DDInter89 DDInter351
Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.[L43942,L44022]
Ampicillin {u} (Compound) upregulates {v} (Gene) APOA2
APOA2 {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ampicillin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Chloramphenicol
Ampicillin {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Ampicillin {u} (Compound) resembles {v} (Compound) Piperacillin
Piperacillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Ampicillin {u} (Compound) resembles {v} (Compound) Cefradine
Cefradine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Ampicillin {u} (Compound) resembles {v} (Compound) Benzylpenicillin
Benzylpenicillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Ampicillin {u} (Compound) upregulates {v} (Gene) APOA2
APOA2 {u} (Gene) is regulated by {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ampicillin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Ampicillin {u} (Compound) downregulates {v} (Gene) KRT7
KRT7 {u} (Gene) is downregulated by {v} (Compound) Altretamine
Altretamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Ampicillin {u} (Compound) downregulates {v} (Gene) PNMA2
PNMA2 {u} (Gene) is downregulated by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Ampicillin (Compound) upregulates APOA2 (Gene) and APOA2 (Gene) is upregulated by Chloramphenicol (Compound)
Ampicillin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Chloramphenicol (Compound)
Ampicillin (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Chloramphenicol (Compound)
Ampicillin (Compound) resembles Piperacillin (Compound) and Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Ampicillin (Compound) resembles Cefradine (Compound) and Cefradine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Ampicillin (Compound) resembles Benzylpenicillin (Compound) and Benzylpenicillin may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Ampicillin (Compound) upregulates APOA2 (Gene) and APOA2 (Gene) is regulated by MOK (Gene) and MOK (Gene) is upregulated by Chloramphenicol (Compound)
Ampicillin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by MOK (Gene) and MOK (Gene) is upregulated by Chloramphenicol (Compound)
Ampicillin (Compound) downregulates KRT7 (Gene) and KRT7 (Gene) is downregulated by Altretamine (Compound) and Altretamine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Ampicillin (Compound) downregulates PNMA2 (Gene) and PNMA2 (Gene) is downregulated by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol