DDInter896 DDInter1544
Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553] Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Hyoscyamine {u} (Compound) resembles {v} (Compound) Dolasetron
Hyoscyamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Hyoscyamine {u} (Compound) resembles {v} (Compound) Cocaine
Hyoscyamine {u} (Compound) treats {v} (Disease) pancreatitis
Hyoscyamine {u} (Compound) binds {v} (Gene) CHRM4
Hyoscyamine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Hyoscyamine {u} (Compound) downregulates {v} (Gene) DLD
Hyoscyamine {u} (Compound) causes {v} (Side Effect) Angle closure glaucoma
Hyoscyamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Hyoscyamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Hyoscyamine (Compound) resembles Dolasetron (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Hyoscyamine (Compound) resembles Cocaine (Compound)
Hyoscyamine (Compound) treats pancreatitis (Disease)
Hyoscyamine (Compound) binds CHRM4 (Gene)
Hyoscyamine (Compound) palliates Parkinson's disease (Disease)
Hyoscyamine (Compound) downregulates DLD (Gene)
Hyoscyamine (Compound) causes Angle closure glaucoma (Side Effect)
Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Digoxin