DDInter82 DDInter1055
Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Amoxapine {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) causes {v} (Side Effect) Sensory loss
Sensory loss {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Chlordiazepoxide
Chlordiazepoxide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Lorazepam
Lorazepam {u} (Compound) downregulates {v} (Gene) PEG10
PEG10 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Zuclopenthixol
Zuclopenthixol {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Lorazepam
Lorazepam {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Zuclopenthixol
Zuclopenthixol {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Quetiapine
Quetiapine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Amoxapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Amoxapine (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Levofloxacin (Compound)
Amoxapine (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Amoxapine (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Amoxapine (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Amoxapine (Compound) resembles Lorazepam (Compound) and Lorazepam (Compound) downregulates PEG10 (Gene) and PEG10 (Gene) is downregulated by Levofloxacin (Compound)
Amoxapine (Compound) resembles Zuclopenthixol (Compound) and Zuclopenthixol (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Levofloxacin (Compound)
Amoxapine (Compound) resembles Lorazepam (Compound) and Lorazepam (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Amoxapine (Compound) resembles Zuclopenthixol (Compound) and Zuclopenthixol (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Amoxapine (Compound) resembles Quetiapine (Compound) and Quetiapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Amoxapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)