DDInter1397 DDInter1768
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) upregulates {v} (Gene) SQLE
SQLE {u} (Gene) is bound by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Hepatic function abnormal {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Terbinafine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Terbinafine
Paroxetine {u} (Compound) upregulates {v} (Gene) SQLE
SQLE {u} (Gene) is bound by {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Terbinafine
Paroxetine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Terbinafine (Compound)
Paroxetine (Compound) upregulates SQLE (Gene) and SQLE (Gene) is bound by Terbinafine (Compound)
Paroxetine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Terbinafine (Compound)
Paroxetine (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Terbinafine (Compound)
Paroxetine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Terbinafine (Compound)
Paroxetine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Terbinafine (Compound)
Paroxetine (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Terbinafine (Compound)
Paroxetine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Terbinafine
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Terbinafine (Compound)
Paroxetine (Compound) upregulates SQLE (Gene) and SQLE (Gene) is bound by Naftifine (Compound) and Naftifine (Compound) resembles Terbinafine (Compound)