DDInter336 DDInter241
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239]
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Bromfenac
Celecoxib {u} (Compound) downregulates {v} (Gene) ZMIZ1
ZMIZ1 {u} (Gene) is upregulated by {v} (Compound) Bromfenac
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Bromfenac
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Bromfenac
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Balsalazide
Balsalazide {u} (Compound) resembles {v} (Compound) Bromfenac
Celecoxib {u} (Compound) downregulates {v} (Gene) ZMIZ1
ZMIZ1 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Bromfenac
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Bromfenac
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Bromfenac
Celecoxib {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Celecoxib {u} (Compound) downregulates {v} (Gene) ZMIZ1
ZMIZ1 {u} (Gene) regulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Bromfenac
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Bromfenac (Compound)
Celecoxib (Compound) downregulates ZMIZ1 (Gene) and ZMIZ1 (Gene) is upregulated by Bromfenac (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Bromfenac (Compound)
Celecoxib (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Bromfenac (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Balsalazide (Compound) and Balsalazide (Compound) resembles Bromfenac (Compound)
Celecoxib (Compound) downregulates ZMIZ1 (Gene) and ZMIZ1 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Bromfenac (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Ketoprofen (Compound) and Ketoprofen (Compound) resembles Bromfenac (Compound)
Celecoxib (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Bromfenac (Compound)
Celecoxib (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac
Celecoxib (Compound) downregulates ZMIZ1 (Gene) and ZMIZ1 (Gene) regulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Bromfenac (Compound)