DDInter1521 DDInter1676
Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Primidone {u} (Compound) resembles {v} (Compound) Phenytoin
Primidone {u} (Compound) treats {v} (Disease) epilepsy syndrome
Primidone {u} (Compound) binds {v} (Gene) CYP2C9
Primidone {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Central Nervous System Disorganized Electrical Activity
Primidone {u} (Compound) downregulates {v} (Gene) OXA1L
Primidone {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Primidone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcifediol
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Primidone (Compound) resembles Phenobarbital (Compound)
Primidone (Compound) resembles Phenytoin (Compound)
Primidone (Compound) treats epilepsy syndrome (Disease)
Primidone (Compound) binds CYP2C9 (Gene)
Primidone (Compound) is included by Decreased Central Nervous System Disorganized Electrical Activity (Pharmacologic Class)
Primidone (Compound) downregulates OXA1L (Gene)
Primidone (Compound) causes Psychotic disorder (Side Effect)
Primidone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Calcifediol
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine