DDInter1133 DDInter150
A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCl.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Mechlorethamine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mechlorethamine {u} (Compound) resembles {v} (Compound) Cyclophosphamide
Cyclophosphamide {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mechlorethamine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mechlorethamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Cinoxacin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mechlorethamine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Mechlorethamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Ofloxacin {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mechlorethamine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mechlorethamine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mechlorethamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Gatifloxacin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mechlorethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Mechlorethamine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Azathioprine (Compound)
Mechlorethamine (Compound) resembles Cyclophosphamide (Compound) and Cyclophosphamide (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Azathioprine (Compound)
Mechlorethamine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Cinoxacin and Cinoxacin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Azathioprine (Compound)
Mechlorethamine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Azathioprine (Compound)
Mechlorethamine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Mechlorethamine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with CYCS (Gene) and CYCS (Gene) is downregulated by Azathioprine (Compound)
Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin and Gatifloxacin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)