DDInter1397 DDInter856
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Paroxetine {u} (Compound) binds {v} (Gene) CHRM5
Paroxetine {u} (Compound) upregulates {v} (Gene) CSTA
Paroxetine {u} (Compound) palliates {v} (Disease) panic disorder
Paroxetine {u} (Compound) downregulates {v} (Gene) GRWD1
Paroxetine {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Paroxetine (Compound) binds CHRM5 (Gene)
Paroxetine (Compound) upregulates CSTA (Gene)
Paroxetine (Compound) palliates panic disorder (Disease)
Paroxetine (Compound) downregulates GRWD1 (Gene)
Paroxetine (Compound) causes Anaphylactoid reaction (Side Effect)