DDInter655 DDInter576
An anthracycline which is the 4&#39;-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Epirubicin {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) upregulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) downregulates {v} (Gene) C2CD5
C2CD5 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) regulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) upregulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) regulates {v} (Gene) MEF2C
MEF2C {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) upregulates {v} (Gene) MEF2C
MEF2C {u} (Gene) is regulated by {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) downregulates {v} (Gene) DNAJB1
DNAJB1 {u} (Gene) interacts with {v} (Gene) DNAJC3
DNAJC3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin {u} (Compound) downregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Epirubicin (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Epirubicin (Compound) upregulates NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Epirubicin (Compound) downregulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Disulfiram (Compound)
Epirubicin (Compound) binds TOP2A (Gene) and Epirubicin (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is downregulated by Disulfiram (Compound)
Epirubicin (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Disulfiram (Compound)
Epirubicin (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) regulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Disulfiram (Compound)
Epirubicin (Compound) upregulates NFKB2 (Gene) and NFKB2 (Gene) regulates MEF2C (Gene) and MEF2C (Gene) is upregulated by Disulfiram (Compound)
Epirubicin (Compound) upregulates MEF2C (Gene) and MEF2C (Gene) is regulated by NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Epirubicin (Compound) downregulates DNAJB1 (Gene) and DNAJB1 (Gene) interacts with DNAJC3 (Gene) and DNAJC3 (Gene) is upregulated by Disulfiram (Compound)
Epirubicin (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)