DDInter1619 DDInter1288
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals. Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market by Bayer in 1996.
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Niclosamide
Ropinirole {u} (Compound) upregulates {v} (Gene) GTF2A2
GTF2A2 {u} (Gene) is downregulated by {v} (Compound) Niclosamide
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Niclosamide
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Niclosamide
Ropinirole {u} (Compound) upregulates {v} (Gene) GTF2A2
GTF2A2 {u} (Gene) is regulated by {v} (Gene) SMAD3
SMAD3 {u} (Gene) is upregulated by {v} (Compound) Niclosamide
Ropinirole {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Diflunisal
Diflunisal {u} (Compound) resembles {v} (Compound) Niclosamide
Ropinirole {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Triclosan
Triclosan {u} (Compound) resembles {v} (Compound) Niclosamide
Ropinirole {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is upregulated by {v} (Compound) Niclosamide
Ropinirole {u} (Compound) upregulates {v} (Gene) GTF2A2
GTF2A2 {u} (Gene) regulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Niclosamide
Ropinirole {u} (Compound) causes {v} (Side Effect) Photosensitivity reaction
Photosensitivity reaction {u} (Side Effect) is caused by {v} (Compound) Diflunisal
Diflunisal {u} (Compound) resembles {v} (Compound) Niclosamide
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Niclosamide (Compound)
Ropinirole (Compound) upregulates GTF2A2 (Gene) and GTF2A2 (Gene) is downregulated by Niclosamide (Compound)
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Niclosamide (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Niclosamide
Ropinirole (Compound) upregulates GTF2A2 (Gene) and GTF2A2 (Gene) is regulated by SMAD3 (Gene) and SMAD3 (Gene) is upregulated by Niclosamide (Compound)
Ropinirole (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Diflunisal (Compound) and Diflunisal (Compound) resembles Niclosamide (Compound)
Ropinirole (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Triclosan (Compound) and Triclosan (Compound) resembles Niclosamide (Compound)
Ropinirole (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by GNPDA1 (Gene) and GNPDA1 (Gene) is upregulated by Niclosamide (Compound)
Ropinirole (Compound) upregulates GTF2A2 (Gene) and GTF2A2 (Gene) regulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Niclosamide (Compound)
Ropinirole (Compound) causes Photosensitivity reaction (Side Effect) and Photosensitivity reaction (Side Effect) is caused by Diflunisal (Compound) and Diflunisal (Compound) resembles Niclosamide (Compound)