DDInter1257 DDInter535
A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Nalbuphine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Nalbuphine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Nalbuphine {u} (Compound) resembles {v} (Compound) Oxycodone
Oxycodone {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Nalbuphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxone
Naloxone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Nalbuphine {u} (Compound) resembles {v} (Compound) Hydromorphone
Hydromorphone {u} (Compound) causes {v} (Side Effect) Lightheadedness
Lightheadedness {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Nalbuphine {u} may lead to a major life threatening interaction when taken with {v} Morphine
Morphine {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Nalbuphine {u} may lead to a major life threatening interaction when taken with {v} Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Nalbuphine {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Nalbuphine {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is regulated by {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Nalbuphine {u} (Compound) upregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is regulated by {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Nalbuphine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Nalbuphine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Nalbuphine (Compound) resembles Oxycodone (Compound) and Oxycodone (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Diazoxide (Compound)
Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone and Naloxone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Diazoxide (Compound)
Nalbuphine (Compound) resembles Hydromorphone (Compound) and Hydromorphone (Compound) causes Lightheadedness (Side Effect) and Lightheadedness (Side Effect) is caused by Diazoxide (Compound)
Nalbuphine may lead to a major life threatening interaction when taken with Morphine and Morphine (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Diazoxide (Compound)
Nalbuphine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Nalbuphine (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diazoxide (Compound)
Nalbuphine (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is regulated by PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Nalbuphine (Compound) upregulates JADE2 (Gene) and JADE2 (Gene) is regulated by EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Diazoxide (Compound)