DDInter162 DDInter395
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Baclofen {u} (Compound) causes {v} (Side Effect) Chest tightness
Chest tightness {u} (Side Effect) is caused by {v} (Compound) Clemastine
Baclofen {u} (Compound) causes {v} (Side Effect) Chest tightness
Chest tightness {u} (Side Effect) is caused by {v} (Compound) Eletriptan
Eletriptan {u} (Compound) resembles {v} (Compound) Clemastine
Baclofen {u} (Compound) causes {v} (Side Effect) Nasal congestion
Nasal congestion {u} (Side Effect) is caused by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Clemastine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Clemastine
Baclofen {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Trospium
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorphenesin
Chlorphenesin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clemastine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Quazepam
Quazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Baclofen (Compound) causes Chest tightness (Side Effect) and Chest tightness (Side Effect) is caused by Clemastine (Compound)
Baclofen (Compound) causes Chest tightness (Side Effect) and Chest tightness (Side Effect) is caused by Eletriptan (Compound) and Eletriptan (Compound) resembles Clemastine (Compound)
Baclofen (Compound) causes Nasal congestion (Side Effect) and Nasal congestion (Side Effect) is caused by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Clemastine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Clemastine (Compound)
Baclofen (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Trospium (Compound) and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Baclofen (Compound) resembles Chlorphenesin (Compound) and Chlorphenesin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clemastine (Compound)
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Quazepam (Compound) and Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Clemastine