DDInter241 DDInter1055
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239]
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Bromfenac {u} (Compound) causes {v} (Side Effect) Asthma
Asthma {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) causes {v} (Side Effect) Asthma
Asthma {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) resembles {v} (Compound) Lumiracoxib
Lumiracoxib {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) causes {v} (Side Effect) Asthma
Asthma {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) resembles {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) resembles {v} (Compound) Aminohippurate
Aminohippurate {u} (Compound) downregulates {v} (Gene) TES
TES {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Bromfenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Diclofenac {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Bromfenac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Bromfenac (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Levofloxacin (Compound)
Bromfenac (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Bromfenac (Compound) resembles Lumiracoxib (Compound) and Lumiracoxib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Bromfenac (Compound) causes Asthma (Side Effect) and Asthma (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Bromfenac (Compound) resembles Suprofen (Compound) and Suprofen (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)
Bromfenac (Compound) resembles Suprofen (Compound) and Suprofen (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Bromfenac (Compound) resembles Ketoprofen (Compound) and Ketoprofen (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Bromfenac (Compound) resembles Aminohippurate (Compound) and Aminohippurate (Compound) downregulates TES (Gene) and TES (Gene) is downregulated by Levofloxacin (Compound)
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Bromfenac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by PRKACA (Gene) and PRKACA (Gene) is downregulated by Levofloxacin (Compound)