DDInter1309 DDInter1729
A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
Nizatidine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Nizatidine {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sulindac
Nizatidine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) is bound by {v} (Compound) Sulindac
Nizatidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Triamterene
Triamterene {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sulindac
Nizatidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Triamterene
Triamterene {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Nizatidine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Sulindac
Nizatidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Erlotinib
Erlotinib {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sulindac
Nizatidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Duloxetine
Duloxetine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Sulindac
Nizatidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Erlotinib
Erlotinib {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Sulindac
Nizatidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sulindac
Nizatidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Nizatidine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sulindac (Compound)
Nizatidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is regulated by AKR1B1 (Gene) and AKR1B1 (Gene) is bound by Sulindac (Compound)
Nizatidine may cause a minor interaction that can limit clinical effects when taken with Triamterene and Triamterene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sulindac (Compound)
Nizatidine may cause a minor interaction that can limit clinical effects when taken with Triamterene and Triamterene (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Nizatidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is associated with osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Sulindac (Compound)
Nizatidine may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sulindac (Compound)
Nizatidine may cause a minor interaction that can limit clinical effects when taken with Duloxetine and Duloxetine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Sulindac (Compound)
Nizatidine may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Sulindac (Compound)
Nizatidine may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sulindac (Compound)