DDInter535 DDInter1065
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Licorice allergenic extract is used in allergenic testing.
Diazoxide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epoprostenol
Epoprostenol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Deflazacort
Deflazacort {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) palliates {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Phentolamine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Phentolamine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) palliates {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Minoxidil
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) downregulates {v} (Gene) ACOT9
ACOT9 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide {u} (Compound) binds {v} (Gene) GLUL
GLUL {u} (Gene) is upregulated by {v} (Compound) Budesonide
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Licorice
Diazoxide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) palliates hypertension (Disease) and hypertension (Disease) is palliated by Phentolamine (Compound) and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Phentolamine (Compound) and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) palliates hypertension (Disease) and hypertension (Disease) is treated by Minoxidil (Compound) and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) downregulates ACOT9 (Gene) and ACOT9 (Gene) is upregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Diazoxide (Compound) binds GLUL (Gene) and GLUL (Gene) is upregulated by Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Licorice