DDInter78 DDInter927
Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Inotuzumab ozogamicin is an antibody-drug conjugate using linker and cytotoxic drug technology similar to that developed for the ground-breaking treatment Mylotarg (), which was approved by the US FDA in 2000 for the treatment of acute myeloid leukaemia. Inotuzumab ozogamicin consists of a recombinant humanised IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide, which is a potent DNA-binding cytotoxic agent . Developed by Pfizer and UCB, inotuzumab ozogamicin was granted approval by EU in June 2017 followed by FDA on August 17th, 2017 for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). ALL is a rapidly progressing cancer of the bone marrow that is associated with high mortality rates and low therapeutic response from standard chemotherapies in relasping conditions. In a randomized trial, inotuzumab ozogamicin displayed higher percentages of patients undergoing longer periods of complete remission with no evidence of disease in comparison to patients receiving alternative chemotherapy .
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Amitriptyline {u} (Compound) resembles {v} (Compound) Pheniramine
Amitriptyline {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Amitriptyline {u} (Compound) treats {v} (Disease) migraine
Amitriptyline {u} (Compound) binds {v} (Gene) KCNQ2
Amitriptyline {u} (Compound) upregulates {v} (Gene) PPP1R13B
Amitriptyline {u} (Compound) palliates {v} (Disease) multiple sclerosis
Amitriptyline {u} (Compound) downregulates {v} (Gene) NUP85
Amitriptyline {u} (Compound) causes {v} (Side Effect) Tinnitus
Amitriptyline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Amitriptyline (Compound) resembles Pheniramine (Compound)
Amitriptyline (Compound) resembles Bromodiphenhydramine (Compound)
Amitriptyline (Compound) treats migraine (Disease)
Amitriptyline (Compound) binds KCNQ2 (Gene)
Amitriptyline (Compound) upregulates PPP1R13B (Gene)
Amitriptyline (Compound) palliates multiple sclerosis (Disease)
Amitriptyline (Compound) downregulates NUP85 (Gene)
Amitriptyline (Compound) causes Tinnitus (Side Effect)
Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole