DDInter1938 DDInter293
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.
Vincristine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Carbamazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Carbamazepine
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Vincristine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Carbamazepine
Vincristine {u} (Compound) binds {v} (Gene) RALBP1
RALBP1 {u} (Gene) is bound by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Carbamazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} (Compound) resembles {v} (Compound) Carbamazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Azotaemia
Azotaemia {u} (Side Effect) is caused by {v} (Compound) Clindamycin
Clindamycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Neuritis
Neuritis {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Vincristine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Carbamazepine (Compound)
Vincristine (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Carbamazepine (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Vincristine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Phenytoin (Compound) and Phenytoin (Compound) resembles Carbamazepine (Compound)
Vincristine (Compound) binds RALBP1 (Gene) and RALBP1 (Gene) is bound by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Vincristine (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Modafinil (Compound) and Modafinil (Compound) resembles Carbamazepine (Compound)
Vincristine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Cyclobenzaprine (Compound) and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Vincristine (Compound) causes Azotaemia (Side Effect) and Azotaemia (Side Effect) is caused by Clindamycin (Compound) and Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine
Vincristine (Compound) causes Neuritis (Side Effect) and Neuritis (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine