DDInter150 DDInter954
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, while the other 90% (beta radiation) causes tissue damage without contributing to any ability to see or image the isotope. Low levels of beta radiation are also known for causing cancer as this dose is highly mutagenic. For this reason, less toxic iodine isotopes such as I-123 are more frequently used in nuclear imaging, while I-131 is reserved for its tissue destroying effects. Because the thyroid gland naturally takes up iodine from the body, therapeutic methods using radioisotopes can take advantage of this mechanism for localization of drug to the site of malignancy. Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodine. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodine. It is also indicated for use in performance of the radioactive iodide (RAI) uptake test to evaluate thyroid function.
Azathioprine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) treats {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Quazepam
Quazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) is downregulated by {v} (Compound) Mebendazole
Mebendazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is downregulated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Levothyroxine
Levothyroxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Amiodarone
Amiodarone {u} may lead to a major life threatening interaction when taken with {v} Iodide I-131
Azathioprine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is upregulated by {v} (Compound) Mebendazole
Mebendazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Bacampicillin
Bacampicillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Azathioprine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) treats multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Quazepam (Compound) and Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Mebendazole (Compound) and Mebendazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is downregulated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Levothyroxine (Compound) and Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Amiodarone (Compound) and Amiodarone may lead to a major life threatening interaction when taken with Iodide I-131
Azathioprine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is upregulated by Mebendazole (Compound) and Mebendazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Azathioprine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Bacampicillin (Compound) and Bacampicillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131