DDInter576 DDInter1491
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) downregulates {v} (Gene) JADE2
JADE2 {u} (Gene) is upregulated by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Thalidomide
Thalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Thalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) TNF
TNF {u} (Gene) is bound by {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) upregulates {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) interacts with {v} (Gene) TNF
TNF {u} (Gene) is bound by {v} (Compound) Pomalidomide
Disulfiram {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) TNF
TNF {u} (Gene) is bound by {v} (Compound) Pomalidomide
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pomalidomide (Compound)
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Pomalidomide (Compound)
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Pomalidomide (Compound)
Disulfiram (Compound) downregulates JADE2 (Gene) and JADE2 (Gene) is upregulated by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Pomalidomide (Compound)
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound) and Thalidomide (Compound) resembles Pomalidomide (Compound)
Disulfiram (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound) and Thalidomide (Compound) resembles Pomalidomide (Compound)
Disulfiram (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Pomalidomide (Compound)
Disulfiram (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by TNF (Gene) and TNF (Gene) is bound by Pomalidomide (Compound)
Disulfiram (Compound) upregulates TNFAIP3 (Gene) and TNFAIP3 (Gene) interacts with TNF (Gene) and TNF (Gene) is bound by Pomalidomide (Compound)
Disulfiram (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by TNF (Gene) and TNF (Gene) is bound by Pomalidomide (Compound)