DDInter1650 DDInter899
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Secobarbital {u} (Compound) resembles {v} (Compound) Amobarbital
Secobarbital {u} (Compound) resembles {v} (Compound) Thiopental
Secobarbital {u} (Compound) binds {v} (Gene) GRIK2
Secobarbital {u} (Compound) causes {v} (Side Effect) Hyperkinesia
Secobarbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Secobarbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Secobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Secobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Secobarbital {u} may lead to a major life threatening interaction when taken with {v} Morphine
Secobarbital {u} may lead to a major life threatening interaction when taken with {v} Hemin
Secobarbital (Compound) resembles Amobarbital (Compound)
Secobarbital (Compound) resembles Thiopental (Compound)
Secobarbital (Compound) binds GRIK2 (Gene)
Secobarbital (Compound) causes Hyperkinesia (Side Effect)
Secobarbital may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Secobarbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Theophylline
Secobarbital may lead to a major life threatening interaction when taken with Morphine
Secobarbital may lead to a major life threatening interaction when taken with Hemin