DDInter1042 DDInter758
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.
Fluoxetine {u} (Compound) resembles {v} (Compound) Orphenadrine
Fluoxetine {u} (Compound) resembles {v} (Compound) Duloxetine
Fluoxetine {u} (Compound) binds {v} (Gene) CYP2D6
Fluoxetine {u} (Compound) upregulates {v} (Gene) ALDOC
Fluoxetine {u} (Compound) palliates {v} (Disease) schizophrenia
Fluoxetine {u} (Compound) downregulates {v} (Gene) RPS4Y1
Fluoxetine {u} (Compound) causes {v} (Side Effect) Cystitis
Fluoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Fluoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levothyroxine
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Fluoxetine (Compound) resembles Orphenadrine (Compound)
Fluoxetine (Compound) resembles Duloxetine (Compound)
Fluoxetine (Compound) binds CYP2D6 (Gene)
Fluoxetine (Compound) upregulates ALDOC (Gene)
Fluoxetine (Compound) palliates schizophrenia (Disease)
Fluoxetine (Compound) downregulates RPS4Y1 (Gene)
Fluoxetine (Compound) causes Cystitis (Side Effect)
Fluoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Fluoxetine may cause a minor interaction that can limit clinical effects when taken with Levothyroxine
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine