DDInter1355 DDInter1763
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) ATP7B
ATP7B {u} (Gene) is associated with {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Temsirolimus
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) CA4
CA4 {u} (Gene) is downregulated by {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) regulates {v} (Gene) TCTN1
TCTN1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) regulates {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is regulated by {v} (Gene) NUP88
NUP88 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) SLC31A1
SLC31A1 {u} (Gene) is regulated by {v} (Gene) MTOR
MTOR {u} (Gene) is bound by {v} (Compound) Temsirolimus
Oxaliplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Oxaliplatin (Compound) binds ATP7B (Gene) and ATP7B (Gene) is associated with kidney cancer (Disease) and kidney cancer (Disease) is treated by Temsirolimus (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Oxaliplatin (Compound) binds CA4 (Gene) and CA4 (Gene) is downregulated by kidney cancer (Disease) and kidney cancer (Disease) is treated by Temsirolimus (Compound)
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) regulates TCTN1 (Gene) and TCTN1 (Gene) is upregulated by Temsirolimus (Compound)
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) regulates HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Temsirolimus (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is regulated by NUP88 (Gene) and NUP88 (Gene) is downregulated by Temsirolimus (Compound)
Oxaliplatin (Compound) binds SLC31A1 (Gene) and SLC31A1 (Gene) is regulated by MTOR (Gene) and MTOR (Gene) is bound by Temsirolimus (Compound)
Oxaliplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Temsirolimus (Compound)