DDInter1834 DDInter1535
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Topiramate {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Propantheline
Topiramate {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Propantheline
Topiramate {u} (Compound) causes {v} (Side Effect) Accommodation disorder
Accommodation disorder {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Topiramate {u} (Compound) causes {v} (Side Effect) Anhidrosis
Anhidrosis {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Topiramate {u} (Compound) causes {v} (Side Effect) Dermatitis atopic
Dermatitis atopic {u} (Side Effect) is caused by {v} (Compound) Acetaminophen
Acetaminophen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Propantheline
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Propantheline
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Propantheline
Topiramate {u} (Compound) causes {v} (Side Effect) Anhidrosis
Anhidrosis {u} (Side Effect) is caused by {v} (Compound) Zonisamide
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Propantheline
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) regulates {v} (Gene) RRM2
RRM2 {u} (Gene) is downregulated by {v} (Compound) Propantheline
Topiramate {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is associated with {v} (Gene) COG2
COG2 {u} (Gene) is downregulated by {v} (Compound) Propantheline
Topiramate (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Topiramate (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Propantheline
Topiramate (Compound) causes Accommodation disorder (Side Effect) and Accommodation disorder (Side Effect) is caused by Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline
Topiramate (Compound) causes Anhidrosis (Side Effect) and Anhidrosis (Side Effect) is caused by Atropine (Compound) and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline
Topiramate (Compound) causes Dermatitis atopic (Side Effect) and Dermatitis atopic (Side Effect) is caused by Acetaminophen (Compound) and Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Propantheline
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Topiramate (Compound) causes Anhidrosis (Side Effect) and Anhidrosis (Side Effect) is caused by Zonisamide (Compound) and Zonisamide may lead to a major life threatening interaction when taken with Propantheline
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) regulates RRM2 (Gene) and RRM2 (Gene) is downregulated by Propantheline (Compound)
Topiramate (Compound) treats obesity (Disease) and obesity (Disease) is associated with COG2 (Gene) and COG2 (Gene) is downregulated by Propantheline (Compound)