DDInter458 DDInter472
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Danazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Danazol
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is upregulated by {v} (Compound) Danazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) TP53
TP53 {u} (Gene) is downregulated by {v} (Compound) Danazol
Cyclosporine {u} (Compound) downregulates {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Danazol
Cyclosporine {u} (Compound) causes {v} (Side Effect) Acne
Acne {u} (Side Effect) is caused by {v} (Compound) Danazol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) resembles {v} (Compound) Danazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Danazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) NANS
NANS {u} (Gene) is regulated by {v} (Gene) ESPL1
ESPL1 {u} (Gene) is downregulated by {v} (Compound) Danazol
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSPYL2
TSPYL2 {u} (Gene) is regulated by {v} (Gene) COPB2
COPB2 {u} (Gene) is upregulated by {v} (Compound) Danazol
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Danazol (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Danazol (Compound)
Cyclosporine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is upregulated by Danazol (Compound)
Cyclosporine (Compound) upregulates TP53 (Gene) and TP53 (Gene) is downregulated by Danazol (Compound)
Cyclosporine (Compound) downregulates PNP (Gene) and PNP (Gene) is downregulated by Danazol (Compound)
Cyclosporine (Compound) causes Acne (Side Effect) and Acne (Side Effect) is caused by Danazol (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethinylestradiol (Compound) and Ethinylestradiol (Compound) resembles Danazol (Compound)
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Norethisterone (Compound) and Norethisterone (Compound) resembles Danazol (Compound)
Cyclosporine (Compound) upregulates NANS (Gene) and NANS (Gene) is regulated by ESPL1 (Gene) and ESPL1 (Gene) is downregulated by Danazol (Compound)
Cyclosporine (Compound) upregulates TSPYL2 (Gene) and TSPYL2 (Gene) is regulated by COPB2 (Gene) and COPB2 (Gene) is upregulated by Danazol (Compound)