DDInter1158 DDInter1135
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Mesalazine {u} (Compound) binds {v} (Gene) ALOX5
ALOX5 {u} (Gene) is bound by {v} (Compound) Meclofenamic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Meclofenamic acid
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Mesalazine {u} (Compound) binds {v} (Gene) ALOX5
ALOX5 {u} (Gene) is bound by {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Meclofenamic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Systemic lupus erythematosus
Systemic lupus erythematosus {u} (Side Effect) is caused by {v} (Compound) Triamcinolone
Triamcinolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Erythema nodosum
Erythema nodosum {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Meclofenamic acid
Mesalazine (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) resembles Meclofenamic acid (Compound)
Mesalazine (Compound) binds ALOX5 (Gene) and ALOX5 (Gene) is bound by Meclofenamic acid (Compound)
Mesalazine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Meclofenamic acid (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Mesalazine (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Meclofenamic acid (Compound)
Mesalazine (Compound) binds ALOX5 (Gene) and ALOX5 (Gene) is bound by Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Salicylic acid (Compound) and Salicylic acid (Compound) resembles Meclofenamic acid (Compound)
Mesalazine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Salsalate (Compound) and Salsalate (Compound) resembles Meclofenamic acid (Compound)
Mesalazine (Compound) causes Systemic lupus erythematosus (Side Effect) and Systemic lupus erythematosus (Side Effect) is caused by Triamcinolone (Compound) and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Mesalazine (Compound) causes Erythema nodosum (Side Effect) and Erythema nodosum (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Meclofenamic acid