DDInter528 DDInter1016
Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the market in Europe and the United States. The drug is often referred to as the general form, "propoxyphene", however only the dextro-isomer (dextropropoxyphene) has any analgesic effect. The levo-isomer appears to exhibit a very limited antitussive effect.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Dextropropoxyphene {u} (Compound) resembles {v} (Compound) Disopyramide
Dextropropoxyphene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Dextropropoxyphene {u} (Compound) resembles {v} (Compound) Levacetylmethadol
Dextropropoxyphene {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Dextropropoxyphene {u} (Compound) upregulates {v} (Gene) UBQLN2
Dextropropoxyphene {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Dextropropoxyphene {u} (Compound) downregulates {v} (Gene) RUVBL1
Dextropropoxyphene {u} (Compound) causes {v} (Side Effect) Asthenia
Dextropropoxyphene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Dextropropoxyphene may lead to a major life threatening interaction when taken with Tamoxifen
Dextropropoxyphene (Compound) resembles Disopyramide (Compound)
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Dextropropoxyphene (Compound) resembles Levacetylmethadol (Compound)
Dextropropoxyphene (Compound) binds CYP3A7-CYP3A51P (Gene)
Dextropropoxyphene (Compound) upregulates UBQLN2 (Gene)
Dextropropoxyphene (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Dextropropoxyphene (Compound) downregulates RUVBL1 (Gene)
Dextropropoxyphene (Compound) causes Asthenia (Side Effect)
Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole