DDInter134 DDInter170
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP synthase responsible for synthesizing ATP. Consequently, bedaquiline can be used to treat mycobacterial infection, particularly tuberculosis (TB). Although the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB) to [isoniazid] and [rifampin] has substantially worsened patients outcome. Bedaquiline was approved by the FDA on December 28, 2012, to treat pulmonary MDR-TB, following favorable results in multiple pre-clinical and clinical studies.[A261856,A261861] It is the first drug that was approved in the last 40 years by the FDA for TB unresponsive to current treatments on the market. Currently, bedaquiline is the last-line anti-TB drug and must only be used in an appropriate combination regimen.[L48506,A261866]
Atovaquone {u} (Compound) resembles {v} (Compound) Anisindione
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acarbose
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Azelastine
Azelastine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Anisindione
Anisindione {u} may lead to a major life threatening interaction when taken with {v} Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Phenindione
Phenindione {u} (Compound) resembles {v} (Compound) Doxepin
Doxepin {u} may lead to a major life threatening interaction when taken with {v} Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Azelastine
Azelastine {u} (Compound) causes {v} (Side Effect) Alanine aminotransferase increased
Alanine aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Anisindione
Anisindione {u} may lead to a major life threatening interaction when taken with {v} Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Anisindione
Anisindione {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxycycline
Doxycycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bedaquiline
Atovaquone {u} (Compound) binds {v} (Gene) DHODH
DHODH {u} (Gene) is bound by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Bedaquiline
Atovaquone {u} (Compound) resembles {v} (Compound) Anisindione
Anisindione {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bupropion
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bedaquiline
Atovaquone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Diphenhydramine {u} (Compound) resembles {v} (Compound) Bedaquiline
Atovaquone (Compound) resembles Anisindione (Compound) and Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline
Atovaquone (Compound) resembles Azelastine (Compound) and Azelastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Atovaquone (Compound) resembles Anisindione (Compound) and Anisindione may lead to a major life threatening interaction when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bedaquiline
Atovaquone (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Doxepin (Compound) and Doxepin may lead to a major life threatening interaction when taken with Bedaquiline
Atovaquone (Compound) resembles Azelastine (Compound) and Azelastine (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Bedaquiline (Compound)
Atovaquone (Compound) resembles Anisindione (Compound) and Anisindione may lead to a major life threatening interaction when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline
Atovaquone (Compound) resembles Anisindione (Compound) and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline
Atovaquone (Compound) binds DHODH (Gene) and DHODH (Gene) is bound by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Bedaquiline
Atovaquone (Compound) resembles Anisindione (Compound) and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline
Atovaquone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diphenhydramine (Compound) and Diphenhydramine (Compound) resembles Bedaquiline (Compound)