DDInter458 DDInter598
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxycycline
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tetracycline
Tetracycline {u} (Compound) resembles {v} (Compound) Doxycycline
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Disease) malaria
malaria {u} (Disease) is treated by {v} (Compound) Doxycycline
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rolitetracycline
Rolitetracycline {u} (Compound) resembles {v} (Compound) Doxycycline
Cyclosporine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is downregulated by {v} (Disease) malaria
malaria {u} (Disease) is treated by {v} (Compound) Doxycycline
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Indapamide
Indapamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxycycline
Cyclosporine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Methylergometrine
Methylergometrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxycycline
Cyclosporine {u} (Compound) downregulates {v} (Gene) ADH5
ADH5 {u} (Gene) is downregulated by {v} (Compound) Digitoxin
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxycycline
Cyclosporine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Aminolevulinic acid
Aminolevulinic acid {u} may lead to a major life threatening interaction when taken with {v} Doxycycline
Cyclosporine {u} (Compound) downregulates {v} (Gene) DHFR
DHFR {u} (Gene) is associated with {v} (Disease) malaria
malaria {u} (Disease) is treated by {v} (Compound) Doxycycline
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tetracycline (Compound) and Tetracycline (Compound) resembles Doxycycline (Compound)
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by malaria (Disease) and malaria (Disease) is treated by Doxycycline (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rolitetracycline (Compound) and Rolitetracycline (Compound) resembles Doxycycline (Compound)
Cyclosporine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is downregulated by malaria (Disease) and malaria (Disease) is treated by Doxycycline (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Indapamide (Compound) and Indapamide may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Cyclosporine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Methylergometrine (Compound) and Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline
Cyclosporine (Compound) downregulates ADH5 (Gene) and ADH5 (Gene) is downregulated by Digitoxin (Compound) and Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline
Cyclosporine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Aminolevulinic acid (Compound) and Aminolevulinic acid may lead to a major life threatening interaction when taken with Doxycycline
Cyclosporine (Compound) downregulates DHFR (Gene) and DHFR (Gene) is associated with malaria (Disease) and malaria (Disease) is treated by Doxycycline (Compound)