DDInter458 DDInter672
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class. Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) downregulates {v} (Gene) BACE2
BACE2 {u} (Gene) is downregulated by {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is downregulated by {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dysmenorrhoea
Dysmenorrhoea {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) downregulates {v} (Gene) BACE2
BACE2 {u} (Gene) is downregulated by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is downregulated by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dysmenorrhoea
Dysmenorrhoea {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is palliated by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Escitalopram
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Miconazole
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Escitalopram
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Cyclosporine (Compound) downregulates BACE2 (Gene) and BACE2 (Gene) is downregulated by Escitalopram (Compound)
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Escitalopram (Compound)
Cyclosporine (Compound) causes Dysmenorrhoea (Side Effect) and Dysmenorrhoea (Side Effect) is caused by Escitalopram (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Cyclosporine (Compound) downregulates BACE2 (Gene) and BACE2 (Gene) is downregulated by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Cyclosporine (Compound) causes Dysmenorrhoea (Side Effect) and Dysmenorrhoea (Side Effect) is caused by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is palliated by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound) and Miconazole may cause a minor interaction that can limit clinical effects when taken with Escitalopram