DDInter1826 DDInter504
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
Tolazamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Desipramine
Tolazamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Tolazamide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Promazine {u} (Compound) resembles {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Glyburide
Glyburide {u} (Compound) upregulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Alimemazine {u} (Compound) resembles {v} (Compound) Desipramine
Tolazamide {u} (Compound) resembles {v} (Compound) Gliclazide
Gliclazide {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Desipramine
Tolazamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Desipramine (Compound)
Tolazamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Protriptyline (Compound) and Protriptyline (Compound) resembles Desipramine (Compound)
Tolazamide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Epinastine (Compound) and Epinastine (Compound) resembles Desipramine (Compound)
Tolazamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Desipramine (Compound)
Tolazamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Desipramine (Compound)
Tolazamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Desipramine (Compound)
Tolazamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Desipramine (Compound)
Tolazamide (Compound) resembles Glyburide (Compound) and Glyburide (Compound) upregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Desipramine (Compound)
Tolazamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Desipramine (Compound)
Tolazamide (Compound) resembles Gliclazide (Compound) and Gliclazide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Desipramine (Compound)