DDInter1960 DDInter1427
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. Other forms of pentoxyverine citrate continue to be marketed.
Pentoxyverine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nalbuphine
Pentoxyverine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brexanolone
Pentoxyverine {u} may lead to a major life threatening interaction when taken with {v} Rasagiline
Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine
Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Brexanolone
Pentoxyverine may lead to a major life threatening interaction when taken with Rasagiline