DDInter162 DDInter459
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Baclofen {u} (Compound) causes {v} (Side Effect) Loss of consciousness
Loss of consciousness {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Baclofen {u} (Compound) causes {v} (Side Effect) Loss of consciousness
Loss of consciousness {u} (Side Effect) is caused by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Cyproheptadine
Baclofen {u} (Compound) causes {v} (Side Effect) Chest discomfort
Chest discomfort {u} (Side Effect) is caused by {v} (Compound) Milnacipran
Milnacipran {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Baclofen {u} (Compound) causes {v} (Side Effect) Chest tightness
Chest tightness {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Baclofen {u} (Compound) causes {v} (Side Effect) Loss of consciousness
Loss of consciousness {u} (Side Effect) is caused by {v} (Compound) Ketotifen
Ketotifen {u} (Compound) resembles {v} (Compound) Cyproheptadine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) binds {v} (Gene) UGT1A3
UGT1A3 {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Baclofen (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Cyproheptadine (Compound)
Baclofen (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Cyproheptadine (Compound)
Baclofen (Compound) causes Chest discomfort (Side Effect) and Chest discomfort (Side Effect) is caused by Milnacipran (Compound) and Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Baclofen (Compound) causes Chest tightness (Side Effect) and Chest tightness (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Baclofen (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Ketotifen (Compound) and Ketotifen (Compound) resembles Cyproheptadine (Compound)
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Cyproheptadine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) binds UGT1A3 (Gene) and UGT1A3 (Gene) is bound by Cyproheptadine (Compound)
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Cyproheptadine (Compound)