DDInter1166 DDInter1652
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of unique characteristics that have led to its increased use in the last two decades; in particular, methadone has a lower risk of neuropsychiatric toxicity compared to other opioids (due to a lack of active metabolites), minimal accumulation in renal failure, good bioavailability, low cost, and a long duration of action.[F4685,F4688,F4691,A185885,A185900,A185903] Due to its unique mechanism of action, methadone is particularly useful for the management of hard to treat pain syndromes
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Methadone {u} (Compound) resembles {v} (Compound) Diphenoxylate
Methadone {u} (Compound) resembles {v} (Compound) Ethopropazine
Methadone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Methadone {u} (Compound) binds {v} (Gene) CYP2B6
Methadone {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Methadone {u} (Compound) causes {v} (Side Effect) Cardiomyopathy
Methadone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ammonium chloride
Methadone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginterferon alfa-2a
Methadone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alpelisib
Methadone {u} may lead to a major life threatening interaction when taken with {v} Naltrexone
Methadone (Compound) resembles Diphenoxylate (Compound)
Methadone (Compound) resembles Ethopropazine (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Trospium
Methadone (Compound) binds CYP2B6 (Gene)
Methadone (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Methadone (Compound) causes Cardiomyopathy (Side Effect)
Methadone may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride
Methadone may cause a minor interaction that can limit clinical effects when taken with Peginterferon alfa-2a
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Methadone may lead to a major life threatening interaction when taken with Naltrexone