DDInter1642 DDInter1144
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem cell transplant. It is also used to treat uveal melanoma with unresectable hepatic metastases.
Melphalan {u} (Compound) resembles {v} (Compound) L-Phenylalanine
Melphalan {u} (Compound) resembles {v} (Compound) Levodopa
Melphalan {u} (Compound) treats {v} (Disease) ovarian cancer
Melphalan {u} (Compound) binds {v} (Gene) SLC7A5
Melphalan {u} (Compound) upregulates {v} (Gene) DDB2
Melphalan {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Melphalan {u} (Compound) causes {v} (Side Effect) Radiation myelopathy
Melphalan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Melphalan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Efalizumab
Melphalan (Compound) resembles L-Phenylalanine (Compound)
Melphalan (Compound) resembles Levodopa (Compound)
Melphalan (Compound) treats ovarian cancer (Disease)
Melphalan (Compound) binds SLC7A5 (Gene)
Melphalan (Compound) upregulates DDB2 (Gene)
Melphalan (Compound) is included by Alkylating Activity (Pharmacologic Class)
Melphalan (Compound) causes Radiation myelopathy (Side Effect)
Melphalan may cause a minor interaction that can limit clinical effects when taken with Norfloxacin
Melphalan may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab