DDInter1537 DDInter535
Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Propiomazine {u} (Compound) resembles {v} (Compound) Promazine
Promazine {u} (Compound) downregulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Promethazine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Promethazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Fluphenazine
Fluphenazine {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Fluphenazine
Fluphenazine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Propericiazine
Propericiazine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} (Compound) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Chlorpromazine
Chlorpromazine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Propiomazine {u} (Compound) resembles {v} (Compound) Alimemazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Propiomazine (Compound) resembles Promazine (Compound) and Promazine (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Diazoxide (Compound)
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Diazoxide (Compound)
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Propiomazine (Compound) resembles Fluphenazine (Compound) and Fluphenazine (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Propiomazine (Compound) resembles Fluphenazine (Compound) and Fluphenazine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Propiomazine (Compound) resembles Propericiazine (Compound) and Propericiazine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Diazoxide (Compound)
Propiomazine (Compound) resembles Thioridazine (Compound) and Thioridazine (Compound) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Diazoxide (Compound)
Propiomazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Propiomazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Diazoxide (Compound)
Propiomazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)