DDInter893 DDInter1181
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely. It was developed during World War II as a derivative of [quinacrine] with less severe side effects. Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2. **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.** Hydroxychloroquine was granted FDA approval on 18 April 1955.
Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Glutethimide
Glutethimide {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Methsuximide
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Methsuximide
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Methsuximide (Compound)
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Phenytoin (Compound) and Phenytoin (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Meperidine (Compound) and Meperidine (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Meperidine (Compound) and Meperidine (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Glutethimide (Compound) and Glutethimide (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Clobazam (Compound) and Clobazam (Compound) resembles Methsuximide (Compound)
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Methsuximide (Compound)