DDInter258 DDInter448
A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers robust effectiveness in treating NSCLC in patients with this type of rearrangement. Crizotinib was the first-in-class drug used to treat ALK-positive tumors. Second- and third-generation ALK-tyrosine kinase-inhibitors have overcome many of the pharmacodynamic and genetic resistance mechanisms crizotinib is prone to. Crizotinib was approved by the FDA in 2011, and its use is accompanied by FDA-approved tests used to detect ALK and ROS1 rearrangements.
Butorphanol {u} (Compound) causes {v} (Side Effect) Respiratory failure
Respiratory failure {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Butorphanol {u} (Compound) resembles {v} (Compound) Naltrexone
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Crizotinib
Butorphanol {u} (Compound) causes {v} (Side Effect) Respiratory failure
Respiratory failure {u} (Side Effect) is caused by {v} (Compound) Gefitinib
Gefitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Crizotinib
Butorphanol {u} (Compound) causes {v} (Side Effect) Visual impairment
Visual impairment {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Crizotinib
Butorphanol {u} (Compound) causes {v} (Side Effect) Upper respiratory tract infection
Upper respiratory tract infection {u} (Side Effect) is caused by {v} (Compound) Mirabegron
Mirabegron {u} may cause a minor interaction that can limit clinical effects when taken with {v} Crizotinib
Butorphanol {u} (Compound) resembles {v} (Compound) Dezocine
Dezocine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palonosetron
Palonosetron {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Butorphanol {u} (Compound) resembles {v} (Compound) Naltrexone
Naltrexone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Crizotinib
Butorphanol {u} (Compound) resembles {v} (Compound) Pentazocine
Pentazocine {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Butorphanol {u} (Compound) resembles {v} (Compound) Dezocine
Dezocine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Crizotinib
Butorphanol {u} (Compound) resembles {v} (Compound) Naltrexone
Naltrexone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Crizotinib
Butorphanol (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Crizotinib (Compound)
Butorphanol (Compound) resembles Naltrexone (Compound) and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib
Butorphanol (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib
Butorphanol (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Crizotinib
Butorphanol (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Mirabegron (Compound) and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Crizotinib
Butorphanol (Compound) resembles Dezocine (Compound) and Dezocine may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and Palonosetron may lead to a major life threatening interaction when taken with Crizotinib
Butorphanol (Compound) resembles Naltrexone (Compound) and Naltrexone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Crizotinib (Compound)
Butorphanol (Compound) resembles Pentazocine (Compound) and Pentazocine (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Crizotinib (Compound)
Butorphanol (Compound) resembles Dezocine (Compound) and Dezocine may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib
Butorphanol (Compound) resembles Naltrexone (Compound) and Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Crizotinib (Compound)