DDInter601 DDInter1960
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. Due to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Dronabinol {u} (Compound) resembles {v} (Compound) Nabilone
Dronabinol {u} (Compound) binds {v} (Gene) CNR1
Dronabinol {u} (Compound) is included by {v} (Pharmacologic Class) Cannabinoids
Dronabinol {u} (Compound) causes {v} (Side Effect) Sinusitis
Dronabinol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nifedipine
Dronabinol {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Dronabinol {u} may lead to a major life threatening interaction when taken with {v} Tramadol
Dronabinol (Compound) resembles Nabilone (Compound)
Dronabinol (Compound) binds CNR1 (Gene)
Dronabinol (Compound) is included by Cannabinoids (Pharmacologic Class)
Dronabinol (Compound) causes Sinusitis (Side Effect)
Dronabinol may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine
Dronabinol may lead to a major life threatening interaction when taken with Iohexol
Dronabinol may lead to a major life threatening interaction when taken with Tramadol