DDInter856 DDInter292
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Captopril {u} (Compound) resembles {v} (Compound) Enalapril
Captopril {u} (Compound) treats {v} (Disease) coronary artery disease
Captopril {u} (Compound) binds {v} (Gene) MMP2
Captopril {u} (Compound) upregulates {v} (Gene) RELB
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
Captopril {u} (Compound) causes {v} (Side Effect) Diabetic
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium citrate
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darbepoetin alfa
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glulisine
Captopril (Compound) resembles Enalapril (Compound)
Captopril (Compound) treats coronary artery disease (Disease)
Captopril (Compound) binds MMP2 (Gene)
Captopril (Compound) upregulates RELB (Gene)
Captopril (Compound) downregulates NPC1 (Gene)
Captopril (Compound) causes Diabetic (Side Effect)
Captopril may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Captopril may cause a minor interaction that can limit clinical effects when taken with Darbepoetin alfa
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine