DDInter1397 DDInter45
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
A phenothiazine derivative that is used as an antipruritic.
Paroxetine {u} (Compound) upregulates {v} (Gene) IDI1
IDI1 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Paroxetine {u} (Compound) downregulates {v} (Gene) DPH2
DPH2 {u} (Gene) is downregulated by {v} (Compound) Alimemazine
Paroxetine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Alimemazine
Paroxetine {u} (Compound) upregulates {v} (Gene) IDI1
IDI1 {u} (Gene) is regulated by {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Alimemazine
Paroxetine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) resembles {v} (Compound) Alimemazine
Paroxetine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is regulated by {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Paroxetine {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Alimemazine
Paroxetine {u} (Compound) downregulates {v} (Gene) DPH2
DPH2 {u} (Gene) is regulated by {v} (Gene) FDPS
FDPS {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Paroxetine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Alimemazine
Paroxetine {u} (Compound) downregulates {v} (Gene) CDC45
CDC45 {u} (Gene) is downregulated by {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Alimemazine
Paroxetine (Compound) upregulates IDI1 (Gene) and IDI1 (Gene) is upregulated by Alimemazine (Compound)
Paroxetine (Compound) downregulates DPH2 (Gene) and DPH2 (Gene) is downregulated by Alimemazine (Compound)
Paroxetine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Alimemazine (Compound)
Paroxetine (Compound) upregulates IDI1 (Gene) and IDI1 (Gene) is regulated by CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Alimemazine (Compound)
Paroxetine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Alimemazine (Compound)
Paroxetine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is regulated by ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Alimemazine (Compound)
Paroxetine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Promazine (Compound) and Promazine (Compound) resembles Alimemazine (Compound)
Paroxetine (Compound) downregulates DPH2 (Gene) and DPH2 (Gene) is regulated by FDPS (Gene) and FDPS (Gene) is upregulated by Alimemazine (Compound)
Paroxetine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Triflupromazine (Compound) and Triflupromazine (Compound) resembles Alimemazine (Compound)
Paroxetine (Compound) downregulates CDC45 (Gene) and CDC45 (Gene) is downregulated by Promazine (Compound) and Promazine (Compound) resembles Alimemazine (Compound)