DDInter1098 DDInter542
Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Lovastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Lovastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Lovastatin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Lovastatin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin {u} (Compound) resembles {v} (Compound) Pravastatin
Pravastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Dicoumarol
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Dicoumarol (Compound)
Lovastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dicoumarol (Compound)
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Dicoumarol (Compound)
Lovastatin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Dicoumarol (Compound)
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dicoumarol (Compound)
Lovastatin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Lovastatin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by NQO1 (Gene) and NQO1 (Gene) is bound by Dicoumarol (Compound)
Lovastatin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) resembles Dicoumarol (Compound)
Lovastatin (Compound) resembles Pravastatin (Compound) and Pravastatin may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) resembles Dicoumarol (Compound)