DDInter188 DDInter535
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Benzthiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) resembles {v} (Compound) Metolazone
Metolazone {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) binds {v} (Gene) SLC12A3
SLC12A3 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) resembles {v} (Compound) Bendroflumethiazide
Bendroflumethiazide {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Benzthiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Benzthiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Benzthiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Benzthiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Benzthiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Benzthiazide (Compound) resembles Metolazone (Compound) and Metolazone (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Benzthiazide (Compound) binds CA2 (Gene) and CA2 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Benzthiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Benzthiazide (Compound) binds SLC12A3 (Gene) and SLC12A3 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Benzthiazide (Compound) resembles Bendroflumethiazide (Compound) and Bendroflumethiazide (Compound) treats hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Benzthiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)