DDInter336 DDInter1124
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Celecoxib {u} (Compound) binds {v} (Gene) ORM1
ORM1 {u} (Gene) is bound by {v} (Compound) Maprotiline
Celecoxib {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Celecoxib {u} (Compound) binds {v} (Gene) ORM1
ORM1 {u} (Gene) is bound by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Maprotiline
Celecoxib {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Sertraline
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Celecoxib {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Maprotiline
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Maprotiline
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Sertraline
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Celecoxib {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Maprotiline
Celecoxib {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Celecoxib {u} (Compound) causes {v} (Side Effect) Bronchospasm
Bronchospasm {u} (Side Effect) is caused by {v} (Compound) Quinine
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Celecoxib (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Maprotiline (Compound)
Celecoxib (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Maprotiline (Compound)
Celecoxib (Compound) binds ORM1 (Gene) and ORM1 (Gene) is bound by Imipramine (Compound) and Imipramine (Compound) resembles Maprotiline (Compound)
Celecoxib (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Sertraline (Compound) and Sertraline (Compound) resembles Maprotiline (Compound)
Celecoxib (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Protriptyline (Compound) and Protriptyline (Compound) resembles Maprotiline (Compound)
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Maprotiline (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Sertraline (Compound) and Sertraline (Compound) resembles Maprotiline (Compound)
Celecoxib (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Maprotiline
Celecoxib (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline
Celecoxib (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Quinine (Compound) and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline