DDInter257 DDInter178
Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from mild sedation to general anesthesia. Butalbital has a low degree of selectivity and a narrow therapeutic index. Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine. There have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines thus it is not indicated for such condition. As with other barbiturates
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Butalbital {u} (Compound) resembles {v} (Compound) Aprobarbital
Butalbital {u} (Compound) resembles {v} (Compound) Secobarbital
Butalbital {u} (Compound) binds {v} (Gene) CHRNA4
Butalbital {u} (Compound) palliates {v} (Disease) migraine
Butalbital {u} (Compound) is included by {v} (Pharmacologic Class) Barbiturates
Butalbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Butalbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Butalbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ribociclib
Butalbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcifediol
Butalbital {u} may lead to a major life threatening interaction when taken with {v} Hemin
Butalbital (Compound) resembles Aprobarbital (Compound)
Butalbital (Compound) resembles Secobarbital (Compound)
Butalbital (Compound) binds CHRNA4 (Gene)
Butalbital (Compound) palliates migraine (Disease)
Butalbital (Compound) is included by Barbiturates (Pharmacologic Class)
Butalbital may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Butalbital may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Calcifediol
Butalbital may lead to a major life threatening interaction when taken with Hemin