DDInter1441 DDInter1747
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. It is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold. Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Phenindamine {u} (Compound) resembles {v} (Compound) Mirtazapine
Phenindamine {u} (Compound) resembles {v} (Compound) Metixene
Phenindamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benzatropine
Phenindamine {u} (Compound) binds {v} (Gene) HRH1
Phenindamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Phenindamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opicapone
Phenindamine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Phenindamine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Phenindamine (Compound) resembles Mirtazapine (Compound)
Phenindamine (Compound) resembles Metixene (Compound)
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Benzatropine
Phenindamine (Compound) binds HRH1 (Gene)
Phenindamine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Phenindamine may lead to a major life threatening interaction when taken with Zonisamide
Phenindamine (Compound) resembles Amitriptyline (Compound) and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline