DDInter522 DDInter596
An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Dexrazoxane {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) causes {v} (Side Effect) Infestation NOS
Infestation NOS {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) causes {v} (Side Effect) Infestation NOS
Infestation NOS {u} (Side Effect) is caused by {v} (Compound) Epirubicin
Epirubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) binds {v} (Gene) TOP2B
TOP2B {u} (Gene) interacts with {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) upregulates {v} (Gene) CNOT4
CNOT4 {u} (Gene) regulates {v} (Gene) LBR
LBR {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) binds {v} (Gene) TOP2B
TOP2B {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Dexrazoxane {u} (Compound) upregulates {v} (Gene) CPVL
CPVL {u} (Gene) is regulated by {v} (Gene) COASY
COASY {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Dexrazoxane (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Doxorubicin (Compound)
Dexrazoxane (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Doxorubicin (Compound)
Dexrazoxane (Compound) binds TOP2A (Gene) and TOP2A (Gene) is bound by Doxorubicin (Compound) and TOP2A (Gene) is downregulated by Doxorubicin (Compound)
Dexrazoxane (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Dexrazoxane (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Epirubicin (Compound) and Epirubicin (Compound) resembles Doxorubicin (Compound)
Dexrazoxane (Compound) binds TOP2B (Gene) and TOP2B (Gene) interacts with TOP2A (Gene) and TOP2A (Gene) is bound by Doxorubicin (Compound) and TOP2A (Gene) is downregulated by Doxorubicin (Compound)
Dexrazoxane (Compound) binds TOP2A (Gene) and TOP2A (Gene) is bound by Daunorubicin (Compound) and TOP2A (Gene) is downregulated by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Dexrazoxane (Compound) upregulates CNOT4 (Gene) and CNOT4 (Gene) regulates LBR (Gene) and LBR (Gene) is downregulated by Doxorubicin (Compound)
Dexrazoxane (Compound) binds TOP2B (Gene) and TOP2B (Gene) is bound by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Dexrazoxane (Compound) upregulates CPVL (Gene) and CPVL (Gene) is regulated by COASY (Gene) and COASY (Gene) is downregulated by Doxorubicin (Compound)