DDInter1834 DDInter1873
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Topiramate {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Trimethobenzamide
Topiramate {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Midazolam
Midazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Topiramate {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Papaverine
Papaverine {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Papaverine
Papaverine {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Topiramate {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is upregulated by {v} (Compound) Trimethobenzamide
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Colchicine {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Levetiracetam
Levetiracetam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Trimethobenzamide
Topiramate (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Topiramate (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Topiramate (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Papaverine (Compound) and Papaverine (Compound) resembles Trimethobenzamide (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Papaverine (Compound) and Papaverine (Compound) resembles Trimethobenzamide (Compound)
Topiramate (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Trimethobenzamide (Compound)
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by Colchicine (Compound) and Colchicine (Compound) resembles Trimethobenzamide (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Levetiracetam (Compound) and Levetiracetam may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Trimethobenzamide