DDInter48 DDInter150
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout. It was initially approved by the FDA in 1966 and is now formulated by several manufacturers.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Allopurinol {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Allopurinol {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) resembles {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is associated with {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Allopurinol (Compound) binds XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)
Allopurinol (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Allopurinol (Compound) treats gout (Disease) and gout (Disease) resembles rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is associated with HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)