DDInter43 DDInter1376
A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Alfentanil {u} (Compound) resembles {v} (Compound) Remifentanil
Alfentanil {u} (Compound) binds {v} (Gene) CYP3A7
Alfentanil {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Alfentanil {u} (Compound) causes {v} (Side Effect) Tachycardia
Alfentanil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Alfentanil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Apalutamide
Alfentanil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Alfentanil {u} may lead to a major life threatening interaction when taken with {v} Clarithromycin
Alfentanil {u} may lead to a major life threatening interaction when taken with {v} Fenfluramine
Alfentanil (Compound) resembles Remifentanil (Compound)
Alfentanil (Compound) binds CYP3A7 (Gene)
Alfentanil (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Alfentanil (Compound) causes Tachycardia (Side Effect)
Alfentanil may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Alfentanil may lead to a major life threatening interaction when taken with Clarithromycin
Alfentanil may lead to a major life threatening interaction when taken with Fenfluramine