DDInter1123 DDInter292
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Captopril
Mannitol {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Captopril
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Captopril
Mannitol {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Captopril
Mannitol {u} (Compound) causes {v} (Side Effect) Diabetes mellitus
Diabetes mellitus {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Mannitol {u} (Compound) causes {v} (Side Effect) Acidosis
Acidosis {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Mannitol {u} (Compound) causes {v} (Side Effect) Hypovolaemia
Hypovolaemia {u} (Side Effect) is caused by {v} (Compound) Dapagliflozin
Dapagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Captopril
Mannitol {u} (Compound) resembles {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) causes {v} (Side Effect) Necrosis
Necrosis {u} (Side Effect) is caused by {v} (Compound) Captopril
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is downregulated by {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Captopril
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is associated with {v} (Gene) MMP2
MMP2 {u} (Gene) is bound by {v} (Compound) Captopril
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Captopril (Compound)
Mannitol (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Captopril (Compound)
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Enalapril (Compound) and Enalapril (Compound) resembles Captopril (Compound)
Mannitol (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Captopril (Compound)
Mannitol (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Captopril
Mannitol (Compound) causes Acidosis (Side Effect) and Acidosis (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Captopril
Mannitol (Compound) causes Hypovolaemia (Side Effect) and Hypovolaemia (Side Effect) is caused by Dapagliflozin (Compound) and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Captopril
Mannitol (Compound) resembles Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) causes Necrosis (Side Effect) and Necrosis (Side Effect) is caused by Captopril (Compound)
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is downregulated by systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Captopril (Compound)
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is associated with MMP2 (Gene) and MMP2 (Gene) is bound by Captopril (Compound)