DDInter1251 DDInter150
Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants. It is marketed by Roche Pharmaceuticals and was granted FDA approval for the prophylaxis of transplant rejection in 1995. In addition to the above uses, mycophenolate mofetil has also been studied for the treatment of nephritis and other complications of autoimmune diseases. Unlike another immunosuppressant class, the calcineurin inhibitors, MMF generally does not cause nephrotoxicity or fibrosis.[A180799,A180805] Previously, mycophenolic acid
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Mycophenolate mofetil {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) upregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) causes {v} (Side Effect) Liver injury
Liver injury {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) resembles {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) upregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Mycophenolate mofetil {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mycophenolate mofetil (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Mycophenolate mofetil (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Mycophenolate mofetil (Compound) upregulates GTPBP8 (Gene) and GTPBP8 (Gene) is upregulated by Azathioprine (Compound)
Mycophenolate mofetil (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Azathioprine (Compound)
Mycophenolate mofetil (Compound) causes Liver injury (Side Effect) and Liver injury (Side Effect) is caused by Azathioprine (Compound)
Mycophenolate mofetil (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) resembles rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Mycophenolate mofetil (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Mycophenolate mofetil (Compound) upregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Mycophenolate mofetil (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Mycophenolate mofetil (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by RRP1B (Gene) and RRP1B (Gene) is downregulated by Azathioprine (Compound)