DDInter458 DDInter79
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers . Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure . The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KLHDC2
KLHDC2 {u} (Gene) is upregulated by {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Felodipine
Felodipine {u} (Compound) resembles {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nilvadipine
Nilvadipine {u} (Compound) resembles {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KLHDC2
KLHDC2 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) AARS
AARS {u} (Gene) is regulated by {v} (Gene) NSDHL
NSDHL {u} (Gene) is upregulated by {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Nisoldipine
Nisoldipine {u} (Compound) resembles {v} (Compound) Amlodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) interacts with {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Amlodipine
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Amlodipine (Compound)
Cyclosporine (Compound) upregulates KLHDC2 (Gene) and KLHDC2 (Gene) is upregulated by Amlodipine (Compound)
Cyclosporine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Amlodipine (Compound)
Cyclosporine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Amlodipine (Compound)
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Felodipine (Compound) and Felodipine (Compound) resembles Amlodipine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilvadipine (Compound) and Nilvadipine (Compound) resembles Amlodipine (Compound)
Cyclosporine (Compound) upregulates KLHDC2 (Gene) and KLHDC2 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Amlodipine (Compound)
Cyclosporine (Compound) upregulates AARS (Gene) and AARS (Gene) is regulated by NSDHL (Gene) and NSDHL (Gene) is upregulated by Amlodipine (Compound)
Cyclosporine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Nisoldipine (Compound) and Nisoldipine (Compound) resembles Amlodipine (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) interacts with GRN (Gene) and GRN (Gene) is upregulated by Amlodipine (Compound)