DDInter1247 DDInter1853
Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Moxifloxacin {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Gatifloxacin {u} (Compound) upregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Gatifloxacin {u} (Compound) downregulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Gatifloxacin {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) BRCA1
BRCA1 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Moxifloxacin {u} (Compound) palliates {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is associated with {v} (Gene) TLR4
TLR4 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Moxifloxacin (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Tretinoin (Compound)
Moxifloxacin (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Moxifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Tretinoin (Compound)
Moxifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin (Compound) upregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Tretinoin (Compound)
Moxifloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Tretinoin (Compound)
Moxifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin (Compound) downregulates CTSL (Gene) and CTSL (Gene) is upregulated by Tretinoin (Compound)
Moxifloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Tretinoin (Compound)
Moxifloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Tretinoin (Compound)
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with BRCA1 (Gene) and BRCA1 (Gene) is upregulated by Tretinoin (Compound)
Moxifloxacin (Compound) palliates chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is associated with TLR4 (Gene) and TLR4 (Gene) is upregulated by Tretinoin (Compound)