DDInter535 DDInter1553
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].
Diazoxide {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Diazoxide {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Diazoxide {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Nefazodone {u} (Compound) resembles {v} (Compound) Quetiapine
Diazoxide {u} (Compound) downregulates {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) regulates {v} (Gene) AMDHD2
AMDHD2 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Diazoxide {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Trazodone
Trazodone {u} (Compound) resembles {v} (Compound) Quetiapine
Diazoxide {u} (Compound) causes {v} (Side Effect) Cerebral ischaemia
Cerebral ischaemia {u} (Side Effect) is caused by {v} (Compound) Cilostazol
Cilostazol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quetiapine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Diazoxide {u} (Compound) downregulates {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) is regulated by {v} (Gene) DNM1
DNM1 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Diazoxide {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Quetiapine
Diazoxide {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quetiapine
Diazoxide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Quetiapine (Compound)
Diazoxide (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Quetiapine (Compound)
Diazoxide (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Nefazodone (Compound) and Nefazodone (Compound) resembles Quetiapine (Compound)
Diazoxide (Compound) downregulates ITGB1BP1 (Gene) and ITGB1BP1 (Gene) regulates AMDHD2 (Gene) and AMDHD2 (Gene) is upregulated by Quetiapine (Compound)
Diazoxide (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Trazodone (Compound) and Trazodone (Compound) resembles Quetiapine (Compound)
Diazoxide (Compound) causes Cerebral ischaemia (Side Effect) and Cerebral ischaemia (Side Effect) is caused by Cilostazol (Compound) and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Quetiapine (Compound)
Diazoxide (Compound) downregulates ITGB1BP1 (Gene) and ITGB1BP1 (Gene) is regulated by DNM1 (Gene) and DNM1 (Gene) is upregulated by Quetiapine (Compound)
Diazoxide (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Quetiapine (Compound)
Diazoxide (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Quetiapine