DDInter672 DDInter832
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class. Escitalopram also differentiates itself from
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Escitalopram {u} (Compound) resembles {v} (Compound) Citalopram
Escitalopram {u} (Compound) binds {v} (Gene) CYP3A4
Escitalopram {u} (Compound) upregulates {v} (Gene) RRS1
Escitalopram {u} (Compound) palliates {v} (Disease) bipolar disorder
Escitalopram {u} (Compound) is included by {v} (Pharmacologic Class) Serotonin Uptake Inhibitors
Escitalopram {u} (Compound) downregulates {v} (Gene) VAT1
Escitalopram {u} (Compound) causes {v} (Side Effect) Dysmenorrhoea
Escitalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Miconazole
Escitalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ivacaftor
Escitalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Escitalopram (Compound) resembles Citalopram (Compound)
Escitalopram (Compound) binds CYP3A4 (Gene)
Escitalopram (Compound) upregulates RRS1 (Gene)
Escitalopram (Compound) palliates bipolar disorder (Disease)
Escitalopram (Compound) is included by Serotonin Uptake Inhibitors (Pharmacologic Class)
Escitalopram (Compound) downregulates VAT1 (Gene)
Escitalopram (Compound) causes Dysmenorrhoea (Side Effect)
Escitalopram may cause a minor interaction that can limit clinical effects when taken with Miconazole
Escitalopram may cause a minor interaction that can limit clinical effects when taken with Ivacaftor
Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine