DDInter162 DDInter1168
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Magnesium hydroxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methdilazine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorphenesin
Chlorphenesin {u} (Compound) resembles {v} (Compound) Bisoprolol
Bisoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Saxagliptin
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Procarbazine
Procarbazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen {u} (Compound) palliates {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is palliated by {v} (Compound) Amitriptyline
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Methdilazine
Baclofen (Compound) resembles Chlorphenesin (Compound) and Chlorphenesin (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Saxagliptin (Compound) and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Enalapril (Compound) and Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Procarbazine (Compound) and Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Baclofen (Compound) palliates multiple sclerosis (Disease) and multiple sclerosis (Disease) is palliated by Amitriptyline (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine