DDInter162 DDInter1197
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Baclofen {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Baclofen {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Baclofen {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Sexual dysfunction {u} (Side Effect) is caused by {v} (Compound) Clonidine
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Baclofen {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} (Compound) resembles {v} (Compound) Metoclopramide
Baclofen {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Dopamine
Dopamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Baclofen {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Sexual dysfunction {u} (Side Effect) is caused by {v} (Compound) Desvenlafaxine
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Baclofen {u} (Compound) causes {v} (Side Effect) Opisthotonus
Opisthotonus {u} (Side Effect) is caused by {v} (Compound) Paliperidone
Paliperidone {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Baclofen (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Baclofen (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)
Baclofen (Compound) causes Sexual dysfunction (Side Effect) and Sexual dysfunction (Side Effect) is caused by Clonidine (Compound) and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Baclofen (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Sunitinib (Compound) and Sunitinib (Compound) resembles Metoclopramide (Compound)
Baclofen (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Dopamine (Compound) and Dopamine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Baclofen (Compound) causes Sexual dysfunction (Side Effect) and Sexual dysfunction (Side Effect) is caused by Desvenlafaxine (Compound) and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Baclofen (Compound) causes Opisthotonus (Side Effect) and Opisthotonus (Side Effect) is caused by Paliperidone (Compound) and Paliperidone may lead to a major life threatening interaction when taken with Metoclopramide
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Metoclopramide (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)