DDInter1729 DDInter657
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Sulindac {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Sulindac {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Dinoprost Tromethamine
Dinoprost Tromethamine {u} (Compound) resembles {v} (Compound) Epoprostenol
Sulindac {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Treprostinil
Treprostinil {u} (Compound) resembles {v} (Compound) Epoprostenol
Sulindac {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Tadalafil
Tadalafil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Epoprostenol
Sulindac {u} (Compound) causes {v} (Side Effect) Pleural effusion
Pleural effusion {u} (Side Effect) is caused by {v} (Compound) Fluoxetine
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epoprostenol
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epoprostenol
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) interacts with {v} (Gene) PTGIS
PTGIS {u} (Gene) is bound by {v} (Compound) Epoprostenol
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Dinoprostone
Dinoprostone {u} (Compound) resembles {v} (Compound) Epoprostenol
Sulindac {u} (Compound) causes {v} (Side Effect) Pleural effusion
Pleural effusion {u} (Side Effect) is caused by {v} (Compound) Rasagiline
Rasagiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epoprostenol
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} (Compound) resembles {v} (Compound) Epoprostenol
Sulindac (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Epoprostenol (Compound)
Sulindac (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Dinoprost Tromethamine (Compound) and Dinoprost Tromethamine (Compound) resembles Epoprostenol (Compound)
Sulindac (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Treprostinil (Compound) and Treprostinil (Compound) resembles Epoprostenol (Compound)
Sulindac (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Tadalafil (Compound) and Tadalafil may cause a minor interaction that can limit clinical effects when taken with Epoprostenol
Sulindac (Compound) causes Pleural effusion (Side Effect) and Pleural effusion (Side Effect) is caused by Fluoxetine (Compound) and Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) interacts with PTGIS (Gene) and PTGIS (Gene) is bound by Epoprostenol (Compound)
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Dinoprostone (Compound) and Dinoprostone (Compound) resembles Epoprostenol (Compound)
Sulindac (Compound) causes Pleural effusion (Side Effect) and Pleural effusion (Side Effect) is caused by Rasagiline (Compound) and Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Treprostinil (Compound) and Treprostinil (Compound) resembles Epoprostenol (Compound)