DDInter1834 DDInter45
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
A phenothiazine derivative that is used as an antipruritic.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Alimemazine
Topiramate {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Alimemazine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Topiramate {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Topiramate {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Alimemazine
Topiramate {u} (Compound) causes {v} (Side Effect) Akinesia
Akinesia {u} (Side Effect) is caused by {v} (Compound) Propericiazine
Propericiazine {u} (Compound) resembles {v} (Compound) Alimemazine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Alimemazine
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Topiramate {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Alimemazine
Topiramate {u} (Compound) causes {v} (Side Effect) Akinesia
Akinesia {u} (Side Effect) is caused by {v} (Compound) Molindone
Molindone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alimemazine (Compound)
Topiramate (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Alimemazine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Topiramate (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Topiramate (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Alimemazine (Compound)
Topiramate (Compound) causes Akinesia (Side Effect) and Akinesia (Side Effect) is caused by Propericiazine (Compound) and Propericiazine (Compound) resembles Alimemazine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Alimemazine (Compound)
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Topiramate (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Alimemazine
Topiramate (Compound) causes Akinesia (Side Effect) and Akinesia (Side Effect) is caused by Molindone (Compound) and Molindone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine