DDInter336 DDInter1861
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Trichlormethiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Benzthiazide
Benzthiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA5B
CA5B {u} (Gene) is bound by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Polythiazide
Polythiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) regulates {v} (Gene) PFN1
PFN1 {u} (Gene) is downregulated by {v} (Compound) Trichlormethiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Glycopyrronium
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trichlormethiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Nabilone
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trichlormethiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trichlormethiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trichlormethiazide
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Trichlormethiazide (Compound)
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Benzthiazide (Compound) and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Celecoxib (Compound) binds CA5B (Gene) and CA5B (Gene) is bound by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Trichlormethiazide (Compound)
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound) and Polythiazide (Compound) resembles Trichlormethiazide (Compound)
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Trichlormethiazide (Compound)
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) regulates PFN1 (Gene) and PFN1 (Gene) is downregulated by Trichlormethiazide (Compound)
Celecoxib (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Glycopyrronium (Compound) and Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide
Celecoxib (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Nabilone (Compound) and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide
Celecoxib (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide
Celecoxib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Mepenzolate (Compound) and Mepenzolate may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide