DDInter1841 DDInter381
Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and norepinpehrine which activate descending pain inhibitory pathways. Tramadol's effects on serotonin and norepinephrine mimic the effects of other SNRI antidepressants such as [dul
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Dexfenfluramine {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cinacalcet
Tramadol {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Cinacalcet
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Dexfenfluramine {u} may lead to a major life threatening interaction when taken with {v} Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} (Compound) causes {v} (Side Effect) Upper respiratory tract infection
Upper respiratory tract infection {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Terbinafine {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Terbinafine {u} (Compound) resembles {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Cinacalcet
Tramadol may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine (Compound) resembles Cinacalcet (Compound)
Tramadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cinacalcet (Compound)
Tramadol (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Cinacalcet (Compound)
Tramadol may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine (Compound) resembles Cinacalcet (Compound)
Tramadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Tramadol (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Tramadol (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine and Terbinafine (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Tramadol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine and Terbinafine (Compound) resembles Naftifine (Compound) and Naftifine (Compound) resembles Cinacalcet (Compound)