DDInter535 DDInter1490
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide {u} (Compound) binds {v} (Gene) SLC12A3
SLC12A3 {u} (Gene) is bound by {v} (Compound) Polythiazide
Diazoxide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Polythiazide
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide {u} (Compound) binds {v} (Gene) SLC12A3
SLC12A3 {u} (Gene) is bound by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Diazoxide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide {u} (Compound) binds {v} (Gene) SLC12A3
SLC12A3 {u} (Gene) is bound by {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Polythiazide (Compound)
Diazoxide (Compound) binds SLC12A3 (Gene) and SLC12A3 (Gene) is bound by Polythiazide (Compound)
Diazoxide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Diazoxide (Compound) binds SLC12A3 (Gene) and SLC12A3 (Gene) is bound by Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Diazoxide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide
Diazoxide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Polythiazide (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Polythiazide (Compound)
Diazoxide (Compound) binds SLC12A3 (Gene) and SLC12A3 (Gene) is bound by Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Polythiazide (Compound)