DDInter600 DDInter1397
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Doxylamine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) regulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) resembles {v} (Compound) Toremifene
Toremifene {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) regulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Doxylamine {u} (Compound) resembles {v} (Compound) Toremifene
Toremifene {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Paroxetine (Compound)
Doxylamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Paroxetine (Compound)
Doxylamine (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) regulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Doxylamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Doxylamine (Compound) resembles Toremifene (Compound) and Toremifene (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) regulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Paroxetine (Compound)
Doxylamine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Doxylamine (Compound) resembles Toremifene (Compound) and Toremifene (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)