DDInter458 DDInter704
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Cyclosporine {u} (Compound) binds {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is bound by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDK5R1
CDK5R1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inhibitors
Cytochrome P450 3A4 Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Everolimus
Cyclosporine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) binds {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is bound by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDK5R1
CDK5R1 {u} (Gene) is regulated by {v} (Gene) SWAP70
SWAP70 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cyclosporine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is regulated by {v} (Gene) CREG1
CREG1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Cyclosporine (Compound) binds FKBP1A (Gene) and FKBP1A (Gene) is bound by Everolimus (Compound)
Cyclosporine (Compound) downregulates CDK5R1 (Gene) and CDK5R1 (Gene) is upregulated by Everolimus (Compound)
Cyclosporine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Everolimus (Compound)
Cyclosporine (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Everolimus (Compound)
Cyclosporine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Everolimus (Compound)
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Everolimus (Compound)
Cyclosporine (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Everolimus (Compound)
Cyclosporine (Compound) binds FKBP1A (Gene) and FKBP1A (Gene) is bound by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Cyclosporine (Compound) downregulates CDK5R1 (Gene) and CDK5R1 (Gene) is regulated by SWAP70 (Gene) and SWAP70 (Gene) is upregulated by Everolimus (Compound)
Cyclosporine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is regulated by CREG1 (Gene) and CREG1 (Gene) is upregulated by Everolimus (Compound)