DDInter458 DDInter1729
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) upregulates {v} (Gene) TP53
TP53 {u} (Gene) interacts with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) downregulates {v} (Gene) NOSIP
NOSIP {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) resembles {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) upregulates {v} (Gene) PDIA5
PDIA5 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is regulated by {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine {u} (Compound) downregulates {v} (Gene) STMN1
STMN1 {u} (Gene) interacts with {v} (Gene) MAPK3
MAPK3 {u} (Gene) is bound by {v} (Compound) Sulindac
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Sulindac (Compound)
Cyclosporine (Compound) upregulates TP53 (Gene) and TP53 (Gene) interacts with PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) downregulates NOSIP (Gene) and NOSIP (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) resembles osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Sulindac (Compound)
Cyclosporine (Compound) upregulates PDIA5 (Gene) and PDIA5 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is regulated by PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Cyclosporine (Compound) downregulates STMN1 (Gene) and STMN1 (Gene) interacts with MAPK3 (Gene) and MAPK3 (Gene) is bound by Sulindac (Compound)