DDInter336 DDInter496
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Delavirdine
Celecoxib {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Delavirdine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Abiraterone
Abiraterone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Teniposide
Teniposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Celecoxib {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Teniposide
Teniposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Celecoxib {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Celecoxib {u} (Compound) causes {v} (Side Effect) Musculoskeletal stiffness
Musculoskeletal stiffness {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delavirdine
Celecoxib {u} (Compound) causes {v} (Side Effect) Dermatitis exfoliative
Dermatitis exfoliative {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Terbinafine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delavirdine
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Delavirdine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Terbinafine
Terbinafine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delavirdine
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Delavirdine (Compound)
Celecoxib (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound) and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Teniposide (Compound) and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Celecoxib (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Teniposide (Compound) and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Celecoxib (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Celecoxib (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine
Celecoxib (Compound) causes Dermatitis exfoliative (Side Effect) and Dermatitis exfoliative (Side Effect) is caused by Terbinafine (Compound) and Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Delavirdine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Terbinafine (Compound) and Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine