DDInter1554 DDInter856
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Quinapril {u} (Compound) resembles {v} (Compound) Trandolapril
Quinapril {u} (Compound) resembles {v} (Compound) Benazepril
Quinapril {u} (Compound) treats {v} (Disease) hypertension
Quinapril {u} (Compound) binds {v} (Gene) SLC15A2
Quinapril {u} (Compound) causes {v} (Side Effect) Photosensitivity reaction
Quinapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium bicarbonate
Quinapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Erythropoietin
Quinapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dalteparin
Quinapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urokinase
Quinapril {u} may lead to a major life threatening interaction when taken with {v} Potassium Iodide
Quinapril (Compound) resembles Trandolapril (Compound)
Quinapril (Compound) resembles Benazepril (Compound)
Quinapril (Compound) treats hypertension (Disease)
Quinapril (Compound) binds SLC15A2 (Gene)
Quinapril (Compound) causes Photosensitivity reaction (Side Effect)
Quinapril may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Quinapril may cause a minor interaction that can limit clinical effects when taken with Erythropoietin
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Urokinase
Quinapril may lead to a major life threatening interaction when taken with Potassium Iodide