DDInter1042 DDInter1693
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate anhydrous is an electrolyte replenisher and is used in isosmotic solutions so that administration does not disturb normal electrolyte balance and does not lead to absorption or excretion of water and ions.
Sodium sulfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Sodium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxamniquine
Sodium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostemsavir
Sodium sulfate {u} may lead to a major life threatening interaction when taken with {v} Dronedarone
Sodium sulfate may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir
Sodium sulfate may lead to a major life threatening interaction when taken with Dronedarone