DDInter458 DDInter1837
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has estrogenic (agonist) activity on the cardiovascular system and on bone tissue and it has weak estrogenic effects on uterine tissue, however, it also has antiestrogenic (estrogen-antagonist) activity on breast tissue.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLT1B
GOLT1B {u} (Gene) is downregulated by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Toremifene
Cyclosporine {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Toremifene
Cyclosporine {u} (Compound) upregulates {v} (Gene) ADGRG1
ADGRG1 {u} (Gene) regulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Toremifene
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Toremifene
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Toremifene (Compound)
Cyclosporine (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Toremifene (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Toremifene (Compound)
Cyclosporine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Toremifene (Compound)
Cyclosporine (Compound) upregulates GOLT1B (Gene) and GOLT1B (Gene) is downregulated by Toremifene (Compound)
Cyclosporine (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Toremifene (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clomifene (Compound) and Clomifene (Compound) resembles Toremifene (Compound)
Cyclosporine (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Clomifene (Compound) and Clomifene (Compound) resembles Toremifene (Compound)
Cyclosporine (Compound) upregulates ADGRG1 (Gene) and ADGRG1 (Gene) regulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Toremifene (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Clomifene (Compound) and Clomifene (Compound) resembles Toremifene (Compound)