DDInter1158 DDInter434
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Mesalazine {u} (Compound) causes {v} (Side Effect) Protein urine present
Protein urine present {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Mesalazine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Mesalazine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Mesalazine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Colistimethate
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Polymyxin B {u} (Compound) resembles {v} (Compound) Colistimethate
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} (Compound) causes {v} (Side Effect) Protein urine present
Protein urine present {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Mesalazine {u} (Compound) resembles {v} (Compound) Methyldopa
Methyldopa {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Colistimethate
Mesalazine (Compound) causes Protein urine present (Side Effect) and Protein urine present (Side Effect) is caused by Colistimethate (Compound)
Mesalazine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Polymyxin B (Compound) and Polymyxin B (Compound) resembles Colistimethate (Compound)
Mesalazine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Mesalazine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Bacitracin (Compound) and Bacitracin (Compound) resembles Colistimethate (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Colistimethate (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B and Polymyxin B (Compound) resembles Colistimethate (Compound)
Mesalazine (Compound) resembles Diflunisal (Compound) and Diflunisal (Compound) causes Protein urine present (Side Effect) and Protein urine present (Side Effect) is caused by Colistimethate (Compound)
Mesalazine (Compound) resembles Methyldopa (Compound) and Methyldopa (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Colistimethate (Compound)