DDInter781 DDInter150
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Fosinopril {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) binds {v} (Gene) ACE
ACE {u} (Gene) is associated with {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) upregulates {v} (Gene) GSTA2
GSTA2 {u} (Gene) is bound by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) regulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Fosinopril {u} (Compound) resembles {v} (Compound) Cilazapril
Cilazapril {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Fosinopril (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Fosinopril (Compound) binds ACE (Gene) and ACE (Gene) is associated with systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Azathioprine (Compound)
Fosinopril (Compound) treats hypertension (Disease) and hypertension (Disease) upregulates GSTA2 (Gene) and GSTA2 (Gene) is bound by Azathioprine (Compound)
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Fosinopril (Compound) upregulates SYNGR3 (Gene) and SYNGR3 (Gene) regulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Azathioprine (Compound)
Fosinopril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)
Fosinopril (Compound) upregulates SYNGR3 (Gene) and SYNGR3 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Fosinopril (Compound) upregulates SYNGR3 (Gene) and SYNGR3 (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Fosinopril (Compound) resembles Cilazapril (Compound) and Cilazapril (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)