DDInter1852 DDInter535
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcut
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Treprostinil {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) upregulates {v} (Gene) ACOT9
ACOT9 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) regulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) upregulates {v} (Gene) LPAR2
LPAR2 {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is regulated by {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Treprostinil {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Treprostinil (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Diazoxide (Compound)
Treprostinil (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Diazoxide (Compound)
Treprostinil (Compound) upregulates ACOT9 (Gene) and ACOT9 (Gene) is downregulated by Diazoxide (Compound)
Treprostinil (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Treprostinil (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) regulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Treprostinil (Compound) upregulates LPAR2 (Gene) and LPAR2 (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is upregulated by Diazoxide (Compound)
Treprostinil (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is regulated by CEBPD (Gene) and CEBPD (Gene) is upregulated by Diazoxide (Compound)
Treprostinil (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)