DDInter747 DDInter119
Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position of the steroid structure - this fluorination is thought to be crucial to fludrocortisone's significant mineralocorticoid potency.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Fludrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Testosterone
Fludrocortisone {u} (Compound) binds {v} (Gene) NR3C1
Fludrocortisone {u} (Compound) palliates {v} (Disease) Parkinson's disease
Fludrocortisone {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticlopidine
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisacodyl
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Certolizumab pegol
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Moxifloxacin
Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Testosterone
Fludrocortisone (Compound) binds NR3C1 (Gene)
Fludrocortisone (Compound) palliates Parkinson's disease (Disease)
Fludrocortisone (Compound) causes Hyperglycaemia (Side Effect)
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Ticlopidine
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Fludrocortisone may lead to a major life threatening interaction when taken with Certolizumab pegol
Fludrocortisone may lead to a major life threatening interaction when taken with Moxifloxacin