DDInter1796 DDInter535
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618). Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Thioridazine {u} (Compound) upregulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) upregulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is regulated by {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) regulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is regulated by {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) downregulates {v} (Gene) ACD
ACD {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) downregulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) regulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Thioridazine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Thioridazine (Compound) upregulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Thioridazine (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Diazoxide (Compound)
Thioridazine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Diazoxide (Compound)
Thioridazine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Thioridazine (Compound) upregulates PRKCQ (Gene) and PRKCQ (Gene) is regulated by KRT19 (Gene) and KRT19 (Gene) is upregulated by Diazoxide (Compound)
Thioridazine (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) regulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Thioridazine (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is regulated by CEBPD (Gene) and CEBPD (Gene) is upregulated by Diazoxide (Compound)
Thioridazine (Compound) downregulates ACD (Gene) and ACD (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Diazoxide (Compound)
Thioridazine (Compound) downregulates HPRT1 (Gene) and HPRT1 (Gene) regulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Diazoxide (Compound)
Thioridazine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)