DDInter856 DDInter1833
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Tolvaptan {u} (Compound) resembles {v} (Compound) Conivaptan
Tolvaptan {u} (Compound) binds {v} (Gene) AVPR1A
Tolvaptan {u} (Compound) causes {v} (Side Effect) Renal impairment
Tolvaptan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Tolvaptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Empagliflozin
Tolvaptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Tolvaptan {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Tolvaptan {u} may lead to a major life threatening interaction when taken with {v} Lumacaftor
Tolvaptan (Compound) resembles Conivaptan (Compound)
Tolvaptan (Compound) binds AVPR1A (Gene)
Tolvaptan (Compound) causes Renal impairment (Side Effect)
Tolvaptan may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Tolvaptan may lead to a major life threatening interaction when taken with Leflunomide
Tolvaptan may lead to a major life threatening interaction when taken with Lumacaftor