DDInter458 DDInter456
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Haemolytic uraemic syndrome
Haemolytic uraemic syndrome {u} (Side Effect) is caused by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cyclophosphamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is downregulated by {v} (Compound) Cyclophosphamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Haemolytic uraemic syndrome
Haemolytic uraemic syndrome {u} (Side Effect) is caused by {v} (Compound) Mitomycin
Mitomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclophosphamide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cyclophosphamide (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Cyclophosphamide (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Cyclophosphamide (Compound)
Cyclosporine (Compound) causes Haemolytic uraemic syndrome (Side Effect) and Haemolytic uraemic syndrome (Side Effect) is caused by Cyclophosphamide (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Cyclophosphamide
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Cyclophosphamide (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cyclophosphamide (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Cyclophosphamide (Compound)
Cyclosporine (Compound) causes Haemolytic uraemic syndrome (Side Effect) and Haemolytic uraemic syndrome (Side Effect) is caused by Mitomycin (Compound) and Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide