DDInter624 DDInter991
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. The first isotretinoin-containing product was FDA approved on 7 May 1982.
Efavirenz {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) causes {v} (Side Effect) Renal failure acute
Renal failure acute {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) causes {v} (Side Effect) Renal failure acute
Renal failure acute {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) BCL2
BCL2 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Efavirenz {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isotretinoin
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) upregulates {v} (Gene) ELF4
ELF4 {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Efavirenz (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Isotretinoin (Compound)
Efavirenz (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Isotretinoin (Compound)
Efavirenz (Compound) causes Renal failure acute (Side Effect) and Renal failure acute (Side Effect) is caused by Isotretinoin (Compound)
Efavirenz (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Tretinoin (Compound) and Tretinoin (Compound) resembles Isotretinoin (Compound)
Efavirenz (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Tretinoin (Compound) and Tretinoin (Compound) resembles Isotretinoin (Compound)
Efavirenz (Compound) causes Renal failure acute (Side Effect) and Renal failure acute (Side Effect) is caused by Tretinoin (Compound) and Tretinoin (Compound) resembles Isotretinoin (Compound)
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates BCL2 (Gene) and BCL2 (Gene) is downregulated by Isotretinoin (Compound)
Efavirenz (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Efavirenz (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Isotretinoin
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) upregulates ELF4 (Gene) and ELF4 (Gene) is upregulated by Isotretinoin (Compound)