DDInter255 DDInter1313
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Norfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Pefloxacin
Pefloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Gemifloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Nalidixic acid
Nalidixic acid {u} (Compound) resembles {v} (Compound) Norfloxacin
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Norfloxacin
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Busulfan {u} (Compound) binds {v} (Gene) MGST2
MGST2 {u} (Gene) regulates {v} (Gene) ST7
ST7 {u} (Gene) is upregulated by {v} (Compound) Norfloxacin
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Norfloxacin (Compound)
Busulfan (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Norfloxacin (Compound)
Busulfan (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Norfloxacin (Compound)
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Norfloxacin (Compound)
Busulfan (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Pefloxacin (Compound) and Pefloxacin (Compound) resembles Norfloxacin (Compound)
Busulfan (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Gemifloxacin (Compound) and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Busulfan (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Nalidixic acid (Compound) and Nalidixic acid (Compound) resembles Norfloxacin (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Norfloxacin
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Norfloxacin (Compound)
Busulfan (Compound) binds MGST2 (Gene) and MGST2 (Gene) regulates ST7 (Gene) and ST7 (Gene) is upregulated by Norfloxacin (Compound)