DDInter111 DDInter119
Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and central nervous system inflammation.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Apremilast {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Apremilast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betrixaban
Apremilast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rifabutin
Apremilast {u} may lead to a major life threatening interaction when taken with {v} Fosphenytoin
Apremilast {u} may lead to a major life threatening interaction when taken with {v} Enzalutamide
Apremilast may cause a minor interaction that can limit clinical effects when taken with Modafinil
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Apremilast may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin
Apremilast may lead to a major life threatening interaction when taken with Fosphenytoin
Apremilast may lead to a major life threatening interaction when taken with Enzalutamide