DDInter1266 DDInter645
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Naproxen {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Enoxaparin
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Naproxen {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Naproxen {u} (Compound) causes {v} (Side Effect) Skin necrosis
Skin necrosis {u} (Side Effect) is caused by {v} (Compound) Ardeparin
Ardeparin {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Nabumetone {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Enoxaparin
Naproxen {u} (Compound) resembles {v} (Compound) Indomethacin
Indomethacin {u} (Compound) causes {v} (Side Effect) Purpura
Purpura {u} (Side Effect) is caused by {v} (Compound) Enoxaparin
Naproxen {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is regulated by {v} (Gene) SERPINC1
SERPINC1 {u} (Gene) is bound by {v} (Compound) Enoxaparin
Naproxen {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Bismuth subsalicylate
Bismuth subsalicylate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Naproxen {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Enoxaparin
Naproxen {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Naproxen (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Naproxen (Compound) resembles Nabumetone (Compound) and Nabumetone may lead to a major life threatening interaction when taken with Enoxaparin
Naproxen (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Naproxen (Compound) causes Skin necrosis (Side Effect) and Skin necrosis (Side Effect) is caused by Ardeparin (Compound) and Ardeparin may lead to a major life threatening interaction when taken with Enoxaparin
Naproxen (Compound) resembles Nabumetone (Compound) and Nabumetone (Compound) binds MPO (Gene) and MPO (Gene) is bound by Enoxaparin (Compound)
Naproxen (Compound) resembles Indomethacin (Compound) and Indomethacin (Compound) causes Purpura (Side Effect) and Purpura (Side Effect) is caused by Enoxaparin (Compound)
Naproxen (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is regulated by SERPINC1 (Gene) and SERPINC1 (Gene) is bound by Enoxaparin (Compound)
Naproxen (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Bismuth subsalicylate (Compound) and Bismuth subsalicylate may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Naproxen (Compound) palliates rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with MPO (Gene) and MPO (Gene) is bound by Enoxaparin (Compound)
Naproxen (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin