DDInter1362 DDInter1376
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and is also marketed in many European countries for the indication of major depression under trade names like Cincofarm, Levothym, Levotonine, Oxyfan, Telesol, Tript-OH, and Triptum. Several double-blind placebo-controlled clinical trials have demonstrated the effectiveness of 5-HTP in the treatment of depression, though a lack of high quality studies has been noted. More study is needed to determine efficacy in treating depression.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Oxitriptan {u} (Compound) resembles {v} (Compound) L-Phenylalanine
Oxitriptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Oxitriptan {u} may lead to a major life threatening interaction when taken with {v} Procarbazine
Oxitriptan {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Oxitriptan (Compound) resembles L-Phenylalanine (Compound)
Oxitriptan may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Oxitriptan may lead to a major life threatening interaction when taken with Procarbazine
Oxitriptan may lead to a major life threatening interaction when taken with Methylene blue