DDInter854 DDInter1376
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Halothane {u} (Compound) resembles {v} (Compound) Isoflurane
Halothane {u} (Compound) binds {v} (Gene) GRIN2A
Halothane {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prasugrel
Halothane {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Halothane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Halothane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Degarelix
Halothane {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Halothane {u} may lead to a major life threatening interaction when taken with {v} Cabozantinib
Halothane (Compound) resembles Isoflurane (Compound)
Halothane (Compound) binds GRIN2A (Gene)
Halothane may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Halothane may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Degarelix
Halothane may lead to a major life threatening interaction when taken with Cisapride
Halothane may lead to a major life threatening interaction when taken with Cabozantinib