DDInter1420 DDInter1658
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Pentamidine {u} (Compound) resembles {v} (Compound) Ospemifene
Pentamidine {u} (Compound) binds {v} (Gene) S100B
Pentamidine {u} (Compound) upregulates {v} (Gene) CDK7
Pentamidine {u} (Compound) downregulates {v} (Gene) TYMS
Pentamidine {u} (Compound) causes {v} (Side Effect) Azotaemia
Pentamidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gilteritinib
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Macimorelin
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Pentamidine (Compound) resembles Ospemifene (Compound)
Pentamidine (Compound) binds S100B (Gene)
Pentamidine (Compound) upregulates CDK7 (Gene)
Pentamidine (Compound) downregulates TYMS (Gene)
Pentamidine (Compound) causes Azotaemia (Side Effect)
Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Galantamine
Pentamidine may lead to a major life threatening interaction when taken with Macimorelin
Pentamidine may lead to a major life threatening interaction when taken with Bexarotene