DDInter154 DDInter1747
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Azelastine {u} (Compound) resembles {v} (Compound) Mazindol
Azelastine {u} (Compound) binds {v} (Gene) CYP1A2
Azelastine {u} (Compound) upregulates {v} (Gene) MAL
Azelastine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Azelastine {u} (Compound) downregulates {v} (Gene) CANT1
Azelastine {u} (Compound) causes {v} (Side Effect) Dermatitis contact
Azelastine (Compound) resembles Loxapine (Compound)
Azelastine (Compound) resembles Mazindol (Compound)
Azelastine (Compound) binds CYP1A2 (Gene)
Azelastine (Compound) upregulates MAL (Gene)
Azelastine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Azelastine (Compound) downregulates CANT1 (Gene)
Azelastine (Compound) causes Dermatitis contact (Side Effect)