DDInter336 DDInter645
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Celecoxib {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Enoxaparin
Celecoxib {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Celecoxib {u} (Compound) causes {v} (Side Effect) Haemorrhage intracranial
Haemorrhage intracranial {u} (Side Effect) is caused by {v} (Compound) Fondaparinux
Fondaparinux {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Celecoxib {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is associated with {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Enoxaparin
Celecoxib {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Bismuth subsalicylate
Bismuth subsalicylate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Celecoxib {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Nabumetone
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Celecoxib {u} (Compound) upregulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) covaries with {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Enoxaparin
Celecoxib {u} (Compound) causes {v} (Side Effect) Haemorrhage intracranial
Haemorrhage intracranial {u} (Side Effect) is caused by {v} (Compound) Ticagrelor
Ticagrelor {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Celecoxib {u} (Compound) palliates {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) and {u} (Diease) associated with {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Enoxaparin
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Enoxaparin
Celecoxib (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Celecoxib (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Celecoxib (Compound) causes Haemorrhage intracranial (Side Effect) and Haemorrhage intracranial (Side Effect) is caused by Fondaparinux (Compound) and Fondaparinux may lead to a major life threatening interaction when taken with Enoxaparin
Celecoxib (Compound) palliates rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is associated with MPO (Gene) and MPO (Gene) is bound by Enoxaparin (Compound)
Celecoxib (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Bismuth subsalicylate (Compound) and Bismuth subsalicylate may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Celecoxib (Compound) palliates rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Nabumetone (Compound) and Nabumetone may lead to a major life threatening interaction when taken with Enoxaparin
Celecoxib (Compound) upregulates ERAP2 (Gene) and ERAP2 (Gene) covaries with MPO (Gene) and MPO (Gene) is bound by Enoxaparin (Compound)
Celecoxib (Compound) causes Haemorrhage intracranial (Side Effect) and Haemorrhage intracranial (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may lead to a major life threatening interaction when taken with Enoxaparin
Celecoxib (Compound) palliates hematologic cancer (Disease) and hematologic cancer (Disease) downregulates MPO (Gene) and hematologic cancer (Diease) associated with MPO (Gene) and MPO (Gene) is bound by Enoxaparin (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)