DDInter1864 DDInter1654
Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease, TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and tolerant to [penicillamine]. TETA has been investigated in clinical trials for the treatment of heart failure in patients with diabetes.[A18804,A19332,A19333,A19334,A19335]
Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species [FDA Label]
Triethylenetetramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zinc gluconate
Triethylenetetramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcium gluconate
Triethylenetetramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium oxide
Triethylenetetramine may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Triethylenetetramine may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Triethylenetetramine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide