DDInter1961 DDInter255
A dideoxynucleoside compound in which the 3&#39;-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Zidovudine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Zidovudine {u} (Compound) binds {v} (Gene) TERT
TERT {u} (Gene) is upregulated by {v} (Compound) Busulfan
Zidovudine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Zidovudine {u} (Compound) causes {v} (Side Effect) Rhinitis
Rhinitis {u} (Side Effect) is caused by {v} (Compound) Busulfan
Zidovudine {u} (Compound) binds {v} (Gene) TERT
TERT {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Zidovudine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Zidovudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trifluridine
Trifluridine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Zidovudine {u} (Compound) binds {v} (Gene) TERT
TERT {u} (Gene) is regulated by {v} (Gene) NUDT9
NUDT9 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Zidovudine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Zidovudine {u} (Compound) resembles {v} (Compound) Idoxuridine
Idoxuridine {u} (Compound) upregulates {v} (Gene) EPHA3
EPHA3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Zidovudine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Zidovudine (Compound) binds TERT (Gene) and TERT (Gene) is upregulated by Busulfan (Compound)
Zidovudine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Busulfan (Compound)
Zidovudine (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Busulfan (Compound)
Zidovudine (Compound) binds TERT (Gene) and TERT (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Zidovudine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Busulfan (Compound)
Zidovudine (Compound) binds TERT (Gene) and TERT (Gene) is regulated by NUDT9 (Gene) and NUDT9 (Gene) is upregulated by Busulfan (Compound)
Zidovudine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Zidovudine (Compound) resembles Idoxuridine (Compound) and Idoxuridine (Compound) upregulates EPHA3 (Gene) and EPHA3 (Gene) is upregulated by Busulfan (Compound)