DDInter593 DDInter504
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Desipramine exerts less anticholinergic and sedative side effects compared to tertiary amine TCAs, such as amitriptyline and clomipramine. Desipramine may be used to treat depression, neuropathic pain (unlabeled use), agitation and insomnia (unlabeled use) and attention-deficit hyperactivity disorder (unlabeled use).
Doxepin {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Promazine {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} (Compound) resembles {v} (Compound) Dimetacrine
Dimetacrine {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Protriptyline
Protriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Alimemazine {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} (Compound) resembles {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} (Compound) resembles {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Desipramine
Doxepin {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Desipramine
Doxepin (Compound) resembles Desipramine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Desipramine (Compound)
Doxepin (Compound) resembles Dimetacrine (Compound) and Dimetacrine (Compound) resembles Desipramine (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Desipramine (Compound)
Doxepin may cause a minor interaction that can limit clinical effects when taken with Atomoxetine and Atomoxetine (Compound) resembles Desipramine (Compound)
Doxepin (Compound) resembles Alimemazine (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Desipramine (Compound)
Doxepin (Compound) resembles Amitriptyline (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Desipramine (Compound)
Doxepin (Compound) resembles Imipramine (Compound) and Imipramine (Compound) resembles Desipramine (Compound)
Doxepin (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Desipramine (Compound)
Doxepin (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Desipramine (Compound)