DDInter1793 DDInter1376
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Thiethylperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium carbonate
Thiethylperazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pregabalin
Thiethylperazine {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Thiethylperazine {u} may lead to a major life threatening interaction when taken with {v} Tramadol
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Thiethylperazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pregabalin
Thiethylperazine may lead to a major life threatening interaction when taken with Iohexol
Thiethylperazine may lead to a major life threatening interaction when taken with Tramadol