DDInter1620 DDInter909
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy".. The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment can be tailored specifically to the unique cancer genetics of each patient. Imatinib was approved on February 1st ,2001 by the FDA and November 7th, 2001 by the EMA; however, its European approval has been withdrawn in October 2023.[A263036,L49746,L49751]
Ropivacaine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Imatinib
Ropivacaine {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Imatinib
Ropivacaine {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Imatinib
Ropivacaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Imatinib
Ropivacaine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Imatinib
Ropivacaine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Meclizine
Meclizine {u} (Compound) resembles {v} (Compound) Imatinib
Ropivacaine {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is regulated by {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Imatinib
Ropivacaine {u} (Compound) causes {v} (Side Effect) Cardiac disorder
Cardiac disorder {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Imatinib
Ropivacaine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Meclizine
Meclizine {u} (Compound) resembles {v} (Compound) Imatinib
Ropivacaine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Imatinib
Ropivacaine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Imatinib (Compound)
Ropivacaine (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Imatinib (Compound)
Ropivacaine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Imatinib (Compound)
Ropivacaine (Compound) resembles Lidocaine (Compound) and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib
Ropivacaine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Imatinib
Ropivacaine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Meclizine (Compound) and Meclizine (Compound) resembles Imatinib (Compound)
Ropivacaine (Compound) upregulates MAL (Gene) and MAL (Gene) is regulated by CA12 (Gene) and CA12 (Gene) is bound by Imatinib (Compound)
Ropivacaine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a minor interaction that can limit clinical effects when taken with Imatinib
Ropivacaine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Meclizine (Compound) and Meclizine (Compound) resembles Imatinib (Compound)
Ropivacaine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Imatinib