DDInter387 DDInter298
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Cisplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) is included by {v} (Pharmacologic Class) Platinum-containing Compounds
Platinum-containing Compounds {u} (Pharmacologic Class) includes {v} (Compound) Carboplatin
Cisplatin {u} (Compound) causes {v} (Side Effect) Venous thrombosis
Venous thrombosis {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) GSTT1
GSTT1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) resembles {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) resembles {v} (Disease) brain cancer
brain cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cisplatin {u} (Compound) binds {v} (Gene) ATP7A
ATP7A {u} (Gene) interacts with {v} (Gene) ATP7B
ATP7B {u} (Gene) is bound by {v} (Compound) Carboplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Methotrexate {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cisplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Carboplatin (Compound)
Cisplatin (Compound) is included by Platinum-containing Compounds (Pharmacologic Class) and Platinum-containing Compounds (Pharmacologic Class) includes Carboplatin (Compound)
Cisplatin (Compound) causes Venous thrombosis (Side Effect) and Venous thrombosis (Side Effect) is caused by Carboplatin (Compound)
Cisplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with GSTT1 (Gene) and GSTT1 (Gene) is bound by Carboplatin (Compound)
Cisplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) resembles testicular cancer (Disease) and testicular cancer (Disease) is treated by Carboplatin (Compound)
Cisplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) resembles brain cancer (Disease) and brain cancer (Disease) is treated by Carboplatin (Compound)
Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Carboplatin (Compound)
Cisplatin (Compound) binds ATP7A (Gene) and ATP7A (Gene) interacts with ATP7B (Gene) and ATP7B (Gene) is bound by Carboplatin (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)