DDInter458 DDInter743
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) MELK
MELK {u} (Gene) is upregulated by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inhibitors
Cytochrome P450 3A4 Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) upregulates {v} (Gene) WFS1
WFS1 {u} (Gene) is downregulated by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) DNTTIP2
DNTTIP2 {u} (Gene) is downregulated by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Rigors
Rigors {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Clarithromycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) CASC3
CASC3 {u} (Gene) is downregulated by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) MELK
MELK {u} (Gene) regulates {v} (Gene) CASC3
CASC3 {u} (Gene) is downregulated by {v} (Compound) Fluconazole
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inhibitors
Cytochrome P450 3A4 Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Clarithromycin
Clarithromycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Fluconazole (Compound)
Cyclosporine (Compound) downregulates MELK (Gene) and MELK (Gene) is upregulated by Fluconazole (Compound)
Cyclosporine (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Fluconazole (Compound)
Cyclosporine (Compound) upregulates WFS1 (Gene) and WFS1 (Gene) is downregulated by Fluconazole (Compound)
Cyclosporine (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) is downregulated by Fluconazole (Compound)
Cyclosporine (Compound) causes Rigors (Side Effect) and Rigors (Side Effect) is caused by Fluconazole (Compound)
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Clarithromycin (Compound) and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates CASC3 (Gene) and CASC3 (Gene) is downregulated by Fluconazole (Compound)
Cyclosporine (Compound) downregulates MELK (Gene) and MELK (Gene) regulates CASC3 (Gene) and CASC3 (Gene) is downregulated by Fluconazole (Compound)
Cyclosporine (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Clarithromycin (Compound) and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Fluconazole