DDInter1253 DDInter1747
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as active as Δ⁹-THC. Nabilone is approved by the FDA for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction with cannabinoid receptors that are
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Nabilone {u} (Compound) resembles {v} (Compound) Dronabinol
Nabilone {u} (Compound) binds {v} (Gene) CNR2
Nabilone {u} (Compound) is included by {v} (Pharmacologic Class) Cannabinoids
Nabilone {u} (Compound) causes {v} (Side Effect) Lightheadedness
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Nabilone {u} may lead to a major life threatening interaction when taken with {v} Levacetylmethadol
Nabilone (Compound) resembles Dronabinol (Compound)
Nabilone (Compound) binds CNR2 (Gene)
Nabilone (Compound) is included by Cannabinoids (Pharmacologic Class)
Nabilone (Compound) causes Lightheadedness (Side Effect)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Nabilone may lead to a major life threatening interaction when taken with Levacetylmethadol