DDInter1642 DDInter1939
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the treatment of NSCLC . It is a third-generation vinca alkaloid. The introduction of third-generation drugs (vinorelbine, gemcitabine, taxanes) in platinum combination improved survival of patients with advanced NSCLC, with very similar results from the various drugs. Treatment toxicities are considerable in the combination treatment setting . A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations. It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug .
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Vinorelbine {u} (Compound) treats {v} (Disease) hematologic cancer
Vinorelbine {u} (Compound) binds {v} (Gene) TUBB4B
Vinorelbine {u} (Compound) upregulates {v} (Gene) LAMC2
Vinorelbine {u} (Compound) is included by {v} (Pharmacologic Class) Vinca Alkaloids
Vinorelbine {u} (Compound) downregulates {v} (Gene) IARS2
Vinorelbine {u} (Compound) causes {v} (Side Effect) Angina pectoris
Vinorelbine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Vinorelbine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Vinorelbine (Compound) resembles Vincristine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Vinorelbine (Compound) treats hematologic cancer (Disease)
Vinorelbine (Compound) binds TUBB4B (Gene)
Vinorelbine (Compound) upregulates LAMC2 (Gene)
Vinorelbine (Compound) is included by Vinca Alkaloids (Pharmacologic Class)
Vinorelbine (Compound) downregulates IARS2 (Gene)
Vinorelbine (Compound) causes Angina pectoris (Side Effect)
Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Modafinil
Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin