DDInter336 DDInter883
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.
Celecoxib {u} (Compound) binds {v} (Gene) CA5B
CA5B {u} (Gene) is bound by {v} (Compound) Hydrochlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA5B
CA5B {u} (Gene) is bound by {v} (Compound) Diclofenamide
Diclofenamide {u} (Compound) resembles {v} (Compound) Hydrochlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Scopolamine
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydrochlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Diclofenamide
Diclofenamide {u} (Compound) resembles {v} (Compound) Hydrochlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Aplastic anaemia
Aplastic anaemia {u} (Side Effect) is caused by {v} (Compound) Polythiazide
Polythiazide {u} (Compound) resembles {v} (Compound) Hydrochlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Stiffness
Stiffness {u} (Side Effect) is caused by {v} (Compound) Ergocalciferol
Ergocalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrochlorothiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrochlorothiazide
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) upregulates {v} (Gene) WIF1
WIF1 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Celecoxib (Compound) binds CA5B (Gene) and CA5B (Gene) is bound by Hydrochlorothiazide (Compound)
Celecoxib (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Hydrochlorothiazide (Compound)
Celecoxib (Compound) binds CA5B (Gene) and CA5B (Gene) is bound by Diclofenamide (Compound) and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Celecoxib (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Scopolamine (Compound) and Scopolamine may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide
Celecoxib (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Diclofenamide (Compound) and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Celecoxib (Compound) causes Aplastic anaemia (Side Effect) and Aplastic anaemia (Side Effect) is caused by Polythiazide (Compound) and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Celecoxib (Compound) causes Stiffness (Side Effect) and Stiffness (Side Effect) is caused by Ergocalciferol (Compound) and Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide
Celecoxib (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Hydrochlorothiazide (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Hydrochlorothiazide (Compound)