DDInter1470 DDInter1376
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Pimozide {u} (Compound) resembles {v} (Compound) Fexofenadine
Pimozide {u} (Compound) resembles {v} (Compound) Ezetimibe
Pimozide {u} may lead to a major life threatening interaction when taken with {v} Astemizole
Pimozide {u} (Compound) binds {v} (Gene) CALM3
Pimozide {u} (Compound) upregulates {v} (Gene) GNPDA1
Pimozide {u} (Compound) palliates {v} (Disease) Gilles de la Tourette syndrome
Pimozide {u} (Compound) downregulates {v} (Gene) TMEM109
Pimozide {u} (Compound) causes {v} (Side Effect) Hypertension
Pimozide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Pimozide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Pimozide (Compound) resembles Fexofenadine (Compound)
Pimozide (Compound) resembles Ezetimibe (Compound)
Pimozide may lead to a major life threatening interaction when taken with Astemizole
Pimozide (Compound) binds CALM3 (Gene)
Pimozide (Compound) upregulates GNPDA1 (Gene)
Pimozide (Compound) palliates Gilles de la Tourette syndrome (Disease)
Pimozide (Compound) downregulates TMEM109 (Gene)
Pimozide (Compound) causes Hypertension (Side Effect)
Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine