DDInter336 DDInter1199
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Metolazone
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypophosphataemia
Hypophosphataemia {u} (Side Effect) is caused by {v} (Compound) Amphotericin B
Amphotericin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metolazone
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Benzthiazide
Benzthiazide {u} (Compound) resembles {v} (Compound) Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Trospium
Trospium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Stevens-Johnson syndrome {u} (Side Effect) is caused by {v} (Compound) Methyclothiazide
Methyclothiazide {u} (Compound) resembles {v} (Compound) Metolazone
Celecoxib {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Acarbose
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metolazone
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Metolazone (Compound)
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Metolazone (Compound)
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Indapamide (Compound) and Indapamide (Compound) resembles Metolazone (Compound)
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Metolazone (Compound)
Celecoxib (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Atropine (Compound) and Atropine may cause a minor interaction that can limit clinical effects when taken with Metolazone
Celecoxib (Compound) causes Hypophosphataemia (Side Effect) and Hypophosphataemia (Side Effect) is caused by Amphotericin B (Compound) and Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Metolazone
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Benzthiazide (Compound) and Benzthiazide (Compound) resembles Metolazone (Compound)
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Trospium (Compound) and Trospium may cause a minor interaction that can limit clinical effects when taken with Metolazone
Celecoxib (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Methyclothiazide (Compound) and Methyclothiazide (Compound) resembles Metolazone (Compound)
Celecoxib (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Acarbose (Compound) and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Metolazone