DDInter998 DDInter1951
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) NR1H4
NR1H4 {u} (Gene) is bound by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Ezetimibe
Ezetimibe {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) GABRB3
GABRB3 {u} (Gene) is bound by {v} (Compound) Ethchlorvynol
Ethchlorvynol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Ivermectin {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Ivermectin {u} (Compound) binds {v} (Gene) GABRB3
GABRB3 {u} (Gene) is bound by {v} (Compound) Methohexital
Methohexital {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Ivermectin {u} (Compound) upregulates {v} (Gene) TRIB1
TRIB1 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Warfarin (Compound)
Ivermectin (Compound) binds NR1H4 (Gene) and NR1H4 (Gene) is bound by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Warfarin (Compound)
Ivermectin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Warfarin
Ivermectin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Ezetimibe (Compound) and Ezetimibe may cause a minor interaction that can limit clinical effects when taken with Warfarin
Ivermectin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenytoin (Compound) and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Ivermectin (Compound) binds GABRB3 (Gene) and GABRB3 (Gene) is bound by Ethchlorvynol (Compound) and Ethchlorvynol may cause a minor interaction that can limit clinical effects when taken with Warfarin
Ivermectin (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Warfarin
Ivermectin (Compound) binds GABRB3 (Gene) and GABRB3 (Gene) is bound by Methohexital (Compound) and Methohexital may lead to a major life threatening interaction when taken with Warfarin
Ivermectin (Compound) upregulates TRIB1 (Gene) and TRIB1 (Gene) is upregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Warfarin