DDInter458 DDInter1315
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is downregulated by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Cyclosporine {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Acute coronary syndrome {u} (Side Effect) is caused by {v} (Compound) Pioglitazone
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Cyclosporine {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Acute coronary syndrome {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is upregulated by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is downregulated by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Rosuvastatin (Compound) and Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Cyclosporine (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Pioglitazone (Compound) and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Cyclosporine (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is upregulated by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel