DDInter1662 DDInter904
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Sertraline {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Idarubicin
Sertraline {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Sertraline {u} (Compound) binds {v} (Gene) MAOA
MAOA {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Sertraline {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Sertraline {u} (Compound) upregulates {v} (Gene) TMEM97
TMEM97 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Sertraline {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Sertraline {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Idarubicin
Sertraline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Sertraline {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Sertraline (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Sertraline (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Idarubicin (Compound)
Sertraline (Compound) binds MAOA (Gene) and MAOA (Gene) is upregulated by Idarubicin (Compound)
Sertraline (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Idarubicin (Compound)
Sertraline (Compound) upregulates TMEM97 (Gene) and TMEM97 (Gene) is downregulated by Idarubicin (Compound)
Sertraline (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Sertraline (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Idarubicin
Sertraline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Sertraline (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)