DDInter458 DDInter513
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) downregulates {v} (Gene) SRSF2
SRSF2 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) upregulates {v} (Gene) SLC2A10
SLC2A10 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) downregulates {v} (Gene) AURKB
AURKB {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Trauma
Trauma {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Dexamethasone (Compound)
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Dexamethasone (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Dexamethasone (Compound)
Cyclosporine (Compound) downregulates SRSF2 (Gene) and SRSF2 (Gene) is upregulated by Dexamethasone (Compound)
Cyclosporine (Compound) upregulates SLC2A10 (Gene) and SLC2A10 (Gene) is downregulated by Dexamethasone (Compound)
Cyclosporine (Compound) downregulates AURKB (Gene) and AURKB (Gene) is downregulated by Dexamethasone (Compound)
Cyclosporine (Compound) causes Trauma (Side Effect) and Trauma (Side Effect) is caused by Dexamethasone (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Dexamethasone (Compound)
Cyclosporine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Paclitaxel (Compound) and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone