DDInter150 DDInter1156
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) is bound by {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Tioguanine
Tioguanine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Azathioprine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) resembles {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) resembles {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Azathioprine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) regulates {v} (Gene) SLC29A1
SLC29A1 {u} (Gene) is bound by {v} (Compound) Mercaptopurine
Azathioprine {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Azathioprine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Mercaptopurine (Compound)
Azathioprine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) is bound by Mercaptopurine (Compound)
Azathioprine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mercaptopurine (Compound)
Azathioprine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Tioguanine (Compound) and Tioguanine (Compound) resembles Mercaptopurine (Compound) and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Azathioprine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) resembles ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Mercaptopurine (Compound)
Azathioprine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) resembles Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) is upregulated by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Azathioprine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) regulates SLC29A1 (Gene) and SLC29A1 (Gene) is bound by Mercaptopurine (Compound)
Azathioprine (Compound) binds XDH (Gene) and XDH (Gene) is bound by Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine