DDInter675 DDInter1244
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Esmolol {u} (Compound) causes {v} (Side Effect) Wheezing
Wheezing {u} (Side Effect) is caused by {v} (Compound) Morphine
Esmolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Esmolol {u} (Compound) resembles {v} (Compound) Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Esmolol {u} (Compound) resembles {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Esmolol {u} (Compound) causes {v} (Side Effect) Wheezing
Wheezing {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Esmolol {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Morphine
Esmolol {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Esmolol {u} (Compound) causes {v} (Side Effect) Pallor
Pallor {u} (Side Effect) is caused by {v} (Compound) Ephedrine
Ephedrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Morphine
Esmolol {u} (Compound) causes {v} (Side Effect) Blister
Blister {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Esmolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Morphine
Esmolol (Compound) causes Wheezing (Side Effect) and Wheezing (Side Effect) is caused by Morphine (Compound)
Esmolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Esmolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Esmolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Esmolol (Compound) causes Wheezing (Side Effect) and Wheezing (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone may lead to a major life threatening interaction when taken with Morphine
Esmolol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Galantamine (Compound) and Galantamine (Compound) resembles Morphine (Compound)
Esmolol (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Esmolol (Compound) causes Pallor (Side Effect) and Pallor (Side Effect) is caused by Ephedrine (Compound) and Ephedrine may cause a minor interaction that can limit clinical effects when taken with Morphine
Esmolol (Compound) causes Blister (Side Effect) and Blister (Side Effect) is caused by Indapamide (Compound) and Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Esmolol (Compound) resembles Metoprolol (Compound) and Metoprolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Morphine (Compound)