DDInter298 DDInter150
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Carboplatin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) treats {v} (Disease) uterine cancer
uterine cancer {u} (Disease) is associated with {v} (Gene) SUZ12
SUZ12 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is associated with {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) binds {v} (Gene) GSTT1
GSTT1 {u} (Gene) is downregulated by {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) binds {v} (Gene) SLC31A1
SLC31A1 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Carboplatin {u} (Compound) binds {v} (Gene) SOD1
SOD1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Carboplatin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Azathioprine (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Carboplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Carboplatin (Compound) treats uterine cancer (Disease) and uterine cancer (Disease) is associated with SUZ12 (Gene) and SUZ12 (Gene) is downregulated by Azathioprine (Compound)
Carboplatin (Compound) binds MPO (Gene) and MPO (Gene) is associated with rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Carboplatin (Compound) binds GSTT1 (Gene) and GSTT1 (Gene) is downregulated by rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)
Carboplatin (Compound) binds SLC31A1 (Gene) and SLC31A1 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Carboplatin (Compound) binds SOD1 (Gene) and SOD1 (Gene) interacts with STUB1 (Gene) and SOD1 (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)