DDInter576 DDInter140
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased since the 1980s owing to numerous side effects, limited efficacy, and slow onset of action. Many if not most gold compounds that were indicated for rheumatoid arthritis therapy have since been replaced with the use of various current disease modifying anti-rheumatic drugs (DMARDs) like methotrexate and others, which are far more effective.
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Quinine
Quinine {u} may lead to a major life threatening interaction when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) downregulates {v} (Gene) COG4
COG4 {u} (Gene) is downregulated by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aurothioglucose
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Aurothioglucose
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Vinblastine (Compound) and TUBB6 (Gene) is upregulated by Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Quinine (Compound) and Quinine may lead to a major life threatening interaction when taken with Aurothioglucose
Disulfiram (Compound) downregulates COG4 (Gene) and COG4 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) downregulates COG4 (Gene) and COG4 (Gene) is downregulated by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Aurothioglucose