DDInter1256 DDInter856
A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Nafcillin {u} (Compound) resembles {v} (Compound) Flucloxacillin
Nafcillin {u} (Compound) resembles {v} (Compound) Mezlocillin
Nafcillin {u} (Compound) binds {v} (Gene) SLC22A6
Nafcillin {u} (Compound) upregulates {v} (Gene) SATB1
Nafcillin {u} (Compound) is included by {v} (Pharmacologic Class) Penicillins
Nafcillin {u} (Compound) downregulates {v} (Gene) COPS7A
Nafcillin {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Nafcillin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Nafcillin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Nafcillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ixabepilone
Nafcillin (Compound) resembles Flucloxacillin (Compound)
Nafcillin (Compound) resembles Mezlocillin (Compound)
Nafcillin (Compound) binds SLC22A6 (Gene)
Nafcillin (Compound) upregulates SATB1 (Gene)
Nafcillin (Compound) is included by Penicillins (Pharmacologic Class)
Nafcillin (Compound) downregulates COPS7A (Gene)
Nafcillin (Compound) causes Gastrointestinal disorder (Side Effect)
Nafcillin may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Nafcillin may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone