DDInter834 DDInter1544
Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its indication as an adjunct therapy in the treatment of peptic ulcers.[A233570,L33090] Later research, taking advantage of the systemic distribution of muscarinic receptors through the body, found that glycopyrronium could also be used for reducing sweat gland, oral, airway, and gastric secretions; as well as reducing cardiac inhibitory reflexes; and reducing bronchoconstriction in COPD. Glycopyrronium is commonly prescribed as a first line treatment for a wide variety indications and is considered to have a wider therapeutic window than [tiotropium]. Glycopy
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Glycopyrronium {u} (Compound) resembles {v} (Compound) Hexylcaine
Glycopyrronium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Glycopyrronium {u} (Compound) resembles {v} (Compound) Oxybutynin
Glycopyrronium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Glycopyrronium {u} (Compound) binds {v} (Gene) CHRM3
Glycopyrronium {u} (Compound) downregulates {v} (Gene) TIMM9
Glycopyrronium {u} (Compound) causes {v} (Side Effect) Abdominal distension
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Benzthiazide
Glycopyrronium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydrochlorothiazide
Glycopyrronium {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Glycopyrronium (Compound) resembles Hexylcaine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Glycopyrronium (Compound) resembles Oxybutynin (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Glycopyrronium (Compound) binds CHRM3 (Gene)
Glycopyrronium (Compound) downregulates TIMM9 (Gene)
Glycopyrronium (Compound) causes Abdominal distension (Side Effect)
Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Benzthiazide
Glycopyrronium may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide
Glycopyrronium may lead to a major life threatening interaction when taken with Potassium chloride