DDInter1902 DDInter150
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Uracil mustard {u} (Compound) resembles {v} (Compound) Fluorouracil
Fluorouracil {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Uracil mustard {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Gemifloxacin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Uracil mustard {u} (Compound) resembles {v} (Compound) Fluorouracil
Fluorouracil {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Uracil mustard {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Moxifloxacin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Uracil mustard {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Gatifloxacin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ceftazidime
Ceftazidime {u} (Compound) causes {v} (Side Effect) Hepatobiliary disease
Hepatobiliary disease {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Ganciclovir {u} (Compound) is included by {v} (Pharmacologic Class) Nucleoside Analog
Nucleoside Analog {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vitamin E
Vitamin E {u} (Compound) binds {v} (Gene) GSTA2
GSTA2 {u} (Gene) is bound by {v} (Compound) Azathioprine
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Ganciclovir {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Uracil mustard {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Topotecan {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Uracil mustard (Compound) resembles Fluorouracil (Compound) and Fluorouracil (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) and Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) includes Azathioprine (Compound)
Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Azathioprine (Compound)
Uracil mustard (Compound) resembles Fluorouracil (Compound) and Fluorouracil (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Azathioprine (Compound)
Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Azathioprine (Compound)
Uracil mustard may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin and Gatifloxacin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Azathioprine (Compound)
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Azathioprine (Compound)
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E (Compound) binds GSTA2 (Gene) and GSTA2 (Gene) is bound by Azathioprine (Compound)
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)