DDInter507 DDInter1397
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH. It has been employed clinically since 1972
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Desmopressin {u} (Compound) causes {v} (Side Effect) Inappropriate antidiuretic hormone secretion
Inappropriate antidiuretic hormone secretion {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Desmopressin {u} (Compound) resembles {v} (Compound) Terlipressin
Terlipressin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Desmopressin {u} (Compound) resembles {v} (Compound) Gonadorelin
Gonadorelin {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Desmopressin {u} (Compound) resembles {v} (Compound) Vapreotide
Vapreotide {u} (Compound) binds {v} (Gene) TACR1
TACR1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Desmopressin {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Desmopressin {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) downregulates {v} (Gene) DDX10
DDX10 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) KIAA0907
KIAA0907 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Desmopressin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) binds {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) binds {v} (Gene) CHRM5
CHRM5 {u} (Gene) is bound by {v} (Compound) Paroxetine
Desmopressin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Desmopressin (Compound) causes Inappropriate antidiuretic hormone secretion (Side Effect) and Inappropriate antidiuretic hormone secretion (Side Effect) is caused by Paroxetine (Compound)
Desmopressin (Compound) resembles Terlipressin (Compound) and Terlipressin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Paroxetine (Compound)
Desmopressin (Compound) resembles Gonadorelin (Compound) and Gonadorelin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Paroxetine (Compound)
Desmopressin (Compound) resembles Vapreotide (Compound) and Vapreotide (Compound) binds TACR1 (Gene) and TACR1 (Gene) is bound by Paroxetine (Compound)
Desmopressin (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Desmopressin (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) downregulates DDX10 (Gene) and DDX10 (Gene) is downregulated by Paroxetine (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by KIAA0907 (Gene) and KIAA0907 (Gene) is upregulated by Paroxetine (Compound)
Desmopressin may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) binds NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Paroxetine (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) binds CHRM5 (Gene) and CHRM5 (Gene) is bound by Paroxetine (Compound)
Desmopressin may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)