DDInter127 DDInter1266
Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginase from _E. coli_ has clinically shown to exhibit antitumor actions in models of leukaemias [A31996, A31997]. L-asparaginase of _E. coli_ is marketed under several different trade names, including Elspar, for the treatment of acute lymphoblastic leukemia (ALL) as part of a multi-agent chemotherapeutic regimen. It is available as intramuscular or intravenous injections. Therapeutic L-asparaginase from _E. coli_ works by depleting the levels
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) resembles {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rosuvastatin
Rosuvastatin {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Agomelatine
Agomelatine {u} (Compound) resembles {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfasalazine
Sulfasalazine {u} (Compound) treats {v} (Disease) ankylosing spondylitis
ankylosing spondylitis {u} (Disease) is palliated by {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rosuvastatin
Rosuvastatin {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Naproxen
Asparaginase Escherichia coli {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Naproxen
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Suprofen (Compound) and Suprofen (Compound) resembles Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Agomelatine (Compound) and Agomelatine (Compound) resembles Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) treats ankylosing spondylitis (Disease) and ankylosing spondylitis (Disease) is palliated by Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Naproxen (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) treats gout (Disease) and gout (Disease) is treated by Naproxen (Compound)