DDInter601 DDInter1747
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. Due to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Dronabinol {u} (Compound) resembles {v} (Compound) Nabilone
Dronabinol {u} (Compound) binds {v} (Gene) CNR1
Dronabinol {u} (Compound) is included by {v} (Pharmacologic Class) Cannabinoids
Dronabinol {u} (Compound) causes {v} (Side Effect) Sinusitis
Dronabinol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delavirdine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nifedipine
Dronabinol {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Dronabinol {u} may lead to a major life threatening interaction when taken with {v} Tramadol
Dronabinol (Compound) resembles Nabilone (Compound)
Dronabinol (Compound) binds CNR1 (Gene)
Dronabinol (Compound) is included by Cannabinoids (Pharmacologic Class)
Dronabinol (Compound) causes Sinusitis (Side Effect)
Dronabinol may cause a minor interaction that can limit clinical effects when taken with Delavirdine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine
Dronabinol may lead to a major life threatening interaction when taken with Iohexol
Dronabinol may lead to a major life threatening interaction when taken with Tramadol