DDInter690 DDInter1124
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Ethanol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sertraline
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP4A11
CYP4A11 {u} (Gene) is bound by {v} (Compound) Pentamidine
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Flumazenil
Flumazenil {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) GRIN3A
GRIN3A {u} (Gene) regulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Ethanol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Maprotiline (Compound)
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline
Ethanol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sertraline (Compound) and Sertraline (Compound) resembles Maprotiline (Compound)
Ethanol (Compound) binds CYP4A11 (Gene) and CYP4A11 (Gene) is bound by Pentamidine (Compound) and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline
Ethanol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Imipramine (Compound) and Imipramine (Compound) resembles Maprotiline (Compound)
Ethanol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Maprotiline
Ethanol (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) is bound by Flumazenil (Compound) and Flumazenil may lead to a major life threatening interaction when taken with Maprotiline
Ethanol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Maprotiline (Compound)
Ethanol (Compound) binds GRIN3A (Gene) and GRIN3A (Gene) regulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Maprotiline (Compound)
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Cisapride (Compound) and Cisapride may lead to a major life threatening interaction when taken with Maprotiline