DDInter298 DDInter596
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Carboplatin {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Epirubicin
Epirubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is associated with {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) resembles {v} (Disease) stomach cancer
stomach cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) resembles {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Carboplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is upregulated by {v} (Disease) pancreatic cancer
pancreatic cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Carboplatin (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Doxorubicin (Compound)
Carboplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) is bound by Doxorubicin (Compound)
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Doxorubicin (Compound)
Carboplatin (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Epirubicin (Compound) and Epirubicin (Compound) resembles Doxorubicin (Compound)
Carboplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) is associated with prostate cancer (Disease) and prostate cancer (Disease) is treated by Doxorubicin (Compound)
Carboplatin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) resembles stomach cancer (Disease) and stomach cancer (Disease) is treated by Doxorubicin (Compound)
Carboplatin (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) resembles prostate cancer (Disease) and prostate cancer (Disease) is treated by Doxorubicin (Compound)
Carboplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) is upregulated by pancreatic cancer (Disease) and pancreatic cancer (Disease) is treated by Doxorubicin (Compound)