DDInter1521 DDInter899
Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Primidone {u} (Compound) resembles {v} (Compound) Phenytoin
Primidone {u} (Compound) treats {v} (Disease) epilepsy syndrome
Primidone {u} (Compound) binds {v} (Gene) CYP2C9
Primidone {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Central Nervous System Disorganized Electrical Activity
Primidone {u} (Compound) downregulates {v} (Gene) OXA1L
Primidone {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Primidone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcifediol
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Primidone (Compound) resembles Phenobarbital (Compound)
Primidone (Compound) resembles Phenytoin (Compound)
Primidone (Compound) treats epilepsy syndrome (Disease)
Primidone (Compound) binds CYP2C9 (Gene)
Primidone (Compound) is included by Decreased Central Nervous System Disorganized Electrical Activity (Pharmacologic Class)
Primidone (Compound) downregulates OXA1L (Gene)
Primidone (Compound) causes Psychotic disorder (Side Effect)
Primidone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Calcifediol
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine