DDInter362 DDInter1747
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orphenadrine
Chlorpheniramine {u} (Compound) resembles {v} (Compound) Chloropyramine
Chlorpheniramine {u} (Compound) resembles {v} (Compound) Pheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Chlorpheniramine {u} (Compound) binds {v} (Gene) CYP2D6
Chlorpheniramine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Chlorpheniramine {u} (Compound) downregulates {v} (Gene) AKR1B10
Chlorpheniramine {u} (Compound) causes {v} (Side Effect) Drowsiness
Chlorpheniramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chlorpheniramine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine
Chlorpheniramine (Compound) resembles Chloropyramine (Compound)
Chlorpheniramine (Compound) resembles Pheniramine (Compound)
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Chlorpheniramine (Compound) binds CYP2D6 (Gene)
Chlorpheniramine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Chlorpheniramine (Compound) downregulates AKR1B10 (Gene)
Chlorpheniramine (Compound) causes Drowsiness (Side Effect)
Chlorpheniramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chlorpheniramine may lead to a major life threatening interaction when taken with Dextropropoxyphene