DDInter743 DDInter557
Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Fluconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Fluconazole {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Dihydroergotamine
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Ergoloid mesylate
Ergoloid mesylate {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Fluconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Fluconazole {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylergometrine
Methylergometrine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Fluconazole {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylergometrine
Methylergometrine {u} (Compound) palliates {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Dihydroergotamine
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dihydroergotamine (Compound)
Fluconazole (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Dihydroergotamine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Ergoloid mesylate (Compound) and Ergoloid mesylate (Compound) resembles Dihydroergotamine (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ergotamine (Compound) and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Fluconazole (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Bromocriptine (Compound) and Bromocriptine (Compound) resembles Dihydroergotamine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and Methylergometrine (Compound) resembles Ergotamine (Compound) and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dihydroergotamine (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Methylergometrine and Methylergometrine (Compound) palliates migraine (Disease) and migraine (Disease) is palliated by Dihydroergotamine (Compound)