DDInter458 DDInter1716
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Muscle contractions involuntary
Muscle contractions involuntary {u} (Side Effect) is caused by {v} (Compound) Succinylcholine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Muscle contractions involuntary
Muscle contractions involuntary {u} (Side Effect) is caused by {v} (Compound) Edrophonium
Edrophonium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Succinylcholine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Carbachol
Carbachol {u} (Compound) resembles {v} (Compound) Succinylcholine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Succinylcholine
Cyclosporine {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Carbachol
Carbachol {u} (Compound) resembles {v} (Compound) Succinylcholine
Cyclosporine {u} (Compound) upregulates {v} (Gene) DHRS7
DHRS7 {u} (Gene) is downregulated by {v} (Compound) Carbachol
Carbachol {u} (Compound) resembles {v} (Compound) Succinylcholine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Succinylcholine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CDK7
CDK7 {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Succinylcholine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Succinylcholine
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Succinylcholine
Cyclosporine (Compound) causes Muscle contractions involuntary (Side Effect) and Muscle contractions involuntary (Side Effect) is caused by Succinylcholine (Compound)
Cyclosporine (Compound) causes Muscle contractions involuntary (Side Effect) and Muscle contractions involuntary (Side Effect) is caused by Edrophonium (Compound) and Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Succinylcholine
Cyclosporine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Carbachol (Compound) and Carbachol (Compound) resembles Succinylcholine (Compound)
Cyclosporine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Succinylcholine
Cyclosporine (Compound) downregulates TYMS (Gene) and TYMS (Gene) is downregulated by Carbachol (Compound) and Carbachol (Compound) resembles Succinylcholine (Compound)
Cyclosporine (Compound) upregulates DHRS7 (Gene) and DHRS7 (Gene) is downregulated by Carbachol (Compound) and Carbachol (Compound) resembles Succinylcholine (Compound)
Cyclosporine (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Succinylcholine
Cyclosporine (Compound) upregulates CDK7 (Gene) and CDK7 (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Succinylcholine (Compound)
Cyclosporine (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Succinylcholine (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Succinylcholine