DDInter162 DDInter593
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter indication was presented by Pernix Therapeutics.
Baclofen {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Thiothixene {u} (Compound) resembles {v} (Compound) Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Levodopa
Levodopa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Drug withdrawal syndrome
Drug withdrawal syndrome {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Suicide attempt
Suicide attempt {u} (Side Effect) is caused by {v} (Compound) Atomoxetine
Atomoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Ageusia
Ageusia {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may lead to a major life threatening interaction when taken with {v} Doxepin
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Baclofen {u} (Compound) causes {v} (Side Effect) Enuresis
Enuresis {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Aripiprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Baclofen (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxepin (Compound)
Baclofen (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Thiothixene (Compound) and Thiothixene (Compound) resembles Doxepin (Compound)
Baclofen (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Levodopa (Compound) and Levodopa may cause a minor interaction that can limit clinical effects when taken with Doxepin
Baclofen (Compound) causes Drug withdrawal syndrome (Side Effect) and Drug withdrawal syndrome (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Doxepin (Compound)
Baclofen (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Baclofen (Compound) causes Suicide attempt (Side Effect) and Suicide attempt (Side Effect) is caused by Atomoxetine (Compound) and Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Doxepin
Baclofen (Compound) causes Ageusia (Side Effect) and Ageusia (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine may lead to a major life threatening interaction when taken with Doxepin
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Baclofen (Compound) causes Enuresis (Side Effect) and Enuresis (Side Effect) is caused by Aripiprazole (Compound) and Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin