DDInter548 DDInter1844
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} may lead to a major life threatening interaction when taken with {v} Tranexamic acid
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} may lead to a major life threatening interaction when taken with {v} Tranexamic acid
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) causes {v} (Side Effect) Haemoglobin
Haemoglobin {u} (Side Effect) is caused by {v} (Compound) Tranexamic acid
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Estradiol
Estradiol {u} may lead to a major life threatening interaction when taken with {v} Tranexamic acid
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may lead to a major life threatening interaction when taken with {v} Toremifene
Toremifene {u} may lead to a major life threatening interaction when taken with {v} Tranexamic acid
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR2
ESR2 {u} (Gene) is bound by {v} (Compound) Conjugated estrogens
Conjugated estrogens {u} may lead to a major life threatening interaction when taken with {v} Tranexamic acid
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR1
ESR1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) KRT18
KRT18 {u} (Gene) is downregulated by {v} (Compound) Tranexamic acid
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ESR2
ESR2 {u} (Gene) regulates {v} (Gene) PFN1
PFN1 {u} (Gene) is downregulated by {v} (Compound) Tranexamic acid
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tranexamic acid
Diethylstilbestrol {u} (Compound) upregulates {v} (Gene) CCP110
CCP110 {u} (Gene) is upregulated by {v} (Compound) Estradiol
Estradiol {u} may lead to a major life threatening interaction when taken with {v} Tranexamic acid
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Tranexamic acid
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may lead to a major life threatening interaction when taken with Tranexamic acid
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Tranexamic acid (Compound)
Diethylstilbestrol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Estradiol (Compound) and Estradiol may lead to a major life threatening interaction when taken with Tranexamic acid
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may lead to a major life threatening interaction when taken with Toremifene and Toremifene may lead to a major life threatening interaction when taken with Tranexamic acid
Diethylstilbestrol (Compound) binds ESR2 (Gene) and ESR2 (Gene) is bound by Conjugated estrogens (Compound) and Conjugated estrogens may lead to a major life threatening interaction when taken with Tranexamic acid
Diethylstilbestrol (Compound) binds ESR1 (Gene) and ESR1 (Gene) interacts with KRT18 (Gene) and ESR1 (Gene) regulates KRT18 (Gene) and KRT18 (Gene) is downregulated by Tranexamic acid (Compound)
Diethylstilbestrol (Compound) binds ESR2 (Gene) and ESR2 (Gene) regulates PFN1 (Gene) and PFN1 (Gene) is downregulated by Tranexamic acid (Compound)
Diethylstilbestrol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound) and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Tranexamic acid
Diethylstilbestrol (Compound) upregulates CCP110 (Gene) and CCP110 (Gene) is upregulated by Estradiol (Compound) and Estradiol may lead to a major life threatening interaction when taken with Tranexamic acid