DDInter1397 DDInter899
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Paroxetine {u} (Compound) binds {v} (Gene) CHRM5
Paroxetine {u} (Compound) upregulates {v} (Gene) CSTA
Paroxetine {u} (Compound) palliates {v} (Disease) panic disorder
Paroxetine {u} (Compound) downregulates {v} (Gene) GRWD1
Paroxetine {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Paroxetine (Compound) binds CHRM5 (Gene)
Paroxetine (Compound) upregulates CSTA (Gene)
Paroxetine (Compound) palliates panic disorder (Disease)
Paroxetine (Compound) downregulates GRWD1 (Gene)
Paroxetine (Compound) causes Anaphylactoid reaction (Side Effect)