DDInter431 DDInter1763
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Colchicine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Colchicine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Colchicine {u} (Compound) upregulates {v} (Gene) CDH3
CDH3 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Colchicine {u} (Compound) downregulates {v} (Gene) WDR5B
WDR5B {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Colchicine {u} (Compound) upregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Colchicine {u} (Compound) downregulates {v} (Gene) MPC2
MPC2 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Colchicine {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Colchicine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Colchicine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Colchicine {u} (Compound) upregulates {v} (Gene) CDH3
CDH3 {u} (Gene) is downregulated by {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Temsirolimus
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Colchicine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Colchicine (Compound) upregulates CDH3 (Gene) and CDH3 (Gene) is upregulated by Temsirolimus (Compound)
Colchicine (Compound) downregulates WDR5B (Gene) and WDR5B (Gene) is upregulated by Temsirolimus (Compound)
Colchicine (Compound) upregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Temsirolimus (Compound)
Colchicine (Compound) downregulates MPC2 (Gene) and MPC2 (Gene) is downregulated by Temsirolimus (Compound)
Colchicine (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Temsirolimus (Compound)
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Colchicine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Colchicine (Compound) upregulates CDH3 (Gene) and CDH3 (Gene) is downregulated by kidney cancer (Disease) and kidney cancer (Disease) is treated by Temsirolimus (Compound)