DDInter1233 DDInter583
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia.[L7916,L7937] A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia. Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.
Mitotane {u} (Compound) causes {v} (Side Effect) Dysarthria
Dysarthria {u} (Side Effect) is caused by {v} (Compound) Donepezil
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Donepezil
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Donepezil
Mitotane {u} (Compound) causes {v} (Side Effect) Dysarthria
Dysarthria {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Tetrabenazine {u} (Compound) resembles {v} (Compound) Donepezil
Mitotane {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Doxazosin
Doxazosin {u} (Compound) resembles {v} (Compound) Donepezil
Mitotane {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Zafirlukast
Zafirlukast {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Mitotane {u} (Compound) causes {v} (Side Effect) Aggression
Aggression {u} (Side Effect) is caused by {v} (Compound) Mefloquine
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Donepezil
Mitotane {u} (Compound) resembles {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetrabenazine
Tetrabenazine {u} (Compound) resembles {v} (Compound) Donepezil
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) resembles {v} (Compound) Miconazole
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Mitotane {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Mitotane (Compound) causes Dysarthria (Side Effect) and Dysarthria (Side Effect) is caused by Donepezil (Compound)
Mitotane (Compound) resembles Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil
Mitotane (Compound) causes Dysarthria (Side Effect) and Dysarthria (Side Effect) is caused by Tetrabenazine (Compound) and Tetrabenazine (Compound) resembles Donepezil (Compound)
Mitotane (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Doxazosin (Compound) and Doxazosin (Compound) resembles Donepezil (Compound)
Mitotane (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Zafirlukast (Compound) and Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Donepezil
Mitotane (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Mefloquine (Compound) and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil
Mitotane (Compound) resembles Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine and Tetrabenazine (Compound) resembles Donepezil (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) resembles Miconazole (Compound) and Miconazole may cause a minor interaction that can limit clinical effects when taken with Donepezil
Mitotane (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may cause a minor interaction that can limit clinical effects when taken with Donepezil