DDInter557 DDInter1763
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) is regulated by {v} (Gene) MKNK1
MKNK1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) TNFRSF21
TNFRSF21 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergoloid mesylate
Ergoloid mesylate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) interacts with {v} (Gene) CDH3
CDH3 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) TNFRSF21
TNFRSF21 {u} (Gene) regulates {v} (Gene) MMP1
MMP1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) is upregulated by Temsirolimus (Compound)
Dihydroergotamine (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Temsirolimus (Compound)
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) is regulated by MKNK1 (Gene) and MKNK1 (Gene) is upregulated by Temsirolimus (Compound)
Dihydroergotamine (Compound) downregulates TNFRSF21 (Gene) and TNFRSF21 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Temsirolimus (Compound)
Dihydroergotamine (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Dihydroergotamine (Compound) resembles Ergoloid mesylate (Compound) and Ergoloid mesylate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) interacts with CDH3 (Gene) and CDH3 (Gene) is upregulated by Temsirolimus (Compound)
Dihydroergotamine (Compound) downregulates TNFRSF21 (Gene) and TNFRSF21 (Gene) regulates MMP1 (Gene) and MMP1 (Gene) is upregulated by Temsirolimus (Compound)