DDInter150 DDInter1819
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Tisagenlecleucel is a CD19-directed genetically modified autologous T cell immunotherapy, or a CAR-T cell therapy for B-cell acute lymphoblastic leukemia. It was granted approval by FDA in August 2017 under the market name Kymriah. Tisagenlecleucel is an immunocellular therapy that involves autologous T cells that are collected from each individual patient and genetically engineered to express a specific protein called a chimeric antigen receptor (CAR) that specifically target CD19 antigens. Modified T cells are infused back into the patient's body. These CD19-directed chimeric antigen receptors (CD19 CAR-T cells) direct the T cells to target and kill leukemia cells that express CD19 on the cell surface. In a multicenter clinical trial involving pediatric and young adult patients with relapsed or refractory B-cell precursor ALL, the overall remission rate within three months of treatment was 83 percent.
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Azathioprine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
Azathioprine {u} (Compound) binds {v} (Gene) GSTA1
Azathioprine {u} (Compound) upregulates {v} (Gene) NUCB2
Azathioprine {u} (Compound) is included by {v} (Pharmacologic Class) Purines
Azathioprine {u} (Compound) downregulates {v} (Gene) STUB1
Azathioprine {u} (Compound) causes {v} (Side Effect) Hodgkin's disease
Azathioprine (Compound) resembles Adenine (Compound)
Azathioprine (Compound) treats systemic lupus erythematosus (Disease)
Azathioprine (Compound) binds GSTA1 (Gene)
Azathioprine (Compound) upregulates NUCB2 (Gene)
Azathioprine (Compound) is included by Purines (Pharmacologic Class)
Azathioprine (Compound) downregulates STUB1 (Gene)
Azathioprine (Compound) causes Hodgkin's disease (Side Effect)