DDInter1834 DDInter459
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Cyproheptadine
Topiramate {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is associated with {v} (Gene) HTR1A
HTR1A {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Topiramate {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Cyproheptadine
Topiramate {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Topiramate {u} (Compound) causes {v} (Side Effect) Increased appetite
Increased appetite {u} (Side Effect) is caused by {v} (Compound) Ketotifen
Ketotifen {u} (Compound) resembles {v} (Compound) Cyproheptadine
Topiramate {u} (Compound) causes {v} (Side Effect) Euphoric mood
Euphoric mood {u} (Side Effect) is caused by {v} (Compound) Tolcapone
Tolcapone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Cyproheptadine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Azatadine
Azatadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Cyproheptadine
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Cyproheptadine (Compound)
Topiramate (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Cyproheptadine (Compound)
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is associated with HTR1A (Gene) and HTR1A (Gene) is bound by Cyproheptadine (Compound)
Topiramate (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Cyproheptadine (Compound)
Topiramate (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Topiramate (Compound) causes Increased appetite (Side Effect) and Increased appetite (Side Effect) is caused by Ketotifen (Compound) and Ketotifen (Compound) resembles Cyproheptadine (Compound)
Topiramate (Compound) causes Euphoric mood (Side Effect) and Euphoric mood (Side Effect) is caused by Tolcapone (Compound) and Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Cyproheptadine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Azatadine (Compound) and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Cyproheptadine (Compound)