DDInter1619 DDInter1155
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Mepyramine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) resembles {v} (Compound) Mepyramine
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Mepyramine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Ipratropium
Ipratropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Mepyramine
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Fluoxetine
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Mepyramine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is regulated by {v} (Gene) SLC22A4
SLC22A4 {u} (Gene) is bound by {v} (Compound) Mepyramine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Cyclizine
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Ropinirole {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Mepyramine
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Mepyramine (Compound)
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ipratropium (Compound) and Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Mepyramine (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Fluoxetine (Compound) and Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Mepyramine (Compound)
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is regulated by SLC22A4 (Gene) and SLC22A4 (Gene) is bound by Mepyramine (Compound)
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Cyclizine (Compound) and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Ropinirole (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Mepyramine (Compound)