DDInter1543 DDInter381
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, alpha<sub>1</sub
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Protriptyline {u} (Compound) resembles {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) resembles {v} (Compound) Demexiptiline
Demexiptiline {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Dexfenfluramine {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) resembles {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) resembles {v} (Compound) Demexiptiline
Demexiptiline {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Dexfenfluramine {u} may lead to a major life threatening interaction when taken with {v} Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Protriptyline (Compound) resembles Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Protriptyline (Compound) resembles Demexiptiline (Compound) and Demexiptiline (Compound) resembles Cinacalcet (Compound)
Protriptyline may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine (Compound) resembles Cinacalcet (Compound)
Protriptyline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cinacalcet (Compound)
Protriptyline (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Cinacalcet (Compound)
Protriptyline (Compound) resembles Duloxetine (Compound) and Duloxetine (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Protriptyline (Compound) resembles Demexiptiline (Compound) and Demexiptiline (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Protriptyline may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine (Compound) resembles Cinacalcet (Compound)
Protriptyline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Protriptyline (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)