DDInter1233 DDInter1435
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Mitotane {u} (Compound) binds {v} (Gene) CYP11B1
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
Mitotane {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inducers
Mitotane {u} (Compound) downregulates {v} (Gene) PEG10
Mitotane {u} (Compound) causes {v} (Side Effect) Digestion impaired
Mitotane (Compound) resembles Carbinoxamine (Compound)
Mitotane (Compound) binds CYP11B1 (Gene)
Mitotane (Compound) upregulates ADGRE5 (Gene)
Mitotane (Compound) is included by Cytochrome P450 3A4 Inducers (Pharmacologic Class)
Mitotane (Compound) downregulates PEG10 (Gene)
Mitotane (Compound) causes Digestion impaired (Side Effect)