DDInter809 DDInter832
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Gatifloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Gatifloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Gatifloxacin {u} (Compound) binds {v} (Gene) ALB
Gatifloxacin {u} (Compound) upregulates {v} (Gene) ABCC5
Gatifloxacin {u} (Compound) downregulates {v} (Gene) RPS4Y1
Gatifloxacin {u} (Compound) causes {v} (Side Effect) Gastritis
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mitomycin
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Procarbazine
Gatifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Gatifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ferrous fumarate
Gatifloxacin (Compound) resembles Lomefloxacin (Compound)
Gatifloxacin (Compound) resembles Sparfloxacin (Compound)
Gatifloxacin (Compound) binds ALB (Gene)
Gatifloxacin (Compound) upregulates ABCC5 (Gene)
Gatifloxacin (Compound) downregulates RPS4Y1 (Gene)
Gatifloxacin (Compound) causes Gastritis (Side Effect)
Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Mitomycin
Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate