DDInter1010 DDInter856
Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Ketorolac {u} (Compound) resembles {v} (Compound) Fenbufen
Ketorolac {u} (Compound) resembles {v} (Compound) Oxybenzone
Ketorolac {u} (Compound) binds {v} (Gene) PTGS1
Ketorolac {u} (Compound) upregulates {v} (Gene) FAIM
Ketorolac {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Ketorolac {u} (Compound) downregulates {v} (Gene) RPS4Y1
Ketorolac {u} (Compound) causes {v} (Side Effect) Back pain
Ketorolac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ketorolac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trastuzumab emtansine
Ketorolac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anistreplase
Ketorolac (Compound) resembles Fenbufen (Compound)
Ketorolac (Compound) resembles Oxybenzone (Compound)
Ketorolac (Compound) binds PTGS1 (Gene)
Ketorolac (Compound) upregulates FAIM (Gene)
Ketorolac (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Ketorolac (Compound) downregulates RPS4Y1 (Gene)
Ketorolac (Compound) causes Back pain (Side Effect)
Ketorolac may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase