DDInter458 DDInter1340
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs . Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is upregulated by {v} (Disease) Barrett's esophagus
Barrett's esophagus {u} (Disease) is treated by {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Optic neuritis
Optic neuritis {u} (Side Effect) is caused by {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is upregulated by {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is palliated by {v} (Compound) Omeprazole
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Omeprazole (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Omeprazole (Compound)
Cyclosporine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Omeprazole (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Omeprazole (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Cyclosporine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is upregulated by Barrett's esophagus (Disease) and Barrett's esophagus (Disease) is treated by Omeprazole (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Esomeprazole (Compound) and Esomeprazole (Compound) resembles Omeprazole (Compound)
Cyclosporine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Cyclosporine (Compound) causes Optic neuritis (Side Effect) and Optic neuritis (Side Effect) is caused by Esomeprazole (Compound) and Esomeprazole (Compound) resembles Omeprazole (Compound)
Cyclosporine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is upregulated by kidney cancer (Disease) and kidney cancer (Disease) is palliated by Omeprazole (Compound)