DDInter576 DDInter1054
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier[Label,A177781]. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson's[Label]. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975[A177781,L6133].
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Levodopa
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy peripheral
Neuropathy peripheral {u} (Side Effect) is caused by {v} (Compound) Levodopa
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Teniposide
Teniposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Disulfiram {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is downregulated by {v} (Compound) Levodopa
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy peripheral
Neuropathy peripheral {u} (Side Effect) is caused by {v} (Compound) Aminosalicylic acid
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Levodopa
Disulfiram {u} (Compound) causes {v} (Side Effect) Lassitude
Lassitude {u} (Side Effect) is caused by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) DRD2
DRD2 {u} (Gene) is bound by {v} (Compound) Levodopa
Disulfiram {u} (Compound) causes {v} (Side Effect) Numbness
Numbness {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levodopa
Disulfiram {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Levodopa
Disulfiram {u} (Compound) binds {v} (Gene) DBH
DBH {u} (Gene) is bound by {v} (Compound) Dopamine
Dopamine {u} (Compound) resembles {v} (Compound) Levodopa
Disulfiram (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Levodopa (Compound)
Disulfiram (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Levodopa (Compound)
Disulfiram (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Teniposide (Compound) and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Disulfiram (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is downregulated by Levodopa (Compound)
Disulfiram (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Aminosalicylic acid (Compound) and Aminosalicylic acid (Compound) resembles Levodopa (Compound)
Disulfiram (Compound) causes Lassitude (Side Effect) and Lassitude (Side Effect) is caused by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is associated with DRD2 (Gene) and DRD2 (Gene) is bound by Levodopa (Compound)
Disulfiram (Compound) causes Numbness (Side Effect) and Numbness (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a minor interaction that can limit clinical effects when taken with Levodopa
Disulfiram (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Melphalan (Compound) and Melphalan (Compound) resembles Levodopa (Compound)
Disulfiram (Compound) binds DBH (Gene) and DBH (Gene) is bound by Dopamine (Compound) and Dopamine (Compound) resembles Levodopa (Compound)