DDInter458 DDInter1004
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate.
Cyclosporine {u} (Compound) upregulates {v} (Gene) DHDDS
DHDDS {u} (Gene) is upregulated by {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephrotoxicity
Nephrotoxicity {u} (Side Effect) is caused by {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) upregulates {v} (Gene) DHDDS
DHDDS {u} (Gene) is regulated by {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephrotoxicity
Nephrotoxicity {u} (Side Effect) is caused by {v} (Compound) Tobramycin
Tobramycin {u} (Compound) resembles {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Azotaemia
Azotaemia {u} (Side Effect) is caused by {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Kanamycin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kanamycin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Tinnitus
Tinnitus {u} (Side Effect) is caused by {v} (Compound) Nadolol
Nadolol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kanamycin
Cyclosporine (Compound) upregulates DHDDS (Gene) and DHDDS (Gene) is upregulated by Kanamycin (Compound)
Cyclosporine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Kanamycin (Compound)
Cyclosporine (Compound) causes Nephrotoxicity (Side Effect) and Nephrotoxicity (Side Effect) is caused by Kanamycin (Compound)
Cyclosporine (Compound) upregulates DHDDS (Gene) and DHDDS (Gene) is regulated by SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Kanamycin (Compound)
Cyclosporine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Kanamycin (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by PUF60 (Gene) and PUF60 (Gene) is downregulated by Kanamycin (Compound)
Cyclosporine (Compound) causes Nephrotoxicity (Side Effect) and Nephrotoxicity (Side Effect) is caused by Tobramycin (Compound) and Tobramycin (Compound) resembles Kanamycin (Compound)
Cyclosporine (Compound) causes Azotaemia (Side Effect) and Azotaemia (Side Effect) is caused by Amikacin (Compound) and Amikacin (Compound) resembles Kanamycin (Compound)
Cyclosporine (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin
Cyclosporine (Compound) causes Tinnitus (Side Effect) and Tinnitus (Side Effect) is caused by Nadolol (Compound) and Nadolol may cause a minor interaction that can limit clinical effects when taken with Kanamycin