DDInter416 DDInter439
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.[L5605, T475] The conjugated estrogen product contains a mix of estrogen from which about 50% is represented by estrone sulfate followed by 25% of equilin sulfate, 15% of 17-alpha-dehydroequilenin sulfate, 3% of equilenin sulfate, 5% of 17-alpha and 17-beta-dihydroequilenin sulfate, 2% of 17-alpha-estradiolsulfate and 3% of 17-beta-estradiolsulfate. It also presents a large number of unidentified molecules with weak estrogenic activity as well as non-human molecules when it is obtained from pregnant mares urine. The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions. However, until 1986 official clinical trials were performed and this product was determined to be effective for the treatment of osteoporosis. The currently approved product of conjugated estrogens was developed by Wyeth Ayerst and FDA approved in 2003.
Clotrimazole {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) causes {v} (Side Effect) Cystitis noninfective
Cystitis noninfective {u} (Side Effect) is caused by {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Metyrapone
Metyrapone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conjugated estrogens
Clotrimazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Estrone sulfate
Estrone sulfate {u} (Compound) resembles {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) resembles {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) causes {v} (Side Effect) Cystitis noninfective
Cystitis noninfective {u} (Side Effect) is caused by {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) resembles {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Estrone sulfate
Estrone sulfate {u} (Compound) resembles {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Exemestane
Exemestane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conjugated estrogens
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Conjugated estrogens
Clotrimazole {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) regulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is downregulated by {v} (Compound) Conjugated estrogens
Clotrimazole (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Conjugated estrogens (Compound)
Clotrimazole (Compound) causes Cystitis noninfective (Side Effect) and Cystitis noninfective (Side Effect) is caused by Conjugated estrogens (Compound)
Clotrimazole (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Metyrapone (Compound) and Metyrapone may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens
Clotrimazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Estrone sulfate (Compound) and Estrone sulfate (Compound) resembles Conjugated estrogens (Compound)
Clotrimazole (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Ethinylestradiol (Compound) and Ethinylestradiol (Compound) resembles Conjugated estrogens (Compound)
Clotrimazole (Compound) causes Cystitis noninfective (Side Effect) and Cystitis noninfective (Side Effect) is caused by Ethinylestradiol (Compound) and Ethinylestradiol (Compound) resembles Conjugated estrogens (Compound)
Clotrimazole (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Estrone sulfate (Compound) and Estrone sulfate (Compound) resembles Conjugated estrogens (Compound)
Clotrimazole (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Exemestane (Compound) and Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Conjugated estrogens (Compound)
Clotrimazole (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) regulates CHIC2 (Gene) and CHIC2 (Gene) is downregulated by Conjugated estrogens (Compound)