DDInter458 DDInter557
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Injury
Injury {u} (Side Effect) is caused by {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is regulated by {v} (Gene) SHB
SHB {u} (Gene) is downregulated by {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) regulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) is downregulated by {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC45
CDC45 {u} (Gene) is downregulated by {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) downregulates {v} (Gene) LBR
LBR {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) IPO13
IPO13 {u} (Gene) is downregulated by {v} (Compound) Dihydroergotamine
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dihydroergotamine (Compound)
Cyclosporine (Compound) causes Injury (Side Effect) and Injury (Side Effect) is caused by Dihydroergotamine (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ergotamine (Compound) and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Cyclosporine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Bromocriptine (Compound) and Bromocriptine (Compound) resembles Dihydroergotamine (Compound)
Cyclosporine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Bromocriptine (Compound) and Bromocriptine (Compound) resembles Dihydroergotamine (Compound)
Cyclosporine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is regulated by SHB (Gene) and SHB (Gene) is downregulated by Dihydroergotamine (Compound)
Cyclosporine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) regulates CTNND1 (Gene) and CTNND1 (Gene) is downregulated by Dihydroergotamine (Compound)
Cyclosporine (Compound) downregulates CDC45 (Gene) and CDC45 (Gene) is downregulated by Bromocriptine (Compound) and Bromocriptine (Compound) resembles Dihydroergotamine (Compound)
Cyclosporine (Compound) downregulates LBR (Gene) and LBR (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Dihydroergotamine (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by IPO13 (Gene) and IPO13 (Gene) is downregulated by Dihydroergotamine (Compound)