DDInter1263 DDInter690
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Methadone
Methadone {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Voriconazole
Voriconazole {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rifampicin
Rifampicin {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Tapentadol
Tapentadol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} (Compound) resembles {v} (Compound) Buprenorphine
Buprenorphine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Hydromorphone
Hydromorphone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Oxymorphone
Oxymorphone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} (Compound) resembles {v} (Compound) Naloxone
Naloxone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) ADH1B
ADH1B {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Ethanol
Naltrexone may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Naltrexone may lead to a major life threatening interaction when taken with Tapentadol and Tapentadol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Naltrexone (Compound) resembles Buprenorphine (Compound) and Buprenorphine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Naltrexone (Compound) resembles Hydromorphone (Compound) and Naltrexone may lead to a major life threatening interaction when taken with Hydromorphone and Hydromorphone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Naltrexone (Compound) resembles Oxymorphone (Compound) and Naltrexone may lead to a major life threatening interaction when taken with Oxymorphone and Oxymorphone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Naltrexone (Compound) resembles Naloxone (Compound) and Naloxone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Naltrexone (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is associated with ADH1B (Gene) and ADH1B (Gene) is bound by Ethanol (Compound)
Naltrexone (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Ethanol (Compound)