DDInter1641 DDInter278
Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007. After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe facial acne vulgaris [A39993, A39994] the US Food and Drug Administration approved Barcelona based Almirall, S.A.'s Seysara (sarecylcine) as a new first in class narrow spectrum tetracycline derived oral antibiotic for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients nine years of age and older. Seysara (sarecycline) was originally part of Allergan's US Medical Dermatology portfolio, before Almirall acquired the portfolio in the second half of 2018 as a means of consolidating and reinforcing the dermatology-focused
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Sarecycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Sarecycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terfenadine
Sarecycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium gluconate
Sarecycline {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Sarecycline may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Terfenadine
Sarecycline may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Sarecycline may lead to a major life threatening interaction when taken with Aminolevulinic acid