DDInter427 DDInter358
Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.
Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of chloroprocaine is characterized by a short latency and duration, similar to the one observed with [lidocaine]. Chloroprocaine can be given as an injection, and is available in formulations with and without methylparaben as a preservative. Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks.[A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 for ocular surface anesthesia.
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} (Compound) binds {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Chloroprocaine
Cocaine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Chloroprocaine
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Oxybuprocaine
Oxybuprocaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} (Compound) binds {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} (Compound) binds {v} (Gene) SCN5A
SCN5A {u} (Gene) is bound by {v} (Compound) Cinchocaine
Cinchocaine {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Chloroprocaine
Cocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procaine
Procaine {u} (Compound) binds {v} (Gene) BCHE
BCHE {u} (Gene) is bound by {v} (Compound) Chloroprocaine
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) resembles Chloroprocaine (Compound)
Cocaine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Chloroprocaine (Compound)
Cocaine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Chloroprocaine (Compound)
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) resembles Oxybuprocaine (Compound) and Oxybuprocaine (Compound) resembles Chloroprocaine (Compound)
Cocaine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Procaine (Compound) and Procaine (Compound) resembles Chloroprocaine (Compound)
Cocaine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Procaine (Compound) and Procaine (Compound) resembles Chloroprocaine (Compound)
Cocaine (Compound) binds SCN5A (Gene) and SCN5A (Gene) is bound by Cinchocaine (Compound) and Cinchocaine (Compound) resembles Chloroprocaine (Compound)
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide (Compound) resembles Chloroprocaine (Compound)
Cocaine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Metoclopramide (Compound) and Metoclopramide (Compound) resembles Chloroprocaine (Compound)
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Procaine and Procaine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Chloroprocaine (Compound)