DDInter385 DDInter1662
In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Cisapride {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Cisapride {u} (Compound) downregulates {v} (Gene) VAT1
VAT1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Cisapride {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Sertraline
Cisapride {u} (Compound) downregulates {v} (Gene) VAT1
VAT1 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Cisapride {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Sertraline
Cisapride {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Sertraline
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Cisapride may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Cisapride (Compound) downregulates VAT1 (Gene) and VAT1 (Gene) is upregulated by Sertraline (Compound)
Cisapride may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Cisapride (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Cisapride (Compound) resembles Metoclopramide (Compound) and Metoclopramide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Sertraline (Compound)
Cisapride (Compound) downregulates VAT1 (Gene) and VAT1 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Sertraline (Compound)
Cisapride (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with schizophrenia (Disease) and schizophrenia (Disease) is palliated by Sertraline (Compound)
Cisapride (Compound) resembles Trimethobenzamide (Compound) and Trimethobenzamide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Sertraline (Compound)
Cisapride (Compound) resembles Metoclopramide (Compound) and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)