DDInter781 DDInter537
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin]. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).
Fosinopril {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Fosinopril {u} (Compound) resembles {v} (Compound) Trandolapril
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Fosinopril {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Clonidine
Clonidine {u} (Compound) resembles {v} (Compound) Diclofenac
Fosinopril {u} (Compound) causes {v} (Side Effect) Injury
Injury {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Fosinopril {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Lorazepam
Lorazepam {u} (Compound) resembles {v} (Compound) Diclofenac
Fosinopril {u} (Compound) causes {v} (Side Effect) Breath odour
Breath odour {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Fosinopril {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Nizatidine
Nizatidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Fosinopril {u} (Compound) causes {v} (Side Effect) Laryngitis
Laryngitis {u} (Side Effect) is caused by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Diclofenac
Fosinopril (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Diclofenac (Compound)
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Fosinopril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Fosinopril (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Clonidine (Compound) and Clonidine (Compound) resembles Diclofenac (Compound)
Fosinopril (Compound) causes Injury (Side Effect) and Injury (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Diclofenac
Fosinopril (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Lorazepam (Compound) and Lorazepam (Compound) resembles Diclofenac (Compound)
Fosinopril (Compound) causes Breath odour (Side Effect) and Breath odour (Side Effect) is caused by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Fosinopril (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Nizatidine (Compound) and Nizatidine may cause a minor interaction that can limit clinical effects when taken with Diclofenac
Fosinopril (Compound) causes Laryngitis (Side Effect) and Laryngitis (Side Effect) is caused by Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Diclofenac (Compound)