DDInter948 DDInter1509
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991. Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.
Pravastatin {u} (Compound) resembles {v} (Compound) Lovastatin
Pravastatin {u} (Compound) treats {v} (Disease) atherosclerosis
Pravastatin {u} (Compound) binds {v} (Gene) CYP2C9
Pravastatin {u} (Compound) upregulates {v} (Gene) CEBPZ
Pravastatin {u} (Compound) downregulates {v} (Gene) SPRED2
Pravastatin {u} (Compound) causes {v} (Side Effect) Vascular purpura
Pravastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Pravastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epirubicin
Pravastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Asparaginase Escherichia coli
Pravastatin {u} may lead to a major life threatening interaction when taken with {v} Teriflunomide
Pravastatin (Compound) resembles Lovastatin (Compound)
Pravastatin (Compound) treats atherosclerosis (Disease)
Pravastatin (Compound) binds CYP2C9 (Gene)
Pravastatin (Compound) upregulates CEBPZ (Gene)
Pravastatin (Compound) downregulates SPRED2 (Gene)
Pravastatin (Compound) causes Vascular purpura (Side Effect)
Pravastatin may cause a minor interaction that can limit clinical effects when taken with Warfarin
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli
Pravastatin may lead to a major life threatening interaction when taken with Teriflunomide