DDInter195 DDInter535
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Betamethasone {u} (Compound) upregulates {v} (Gene) ATP1A1
ATP1A1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) upregulates {v} (Gene) CASP2
CASP2 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) downregulates {v} (Gene) ACD
ACD {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) upregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) upregulates {v} (Gene) ATP1A1
ATP1A1 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) upregulates {v} (Gene) GLUL
GLUL {u} (Gene) regulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Betamethasone {u} (Compound) upregulates {v} (Gene) CASP2
CASP2 {u} (Gene) is regulated by {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Betamethasone (Compound) upregulates ATP1A1 (Gene) and ATP1A1 (Gene) is bound by Diazoxide (Compound)
Betamethasone (Compound) upregulates CASP2 (Gene) and CASP2 (Gene) is upregulated by Diazoxide (Compound)
Betamethasone (Compound) downregulates ACD (Gene) and ACD (Gene) is downregulated by Diazoxide (Compound)
Betamethasone (Compound) upregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Diazoxide (Compound)
Betamethasone (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Betamethasone (Compound) upregulates ATP1A1 (Gene) and ATP1A1 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Betamethasone (Compound) upregulates GLUL (Gene) and GLUL (Gene) regulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Diazoxide (Compound)
Betamethasone (Compound) upregulates CASP2 (Gene) and CASP2 (Gene) is regulated by RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)