DDInter458 DDInter1228
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications. It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black box warning of hepatoxicity. Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis) have been reported. Due to this serious risk of liver toxicity, mipomersen sodium is only available to patients under the restricted program called Kynamro Risk Evaluation and Mitigation Strategy program.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Regorafenib
Regorafenib {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Regorafenib
Regorafenib {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Stanozolol
Stanozolol {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is upregulated by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) downregulates {v} (Gene) ITGAE
ITGAE {u} (Gene) is downregulated by {v} (Compound) Propylthiouracil
Propylthiouracil {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Sulfasalazine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine {u} (Compound) downregulates {v} (Gene) PLK4
PLK4 {u} (Gene) is bound by {v} (Compound) Pazopanib
Pazopanib {u} may lead to a major life threatening interaction when taken with {v} Mipomersen
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound) and Regorafenib may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound) and Regorafenib may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Stanozolol (Compound) and Stanozolol may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is upregulated by Rosuvastatin (Compound) and Rosuvastatin may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Propylthiouracil (Compound) and Propylthiouracil may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Sulfasalazine (Compound) and Sulfasalazine may lead to a major life threatening interaction when taken with Mipomersen
Cyclosporine (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) is bound by Pazopanib (Compound) and Pazopanib may lead to a major life threatening interaction when taken with Mipomersen