DDInter603 DDInter1055
A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Droperidol {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Droperidol {u} (Compound) resembles {v} (Compound) Haloperidol
Haloperidol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Droperidol {u} (Compound) resembles {v} (Compound) Domperidone
Domperidone {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is associated with {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) resembles {v} (Compound) Haloperidol
Haloperidol {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) binds {v} (Gene) KCNH2
KCNH2 {u} (Gene) interacts with {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) resembles {v} (Compound) Domperidone
Domperidone {u} (Compound) downregulates {v} (Gene) PLEKHM1
PLEKHM1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Droperidol {u} (Compound) downregulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is regulated by {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Droperidol (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Levofloxacin (Compound)
Droperidol (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Droperidol (Compound) resembles Haloperidol (Compound) and Haloperidol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Droperidol (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Droperidol (Compound) resembles Domperidone (Compound) and Domperidone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Droperidol (Compound) binds HTR2A (Gene) and HTR2A (Gene) is associated with chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)
Droperidol (Compound) resembles Haloperidol (Compound) and Haloperidol (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Droperidol (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) interacts with PRKACA (Gene) and PRKACA (Gene) is downregulated by Levofloxacin (Compound)
Droperidol (Compound) resembles Domperidone (Compound) and Domperidone (Compound) downregulates PLEKHM1 (Gene) and PLEKHM1 (Gene) is downregulated by Levofloxacin (Compound)
Droperidol (Compound) downregulates CHIC2 (Gene) and CHIC2 (Gene) is regulated by TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)