DDInter458 DDInter1831
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Aminohippurate
Aminohippurate {u} (Compound) resembles {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Indomethacin
Indomethacin {u} (Compound) resembles {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Anagrelide
Anagrelide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolmetin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Ketorolac
Ketorolac {u} (Compound) resembles {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Zolpidem
Zolpidem {u} (Compound) resembles {v} (Compound) Tolmetin
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Tolmetin
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Tolmetin (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Tolmetin (Compound)
Cyclosporine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Tolmetin (Compound)
Cyclosporine (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Tolmetin (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Aminohippurate (Compound) and Aminohippurate (Compound) resembles Tolmetin (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Indomethacin (Compound) and Indomethacin (Compound) resembles Tolmetin (Compound)
Cyclosporine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Anagrelide (Compound) and Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin
Cyclosporine (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Ketorolac (Compound) and Ketorolac (Compound) resembles Tolmetin (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zolpidem (Compound) and Zolpidem (Compound) resembles Tolmetin (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with MPO (Gene) and MPO (Gene) is bound by Tolmetin (Compound)