DDInter569 DDInter1798
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Diphenhydramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpromazine
Chlorpromazine {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine {u} may lead to a major life threatening interaction when taken with {v} Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine {u} (Compound) binds {v} (Gene) SLC22A1
SLC22A1 {u} (Gene) is bound by {v} (Compound) Thiothixene
Diphenhydramine {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Thiothixene
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Diphenhydramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Olopatadine
Olopatadine {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Diphenhydramine (Compound) resembles Doxepin (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Diphenhydramine (Compound) resembles Amitriptyline (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Thiothixene (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thiothixene (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Thiothixene (Compound)
Diphenhydramine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Thiothixene (Compound)
Diphenhydramine (Compound) binds SLC22A1 (Gene) and SLC22A1 (Gene) is bound by Thiothixene (Compound)
Diphenhydramine (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is palliated by Thiothixene (Compound)
Diphenhydramine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Thiothixene (Compound)
Diphenhydramine (Compound) resembles Doxepin (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Olopatadine (Compound) and Olopatadine (Compound) resembles Thiothixene (Compound)
Diphenhydramine (Compound) resembles Amitriptyline (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Doxepin (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)