DDInter842 DDInter178
Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Grepafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Denileukin diftitox
Grepafloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Semaglutide
Grepafloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Caffeine
Grepafloxacin {u} may lead to a major life threatening interaction when taken with {v} Encorafenib
Grepafloxacin {u} may lead to a major life threatening interaction when taken with {v} Insulin glargine
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Denileukin diftitox
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Caffeine
Grepafloxacin may lead to a major life threatening interaction when taken with Encorafenib
Grepafloxacin may lead to a major life threatening interaction when taken with Insulin glargine