DDInter1845 DDInter518
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Dexfenfluramine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Phentermine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Amphetamine
Amphetamine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Tolterodine
Tolterodine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Metamfetamine
Metamfetamine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2A6
CYP2A6 {u} (Gene) is bound by {v} (Compound) Dapagliflozin
Dapagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexfenfluramine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Cinacalcet
Cinacalcet {u} (Compound) resembles {v} (Compound) Dexfenfluramine
Tranylcypromine {u} (Compound) resembles {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Metamfetamine
Metamfetamine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Tranylcypromine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexfenfluramine (Compound)
Tranylcypromine (Compound) resembles Phentermine (Compound) and Phentermine may lead to a major life threatening interaction when taken with Dexfenfluramine
Tranylcypromine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine may lead to a major life threatening interaction when taken with Dexfenfluramine
Tranylcypromine (Compound) resembles Amphetamine (Compound) and Amphetamine may lead to a major life threatening interaction when taken with Dexfenfluramine
Tranylcypromine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tolterodine (Compound) and Tolterodine may cause a minor interaction that can limit clinical effects when taken with Dexfenfluramine
Tranylcypromine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metamfetamine (Compound) and Metamfetamine may lead to a major life threatening interaction when taken with Dexfenfluramine
Tranylcypromine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Tranylcypromine (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Dapagliflozin (Compound) and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Tranylcypromine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cinacalcet (Compound) and Cinacalcet (Compound) resembles Dexfenfluramine (Compound)
Tranylcypromine (Compound) resembles Phentermine (Compound) and Phentermine (Compound) resembles Metamfetamine (Compound) and Phentermine may lead to a major life threatening interaction when taken with Metamfetamine and Metamfetamine may lead to a major life threatening interaction when taken with Dexfenfluramine