DDInter720 DDInter535
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Fenoldopam {u} (Compound) upregulates {v} (Gene) MAP7
MAP7 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) upregulates {v} (Gene) MAP7
MAP7 {u} (Gene) regulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) binds {v} (Gene) ADRA2C
ADRA2C {u} (Gene) regulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) upregulates {v} (Gene) MAP7
MAP7 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Fenoldopam {u} (Compound) binds {v} (Gene) ADRA1A
ADRA1A {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Fenoldopam (Compound) upregulates MAP7 (Gene) and MAP7 (Gene) is upregulated by Diazoxide (Compound)
Fenoldopam (Compound) treats hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Fenoldopam (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Diazoxide (Compound)
Fenoldopam (Compound) upregulates MAP7 (Gene) and MAP7 (Gene) regulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Diazoxide (Compound)
Fenoldopam (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Fenoldopam (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Fenoldopam (Compound) binds ADRA2C (Gene) and ADRA2C (Gene) regulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Fenoldopam (Compound) upregulates MAP7 (Gene) and MAP7 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Fenoldopam (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)
Fenoldopam (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)