DDInter1174 DDInter1729
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
Methotrexate {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sulindac
Methotrexate {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Sulindac
Methotrexate {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Sulindac
Methotrexate {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) is bound by {v} (Compound) Sulindac
Methotrexate {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) regulates {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) is bound by {v} (Compound) Sulindac
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Methoxyflurane {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sulindac
Methotrexate {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Sulindac
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Caffeine
Caffeine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sulindac
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Sulindac
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Caffeine
Caffeine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Sulindac
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulindac (Compound)
Methotrexate (Compound) binds ALB (Gene) and ALB (Gene) is bound by Sulindac (Compound)
Methotrexate (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Sulindac (Compound)
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is regulated by AKR1B1 (Gene) and AKR1B1 (Gene) is bound by Sulindac (Compound)
Methotrexate (Compound) binds ALB (Gene) and ALB (Gene) regulates AKR1B1 (Gene) and AKR1B1 (Gene) is bound by Sulindac (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane and Methoxyflurane (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sulindac (Compound)
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is associated with osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Sulindac (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sulindac (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Sulindac (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Sulindac (Compound)