DDInter1276 DDInter1694
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval of the medication is supported by data from three double-blind, placebo-controlled trials and two open-label trials which showed that the onset of action was approximately 1.0 hour and the median time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving normal potassium levels within 48 hours following administration. The treatment effect was maintained for up to 12 months.
Nelfinavir {u} (Compound) resembles {v} (Compound) Mitiglinide
Nelfinavir {u} (Compound) resembles {v} (Compound) Indinavir
Nelfinavir {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
Nelfinavir {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Nelfinavir {u} (Compound) upregulates {v} (Gene) AARS
Nelfinavir {u} (Compound) downregulates {v} (Gene) RPIA
Nelfinavir {u} (Compound) causes {v} (Side Effect) Injury
Nelfinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ranitidine
Nelfinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Nelfinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Nelfinavir (Compound) resembles Mitiglinide (Compound)
Nelfinavir (Compound) resembles Indinavir (Compound)
Nelfinavir (Compound) treats acquired immunodeficiency syndrome (Disease)
Nelfinavir (Compound) binds CYP3A7-CYP3A51P (Gene)
Nelfinavir (Compound) upregulates AARS (Gene)
Nelfinavir (Compound) downregulates RPIA (Gene)
Nelfinavir (Compound) causes Injury (Side Effect)
Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Ranitidine
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro