DDInter554 DDInter1938
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digitalis_ plant, studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Digoxin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vincristine
Digoxin {u} (Compound) upregulates {v} (Gene) TICAM1
TICAM1 {u} (Gene) is upregulated by {v} (Compound) Vincristine
Digoxin {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Digoxin {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is downregulated by {v} (Compound) Vincristine
Digoxin {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) ATP1B1
ATP1B1 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Digoxin {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Vincristine
Digoxin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Digoxin {u} (Compound) binds {v} (Gene) ABCB11
ABCB11 {u} (Gene) is bound by {v} (Compound) Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Digoxin {u} (Compound) upregulates {v} (Gene) TICAM1
TICAM1 {u} (Gene) is upregulated by {v} (Compound) Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Digoxin {u} (Compound) upregulates {v} (Gene) PLAUR
PLAUR {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Digoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vincristine (Compound)
Digoxin (Compound) upregulates TICAM1 (Gene) and TICAM1 (Gene) is upregulated by Vincristine (Compound)
Digoxin (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Vincristine (Compound)
Digoxin (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is downregulated by Vincristine (Compound)
Digoxin (Compound) binds ATP1B1 (Gene) and Digoxin (Compound) upregulates ATP1B1 (Gene) and ATP1B1 (Gene) is downregulated by Vincristine (Compound)
Digoxin (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Vincristine (Compound)
Digoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinorelbine (Compound) and Vinorelbine (Compound) resembles Vincristine (Compound)
Digoxin (Compound) binds ABCB11 (Gene) and ABCB11 (Gene) is bound by Vinblastine (Compound) and Vinblastine (Compound) resembles Vincristine (Compound)
Digoxin (Compound) upregulates TICAM1 (Gene) and TICAM1 (Gene) is upregulated by Vinorelbine (Compound) and Vinorelbine (Compound) resembles Vincristine (Compound)
Digoxin (Compound) upregulates PLAUR (Gene) and PLAUR (Gene) is upregulated by Vinblastine (Compound) and Vinblastine (Compound) resembles Vincristine (Compound)