DDInter1287 DDInter1376
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Nicardipine {u} (Compound) resembles {v} (Compound) Felodipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Nicardipine {u} (Compound) treats {v} (Disease) hypertension
Nicardipine {u} (Compound) binds {v} (Gene) PDE1A
Nicardipine {u} (Compound) upregulates {v} (Gene) NNT
Nicardipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Nicardipine {u} (Compound) downregulates {v} (Gene) CAST
Nicardipine {u} (Compound) causes {v} (Side Effect) Nervousness
Nicardipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Nicardipine (Compound) resembles Felodipine (Compound)
Nicardipine (Compound) resembles Clevidipine (Compound)
Nicardipine (Compound) treats hypertension (Disease)
Nicardipine (Compound) binds PDE1A (Gene)
Nicardipine (Compound) upregulates NNT (Gene)
Nicardipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Nicardipine (Compound) downregulates CAST (Gene)
Nicardipine (Compound) causes Nervousness (Side Effect)
Nicardipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid