DDInter1340 DDInter1557
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Omeprazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quinine
Omeprazole {u} (Compound) causes {v} (Side Effect) Optic neuritis
Optic neuritis {u} (Side Effect) is caused by {v} (Compound) Quinine
Omeprazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quinidine
Quinidine {u} (Compound) resembles {v} (Compound) Quinine
Omeprazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinine
Omeprazole {u} (Compound) causes {v} (Side Effect) Optic neuritis
Optic neuritis {u} (Side Effect) is caused by {v} (Compound) Quinidine barbiturate
Quinidine barbiturate {u} (Compound) resembles {v} (Compound) Quinine
Omeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quinine
Omeprazole {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) MSRA
MSRA {u} (Gene) is upregulated by {v} (Compound) Quinine
Omeprazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Fluvoxamine
Fluvoxamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinine
Omeprazole {u} (Compound) resembles {v} (Compound) Esomeprazole
Esomeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Quinine
Omeprazole {u} (Compound) causes {v} (Side Effect) Optic neuritis
Optic neuritis {u} (Side Effect) is caused by {v} (Compound) Tizanidine
Tizanidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinine
Omeprazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quinine (Compound)
Omeprazole (Compound) causes Optic neuritis (Side Effect) and Optic neuritis (Side Effect) is caused by Quinine (Compound)
Omeprazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quinidine (Compound) and Quinidine (Compound) resembles Quinine (Compound)
Omeprazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Quinine
Omeprazole (Compound) causes Optic neuritis (Side Effect) and Optic neuritis (Side Effect) is caused by Quinidine barbiturate (Compound) and Quinidine barbiturate (Compound) resembles Quinine (Compound)
Omeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quinine (Compound)
Omeprazole (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates MSRA (Gene) and MSRA (Gene) is upregulated by Quinine (Compound)
Omeprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Fluvoxamine (Compound) and Fluvoxamine may cause a minor interaction that can limit clinical effects when taken with Quinine
Omeprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Quinine (Compound)
Omeprazole (Compound) causes Optic neuritis (Side Effect) and Optic neuritis (Side Effect) is caused by Tizanidine (Compound) and Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Quinine