DDInter596 DDInter1778
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is upregulated by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) upregulates {v} (Gene) TCTN1
TCTN1 {u} (Gene) is downregulated by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetrabenazine
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Donepezil {u} (Compound) resembles {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) binds {v} (Gene) CBR1
CBR1 {u} (Gene) regulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is regulated by {v} (Gene) WDR61
WDR61 {u} (Gene) is upregulated by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) upregulates {v} (Gene) TCTN1
TCTN1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is upregulated by {v} (Compound) Tetrabenazine
Doxorubicin {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} (Compound) resembles {v} (Compound) Tetrabenazine
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tetrabenazine (Compound)
Doxorubicin (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is upregulated by Tetrabenazine (Compound)
Doxorubicin (Compound) upregulates TCTN1 (Gene) and TCTN1 (Gene) is downregulated by Tetrabenazine (Compound)
Doxorubicin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Tetrabenazine (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound) and Donepezil (Compound) resembles Tetrabenazine (Compound)
Doxorubicin (Compound) binds CBR1 (Gene) and CBR1 (Gene) regulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Tetrabenazine (Compound)
Doxorubicin (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is regulated by WDR61 (Gene) and WDR61 (Gene) is upregulated by Tetrabenazine (Compound)
Doxorubicin (Compound) upregulates TCTN1 (Gene) and TCTN1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is upregulated by Tetrabenazine (Compound)
Doxorubicin (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Donepezil (Compound) and Donepezil (Compound) resembles Tetrabenazine (Compound)