DDInter690 DDInter1919
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. Food and Drug Administration warned that Varenicline, in the form of Pfizer Inc's quit-smoking drug, Chantix, has been associated with seizures and that some patients who drink while taking the drug may become aggressive or black out. Pfizer is conducting an additional safety study of the drug, results of which are expected in late 2015. The FDA said it is keeping the black box in place at least until the results of the trial are announced.
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) interacts with {v} (Gene) UBC
UBC {u} (Gene) is downregulated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) covaries with {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) AMFR
AMFR {u} (Gene) is upregulated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) GK
GK {u} (Gene) is upregulated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vandetanib
Vandetanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Varenicline
Ethanol {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) regulates {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is upregulated by {v} (Disease) nicotine dependence
nicotine dependence {u} (Disease) is treated by {v} (Compound) Varenicline
Ethanol {u} (Compound) binds {v} (Gene) GRIN3A
GRIN3A {u} (Gene) interacts with {v} (Gene) UBC
UBC {u} (Gene) is downregulated by {v} (Compound) Varenicline
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) interacts with UBC (Gene) and UBC (Gene) is downregulated by Varenicline (Compound)
Ethanol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Varenicline
Ethanol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) covaries with PAK1 (Gene) and PAK1 (Gene) is upregulated by Varenicline (Compound)
Ethanol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with AMFR (Gene) and AMFR (Gene) is upregulated by Varenicline (Compound)
Ethanol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with GK (Gene) and GK (Gene) is upregulated by Varenicline (Compound)
Ethanol (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Varenicline (Compound)
Ethanol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound) and Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Varenicline
Ethanol (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) regulates PNP (Gene) and PNP (Gene) is downregulated by Varenicline (Compound)
Ethanol (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by nicotine dependence (Disease) and nicotine dependence (Disease) is treated by Varenicline (Compound)
Ethanol (Compound) binds GRIN3A (Gene) and GRIN3A (Gene) interacts with UBC (Gene) and UBC (Gene) is downregulated by Varenicline (Compound)