DDInter1729 DDInter1855
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermatoses. Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.[L8246,L8249,L8252,L8255,L8258,L8261,L8264] Triamcinolone was granted FDA approval on 3 December 1957. In October 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection - the first suprachoroidal injection to receive FDA approval - for the treatment of patients with macular edema associated with uveitis.
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Triamcinolone
Sulindac {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Triamcinolone
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Triamcinolone
Sulindac {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} (Compound) resembles {v} (Compound) Triamcinolone
Sulindac {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Budesonide
Budesonide {u} (Compound) resembles {v} (Compound) Triamcinolone
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is downregulated by {v} (Compound) Fluocinonide
Fluocinonide {u} (Compound) resembles {v} (Compound) Triamcinolone
Sulindac {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Fluoxymesterone
Fluoxymesterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Sulindac {u} (Compound) binds {v} (Gene) PTGDR2
PTGDR2 {u} (Gene) is bound by {v} (Compound) Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clobetasol propionate
Clobetasol propionate {u} (Compound) resembles {v} (Compound) Triamcinolone
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Triamcinolone (Compound)
Sulindac (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Triamcinolone (Compound)
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Triamcinolone (Compound)
Sulindac (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Prednisone (Compound) and Prednisone (Compound) resembles Triamcinolone (Compound)
Sulindac (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Budesonide (Compound) and Budesonide (Compound) resembles Triamcinolone (Compound)
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is downregulated by Fluocinonide (Compound) and Fluocinonide (Compound) resembles Triamcinolone (Compound)
Sulindac (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Fluoxymesterone (Compound) and Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone
Sulindac (Compound) binds PTGDR2 (Gene) and PTGDR2 (Gene) is bound by Indomethacin (Compound) and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clobetasol propionate (Compound) and Clobetasol propionate (Compound) resembles Triamcinolone (Compound)