DDInter1174 DDInter1396
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Paromomycin
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Neomycin {u} (Compound) resembles {v} (Compound) Paromomycin
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Acarbose {u} (Compound) resembles {v} (Compound) Paromomycin
Methotrexate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Paromomycin
Methotrexate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Paromomycin
Methotrexate {u} (Compound) upregulates {v} (Gene) NPDC1
NPDC1 {u} (Gene) is downregulated by {v} (Compound) Paromomycin
Methotrexate {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Paromomycin
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Tobramycin
Tobramycin {u} (Compound) resembles {v} (Compound) Paromomycin
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Acarbose {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Paromomycin
Methotrexate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Paromomycin
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin (Compound) resembles Paromomycin (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin (Compound) resembles Paromomycin (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Paromomycin (Compound)
Methotrexate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Paromomycin (Compound)
Methotrexate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Paromomycin (Compound)
Methotrexate (Compound) upregulates NPDC1 (Gene) and NPDC1 (Gene) is downregulated by Paromomycin (Compound)
Methotrexate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Paromomycin (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin (Compound) resembles Tobramycin (Compound) and Tobramycin (Compound) resembles Paromomycin (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Paromomycin (Compound)
Methotrexate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Paromomycin (Compound)