DDInter1853 DDInter383
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Tretinoin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Cinoxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Epirubicin
Epirubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Idarubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) MBOAT7
MBOAT7 {u} (Gene) covaries with {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Cinoxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) covaries with {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Cinoxacin
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Cinoxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Idarubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Tretinoin {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cinoxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Tingling sensation
Tingling sensation {u} (Side Effect) is caused by {v} (Compound) Calcium acetate
Calcium acetate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cinoxacin
Tretinoin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cinoxacin (Compound)
Tretinoin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Epirubicin (Compound) and Epirubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Tretinoin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Idarubicin (Compound) and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Tretinoin (Compound) downregulates MBOAT7 (Gene) and MBOAT7 (Gene) covaries with SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Cinoxacin (Compound)
Tretinoin (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) covaries with SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Cinoxacin (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Isotretinoin (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cinoxacin (Compound)
Tretinoin (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Idarubicin (Compound) and Idarubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Tretinoin (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Tretinoin (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Cinoxacin
Tretinoin (Compound) causes Tingling sensation (Side Effect) and Tingling sensation (Side Effect) is caused by Calcium acetate (Compound) and Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Cinoxacin