DDInter255 DDInter783
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fosphenytoin
Busulfan {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Fosphenytoin
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fosphenytoin
Busulfan {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Fosphenytoin
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Fosphenytoin
Busulfan {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Busulfan {u} (Compound) causes {v} (Side Effect) Ileus
Ileus {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fosphenytoin
Busulfan {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Doxapram
Doxapram {u} (Compound) resembles {v} (Compound) Fosphenytoin
Busulfan {u} (Compound) causes {v} (Side Effect) Cardiomegaly
Cardiomegaly {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Busulfan {u} (Compound) binds {v} (Gene) MGST2
MGST2 {u} (Gene) is downregulated by {v} (Compound) Bortezomib
Bortezomib {u} may lead to a major life threatening interaction when taken with {v} Fosphenytoin
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Busulfan (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Fosphenytoin (Compound)
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Modafinil (Compound) and Modafinil (Compound) resembles Fosphenytoin (Compound)
Busulfan (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Fosphenytoin
Busulfan (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Busulfan (Compound) causes Ileus (Side Effect) and Ileus (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Fosphenytoin
Busulfan (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Doxapram (Compound) and Doxapram (Compound) resembles Fosphenytoin (Compound)
Busulfan (Compound) causes Cardiomegaly (Side Effect) and Cardiomegaly (Side Effect) is caused by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Busulfan (Compound) binds MGST2 (Gene) and MGST2 (Gene) is downregulated by Bortezomib (Compound) and Bortezomib may lead to a major life threatening interaction when taken with Fosphenytoin