DDInter1860 DDInter593
Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], [imipramine], [nortriptyline], [protriptyline] and [trimipramine]. Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant. However, in 2010 it was approved for the treatment of insomnia. The latter indication was presented by Pernix Therapeutics.
Triazolam {u} (Compound) resembles {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) resembles {v} (Compound) Doxepin
Triazolam {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Doxepin
Triazolam {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Doxepin
Triazolam {u} (Compound) resembles {v} (Compound) Halazepam
Halazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Triazolam {u} (Compound) resembles {v} (Compound) Estazolam
Estazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Triazolam {u} (Compound) resembles {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) resembles {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Triazolam {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Triazolam {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Thiothixene {u} (Compound) resembles {v} (Compound) Doxepin
Triazolam {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Triazolam {u} (Compound) causes {v} (Side Effect) Drug withdrawal syndrome
Drug withdrawal syndrome {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Doxepin
Triazolam (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Doxepin (Compound)
Triazolam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound)
Triazolam (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Doxepin (Compound)
Triazolam (Compound) resembles Halazepam (Compound) and Halazepam may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Triazolam (Compound) resembles Estazolam (Compound) and Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Triazolam (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Triazolam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Triazolam (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Thiothixene (Compound) and Thiothixene (Compound) resembles Doxepin (Compound)
Triazolam (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Triazolam (Compound) causes Drug withdrawal syndrome (Side Effect) and Drug withdrawal syndrome (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Doxepin (Compound)