DDInter542 DDInter1947
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase inhibitors. A recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier studies). Further brain tumor trials are planned using combinations of vorinostat with other drugs.
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) is downregulated by {v} (Compound) Vorinostat
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) is regulated by {v} (Gene) HDAC6
HDAC6 {u} (Gene) is bound by {v} (Compound) Vorinostat
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) regulates {v} (Gene) TIMP2
TIMP2 {u} (Gene) is upregulated by {v} (Compound) Vorinostat
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Albiglutide
Albiglutide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorinostat
Dicoumarol {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is regulated by {v} (Gene) NFIL3
NFIL3 {u} (Gene) is upregulated by {v} (Compound) Vorinostat
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may lead to a major life threatening interaction when taken with {v} Vorinostat
Dicoumarol {u} (Compound) resembles {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is upregulated by {v} (Compound) Vorinostat
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) is downregulated by Vorinostat (Compound)
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) is regulated by HDAC6 (Gene) and HDAC6 (Gene) is bound by Vorinostat (Compound)
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) regulates TIMP2 (Gene) and TIMP2 (Gene) is upregulated by Vorinostat (Compound)
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide and Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Vorinostat
Dicoumarol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is regulated by NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Vorinostat (Compound)
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Valproic acid (Compound) and Valproic acid may lead to a major life threatening interaction when taken with Vorinostat
Dicoumarol (Compound) resembles Acenocoumarol (Compound) and Acenocoumarol (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is upregulated by Vorinostat (Compound)