DDInter998 DDInter1236
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Modafinil
Ivermectin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Modafinil
Ivermectin {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Modafinil
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Modafinil
Ivermectin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Carbamazepine
Carbamazepine {u} (Compound) resembles {v} (Compound) Modafinil
Ivermectin {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Modafinil
Ivermectin {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Ivermectin {u} (Compound) binds {v} (Gene) NR1H4
NR1H4 {u} (Gene) regulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Modafinil
Ivermectin {u} (Compound) causes {v} (Side Effect) Loose stools
Loose stools {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Ivermectin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Modafinil
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Modafinil (Compound)
Ivermectin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Modafinil (Compound)
Ivermectin (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Modafinil (Compound)
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Modafinil (Compound)
Ivermectin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Carbamazepine (Compound) and Carbamazepine (Compound) resembles Modafinil (Compound)
Ivermectin (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Modafinil (Compound)
Ivermectin (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a minor interaction that can limit clinical effects when taken with Modafinil
Ivermectin (Compound) binds NR1H4 (Gene) and NR1H4 (Gene) regulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Modafinil (Compound)
Ivermectin (Compound) causes Loose stools (Side Effect) and Loose stools (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Ivermectin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Modafinil