DDInter1879 DDInter1960
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Triprolidine {u} (Compound) resembles {v} (Compound) Eperisone
Triprolidine {u} (Compound) resembles {v} (Compound) Cloperastine
Triprolidine {u} (Compound) binds {v} (Gene) CYP2D6
Triprolidine {u} (Compound) upregulates {v} (Gene) NFKBIA
Triprolidine {u} (Compound) palliates {v} (Disease) atopic dermatitis
Triprolidine {u} (Compound) downregulates {v} (Gene) RAP1GAP
Triprolidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Triprolidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxazepam
Triprolidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Secobarbital
Triprolidine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Triprolidine (Compound) resembles Eperisone (Compound)
Triprolidine (Compound) resembles Cloperastine (Compound)
Triprolidine (Compound) binds CYP2D6 (Gene)
Triprolidine (Compound) upregulates NFKBIA (Gene)
Triprolidine (Compound) palliates atopic dermatitis (Disease)
Triprolidine (Compound) downregulates RAP1GAP (Gene)
Triprolidine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Oxazepam
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital
Triprolidine may lead to a major life threatening interaction when taken with Zonisamide