DDInter1642 DDInter1789
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Thalidomide {u} (Compound) resembles {v} (Compound) Lenalidomide
Thalidomide {u} (Compound) treats {v} (Disease) hematologic cancer
Thalidomide {u} (Compound) binds {v} (Gene) FGFR2
Thalidomide {u} (Compound) upregulates {v} (Gene) TGFBR2
Thalidomide {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Immunologically Active Molecule Activity
Thalidomide {u} (Compound) downregulates {v} (Gene) ARNT2
Thalidomide {u} (Compound) causes {v} (Side Effect) Myocardial ischaemia
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Astemizole
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Rotavirus vaccine
Thalidomide (Compound) resembles Lenalidomide (Compound)
Thalidomide (Compound) treats hematologic cancer (Disease)
Thalidomide (Compound) binds FGFR2 (Gene)
Thalidomide (Compound) upregulates TGFBR2 (Gene)
Thalidomide (Compound) is included by Decreased Immunologically Active Molecule Activity (Pharmacologic Class)
Thalidomide (Compound) downregulates ARNT2 (Gene)
Thalidomide (Compound) causes Myocardial ischaemia (Side Effect)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Astemizole
Thalidomide may lead to a major life threatening interaction when taken with Rotavirus vaccine