DDInter458 DDInter631
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Eltrombopag
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Simvastatin
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eltrombopag
Cyclosporine {u} (Compound) upregulates {v} (Gene) SEC23B
SEC23B {u} (Gene) interacts with {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is bound by {v} (Compound) Eltrombopag
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is regulated by {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is bound by {v} (Compound) Eltrombopag
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is bound by {v} (Compound) Eltrombopag
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is upregulated by {v} (Compound) Simvastatin
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eltrombopag
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Simvastatin
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eltrombopag
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eltrombopag
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1B1
SLCO1B1 {u} (Gene) is bound by {v} (Compound) Simeprevir
Simeprevir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eltrombopag
Cyclosporine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is downregulated by {v} (Compound) Pitavastatin
Pitavastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eltrombopag
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Eltrombopag (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Simvastatin (Compound) and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Cyclosporine (Compound) upregulates SEC23B (Gene) and SEC23B (Gene) interacts with UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Eltrombopag (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is regulated by UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Eltrombopag (Compound)
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Eltrombopag (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is upregulated by Simvastatin (Compound) and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Simvastatin (Compound) and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is downregulated by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Cyclosporine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Simeprevir (Compound) and Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Cyclosporine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is downregulated by Pitavastatin (Compound) and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag