DDInter1397 DDInter1464
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Digitoxin
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) upregulates {v} (Gene) MAP1LC3B
MAP1LC3B {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Trimipramine
Trimipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Lincomycin
Lincomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) upregulates {v} (Gene) MAP1LC3B
MAP1LC3B {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) downregulates {v} (Gene) CDC25A
CDC25A {u} (Gene) is downregulated by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is downregulated by {v} (Compound) Captopril
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Paroxetine {u} (Compound) downregulates {v} (Gene) CDC25A
CDC25A {u} (Gene) is downregulated by {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Picosulfuric acid
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Digitoxin (Compound) and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Paroxetine (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Digitoxin (Compound) and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Paroxetine (Compound) upregulates MAP1LC3B (Gene) and MAP1LC3B (Gene) is upregulated by Digitoxin (Compound) and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Trimipramine (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Paroxetine (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Lincomycin (Compound) and Lincomycin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Paroxetine (Compound) upregulates MAP1LC3B (Gene) and MAP1LC3B (Gene) is upregulated by Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Picosulfuric acid
Paroxetine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Paroxetine (Compound) downregulates CDC25A (Gene) and CDC25A (Gene) is downregulated by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Paroxetine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is downregulated by Captopril (Compound) and Captopril may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Paroxetine (Compound) downregulates CDC25A (Gene) and CDC25A (Gene) is downregulated by Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Picosulfuric acid