DDInter298 DDInter460
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is treated by {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Capecitabine
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) downregulates {v} (Gene) INPP1
INPP1 {u} (Gene) is upregulated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Cytarabine
Carboplatin {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Cytarabine
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Cytarabine (Compound)
Carboplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Gemcitabine (Compound) and Gemcitabine (Compound) resembles Cytarabine (Compound)
Carboplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cytarabine (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with MYC (Gene) and MYC (Gene) is downregulated by Cytarabine (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Capecitabine (Compound) and Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) downregulates INPP1 (Gene) and INPP1 (Gene) is upregulated by Cytarabine (Compound)
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cytarabine (Compound)
Carboplatin (Compound) binds MPO (Gene) and MPO (Gene) is downregulated by hematologic cancer (Disease) and MPO (Disease) associated with hematologic cancer (Gene) and hematologic cancer (Disease) is treated by Cytarabine (Compound)