DDInter932 DDInter1397
Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis. Insulin is an important treatment in the management of Type 1 Diabetes (T1D), which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Insulin glargine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amcinonide
Amcinonide {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phentolamine
Phentolamine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Potassium chloride
Potassium chloride {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Ethionamide {u} (Compound) downregulates {v} (Gene) SUZ12
SUZ12 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levonorgestrel
Levonorgestrel {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Amcinonide
Amcinonide {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Liotrix
Liotrix {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Losartan
Losartan {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risperidone
Risperidone {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Paroxetine (Compound)
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Phentolamine and Phentolamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Paroxetine (Compound)
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Potassium chloride and Potassium chloride (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Paroxetine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide (Compound) downregulates SUZ12 (Gene) and SUZ12 (Gene) is downregulated by Paroxetine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Paroxetine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Paroxetine (Compound)
Insulin glargine may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Paroxetine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Paroxetine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is downregulated by Paroxetine (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Paroxetine (Compound)