DDInter336 DDInter360
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Celecoxib {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Chlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Nephritis interstitial
Nephritis interstitial {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Hydroflumethiazide
Hydroflumethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Nephritis interstitial
Nephritis interstitial {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Cyclothiazide
Cyclothiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Nephritis interstitial
Nephritis interstitial {u} (Side Effect) is caused by {v} (Compound) Lansoprazole
Lansoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Propantheline
Propantheline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Glycopyrronium
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Haematuria
Haematuria {u} (Side Effect) is caused by {v} (Compound) Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Celecoxib (Compound) binds CA2 (Gene) and CA2 (Gene) is bound by Chlorothiazide (Compound)
Celecoxib (Compound) causes Nephritis interstitial (Side Effect) and Nephritis interstitial (Side Effect) is caused by Chlorothiazide (Compound)
Celecoxib (Compound) binds CA2 (Gene) and CA2 (Gene) is bound by Hydroflumethiazide (Compound) and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Celecoxib (Compound) causes Nephritis interstitial (Side Effect) and Nephritis interstitial (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Chlorothiazide (Compound)
Celecoxib (Compound) binds CA2 (Gene) and CA2 (Gene) is bound by Cyclothiazide (Compound) and Cyclothiazide (Compound) resembles Chlorothiazide (Compound)
Celecoxib (Compound) causes Nephritis interstitial (Side Effect) and Nephritis interstitial (Side Effect) is caused by Lansoprazole (Compound) and Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide
Celecoxib (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Propantheline (Compound) and Propantheline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide
Celecoxib (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Glycopyrronium (Compound) and Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide
Celecoxib (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Salbutamol (Compound) and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound) and Diazoxide (Compound) resembles Chlorothiazide (Compound)