DDInter1285 DDInter1853
A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Nevirapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Tretinoin
Nevirapine {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Nevirapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Nevirapine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Nevirapine {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Nevirapine {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) BCL2
BCL2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Nevirapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Nevirapine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Alitretinoin
Alitretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Tretinoin (Compound)
Nevirapine (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Tretinoin (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tretinoin (Compound)
Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Nevirapine (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Nevirapine (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates BCL2 (Gene) and BCL2 (Gene) is downregulated by Tretinoin (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Acitretin and Acitretin (Compound) resembles Tretinoin (Compound)
Nevirapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Alitretinoin (Compound) and Alitretinoin (Compound) resembles Tretinoin (Compound)