DDInter1851 DDInter154
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of depression. A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy. Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters. It was initially granted FDA approval in 1981.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Trazodone {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Azelastine
Trazodone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Trazodone {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) EPCAM
EPCAM {u} (Gene) is upregulated by {v} (Compound) Azelastine
Trazodone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Trazodone (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Trazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Azelastine (Compound)
Trazodone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Trazodone (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Azelastine (Compound)
Trazodone (Compound) resembles Clozapine (Compound) and Clozapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Trazodone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clozapine (Compound) and Clozapine (Compound) resembles Azelastine (Compound)
Trazodone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates EPCAM (Gene) and EPCAM (Gene) is upregulated by Azelastine (Compound)
Trazodone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)