DDInter1033 DDInter134
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Leflunomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide {u} (Compound) binds {v} (Gene) DHODH
DHODH {u} (Gene) is bound by {v} (Compound) Atovaquone
Leflunomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Phenindione
Phenindione {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Acarbose
Acarbose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Azelastine
Azelastine {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Bicalutamide
Bicalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Simvastatin
Simvastatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atovaquone
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Bicalutamide
Bicalutamide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atovaquone
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Triamcinolone
Triamcinolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Leflunomide (Compound) binds DHODH (Gene) and DHODH (Gene) is bound by Atovaquone (Compound)
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Atovaquone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Leflunomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Azelastine (Compound) and Azelastine (Compound) resembles Atovaquone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atovaquone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Chenodeoxycholic acid and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atovaquone (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)