DDInter1294 DDInter809
Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Nilutamide {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Nilutamide {u} (Compound) resembles {v} (Compound) Enzalutamide
Enzalutamide {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Nilutamide {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Moxifloxacin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Nilutamide {u} (Compound) causes {v} (Side Effect) Alcohol intolerance
Alcohol intolerance {u} (Side Effect) is caused by {v} (Compound) Tolbutamide
Tolbutamide {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Nilutamide {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Nilutamide {u} (Compound) resembles {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Nilutamide {u} (Compound) causes {v} (Side Effect) Bone pain
Bone pain {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Nilutamide {u} (Compound) causes {v} (Side Effect) Alcohol intolerance
Alcohol intolerance {u} (Side Effect) is caused by {v} (Compound) Glimepiride
Glimepiride {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Nilutamide {u} (Compound) resembles {v} (Compound) Nitisinone
Nitisinone {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Nilutamide {u} (Compound) resembles {v} (Compound) Enzalutamide
Enzalutamide {u} may lead to a major life threatening interaction when taken with {v} Moxifloxacin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Nilutamide (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Gatifloxacin (Compound)
Nilutamide (Compound) resembles Enzalutamide (Compound) and Enzalutamide may lead to a major life threatening interaction when taken with Gatifloxacin
Nilutamide (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Moxifloxacin (Compound) and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Nilutamide (Compound) causes Alcohol intolerance (Side Effect) and Alcohol intolerance (Side Effect) is caused by Tolbutamide (Compound) and Tolbutamide may lead to a major life threatening interaction when taken with Gatifloxacin
Nilutamide (Compound) resembles Flutamide (Compound) and Flutamide (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is upregulated by Gatifloxacin (Compound)
Nilutamide (Compound) resembles Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Nilutamide (Compound) causes Bone pain (Side Effect) and Bone pain (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Gatifloxacin (Compound)
Nilutamide (Compound) causes Alcohol intolerance (Side Effect) and Alcohol intolerance (Side Effect) is caused by Glimepiride (Compound) and Glimepiride may lead to a major life threatening interaction when taken with Gatifloxacin
Nilutamide (Compound) resembles Nitisinone (Compound) and Nitisinone (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Gatifloxacin (Compound)
Nilutamide (Compound) resembles Enzalutamide (Compound) and Enzalutamide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)