DDInter704 DDInter1627
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Everolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Everolimus {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Everolimus {u} (Compound) binds {v} (Gene) MTOR
MTOR {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Everolimus {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Everolimus {u} (Compound) binds {v} (Gene) MTOR
MTOR {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Everolimus {u} (Compound) downregulates {v} (Gene) STAMBP
STAMBP {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Everolimus {u} (Compound) downregulates {v} (Gene) STAMBP
STAMBP {u} (Gene) is regulated by {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Everolimus {u} (Compound) downregulates {v} (Gene) ADSL
ADSL {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Everolimus {u} (Compound) upregulates {v} (Gene) CASP3
CASP3 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Everolimus {u} (Compound) upregulates {v} (Gene) RGS2
RGS2 {u} (Gene) interacts with {v} (Gene) SCN5A
SCN5A {u} (Gene) is bound by {v} (Compound) Rufinamide
Everolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Everolimus (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Everolimus (Compound) binds MTOR (Gene) and MTOR (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Everolimus (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Everolimus (Compound) binds MTOR (Gene) and MTOR (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Everolimus (Compound) downregulates STAMBP (Gene) and STAMBP (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Everolimus (Compound) downregulates STAMBP (Gene) and STAMBP (Gene) is regulated by CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Everolimus (Compound) downregulates ADSL (Gene) and ADSL (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Everolimus (Compound) upregulates CASP3 (Gene) and CASP3 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Everolimus (Compound) upregulates RGS2 (Gene) and RGS2 (Gene) interacts with SCN5A (Gene) and SCN5A (Gene) is bound by Rufinamide (Compound)