DDInter1123 DDInter1783
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml. Other formulations of tetracycline continue to be used.
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Diclofenamide
Diclofenamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Mannitol {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Diclofenamide
Diclofenamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Methazolamide
Methazolamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Mannitol {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Triamterene
Triamterene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracycline
Mannitol {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracycline
Mannitol {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Amiloride
Amiloride {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mefloquine
Mefloquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Mannitol {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Bismuth subsalicylate
Bismuth subsalicylate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracycline
Mannitol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Lomitapide
Lomitapide {u} may lead to a major life threatening interaction when taken with {v} Tetracycline
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Diclofenamide (Compound) and Diclofenamide may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mannitol (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Diclofenamide (Compound) and Diclofenamide may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Methazolamide (Compound) and Methazolamide may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mannitol (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Triamterene (Compound) and Triamterene may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline
Mannitol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Mycophenolate mofetil (Compound) and Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline
Mannitol (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Amiloride (Compound) and Amiloride may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mefloquine (Compound) and Mefloquine may cause a minor interaction that can limit clinical effects when taken with Tetracycline
Mannitol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Bismuth subsalicylate (Compound) and Bismuth subsalicylate may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline
Mannitol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Lomitapide (Compound) and Lomitapide may lead to a major life threatening interaction when taken with Tetracycline