DDInter458 DDInter1874
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.
Cyclosporine {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is bound by {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TYMS
TYMS {u} (Gene) is bound by {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Montelukast
Montelukast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Cyclosporine {u} (Compound) downregulates {v} (Gene) DHFR
DHFR {u} (Gene) is bound by {v} (Compound) Trimetrexate
Trimetrexate {u} (Compound) resembles {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Montelukast
Montelukast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Papaverine
Papaverine {u} (Compound) resembles {v} (Compound) Trimethoprim
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tinnitus
Tinnitus {u} (Side Effect) is caused by {v} (Compound) Dapsone
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Cyclosporine (Compound) downregulates TYMS (Gene) and TYMS (Gene) is bound by Trimethoprim (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Trimethoprim (Compound)
Cyclosporine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Trimethoprim (Compound)
Cyclosporine (Compound) downregulates TYMS (Gene) and TYMS (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Trimethoprim (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TYMS (Gene) and TYMS (Gene) is bound by Trimethoprim (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Montelukast (Compound) and Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim
Cyclosporine (Compound) downregulates DHFR (Gene) and DHFR (Gene) is bound by Trimetrexate (Compound) and Trimetrexate (Compound) resembles Trimethoprim (Compound)
Cyclosporine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Montelukast (Compound) and Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim
Cyclosporine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Papaverine (Compound) and Papaverine (Compound) resembles Trimethoprim (Compound)
Cyclosporine (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Dapsone (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim