DDInter392 DDInter1938
An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Cladribine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Vincristine
Cladribine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Vincristine
Cladribine {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Cladribine {u} (Compound) upregulates {v} (Gene) ATF3
ATF3 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Cladribine {u} (Compound) upregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Cladribine {u} (Compound) downregulates {v} (Gene) POLG2
POLG2 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Cladribine {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Vincristine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Voacamine
Voacamine {u} (Compound) resembles {v} (Compound) Vincristine
Cladribine may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Cladribine may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine (Compound) resembles Vincristine (Compound)
Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Vincristine (Compound)
Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Vincristine (Compound)
Cladribine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is upregulated by Vincristine (Compound)
Cladribine (Compound) upregulates ATF3 (Gene) and ATF3 (Gene) is upregulated by Vincristine (Compound)
Cladribine (Compound) upregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Vincristine (Compound)
Cladribine (Compound) downregulates POLG2 (Gene) and POLG2 (Gene) is downregulated by Vincristine (Compound)
Cladribine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Vincristine (Compound)
Cladribine may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine (Compound) resembles Voacamine (Compound) and Voacamine (Compound) resembles Vincristine (Compound)