DDInter255 DDInter1335
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Busulfan {u} (Compound) downregulates {v} (Gene) MAPK1IP1L
MAPK1IP1L {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) upregulates {v} (Gene) TEX10
TEX10 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) downregulates {v} (Gene) AARS
AARS {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) upregulates {v} (Gene) PARP1
PARP1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) downregulates {v} (Gene) MAPK1IP1L
MAPK1IP1L {u} (Gene) regulates {v} (Gene) BHLHE40
BHLHE40 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) downregulates {v} (Gene) DDX42
DDX42 {u} (Gene) is regulated by {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) upregulates {v} (Gene) TEX10
TEX10 {u} (Gene) is regulated by {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) upregulates {v} (Gene) NUDT9
NUDT9 {u} (Gene) regulates {v} (Gene) FOS
FOS {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) interacts with {v} (Gene) RPL3
RPL3 {u} (Gene) is bound by {v} (Compound) Omacetaxine mepesuccinate
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) AKR1A1
AKR1A1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Busulfan (Compound) downregulates MAPK1IP1L (Gene) and MAPK1IP1L (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) upregulates TEX10 (Gene) and TEX10 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) downregulates AARS (Gene) and AARS (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) upregulates PARP1 (Gene) and PARP1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) downregulates MAPK1IP1L (Gene) and MAPK1IP1L (Gene) regulates BHLHE40 (Gene) and BHLHE40 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) downregulates DDX42 (Gene) and DDX42 (Gene) is regulated by RELB (Gene) and RELB (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) upregulates TEX10 (Gene) and TEX10 (Gene) is regulated by SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) upregulates NUDT9 (Gene) and NUDT9 (Gene) regulates FOS (Gene) and FOS (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) interacts with RPL3 (Gene) and RPL3 (Gene) is bound by Omacetaxine mepesuccinate (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates AKR1A1 (Gene) and AKR1A1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)