DDInter896 DDInter1651
Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553] Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system . Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
Hyoscyamine {u} (Compound) resembles {v} (Compound) Dolasetron
Hyoscyamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Hyoscyamine {u} (Compound) resembles {v} (Compound) Cocaine
Hyoscyamine {u} (Compound) treats {v} (Disease) pancreatitis
Hyoscyamine {u} (Compound) binds {v} (Gene) CHRM4
Hyoscyamine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Hyoscyamine {u} (Compound) downregulates {v} (Gene) DLD
Hyoscyamine {u} (Compound) causes {v} (Side Effect) Angle closure glaucoma
Hyoscyamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Hyoscyamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Hyoscyamine (Compound) resembles Dolasetron (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Hyoscyamine (Compound) resembles Cocaine (Compound)
Hyoscyamine (Compound) treats pancreatitis (Disease)
Hyoscyamine (Compound) binds CHRM4 (Gene)
Hyoscyamine (Compound) palliates Parkinson's disease (Disease)
Hyoscyamine (Compound) downregulates DLD (Gene)
Hyoscyamine (Compound) causes Angle closure glaucoma (Side Effect)
Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Digoxin