DDInter336 DDInter480
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor selectivity is clinically advantageous in overactive bladder syndrome treatments.
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Darifenacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Darifenacin
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Darifenacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Darifenacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Alanine aminotransferase increased
Alanine aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Darifenacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Cerebrovascular accident
Cerebrovascular accident {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Darifenacin
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Darifenacin
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Darifenacin
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Darifenacin
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is associated with {v} (Gene) BAD
BAD {u} (Gene) is downregulated by {v} (Compound) Darifenacin
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Darifenacin (Compound)
Celecoxib (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Darifenacin (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Darifenacin (Compound)
Celecoxib (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Darifenacin (Compound)
Celecoxib (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin
Celecoxib (Compound) causes Cerebrovascular accident (Side Effect) and Cerebrovascular accident (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is palliated by Fentanyl (Compound) and Fentanyl (Compound) resembles Darifenacin (Compound)
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Darifenacin (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is associated with BAD (Gene) and BAD (Gene) is downregulated by Darifenacin (Compound)