DDInter1662 DDInter1676
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
Sertraline {u} (Compound) upregulates {v} (Gene) CYP51A1
Sertraline {u} (Compound) palliates {v} (Disease) schizophrenia
Sertraline {u} (Compound) downregulates {v} (Gene) MRPL19
Sertraline {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Sertraline (Compound) resembles Maprotiline (Compound)
Sertraline (Compound) binds CYP3A4 (Gene)
Sertraline (Compound) upregulates CYP51A1 (Gene)
Sertraline (Compound) palliates schizophrenia (Disease)
Sertraline (Compound) downregulates MRPL19 (Gene)
Sertraline (Compound) causes Anaphylactic shock (Side Effect)