DDInter1943 DDInter856
In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are currently being researched for use in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage. Though this research is so far inconclusive, vitamin E remains a popular supplement and is generally considered safe by the FDA[FDA Label].
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Vitamin E {u} (Compound) resembles {v} (Compound) Phylloquinone
Vitamin E {u} (Compound) binds {v} (Gene) NR1I2
Vitamin E {u} (Compound) upregulates {v} (Gene) CDK6
Vitamin E {u} (Compound) downregulates {v} (Gene) PTPRO
Vitamin E {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mogamulizumab
Vitamin E {u} may cause a minor interaction that can limit clinical effects when taken with {v} Infliximab
Vitamin E {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mechlorethamine
Vitamin E {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eptifibatide
Vitamin E (Compound) resembles Phylloquinone (Compound)
Vitamin E (Compound) binds NR1I2 (Gene)
Vitamin E (Compound) upregulates CDK6 (Gene)
Vitamin E (Compound) downregulates PTPRO (Gene)
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Infliximab
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine
Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Eptifibatide