DDInter717 DDInter1662
Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712, A214715] Fenfluramine is a serotonergic phenethylamine originally used as an appetite suppressant until concerns regarding cardiotoxicity in obese patients lead to its withdrawal from the market in 1997.[A214694, A214718, A11906] Through its ability to modulate neurotransmission, fenfluramine has reemerged as an effective therapy against pharmacoresistant seizures, such as those involved in Dravet syndrome.[A214688, A214691, A214700] Fenfluramine was granted initial FDA approval in 1973 prior to its withdrawal
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Fenfluramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Tolterodine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Sertraline
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Fenfluramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eliglustat
Eliglustat {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Fenfluramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Nateglinide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sertraline
Fenfluramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxone
Naloxone {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Sertraline
Fenfluramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolmetin
Tolmetin {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Fenfluramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Donepezil {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) upregulates {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Fenfluramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Argatroban
Argatroban {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Fenfluramine may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Sertraline (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sertraline (Compound)
Fenfluramine may cause a minor interaction that can limit clinical effects when taken with Naloxone and Naloxone (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Sertraline (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)
Fenfluramine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Sertraline (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Sertraline (Compound)
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Argatroban and Argatroban (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)