DDInter1554 DDInter1376
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Quinapril {u} (Compound) resembles {v} (Compound) Trandolapril
Quinapril {u} (Compound) resembles {v} (Compound) Benazepril
Quinapril {u} (Compound) treats {v} (Disease) hypertension
Quinapril {u} (Compound) binds {v} (Gene) SLC15A2
Quinapril {u} (Compound) causes {v} (Side Effect) Photosensitivity reaction
Quinapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium bicarbonate
Quinapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Erythropoietin
Quinapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dalteparin
Quinapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urokinase
Quinapril {u} may lead to a major life threatening interaction when taken with {v} Potassium Iodide
Quinapril (Compound) resembles Trandolapril (Compound)
Quinapril (Compound) resembles Benazepril (Compound)
Quinapril (Compound) treats hypertension (Disease)
Quinapril (Compound) binds SLC15A2 (Gene)
Quinapril (Compound) causes Photosensitivity reaction (Side Effect)
Quinapril may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Quinapril may cause a minor interaction that can limit clinical effects when taken with Erythropoietin
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Urokinase
Quinapril may lead to a major life threatening interaction when taken with Potassium Iodide