DDInter458 DDInter1492
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) downregulates {v} (Gene) KIF11
KIF11 {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) downregulates {v} (Gene) PAFAH1B3
PAFAH1B3 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) RABAC1
RABAC1 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) binds {v} (Gene) PPIF
PPIF {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) causes {v} (Side Effect) Migraine
Migraine {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ponatinib
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ponatinib
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Cyclosporine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Ponatinib (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ponatinib (Compound)
Cyclosporine (Compound) downregulates KIF11 (Gene) and KIF11 (Gene) is upregulated by Ponatinib (Compound)
Cyclosporine (Compound) downregulates PAFAH1B3 (Gene) and PAFAH1B3 (Gene) is downregulated by Ponatinib (Compound)
Cyclosporine (Compound) upregulates RABAC1 (Gene) and RABAC1 (Gene) is downregulated by Ponatinib (Compound)
Cyclosporine (Compound) binds PPIF (Gene) and PPIF (Gene) is downregulated by Ponatinib (Compound)
Cyclosporine (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Ponatinib (Compound)
Cyclosporine (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ponatinib
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Ponatinib (Compound)