DDInter548 DDInter705
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is bound by {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is bound by {v} (Compound) Testolactone
Testolactone {u} (Compound) resembles {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exemestane
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) upregulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prednisolone
Prednisolone {u} (Compound) resembles {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Conjugated estrogens
Conjugated estrogens {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exemestane
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Exemestane
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exemestane
Diethylstilbestrol (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Exemestane (Compound)
Diethylstilbestrol (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Testolactone (Compound) and Testolactone (Compound) resembles Exemestane (Compound)
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Exemestane
Diethylstilbestrol (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Exemestane (Compound)
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Prednisolone (Compound) resembles Exemestane (Compound)
Diethylstilbestrol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Conjugated estrogens (Compound) and Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Exemestane
Diethylstilbestrol (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Exemestane (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Exemestane (Compound)
Diethylstilbestrol (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Exemestane (Compound)
Diethylstilbestrol (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Exemestane