DDInter1913 DDInter1141
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects of khelline when he found that all of his samples, dissolved in valproic acid, exerted a similar degree of anticonvulsive activity. It first received approval on February 28, 1978 from the FDA under the trade name Depakene. Since then, it has been investigated for neuroprotective, anti-manic, and anti-migraine effects. It is currently a compound of interest in the field of oncology for its anti-proliferative effects and is the subject of many clinical trials in a variety of cancer types.
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} (Compound) causes {v} (Side Effect) Photophobia
Photophobia {u} (Side Effect) is caused by {v} (Compound) Difluprednate
Difluprednate {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Dydrogesterone
Dydrogesterone {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) binds {v} (Gene) PGR
PGR {u} (Gene) is bound by {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) palliates {v} (Disease) breast cancer
breast cancer {u} (Disease) is palliated by {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Interferon beta-1a
Interferon beta-1a {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxymesterone
Fluoxymesterone {u} (Compound) resembles {v} (Compound) Megestrol acetate
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) is included by {v} (Pharmacologic Class) Progesterone Congeners
Progesterone Congeners {u} (Pharmacologic Class) includes {v} (Compound) Megestrol acetate
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) resembles Megestrol acetate (Compound)
Valproic acid (Compound) causes Photophobia (Side Effect) and Photophobia (Side Effect) is caused by Difluprednate (Compound) and Difluprednate (Compound) resembles Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) resembles Dydrogesterone (Compound) and Dydrogesterone (Compound) resembles Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) resembles Megestrol acetate (Compound)
Valproic acid (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Methyltestosterone (Compound) and Methyltestosterone (Compound) resembles Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) resembles Testosterone (Compound) and Testosterone (Compound) resembles Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) binds PGR (Gene) and PGR (Gene) is bound by Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is palliated by Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Megestrol acetate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) is included by Progesterone Congeners (Pharmacologic Class) and Progesterone Congeners (Pharmacologic Class) includes Megestrol acetate (Compound)