DDInter56 DDInter856
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin.[A252330,L43125] Alteplase is a purified glycoprotein of 527 amino acids expressed in Chinese hamster ovary (CHO) cells.[A252345,L43125] It was first approved by the FDA in 1987 for the management of thromboembolic disease, including acute myocardial infarction (AMI). The use of alteplase to manage AMI has decreased thanks to the availability of safer treatments such as angioplasty and stenting. However, its use for the treatment of acute ischem
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Alteplase {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Alteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ticlopidine
Alteplase {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Alteplase {u} may lead to a major life threatening interaction when taken with {v} Lepirudin
Alteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine
Alteplase may lead to a major life threatening interaction when taken with Desirudin
Alteplase may lead to a major life threatening interaction when taken with Lepirudin