DDInter1938 DDInter809
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Vincristine {u} (Compound) upregulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) upregulates {v} (Gene) ILK
ILK {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Vincristine {u} (Compound) upregulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) regulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) upregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) BID
BID {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is regulated by {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Vincristine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Vincristine (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Gatifloxacin (Compound)
Vincristine (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Gatifloxacin (Compound)
Vincristine (Compound) upregulates ILK (Gene) and ILK (Gene) is downregulated by Gatifloxacin (Compound)
Vincristine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Gatifloxacin (Compound)
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Vincristine (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) regulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Gatifloxacin (Compound)
Vincristine (Compound) upregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by BID (Gene) and BID (Gene) is upregulated by Gatifloxacin (Compound)
Vincristine (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is regulated by SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Gatifloxacin (Compound)
Vincristine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Enoxacin (Compound) and Enoxacin (Compound) resembles Gatifloxacin (Compound)