DDInter676 DDInter1266
Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome. It can also be found in quadruple regimens for the treatment of _H. pylori_ infections along with other antibiotics including,, and, for example.[A177271, F4498] Its efficacy is considered similar to other medications within the PPI class including,,,, and. Esomeprazole is the s-isomer of, which is a racemate of the S- and R-enantiomer. Esomeprazole has been shown to inhibit acid secretion to a similar extent as, without any significant differences between the two compounds _in vitro_. Esome
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Esomeprazole {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Naproxen
Esomeprazole {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Naproxen
Esomeprazole {u} (Compound) resembles {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) resembles {v} (Compound) Omeprazole
Omeprazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Rabeprazole {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) treats {v} (Disease) Barrett's esophagus
Barrett's esophagus {u} (Disease) downregulates {v} (Gene) FAM63A
FAM63A {u} (Gene) is upregulated by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) UGT2B7
UGT2B7 {u} (Gene) is bound by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) treats {v} (Disease) Barrett's esophagus
Barrett's esophagus {u} (Disease) is associated with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Naproxen
Esomeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Naproxen
Esomeprazole (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Naproxen (Compound)
Esomeprazole (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Flurbiprofen (Compound) and Flurbiprofen (Compound) resembles Naproxen (Compound)
Esomeprazole (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Naproxen (Compound)
Esomeprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Naproxen (Compound)
Esomeprazole (Compound) resembles Omeprazole (Compound) and Omeprazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Naproxen (Compound)
Esomeprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Naproxen (Compound)
Esomeprazole (Compound) treats Barrett's esophagus (Disease) and Barrett's esophagus (Disease) downregulates FAM63A (Gene) and FAM63A (Gene) is upregulated by Naproxen (Compound)
Esomeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with UGT2B7 (Gene) and UGT2B7 (Gene) is bound by Naproxen (Compound)
Esomeprazole (Compound) treats Barrett's esophagus (Disease) and Barrett's esophagus (Disease) is associated with PTGS2 (Gene) and PTGS2 (Gene) is bound by Naproxen (Compound) and PTGS2 (Gene) is upregulated by Naproxen (Compound)
Esomeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Naproxen (Compound)