DDInter130 DDInter1545
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review
Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described in dogs in 1927.
Atenolol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Pseudoephedrine
Atenolol {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Pseudoephedrine
Atenolol {u} (Compound) resembles {v} (Compound) Bisoprolol
Bisoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Atenolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Atenolol {u} (Compound) resembles {v} (Compound) Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Atenolol {u} (Compound) resembles {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Atenolol {u} (Compound) resembles {v} (Compound) Procarbazine
Procarbazine {u} may lead to a major life threatening interaction when taken with {v} Pseudoephedrine
Atenolol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) interacts with {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Pseudoephedrine
Atenolol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Ephedrine
Ephedrine {u} (Compound) resembles {v} (Compound) Pseudoephedrine
Atenolol {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Atenolol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Pseudoephedrine (Compound)
Atenolol (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Pseudoephedrine (Compound)
Atenolol (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Atenolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Atenolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Atenolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Atenolol (Compound) resembles Procarbazine (Compound) and Procarbazine may lead to a major life threatening interaction when taken with Pseudoephedrine
Atenolol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) interacts with ADRA2A (Gene) and ADRA2A (Gene) is bound by Pseudoephedrine (Compound)
Atenolol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is bound by Ephedrine (Compound) and Ephedrine (Compound) resembles Pseudoephedrine (Compound)
Atenolol (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Phentermine (Compound) and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine