DDInter292 DDInter704
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Captopril {u} (Compound) downregulates {v} (Gene) SLC25A4
SLC25A4 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Captopril {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Everolimus
Captopril {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Everolimus
Captopril {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Everolimus
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Captopril {u} (Compound) downregulates {v} (Gene) SLC25A4
SLC25A4 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is regulated by {v} (Gene) USP20
USP20 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Captopril {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) is regulated by {v} (Gene) BTG1
BTG1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Captopril {u} (Compound) downregulates {v} (Gene) TRIB1
TRIB1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Captopril (Compound) downregulates SLC25A4 (Gene) and SLC25A4 (Gene) is upregulated by Everolimus (Compound)
Captopril (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Everolimus (Compound)
Captopril (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Everolimus (Compound)
Captopril (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Everolimus (Compound)
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Captopril (Compound) downregulates SLC25A4 (Gene) and SLC25A4 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Everolimus (Compound)
Captopril (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is regulated by USP20 (Gene) and USP20 (Gene) is upregulated by Everolimus (Compound)
Captopril (Compound) upregulates RELB (Gene) and RELB (Gene) is regulated by BTG1 (Gene) and BTG1 (Gene) is upregulated by Everolimus (Compound)
Captopril (Compound) downregulates TRIB1 (Gene) and TRIB1 (Gene) is upregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)