DDInter388 DDInter832
Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the inhibition of serotonin reuptake, and among all the SSRIs, citalopram appears to be the most selective toward serotonin reuptake inhibition.[A261316,A14720] Specifically, it has a very minimal effect on dopamine and norepinephrine transportation and virtually no affinity for muscarinic, histaminergic, or GABAergic receptors. Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 years or older.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Citalopram {u} (Compound) treats {v} (Disease) alcohol dependence
Citalopram {u} (Compound) binds {v} (Gene) HTR2C
Citalopram {u} (Compound) upregulates {v} (Gene) PLS1
Citalopram {u} (Compound) palliates {v} (Disease) panic disorder
Citalopram {u} (Compound) downregulates {v} (Gene) RNH1
Citalopram {u} (Compound) causes {v} (Side Effect) Allergy aggravated
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cobicistat
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Citalopram (Compound) resembles Escitalopram (Compound)
Citalopram (Compound) treats alcohol dependence (Disease)
Citalopram (Compound) binds HTR2C (Gene)
Citalopram (Compound) upregulates PLS1 (Gene)
Citalopram (Compound) palliates panic disorder (Disease)
Citalopram (Compound) downregulates RNH1 (Gene)
Citalopram (Compound) causes Allergy aggravated (Side Effect)
Citalopram may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Citalopram may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin