DDInter1716 DDInter150
Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Succinylcholine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Succinylcholine {u} (Compound) resembles {v} (Compound) Carbachol
Carbachol {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Succinylcholine {u} (Compound) binds {v} (Gene) BCHE
BCHE {u} (Gene) is associated with {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is treated by {v} (Compound) Azathioprine
Succinylcholine {u} (Compound) resembles {v} (Compound) Carbachol
Carbachol {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Succinylcholine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Irinotecan
Irinotecan {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Succinylcholine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ranitidine
Ranitidine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Succinylcholine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Physostigmine
Physostigmine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Succinylcholine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ranitidine
Ranitidine {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Succinylcholine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Metoclopramide {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Azathioprine
Succinylcholine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Thalidomide {u} (Compound) upregulates {v} (Gene) INTS3
INTS3 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Succinylcholine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Azathioprine (Compound)
Succinylcholine (Compound) resembles Carbachol (Compound) and Carbachol (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Azathioprine (Compound)
Succinylcholine (Compound) binds BCHE (Gene) and BCHE (Gene) is associated with multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Azathioprine (Compound)
Succinylcholine (Compound) resembles Carbachol (Compound) and Carbachol (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Azathioprine (Compound)
Succinylcholine may cause a minor interaction that can limit clinical effects when taken with Irinotecan and Irinotecan (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Azathioprine (Compound)
Succinylcholine may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Azathioprine (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and Physostigmine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Azathioprine (Compound)
Succinylcholine may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Azathioprine (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Azathioprine (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide (Compound) upregulates INTS3 (Gene) and INTS3 (Gene) is downregulated by Azathioprine (Compound)