DDInter1420 DDInter704
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentamidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Pentamidine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is upregulated by {v} (Compound) Everolimus
Pentamidine {u} (Compound) upregulates {v} (Gene) PPARD
PPARD {u} (Gene) is upregulated by {v} (Compound) Everolimus
Pentamidine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Pentamidine {u} (Compound) upregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Pentamidine {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Everolimus
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentamidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentamidine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentamidine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound)
Pentamidine (Compound) downregulates PNP (Gene) and PNP (Gene) is upregulated by Everolimus (Compound)
Pentamidine (Compound) upregulates PPARD (Gene) and PPARD (Gene) is upregulated by Everolimus (Compound)
Pentamidine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Everolimus (Compound)
Pentamidine (Compound) upregulates JADE2 (Gene) and JADE2 (Gene) is downregulated by Everolimus (Compound)
Pentamidine (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Everolimus (Compound)
Pentamidine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Pentamidine (Compound) downregulates PNP (Gene) and PNP (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)