DDInter1160 DDInter1652
The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Mestranol {u} (Compound) resembles {v} (Compound) Norethisterone
Mestranol {u} (Compound) resembles {v} (Compound) Ethinylestradiol
Mestranol {u} (Compound) binds {v} (Gene) ESR1
Mestranol {u} (Compound) upregulates {v} (Gene) UBQLN2
Mestranol {u} (Compound) is included by {v} (Pharmacologic Class) Estrogen Receptor Agonists
Mestranol {u} (Compound) downregulates {v} (Gene) YBX3
Mestranol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Mestranol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Mestranol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Mestranol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sarilumab
Mestranol (Compound) resembles Norethisterone (Compound)
Mestranol (Compound) resembles Ethinylestradiol (Compound)
Mestranol (Compound) binds ESR1 (Gene)
Mestranol (Compound) upregulates UBQLN2 (Gene)
Mestranol (Compound) is included by Estrogen Receptor Agonists (Pharmacologic Class)
Mestranol (Compound) downregulates YBX3 (Gene)
Mestranol may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Mestranol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone
Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab