DDInter1174 DDInter1853
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} (Compound) resembles {v} (Compound) Tretinoin
Methotrexate {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Methotrexate {u} (Compound) downregulates {v} (Gene) LBR
LBR {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Methotrexate {u} (Compound) downregulates {v} (Gene) GTF2A2
GTF2A2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Methotrexate {u} (Compound) upregulates {v} (Gene) CCDC85B
CCDC85B {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Methotrexate {u} (Compound) binds {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Methotrexate {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Acitretin and Acitretin (Compound) resembles Tretinoin (Compound)
Methotrexate (Compound) upregulates IL1B (Gene) and IL1B (Gene) is upregulated by Tretinoin (Compound)
Methotrexate (Compound) downregulates LBR (Gene) and LBR (Gene) is upregulated by Tretinoin (Compound)
Methotrexate (Compound) downregulates GTF2A2 (Gene) and GTF2A2 (Gene) is downregulated by Tretinoin (Compound)
Methotrexate (Compound) upregulates CCDC85B (Gene) and CCDC85B (Gene) is downregulated by Tretinoin (Compound)
Methotrexate (Compound) binds TYMS (Gene) and TYMS (Gene) is downregulated by Tretinoin (Compound)
Methotrexate (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Tretinoin (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)