DDInter148 DDInter875
Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis. The other one is through the inhibition of DNA methyltransferase, impairing DNA methylation. Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA, azacytidine has been used mainly used in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), two types of cancer characterized by the presence of aberrant DNA methylation.[
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and self-assembled into VLPs.
Azacitidine {u} (Compound) resembles {v} (Compound) Adenosine
Azacitidine {u} (Compound) resembles {v} (Compound) S-Adenosylmethionine
Azacitidine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Azacitidine {u} (Compound) binds {v} (Gene) DNMT3A
Azacitidine {u} (Compound) upregulates {v} (Gene) FOXJ3
Azacitidine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Azacitidine {u} (Compound) downregulates {v} (Gene) ANXA2
Azacitidine {u} (Compound) causes {v} (Side Effect) Neck pain
Azacitidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Candida albicans
Azacitidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Efalizumab
Azacitidine (Compound) resembles Adenosine (Compound)
Azacitidine (Compound) resembles S-Adenosylmethionine (Compound)
Azacitidine may lead to a major life threatening interaction when taken with Cladribine
Azacitidine (Compound) binds DNMT3A (Gene)
Azacitidine (Compound) upregulates FOXJ3 (Gene)
Azacitidine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Azacitidine (Compound) downregulates ANXA2 (Gene)
Azacitidine (Compound) causes Neck pain (Side Effect)
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab