DDInter150 DDInter1835
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) is upregulated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) downregulates {v} (Gene) SUZ12
SUZ12 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) upregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) causes {v} (Side Effect) Haemoglobin
Haemoglobin {u} (Side Effect) is caused by {v} (Compound) Topotecan
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Topotecan
Azathioprine {u} (Compound) upregulates {v} (Gene) ADAT1
ADAT1 {u} (Gene) is regulated by {v} (Gene) SOX2
SOX2 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) downregulates {v} (Gene) SUZ12
SUZ12 {u} (Gene) is associated with {v} (Disease) peripheral nervous system neoplasm
peripheral nervous system neoplasm {u} (Disease) is treated by {v} (Compound) Topotecan
Azathioprine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) is regulated by {v} (Gene) SPR
SPR {u} (Gene) is upregulated by {v} (Compound) Topotecan
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Topotecan (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) is upregulated by Topotecan (Compound)
Azathioprine (Compound) downregulates SUZ12 (Gene) and SUZ12 (Gene) is downregulated by Topotecan (Compound)
Azathioprine (Compound) upregulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Topotecan (Compound)
Azathioprine (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Topotecan (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Topotecan (Compound)
Azathioprine (Compound) upregulates ADAT1 (Gene) and ADAT1 (Gene) is regulated by SOX2 (Gene) and SOX2 (Gene) is upregulated by Topotecan (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Topotecan (Compound)
Azathioprine (Compound) downregulates SUZ12 (Gene) and SUZ12 (Gene) is associated with peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is treated by Topotecan (Compound)
Azathioprine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) is regulated by SPR (Gene) and SPR (Gene) is upregulated by Topotecan (Compound)