DDInter1822 DDInter1713
Aminoglycosides, many of which are derived directly from _Streptomyces_ spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics.[A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.[L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.[A232294, A232349, L
Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity.[A233325,A232294] Although streptomycin was the first antibiotic determined to be effective against mycobacterium tuberculosis, it has fallen out of favor due to resistance and is now primarily used as adjunctive treatment in cases of multi-drug resistant tuberculosis.
Tobramycin {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Streptomycin
Tobramycin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Streptomycin
Tobramycin {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Streptomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Neomycin
Neomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Streptomycin
Tobramycin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Streptomycin
Tobramycin {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Ceftaroline fosamil
Ceftaroline fosamil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Tobramycin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Streptomycin
Tobramycin {u} (Compound) causes {v} (Side Effect) Renal impairment
Renal impairment {u} (Side Effect) is caused by {v} (Compound) Etodolac
Etodolac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Tobramycin (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Streptomycin (Compound)
Tobramycin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Streptomycin (Compound)
Tobramycin (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Tobramycin (Compound) resembles Neomycin (Compound) and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Tobramycin (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) resembles Streptomycin (Compound) and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Tobramycin (Compound) resembles Amikacin (Compound) and Amikacin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Streptomycin (Compound)
Tobramycin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Amikacin (Compound) and Amikacin (Compound) resembles Streptomycin (Compound)
Tobramycin (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Ceftaroline fosamil (Compound) and Ceftaroline fosamil may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Tobramycin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Amikacin (Compound) and Amikacin (Compound) resembles Streptomycin (Compound)
Tobramycin (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Etodolac (Compound) and Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin