DDInter998 DDInter393
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Ivermectin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) downregulates {v} (Gene) TCERG1
TCERG1 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Troleandomycin
Troleandomycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is regulated by {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) downregulates {v} (Gene) TCERG1
TCERG1 {u} (Gene) regulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) downregulates {v} (Gene) DNTTIP2
DNTTIP2 {u} (Gene) regulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Ivermectin {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Dirithromycin
Dirithromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Ivermectin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Ivermectin (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Clarithromycin (Compound)
Ivermectin (Compound) downregulates TCERG1 (Gene) and TCERG1 (Gene) is downregulated by Clarithromycin (Compound)
Ivermectin (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Ivermectin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Troleandomycin (Compound) and Troleandomycin (Compound) resembles Clarithromycin (Compound)
Ivermectin (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is regulated by CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compound)
Ivermectin (Compound) downregulates TCERG1 (Gene) and TCERG1 (Gene) regulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Clarithromycin (Compound)
Ivermectin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Ivermectin (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) regulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Clarithromycin (Compound)
Ivermectin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dirithromycin (Compound) and Dirithromycin (Compound) resembles Clarithromycin (Compound)