DDInter948 DDInter1185
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading to the inhibition of adrenergic neuronal outflow and reduction of vasoconstrictor adrenergic signals. Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. First introduced in 1960 as an antihypertensive agent, methyldopa was considered to be useful in certain patient populations, such as pregnant women and patients with renal insufficiency. Since then, methyldopa was largely replaced by newer, better-tolerated antihypertensive agents; however, it is still used as monotherapy or in combination with [hydrochlorothiazide]. Methyldopa is also available as intravenous injection, which is used to manage hypertension when oral therapy is unfeasible and to treat hypertensive crisis.
Methyldopa {u} (Compound) resembles {v} (Compound) Norepinephrine
Methyldopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epinephrine
Methyldopa {u} (Compound) resembles {v} (Compound) Droxidopa
Methyldopa {u} (Compound) treats {v} (Disease) hypertension
Methyldopa {u} (Compound) binds {v} (Gene) SLC15A1
Methyldopa {u} (Compound) upregulates {v} (Gene) NFATC3
Methyldopa {u} (Compound) downregulates {v} (Gene) ADI1
Methyldopa {u} (Compound) causes {v} (Side Effect) Rash
Methyldopa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Glipizide
Methyldopa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetohexamide
Methyldopa (Compound) resembles Norepinephrine (Compound)
Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Methyldopa (Compound) resembles Droxidopa (Compound)
Methyldopa (Compound) treats hypertension (Disease)
Methyldopa (Compound) binds SLC15A1 (Gene)
Methyldopa (Compound) upregulates NFATC3 (Gene)
Methyldopa (Compound) downregulates ADI1 (Gene)
Methyldopa (Compound) causes Rash (Side Effect)
Methyldopa may cause a minor interaction that can limit clinical effects when taken with Glipizide
Methyldopa may cause a minor interaction that can limit clinical effects when taken with Acetohexamide