DDInter716 DDInter1652
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Felodipine {u} (Compound) resembles {v} (Compound) Amlodipine
Felodipine {u} (Compound) resembles {v} (Compound) Isradipine
Felodipine {u} (Compound) treats {v} (Disease) hypertension
Felodipine {u} (Compound) binds {v} (Gene) CACNA1S
Felodipine {u} (Compound) upregulates {v} (Gene) CGRRF1
Felodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Felodipine {u} (Compound) downregulates {v} (Gene) GJA1
Felodipine {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Felodipine (Compound) resembles Amlodipine (Compound)
Felodipine (Compound) resembles Isradipine (Compound)
Felodipine (Compound) treats hypertension (Disease)
Felodipine (Compound) binds CACNA1S (Gene)
Felodipine (Compound) upregulates CGRRF1 (Gene)
Felodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Felodipine (Compound) downregulates GJA1 (Gene)
Felodipine (Compound) causes Sexual dysfunction (Side Effect)
Felodipine may cause a minor interaction that can limit clinical effects when taken with Theophylline
Felodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor