DDInter1570 DDInter1768
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Ranolazine {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Terbinafine
Ranolazine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Terbinafine
Ranolazine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is downregulated by {v} (Compound) Terbinafine
Ranolazine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Ranolazine {u} (Compound) resembles {v} (Compound) Carvedilol
Carvedilol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Ranolazine {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Naphazoline
Naphazoline {u} (Compound) resembles {v} (Compound) Terbinafine
Ranolazine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Terbinafine
Ranolazine {u} (Compound) upregulates {v} (Gene) DENND2D
DENND2D {u} (Gene) is regulated by {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Terbinafine
Ranolazine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Naphazoline
Naphazoline {u} (Compound) resembles {v} (Compound) Terbinafine
Ranolazine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Terbinafine
Ranolazine (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Terbinafine (Compound)
Ranolazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Ranolazine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is downregulated by Terbinafine (Compound)
Ranolazine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Terbinafine (Compound)
Ranolazine (Compound) resembles Carvedilol (Compound) and Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine
Ranolazine (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Naphazoline (Compound) and Naphazoline (Compound) resembles Terbinafine (Compound)
Ranolazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Terbinafine (Compound)
Ranolazine (Compound) upregulates DENND2D (Gene) and DENND2D (Gene) is regulated by GPC1 (Gene) and GPC1 (Gene) is upregulated by Terbinafine (Compound)
Ranolazine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Naphazoline (Compound) and Naphazoline (Compound) resembles Terbinafine (Compound)
Ranolazine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Propranolol (Compound) and Propranolol (Compound) resembles Terbinafine (Compound)