DDInter1861 DDInter535
A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) binds {v} (Gene) ATP1A1
ATP1A1 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Hydroflumethiazide
Hydroflumethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) regulates {v} (Gene) RBM6
RBM6 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Trichlormethiazide {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Trichlormethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Trichlormethiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Trichlormethiazide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Diazoxide (Compound)
Trichlormethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Trichlormethiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Trichlormethiazide (Compound) binds ATP1A1 (Gene) and ATP1A1 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Trichlormethiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Trichlormethiazide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) regulates RBM6 (Gene) and RBM6 (Gene) is upregulated by Diazoxide (Compound)
Trichlormethiazide (Compound) binds CA2 (Gene) and CA2 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Trichlormethiazide (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is upregulated by Diazoxide (Compound)