DDInter1042 DDInter1326
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles [clozapine] and only differs by two additional methyl groups and the absence of a chloride moiety. It was discovered by scientists at Eli Lilly and approved to be marketed in the US in 1996.
Olanzapine {u} (Compound) resembles {v} (Compound) Clozapine
Olanzapine {u} (Compound) resembles {v} (Compound) Pirenzepine
Olanzapine {u} (Compound) binds {v} (Gene) HTR7
Olanzapine {u} (Compound) upregulates {v} (Gene) NNT
Olanzapine {u} (Compound) palliates {v} (Disease) Gilles de la Tourette syndrome
Olanzapine {u} (Compound) downregulates {v} (Gene) ITGAE
Olanzapine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Olanzapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Olanzapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acarbose
Olanzapine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Olanzapine (Compound) resembles Clozapine (Compound)
Olanzapine (Compound) resembles Pirenzepine (Compound)
Olanzapine (Compound) binds HTR7 (Gene)
Olanzapine (Compound) upregulates NNT (Gene)
Olanzapine (Compound) palliates Gilles de la Tourette syndrome (Disease)
Olanzapine (Compound) downregulates ITGAE (Gene)
Olanzapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose
Olanzapine may lead to a major life threatening interaction when taken with Potassium chloride