DDInter1838 DDInter1662
Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Chloramphenicol {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) palliates {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Bromfenac {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Topotecan {u} (Compound) downregulates {v} (Gene) TMEM97
TMEM97 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Tositumomab {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Deferiprone {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Sertraline
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) palliates endogenous depression (Disease) and endogenous depression (Disease) is palliated by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is downregulated by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan (Compound) downregulates TMEM97 (Gene) and TMEM97 (Gene) is upregulated by Sertraline (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Deferiprone and Deferiprone (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Sertraline (Compound)