DDInter458 DDInter718
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Fenofibrate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Fenofibrate
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Bezafibrate
Bezafibrate {u} (Compound) resembles {v} (Compound) Fenofibrate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Indomethacin {u} (Compound) resembles {v} (Compound) Fenofibrate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Herpes simplex
Herpes simplex {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenofibrate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myopathy
Myopathy {u} (Side Effect) is caused by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may lead to a major life threatening interaction when taken with {v} Fenofibrate
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Zafirlukast
Zafirlukast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenofibrate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myopathy
Myopathy {u} (Side Effect) is caused by {v} (Compound) Simvastatin
Simvastatin {u} may lead to a major life threatening interaction when taken with {v} Fenofibrate
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Fenofibrate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Acne
Acne {u} (Side Effect) is caused by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenofibrate
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Fenofibrate (Compound)
Cyclosporine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Fenofibrate (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bezafibrate (Compound) and Bezafibrate (Compound) resembles Fenofibrate (Compound)
Cyclosporine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Indomethacin (Compound) and Indomethacin (Compound) resembles Fenofibrate (Compound)
Cyclosporine (Compound) causes Herpes simplex (Side Effect) and Herpes simplex (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Fenofibrate
Cyclosporine (Compound) causes Myopathy (Side Effect) and Myopathy (Side Effect) is caused by Rosuvastatin (Compound) and Rosuvastatin may lead to a major life threatening interaction when taken with Fenofibrate
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Zafirlukast (Compound) and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Fenofibrate
Cyclosporine (Compound) causes Myopathy (Side Effect) and Myopathy (Side Effect) is caused by Simvastatin (Compound) and Simvastatin may lead to a major life threatening interaction when taken with Fenofibrate
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Fenofibrate (Compound)
Cyclosporine (Compound) causes Acne (Side Effect) and Acne (Side Effect) is caused by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Fenofibrate