DDInter413 DDInter1662
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease, It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin. Clopidogrel was granted FDA approval on 17 November 1997.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Clopidogrel {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) downregulates {v} (Gene) VAT1
VAT1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Clopidogrel {u} (Compound) downregulates {v} (Gene) VAT1
VAT1 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Clopidogrel {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Clopidogrel {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Clopidogrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Clopidogrel (Compound) downregulates VAT1 (Gene) and VAT1 (Gene) is upregulated by Sertraline (Compound)
Clopidogrel (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Sertraline (Compound)
Clopidogrel (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Sertraline (Compound)
Clopidogrel (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Clopidogrel (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Clopidogrel (Compound) downregulates VAT1 (Gene) and VAT1 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Sertraline (Compound)
Clopidogrel (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Clopidogrel (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Clopidogrel (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)