DDInter1233 DDInter1353
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
Mitotane {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Ospemifene
Mitotane {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Dapagliflozin
Dapagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ospemifene
Mitotane {u} (Compound) causes {v} (Side Effect) Breast disorder
Breast disorder {u} (Side Effect) is caused by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ospemifene
Mitotane {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Pentamidine
Pentamidine {u} (Compound) resembles {v} (Compound) Ospemifene
Mitotane {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ospemifene
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is downregulated by {v} (Compound) Pentamidine
Pentamidine {u} (Compound) resembles {v} (Compound) Ospemifene
Mitotane {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Pentamidine
Pentamidine {u} (Compound) resembles {v} (Compound) Ospemifene
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Ospemifene
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is downregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ospemifene
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Orlistat
Orlistat {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ospemifene
Mitotane (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Ospemifene (Compound)
Mitotane (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Dapagliflozin (Compound) and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene
Mitotane (Compound) causes Breast disorder (Side Effect) and Breast disorder (Side Effect) is caused by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene
Mitotane (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Pentamidine (Compound) and Pentamidine (Compound) resembles Ospemifene (Compound)
Mitotane (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is downregulated by Pentamidine (Compound) and Pentamidine (Compound) resembles Ospemifene (Compound)
Mitotane (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Pentamidine (Compound) and Pentamidine (Compound) resembles Ospemifene (Compound)
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Clomifene (Compound) and Clomifene (Compound) resembles Ospemifene (Compound)
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is downregulated by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Orlistat (Compound) and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene