DDInter576 DDInter1653
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Selegiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Selegiline
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Selegiline
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Prasugrel
Prasugrel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Selegiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Selegiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuritis
Neuritis {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may lead to a major life threatening interaction when taken with {v} Selegiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Phenylephrine
Phenylephrine {u} may lead to a major life threatening interaction when taken with {v} Selegiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Lisdexamfetamine
Lisdexamfetamine {u} (Compound) resembles {v} (Compound) Selegiline
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Selegiline
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) resembles {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Selegiline
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Selegiline (Compound)
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Selegiline (Compound)
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Phenelzine (Compound) and Phenelzine (Compound) resembles Selegiline (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Prasugrel (Compound) and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Selegiline
Disulfiram (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Phenelzine (Compound) and Phenelzine (Compound) resembles Selegiline (Compound)
Disulfiram (Compound) causes Neuritis (Side Effect) and Neuritis (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may lead to a major life threatening interaction when taken with Selegiline
Disulfiram (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Phenylephrine (Compound) and Phenylephrine may lead to a major life threatening interaction when taken with Selegiline
Disulfiram (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Lisdexamfetamine (Compound) and Lisdexamfetamine (Compound) resembles Selegiline (Compound)
Disulfiram (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Selegiline
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) resembles endogenous depression (Disease) and endogenous depression (Disease) is palliated by Selegiline (Compound)