DDInter1678 DDInter698
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) upregulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) upregulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) regulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is regulated by {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Sirolimus {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Sirolimus may lead to a major life threatening interaction when taken with Ibandronate and Ibandronate (Compound) resembles Etidronic acid (Compound)
Sirolimus (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Etidronic acid (Compound)
Sirolimus (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Etidronic acid (Compound)
Sirolimus (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Etidronic acid (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Ibandronate and Ibandronate (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Sirolimus (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Etidronic acid (Compound)
Sirolimus (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) regulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Etidronic acid (Compound)
Sirolimus (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is regulated by XBP1 (Gene) and XBP1 (Gene) is upregulated by Etidronic acid (Compound)
Sirolimus (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Sirolimus may lead to a major life threatening interaction when taken with Ibandronate and Ibandronate (Compound) resembles Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)