DDInter1244 DDInter534
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 . Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect . This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy .
Morphine {u} may lead to a major life threatening interaction when taken with {v} Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} may lead to a major life threatening interaction when taken with {v} Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clomipramine
Clomipramine {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} may lead to a major life threatening interaction when taken with {v} Lorazepam
Lorazepam {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} may lead to a major life threatening interaction when taken with {v} Temazepam
Temazepam {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Diazepam
Morphine {u} (Compound) causes {v} (Side Effect) Thirst
Thirst {u} (Side Effect) is caused by {v} (Compound) Diazepam
Morphine {u} may lead to a major life threatening interaction when taken with {v} Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Flunitrazepam
Flunitrazepam {u} (Compound) resembles {v} (Compound) Diazepam
Morphine {u} may lead to a major life threatening interaction when taken with {v} Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Bromazepam
Bromazepam {u} (Compound) resembles {v} (Compound) Diazepam
Morphine may lead to a major life threatening interaction when taken with Quazepam and Quazepam (Compound) resembles Diazepam (Compound)
Morphine may lead to a major life threatening interaction when taken with Oxazepam and Oxazepam (Compound) resembles Diazepam (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Diazepam (Compound)
Morphine may lead to a major life threatening interaction when taken with Lorazepam and Lorazepam (Compound) resembles Diazepam (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Diazepam (Compound)
Morphine may lead to a major life threatening interaction when taken with Temazepam and Temazepam (Compound) resembles Diazepam (Compound)
Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diazepam (Compound)
Morphine (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Diazepam (Compound)
Morphine may lead to a major life threatening interaction when taken with Quazepam and Quazepam (Compound) resembles Flunitrazepam (Compound) and Flunitrazepam (Compound) resembles Diazepam (Compound)
Morphine may lead to a major life threatening interaction when taken with Oxazepam and Oxazepam (Compound) resembles Bromazepam (Compound) and Bromazepam (Compound) resembles Diazepam (Compound)