DDInter1853 DDInter495
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in the treatment of acute bacterial skin and skin structure infections.
Tretinoin {u} (Compound) downregulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is upregulated by {v} (Compound) Altretamine
Altretamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Altretamine
Altretamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delafloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may lead to a major life threatening interaction when taken with {v} Delafloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delafloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Teniposide
Teniposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) NCOA3
NCOA3 {u} (Gene) is bound by {v} (Compound) Teniposide
Teniposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is upregulated by {v} (Compound) Teniposide
Teniposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) NCOA3
NCOA3 {u} (Gene) is downregulated by {v} (Compound) Mitomycin
Mitomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Tretinoin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Delafloxacin
Tretinoin (Compound) downregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Altretamine (Compound) and Altretamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Tretinoin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Altretamine (Compound) and Altretamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Tretinoin (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Tretinoin (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Methylprednisolone (Compound) and Methylprednisolone may lead to a major life threatening interaction when taken with Delafloxacin
Tretinoin (Compound) downregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Mycophenolic acid (Compound) and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Tretinoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Teniposide (Compound) and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Tretinoin (Compound) upregulates NCOA3 (Gene) and NCOA3 (Gene) is bound by Teniposide (Compound) and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Tretinoin (Compound) upregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Teniposide (Compound) and Teniposide may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Tretinoin (Compound) upregulates NCOA3 (Gene) and NCOA3 (Gene) is downregulated by Mitomycin (Compound) and Mitomycin may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Tretinoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin