DDInter1510 DDInter782
Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a child) makes it an integral to WHO's plan to eliminate schistosomiasis by 2030.[A263206,A263211] Despite being approved since 1980, the exact mechanism of action is yet to be elucidated.
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form of netupitant [FDA label]. Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting as major side effects. Considered one of the most distressing side effects of chemotherapy, nausea and vomiting has an immense impact on the quality of life of patients receiving certain antineoplastic therapies .
Praziquantel {u} (Compound) resembles {v} (Compound) Palonosetron
Praziquantel {u} (Compound) binds {v} (Gene) CYP3A5
Praziquantel {u} (Compound) upregulates {v} (Gene) PAK6
Praziquantel {u} (Compound) downregulates {v} (Gene) ATP6V1D
Praziquantel {u} (Compound) causes {v} (Side Effect) Decreased appetite
Praziquantel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Praziquantel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isavuconazonium
Praziquantel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Secobarbital
Praziquantel {u} may lead to a major life threatening interaction when taken with {v} Lumacaftor
Praziquantel {u} may lead to a major life threatening interaction when taken with {v} Rifabutin
Praziquantel (Compound) resembles Palonosetron (Compound)
Praziquantel (Compound) binds CYP3A5 (Gene)
Praziquantel (Compound) upregulates PAK6 (Gene)
Praziquantel (Compound) downregulates ATP6V1D (Gene)
Praziquantel (Compound) causes Decreased appetite (Side Effect)
Praziquantel may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital
Praziquantel may lead to a major life threatening interaction when taken with Lumacaftor
Praziquantel may lead to a major life threatening interaction when taken with Rifabutin