DDInter1091 DDInter782
Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form of netupitant [FDA label]. Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting as major side effects. Considered one of the most distressing side effects of chemotherapy, nausea and vomiting has an immense impact on the quality of life of patients receiving certain antineoplastic therapies .
Loratadine {u} (Compound) resembles {v} (Compound) Desloratadine
Loratadine {u} (Compound) resembles {v} (Compound) Ketotifen
Loratadine {u} (Compound) treats {v} (Disease) asthma
Loratadine {u} (Compound) binds {v} (Gene) CYP3A4
Loratadine {u} (Compound) upregulates {v} (Gene) DDIT4
Loratadine {u} (Compound) downregulates {v} (Gene) TUBB6
Loratadine {u} (Compound) causes {v} (Side Effect) Syncope
Loratadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Loratadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Loratadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Loratadine (Compound) resembles Desloratadine (Compound)
Loratadine (Compound) resembles Ketotifen (Compound)
Loratadine (Compound) treats asthma (Disease)
Loratadine (Compound) binds CYP3A4 (Gene)
Loratadine (Compound) upregulates DDIT4 (Gene)
Loratadine (Compound) downregulates TUBB6 (Gene)
Loratadine (Compound) causes Syncope (Side Effect)
Loratadine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Loratadine may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine