DDInter569 DDInter1960
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Diphenhydramine {u} (Compound) resembles {v} (Compound) Toremifene
Diphenhydramine {u} (Compound) resembles {v} (Compound) Tropicamide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Diphenhydramine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Diphenhydramine {u} (Compound) treats {v} (Disease) atopic dermatitis
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
Diphenhydramine {u} (Compound) palliates {v} (Disease) schizophrenia
Diphenhydramine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Dizziness
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Diphenhydramine (Compound) resembles Toremifene (Compound)
Diphenhydramine (Compound) resembles Tropicamide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Diphenhydramine may lead to a major life threatening interaction when taken with Tamoxifen
Diphenhydramine (Compound) treats atopic dermatitis (Disease)
Diphenhydramine (Compound) binds CYP2B6 (Gene)
Diphenhydramine (Compound) palliates schizophrenia (Disease)
Diphenhydramine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Diphenhydramine (Compound) causes Dizziness (Side Effect)