DDInter336 DDInter813
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
Celecoxib {u} (Compound) causes {v} (Side Effect) Tendon rupture
Tendon rupture {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Tendon rupture
Tendon rupture {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Blood sodium increased
Blood sodium increased {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Transient ischaemic attack
Transient ischaemic attack {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Creatine phosphokinase increased
Creatine phosphokinase increased {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Haemoglobin increased
Haemoglobin increased {u} (Side Effect) is caused by {v} (Compound) Vandetanib
Vandetanib {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Vemurafenib
Vemurafenib {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Celecoxib {u} (Compound) binds {v} (Gene) CA14
CA14 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Celecoxib (Compound) causes Tendon rupture (Side Effect) and Tendon rupture (Side Effect) is caused by Gemifloxacin (Compound)
Celecoxib (Compound) causes Tendon rupture (Side Effect) and Tendon rupture (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gemifloxacin (Compound)
Celecoxib (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Celecoxib (Compound) causes Blood sodium increased (Side Effect) and Blood sodium increased (Side Effect) is caused by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Celecoxib (Compound) causes Transient ischaemic attack (Side Effect) and Transient ischaemic attack (Side Effect) is caused by Capecitabine (Compound) and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Celecoxib (Compound) causes Creatine phosphokinase increased (Side Effect) and Creatine phosphokinase increased (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Celecoxib (Compound) causes Haemoglobin increased (Side Effect) and Haemoglobin increased (Side Effect) is caused by Vandetanib (Compound) and Vandetanib may lead to a major life threatening interaction when taken with Gemifloxacin
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) resembles Vemurafenib (Compound) and Vemurafenib may lead to a major life threatening interaction when taken with Gemifloxacin
Celecoxib (Compound) binds CA14 (Gene) and CA14 (Gene) is bound by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Gemifloxacin
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Gemifloxacin (Compound)