DDInter1627 DDInter1763
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Rufinamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) binds {v} (Gene) CES1
CES1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) binds {v} (Gene) CES1
CES1 {u} (Gene) is regulated by {v} (Gene) MTOR
MTOR {u} (Gene) is bound by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) MTOR
MTOR {u} (Gene) is bound by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) binds {v} (Gene) CES1
CES1 {u} (Gene) is regulated by {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) binds {v} (Gene) SCN8A
SCN8A {u} (Gene) interacts with {v} (Gene) PHB
PHB {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Rufinamide {u} (Compound) binds {v} (Gene) SCN1A
SCN1A {u} (Gene) interacts with {v} (Gene) UBE2M
UBE2M {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Rufinamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Rufinamide (Compound) binds CES1 (Gene) and CES1 (Gene) is upregulated by Temsirolimus (Compound)
Rufinamide (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Temsirolimus (Compound)
Rufinamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Rufinamide (Compound) binds CES1 (Gene) and CES1 (Gene) is regulated by MTOR (Gene) and MTOR (Gene) is bound by Temsirolimus (Compound)
Rufinamide (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Rufinamide (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with MTOR (Gene) and MTOR (Gene) is bound by Temsirolimus (Compound)
Rufinamide (Compound) binds CES1 (Gene) and CES1 (Gene) is regulated by KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Temsirolimus (Compound)
Rufinamide (Compound) binds SCN8A (Gene) and SCN8A (Gene) interacts with PHB (Gene) and PHB (Gene) is downregulated by Temsirolimus (Compound)
Rufinamide (Compound) binds SCN1A (Gene) and SCN1A (Gene) interacts with UBE2M (Gene) and UBE2M (Gene) is downregulated by Temsirolimus (Compound)