriol {u} (Compound) upregulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) resembles {v} (Compound) Calcitriol
Calcitriol {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Ergocalciferol {u} (Compound) binds {v} (Gene) VDR
VDR {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Ergocalciferol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Cimetidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Ergocalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Polythiazide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Ergocalciferol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Ergocalciferol (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Rufinamide (Compound)
Ergocalciferol (Compound) resembles Calcitriol (Compound) and Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Ergocalciferol (Compound) resembles Calcipotriol (Compound) and Calcipotriol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Ergocalciferol (Compound) resembles Calcitriol (Compound) and Calcitriol (Compound) upregulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Ergocalciferol (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)
Ergocalciferol (Compound) resembles Calcitriol (Compound) and Calcitriol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Ergocalciferol (Compound) binds VDR (Gene) and VDR (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Ergocalciferol may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Rufinamide (Compound)