DDInter658 DDInter856
Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Eprosartan {u} (Compound) resembles {v} (Compound) Losartan
Eprosartan {u} (Compound) treats {v} (Disease) hypertension
Eprosartan {u} (Compound) binds {v} (Gene) CYP2C9
Eprosartan {u} (Compound) upregulates {v} (Gene) GPER1
Eprosartan {u} (Compound) is included by {v} (Pharmacologic Class) Angiotensin 2 Receptor Antagonists
Eprosartan {u} (Compound) downregulates {v} (Gene) KRT18
Eprosartan {u} (Compound) causes {v} (Side Effect) Arthralgia
Eprosartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Eprosartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glargine
Eprosartan {u} may lead to a major life threatening interaction when taken with {v} Potassium gluconate
Eprosartan (Compound) resembles Losartan (Compound)
Eprosartan (Compound) treats hypertension (Disease)
Eprosartan (Compound) binds CYP2C9 (Gene)
Eprosartan (Compound) upregulates GPER1 (Gene)
Eprosartan (Compound) is included by Angiotensin 2 Receptor Antagonists (Pharmacologic Class)
Eprosartan (Compound) downregulates KRT18 (Gene)
Eprosartan (Compound) causes Arthralgia (Side Effect)
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine
Eprosartan may lead to a major life threatening interaction when taken with Potassium gluconate