DDInter1566 DDInter105
Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, permeability, and migration of human endothelial cells. VEGFR stimulation also mediates downstream signalling required for angiogenesis and is postulated to be heavily involved in cancer progression, making it a highly likely drug target. In contrast to other agents directed against VEGFR-2, ramucirumab binds a specific epitope on the extracellular domain of VEGFR-2, thereby blocking all VEGF ligands from binding to it. Ramucir
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Ramucirumab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levomilnacipran
Ramucirumab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Milnacipran
Ramucirumab {u} may lead to a major life threatening interaction when taken with {v} Dipyridamole
Ramucirumab {u} may lead to a major life threatening interaction when taken with {v} Plicamycin
Ramucirumab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Flurbiprofen
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran
Ramucirumab may lead to a major life threatening interaction when taken with Dipyridamole
Ramucirumab may lead to a major life threatening interaction when taken with Plicamycin
Ramucirumab may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Ramucirumab may lead to a major life threatening interaction when taken with Flurbiprofen