DDInter1853 DDInter72
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Tretinoin {u} (Compound) upregulates {v} (Gene) POLD4
POLD4 {u} (Gene) is upregulated by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) downregulates {v} (Gene) SPDEF
SPDEF {u} (Gene) is upregulated by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) downregulates {v} (Gene) PRR7
PRR7 {u} (Gene) is downregulated by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) upregulates {v} (Gene) TRIB1
TRIB1 {u} (Gene) is downregulated by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Aminolevulinic acid
Tretinoin {u} (Compound) upregulates {v} (Gene) POLD4
POLD4 {u} (Gene) is regulated by {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) POLD4
POLD4 {u} (Gene) is upregulated by {v} (Compound) Aminolevulinic acid
Tretinoin {u} (Compound) downregulates {v} (Gene) SPDEF
SPDEF {u} (Gene) regulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is upregulated by {v} (Compound) Aminolevulinic acid
Tretinoin (Compound) upregulates POLD4 (Gene) and POLD4 (Gene) is upregulated by Aminolevulinic acid (Compound)
Tretinoin (Compound) downregulates SPDEF (Gene) and SPDEF (Gene) is upregulated by Aminolevulinic acid (Compound)
Tretinoin (Compound) downregulates PRR7 (Gene) and PRR7 (Gene) is downregulated by Aminolevulinic acid (Compound)
Tretinoin (Compound) upregulates TRIB1 (Gene) and TRIB1 (Gene) is downregulated by Aminolevulinic acid (Compound)
Tretinoin (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Aminolevulinic acid (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Iso
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Aminolevulinic acid
Tretinoin (Compound) upregulates POLD4 (Gene) and POLD4 (Gene) is regulated by DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Aminolevulinic acid (Compound)
Tretinoin (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates POLD4 (Gene) and POLD4 (Gene) is upregulated by Aminolevulinic acid (Compound)
Tretinoin (Compound) downregulates SPDEF (Gene) and SPDEF (Gene) regulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Aminolevulinic acid (Compound)