DDInter241 DDInter704
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239]
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Bromfenac {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Bromfenac {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Bromfenac {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Bromfenac {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Everolimus
Bromfenac {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Bromfenac {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Bromfenac {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Bromfenac {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Bromfenac {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Tacrolimus
Tacrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Bromfenac {u} (Compound) resembles {v} (Compound) Balsalazide
Balsalazide {u} (Compound) binds {v} (Gene) PPARG
PPARG {u} (Gene) is downregulated by {v} (Compound) Everolimus
Bromfenac may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Bromfenac (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Everolimus (Compound)
Bromfenac (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Everolimus (Compound)
Bromfenac (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Everolimus (Compound)
Bromfenac may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Bromfenac (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Bromfenac (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Bromfenac (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Bromfenac (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Tacrolimus (Compound) and Tacrolimus (Compound) resembles Everolimus (Compound)
Bromfenac (Compound) resembles Balsalazide (Compound) and Balsalazide (Compound) binds PPARG (Gene) and PPARG (Gene) is downregulated by Everolimus (Compound)