DDInter1008 DDInter813
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
Ketoconazole {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Hepatobiliary disease
Hepatobiliary disease {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Ketoconazole {u} (Compound) resembles {v} (Compound) Itraconazole
Itraconazole {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Hepatitis cholestatic
Hepatitis cholestatic {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Electrocardiogram QT prolonged
Electrocardiogram QT prolonged {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Ketoconazole {u} (Compound) resembles {v} (Compound) Posaconazole
Posaconazole {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Swelling face
Swelling face {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Ketoconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Betamethasone
Betamethasone {u} may lead to a major life threatening interaction when taken with {v} Gemifloxacin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Electrocardiogram QT prolonged
Electrocardiogram QT prolonged {u} (Side Effect) is caused by {v} (Compound) Famotidine
Famotidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gemifloxacin
Ketoconazole (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Gemifloxacin (Compound)
Ketoconazole (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Ketoconazole (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gemifloxacin (Compound)
Ketoconazole (Compound) resembles Itraconazole (Compound) and Itraconazole (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Gemifloxacin (Compound)
Ketoconazole (Compound) causes Hepatitis cholestatic (Side Effect) and Hepatitis cholestatic (Side Effect) is caused by Capecitabine (Compound) and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Ketoconazole (Compound) causes Electrocardiogram QT prolonged (Side Effect) and Electrocardiogram QT prolonged (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin
Ketoconazole (Compound) resembles Posaconazole (Compound) and Posaconazole (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Gemifloxacin (Compound)
Ketoconazole (Compound) causes Swelling face (Side Effect) and Swelling face (Side Effect) is caused by Paclitaxel (Compound) and Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Ketoconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Betamethasone (Compound) and Betamethasone may lead to a major life threatening interaction when taken with Gemifloxacin
Ketoconazole (Compound) causes Electrocardiogram QT prolonged (Side Effect) and Electrocardiogram QT prolonged (Side Effect) is caused by Famotidine (Compound) and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Gemifloxacin