DDInter1042 DDInter120
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Arsenic trioxide {u} (Compound) binds {v} (Gene) JUN
Arsenic trioxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Arsenic trioxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium citrate
Arsenic trioxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Formoterol
Arsenic trioxide {u} may lead to a major life threatening interaction when taken with {v} Perphenazine
Arsenic trioxide {u} may lead to a major life threatening interaction when taken with {v} Histrelin
Arsenic trioxide (Compound) binds JUN (Gene)
Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Arsenic trioxide may lead to a major life threatening interaction when taken with Perphenazine
Arsenic trioxide may lead to a major life threatening interaction when taken with Histrelin