DDInter268 DDInter1223
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced by solvent extraction, catalytic hydrotreating, or hydrocracking. Unrefined or mildly treated mineral oils are classified as Group 3 carcinogens by the World Health Organizations, as chronic exposure to these aromatics including alkylated polycyclic aromatic compounds (PAC) can lead to skin cancer. Mineral oil is a common ingredient in baby lotions, cold creams, ointments and cosmetics to treat and prevent dry, rough, scaly, itchy skin and minor skin irritations. It is also used as a mild laxative for human or veterinary uses.
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bendroflumethiazide
Bendroflumethiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Phylloquinone
Phylloquinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mineral oil
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may lead to a major life threatening interaction when taken with {v} Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Phylloquinone
Phylloquinone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mineral oil
Calcitriol {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Triamcinolone
Triamcinolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metolazone
Metolazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mineral oil
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Phylloquinone (Compound) and Phylloquinone may cause a minor interaction that can limit clinical effects when taken with Mineral oil
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may lead to a major life threatening interaction when taken with Calcifediol and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol (Compound) resembles Calcifediol (Compound) and Cholecalciferol may lead to a major life threatening interaction when taken with Calcifediol and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Phylloquinone (Compound) and Phylloquinone may cause a minor interaction that can limit clinical effects when taken with Mineral oil
Calcitriol (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Triamcinolone (Compound) and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol (Compound) resembles Cholecalciferol (Compound) and Calcifediol may lead to a major life threatening interaction when taken with Cholecalciferol and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil