DDInter1537 DDInter690
Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Bupropion {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine {u} (Compound) resembles {v} (Compound) Diltiazem
Diltiazem {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine {u} may lead to a major life threatening interaction when taken with {v} Morphine
Morphine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine {u} (Compound) binds {v} (Gene) DRD4
DRD4 {u} (Gene) interacts with {v} (Gene) GABRA1
GABRA1 {u} (Gene) is bound by {v} (Compound) Ethanol
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Propiomazine (Compound) resembles Methadone (Compound) and Methadone (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Propiomazine may lead to a major life threatening interaction when taken with Bupropion and Bupropion (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Propiomazine (Compound) resembles Diltiazem (Compound) and Diltiazem (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Propiomazine may lead to a major life threatening interaction when taken with Morphine and Morphine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Propiomazine (Compound) binds DRD4 (Gene) and DRD4 (Gene) interacts with GABRA1 (Gene) and GABRA1 (Gene) is bound by Ethanol (Compound)