DDInter1557 DDInter1376
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Quinine {u} (Compound) resembles {v} (Compound) Quinidine barbiturate
Quinine {u} (Compound) treats {v} (Disease) malaria
Quinine {u} (Compound) binds {v} (Gene) SLC22A4
Quinine {u} (Compound) upregulates {v} (Gene) CPVL
Quinine {u} (Compound) downregulates {v} (Gene) DNAJA3
Quinine {u} (Compound) causes {v} (Side Effect) Optic neuritis
Quinine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Quinine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxycycline
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostemsavir
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aminoglutethimide
Quinine (Compound) resembles Quinidine barbiturate (Compound)
Quinine (Compound) treats malaria (Disease)
Quinine (Compound) binds SLC22A4 (Gene)
Quinine (Compound) upregulates CPVL (Gene)
Quinine (Compound) downregulates DNAJA3 (Gene)
Quinine (Compound) causes Optic neuritis (Side Effect)
Quinine may cause a minor interaction that can limit clinical effects when taken with Modafinil
Quinine may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimide