DDInter1476 DDInter125
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3†,5†-adenosine monophosphate (c-
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Pirbuterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Pirbuterol {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Pirbuterol {u} (Compound) resembles {v} (Compound) Bupranolol
Bupranolol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) interacts with {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) resembles {v} (Compound) Terbutaline
Terbutaline {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) interacts with {v} (Gene) DRD4
DRD4 {u} (Gene) is bound by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) resembles {v} (Compound) Terbutaline
Terbutaline {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Asenapine
Pirbuterol {u} (Compound) resembles {v} (Compound) Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Pirbuterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Asenapine (Compound)
Pirbuterol (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)
Pirbuterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Pirbuterol (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Pirbuterol (Compound) resembles Bupranolol (Compound) and Bupranolol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Asenapine (Compound)
Pirbuterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) interacts with ADRA2A (Gene) and ADRA2A (Gene) is bound by Asenapine (Compound)
Pirbuterol (Compound) resembles Terbutaline (Compound) and Terbutaline (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Asenapine (Compound)
Pirbuterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) interacts with DRD4 (Gene) and DRD4 (Gene) is bound by Asenapine (Compound)
Pirbuterol (Compound) resembles Terbutaline (Compound) and Terbutaline (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Asenapine (Compound)
Pirbuterol (Compound) resembles Salbutamol (Compound) and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Asenapine (Compound)