DDInter1055 DDInter740
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.
Levofloxacin {u} (Compound) downregulates {v} (Gene) SUPV3L1
SUPV3L1 {u} (Gene) is downregulated by {v} (Compound) Flecainide
Levofloxacin {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Flecainide
Levofloxacin {u} (Compound) downregulates {v} (Gene) SUPV3L1
SUPV3L1 {u} (Gene) regulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Flecainide
Levofloxacin {u} (Compound) downregulates {v} (Gene) SHB
SHB {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Flecainide
Levofloxacin {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Levofloxacin {u} (Compound) downregulates {v} (Gene) SUPV3L1
SUPV3L1 {u} (Gene) is regulated by {v} (Gene) EXT1
EXT1 {u} (Gene) is downregulated by {v} (Compound) Flecainide
Levofloxacin {u} (Compound) downregulates {v} (Gene) PAPD7
PAPD7 {u} (Gene) regulates {v} (Gene) RRM2
RRM2 {u} (Gene) is downregulated by {v} (Compound) Flecainide
Levofloxacin {u} (Compound) upregulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Levofloxacin {u} (Compound) downregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is downregulated by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Levofloxacin (Compound) downregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is downregulated by Flecainide (Compound)
Levofloxacin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Flecainide (Compound)
Levofloxacin (Compound) downregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) regulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Flecainide (Compound)
Levofloxacin (Compound) downregulates SHB (Gene) and SHB (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Flecainide (Compound)
Levofloxacin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Levofloxacin (Compound) downregulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is regulated by EXT1 (Gene) and EXT1 (Gene) is downregulated by Flecainide (Compound)
Levofloxacin (Compound) downregulates PAPD7 (Gene) and PAPD7 (Gene) regulates RRM2 (Gene) and RRM2 (Gene) is downregulated by Flecainide (Compound)
Levofloxacin (Compound) upregulates CPVL (Gene) and CPVL (Gene) is upregulated by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Levofloxacin (Compound) downregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)