DDInter1761 DDInter576
Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chemical synthesis of temazepam was established by 1965, mainstream contemporary use of the medication did not occur until it's legitimate use as treatment for insomnia was accepted and approved later on. In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to obtain the necessary rest required for medical recovery or scheduled maneuvers and operations. Regardless, temazepam has become one of the most frequently prescribed medications internationally and sees
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Temazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Temazepam {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Temazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Nitrazepam
Nitrazepam {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Clobazam
Clobazam {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) downregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Chlordiazepoxide
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Temazepam {u} (Compound) resembles {v} (Compound) Flurbiprofen
Flurbiprofen {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Temazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Temazepam (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Disulfiram (Compound)
Temazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Temazepam (Compound) resembles Nitrazepam (Compound) and Nitrazepam (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Disulfiram (Compound)
Temazepam (Compound) resembles Clobazam (Compound) and Clobazam (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Disulfiram (Compound)
Temazepam (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Disulfiram (Compound)
Temazepam (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Disulfiram (Compound)
Temazepam (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Temazepam (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Temazepam (Compound) resembles Flurbiprofen (Compound) and Flurbiprofen (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Disulfiram (Compound)