DDInter544 DDInter1055
A dideoxynucleoside compound in which the 3&#39;-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Didanosine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Didanosine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Didanosine {u} (Compound) causes {v} (Side Effect) Sensory loss
Sensory loss {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Didanosine {u} (Compound) resembles {v} (Compound) Entecavir
Entecavir {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Didanosine {u} (Compound) resembles {v} (Compound) Zalcitabine
Zalcitabine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Didanosine {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) upregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Didanosine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) regulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Didanosine {u} (Compound) resembles {v} (Compound) Zalcitabine
Zalcitabine {u} (Compound) downregulates {v} (Gene) SNX7
SNX7 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Levofloxacin (Compound)
Didanosine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Levofloxacin (Compound)
Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Didanosine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Didanosine (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Didanosine (Compound) resembles Entecavir (Compound) and Entecavir (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Levofloxacin (Compound)
Didanosine (Compound) resembles Zalcitabine (Compound) and Zalcitabine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Levofloxacin (Compound)
Didanosine (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) upregulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)
Didanosine (Compound) binds PNP (Gene) and PNP (Gene) regulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Levofloxacin (Compound)
Didanosine (Compound) resembles Zalcitabine (Compound) and Zalcitabine (Compound) downregulates SNX7 (Gene) and SNX7 (Gene) is downregulated by Levofloxacin (Compound)