DDInter571 DDInter1960
A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Diphenoxylate {u} (Compound) resembles {v} (Compound) Methadone
Diphenoxylate {u} (Compound) resembles {v} (Compound) Sulfinpyrazone
Diphenoxylate {u} (Compound) binds {v} (Gene) OPRM1
Diphenoxylate {u} (Compound) downregulates {v} (Gene) HIST1H2BK
Diphenoxylate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketamine
Diphenoxylate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Droperidol
Diphenoxylate {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levacetylmethadol
Diphenoxylate (Compound) resembles Methadone (Compound)
Diphenoxylate (Compound) resembles Sulfinpyrazone (Compound)
Diphenoxylate (Compound) binds OPRM1 (Gene)
Diphenoxylate (Compound) downregulates HIST1H2BK (Gene)
Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Ketamine
Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Droperidol
Diphenoxylate (Compound) resembles Levacetylmethadol (Compound) and Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol