DDInter1079 DDInter1376
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Lisinopril was granted FDA approval on 29 December 1987.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Lisinopril {u} (Compound) resembles {v} (Compound) Enalapril
Lisinopril {u} (Compound) resembles {v} (Compound) Trandolapril
Lisinopril {u} (Compound) treats {v} (Disease) hypertension
Lisinopril {u} (Compound) binds {v} (Gene) ABCB1
Lisinopril {u} (Compound) downregulates {v} (Gene) ALAS1
Lisinopril {u} (Compound) causes {v} (Side Effect) Inappropriate antidiuretic hormone secretion
Lisinopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Lisinopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Erythropoietin
Lisinopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idelalisib
Lisinopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urokinase
Lisinopril (Compound) resembles Enalapril (Compound)
Lisinopril (Compound) resembles Trandolapril (Compound)
Lisinopril (Compound) treats hypertension (Disease)
Lisinopril (Compound) binds ABCB1 (Gene)
Lisinopril (Compound) downregulates ALAS1 (Gene)
Lisinopril (Compound) causes Inappropriate antidiuretic hormone secretion (Side Effect)
Lisinopril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Lisinopril may cause a minor interaction that can limit clinical effects when taken with Erythropoietin
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Urokinase