DDInter461 DDInter255
Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Cytarabine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Cytarabine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) binds {v} (Gene) POLB
POLB {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) upregulates {v} (Gene) CCND3
CCND3 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Cytarabine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Cytarabine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) regulates {v} (Gene) MAMLD1
MAMLD1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Cytarabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Cytarabine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Cytarabine (Compound) upregulates C5 (Gene) and C5 (Gene) is upregulated by Busulfan (Compound)
Cytarabine (Compound) binds POLB (Gene) and POLB (Gene) is upregulated by Busulfan (Compound)
Cytarabine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Busulfan (Compound)
Cytarabine (Compound) binds DCK (Gene) and DCK (Gene) is downregulated by Busulfan (Compound)
Cytarabine (Compound) upregulates CCND3 (Gene) and CCND3 (Gene) is downregulated by Busulfan (Compound)
Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Cytarabine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) regulates MAMLD1 (Gene) and MAMLD1 (Gene) is upregulated by Busulfan (Compound)