DDInter1840 DDInter1193
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US.
Trabectedin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Eplerenone
Eplerenone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) binds {v} (Gene) SRC
SRC {u} (Gene) interacts with {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Danazol
Danazol {u} (Compound) resembles {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methyltestosterone
Trabectedin {u} (Compound) binds {v} (Gene) SRC
SRC {u} (Gene) is upregulated by {v} (Compound) Mestranol
Mestranol {u} (Compound) resembles {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Danazol
Danazol {u} (Compound) resembles {v} (Compound) Methyltestosterone
Trabectedin {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is palliated by {v} (Compound) Methyltestosterone
Trabectedin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methyltestosterone (Compound)
Trabectedin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Methyltestosterone (Compound)
Trabectedin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Eplerenone (Compound) and Eplerenone (Compound) resembles Methyltestosterone (Compound)
Trabectedin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Methyltestosterone (Compound)
Trabectedin (Compound) binds SRC (Gene) and SRC (Gene) interacts with AR (Gene) and AR (Gene) is bound by Methyltestosterone (Compound)
Trabectedin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Danazol (Compound) and Danazol (Compound) resembles Methyltestosterone (Compound)
Trabectedin (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone
Trabectedin (Compound) binds SRC (Gene) and SRC (Gene) is upregulated by Mestranol (Compound) and Mestranol (Compound) resembles Methyltestosterone (Compound)
Trabectedin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Danazol (Compound) and Danazol (Compound) resembles Methyltestosterone (Compound)
Trabectedin (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is palliated by Methyltestosterone (Compound)