DDInter1300 DDInter336
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Nitisinone {u} (Compound) causes {v} (Side Effect) Nervousness
Nervousness {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) treats {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nilutamide {u} (Compound) treats {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) binds {v} (Gene) HPD
HPD {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nilutamide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Nitisinone {u} (Compound) resembles {v} (Compound) Nilutamide
Nilutamide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Nitisinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Modafinil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Celecoxib
Nitisinone (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Celecoxib (Compound)
Nitisinone (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) treats prostate cancer (Disease) and prostate cancer (Disease) is palliated by Celecoxib (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound) and Nilutamide (Compound) treats prostate cancer (Disease) and prostate cancer (Disease) is palliated by Celecoxib (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Celecoxib (Compound)
Nitisinone (Compound) binds HPD (Gene) and HPD (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Celecoxib (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound) and Nilutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Celecoxib (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Nitisinone (Compound) resembles Nilutamide (Compound) and Nilutamide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Celecoxib (Compound)