DDInter1042 DDInter1325
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Ofloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Ofloxacin {u} (Compound) binds {v} (Gene) SLC22A4
Ofloxacin {u} (Compound) upregulates {v} (Gene) SELL
Ofloxacin {u} (Compound) palliates {v} (Disease) chronic obstructive pulmonary disease
Ofloxacin {u} (Compound) is included by {v} (Pharmacologic Class) Quinolones
Ofloxacin {u} (Compound) downregulates {v} (Gene) RB1
Ofloxacin {u} (Compound) causes {v} (Side Effect) Petechiae
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentostatin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Procarbazine
Ofloxacin (Compound) resembles Enoxacin (Compound)
Ofloxacin (Compound) resembles Levofloxacin (Compound)
Ofloxacin (Compound) binds SLC22A4 (Gene)
Ofloxacin (Compound) upregulates SELL (Gene)
Ofloxacin (Compound) palliates chronic obstructive pulmonary disease (Disease)
Ofloxacin (Compound) is included by Quinolones (Pharmacologic Class)
Ofloxacin (Compound) downregulates RB1 (Gene)
Ofloxacin (Compound) causes Petechiae (Side Effect)
Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Pentostatin
Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine