DDInter1951 DDInter576
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Warfarin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Warfarin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Citalopram
Citalopram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Citalopram
Citalopram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propylthiouracil
Propylthiouracil {u} (Compound) upregulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Citalopram
Citalopram {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Proguanil
Proguanil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Warfarin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Warfarin may cause a minor interaction that can limit clinical effects when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Warfarin may cause a minor interaction that can limit clinical effects when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil and Propylthiouracil (Compound) upregulates NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Disulfiram (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Proguanil and Proguanil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)