DDInter1763 DDInter489
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Temsirolimus {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Deferiprone
Temsirolimus {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Deferiprone
Temsirolimus {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is regulated by {v} (Gene) BTK
BTK {u} (Gene) is upregulated by {v} (Compound) Deferiprone
Temsirolimus {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Deferiprone
Temsirolimus {u} (Compound) causes {v} (Side Effect) Connective tissue disorder
Connective tissue disorder {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Temsirolimus {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is regulated by {v} (Gene) UGT1A6
UGT1A6 {u} (Gene) is bound by {v} (Compound) Deferiprone
Temsirolimus {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Temsirolimus {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) PHKA1
PHKA1 {u} (Gene) is downregulated by {v} (Compound) Deferiprone
Temsirolimus {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is bound by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Temsirolimus {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) regulates {v} (Gene) LPL
LPL {u} (Gene) is upregulated by {v} (Compound) Deferiprone
Temsirolimus (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Temsirolimus (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Deferiprone (Compound)
Temsirolimus (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is regulated by BTK (Gene) and BTK (Gene) is upregulated by Deferiprone (Compound)
Temsirolimus (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Temsirolimus (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Deferiprone
Temsirolimus (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is regulated by UGT1A6 (Gene) and UGT1A6 (Gene) is bound by Deferiprone (Compound)
Temsirolimus (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Azacitidine (Compound) and Azacitidine may lead to a major life threatening interaction when taken with Deferiprone
Temsirolimus (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by PHKA1 (Gene) and PHKA1 (Gene) is downregulated by Deferiprone (Compound)
Temsirolimus (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is bound by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Deferiprone
Temsirolimus (Compound) downregulates PCNA (Gene) and PCNA (Gene) regulates LPL (Gene) and LPL (Gene) is upregulated by Deferiprone (Compound)