DDInter721 DDInter537
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin]. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).
Fenoprofen {u} (Compound) resembles {v} (Compound) Nepafenac
Nepafenac {u} (Compound) resembles {v} (Compound) Diclofenac
Fenoprofen {u} (Compound) resembles {v} (Compound) Mefenamic acid
Mefenamic acid {u} (Compound) resembles {v} (Compound) Diclofenac
Fenoprofen {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Diclofenac
Fenoprofen {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Diclofenac
Fenoprofen {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Diclofenac
Fenoprofen {u} (Compound) causes {v} (Side Effect) Diplopia
Diplopia {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Fenoprofen {u} (Compound) resembles {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diclofenac
Fenoprofen {u} (Compound) resembles {v} (Compound) Ketoprofen
Ketoprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Fenoprofen {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may lead to a major life threatening interaction when taken with {v} Diclofenac
Fenoprofen {u} (Compound) resembles {v} (Compound) Nepafenac
Nepafenac {u} (Compound) resembles {v} (Compound) Mefenamic acid
Mefenamic acid {u} (Compound) resembles {v} (Compound) Diclofenac
Fenoprofen (Compound) resembles Nepafenac (Compound) and Nepafenac (Compound) resembles Diclofenac (Compound)
Fenoprofen (Compound) resembles Mefenamic acid (Compound) and Mefenamic acid (Compound) resembles Diclofenac (Compound)
Fenoprofen (Compound) binds ALB (Gene) and ALB (Gene) is bound by Diclofenac (Compound)
Fenoprofen (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Diclofenac (Compound)
Fenoprofen (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Diclofenac (Compound)
Fenoprofen (Compound) causes Diplopia (Side Effect) and Diplopia (Side Effect) is caused by Diclofenac (Compound)
Fenoprofen (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Diclofenac
Fenoprofen (Compound) resembles Ketoprofen (Compound) and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac
Fenoprofen (Compound) resembles Warfarin (Compound) and Warfarin may lead to a major life threatening interaction when taken with Diclofenac
Fenoprofen (Compound) resembles Nepafenac (Compound) and Nepafenac (Compound) resembles Mefenamic acid (Compound) and Mefenamic acid (Compound) resembles Diclofenac (Compound)