DDInter1158 DDInter405
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Mesalazine {u} (Compound) downregulates {v} (Gene) TERF2IP
TERF2IP {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Mesalazine {u} (Compound) downregulates {v} (Gene) KIF20A
KIF20A {u} (Gene) is downregulated by {v} (Compound) Clofarabine
Mesalazine {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Clofarabine
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Mesalazine {u} (Compound) resembles {v} (Compound) Methyldopa
Methyldopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Clofarabine
Mesalazine {u} (Compound) downregulates {v} (Gene) TERF2IP
TERF2IP {u} (Gene) is upregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Clofarabine
Mesalazine {u} (Compound) downregulates {v} (Gene) KIF20A
KIF20A {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Clofarabine
Mesalazine {u} (Compound) downregulates {v} (Gene) VPS28
VPS28 {u} (Gene) is downregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Clofarabine
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Clofarabine (Compound)
Mesalazine (Compound) downregulates TERF2IP (Gene) and TERF2IP (Gene) is upregulated by Clofarabine (Compound)
Mesalazine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Clofarabine (Compound)
Mesalazine (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Clofarabine (Compound)
Mesalazine (Compound) resembles Diflunisal (Compound) and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
Mesalazine (Compound) resembles Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Clofarabine (Compound)
Mesalazine (Compound) downregulates TERF2IP (Gene) and TERF2IP (Gene) is upregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Clofarabine (Compound)
Mesalazine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Clofarabine (Compound)
Mesalazine (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Clofarabine