DDInter1513 DDInter535
Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Prednisolone {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Prednisolone {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Prednisolone {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is regulated by {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Prednisolone {u} (Compound) downregulates {v} (Gene) CDKN1B
CDKN1B {u} (Gene) regulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Prednisolone {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Prednisolone {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroflumethiazide
Hydroflumethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Prednisolone (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Diazoxide (Compound)
Prednisolone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Prednisolone (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is regulated by KRT19 (Gene) and KRT19 (Gene) is upregulated by Diazoxide (Compound)
Prednisolone (Compound) downregulates CDKN1B (Gene) and CDKN1B (Gene) regulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Prednisolone (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Prednisolone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)