DDInter1179 DDInter1763
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) In the US, methoxyflurane is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Methoxyflurane {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Methoxyflurane {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) ATP2C1
ATP2C1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) covaries with {v} (Gene) YRDC
YRDC {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) GABRB3
GABRB3 {u} (Gene) interacts with {v} (Gene) PPP2CA
PPP2CA {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) ATP5D
ATP5D {u} (Gene) regulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Methoxyflurane {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Methoxyflurane {u} (Compound) binds {v} (Gene) GRIA1
GRIA1 {u} (Gene) covaries with {v} (Gene) EXOSC4
EXOSC4 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Methoxyflurane may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Methoxyflurane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Methoxyflurane may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Methoxyflurane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Methoxyflurane (Compound) binds ATP2C1 (Gene) and ATP2C1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Temsirolimus (Compound)
Methoxyflurane (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) covaries with YRDC (Gene) and YRDC (Gene) is downregulated by Temsirolimus (Compound)
Methoxyflurane (Compound) binds GABRB3 (Gene) and GABRB3 (Gene) interacts with PPP2CA (Gene) and PPP2CA (Gene) is downregulated by Temsirolimus (Compound)
Methoxyflurane (Compound) binds ATP5D (Gene) and ATP5D (Gene) regulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Temsirolimus (Compound)
Methoxyflurane may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Methoxyflurane (Compound) binds GRIA1 (Gene) and GRIA1 (Gene) covaries with EXOSC4 (Gene) and EXOSC4 (Gene) is downregulated by Temsirolimus (Compound)