DDInter535 DDInter1125
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Diazoxide {u} (Compound) causes {v} (Side Effect) Herpes virus infection
Herpes virus infection {u} (Side Effect) is caused by {v} (Compound) Maraviroc
Diazoxide {u} (Compound) causes {v} (Side Effect) Herpes virus infection
Herpes virus infection {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Maraviroc
Diazoxide {u} (Compound) causes {v} (Side Effect) Herpes virus infection
Herpes virus infection {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Minoxidil
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Diazoxide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Diazoxide {u} (Compound) binds {v} (Gene) ATP1A1
ATP1A1 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Diazoxide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Maraviroc
Diazoxide {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Maraviroc
Diazoxide {u} (Compound) upregulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Ponatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maraviroc
Diazoxide (Compound) causes Herpes virus infection (Side Effect) and Herpes virus infection (Side Effect) is caused by Maraviroc (Compound)
Diazoxide (Compound) causes Herpes virus infection (Side Effect) and Herpes virus infection (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Maraviroc (Compound)
Diazoxide (Compound) causes Herpes virus infection (Side Effect) and Herpes virus infection (Side Effect) is caused by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Minoxidil (Compound) and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Diazoxide (Compound) binds CA2 (Gene) and CA2 (Gene) is bound by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Diazoxide (Compound) binds ATP1A1 (Gene) and ATP1A1 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc
Diazoxide (Compound) binds CA2 (Gene) and CA2 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Maraviroc (Compound)
Diazoxide (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Maraviroc
Diazoxide (Compound) upregulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Ponatinib (Compound) and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Maraviroc