DDInter696 DDInter576
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Ethotoin {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) is regulated by {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) downregulates {v} (Gene) COG2
COG2 {u} (Gene) is regulated by {v} (Gene) IL11
IL11 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) resembles {v} (Compound) Primidone
Primidone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) resembles {v} (Compound) Methsuximide
Methsuximide {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) upregulates {v} (Gene) SPAG4
SPAG4 {u} (Gene) regulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Disulfiram
Ethotoin (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Disulfiram (Compound)
Ethotoin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Ethotoin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Disulfiram (Compound)
Ethotoin (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is regulated by MOK (Gene) and MOK (Gene) is upregulated by Disulfiram (Compound)
Ethotoin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Ethotoin (Compound) downregulates COG2 (Gene) and COG2 (Gene) is regulated by IL11 (Gene) and IL11 (Gene) is upregulated by Disulfiram (Compound)
Ethotoin (Compound) resembles Primidone (Compound) and Primidone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Disulfiram (Compound)
Ethotoin (Compound) resembles Methsuximide (Compound) and Methsuximide (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Disulfiram (Compound)
Ethotoin (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) regulates RELB (Gene) and RELB (Gene) is upregulated by Disulfiram (Compound)
Ethotoin (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Disulfiram (Compound)