DDInter527 DDInter154
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Azelastine
Dextromethorphan {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Azelastine
Dextromethorphan {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Azelastine
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Azelastine
Dextromethorphan {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) EPCAM
EPCAM {u} (Gene) is upregulated by {v} (Compound) Azelastine
Dextromethorphan {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Azelastine
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Dextromethorphan (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Azelastine (Compound)
Dextromethorphan (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Azelastine (Compound)
Dextromethorphan (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Azelastine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Dextromethorphan (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clozapine (Compound) and Clozapine (Compound) resembles Azelastine (Compound)
Dextromethorphan (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates EPCAM (Gene) and EPCAM (Gene) is upregulated by Azelastine (Compound)
Dextromethorphan (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Azelastine (Compound)