DDInter1397 DDInter1903
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Paroxetine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Desvenlafaxine
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Desvenlafaxine
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Desmopressin
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine {u} (Compound) downregulates {v} (Gene) PRR7
PRR7 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urea
Paroxetine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Desvenlafaxine (Compound) and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Desvenlafaxine (Compound) and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Desmopressin (Compound) and Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Urea
Paroxetine (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Urea