DDInter1357 DDInter1840
A synthetic hormone with anabolic and androgenic properties.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Oxandrolone {u} (Compound) causes {v} (Side Effect) Haemoglobin
Haemoglobin {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Oxandrolone {u} (Compound) binds {v} (Gene) AR
AR {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Oxandrolone {u} (Compound) downregulates {v} (Gene) IGFBP2
IGFBP2 {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Oxandrolone {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Nateglinide {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Torasemide
Torasemide {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Oxandrolone {u} (Compound) resembles {v} (Compound) Allylestrenol
Allylestrenol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trabectedin
Oxandrolone {u} (Compound) resembles {v} (Compound) Spironolactone
Spironolactone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Torasemide
Torasemide {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Nateglinide {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Oxandrolone (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Trabectedin (Compound)
Oxandrolone (Compound) binds AR (Gene) and AR (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Oxandrolone (Compound) downregulates IGFBP2 (Gene) and IGFBP2 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Oxandrolone (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Torasemide and Torasemide (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)
Oxandrolone (Compound) resembles Allylestrenol (Compound) and Allylestrenol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trabectedin (Compound)
Oxandrolone (Compound) resembles Spironolactone (Compound) and Spironolactone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Trabectedin (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Torasemide and Torasemide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Trabectedin (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Trabectedin (Compound)