DDInter1956 DDInter666
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of advanced solid tumors .
Zalcitabine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) Eribulin
Zalcitabine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Eribulin
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eribulin
Zalcitabine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is regulated by {v} (Gene) TUBB2A
TUBB2A {u} (Gene) is bound by {v} (Compound) Eribulin
Zalcitabine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idelalisib
Idelalisib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eribulin
Zalcitabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Eribulin
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Fludarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eribulin
Zalcitabine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) regulates {v} (Gene) TUBB3
TUBB3 {u} (Gene) is bound by {v} (Compound) Eribulin
Zalcitabine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eribulin
Zalcitabine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Eribulin
Zalcitabine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Zalcitabine (Compound) resembles Emtricitabine (Compound) and Emtricitabine may cause a minor interaction that can limit clinical effects when taken with Eribulin
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Zalcitabine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is regulated by TUBB2A (Gene) and TUBB2A (Gene) is bound by Eribulin (Compound)
Zalcitabine (Compound) resembles Emtricitabine (Compound) and Emtricitabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Zalcitabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Eribulin (Compound)
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Zalcitabine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) regulates TUBB3 (Gene) and TUBB3 (Gene) is bound by Eribulin (Compound)
Zalcitabine (Compound) resembles Emtricitabine (Compound) and Emtricitabine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Zalcitabine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is treated by Eribulin (Compound)