DDInter645 DDInter899
Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Enoxaparin {u} (Compound) binds {v} (Gene) SERPINC1
Enoxaparin {u} (Compound) is included by {v} (Pharmacologic Class) Heparin, Low-Molecular-Weight
Enoxaparin {u} (Compound) causes {v} (Side Effect) Epidural haemorrhage
Enoxaparin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Enoxaparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenyl salicylate
Enoxaparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valdecoxib
Enoxaparin {u} may lead to a major life threatening interaction when taken with {v} Dipyridamole
Enoxaparin {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Enoxaparin (Compound) binds SERPINC1 (Gene)
Enoxaparin (Compound) is included by Heparin, Low-Molecular-Weight (Pharmacologic Class)
Enoxaparin (Compound) causes Epidural haemorrhage (Side Effect)
Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Turmeric
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Enoxaparin may lead to a major life threatening interaction when taken with Dipyridamole
Enoxaparin may lead to a major life threatening interaction when taken with Vorapaxar