DDInter1215 DDInter255
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Mifepristone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Mifepristone {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Mifepristone {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Mifepristone {u} (Compound) causes {v} (Side Effect) Adrenal insufficiency
Adrenal insufficiency {u} (Side Effect) is caused by {v} (Compound) Busulfan
Mifepristone {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) DUSP11
DUSP11 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Mifepristone {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Mifepristone {u} (Compound) upregulates {v} (Gene) AARS
AARS {u} (Gene) is regulated by {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Mifepristone {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Mifepristone {u} (Compound) downregulates {v} (Gene) SACM1L
SACM1L {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Mifepristone {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Busulfan
Mifepristone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Mifepristone (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Busulfan (Compound)
Mifepristone (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Busulfan (Compound)
Mifepristone (Compound) causes Adrenal insufficiency (Side Effect) and Adrenal insufficiency (Side Effect) is caused by Busulfan (Compound)
Mifepristone (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates DUSP11 (Gene) and DUSP11 (Gene) is upregulated by Busulfan (Compound)
Mifepristone (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Mifepristone (Compound) upregulates AARS (Gene) and AARS (Gene) is regulated by PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Mifepristone (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)
Mifepristone (Compound) downregulates SACM1L (Gene) and SACM1L (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Mifepristone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Busulfan (Compound)