DDInter1834 DDInter407
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States.
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Topiramate {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Clofedanol
Topiramate {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} (Compound) resembles {v} (Compound) Clofedanol
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Clotrimazole {u} (Compound) resembles {v} (Compound) Clofedanol
Topiramate {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Tetrabenazine
Tetrabenazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Topiramate {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Clofedanol
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Tapentadol
Tapentadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is treated by {v} (Compound) Amitriptyline
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Topiramate (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Imipramine (Compound) and Imipramine (Compound) resembles Clofedanol (Compound)
Topiramate (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Dextropropoxyphene (Compound) and Dextropropoxyphene (Compound) resembles Clofedanol (Compound)
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clotrimazole (Compound) and Clotrimazole (Compound) resembles Clofedanol (Compound)
Topiramate (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Tetrabenazine (Compound) and Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Topiramate (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Toremifene (Compound) and Toremifene (Compound) resembles Clofedanol (Compound)
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tapentadol (Compound) and Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is treated by Amitriptyline (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol