DDInter576 DDInter431
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has also been investigated in other inflammatory and fibrotic conditions.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Colchicine
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is upregulated by {v} (Compound) Colchicine
Disulfiram {u} (Compound) downregulates {v} (Gene) KIF20A
KIF20A {u} (Gene) is upregulated by {v} (Compound) Colchicine
Disulfiram {u} (Compound) downregulates {v} (Gene) B4GAT1
B4GAT1 {u} (Gene) is downregulated by {v} (Compound) Colchicine
Disulfiram {u} (Compound) upregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Colchicine
Disulfiram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Colchicine
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) interacts with {v} (Gene) MAFG
MAFG {u} (Gene) is upregulated by {v} (Compound) Colchicine
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tofisopam
Tofisopam {u} (Compound) resembles {v} (Compound) Colchicine
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is regulated by {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is upregulated by {v} (Compound) Colchicine
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Colchicine (Compound)
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is upregulated by Colchicine (Compound)
Disulfiram (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is upregulated by Colchicine (Compound)
Disulfiram (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is downregulated by Colchicine (Compound)
Disulfiram (Compound) upregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Colchicine (Compound)
Disulfiram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Colchicine (Compound)
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) interacts with MAFG (Gene) and MAFG (Gene) is upregulated by Colchicine (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tofisopam (Compound) and Tofisopam (Compound) resembles Colchicine (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Colchicine
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is regulated by RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Colchicine (Compound)