DDInter1064 DDInter278
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T<sub>4</sub> (tetraiodothyronine or thyroxine) and T<sub>3</sub> (triiodothyronine or ), resulting in diminished down-stream effects of these hormones. Without sufficient quantities of circulating thyroid hormones, symptoms of hypothyroidism begin to develop such as fatigue, increased heart rate, depression, dry skin and hair, muscle cramps, constipation, weight gain, memory impairment, and poor tolerance to cold temperatures.[F4636,A35722] In response to Thyroid Stimulating Hormone (TSH) release by
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Levothyroxine {u} (Compound) resembles {v} (Compound) Dextrothyroxine
Levothyroxine {u} (Compound) treats {v} (Disease) hypothyroidism
Levothyroxine {u} (Compound) binds {v} (Gene) CYP2C8
Levothyroxine {u} (Compound) upregulates {v} (Gene) AGR2
Levothyroxine {u} (Compound) is included by {v} (Pharmacologic Class) Thyroxine
Levothyroxine {u} (Compound) downregulates {v} (Gene) FHL2
Levothyroxine {u} (Compound) causes {v} (Side Effect) Hypoglycaemia
Levothyroxine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Levothyroxine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoprolol
Levothyroxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentobarbital
Levothyroxine (Compound) resembles Dextrothyroxine (Compound)
Levothyroxine (Compound) treats hypothyroidism (Disease)
Levothyroxine (Compound) binds CYP2C8 (Gene)
Levothyroxine (Compound) upregulates AGR2 (Gene)
Levothyroxine (Compound) is included by Thyroxine (Pharmacologic Class)
Levothyroxine (Compound) downregulates FHL2 (Gene)
Levothyroxine (Compound) causes Hypoglycaemia (Side Effect)
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital