DDInter458 DDInter1312
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol]. Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency, and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.[L9527,L10301,L10304,L10307] First derived in 1951 in Mexico City, norethisterone was originally intended for use as a remedy for irregular menstruation and endometriosis, and was not marketed for use as an oral contraceptive until 1962.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) PGM3
PGM3 {u} (Gene) is upregulated by {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) downregulates {v} (Gene) DNM1L
DNM1L {u} (Gene) is upregulated by {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) is downregulated by {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) TP53
TP53 {u} (Gene) is downregulated by {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Depression
Depression {u} (Side Effect) is caused by {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Gestodene
Gestodene {u} (Compound) resembles {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) upregulates {v} (Gene) PGM3
PGM3 {u} (Gene) is upregulated by {v} (Compound) Danazol
Danazol {u} (Compound) resembles {v} (Compound) Norethisterone
Cyclosporine {u} (Compound) downregulates {v} (Gene) DNM1L
DNM1L {u} (Gene) is downregulated by {v} (Compound) Ethynodiol
Ethynodiol {u} (Compound) resembles {v} (Compound) Norethisterone
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Norethisterone (Compound)
Cyclosporine (Compound) upregulates PGM3 (Gene) and PGM3 (Gene) is upregulated by Norethisterone (Compound)
Cyclosporine (Compound) downregulates DNM1L (Gene) and DNM1L (Gene) is upregulated by Norethisterone (Compound)
Cyclosporine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) is downregulated by Norethisterone (Compound)
Cyclosporine (Compound) upregulates TP53 (Gene) and TP53 (Gene) is downregulated by Norethisterone (Compound)
Cyclosporine (Compound) causes Depression (Side Effect) and Depression (Side Effect) is caused by Norethisterone (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Norethisterone (Compound)
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Gestodene (Compound) and Gestodene (Compound) resembles Norethisterone (Compound)
Cyclosporine (Compound) upregulates PGM3 (Gene) and PGM3 (Gene) is upregulated by Danazol (Compound) and Danazol (Compound) resembles Norethisterone (Compound)
Cyclosporine (Compound) downregulates DNM1L (Gene) and DNM1L (Gene) is downregulated by Ethynodiol (Compound) and Ethynodiol (Compound) resembles Norethisterone (Compound)