DDInter1821 DDInter1055
Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm [FDA label].
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Tizanidine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) causes {v} (Side Effect) Euphoric mood
Euphoric mood {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) resembles {v} (Compound) Brimonidine
Brimonidine {u} (Compound) causes {v} (Side Effect) Diabetes mellitus
Diabetes mellitus {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) resembles {v} (Compound) Clonidine
Clonidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) binds {v} (Gene) NISCH
NISCH {u} (Gene) covaries with {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) binds {v} (Gene) ADRA2C
ADRA2C {u} (Gene) regulates {v} (Gene) SDC1
SDC1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Tizanidine {u} (Compound) binds {v} (Gene) NISCH
NISCH {u} (Gene) regulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Tizanidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Tizanidine (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Tizanidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Levofloxacin (Compound)
Tizanidine (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Tizanidine (Compound) causes Euphoric mood (Side Effect) and Euphoric mood (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Tizanidine (Compound) resembles Brimonidine (Compound) and Brimonidine (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Levofloxacin (Compound)
Tizanidine (Compound) resembles Clonidine (Compound) and Clonidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Tizanidine (Compound) binds NISCH (Gene) and NISCH (Gene) covaries with ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Levofloxacin (Compound)
Tizanidine (Compound) binds ADRA2C (Gene) and ADRA2C (Gene) regulates SDC1 (Gene) and SDC1 (Gene) is downregulated by Levofloxacin (Compound)
Tizanidine (Compound) binds NISCH (Gene) and NISCH (Gene) regulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Levofloxacin (Compound)