DDInter1042 DDInter1470
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Pimozide {u} (Compound) resembles {v} (Compound) Fexofenadine
Pimozide {u} (Compound) resembles {v} (Compound) Ezetimibe
Pimozide {u} may lead to a major life threatening interaction when taken with {v} Astemizole
Pimozide {u} (Compound) binds {v} (Gene) CALM3
Pimozide {u} (Compound) upregulates {v} (Gene) GNPDA1
Pimozide {u} (Compound) palliates {v} (Disease) Gilles de la Tourette syndrome
Pimozide {u} (Compound) downregulates {v} (Gene) TMEM109
Pimozide {u} (Compound) causes {v} (Side Effect) Hypertension
Pimozide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Pimozide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Pimozide (Compound) resembles Fexofenadine (Compound)
Pimozide (Compound) resembles Ezetimibe (Compound)
Pimozide may lead to a major life threatening interaction when taken with Astemizole
Pimozide (Compound) binds CALM3 (Gene)
Pimozide (Compound) upregulates GNPDA1 (Gene)
Pimozide (Compound) palliates Gilles de la Tourette syndrome (Disease)
Pimozide (Compound) downregulates TMEM109 (Gene)
Pimozide (Compound) causes Hypertension (Side Effect)
Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine