DDInter458 DDInter870
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human population, leading to infections which are followed by life-long dormancy in the host with occasional reactivations and recurrent infections. The seroprevalence of antibodies in adults ranges from 40-100 % with an inverse correlation to socioeconomic status. The transmission of cytomegalovirus infection requires intimate contact with infected excretions such as saliva, urine, cervical and vaginal excretions, semen, breast milk and blood . CMV infection can lead to a high fever and severe organ-specific damage with significant morbidity and mortality rates. Cytomegalovirus (CMV) may lead to a wide spectrum of infection in immunocompetent hosts. Sites most often involved include the lung (severe community-acquired viral pneumonia), liver (transaminitis), spleen (splenomegaly), GI tract (colitis), CNS (encephalitis), the hematologic system (cytopenias), and multisystem involvement . During the span of an individual's life, the virus may reactivate, resulting in repeated shedding and spread of the virus. Molecular mechanisms have been identified by which show that CMVs interfere with the host immune system. Finally, however, the infection is normally controlled by the host's immune response. As a consequence, CMV disease is restricted to the immunocompromised or immunologically immature host, in which it can lead the devastating result of transplant rejection , .
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Sulfasalazine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) upregulates {v} (Gene) CNPY3
CNPY3 {u} (Gene) is upregulated by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is downregulated by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) downregulates {v} (Gene) ITGB5
ITGB5 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) binds {v} (Gene) PPIF
PPIF {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is bound by {v} (Compound) Methotrexate
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Human cytomegalovirus immune globulin
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Sulfasalazine (Compound) and Sulfasalazine may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Flurbiprofen (Compound) and Flurbiprofen may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Flurbiprofen (Compound) and Flurbiprofen may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) downregulates ITGB5 (Gene) and ITGB5 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) binds PPIF (Gene) and PPIF (Gene) is downregulated by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Cyclosporine (Compound) downregulates TYMS (Gene) and TYMS (Gene) is bound by Methotrexate (Compound) and Methotrexate may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin