DDInter458 DDInter696
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) downregulates {v} (Gene) MTERF3
MTERF3 {u} (Gene) is downregulated by {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) downregulates {v} (Gene) MTERF3
MTERF3 {u} (Gene) is downregulated by {v} (Compound) Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is regulated by {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) downregulates {v} (Gene) MBOAT7
MBOAT7 {u} (Gene) is regulated by {v} (Gene) RPP38
RPP38 {u} (Gene) is upregulated by {v} (Compound) Ethotoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ethotoin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Ethotoin
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethotoin (Compound)
Cyclosporine (Compound) downregulates MTERF3 (Gene) and MTERF3 (Gene) is downregulated by Ethotoin (Compound)
Cyclosporine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Ethotoin (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Primidone (Compound) and Primidone (Compound) resembles Ethotoin (Compound)
Cyclosporine (Compound) downregulates MTERF3 (Gene) and MTERF3 (Gene) is downregulated by Phensuximide (Compound) and Phensuximide (Compound) resembles Ethotoin (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ethotoin (Compound)
Cyclosporine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is regulated by CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Ethotoin (Compound)
Cyclosporine (Compound) downregulates MBOAT7 (Gene) and MBOAT7 (Gene) is regulated by RPP38 (Gene) and RPP38 (Gene) is upregulated by Ethotoin (Compound)
Cyclosporine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Ethotoin
Cyclosporine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Primidone (Compound) and Primidone (Compound) resembles Ethotoin (Compound)