DDInter1853 DDInter809
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Tretinoin {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) CTSL
CTSL {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) BID
BID {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is regulated by {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) CTSL
CTSL {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Gatifloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Tretinoin (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is upregulated by Gatifloxacin (Compound)
Tretinoin (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Gatifloxacin (Compound)
Tretinoin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Gatifloxacin (Compound)
Tretinoin (Compound) upregulates CTSL (Gene) and CTSL (Gene) is downregulated by Gatifloxacin (Compound)
Tretinoin (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Gatifloxacin (Compound)
Tretinoin (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by BID (Gene) and BID (Gene) is upregulated by Gatifloxacin (Compound)
Tretinoin (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is regulated by PAK1 (Gene) and PAK1 (Gene) is upregulated by Gatifloxacin (Compound)
Tretinoin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Gatifloxacin (Compound)
Tretinoin (Compound) upregulates CTSL (Gene) and CTSL (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Gatifloxacin (Compound)
Tretinoin (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)