DDInter1725 DDInter358
Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into [mesalazine] and [sulfapyridine], 2 compounds that carry out the main pharmacological activity of sulfasalazine. Sulfasalazine was first used in 1940 for rheumatic polyarthritis, and has been firmly established itself as one fo the most useful disease-modifying antirheumatic drug (DMARD). Compared to the first line treatment of RA like methotrexate, sulfasalazine is almost as efficacious as methotrexate although with slightly less tolerability. However, sulfasalazine has less teratogenic side effects and faster onset of action compared to conventional DMARD. Sulf
Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of chloroprocaine is characterized by a short latency and duration, similar to the one observed with [lidocaine]. Chloroprocaine can be given as an injection, and is available in formulations with and without methylparaben as a preservative. Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks.[A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 for ocular surface anesthesia.
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Oxybuprocaine
Oxybuprocaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Nitrous acid {u} may lead to a major life threatening interaction when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Nitrous acid {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin
Digoxin {u} (Compound) causes {v} (Side Effect) Cardiac arrest
Cardiac arrest {u} (Side Effect) is caused by {v} (Compound) Chloroprocaine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Fosphenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Procaine (Compound) and Procaine (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) resembles Oxybuprocaine (Compound) and Oxybuprocaine (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous acid may lead to a major life threatening interaction when taken with Procaine and Procaine (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Metoclopramide and Metoclopramide (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous acid may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Chloroprocaine (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Chloroprocaine (Compound)
Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Chloroprocaine (Compound)