DDInter1300 DDInter1627
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Nitisinone {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) binds {v} (Gene) SCN2A
SCN2A {u} (Gene) is bound by {v} (Compound) Rufinamide
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Primidone
Primidone {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Nitisinone {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Nitisinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Modafinil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Nitisinone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Rufinamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) binds SCN2A (Gene) and SCN2A (Gene) is bound by Rufinamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Nitisinone (Compound) resembles Flutamide (Compound) and Flutamide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)