DDInter1042 DDInter1115
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the specifications of oral administration of a maximum concentration of 237 mg. It is also considered as an active ingredient in over-the-counter products.
Magnesium citrate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Magnesium citrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Magnesium citrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Magnesium citrate {u} may lead to a major life threatening interaction when taken with {v} Dolutegravir
Magnesium citrate {u} may lead to a major life threatening interaction when taken with {v} Bictegravir
Magnesium citrate may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Magnesium citrate may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Magnesium citrate may lead to a major life threatening interaction when taken with Dolutegravir
Magnesium citrate may lead to a major life threatening interaction when taken with Bictegravir