DDInter758 DDInter1123
Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.
Fluoxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Fluoxetine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Fluoxetine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) resembles {v} (Compound) Mannitol
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Clarithromycin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Fluoxetine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Clarithromycin {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Fluoxetine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Sorafenib {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Sorafenib {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Mannitol
Fluoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Liothyronine
Liothyronine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Fluoxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Fluoxetine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Fluoxetine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) resembles Mannitol (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Fluoxetine may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Fluoxetine may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Mannitol (Compound)
Fluoxetine may cause a minor interaction that can limit clinical effects when taken with Liothyronine and Liothyronine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)