DDInter336 DDInter1851
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of depression. A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy. Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters. It was initially granted FDA approval in 1981.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trazodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Trazodone
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Zuclopenthixol
Zuclopenthixol {u} (Compound) resembles {v} (Compound) Trazodone
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Trazodone
Celecoxib {u} (Compound) binds {v} (Gene) ORM1
ORM1 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trazodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Zuclopenthixol
Zuclopenthixol {u} (Compound) resembles {v} (Compound) Trazodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Trazodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Vasculitis
Vasculitis {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trazodone
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trazodone
Celecoxib {u} (Compound) binds {v} (Gene) ORM1
ORM1 {u} (Gene) is bound by {v} (Compound) Abiraterone
Abiraterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trazodone
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trazodone (Compound)
Celecoxib (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Trazodone (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Zuclopenthixol (Compound) and Zuclopenthixol (Compound) resembles Trazodone (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Quetiapine (Compound) and Quetiapine (Compound) resembles Trazodone (Compound)
Celecoxib (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a minor interaction that can limit clinical effects when taken with Trazodone
Celecoxib (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Zuclopenthixol (Compound) and Zuclopenthixol (Compound) resembles Trazodone (Compound)
Celecoxib (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Quetiapine (Compound) and Quetiapine (Compound) resembles Trazodone (Compound)
Celecoxib (Compound) causes Vasculitis (Side Effect) and Vasculitis (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Trazodone
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trazodone (Compound)
Celecoxib (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Abiraterone (Compound) and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Trazodone