DDInter1834 DDInter1155
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) resembles {v} (Compound) Mepyramine
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) resembles {v} (Compound) Mepyramine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Ipratropium
Ipratropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Mepyramine
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Mepyramine
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Fluoxetine
Fluoxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Cyclizine
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Topiramate {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Mepyramine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) covaries with {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Mepyramine
Topiramate {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Chloropyramine (Compound) and Chloropyramine (Compound) resembles Mepyramine (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ipratropium (Compound) and Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Mepyramine (Compound)
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Mepyramine (Compound)
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Fluoxetine (Compound) and Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Cyclizine (Compound) and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Topiramate (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Mepyramine (Compound)
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) covaries with PAK1 (Gene) and PAK1 (Gene) is upregulated by Mepyramine (Compound)
Topiramate (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine