DDInter600 DDInter1376
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Doxylamine {u} (Compound) resembles {v} (Compound) Toremifene
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Doxylamine {u} (Compound) resembles {v} (Compound) Chloropyramine
Doxylamine {u} (Compound) binds {v} (Gene) HRH1
Doxylamine {u} (Compound) upregulates {v} (Gene) KIT
Doxylamine {u} (Compound) downregulates {v} (Gene) IGFBP2
Doxylamine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clozapine
Doxylamine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Doxylamine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Disopyramide
Doxylamine (Compound) resembles Toremifene (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Doxylamine (Compound) resembles Chloropyramine (Compound)
Doxylamine (Compound) binds HRH1 (Gene)
Doxylamine (Compound) upregulates KIT (Gene)
Doxylamine (Compound) downregulates IGFBP2 (Gene)
Doxylamine (Compound) causes Decreased appetite (Side Effect)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine
Doxylamine may lead to a major life threatening interaction when taken with Zonisamide
Doxylamine (Compound) resembles Disopyramide (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide