DDInter1619 DDInter1344
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papaver somniferum_, which is more known as poppies. This plant is an integrant of the Papaveraceae family, and it is characterized by solitary leaves and capsulated fruits. Therefore, opium is a sticky brown resin obtained by collecting and drying the latex that exudes from the poppy pods. Once extracted, opium contains two main groups of alkaloids; the psychoactive constituents which are in the category of phenanthrenes and alkaloids that have no central nervous system effect in the category of isoquinolines. Morphine is the most prevalent and principal alkaloid in opium, and it is responsible for most of the harmful effects of opium. Opium has gradually been superseded by a variety of synthetic opioids and general anesthetics. Some of the isolated derivatives of opium are morphine, noscapine, strychnine, veratrine, colchicine, codeine, and quinine. Opium is a prohibited drug of abuse in most countries, but the illegal production of this drug and its derivatives keeps being registered. There is some legal production of opium in different countries for the obtention of alkaloids by extraction.
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Felodipine
Felodipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Ropinirole {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Felodipine
Felodipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Ropinirole {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Felodipine
Felodipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Ropinirole {u} (Compound) causes {v} (Side Effect) Influenza like illness
Influenza like illness {u} (Side Effect) is caused by {v} (Compound) Tramadol
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Opium
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tramadol
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Opium
Ropinirole {u} (Compound) upregulates {v} (Gene) GHR
GHR {u} (Gene) is upregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Opium
Ropinirole {u} (Compound) upregulates {v} (Gene) GTF2A2
GTF2A2 {u} (Gene) is downregulated by {v} (Compound) Pimozide
Pimozide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Ropinirole {u} (Compound) palliates {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is palliated by {v} (Compound) Selegiline
Selegiline {u} may lead to a major life threatening interaction when taken with {v} Opium
Ropinirole {u} (Compound) palliates {v} (Disease) restless legs syndrome
restless legs syndrome {u} (Disease) is palliated by {v} (Compound) Gabapentin
Gabapentin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Ropinirole {u} (Compound) downregulates {v} (Gene) STXBP2
STXBP2 {u} (Gene) is downregulated by {v} (Compound) Darifenacin
Darifenacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Felodipine (Compound) and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ropinirole (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Felodipine (Compound) and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ropinirole (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Felodipine (Compound) and Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ropinirole (Compound) causes Influenza like illness (Side Effect) and Influenza like illness (Side Effect) is caused by Tramadol (Compound) and Tramadol may lead to a major life threatening interaction when taken with Opium
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tramadol (Compound) and Tramadol may lead to a major life threatening interaction when taken with Opium
Ropinirole (Compound) upregulates GHR (Gene) and GHR (Gene) is upregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Opium
Ropinirole (Compound) upregulates GTF2A2 (Gene) and GTF2A2 (Gene) is downregulated by Pimozide (Compound) and Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ropinirole (Compound) palliates Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is palliated by Selegiline (Compound) and Selegiline may lead to a major life threatening interaction when taken with Opium
Ropinirole (Compound) palliates restless legs syndrome (Disease) and restless legs syndrome (Disease) is palliated by Gabapentin (Compound) and Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Opium
Ropinirole (Compound) downregulates STXBP2 (Gene) and STXBP2 (Gene) is downregulated by Darifenacin (Compound) and Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Opium