DDInter776 DDInter125
Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major clinical advantage of formoterol over other inhaled beta-agonists is its rapid onset of action (2-3 minutes), which is at least as fast as [salbutamol], combined with a long duration of action (12 hours) - for this reason, treatment guidelines for asthma recommend its use as both a reliever and maintenance medication. It is available as a single-entity product [L10986,L11223] and in several formulations in combination with both inhaled corticosteroids [L10995,L10619] and long-acting
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Formoterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Formoterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Asenapine
Formoterol {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Formoterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Formoterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Formoterol {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Formoterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Formoterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) interacts with {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Asenapine
Formoterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Formoterol {u} (Compound) binds {v} (Gene) ADRB1
ADRB1 {u} (Gene) interacts with {v} (Gene) DRD4
DRD4 {u} (Gene) is bound by {v} (Compound) Asenapine
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Asenapine (Compound)
Formoterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Asenapine (Compound)
Formoterol (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Formoterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Formoterol (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)
Formoterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) interacts with ADRA2A (Gene) and ADRA2A (Gene) is bound by Asenapine (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Formoterol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) interacts with DRD4 (Gene) and DRD4 (Gene) is bound by Asenapine (Compound)