DDInter948 DDInter1962
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market.
Zileuton {u} (Compound) resembles {v} (Compound) Tiaprofenic acid
Zileuton {u} (Compound) resembles {v} (Compound) Salicylamide
Zileuton {u} (Compound) treats {v} (Disease) asthma
Zileuton {u} (Compound) binds {v} (Gene) LTB4R
Zileuton {u} (Compound) upregulates {v} (Gene) GNAI1
Zileuton {u} (Compound) is included by {v} (Pharmacologic Class) 5-Lipoxygenase Inhibitors
Zileuton {u} (Compound) downregulates {v} (Gene) DNAJA3
Zileuton {u} (Compound) causes {v} (Side Effect) Urticaria
Zileuton {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Osilodrostat
Zileuton {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Zileuton (Compound) resembles Tiaprofenic acid (Compound)
Zileuton (Compound) resembles Salicylamide (Compound)
Zileuton (Compound) treats asthma (Disease)
Zileuton (Compound) binds LTB4R (Gene)
Zileuton (Compound) upregulates GNAI1 (Gene)
Zileuton (Compound) is included by 5-Lipoxygenase Inhibitors (Pharmacologic Class)
Zileuton (Compound) downregulates DNAJA3 (Gene)
Zileuton (Compound) causes Urticaria (Side Effect)
Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine