DDInter834 DDInter1651
Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its indication as an adjunct therapy in the treatment of peptic ulcers.[A233570,L33090] Later research, taking advantage of the systemic distribution of muscarinic receptors through the body, found that glycopyrronium could also be used for reducing sweat gland, oral, airway, and gastric secretions; as well as reducing cardiac inhibitory reflexes; and reducing bronchoconstriction in COPD. Glycopyrronium is commonly prescribed as a first line treatment for a wide variety indications and is considered to have a wider therapeutic window than [tiotropium]. Glycopy
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system . Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
Glycopyrronium {u} (Compound) resembles {v} (Compound) Hexylcaine
Glycopyrronium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Glycopyrronium {u} (Compound) resembles {v} (Compound) Oxybutynin
Glycopyrronium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Glycopyrronium {u} (Compound) binds {v} (Gene) CHRM3
Glycopyrronium {u} (Compound) downregulates {v} (Gene) TIMM9
Glycopyrronium {u} (Compound) causes {v} (Side Effect) Abdominal distension
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Benzthiazide
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydrochlorothiazide
Glycopyrronium {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Glycopyrronium (Compound) resembles Hexylcaine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Glycopyrronium (Compound) resembles Oxybutynin (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Glycopyrronium (Compound) binds CHRM3 (Gene)
Glycopyrronium (Compound) downregulates TIMM9 (Gene)
Glycopyrronium (Compound) causes Abdominal distension (Side Effect)
Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Benzthiazide
Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide
Glycopyrronium may lead to a major life threatening interaction when taken with Potassium chloride