DDInter154 DDInter981
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription drug on July 1st, 1959.
Azelastine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Lacosamide
Lacosamide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenacemide
Phenacemide {u} (Compound) resembles {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Metamfetamine
Metamfetamine {u} (Compound) resembles {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Isocarboxazid
Azelastine {u} (Compound) downregulates {v} (Gene) C1QBP
C1QBP {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Isocarboxazid
Azelastine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)
Azelastine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Isocarboxazid (Compound)
Azelastine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Lacosamide (Compound) and Lacosamide (Compound) resembles Isocarboxazid (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Isocarboxazid (Compound)
Azelastine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Metamfetamine (Compound) and Metamfetamine (Compound) resembles Isocarboxazid (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Isocarboxazid (Compound)
Azelastine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Isocarboxazid (Compound)
Azelastine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)
Azelastine (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by MAOB (Gene) and MAOB (Gene) is bound by Isocarboxazid (Compound)
Azelastine (Compound) downregulates C1QBP (Gene) and C1QBP (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Isocarboxazid (Compound)