DDInter1251 DDInter1055
Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants. It is marketed by Roche Pharmaceuticals and was granted FDA approval for the prophylaxis of transplant rejection in 1995. In addition to the above uses, mycophenolate mofetil has also been studied for the treatment of nephritis and other complications of autoimmune diseases. Unlike another immunosuppressant class, the calcineurin inhibitors, MMF generally does not cause nephrotoxicity or fibrosis.[A180799,A180805] Previously, mycophenolic acid
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Mycophenolate mofetil {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) causes {v} (Side Effect) Hyperkinesia
Hyperkinesia {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) resembles {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} (Compound) upregulates {v} (Gene) PTPN1
PTPN1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) downregulates {v} (Gene) ZNF395
ZNF395 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) resembles {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mycophenolate mofetil {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Mycophenolate mofetil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Mycophenolate mofetil (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Mycophenolate mofetil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Mycophenolate mofetil (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Mycophenolate mofetil (Compound) causes Hyperkinesia (Side Effect) and Hyperkinesia (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound) and Mycophenolic acid (Compound) upregulates PTPN1 (Gene) and PTPN1 (Gene) is downregulated by Levofloxacin (Compound)
Mycophenolate mofetil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Mycophenolate mofetil (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) downregulates ZNF395 (Gene) and ZNF395 (Gene) is downregulated by Levofloxacin (Compound)
Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound) and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Levofloxacin (Compound)
Mycophenolate mofetil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)