DDInter1759 DDInter856
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Telmisartan {u} (Compound) resembles {v} (Compound) Candesartan
Telmisartan {u} (Compound) treats {v} (Disease) hypertension
Telmisartan {u} (Compound) binds {v} (Gene) ABCG2
Telmisartan {u} (Compound) is included by {v} (Pharmacologic Class) Angiotensin 2 Receptor Antagonists
Telmisartan {u} (Compound) causes {v} (Side Effect) Cerebrovascular disorder
Telmisartan (Compound) resembles Candesartan (Compound)
Telmisartan (Compound) treats hypertension (Disease)
Telmisartan (Compound) binds ABCG2 (Gene)
Telmisartan (Compound) is included by Angiotensin 2 Receptor Antagonists (Pharmacologic Class)
Telmisartan (Compound) causes Cerebrovascular disorder (Side Effect)