DDInter1247 DDInter255
Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Moxifloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Moxifloxacin {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Moxifloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Moxifloxacin {u} may lead to a major life threatening interaction when taken with {v} Nilotinib
Nilotinib {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Moxifloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Moxifloxacin {u} may lead to a major life threatening interaction when taken with {v} Nilotinib
Nilotinib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Moxifloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) regulates {v} (Gene) MAMLD1
MAMLD1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Moxifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxyurea
Hydroxyurea {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Moxifloxacin {u} may lead to a major life threatening interaction when taken with {v} Epirubicin
Epirubicin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Moxifloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) GPER1
GPER1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Moxifloxacin (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) regulates MAMLD1 (Gene) and MAMLD1 (Gene) is upregulated by Busulfan (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Hydroxyurea and Hydroxyurea (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Moxifloxacin may lead to a major life threatening interaction when taken with Epirubicin and Epirubicin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is regulated by GPER1 (Gene) and GPER1 (Gene) is upregulated by Busulfan (Compound)