DDInter1233 DDInter973
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
Mitotane {u} (Compound) downregulates {v} (Gene) PEG10
PEG10 {u} (Gene) is downregulated by {v} (Compound) Irinotecan
Mitotane {u} (Compound) causes {v} (Side Effect) Visual impairment
Visual impairment {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Mitotane {u} (Compound) downregulates {v} (Gene) PEG10
PEG10 {u} (Gene) is downregulated by {v} (Disease) pancreatic cancer
pancreatic cancer {u} (Disease) is treated by {v} (Compound) Irinotecan
Mitotane {u} (Compound) causes {v} (Side Effect) Visual impairment
Visual impairment {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Irinotecan
Mitotane {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Mitotane {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Irinotecan
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Mitotane {u} (Compound) downregulates {v} (Gene) PEG10
PEG10 {u} (Gene) is regulated by {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Mitotane {u} (Compound) resembles {v} (Compound) Delorazepam
Delorazepam {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Irinotecan
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Irinotecan
Mitotane (Compound) downregulates PEG10 (Gene) and PEG10 (Gene) is downregulated by Irinotecan (Compound)
Mitotane (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Irinotecan (Compound)
Mitotane (Compound) downregulates PEG10 (Gene) and PEG10 (Gene) is downregulated by pancreatic cancer (Disease) and pancreatic cancer (Disease) is treated by Irinotecan (Compound)
Mitotane (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a minor interaction that can limit clinical effects when taken with Irinotecan
Mitotane (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Mitotane (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Irinotecan
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Mitotane (Compound) downregulates PEG10 (Gene) and PEG10 (Gene) is regulated by RRP8 (Gene) and RRP8 (Gene) is upregulated by Irinotecan (Compound)
Mitotane (Compound) resembles Delorazepam (Compound) and Delorazepam (Compound) resembles Clozapine (Compound) and Clozapine may lead to a major life threatening interaction when taken with Irinotecan
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound)