DDInter1868 DDInter875
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and 2. The combination product of trifluridine with tipiracil marketed as Lonsurf has been approved in Japan, the United States, and the European Union for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In the anticancer therapy, trifluridine acts as a thymidine-based nucleoside metabolic inhibitor that gets
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and self-assembled into VLPs.
Trifluridine {u} (Compound) resembles {v} (Compound) Telbivudine
Trifluridine {u} (Compound) resembles {v} (Compound) Pentostatin
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Trifluridine {u} (Compound) binds {v} (Gene) SLC22A6
Trifluridine {u} (Compound) upregulates {v} (Gene) CRIP1
Trifluridine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Trifluridine {u} (Compound) downregulates {v} (Gene) UBQLN2
Trifluridine {u} (Compound) causes {v} (Side Effect) Keratitis sicca
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegfilgrastim
Trifluridine {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Trifluridine (Compound) resembles Telbivudine (Compound)
Trifluridine (Compound) resembles Pentostatin (Compound)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Trifluridine (Compound) binds SLC22A6 (Gene)
Trifluridine (Compound) upregulates CRIP1 (Gene)
Trifluridine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Trifluridine (Compound) downregulates UBQLN2 (Gene)
Trifluridine (Compound) causes Keratitis sicca (Side Effect)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim
Trifluridine may lead to a major life threatening interaction when taken with Clozapine