DDInter458 DDInter1568
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as Zantac, and is available in various forms, including tablet, injection, and effervescent tablet preparations.[L10818,F4253] The prevalence of GERD is thought to be 10-20% in western countries. Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of gastric acid associated conditions and is therefore widely used in GERD and other gastric-acid related conditions.[A176849,L10818]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) downregulates {v} (Gene) POP4
POP4 {u} (Gene) is upregulated by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) upregulates {v} (Gene) RPN1
RPN1 {u} (Gene) is downregulated by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nelfinavir
Nelfinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ranitidine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nizatidine
Nizatidine {u} (Compound) resembles {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) downregulates {v} (Gene) POP4
POP4 {u} (Gene) is regulated by {v} (Gene) RPN1
RPN1 {u} (Gene) is downregulated by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ranitidine
Cyclosporine {u} (Compound) upregulates {v} (Gene) RPN1
RPN1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ranitidine
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ranitidine (Compound)
Cyclosporine (Compound) downregulates POP4 (Gene) and POP4 (Gene) is upregulated by Ranitidine (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Ranitidine (Compound)
Cyclosporine (Compound) upregulates RPN1 (Gene) and RPN1 (Gene) is downregulated by Ranitidine (Compound)
Cyclosporine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Ranitidine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nelfinavir (Compound) and Nelfinavir may cause a minor interaction that can limit clinical effects when taken with Ranitidine
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nizatidine (Compound) and Nizatidine (Compound) resembles Ranitidine (Compound)
Cyclosporine (Compound) downregulates POP4 (Gene) and POP4 (Gene) is regulated by RPN1 (Gene) and RPN1 (Gene) is downregulated by Ranitidine (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Ranitidine (Compound)
Cyclosporine (Compound) upregulates RPN1 (Gene) and RPN1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Ranitidine (Compound)