DDInter1042 DDInter575
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Disopyramide {u} (Compound) resembles {v} (Compound) Dextropropoxyphene
Disopyramide {u} (Compound) resembles {v} (Compound) Isopropamide
Disopyramide {u} (Compound) binds {v} (Gene) CHRM2
Disopyramide {u} (Compound) upregulates {v} (Gene) KIAA0355
Disopyramide {u} (Compound) causes {v} (Side Effect) Cardiac arrest
Disopyramide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Disopyramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Disopyramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin human
Disopyramide {u} may lead to a major life threatening interaction when taken with {v} Entrectinib
Disopyramide {u} may lead to a major life threatening interaction when taken with {v} Abarelix
Disopyramide (Compound) resembles Dextropropoxyphene (Compound)
Disopyramide (Compound) resembles Isopropamide (Compound)
Disopyramide (Compound) binds CHRM2 (Gene)
Disopyramide (Compound) upregulates KIAA0355 (Gene)
Disopyramide (Compound) causes Cardiac arrest (Side Effect)
Disopyramide may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Insulin human
Disopyramide may lead to a major life threatening interaction when taken with Entrectinib
Disopyramide may lead to a major life threatening interaction when taken with Abarelix