DDInter78 DDInter154
Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Amitriptyline {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Azelastine
Amitriptyline {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Amitriptyline {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Amitriptyline {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Meclizine
Meclizine {u} (Compound) resembles {v} (Compound) Azelastine
Amitriptyline {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) EPCAM
EPCAM {u} (Gene) is upregulated by {v} (Compound) Azelastine
Amitriptyline {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Amitriptyline {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Amitriptyline {u} (Compound) resembles {v} (Compound) Thiothixene
Thiothixene {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Amitriptyline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Azelastine (Compound)
Amitriptyline (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Azelastine (Compound)
Amitriptyline (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Amitriptyline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Meclizine (Compound) and Meclizine (Compound) resembles Azelastine (Compound)
Amitriptyline (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates EPCAM (Gene) and EPCAM (Gene) is upregulated by Azelastine (Compound)
Amitriptyline (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Clemastine (Compound) and Clemastine (Compound) resembles Azelastine (Compound)
Amitriptyline (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Amitriptyline (Compound) resembles Thiothixene (Compound) and Thiothixene (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)