DDInter1528 DDInter1008
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Procyclidine {u} (Compound) resembles {v} (Compound) Trihexyphenidyl
Trihexyphenidyl {u} (Compound) causes {v} (Side Effect) Nervousness
Nervousness {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) resembles {v} (Compound) Biperiden
Biperiden {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) resembles {v} (Compound) Biperiden
Biperiden {u} (Compound) downregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) downregulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) resembles {v} (Compound) Biperiden
Biperiden {u} (Compound) downregulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) is downregulated by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is regulated by {v} (Gene) CYP1B1
CYP1B1 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Procyclidine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Procyclidine (Compound) resembles Trihexyphenidyl (Compound) and Trihexyphenidyl (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Ketoconazole (Compound)
Procyclidine (Compound) resembles Biperiden (Compound) and Biperiden (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ketoconazole (Compound)
Procyclidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Ketoconazole (Compound)
Procyclidine (Compound) resembles Biperiden (Compound) and Biperiden (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Ketoconazole (Compound)
Procyclidine (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) downregulates ALAS1 (Gene) and ALAS1 (Gene) is upregulated by Ketoconazole (Compound)
Procyclidine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is regulated by DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Ketoconazole (Compound)
Procyclidine (Compound) resembles Biperiden (Compound) and Biperiden (Compound) downregulates PPP2R3C (Gene) and PPP2R3C (Gene) is downregulated by Ketoconazole (Compound)
Procyclidine (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is regulated by CYP1B1 (Gene) and CYP1B1 (Gene) is bound by Ketoconazole (Compound)
Procyclidine (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ketoconazole (Compound)
Procyclidine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Ketoconazole (Compound)