DDInter471 DDInter105
Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity that works by inhibiting activated factor X (Factor Xa) and activated factor II (Factor IIa). It is chemically distinct from heparin by containing different protein binding properties, thus has lower cross-reactivity in heparin-intolerant patients. Danaproid is used in the treatment of heparin-induced thrombocytopenia (HIT) as an off-label indication and prevention of post-operative deep venous thrombosis (DVT). While it was initially approved by the FDA as Orgaran™, danaparoid was withdrawn by Organon International on August
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Danaparoid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chamomile
Danaparoid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiloride
Danaparoid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Protein C
Danaparoid {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Danaparoid {u} may lead to a major life threatening interaction when taken with {v} Ibritumomab tiuxetan
Danaparoid may cause a minor interaction that can limit clinical effects when taken with Chamomile
Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Amiloride
Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Protein C
Danaparoid may lead to a major life threatening interaction when taken with Desirudin
Danaparoid may lead to a major life threatening interaction when taken with Ibritumomab tiuxetan