DDInter809 DDInter278
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Gatifloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Gatifloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Gatifloxacin {u} (Compound) binds {v} (Gene) ALB
Gatifloxacin {u} (Compound) upregulates {v} (Gene) ABCC5
Gatifloxacin {u} (Compound) downregulates {v} (Gene) RPS4Y1
Gatifloxacin {u} (Compound) causes {v} (Side Effect) Gastritis
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mitomycin
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Procarbazine
Gatifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Gatifloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ferrous fumarate
Gatifloxacin (Compound) resembles Lomefloxacin (Compound)
Gatifloxacin (Compound) resembles Sparfloxacin (Compound)
Gatifloxacin (Compound) binds ALB (Gene)
Gatifloxacin (Compound) upregulates ABCC5 (Gene)
Gatifloxacin (Compound) downregulates RPS4Y1 (Gene)
Gatifloxacin (Compound) causes Gastritis (Side Effect)
Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Mitomycin
Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Procarbazine
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate