DDInter1042 DDInter901
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).
Ibutilide {u} (Compound) resembles {v} (Compound) Dronedarone
Ibutilide {u} (Compound) binds {v} (Gene) KCNH7
Ibutilide {u} (Compound) causes {v} (Side Effect) Bradycardia
Ibutilide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Ibutilide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Ibutilide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Ibutilide {u} may lead to a major life threatening interaction when taken with {v} Mefloquine
Ibutilide {u} may lead to a major life threatening interaction when taken with {v} Anagrelide
Ibutilide (Compound) resembles Dronedarone (Compound)
Ibutilide (Compound) binds KCNH7 (Gene)
Ibutilide (Compound) causes Bradycardia (Side Effect)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine
Ibutilide may lead to a major life threatening interaction when taken with Mefloquine
Ibutilide may lead to a major life threatening interaction when taken with Anagrelide