DDInter998 DDInter690
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Ivermectin {u} (Compound) downregulates {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Ivermectin {u} (Compound) downregulates {v} (Gene) NUSAP1
NUSAP1 {u} (Gene) is regulated by {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Ethanol
Ivermectin {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Ethanol
Ivermectin {u} (Compound) binds {v} (Gene) GABRB3
GABRB3 {u} (Gene) interacts with {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Ethanol
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Ivermectin (Compound) downregulates PGRMC1 (Gene) and PGRMC1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Ivermectin (Compound) downregulates NUSAP1 (Gene) and NUSAP1 (Gene) is regulated by CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Ethanol (Compound)
Ivermectin (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Ethanol (Compound)
Ivermectin (Compound) binds GABRB3 (Gene) and GABRB3 (Gene) interacts with GABRA1 (Gene) and GABRA1 (Gene) is bound by Ethanol (Compound)