DDInter458 DDInter1721
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Goitre
Goitre {u} (Side Effect) is caused by {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfamoxole
Sulfamoxole {u} (Compound) resembles {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sulfanilamide
Sulfanilamide {u} (Compound) resembles {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} (Compound) resembles {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Sepsis
Sepsis {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfadiazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Sulfanilamide
Sulfanilamide {u} (Compound) resembles {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) RBKS
RBKS {u} (Gene) is upregulated by {v} (Compound) Sulfathiazole
Sulfathiazole {u} (Compound) resembles {v} (Compound) Sulfadiazine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfadiazine
Cyclosporine {u} (Compound) upregulates {v} (Gene) RBKS
RBKS {u} (Gene) is upregulated by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfadiazine
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfadiazine (Compound)
Cyclosporine (Compound) causes Goitre (Side Effect) and Goitre (Side Effect) is caused by Sulfadiazine (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfamoxole (Compound) and Sulfamoxole (Compound) resembles Sulfadiazine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfanilamide (Compound) and Sulfanilamide (Compound) resembles Sulfadiazine (Compound)
Cyclosporine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole (Compound) resembles Sulfadiazine (Compound)
Cyclosporine (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine
Cyclosporine (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Sulfanilamide (Compound) and Sulfanilamide (Compound) resembles Sulfadiazine (Compound)
Cyclosporine (Compound) upregulates RBKS (Gene) and RBKS (Gene) is upregulated by Sulfathiazole (Compound) and Sulfathiazole (Compound) resembles Sulfadiazine (Compound)
Cyclosporine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pyrimethamine (Compound) and Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine
Cyclosporine (Compound) upregulates RBKS (Gene) and RBKS (Gene) is upregulated by Pyrimethamine (Compound) and Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine