DDInter154 DDInter1960
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Azelastine {u} (Compound) resembles {v} (Compound) Mazindol
Azelastine {u} (Compound) binds {v} (Gene) CYP1A2
Azelastine {u} (Compound) upregulates {v} (Gene) MAL
Azelastine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Azelastine {u} (Compound) downregulates {v} (Gene) CANT1
Azelastine {u} (Compound) causes {v} (Side Effect) Dermatitis contact
Azelastine (Compound) resembles Loxapine (Compound)
Azelastine (Compound) resembles Mazindol (Compound)
Azelastine (Compound) binds CYP1A2 (Gene)
Azelastine (Compound) upregulates MAL (Gene)
Azelastine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Azelastine (Compound) downregulates CANT1 (Gene)
Azelastine (Compound) causes Dermatitis contact (Side Effect)