DDInter387 DDInter178
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Cisplatin {u} (Compound) treats {v} (Disease) testicular cancer
Cisplatin {u} (Compound) binds {v} (Gene) SLC31A2
Cisplatin {u} (Compound) is included by {v} (Pharmacologic Class) Platinum-containing Compounds
Cisplatin {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Cisplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lithium carbonate
Cisplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clostridium tetani toxoid antigen (formaldehyde inactivated)
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alefacept
Cisplatin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Cisplatin {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cisplatin (Compound) treats testicular cancer (Disease)
Cisplatin (Compound) binds SLC31A2 (Gene)
Cisplatin (Compound) is included by Platinum-containing Compounds (Pharmacologic Class)
Cisplatin (Compound) causes Anaphylactic shock (Side Effect)
Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Cisplatin may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept
Cisplatin may lead to a major life threatening interaction when taken with Iothalamic acid
Cisplatin may lead to a major life threatening interaction when taken with Cladribine