DDInter202 DDInter1747
Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Bexarotene {u} (Compound) resembles {v} (Compound) Tamibarotene
Bexarotene {u} (Compound) treats {v} (Disease) hematologic cancer
Bexarotene {u} (Compound) binds {v} (Gene) RXRG
Bexarotene {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Bexarotene {u} (Compound) causes {v} (Side Effect) Hypocholesterolaemia
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Griseofulvin
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palifermin
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amlodipine
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Cytarabine
Bexarotene (Compound) resembles Tamibarotene (Compound)
Bexarotene (Compound) treats hematologic cancer (Disease)
Bexarotene (Compound) binds RXRG (Gene)
Bexarotene (Compound) is included by Retinoids (Pharmacologic Class)
Bexarotene (Compound) causes Hypocholesterolaemia (Side Effect)
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Griseofulvin
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Palifermin
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine
Bexarotene may lead to a major life threatening interaction when taken with Cytarabine