DDInter947 DDInter576
Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propylthiouracil
Propylthiouracil {u} (Compound) binds {v} (Gene) DBH
DBH {u} (Gene) is bound by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} (Compound) downregulates {v} (Gene) FOSL1
FOSL1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nefazodone
Nefazodone {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Maraviroc {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valproic acid
Valproic acid {u} (Compound) binds {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Interferon beta-1a {u} may lead to a major life threatening interaction when taken with {v} Zidovudine
Zidovudine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CXCL8
CXCL8 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Interferon beta-1a {u} may lead to a major life threatening interaction when taken with {v} Zidovudine
Zidovudine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Propylthiouracil and Propylthiouracil (Compound) binds DBH (Gene) and DBH (Gene) is bound by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone (Compound) downregulates FOSL1 (Gene) and FOSL1 (Gene) is upregulated by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc and Maraviroc (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic acid (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Disulfiram (Compound)
Interferon beta-1a may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac (Compound) binds CXCL8 (Gene) and CXCL8 (Gene) is upregulated by Disulfiram (Compound)
Interferon beta-1a may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Disulfiram (Compound)