DDInter535 DDInter349
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
Diazoxide {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Chlorpheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabilone
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) palliates {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Phentolamine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bupropion
Bupropion {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Phentolamine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) palliates {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Minoxidil
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Dextromethorphan
Dextromethorphan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Mepyramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloral hydrate
Diazoxide (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Chlorpheniramine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Morphine (Compound) and Morphine may lead to a major life threatening interaction when taken with Chloral hydrate
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) palliates hypertension (Disease) and hypertension (Disease) is palliated by Phentolamine (Compound) and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Phentolamine (Compound) and Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) palliates hypertension (Disease) and hypertension (Disease) is treated by Minoxidil (Compound) and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Dextromethorphan (Compound) and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate