DDInter458 DDInter1061
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available. In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLGB1
GOLGB1 {u} (Gene) is upregulated by {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) downregulates {v} (Gene) CSK
CSK {u} (Gene) is upregulated by {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is downregulated by {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Etonogestrel
Etonogestrel {u} (Compound) resembles {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) GOLGB1
GOLGB1 {u} (Gene) is upregulated by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) downregulates {v} (Gene) CSK
CSK {u} (Gene) is upregulated by {v} (Compound) Danazol
Danazol {u} (Compound) resembles {v} (Compound) Levonorgestrel
Cyclosporine {u} (Compound) upregulates {v} (Gene) COPB2
COPB2 {u} (Gene) is upregulated by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Levonorgestrel
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levonorgestrel (Compound)
Cyclosporine (Compound) upregulates GOLGB1 (Gene) and GOLGB1 (Gene) is upregulated by Levonorgestrel (Compound)
Cyclosporine (Compound) downregulates CSK (Gene) and CSK (Gene) is upregulated by Levonorgestrel (Compound)
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Levonorgestrel (Compound)
Cyclosporine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregulated by Levonorgestrel (Compound)
Cyclosporine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Levonorgestrel (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etonogestrel (Compound) and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Cyclosporine (Compound) upregulates GOLGB1 (Gene) and GOLGB1 (Gene) is upregulated by Norethisterone (Compound) and Norethisterone (Compound) resembles Levonorgestrel (Compound)
Cyclosporine (Compound) downregulates CSK (Gene) and CSK (Gene) is upregulated by Danazol (Compound) and Danazol (Compound) resembles Levonorgestrel (Compound)
Cyclosporine (Compound) upregulates COPB2 (Gene) and COPB2 (Gene) is upregulated by Testosterone (Compound) and Testosterone (Compound) resembles Levonorgestrel (Compound)