DDInter458 DDInter580
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDCA4
CDCA4 {u} (Gene) is downregulated by {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CTSD
CTSD {u} (Gene) is downregulated by {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dronedarone
Dronedarone {u} (Compound) resembles {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDCA4
CDCA4 {u} (Gene) is regulated by {v} (Gene) CASP7
CASP7 {u} (Gene) is upregulated by {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CTSD
CTSD {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dofetilide
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CDCA4
CDCA4 {u} (Gene) is downregulated by {v} (Compound) Dofetilide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dofetilide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Dronedarone
Dronedarone {u} (Compound) resembles {v} (Compound) Dofetilide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dofetilide (Compound)
Cyclosporine (Compound) downregulates CDCA4 (Gene) and CDCA4 (Gene) is downregulated by Dofetilide (Compound)
Cyclosporine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is downregulated by Dofetilide (Compound)
Cyclosporine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Dofetilide (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound) and Dronedarone (Compound) resembles Dofetilide (Compound)
Cyclosporine (Compound) downregulates CDCA4 (Gene) and CDCA4 (Gene) is regulated by CASP7 (Gene) and CASP7 (Gene) is upregulated by Dofetilide (Compound)
Cyclosporine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Dofetilide
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CDCA4 (Gene) and CDCA4 (Gene) is downregulated by Dofetilide (Compound)
Cyclosporine (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dofetilide
Cyclosporine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Dronedarone (Compound) and Dronedarone (Compound) resembles Dofetilide (Compound)