DDInter395 DDInter1376
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Clemastine {u} (Compound) resembles {v} (Compound) Eletriptan
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Clemastine {u} (Compound) resembles {v} (Compound) Mesoridazine
Clemastine {u} (Compound) binds {v} (Gene) CYP3A4
Clemastine {u} (Compound) upregulates {v} (Gene) INSIG1
Clemastine {u} (Compound) downregulates {v} (Gene) IKBKAP
Clemastine {u} (Compound) causes {v} (Side Effect) Chest tightness
Clemastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Clemastine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Clemastine (Compound) resembles Eletriptan (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clemastine (Compound) resembles Mesoridazine (Compound)
Clemastine (Compound) binds CYP3A4 (Gene)
Clemastine (Compound) upregulates INSIG1 (Gene)
Clemastine (Compound) downregulates IKBKAP (Gene)
Clemastine (Compound) causes Chest tightness (Side Effect)
Clemastine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trospium
Clemastine may lead to a major life threatening interaction when taken with Zonisamide