DDInter535 DDInter118
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism of alpha-adrenergic and 5-HT2A receptors.[L45859,A4393] Aripiprazole was given FDA approval on November 15, 2002.
Diazoxide {u} (Compound) causes {v} (Side Effect) Glycosuria
Glycosuria {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Diazoxide {u} (Compound) causes {v} (Side Effect) Glycosuria
Glycosuria {u} (Side Effect) is caused by {v} (Compound) Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Aripiprazole
Diazoxide {u} (Compound) causes {v} (Side Effect) Lacrimation increased
Lacrimation increased {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aripiprazole
Diazoxide {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Diazoxide {u} (Compound) causes {v} (Side Effect) Albuminuria
Albuminuria {u} (Side Effect) is caused by {v} (Compound) Ziprasidone
Ziprasidone {u} (Compound) resembles {v} (Compound) Aripiprazole
Diazoxide {u} (Compound) causes {v} (Side Effect) Haemoglobin decreased
Haemoglobin decreased {u} (Side Effect) is caused by {v} (Compound) Lapatinib
Lapatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aripiprazole
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Aripiprazole
Diazoxide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is downregulated by {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Aripiprazole
Diazoxide (Compound) causes Glycosuria (Side Effect) and Glycosuria (Side Effect) is caused by Aripiprazole (Compound)
Diazoxide (Compound) causes Glycosuria (Side Effect) and Glycosuria (Side Effect) is caused by Perphenazine (Compound) and Perphenazine (Compound) resembles Aripiprazole (Compound)
Diazoxide (Compound) causes Lacrimation increased (Side Effect) and Lacrimation increased (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Aripiprazole
Diazoxide (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Diazoxide (Compound) causes Albuminuria (Side Effect) and Albuminuria (Side Effect) is caused by Ziprasidone (Compound) and Ziprasidone (Compound) resembles Aripiprazole (Compound)
Diazoxide (Compound) causes Haemoglobin decreased (Side Effect) and Haemoglobin decreased (Side Effect) is caused by Lapatinib (Compound) and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Aripiprazole (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates PCNA (Gene) and PCNA (Gene) is downregulated by Aripiprazole (Compound)
Diazoxide (Compound) binds CA2 (Gene) and CA2 (Gene) is downregulated by schizophrenia (Disease) and schizophrenia (Disease) is palliated by Aripiprazole (Compound)