DDInter1118 DDInter1658
Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially as a fire retardant. It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers).
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Magnesium hydroxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quazepam
Magnesium hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenamide
Magnesium hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Deutetrabenazine
Magnesium hydroxide {u} may lead to a major life threatening interaction when taken with {v} Erdafitinib
Magnesium hydroxide {u} may lead to a major life threatening interaction when taken with {v} Tolevamer
Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Quazepam
Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide
Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Magnesium hydroxide may lead to a major life threatening interaction when taken with Erdafitinib
Magnesium hydroxide may lead to a major life threatening interaction when taken with Tolevamer