DDInter596 DDInter806
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Doxorubicin {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Ganciclovir
Doxorubicin {u} (Compound) downregulates {v} (Gene) CANT1
CANT1 {u} (Gene) is downregulated by {v} (Compound) Ganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Creatinine increased
Creatinine increased {u} (Side Effect) is caused by {v} (Compound) Ganciclovir
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Doxorubicin {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Doxorubicin {u} (Compound) downregulates {v} (Gene) CANT1
CANT1 {u} (Gene) is regulated by {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Ganciclovir
Doxorubicin {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) regulates {v} (Gene) CANT1
CANT1 {u} (Gene) is downregulated by {v} (Compound) Ganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Creatinine increased
Creatinine increased {u} (Side Effect) is caused by {v} (Compound) Valaciclovir
Valaciclovir {u} (Compound) resembles {v} (Compound) Ganciclovir
Doxorubicin {u} (Compound) causes {v} (Side Effect) Injection site infection
Injection site infection {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Doxorubicin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Ganciclovir (Compound)
Doxorubicin (Compound) downregulates CANT1 (Gene) and CANT1 (Gene) is downregulated by Ganciclovir (Compound)
Doxorubicin (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Ganciclovir (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir
Doxorubicin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir
Doxorubicin (Compound) downregulates CANT1 (Gene) and CANT1 (Gene) is regulated by CDC25B (Gene) and CDC25B (Gene) is downregulated by Ganciclovir (Compound)
Doxorubicin (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) regulates CANT1 (Gene) and CANT1 (Gene) is downregulated by Ganciclovir (Compound)
Doxorubicin (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Valaciclovir (Compound) and Valaciclovir (Compound) resembles Ganciclovir (Compound)
Doxorubicin (Compound) causes Injection site infection (Side Effect) and Injection site infection (Side Effect) is caused by Capecitabine (Compound) and Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir