DDInter815 DDInter1763
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by _Pseudomonas aeruginosa_.[A233325,A234359,A234364] There is the added benefit of synergy when gentamicin is co-administered with other antibacterials such as beta-lactams. This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects.[A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications,
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) resembles {v} (Compound) Tobramycin
Tobramycin {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) MTOR
MTOR {u} (Gene) is bound by {v} (Compound) Temsirolimus
Gentamicin {u} (Compound) downregulates {v} (Gene) PRPF4
PRPF4 {u} (Gene) is regulated by {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Gentamicin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Gentamicin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Temsirolimus (Compound)
Gentamicin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Temsirolimus (Compound)
Gentamicin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Gentamicin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Gentamicin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Gentamicin (Compound) resembles Tobramycin (Compound) and Tobramycin (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Temsirolimus (Compound)
Gentamicin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Gentamicin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by MTOR (Gene) and MTOR (Gene) is bound by Temsirolimus (Compound)
Gentamicin (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is regulated by MYC (Gene) and MYC (Gene) is upregulated by Temsirolimus (Compound)