DDInter458 DDInter790
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Bumetanide
Bumetanide {u} (Compound) resembles {v} (Compound) Furosemide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Cyclosporine {u} (Compound) upregulates {v} (Gene) MAP1LC3B
MAP1LC3B {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) downregulates {v} (Gene) TMPO
TMPO {u} (Gene) regulates {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CANX
CANX {u} (Gene) interacts with {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Furosemide
Cyclosporine {u} (Compound) downregulates {v} (Gene) DNM1L
DNM1L {u} (Gene) is regulated by {v} (Gene) PGD
PGD {u} (Gene) is bound by {v} (Compound) Furosemide
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Furosemide (Compound)
Cyclosporine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Furosemide (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Furosemide (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Bumetanide (Compound) and Bumetanide (Compound) resembles Furosemide (Compound)
Cyclosporine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Furosemide (Compound)
Cyclosporine (Compound) upregulates MAP1LC3B (Gene) and MAP1LC3B (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Furosemide (Compound)
Cyclosporine (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Furosemide (Compound)
Cyclosporine (Compound) downregulates TMPO (Gene) and TMPO (Gene) regulates CA2 (Gene) and CA2 (Gene) is bound by Furosemide (Compound)
Cyclosporine (Compound) upregulates CANX (Gene) and CANX (Gene) interacts with ABCC2 (Gene) and ABCC2 (Gene) is bound by Furosemide (Compound)
Cyclosporine (Compound) downregulates DNM1L (Gene) and DNM1L (Gene) is regulated by PGD (Gene) and PGD (Gene) is bound by Furosemide (Compound)