DDInter178 DDInter1288
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals. Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market by Bayer in 1996.
Niclosamide {u} (Compound) resembles {v} (Compound) Triclosan
Niclosamide {u} (Compound) resembles {v} (Compound) Diflunisal
Niclosamide {u} (Compound) binds {v} (Gene) CYP1A2
Niclosamide {u} (Compound) upregulates {v} (Gene) C18orf8
Niclosamide {u} (Compound) downregulates {v} (Gene) PMPCA
Niclosamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Niclosamide {u} may lead to a major life threatening interaction when taken with {v} Tizanidine
Niclosamide (Compound) resembles Triclosan (Compound)
Niclosamide (Compound) resembles Diflunisal (Compound)
Niclosamide (Compound) binds CYP1A2 (Gene)
Niclosamide (Compound) upregulates C18orf8 (Gene)
Niclosamide (Compound) downregulates PMPCA (Gene)
Niclosamide may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine
Niclosamide may lead to a major life threatening interaction when taken with Tizanidine