DDInter458 DDInter1254
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) downregulates {v} (Gene) GMNN
GMNN {u} (Gene) is downregulated by {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) downregulates {v} (Gene) GMNN
GMNN {u} (Gene) is regulated by {v} (Gene) PIK3CA
PIK3CA {u} (Gene) is downregulated by {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Melatonin
Melatonin {u} (Compound) resembles {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Nabumetone
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Nabumetone (Compound)
Cyclosporine (Compound) downregulates GMNN (Gene) and GMNN (Gene) is downregulated by Nabumetone (Compound)
Cyclosporine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Nabumetone (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Naproxen (Compound) and Naproxen (Compound) resembles Nabumetone (Compound)
Cyclosporine (Compound) downregulates GMNN (Gene) and GMNN (Gene) is regulated by PIK3CA (Gene) and PIK3CA (Gene) is downregulated by Nabumetone (Compound)
Cyclosporine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Naproxen (Compound) and Naproxen (Compound) resembles Nabumetone (Compound)
Cyclosporine (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone
Cyclosporine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Melatonin (Compound) and Melatonin (Compound) resembles Nabumetone (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Naproxen (Compound) and Naproxen (Compound) resembles Nabumetone (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with MPO (Gene) and MPO (Gene) is bound by Nabumetone (Compound)