DDInter458 DDInter1139
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is upregulated by {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is regulated by {v} (Gene) ZNF586
ZNF586 {u} (Gene) is downregulated by {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) resembles {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Mefenamic acid (Compound)
Cyclosporine (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is upregulated by Mefenamic acid (Compound)
Cyclosporine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Mefenamic acid (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Cyclosporine (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is regulated by ZNF586 (Gene) and ZNF586 (Gene) is downregulated by Mefenamic acid (Compound)
Cyclosporine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Cyclosporine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Mefenamic acid (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Acetylsalicylic acid (Compound) and Acetylsalicylic acid (Compound) resembles Mefenamic acid (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)