DDInter1233 DDInter1400
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Mitotane {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Mitotane {u} (Compound) downregulates {v} (Gene) DNMT3A
DNMT3A {u} (Gene) is downregulated by {v} (Compound) Pazopanib
Mitotane {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Mitotane {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is associated with {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Pazopanib
Mitotane {u} (Compound) downregulates {v} (Gene) DNMT3A
DNMT3A {u} (Gene) regulates {v} (Gene) CRIP1
CRIP1 {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is regulated by {v} (Gene) IL1R2
IL1R2 {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Mitotane {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) regulates {v} (Gene) LYN
LYN {u} (Gene) is bound by {v} (Compound) Pazopanib
Mitotane {u} (Compound) downregulates {v} (Gene) ARNT2
ARNT2 {u} (Gene) is downregulated by {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Pazopanib
Mitotane {u} (Compound) downregulates {v} (Gene) ZNF395
ZNF395 {u} (Gene) is regulated by {v} (Gene) SH2B3
SH2B3 {u} (Gene) is bound by {v} (Compound) Pazopanib
Mitotane {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pazopanib
Mitotane (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Pazopanib (Compound)
Mitotane (Compound) downregulates DNMT3A (Gene) and DNMT3A (Gene) is downregulated by Pazopanib (Compound)
Mitotane (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Mitotane (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is associated with kidney cancer (Disease) and kidney cancer (Disease) is treated by Pazopanib (Compound)
Mitotane (Compound) downregulates DNMT3A (Gene) and DNMT3A (Gene) regulates CRIP1 (Gene) and CRIP1 (Gene) is upregulated by Pazopanib (Compound)
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is regulated by IL1R2 (Gene) and IL1R2 (Gene) is upregulated by Pazopanib (Compound)
Mitotane (Compound) downregulates NVL (Gene) and NVL (Gene) regulates LYN (Gene) and LYN (Gene) is bound by Pazopanib (Compound)
Mitotane (Compound) downregulates ARNT2 (Gene) and ARNT2 (Gene) is downregulated by kidney cancer (Disease) and kidney cancer (Disease) is treated by Pazopanib (Compound)
Mitotane (Compound) downregulates ZNF395 (Gene) and ZNF395 (Gene) is regulated by SH2B3 (Gene) and SH2B3 (Gene) is bound by Pazopanib (Compound)
Mitotane (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Pazopanib