DDInter458 DDInter1490
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Polythiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) PIN1
PIN1 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Dicyclomine
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polythiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TES
TES {u} (Gene) is downregulated by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Saxagliptin
Saxagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polythiazide
Cyclosporine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Polythiazide (Compound)
Cyclosporine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Cyclosporine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Cyclosporine (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Polythiazide (Compound)
Cyclosporine (Compound) downregulates PIN1 (Gene) and PIN1 (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide
Cyclosporine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide
Cyclosporine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Dicyclomine (Compound) and Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Polythiazide
Cyclosporine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide
Cyclosporine (Compound) upregulates TES (Gene) and TES (Gene) is downregulated by Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Cyclosporine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Saxagliptin (Compound) and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide