DDInter1447 DDInter690
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Phentermine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methadone
Methadone {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Fluvoxamine
Fluvoxamine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Tramadol
Tramadol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine {u} (Compound) resembles {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Selegiline
Selegiline {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is associated with {v} (Gene) ADH1B
ADH1B {u} (Gene) is bound by {v} (Compound) Ethanol
Phentermine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ethanol (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Phentermine may lead to a major life threatening interaction when taken with Fluvoxamine and Fluvoxamine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Phentermine may lead to a major life threatening interaction when taken with Tramadol and Tramadol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Phentermine (Compound) resembles Benzyl alcohol (Compound) and Benzyl alcohol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Phentermine (Compound) resembles Selegiline (Compound) and Phentermine may lead to a major life threatening interaction when taken with Selegiline and Selegiline (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Phentermine (Compound) treats obesity (Disease) and obesity (Disease) is associated with ADH1B (Gene) and ADH1B (Gene) is bound by Ethanol (Compound)