DDInter1804 DDInter1570
Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Ticlopidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ranolazine
Ticlopidine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Ranolazine
Ticlopidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Ranolazine
Ticlopidine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Guaifenesin
Guaifenesin {u} (Compound) resembles {v} (Compound) Ranolazine
Ticlopidine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Ranolazine
Ticlopidine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Ranolazine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Eprazinone
Eprazinone {u} (Compound) resembles {v} (Compound) Ranolazine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atomoxetine
Atomoxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ranolazine
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Acetophenazine
Acetophenazine {u} (Compound) resembles {v} (Compound) Ranolazine
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Thioridazine
Thioridazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ranolazine
Ticlopidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ranolazine (Compound)
Ticlopidine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Ranolazine (Compound)
Ticlopidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bupivacaine (Compound) and Bupivacaine (Compound) resembles Ranolazine (Compound)
Ticlopidine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Guaifenesin (Compound) and Guaifenesin (Compound) resembles Ranolazine (Compound)
Ticlopidine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Bupivacaine (Compound) and Bupivacaine (Compound) resembles Ranolazine (Compound)
Ticlopidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Ranolazine (Compound)
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Eprazinone (Compound) and Eprazinone (Compound) resembles Ranolazine (Compound)
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ranolazine (Compound)
Ticlopidine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Acetophenazine (Compound) and Acetophenazine (Compound) resembles Ranolazine (Compound)
Ticlopidine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ranolazine (Compound)