DDInter1158 DDInter1478
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Piroxicam
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Piroxicam
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Meloxicam
Meloxicam {u} (Compound) resembles {v} (Compound) Piroxicam
Mesalazine {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Stevens-Johnson syndrome {u} (Side Effect) is caused by {v} (Compound) Meloxicam
Meloxicam {u} (Compound) resembles {v} (Compound) Piroxicam
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meloxicam
Meloxicam {u} (Compound) resembles {v} (Compound) Piroxicam
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Piroxicam
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Piroxicam
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Desmopressin
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Piroxicam
Mesalazine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Famotidine
Famotidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Piroxicam
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Piroxicam
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Piroxicam (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Meloxicam (Compound) and Meloxicam (Compound) resembles Piroxicam (Compound)
Mesalazine (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Meloxicam (Compound) and Meloxicam (Compound) resembles Piroxicam (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) resembles Piroxicam (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Piroxicam (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Piroxicam (Compound)
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Desmopressin (Compound) and Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam
Mesalazine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound) and Famotidine may cause a minor interaction that can limit clinical effects when taken with Piroxicam
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam