DDInter336 DDInter246
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Budesonide
Celecoxib {u} (Compound) causes {v} (Side Effect) Urinary tract infection
Urinary tract infection {u} (Side Effect) is caused by {v} (Compound) Budesonide
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Paramethasone
Paramethasone {u} (Compound) resembles {v} (Compound) Budesonide
Celecoxib {u} (Compound) causes {v} (Side Effect) Urinary tract infection
Urinary tract infection {u} (Side Effect) is caused by {v} (Compound) Flunisolide
Flunisolide {u} (Compound) resembles {v} (Compound) Budesonide
Celecoxib {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Orciprenaline
Orciprenaline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Budesonide
Celecoxib {u} (Compound) causes {v} (Side Effect) Pollakiuria
Pollakiuria {u} (Side Effect) is caused by {v} (Compound) Pyridostigmine
Pyridostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Budesonide
Celecoxib {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Celecoxib {u} (Compound) binds {v} (Gene) CA14
CA14 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) upregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Budesonide
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Budesonide (Compound)
Celecoxib (Compound) causes Urinary tract infection (Side Effect) and Urinary tract infection (Side Effect) is caused by Budesonide (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paramethasone (Compound) and Paramethasone (Compound) resembles Budesonide (Compound)
Celecoxib (Compound) causes Urinary tract infection (Side Effect) and Urinary tract infection (Side Effect) is caused by Flunisolide (Compound) and Flunisolide (Compound) resembles Budesonide (Compound)
Celecoxib (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Orciprenaline (Compound) and Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Budesonide
Celecoxib (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Pyridostigmine (Compound) and Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Budesonide (Compound)
Celecoxib (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Celecoxib (Compound) binds CA14 (Gene) and CA14 (Gene) is bound by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) upregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Budesonide (Compound)