DDInter1632 DDInter119
Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma,
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Salbutamol {u} (Compound) resembles {v} (Compound) Terbutaline
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epinephrine
Salbutamol {u} (Compound) resembles {v} (Compound) Clenbuterol
Salbutamol {u} may lead to a major life threatening interaction when taken with {v} Levobunolol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Salbutamol {u} (Compound) treats {v} (Disease) asthma
Salbutamol {u} (Compound) binds {v} (Gene) ADRB1
Salbutamol {u} (Compound) palliates {v} (Disease) allergic rhinitis
Salbutamol {u} (Compound) is included by {v} (Pharmacologic Class) Adrenergic beta2-Agonists
Salbutamol {u} (Compound) causes {v} (Side Effect) Asthenia
Salbutamol (Compound) resembles Terbutaline (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Salbutamol (Compound) resembles Clenbuterol (Compound)
Salbutamol may lead to a major life threatening interaction when taken with Levobunolol
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Salbutamol (Compound) treats asthma (Disease)
Salbutamol (Compound) binds ADRB1 (Gene)
Salbutamol (Compound) palliates allergic rhinitis (Disease)
Salbutamol (Compound) is included by Adrenergic beta2-Agonists (Pharmacologic Class)
Salbutamol (Compound) causes Asthenia (Side Effect)