DDInter1834 DDInter1793
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Topiramate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sucralfate
Sucralfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Thiethylperazine
Topiramate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Sotalol
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Topiramate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Pregabalin
Pregabalin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Topiramate {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Tramadol
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Thiethylperazine
Topiramate {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Thiethylperazine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Nicardipine
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Pregabalin
Pregabalin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Fosphenytoin
Fosphenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Zonisamide
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Thiethylperazine
Topiramate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sucralfate (Compound) and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Topiramate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Topiramate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Pregabalin (Compound) and Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Topiramate (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Tramadol (Compound) and Tramadol may lead to a major life threatening interaction when taken with Thiethylperazine
Topiramate (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Thiethylperazine
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Pregabalin (Compound) and Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Fosphenytoin (Compound) and Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Zonisamide (Compound) and Zonisamide may lead to a major life threatening interaction when taken with Thiethylperazine