DDInter458 DDInter1431
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Perindopril
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Perindopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Perindopril
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Perindopril
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Perindopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Gentamicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Perindopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abdominal pain upper
Abdominal pain upper {u} (Side Effect) is caused by {v} (Compound) Ramipril
Ramipril {u} (Compound) resembles {v} (Compound) Perindopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Skin infection
Skin infection {u} (Side Effect) is caused by {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perindopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Menstrual disorder
Menstrual disorder {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Perindopril
Cyclosporine {u} (Compound) causes {v} (Side Effect) Chills
Chills {u} (Side Effect) is caused by {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Perindopril
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Perindopril (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Perindopril (Compound)
Cyclosporine (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Perindopril (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cilazapril (Compound) and Cilazapril (Compound) resembles Perindopril (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Perindopril (Compound)
Cyclosporine (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Gentamicin (Compound) and Gentamicin may cause a minor interaction that can limit clinical effects when taken with Perindopril
Cyclosporine (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Ramipril (Compound) and Ramipril (Compound) resembles Perindopril (Compound)
Cyclosporine (Compound) causes Skin infection (Side Effect) and Skin infection (Side Effect) is caused by Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Perindopril
Cyclosporine (Compound) causes Menstrual disorder (Side Effect) and Menstrual disorder (Side Effect) is caused by Bupropion (Compound) and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Perindopril
Cyclosporine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Cilazapril (Compound) and Cilazapril (Compound) resembles Perindopril (Compound)