DDInter1102 DDInter1180
Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the treatment of schizophrenia. It has a unique receptor binding profile and differs from other antipsychotics in that it modulates glutamate, serotonin and dopamine, which are all neurotransmitters that contribute to the pathophysiology of schizophrenia.[A189093,A189174] The data so far indicates that lumateperone can alleviate both positive and negative symptoms of schizophrenia. Further, not only is the new antipsychotic selective for dopamine (D2) receptors in the mesolimbic and mesocortical brain regions, but it also has minimal off-target activity.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Lumateperone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostamatinib
Lumateperone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Lumateperone {u} may lead to a major life threatening interaction when taken with {v} Apalutamide
Lumateperone {u} may lead to a major life threatening interaction when taken with {v} Prednisone
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Metformin
Lumateperone may lead to a major life threatening interaction when taken with Apalutamide
Lumateperone may lead to a major life threatening interaction when taken with Prednisone