DDInter1791 DDInter1652
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Theophylline {u} (Compound) resembles {v} (Compound) Enprofylline
Theophylline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Caffeine
Theophylline {u} (Compound) treats {v} (Disease) asthma
Theophylline {u} (Compound) binds {v} (Gene) CYP2C9
Theophylline {u} (Compound) upregulates {v} (Gene) UBQLN2
Theophylline {u} (Compound) is included by {v} (Pharmacologic Class) Xanthines
Theophylline {u} (Compound) downregulates {v} (Gene) TES
Theophylline {u} (Compound) causes {v} (Side Effect) Gastric irritation
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Alprazolam
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lorazepam
Theophylline (Compound) resembles Enprofylline (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Caffeine
Theophylline (Compound) treats asthma (Disease)
Theophylline (Compound) binds CYP2C9 (Gene)
Theophylline (Compound) upregulates UBQLN2 (Gene)
Theophylline (Compound) is included by Xanthines (Pharmacologic Class)
Theophylline (Compound) downregulates TES (Gene)
Theophylline (Compound) causes Gastric irritation (Side Effect)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Alprazolam
Theophylline may cause a minor interaction that can limit clinical effects when taken with Lorazepam