DDInter1946 DDInter1055
Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms. Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Voriconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) upregulates {v} (Gene) SELL
SELL {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) upregulates {v} (Gene) SELL
SELL {u} (Gene) is upregulated by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) causes {v} (Side Effect) Euphoric mood
Euphoric mood {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) upregulates {v} (Gene) SELL
SELL {u} (Gene) is regulated by {v} (Gene) SNX7
SNX7 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is upregulated by {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Voriconazole {u} (Compound) binds {v} (Gene) FMO3
FMO3 {u} (Gene) covaries with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Voriconazole (Compound) upregulates SELL (Gene) and SELL (Gene) is upregulated by Levofloxacin (Compound)
Voriconazole (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Voriconazole (Compound) upregulates SELL (Gene) and SELL (Gene) is upregulated by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Voriconazole (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Voriconazole (Compound) causes Euphoric mood (Side Effect) and Euphoric mood (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Voriconazole (Compound) upregulates SELL (Gene) and SELL (Gene) is regulated by SNX7 (Gene) and SNX7 (Gene) is downregulated by Levofloxacin (Compound)
Voriconazole (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is upregulated by chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)
Voriconazole (Compound) binds FMO3 (Gene) and FMO3 (Gene) covaries with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)