DDInter1619 DDInter601
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. Due to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction with cannabinoid receptors that are found throughout the body . While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms like Dronabinol or ), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers. From a pharmacological perspective, Cannabis' diverse receptor profile explains its potential application for such a wide variety of medical conditions. Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body . The endocannabinoid system is widely distributed throughout the central and peripheral nervous system (via the Cannabinoid Receptors CB1 and CB2) and plays a role in many physiological processes such as inflammation, cardiovascular function, learning, pain, memory, stress and emotional regulation, and the sleep/wake cycle among many others . CB1 receptors are found in both the central and peripheral nervous system, and are most abundant in the hippocampus and amygdala, which are the areas of the brain responsible for short-term memory storage and emotional regulation. CB2 receptors are mainly located in the peripheral nervous system and can be found on lymphoid tissue where they are involved in regulation of immune function .
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dronabinol
Ropinirole {u} (Compound) causes {v} (Side Effect) Sinusitis
Sinusitis {u} (Side Effect) is caused by {v} (Compound) Dronabinol
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Delavirdine
Delavirdine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dronabinol
Ropinirole {u} (Compound) causes {v} (Side Effect) Sinusitis
Sinusitis {u} (Side Effect) is caused by {v} (Compound) Delavirdine
Delavirdine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dronabinol
Ropinirole {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Nabilone
Nabilone {u} (Compound) resembles {v} (Compound) Dronabinol
Ropinirole {u} (Compound) causes {v} (Side Effect) Paranoid reaction
Paranoid reaction {u} (Side Effect) is caused by {v} (Compound) Tiagabine
Tiagabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Ropinirole {u} (Compound) causes {v} (Side Effect) Paranoid reaction
Paranoid reaction {u} (Side Effect) is caused by {v} (Compound) Mirtazapine
Mirtazapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Ropinirole {u} (Compound) causes {v} (Side Effect) Paranoid reaction
Paranoid reaction {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Dronabinol
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronabinol (Compound)
Ropinirole (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Dronabinol (Compound)
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Delavirdine (Compound) and Delavirdine may cause a minor interaction that can limit clinical effects when taken with Dronabinol
Ropinirole (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Delavirdine (Compound) and Delavirdine may cause a minor interaction that can limit clinical effects when taken with Dronabinol
Ropinirole (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Nabilone (Compound) and Nabilone (Compound) resembles Dronabinol (Compound)
Ropinirole (Compound) causes Paranoid reaction (Side Effect) and Paranoid reaction (Side Effect) is caused by Tiagabine (Compound) and Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Ropinirole (Compound) causes Paranoid reaction (Side Effect) and Paranoid reaction (Side Effect) is caused by Mirtazapine (Compound) and Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Ropinirole (Compound) causes Paranoid reaction (Side Effect) and Paranoid reaction (Side Effect) is caused by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Dronabinol