DDInter1814 DDInter255
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Tioguanine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Tioguanine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Tioguanine {u} (Compound) binds {v} (Gene) IMPDH2
IMPDH2 {u} (Gene) is regulated by {v} (Gene) TLE1
TLE1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) binds {v} (Gene) ABCC4
ABCC4 {u} (Gene) covaries with {v} (Gene) TSPAN4
TSPAN4 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) binds {v} (Gene) IMPDH2
IMPDH2 {u} (Gene) is regulated by {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) binds {v} (Gene) IMPDH1
IMPDH1 {u} (Gene) interacts with {v} (Gene) GMNN
GMNN {u} (Gene) is downregulated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) binds {v} (Gene) IMPDH2
IMPDH2 {u} (Gene) regulates {v} (Gene) SPR
SPR {u} (Gene) is downregulated by {v} (Compound) Busulfan
Tioguanine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) interacts with {v} (Gene) FANCA
FANCA {u} (Gene) is upregulated by {v} (Compound) Busulfan
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Tioguanine (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Busulfan (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Tioguanine (Compound) binds IMPDH2 (Gene) and IMPDH2 (Gene) is regulated by TLE1 (Gene) and TLE1 (Gene) is downregulated by Busulfan (Compound)
Tioguanine (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) covaries with TSPAN4 (Gene) and TSPAN4 (Gene) is downregulated by Busulfan (Compound)
Tioguanine (Compound) binds IMPDH2 (Gene) and IMPDH2 (Gene) is regulated by PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)
Tioguanine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Tioguanine (Compound) binds IMPDH1 (Gene) and IMPDH1 (Gene) interacts with GMNN (Gene) and GMNN (Gene) is downregulated by Busulfan (Compound)
Tioguanine (Compound) binds IMPDH2 (Gene) and IMPDH2 (Gene) regulates SPR (Gene) and SPR (Gene) is downregulated by Busulfan (Compound)
Tioguanine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) interacts with FANCA (Gene) and FANCA (Gene) is upregulated by Busulfan (Compound)