DDInter1298 DDInter278
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Nisoldipine {u} (Compound) resembles {v} (Compound) Nimodipine
Nisoldipine {u} (Compound) resembles {v} (Compound) Amlodipine
Nisoldipine {u} (Compound) treats {v} (Disease) hypertension
Nisoldipine {u} (Compound) binds {v} (Gene) ABCB1
Nisoldipine {u} (Compound) upregulates {v} (Gene) HMOX1
Nisoldipine {u} (Compound) is included by {v} (Pharmacologic Class) Dihydropyridines
Nisoldipine {u} (Compound) downregulates {v} (Gene) CDC20
Nisoldipine {u} (Compound) causes {v} (Side Effect) Weight decreased
Nisoldipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Nisoldipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Nisoldipine (Compound) resembles Nimodipine (Compound)
Nisoldipine (Compound) resembles Amlodipine (Compound)
Nisoldipine (Compound) treats hypertension (Disease)
Nisoldipine (Compound) binds ABCB1 (Gene)
Nisoldipine (Compound) upregulates HMOX1 (Gene)
Nisoldipine (Compound) is included by Dihydropyridines (Pharmacologic Class)
Nisoldipine (Compound) downregulates CDC20 (Gene)
Nisoldipine (Compound) causes Weight decreased (Side Effect)
Nisoldipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Nisoldipine may cause a minor interaction that can limit clinical effects when taken with Theophylline