DDInter548 DDInter1335
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Diethylstilbestrol {u} (Compound) upregulates {v} (Gene) CCP110
CCP110 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) upregulates {v} (Gene) CCP110
CCP110 {u} (Gene) regulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} (Compound) upregulates {v} (Gene) ZNF274
ZNF274 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) upregulates {v} (Gene) CCP110
CCP110 {u} (Gene) is regulated by {v} (Gene) HOOK2
HOOK2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) upregulates {v} (Gene) IKBKE
IKBKE {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} (Compound) downregulates {v} (Gene) TSPAN3
TSPAN3 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) interacts with {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentamidine
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) downregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Diethylstilbestrol (Compound) upregulates CCP110 (Gene) and CCP110 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Diethylstilbestrol (Compound) upregulates CCP110 (Gene) and CCP110 (Gene) regulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine (Compound) upregulates ZNF274 (Gene) and ZNF274 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) upregulates CCP110 (Gene) and CCP110 (Gene) is regulated by HOOK2 (Gene) and HOOK2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine (Compound) downregulates TSPAN3 (Gene) and TSPAN3 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) interacts with PGRMC1 (Gene) and PGRMC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)