DDInter263 DDInter534
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans. Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection. The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999. According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 . Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect . This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy .
Caffeine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Diazepam
Caffeine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diazepam
Caffeine {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Diazepam
Caffeine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Caffeine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Caffeine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Caffeine {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Diazepam
Caffeine {u} (Compound) causes {v} (Side Effect) Acidosis
Acidosis {u} (Side Effect) is caused by {v} (Compound) Lorazepam
Lorazepam {u} (Compound) resembles {v} (Compound) Diazepam
Caffeine {u} (Compound) resembles {v} (Compound) Oxtriphylline
Oxtriphylline {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Diazepam
Caffeine {u} (Compound) resembles {v} (Compound) Oxtriphylline
Oxtriphylline {u} (Compound) causes {v} (Side Effect) Injection site reaction
Injection site reaction {u} (Side Effect) is caused by {v} (Compound) Diazepam
Caffeine may cause a minor interaction that can limit clinical effects when taken with Clozapine and Clozapine (Compound) resembles Diazepam (Compound)
Caffeine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diazepam (Compound)
Caffeine (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Diazepam (Compound)
Caffeine may cause a minor interaction that can limit clinical effects when taken with Clozapine and Clozapine (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Caffeine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quazepam (Compound) and Quazepam (Compound) resembles Diazepam (Compound)
Caffeine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Caffeine (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Diazepam (Compound)
Caffeine (Compound) causes Acidosis (Side Effect) and Acidosis (Side Effect) is caused by Lorazepam (Compound) and Lorazepam (Compound) resembles Diazepam (Compound)
Caffeine (Compound) resembles Oxtriphylline (Compound) and Oxtriphylline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Diazepam (Compound)
Caffeine (Compound) resembles Oxtriphylline (Compound) and Oxtriphylline (Compound) causes Injection site reaction (Side Effect) and Injection site reaction (Side Effect) is caused by Diazepam (Compound)