DDInter1031 DDInter1258
Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients. Treatment options for chronic Hepatitis C have advanced significantly since 2011, with the development of Direct Acting Antivirals (DAAs) such as ledipasvir. More specifically, ledipasvir is an inhibitor of the Hepatitis C Virus (HCV) Non-Structural Protein 5A (NS5A), which is required for viral RNA replication and assembly of HCV virions. Although its exact mechanism of action is unknown, it is postulated to prevent hyperphosphorylation of NS5A which is required
Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation.
Naldemedine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Naldemedine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mifepristone
Naldemedine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Istradefylline
Naldemedine {u} may lead to a major life threatening interaction when taken with {v} Phenobarbital
Naldemedine {u} may lead to a major life threatening interaction when taken with {v} Apalutamide
Naldemedine may cause a minor interaction that can limit clinical effects when taken with Modafinil
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Istradefylline
Naldemedine may lead to a major life threatening interaction when taken with Phenobarbital
Naldemedine may lead to a major life threatening interaction when taken with Apalutamide