DDInter336 DDInter1168
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Sucralfate
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methdilazine
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Nasopharyngitis
Nasopharyngitis {u} (Side Effect) is caused by {v} (Compound) Saxagliptin
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Celecoxib {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Mirtazapine
Mirtazapine {u} (Compound) resembles {v} (Compound) Methdilazine
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Celecoxib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Celecoxib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Sucralfate (Compound) and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Methdilazine
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Celecoxib (Compound) causes Nasopharyngitis (Side Effect) and Nasopharyngitis (Side Effect) is caused by Saxagliptin (Compound) and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Celecoxib (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Mirtazapine (Compound) and Mirtazapine (Compound) resembles Methdilazine (Compound)
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is upregulated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine