DDInter1717 DDInter48
Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances [A177655, F4519]. Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076].
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals . Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout . It was initially approved by the FDA in 1966 and is now formulated by several manufacturers .
Sucralfate {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sotalol
Sotalol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Allopurinol
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Theophylline {u} (Compound) binds {v} (Gene) SLC22A7
SLC22A7 {u} (Gene) is bound by {v} (Compound) Allopurinol
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Theophylline {u} (Compound) causes {v} (Side Effect) Status epilepticus
Status epilepticus {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Sucralfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Acarbose {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Hepatic function abnormal {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Sucralfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Glipizide {u} (Compound) causes {v} (Side Effect) Chills
Chills {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Sucralfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxytetracycline
Oxytetracycline {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Allopurinol
Sucralfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxycycline
Doxycycline {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Allopurinol
Sucralfate {u} may lead to a major life threatening interaction when taken with {v} Dolutegravir
Dolutegravir {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Allopurinol
Sucralfate (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Allopurinol (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Sotalol and Sotalol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Allopurinol (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Diclofenac and Diclofenac (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Allopurinol (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline (Compound) binds SLC22A7 (Gene) and SLC22A7 (Gene) is bound by Allopurinol (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Theophylline and Theophylline (Compound) causes Status epilepticus (Side Effect) and Status epilepticus (Side Effect) is caused by Allopurinol (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Allopurinol (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Allopurinol (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Oxytetracycline and Oxytetracycline (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Allopurinol (Compound)
Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Allopurinol (Compound)
Sucralfate may lead to a major life threatening interaction when taken with Dolutegravir and Dolutegravir (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Allopurinol (Compound)