DDInter255 DDInter1623
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotarix is a live attenuated vaccine containing the 89-12 human strain.[Label] Rotavirus vaccines are 90% effective in protecting against severe rotavirus infection.
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Budesonide
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) downregulates {v} (Gene) PRKCD
PRKCD {u} (Gene) is upregulated by {v} (Compound) Budesonide
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Daunorubicin
Daunorubicin {u} may lead to a major life threatening interaction when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) downregulates {v} (Gene) PRKCD
PRKCD {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} may lead to a major life threatening interaction when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) downregulates {v} (Gene) PRKAG2
PRKAG2 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may lead to a major life threatening interaction when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) upregulates {v} (Gene) AURKB
AURKB {u} (Gene) is downregulated by {v} (Compound) Budesonide
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Budesonide
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) upregulates {v} (Gene) AURKB
AURKB {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Budesonide
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rotavirus vaccine
Busulfan {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Carmustine
Carmustine {u} may lead to a major life threatening interaction when taken with {v} Rotavirus vaccine
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Busulfan (Compound) downregulates PRKCD (Gene) and PRKCD (Gene) is upregulated by Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Daunorubicin (Compound) and Daunorubicin may lead to a major life threatening interaction when taken with Rotavirus vaccine
Busulfan (Compound) downregulates PRKCD (Gene) and PRKCD (Gene) is downregulated by Azacitidine (Compound) and Azacitidine may lead to a major life threatening interaction when taken with Rotavirus vaccine
Busulfan (Compound) downregulates PRKAG2 (Gene) and PRKAG2 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may lead to a major life threatening interaction when taken with Rotavirus vaccine
Busulfan (Compound) upregulates AURKB (Gene) and AURKB (Gene) is downregulated by Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Busulfan (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Busulfan (Compound) upregulates AURKB (Gene) and AURKB (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Rotavirus vaccine
Busulfan (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Budesonide (Compound) and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Busulfan (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Carmustine (Compound) and Carmustine may lead to a major life threatening interaction when taken with Rotavirus vaccine