DDInter1305 DDInter1852
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcutaneous, intravenous, inhaled and oral. The first generic form of treprostinil became available in 2019.
Nitroprusside {u} (Compound) binds {v} (Gene) GUCY1A2
GUCY1A2 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) GUCY1A2
GUCY1A2 {u} (Gene) is bound by {v} (Compound) Isosorbide dinitrate
Isosorbide dinitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) S100A13
S100A13 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) ST7
ST7 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is regulated by {v} (Gene) DDX49
DDX49 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Treprostinil
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may lead to a major life threatening interaction when taken with {v} Treprostinil
Nitroprusside (Compound) binds GUCY1A2 (Gene) and GUCY1A2 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Treprostinil (Compound)
Nitroprusside (Compound) binds GUCY1A2 (Gene) and GUCY1A2 (Gene) is bound by Isosorbide dinitrate (Compound) and Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates S100A13 (Gene) and S100A13 (Gene) is upregulated by Treprostinil (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates ST7 (Gene) and ST7 (Gene) is downregulated by Treprostinil (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is regulated by DDX49 (Gene) and DDX49 (Gene) is downregulated by Treprostinil (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Treprostinil
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Treprostinil