DDInter921 DDInter69
Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid. The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is the main enzyme responsible for catalyzes the rate-limiting step in prostaglandin and thromboxane biosynthesis via the arachidonic acid (AA) pathway. Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by
A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
Indomethacin {u} (Compound) resembles {v} (Compound) Agomelatine
Indomethacin {u} (Compound) resembles {v} (Compound) Fenofibrate
Indomethacin {u} (Compound) treats {v} (Disease) gout
Indomethacin {u} (Compound) binds {v} (Gene) PTGR2
Indomethacin {u} (Compound) upregulates {v} (Gene) TIAM1
Indomethacin {u} (Compound) palliates {v} (Disease) osteoarthritis
Indomethacin {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Indomethacin {u} (Compound) downregulates {v} (Gene) COG2
Indomethacin {u} (Compound) causes {v} (Side Effect) Sweating
Indomethacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Indomethacin (Compound) resembles Agomelatine (Compound)
Indomethacin (Compound) resembles Fenofibrate (Compound)
Indomethacin (Compound) treats gout (Disease)
Indomethacin (Compound) binds PTGR2 (Gene)
Indomethacin (Compound) upregulates TIAM1 (Gene)
Indomethacin (Compound) palliates osteoarthritis (Disease)
Indomethacin (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Indomethacin (Compound) downregulates COG2 (Gene)
Indomethacin (Compound) causes Sweating (Side Effect)
Indomethacin may cause a minor interaction that can limit clinical effects when taken with Cimetidine