DDInter1678 DDInter1662
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Sirolimus {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Sirolimus {u} (Compound) downregulates {v} (Gene) ACLY
ACLY {u} (Gene) is upregulated by {v} (Compound) Sertraline
Sirolimus {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Sirolimus {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Sirolimus {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Sirolimus {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Sertraline
Sirolimus {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) regulates {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Sirolimus {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is regulated by {v} (Gene) ELOVL6
ELOVL6 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Sirolimus {u} (Compound) downregulates {v} (Gene) ACLY
ACLY {u} (Gene) regulates {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Sirolimus (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)
Sirolimus (Compound) downregulates ACLY (Gene) and ACLY (Gene) is upregulated by Sertraline (Compound)
Sirolimus (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sertraline (Compound)
Sirolimus (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Sirolimus (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by MAOB (Gene) and MAOB (Gene) is bound by Sertraline (Compound)
Sirolimus (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) regulates GNPDA1 (Gene) and GNPDA1 (Gene) is upregulated by Sertraline (Compound)
Sirolimus (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is regulated by ELOVL6 (Gene) and ELOVL6 (Gene) is upregulated by Sertraline (Compound)
Sirolimus (Compound) downregulates ACLY (Gene) and ACLY (Gene) regulates CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Sertraline (Compound)