DDInter576 DDInter1186
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered the market. Its use as an urinary tract antiseptic has also been investigated. Methylthioninium chloride (INN, or methylene blue, proposed trade name Rember) is an investigational drug being developed by the University of Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau protein aggregation. The drug is of potential interest for the treatment of patients with Alzheimer's disease.
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Ritodrine
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylene blue
Disulfiram {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Isoprenaline
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylene blue
Disulfiram {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Isoprenaline
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylene blue
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Phenobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylene blue
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Phenelzine
Phenelzine {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Disulfiram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Methylene blue
Disulfiram {u} (Compound) downregulates {v} (Gene) COG7
COG7 {u} (Gene) is upregulated by {v} (Compound) Pentobarbital
Pentobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylene blue
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Midodrine
Midodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylene blue
Disulfiram (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Ritodrine (Compound) and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Disulfiram (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Isoprenaline (Compound) and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Disulfiram (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Maprotiline (Compound) and Maprotiline may lead to a major life threatening interaction when taken with Methylene blue
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Isoprenaline (Compound) and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Disulfiram (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Methylene blue
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Phenobarbital (Compound) and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Phenelzine (Compound) and Phenelzine may lead to a major life threatening interaction when taken with Methylene blue
Disulfiram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Phentermine (Compound) and Phentermine may lead to a major life threatening interaction when taken with Methylene blue
Disulfiram (Compound) downregulates COG7 (Gene) and COG7 (Gene) is upregulated by Pentobarbital (Compound) and Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Midodrine (Compound) and Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue