DDInter5 DDInter1625
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. It is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. Although approved for the treatment of rheumatoid arthritis, Repligen has entered a slightly different formulation of CTLA4-Ig into clinical trials (RG2077).
Rubella virus vaccine is a live attenuated virus vaccine for active immunization against rubella (German measles) that is subcutaneously administered. It is prepared from RA 27/3 strain of live attenuated rubella virus. Rubella is a common childhood disease, caused by rubella virus (togavirus).
Abatacept {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zinc gluconate
Abatacept {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Abatacept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Abatacept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alemtuzumab
Abatacept {u} may lead to a major life threatening interaction when taken with {v} Certolizumab pegol
Abatacept {u} may lead to a major life threatening interaction when taken with {v} Natalizumab
Abatacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Abatacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Abatacept may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Abatacept may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab
Abatacept may lead to a major life threatening interaction when taken with Certolizumab pegol
Abatacept may lead to a major life threatening interaction when taken with Natalizumab