DDInter1404 DDInter134
Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia cells have low levels of this enzyme and depend on exogenous sources. Therefore, the use of pegaspargase results in leukemic cell death.[A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic leukemia (ALL). However, using L-asparaginase derived from _Escherich
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Acarbose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Phenindione
Phenindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bicalutamide
Bicalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Simvastatin
Simvastatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Peginterferon alfa-2b
Peginterferon alfa-2b {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may lead to a major life threatening interaction when taken with {v} Teriflunomide
Teriflunomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Leflunomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Chenodeoxycholic acid and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Pegaspargase may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)