DDInter998 DDInter1763
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) downregulates {v} (Gene) TFDP1
TFDP1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) upregulates {v} (Gene) CDC42BPA
CDC42BPA {u} (Gene) is regulated by {v} (Gene) ADGRG1
ADGRG1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) interacts with {v} (Gene) SETDB1
SETDB1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) upregulates {v} (Gene) MUTYH
MUTYH {u} (Gene) interacts with {v} (Gene) RPA1
RPA1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Ivermectin {u} (Compound) upregulates {v} (Gene) SARS
SARS {u} (Gene) regulates {v} (Gene) TF
TF {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Ivermectin (Compound) upregulates MYC (Gene) and MYC (Gene) is upregulated by Temsirolimus (Compound)
Ivermectin (Compound) downregulates TFDP1 (Gene) and TFDP1 (Gene) is downregulated by Temsirolimus (Compound)
Ivermectin (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Temsirolimus (Compound)
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Ivermectin (Compound) upregulates MYC (Gene) and MYC (Gene) is upregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Ivermectin (Compound) upregulates CDC42BPA (Gene) and CDC42BPA (Gene) is regulated by ADGRG1 (Gene) and ADGRG1 (Gene) is upregulated by Temsirolimus (Compound)
Ivermectin (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) interacts with SETDB1 (Gene) and SETDB1 (Gene) is upregulated by Temsirolimus (Compound)
Ivermectin (Compound) upregulates MUTYH (Gene) and MUTYH (Gene) interacts with RPA1 (Gene) and RPA1 (Gene) is downregulated by Temsirolimus (Compound)
Ivermectin (Compound) upregulates SARS (Gene) and SARS (Gene) regulates TF (Gene) and TF (Gene) is upregulated by Temsirolimus (Compound)