DDInter246 DDInter1435
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Budesonide {u} (Compound) resembles {v} (Compound) Flurandrenolide
Budesonide {u} (Compound) treats {v} (Disease) asthma
Budesonide {u} (Compound) binds {v} (Gene) CYP3A4
Budesonide {u} (Compound) upregulates {v} (Gene) P4HA2
Budesonide {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Budesonide {u} (Compound) downregulates {v} (Gene) RAP1GAP
Budesonide {u} (Compound) causes {v} (Side Effect) Pain
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Isoprenaline
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipilimumab
Budesonide (Compound) resembles Flurandrenolide (Compound)
Budesonide (Compound) treats asthma (Disease)
Budesonide (Compound) binds CYP3A4 (Gene)
Budesonide (Compound) upregulates P4HA2 (Gene)
Budesonide (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Budesonide (Compound) downregulates RAP1GAP (Gene)
Budesonide (Compound) causes Pain (Side Effect)
Budesonide may cause a minor interaction that can limit clinical effects when taken with Isoprenaline
Budesonide may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab