DDInter1887 DDInter255
Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective against Gram-positive bacteria than Gram-negative bacteria when compared to previous fluoroquinolones. Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) causes {v} (Side Effect) Rhinitis
Rhinitis {u} (Side Effect) is caused by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Gemifloxacin {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) regulates {v} (Gene) MAMLD1
MAMLD1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) GPER1
GPER1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Trovafloxacin (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Busulfan (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Trovafloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Busulfan (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Trovafloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) regulates MAMLD1 (Gene) and MAMLD1 (Gene) is upregulated by Busulfan (Compound)
Trovafloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Trovafloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Busulfan (Compound)
Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is regulated by GPER1 (Gene) and GPER1 (Gene) is upregulated by Busulfan (Compound)