DDInter1852 DDInter721
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcut
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Fenoprofen
Treprostinil {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenbufen
Fenbufen {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Fenbufen
Fenbufen {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Fenoprofen
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Fenoprofen (Compound)
Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Fenoprofen (Compound)
Treprostinil (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Fenoprofen (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Fenoprofen (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Fenbufen (Compound) and Fenbufen (Compound) resembles Fenoprofen (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Fenoprofen (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Labetalol and Labetalol (Compound) resembles Fenoprofen (Compound)
Treprostinil (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Fenbufen (Compound) and Fenbufen (Compound) resembles Fenoprofen (Compound)
Treprostinil (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Labetalol (Compound) and Labetalol (Compound) resembles Fenoprofen (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Fenoprofen (Compound)