DDInter130 DDInter1676
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Atenolol {u} (Compound) resembles {v} (Compound) Oxprenolol
Atenolol {u} (Compound) resembles {v} (Compound) Chlorphenesin
Atenolol {u} (Compound) binds {v} (Gene) ADRB2
Atenolol {u} (Compound) upregulates {v} (Gene) UBQLN2
Atenolol {u} (Compound) causes {v} (Side Effect) Dry mouth
Atenolol (Compound) resembles Oxprenolol (Compound)
Atenolol (Compound) resembles Chlorphenesin (Compound)
Atenolol (Compound) binds ADRB2 (Gene)
Atenolol (Compound) upregulates UBQLN2 (Gene)
Atenolol (Compound) causes Dry mouth (Side Effect)