DDInter458 DDInter779
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Foscarnet
Cyclosporine {u} (Compound) causes {v} (Side Effect) Blood urea increased
Blood urea increased {u} (Side Effect) is caused by {v} (Compound) Foscarnet
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Foscarnet
Cyclosporine {u} (Compound) causes {v} (Side Effect) Blood urea increased
Blood urea increased {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Foscarnet
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Foscarnet
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Palonosetron
Palonosetron {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Foscarnet
Cyclosporine {u} (Compound) causes {v} (Side Effect) Muscle contractions involuntary
Muscle contractions involuntary {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Foscarnet
Cyclosporine {u} (Compound) downregulates {v} (Gene) MBOAT7
MBOAT7 {u} (Gene) covaries with {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Foscarnet
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) covaries with {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Foscarnet
Cyclosporine {u} (Compound) downregulates {v} (Gene) MBOAT7
MBOAT7 {u} (Gene) is downregulated by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Foscarnet
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Foscarnet (Compound)
Cyclosporine (Compound) causes Blood urea increased (Side Effect) and Blood urea increased (Side Effect) is caused by Foscarnet (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Foscarnet
Cyclosporine (Compound) causes Blood urea increased (Side Effect) and Blood urea increased (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet
Cyclosporine (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Foscarnet
Cyclosporine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Palonosetron (Compound) and Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet
Cyclosporine (Compound) causes Muscle contractions involuntary (Side Effect) and Muscle contractions involuntary (Side Effect) is caused by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Foscarnet
Cyclosporine (Compound) downregulates MBOAT7 (Gene) and MBOAT7 (Gene) covaries with SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Foscarnet (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) covaries with SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Foscarnet (Compound)
Cyclosporine (Compound) downregulates MBOAT7 (Gene) and MBOAT7 (Gene) is downregulated by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet