DDInter781 DDInter1376
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Fosinopril {u} (Compound) resembles {v} (Compound) Spirapril
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
Fosinopril {u} (Compound) binds {v} (Gene) SLC15A1
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
Fosinopril {u} (Compound) causes {v} (Side Effect) Urticaria
Fosinopril (Compound) resembles Enalapril (Compound)
Fosinopril (Compound) resembles Spirapril (Compound)
Fosinopril (Compound) treats hypertension (Disease)
Fosinopril (Compound) binds SLC15A1 (Gene)
Fosinopril (Compound) upregulates SYNGR3 (Gene)
Fosinopril (Compound) causes Urticaria (Side Effect)