DDInter54 DDInter1652
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse effects are generally related to the sedation it can cause. Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. Alprazolam was given FDA approval on October 16, 1981.
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Alprazolam {u} (Compound) resembles {v} (Compound) Brotizolam
Alprazolam {u} (Compound) resembles {v} (Compound) Fludiazepam
Alprazolam {u} (Compound) binds {v} (Gene) CYP3A7
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
Alprazolam {u} (Compound) palliates {v} (Disease) panic disorder
Alprazolam {u} (Compound) is included by {v} (Pharmacologic Class) Benzodiazepines
Alprazolam {u} (Compound) downregulates {v} (Gene) TSPAN4
Alprazolam {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Alprazolam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Alprazolam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prednisolone
Alprazolam (Compound) resembles Brotizolam (Compound)
Alprazolam (Compound) resembles Fludiazepam (Compound)
Alprazolam (Compound) binds CYP3A7 (Gene)
Alprazolam (Compound) upregulates KDM5A (Gene)
Alprazolam (Compound) palliates panic disorder (Disease)
Alprazolam (Compound) is included by Benzodiazepines (Pharmacologic Class)
Alprazolam (Compound) downregulates TSPAN4 (Gene)
Alprazolam (Compound) causes Oedema peripheral (Side Effect)
Alprazolam may cause a minor interaction that can limit clinical effects when taken with Theophylline
Alprazolam may cause a minor interaction that can limit clinical effects when taken with Prednisolone