DDInter1158 DDInter241
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239]
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Bromfenac
Mesalazine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Bromfenac
Mesalazine {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Bromfenac
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Balsalazide
Balsalazide {u} (Compound) resembles {v} (Compound) Bromfenac
Mesalazine {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Balsalazide
Balsalazide {u} (Compound) resembles {v} (Compound) Bromfenac
Mesalazine {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Bromfenac
Mesalazine {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Mesalazine {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Suprofen
Suprofen {u} (Compound) resembles {v} (Compound) Bromfenac
Mesalazine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Balsalazide
Balsalazide {u} (Compound) resembles {v} (Compound) Bromfenac
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Bromfenac (Compound)
Mesalazine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Bromfenac (Compound)
Mesalazine (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Bromfenac (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Balsalazide (Compound) and Balsalazide (Compound) resembles Bromfenac (Compound)
Mesalazine (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Balsalazide (Compound) and Balsalazide (Compound) resembles Bromfenac (Compound)
Mesalazine (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Bromfenac (Compound)
Mesalazine (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac
Mesalazine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Suprofen (Compound) and Suprofen (Compound) resembles Bromfenac (Compound)
Mesalazine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Balsalazide (Compound) and Balsalazide (Compound) resembles Bromfenac (Compound)