DDInter112 DDInter1139
Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Aprepitant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Diclofenac {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Mefenamic acid
Aprepitant {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Mefenamic acid
Aprepitant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} (Compound) causes {v} (Side Effect) Tremor
Tremor {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Mefenamic acid (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac (Compound) resembles Mefenamic acid (Compound)
Aprepitant (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Mefenamic acid (Compound)
Aprepitant (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Mefenamic acid (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Aprepitant (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Aprepitant (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)
Aprepitant (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Mefenamic acid (Compound)
Aprepitant may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil (Compound) resembles Ketoprofen (Compound) and Ketoprofen (Compound) resembles Mefenamic acid (Compound)