DDInter405 DDInter704
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) PNP
PNP {u} (Gene) is upregulated by {v} (Compound) Everolimus
Clofarabine {u} (Compound) downregulates {v} (Gene) HMG20B
HMG20B {u} (Gene) is upregulated by {v} (Compound) Everolimus
Clofarabine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Everolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Clofarabine {u} (Compound) causes {v} (Side Effect) Pericardial effusion
Pericardial effusion {u} (Side Effect) is caused by {v} (Compound) Everolimus
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) CCNL1
CCNL1 {u} (Gene) regulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) KCTD5
KCTD5 {u} (Gene) is regulated by {v} (Gene) GADD45B
GADD45B {u} (Gene) is upregulated by {v} (Compound) Everolimus
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Clofarabine (Compound) upregulates PNP (Gene) and PNP (Gene) is upregulated by Everolimus (Compound)
Clofarabine (Compound) downregulates HMG20B (Gene) and HMG20B (Gene) is upregulated by Everolimus (Compound)
Clofarabine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Everolimus (Compound)
Clofarabine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Everolimus (Compound)
Clofarabine (Compound) causes Pericardial effusion (Side Effect) and Pericardial effusion (Side Effect) is caused by Everolimus (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Clofarabine (Compound) upregulates PNP (Gene) and PNP (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Clofarabine (Compound) upregulates CCNL1 (Gene) and CCNL1 (Gene) regulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Everolimus (Compound)
Clofarabine (Compound) upregulates KCTD5 (Gene) and KCTD5 (Gene) is regulated by GADD45B (Gene) and GADD45B (Gene) is upregulated by Everolimus (Compound)