DDInter603 DDInter1008
A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Droperidol {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Droperidol {u} (Compound) resembles {v} (Compound) Haloperidol
Haloperidol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Droperidol {u} (Compound) resembles {v} (Compound) Fluspirilene
Fluspirilene {u} (Compound) upregulates {v} (Gene) FDPS
FDPS {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) resembles {v} (Compound) Domperidone
Domperidone {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) covaries with {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) resembles {v} (Compound) Haloperidol
Haloperidol {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) resembles {v} (Compound) Domperidone
Domperidone {u} (Compound) causes {v} (Side Effect) Menopausal symptoms
Menopausal symptoms {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Droperidol {u} (Compound) resembles {v} (Compound) Fluspirilene
Fluspirilene {u} (Compound) upregulates {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Droperidol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Ketoconazole (Compound)
Droperidol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Droperidol (Compound) resembles Haloperidol (Compound) and Haloperidol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ketoconazole (Compound)
Droperidol (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Droperidol (Compound) resembles Fluspirilene (Compound) and Fluspirilene (Compound) upregulates FDPS (Gene) and FDPS (Gene) is upregulated by Ketoconazole (Compound)
Droperidol (Compound) resembles Domperidone (Compound) and Domperidone (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ketoconazole (Compound)
Droperidol (Compound) binds DRD2 (Gene) and DRD2 (Gene) covaries with DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Ketoconazole (Compound)
Droperidol (Compound) resembles Haloperidol (Compound) and Haloperidol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Ketoconazole (Compound)
Droperidol (Compound) resembles Domperidone (Compound) and Domperidone (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Ketoconazole (Compound)
Droperidol (Compound) resembles Fluspirilene (Compound) and Fluspirilene (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is bound by Ketoconazole (Compound) and CYP51A1 (Gene) is upregulated by Ketoconazole (Compound)