DDInter856 DDInter1756
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Telavancin {u} (Compound) resembles {v} (Compound) Oritavancin
Telavancin {u} (Compound) resembles {v} (Compound) Vancomycin
Telavancin {u} (Compound) is included by {v} (Pharmacologic Class) Lipoglycopeptides
Telavancin {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Telavancin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Telavancin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Castor oil
Telavancin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Telavancin {u} may lead to a major life threatening interaction when taken with {v} Vemurafenib
Telavancin {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Telavancin (Compound) resembles Oritavancin (Compound)
Telavancin (Compound) resembles Vancomycin (Compound)
Telavancin (Compound) is included by Lipoglycopeptides (Pharmacologic Class)
Telavancin (Compound) causes Abdominal discomfort (Side Effect)
Telavancin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Telavancin may lead to a major life threatening interaction when taken with Vemurafenib
Telavancin may lead to a major life threatening interaction when taken with Dolasetron