DDInter1853 DDInter1084
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Tretinoin {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Cardiomyopathy
Cardiomyopathy {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Cardiomyopathy
Cardiomyopathy {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Idarubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Floxuridine
Floxuridine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Menstrual disorder
Menstrual disorder {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomefloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Menstrual disorder
Menstrual disorder {u} (Side Effect) is caused by {v} (Compound) Famotidine
Famotidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomefloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Tretinoin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Lomefloxacin (Compound)
Tretinoin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Tretinoin (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin (Compound) resembles Lomefloxacin (Compound)
Tretinoin (Compound) causes Cardiomyopathy (Side Effect) and Cardiomyopathy (Side Effect) is caused by Daunorubicin (Compound) and Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Tretinoin (Compound) causes Cardiomyopathy (Side Effect) and Cardiomyopathy (Side Effect) is caused by Idarubicin (Compound) and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Floxuridine (Compound) and Floxuridine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin
Tretinoin (Compound) causes Menstrual disorder (Side Effect) and Menstrual disorder (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin
Tretinoin (Compound) causes Menstrual disorder (Side Effect) and Menstrual disorder (Side Effect) is caused by Famotidine (Compound) and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin
Tretinoin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Ifosfamide (Compound) and Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin