DDInter1956 DDInter1789
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Zalcitabine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Thalidomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Musculoskeletal stiffness
Musculoskeletal stiffness {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Zalcitabine {u} (Compound) resembles {v} (Compound) Cytarabine
Cytarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Zalcitabine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) GRB7
GRB7 {u} (Gene) is downregulated by {v} (Compound) Thalidomide
Zalcitabine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Musculoskeletal stiffness
Musculoskeletal stiffness {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Thalidomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Nail disorder
Nail disorder {u} (Side Effect) is caused by {v} (Compound) Saquinavir
Saquinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Neuralgia
Neuralgia {u} (Side Effect) is caused by {v} (Compound) Tizanidine
Tizanidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} (Compound) causes {v} (Side Effect) Hepatomegaly
Hepatomegaly {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Zalcitabine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Zalcitabine (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Zalcitabine (Compound) resembles Cytarabine (Compound) and Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Cytarabine may lead to a major life threatening interaction when taken with Thalidomide
Zalcitabine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates GRB7 (Gene) and GRB7 (Gene) is downregulated by Thalidomide (Compound)
Zalcitabine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Zalcitabine (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Thalidomide (Compound)
Zalcitabine (Compound) causes Nail disorder (Side Effect) and Nail disorder (Side Effect) is caused by Saquinavir (Compound) and Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Zalcitabine (Compound) causes Neuralgia (Side Effect) and Neuralgia (Side Effect) is caused by Tizanidine (Compound) and Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine (Compound) causes Hepatomegaly (Side Effect) and Hepatomegaly (Side Effect) is caused by Thalidomide (Compound)