DDInter298 DDInter255
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Carboplatin {u} (Compound) causes {v} (Side Effect) Fluid overload
Fluid overload {u} (Side Effect) is caused by {v} (Compound) Busulfan
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) TP53BP2
TP53BP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is associated with {v} (Gene) ERBB2
ERBB2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) regulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Carboplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) downregulates {v} (Gene) STXBP1
STXBP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Carboplatin {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Carboplatin (Compound) causes Fluid overload (Side Effect) and Fluid overload (Side Effect) is caused by Busulfan (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Busulfan (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates TP53BP2 (Gene) and TP53BP2 (Gene) is upregulated by Busulfan (Compound)
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is associated with ERBB2 (Gene) and ERBB2 (Gene) is downregulated by Busulfan (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) regulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Busulfan (Compound)
Carboplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) downregulates STXBP1 (Gene) and STXBP1 (Gene) is downregulated by Busulfan (Compound)
Carboplatin (Compound) binds MPO (Gene) and MPO (Gene) is downregulated by hematologic cancer (Disease) and MPO (Disease) associated with hematologic cancer (Gene) and hematologic cancer (Disease) is treated by Busulfan (Compound)