DDInter1515 DDInter1376
A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Prednisone {u} (Compound) resembles {v} (Compound) Triamcinolone
Prednisone {u} (Compound) resembles {v} (Compound) Testolactone
Prednisone {u} (Compound) treats {v} (Disease) psoriasis
Prednisone {u} (Compound) binds {v} (Gene) CYP3A4
Prednisone {u} (Compound) upregulates {v} (Gene) VAPB
Prednisone {u} (Compound) palliates {v} (Disease) osteoarthritis
Prednisone {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Prednisone {u} (Compound) downregulates {v} (Gene) ZDHHC6
Prednisone {u} (Compound) causes {v} (Side Effect) Arthralgia
Prednisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Prednisone (Compound) resembles Triamcinolone (Compound)
Prednisone (Compound) resembles Testolactone (Compound)
Prednisone (Compound) treats psoriasis (Disease)
Prednisone (Compound) binds CYP3A4 (Gene)
Prednisone (Compound) upregulates VAPB (Gene)
Prednisone (Compound) palliates osteoarthritis (Disease)
Prednisone (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Prednisone (Compound) downregulates ZDHHC6 (Gene)
Prednisone (Compound) causes Arthralgia (Side Effect)
Prednisone may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide