DDInter890 DDInter1180
Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound. Even though hydromorphone does not present a 6-hydroxyl group, it is categorized under the family of phenanthrenes and it is considered a chemical under the schedule II (medical purposes with high addiction potential). The first reported approved product containing hydromorphone in the form of hydromorphone hydrochloride was developed by Fresenius Kabi USA and FDA approved in 1984.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Hydromorphone {u} (Compound) resembles {v} (Compound) Ethylmorphine
Hydromorphone {u} (Compound) resembles {v} (Compound) Oxycodone
Hydromorphone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Hydromorphone {u} (Compound) binds {v} (Gene) CYP2D6
Hydromorphone {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Hydromorphone {u} (Compound) causes {v} (Side Effect) Syncope
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Hydromorphone {u} may lead to a major life threatening interaction when taken with {v} Alvimopan
Hydromorphone {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxone
Hydromorphone (Compound) resembles Ethylmorphine (Compound)
Hydromorphone (Compound) resembles Oxycodone (Compound)
Hydromorphone may lead to a major life threatening interaction when taken with Morphine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Hydromorphone (Compound) binds CYP2D6 (Gene)
Hydromorphone (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Hydromorphone (Compound) causes Syncope (Side Effect)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Trospium
Hydromorphone may lead to a major life threatening interaction when taken with Alvimopan
Hydromorphone (Compound) resembles Naloxone (Compound) and Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Naloxone