DDInter458 DDInter1442
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mental disability
Mental disability {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Secobarbital
Secobarbital {u} (Compound) resembles {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Phenobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Lethargy
Lethargy {u} (Side Effect) is caused by {v} (Compound) Lomustine
Lomustine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Cyclosporine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Phenobarbital (Compound)
Cyclosporine (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Phenobarbital (Compound)
Cyclosporine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Cyclosporine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Primidone (Compound) and Primidone (Compound) resembles Phenobarbital (Compound)
Cyclosporine (Compound) causes Mental disability (Side Effect) and Mental disability (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Phenobarbital (Compound)
Cyclosporine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Secobarbital (Compound) and Secobarbital (Compound) resembles Phenobarbital (Compound)
Cyclosporine (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Primidone (Compound) and Primidone (Compound) resembles Phenobarbital (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Phenobarbital (Compound)
Cyclosporine (Compound) causes Lethargy (Side Effect) and Lethargy (Side Effect) is caused by Lomustine (Compound) and Lomustine may cause a minor interaction that can limit clinical effects when taken with Phenobarbital