DDInter1233 DDInter1658
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Mitotane {u} (Compound) binds {v} (Gene) CYP11B1
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
Mitotane {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inducers
Mitotane {u} (Compound) downregulates {v} (Gene) PEG10
Mitotane {u} (Compound) causes {v} (Side Effect) Digestion impaired
Mitotane (Compound) resembles Carbinoxamine (Compound)
Mitotane (Compound) binds CYP11B1 (Gene)
Mitotane (Compound) upregulates ADGRE5 (Gene)
Mitotane (Compound) is included by Cytochrome P450 3A4 Inducers (Pharmacologic Class)
Mitotane (Compound) downregulates PEG10 (Gene)
Mitotane (Compound) causes Digestion impaired (Side Effect)