DDInter392 DDInter298
An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Cladribine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Carboplatin
Cladribine {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Cladribine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Cisplatin
Cisplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cladribine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is associated with {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Capecitabine
Capecitabine {u} (Compound) causes {v} (Side Effect) Venous thrombosis
Venous thrombosis {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Cisplatin
Cisplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Cladribine {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is associated with {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cladribine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cladribine {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Carboplatin (Compound)
Cladribine (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Carboplatin (Compound)
Cladribine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Carboplatin (Compound)
Cladribine may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Cladribine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is associated with esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Cladribine may lead to a major life threatening interaction when taken with Capecitabine and Capecitabine (Compound) causes Venous thrombosis (Side Effect) and Venous thrombosis (Side Effect) is caused by Carboplatin (Compound)
Cladribine may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Carboplatin (Compound)
Cladribine (Compound) downregulates MYC (Gene) and MYC (Gene) is associated with esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Cladribine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is downregulated by breast cancer (Disease) and CXCL2 (Disease) associated with breast cancer (Gene) and breast cancer (Disease) is treated by Carboplatin (Compound)
Cladribine (Compound) downregulates MYC (Gene) and MYC (Gene) is downregulated by breast cancer (Disease) and MYC (Disease) associated with breast cancer (Gene) and breast cancer (Disease) is treated by Carboplatin (Compound)