DDInter576 DDInter1526
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Disulfiram {u} (Compound) upregulates {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Procarbazine
Disulfiram {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Disulfiram {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Procarbazine
Disulfiram {u} (Compound) upregulates {v} (Gene) MOK
MOK {u} (Gene) is regulated by {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Disulfiram {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) regulates {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Procarbazine
Disulfiram {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is regulated by {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Disulfiram {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Atenolol
Atenolol {u} (Compound) resembles {v} (Compound) Procarbazine
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Procarbazine
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Citalopram
Citalopram {u} may lead to a major life threatening interaction when taken with {v} Procarbazine
Disulfiram {u} (Compound) upregulates {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Digoxin
Digoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procarbazine
Disulfiram (Compound) upregulates MOK (Gene) and MOK (Gene) is upregulated by Procarbazine (Compound)
Disulfiram (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Disulfiram (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Disulfiram (Compound) upregulates MOK (Gene) and MOK (Gene) is regulated by DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Disulfiram (Compound) downregulates DLD (Gene) and DLD (Gene) regulates MOK (Gene) and MOK (Gene) is upregulated by Procarbazine (Compound)
Disulfiram (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is regulated by DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Disulfiram (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Atenolol (Compound) and Atenolol (Compound) resembles Procarbazine (Compound)
Disulfiram (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Citalopram (Compound) and Citalopram may lead to a major life threatening interaction when taken with Procarbazine
Disulfiram (Compound) upregulates MOK (Gene) and MOK (Gene) is upregulated by Digoxin (Compound) and Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine