DDInter742 DDInter178
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Floxuridine {u} (Compound) resembles {v} (Compound) Trifluridine
Floxuridine {u} (Compound) resembles {v} (Compound) Emtricitabine
Floxuridine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Floxuridine {u} (Compound) treats {v} (Disease) stomach cancer
Floxuridine {u} (Compound) binds {v} (Gene) TYMS
Floxuridine {u} (Compound) upregulates {v} (Gene) PMAIP1
Floxuridine {u} (Compound) is included by {v} (Pharmacologic Class) Deoxyuridine
Floxuridine {u} (Compound) downregulates {v} (Gene) PPP2R3C
Floxuridine {u} (Compound) causes {v} (Side Effect) Myocardial ischaemia
Floxuridine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Floxuridine (Compound) resembles Trifluridine (Compound)
Floxuridine (Compound) resembles Emtricitabine (Compound)
Floxuridine may lead to a major life threatening interaction when taken with Cladribine
Floxuridine (Compound) treats stomach cancer (Disease)
Floxuridine (Compound) binds TYMS (Gene)
Floxuridine (Compound) upregulates PMAIP1 (Gene)
Floxuridine (Compound) is included by Deoxyuridine (Pharmacologic Class)
Floxuridine (Compound) downregulates PPP2R3C (Gene)
Floxuridine (Compound) causes Myocardial ischaemia (Side Effect)
Floxuridine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin