DDInter927 DDInter1693
Inotuzumab ozogamicin is an antibody-drug conjugate using linker and cytotoxic drug technology similar to that developed for the ground-breaking treatment Mylotarg (), which was approved by the US FDA in 2000 for the treatment of acute myeloid leukaemia. Inotuzumab ozogamicin consists of a recombinant humanised IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide, which is a potent DNA-binding cytotoxic agent. Developed by Pfizer and UCB, inotuzumab ozogamicin was granted approval by EU in June 2017 followed by FDA on August 17th, 2017 for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). ALL is a rapidly progressing cancer of the bone marrow that is associated with
Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate anhydrous is an electrolyte replenisher and is used in isosmotic solutions so that administration does not disturb normal electrolyte balance and does not lead to absorption or excretion of water and ions.
Sodium sulfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Sodium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxamniquine
Sodium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostemsavir
Sodium sulfate {u} may lead to a major life threatening interaction when taken with {v} Dronedarone
Sodium sulfate may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir
Sodium sulfate may lead to a major life threatening interaction when taken with Dronedarone