DDInter410 DDInter1180
Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic ser
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Clomipramine {u} (Compound) resembles {v} (Compound) Adinazolam
Clomipramine {u} (Compound) resembles {v} (Compound) Thioridazine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorpheniramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Clomipramine {u} (Compound) binds {v} (Gene) CYP1A2
Clomipramine {u} (Compound) upregulates {v} (Gene) TGFBR2
Clomipramine {u} (Compound) palliates {v} (Disease) panic disorder
Clomipramine {u} (Compound) causes {v} (Side Effect) Uterine haemorrhage
Clomipramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Clomipramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ammonium chloride
Clomipramine (Compound) resembles Adinazolam (Compound)
Clomipramine (Compound) resembles Thioridazine (Compound)
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clomipramine (Compound) binds CYP1A2 (Gene)
Clomipramine (Compound) upregulates TGFBR2 (Gene)
Clomipramine (Compound) palliates panic disorder (Disease)
Clomipramine (Compound) causes Uterine haemorrhage (Side Effect)
Clomipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Clomipramine may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride