DDInter1053 DDInter1960
Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Levocetirizine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Levocetirizine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Levocetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-123
Levocetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Levocetirizine may cause a minor interaction that can limit clinical effects when taken with Theophylline
Levocetirizine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine