DDInter1158 DDInter1451
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter&#39;s syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Phenylbutazone
Mesalazine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Phenylbutazone
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutazone
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Oxaprozin
Oxaprozin {u} (Compound) resembles {v} (Compound) Phenylbutazone
Mesalazine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutazone
Mesalazine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Phenylbutazone
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} (Compound) resembles {v} (Compound) Phenylbutazone
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) interacts with {v} (Gene) PTGIS
PTGIS {u} (Gene) is bound by {v} (Compound) Phenylbutazone
Mesalazine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutazone
Mesalazine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Phenylbutazone
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Phenylbutazone (Compound)
Mesalazine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Phenylbutazone (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Oxaprozin (Compound) and Oxaprozin (Compound) resembles Phenylbutazone (Compound)
Mesalazine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is upregulated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone
Mesalazine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Methadone (Compound) and Methadone (Compound) resembles Phenylbutazone (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) resembles Phenylbutazone (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) interacts with PTGIS (Gene) and PTGIS (Gene) is bound by Phenylbutazone (Compound)
Mesalazine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone
Mesalazine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Phenylbutazone (Compound)