DDInter1397 DDInter573
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dipyridamole
Paroxetine {u} (Compound) causes {v} (Side Effect) Ventricular extrasystoles
Ventricular extrasystoles {u} (Side Effect) is caused by {v} (Compound) Dipyridamole
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Paroxetine {u} (Compound) causes {v} (Side Effect) Ventricular extrasystoles
Ventricular extrasystoles {u} (Side Effect) is caused by {v} (Compound) Theophylline
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Paroxetine {u} (Compound) causes {v} (Side Effect) Distress
Distress {u} (Side Effect) is caused by {v} (Compound) Oxaprozin
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Paroxetine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) regulates {v} (Gene) PDE8A
PDE8A {u} (Gene) is bound by {v} (Compound) Dipyridamole
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dipyridamole
Paroxetine {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dipyridamole
Paroxetine {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) interacts with {v} (Gene) PDE6H
PDE6H {u} (Gene) is bound by {v} (Compound) Dipyridamole
Paroxetine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Dipyridamole
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dipyridamole (Compound)
Paroxetine (Compound) causes Ventricular extrasystoles (Side Effect) and Ventricular extrasystoles (Side Effect) is caused by Dipyridamole (Compound)
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Paroxetine (Compound) causes Ventricular extrasystoles (Side Effect) and Ventricular extrasystoles (Side Effect) is caused by Theophylline (Compound) and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Paroxetine (Compound) causes Distress (Side Effect) and Distress (Side Effect) is caused by Oxaprozin (Compound) and Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Paroxetine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) regulates PDE8A (Gene) and PDE8A (Gene) is bound by Dipyridamole (Compound)
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Paroxetine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Dipyridamole (Compound)
Paroxetine (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) interacts with PDE6H (Gene) and PDE6H (Gene) is bound by Dipyridamole (Compound)
Paroxetine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Dipyridamole (Compound)