DDInter1066 DDInter1340
Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures [F4349, L5930, L5948]. It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations [F4349, L5930, L5948]. In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others [F4349, L5930, L5948]. As a result, lidocaine is also considered a class Ib anti-arrhythmic agent [L
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs . Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Lidocaine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Omeprazole
Lidocaine {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Omeprazole
Lidocaine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Omeprazole
Lidocaine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Lidocaine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Lidocaine {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Lidocaine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Lidocaine {u} (Compound) causes {v} (Side Effect) Lightheadedness
Lightheadedness {u} (Side Effect) is caused by {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Lidocaine {u} (Compound) resembles {v} (Compound) Ropivacaine
Ropivacaine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Omeprazole
Lidocaine {u} (Compound) binds {v} (Gene) CYP2C18
CYP2C18 {u} (Gene) is associated with {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Omeprazole
Lidocaine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Omeprazole (Compound)
Lidocaine (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Omeprazole (Compound)
Lidocaine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Omeprazole (Compound)
Lidocaine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Lidocaine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Omeprazole (Compound)
Lidocaine (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Esomeprazole (Compound) and Esomeprazole (Compound) resembles Omeprazole (Compound)
Lidocaine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Omeprazole (Compound)
Lidocaine (Compound) causes Lightheadedness (Side Effect) and Lightheadedness (Side Effect) is caused by Esomeprazole (Compound) and Esomeprazole (Compound) resembles Omeprazole (Compound)
Lidocaine (Compound) resembles Ropivacaine (Compound) and Ropivacaine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Omeprazole (Compound)
Lidocaine (Compound) binds CYP2C18 (Gene) and CYP2C18 (Gene) is associated with prostate cancer (Disease) and prostate cancer (Disease) is palliated by Omeprazole (Compound)