DDInter1607 DDInter1168
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Ritonavir {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Ritonavir {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) resembles {v} (Compound) Methdilazine
Ritonavir {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ritonavir {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Ritonavir {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ritonavir {u} (Compound) causes {v} (Side Effect) Cough increased
Cough increased {u} (Side Effect) is caused by {v} (Compound) Mirtazapine
Mirtazapine {u} (Compound) resembles {v} (Compound) Methdilazine
Ritonavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Promethazine
Promethazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ritonavir {u} (Compound) causes {v} (Side Effect) Cough increased
Cough increased {u} (Side Effect) is caused by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ritonavir {u} (Compound) downregulates {v} (Gene) NT5DC2
NT5DC2 {u} (Gene) is downregulated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ritonavir {u} (Compound) downregulates {v} (Gene) NT5DC2
NT5DC2 {u} (Gene) is downregulated by {v} (Compound) Methyldopa
Methyldopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Ritonavir (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Ritonavir (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pipotiazine (Compound) and Pipotiazine (Compound) resembles Methdilazine (Compound)
Ritonavir (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ritonavir (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Ritonavir (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ritonavir (Compound) causes Cough increased (Side Effect) and Cough increased (Side Effect) is caused by Mirtazapine (Compound) and Mirtazapine (Compound) resembles Methdilazine (Compound)
Ritonavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Promethazine (Compound) and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ritonavir (Compound) causes Cough increased (Side Effect) and Cough increased (Side Effect) is caused by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ritonavir (Compound) downregulates NT5DC2 (Gene) and NT5DC2 (Gene) is downregulated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Ritonavir (Compound) downregulates NT5DC2 (Gene) and NT5DC2 (Gene) is downregulated by Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine