DDInter1254 DDInter69
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.
A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Nabumetone {u} (Compound) resembles {v} (Compound) Melatonin
Nabumetone {u} (Compound) binds {v} (Gene) MPO
Nabumetone {u} (Compound) palliates {v} (Disease) osteoarthritis
Nabumetone {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nabumetone {u} (Compound) downregulates {v} (Gene) DNAJA3
Nabumetone {u} (Compound) causes {v} (Side Effect) Pruritus
Nabumetone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Nabumetone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Nabumetone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alteplase
Nabumetone (Compound) resembles Naproxen (Compound)
Nabumetone (Compound) resembles Melatonin (Compound)
Nabumetone (Compound) binds MPO (Gene)
Nabumetone (Compound) palliates osteoarthritis (Disease)
Nabumetone (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Nabumetone (Compound) downregulates DNAJA3 (Gene)
Nabumetone (Compound) causes Pruritus (Side Effect)
Nabumetone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Alteplase