DDInter263 DDInter1619
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans. Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection. The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999. According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], . It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome . In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole .
Caffeine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ropinirole
Caffeine {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Ropinirole
Caffeine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is palliated by {v} (Compound) Ropinirole
Caffeine {u} (Compound) resembles {v} (Compound) Oxtriphylline
Oxtriphylline {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ropinirole
Caffeine {u} (Compound) resembles {v} (Compound) Dyphylline
Dyphylline {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Ropinirole
Caffeine {u} (Compound) resembles {v} (Compound) Pentoxifylline
Pentoxifylline {u} (Compound) causes {v} (Side Effect) Scotoma
Scotoma {u} (Side Effect) is caused by {v} (Compound) Ropinirole
Caffeine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Theophylline {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ropinirole
Caffeine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Ropinirole
Caffeine {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Ropinirole
Caffeine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Theophylline
Theophylline {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Ropinirole
Caffeine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ropinirole (Compound)
Caffeine (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Ropinirole (Compound)
Caffeine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is palliated by Ropinirole (Compound)
Caffeine (Compound) resembles Oxtriphylline (Compound) and Oxtriphylline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ropinirole (Compound)
Caffeine (Compound) resembles Dyphylline (Compound) and Dyphylline (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Ropinirole (Compound)
Caffeine (Compound) resembles Pentoxifylline (Compound) and Pentoxifylline (Compound) causes Scotoma (Side Effect) and Scotoma (Side Effect) is caused by Ropinirole (Compound)
Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ropinirole (Compound)
Caffeine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Ropinirole (Compound)
Caffeine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Ropinirole (Compound)
Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Ropinirole (Compound)