DDInter381 DDInter305
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Carvedilol was granted FDA approval on 14 September 1995.
Cinacalcet {u} (Compound) resembles {v} (Compound) Demexiptiline
Demexiptiline {u} (Compound) resembles {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) causes {v} (Side Effect) Immune system disorder
Immune system disorder {u} (Side Effect) is caused by {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) resembles {v} (Compound) Demexiptiline
Demexiptiline {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Propafenone
Propafenone {u} (Compound) resembles {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Propafenone
Propafenone {u} (Compound) resembles {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) causes {v} (Side Effect) Immune system disorder
Immune system disorder {u} (Side Effect) is caused by {v} (Compound) Propafenone
Propafenone {u} (Compound) resembles {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) causes {v} (Side Effect) Gastrointestinal haemorrhage
Gastrointestinal haemorrhage {u} (Side Effect) is caused by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a minor interaction that can limit clinical effects when taken with {v} Carvedilol
Cinacalcet {u} (Compound) resembles {v} (Compound) Floctafenine
Floctafenine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Carvedilol
Cinacalcet {u} (Compound) causes {v} (Side Effect) Pain in extremity
Pain in extremity {u} (Side Effect) is caused by {v} (Compound) Octreotide
Octreotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carvedilol
Cinacalcet (Compound) resembles Demexiptiline (Compound) and Demexiptiline (Compound) resembles Carvedilol (Compound)
Cinacalcet (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Carvedilol (Compound)
Cinacalcet (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Carvedilol (Compound)
Cinacalcet (Compound) resembles Demexiptiline (Compound) and Demexiptiline (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Carvedilol (Compound)
Cinacalcet (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Propafenone (Compound) and Propafenone (Compound) resembles Carvedilol (Compound)
Cinacalcet (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propafenone (Compound) and Propafenone (Compound) resembles Carvedilol (Compound)
Cinacalcet (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Propafenone (Compound) and Propafenone (Compound) resembles Carvedilol (Compound)
Cinacalcet (Compound) causes Gastrointestinal haemorrhage (Side Effect) and Gastrointestinal haemorrhage (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Carvedilol
Cinacalcet (Compound) resembles Floctafenine (Compound) and Floctafenine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Carvedilol (Compound)
Cinacalcet (Compound) causes Pain in extremity (Side Effect) and Pain in extremity (Side Effect) is caused by Octreotide (Compound) and Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol