DDInter458 DDInter747
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position of the steroid structure - this fluorination is thought to be crucial to fludrocortisone's significant mineralocorticoid potency.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Testosterone
Testosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Vascular purpura
Vascular purpura {u} (Side Effect) is caused by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludrocortisone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Formoterol
Formoterol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludrocortisone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Testosterone
Testosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Oesophagitis
Oesophagitis {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Salmeterol
Salmeterol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludrocortisone
Cyclosporine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Fludrocortisone (Compound)
Cyclosporine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Cyclosporine (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Cyclosporine (Compound) causes Vascular purpura (Side Effect) and Vascular purpura (Side Effect) is caused by Ticlopidine (Compound) and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone
Cyclosporine (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Formoterol (Compound) and Formoterol may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Cyclosporine (Compound) causes Oesophagitis (Side Effect) and Oesophagitis (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Salmeterol (Compound) and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone