DDInter1934 DDInter1082
Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug administration). Vilanterol was designed based on the salmeterol molecular scaffold, particularly as a antedrug analog of salmeterol modification by modifying the salmeterol molecule to create homochiral compounds with the (R)-configuration. Vilanterol is 1000 and 400 fold more selective for β2 than β1 and β3 adrenoceptors, respectively, with a faster onset of action than salmeterol. Additionally, vilanterol demonstrated a significantly longer duration of action than salmeterol, with the bronchodilator effect still apparent at 22h. Vilanterol
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Vilanterol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Vilanterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azithromycin
Vilanterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin degludec
Vilanterol {u} may lead to a major life threatening interaction when taken with {v} Macimorelin
Vilanterol {u} may lead to a major life threatening interaction when taken with {v} Carvedilol
Vilanterol may cause a minor interaction that can limit clinical effects when taken with Dexamethasone
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Vilanterol may lead to a major life threatening interaction when taken with Macimorelin
Vilanterol may lead to a major life threatening interaction when taken with Carvedilol