DDInter917 DDInter1853
A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Indinavir {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Tretinoin
Indinavir {u} (Compound) upregulates {v} (Gene) EPHB2
EPHB2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Indinavir {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Indinavir {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Indinavir {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Indinavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Indinavir {u} (Compound) upregulates {v} (Gene) EPHB2
EPHB2 {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Indinavir {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Indinavir {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Indinavir {u} (Compound) resembles {v} (Compound) Alvimopan
Alvimopan {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Indinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Tretinoin (Compound)
Indinavir (Compound) upregulates EPHB2 (Gene) and EPHB2 (Gene) is upregulated by Tretinoin (Compound)
Indinavir (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Tretinoin (Compound)
Indinavir (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Tretinoin (Compound)
Indinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tretinoin (Compound)
Indinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Indinavir (Compound) upregulates EPHB2 (Gene) and EPHB2 (Gene) is upregulated by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Indinavir (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Indinavir (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Indinavir (Compound) resembles Alvimopan (Compound) and Alvimopan (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Tretinoin (Compound)