DDInter624 DDInter1263
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Efavirenz {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Naltrexone
Efavirenz {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Naltrexone
Efavirenz {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Efavirenz {u} (Compound) causes {v} (Side Effect) Dyspnoea
Dyspnoea {u} (Side Effect) is caused by {v} (Compound) Oxycodone
Oxycodone {u} may lead to a major life threatening interaction when taken with {v} Naltrexone
Efavirenz {u} (Compound) causes {v} (Side Effect) Suicidal ideation
Suicidal ideation {u} (Side Effect) is caused by {v} (Compound) Acitretin
Acitretin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Efavirenz {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Butorphanol
Butorphanol {u} (Compound) resembles {v} (Compound) Naltrexone
Efavirenz {u} (Compound) causes {v} (Side Effect) Pregnancy
Pregnancy {u} (Side Effect) is caused by {v} (Compound) Captopril
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Efavirenz {u} (Compound) causes {v} (Side Effect) Menopausal symptoms
Menopausal symptoms {u} (Side Effect) is caused by {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Naltrexone
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) TGFBR2
TGFBR2 {u} (Gene) is upregulated by {v} (Compound) Naltrexone
Efavirenz {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Naltrexone
Efavirenz (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Naltrexone (Compound)
Efavirenz (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Naltrexone (Compound)
Efavirenz (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Naltrexone (Compound)
Efavirenz (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Oxycodone (Compound) and Oxycodone may lead to a major life threatening interaction when taken with Naltrexone
Efavirenz (Compound) causes Suicidal ideation (Side Effect) and Suicidal ideation (Side Effect) is caused by Acitretin (Compound) and Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Efavirenz (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Butorphanol (Compound) and Butorphanol (Compound) resembles Naltrexone (Compound)
Efavirenz (Compound) causes Pregnancy (Side Effect) and Pregnancy (Side Effect) is caused by Captopril (Compound) and Captopril may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Efavirenz (Compound) causes Menopausal symptoms (Side Effect) and Menopausal symptoms (Side Effect) is caused by Hydrocodone (Compound) and Hydrocodone (Compound) resembles Naltrexone (Compound)
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates TGFBR2 (Gene) and TGFBR2 (Gene) is upregulated by Naltrexone (Compound)
Efavirenz (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Naltrexone (Compound)