DDInter1570 DDInter212
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956 but has been used as a laxative since 1952.
Ranolazine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is regulated by {v} (Gene) KTN1
KTN1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) GPR55
GPR55 {u} (Gene) is bound by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) downregulates {v} (Gene) SDHB
SDHB {u} (Gene) is regulated by {v} (Gene) FBXL12
FBXL12 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Dronedarone
Dronedarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisacodyl
Ranolazine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Bisacodyl
Ranolazine {u} (Compound) resembles {v} (Compound) Guaifenesin
Guaifenesin {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Ranolazine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Bisacodyl (Compound)
Ranolazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Bisacodyl (Compound)
Ranolazine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is downregulated by Bisacodyl (Compound)
Ranolazine (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Ranolazine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is regulated by KTN1 (Gene) and KTN1 (Gene) is upregulated by Bisacodyl (Compound)
Ranolazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by GPR55 (Gene) and GPR55 (Gene) is bound by Bisacodyl (Compound)
Ranolazine (Compound) downregulates SDHB (Gene) and SDHB (Gene) is regulated by FBXL12 (Gene) and FBXL12 (Gene) is upregulated by Bisacodyl (Compound)
Ranolazine (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Dronedarone (Compound) and Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Ranolazine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Ranolazine (Compound) resembles Guaifenesin (Compound) and Guaifenesin (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Bisacodyl (Compound)