DDInter1233 DDInter656
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
Mitotane {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Eplerenone
Mitotane {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eplerenone
Mitotane {u} (Compound) causes {v} (Side Effect) Hypothyroidism
Hypothyroidism {u} (Side Effect) is caused by {v} (Compound) Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Eplerenone
Mitotane {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Eplerenone
Mitotane {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Nabilone
Nabilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eplerenone
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Eplerenone
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) resembles {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eplerenone
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) downregulates {v} (Gene) PLEKHM1
PLEKHM1 {u} (Gene) is downregulated by {v} (Compound) Eplerenone
Mitotane {u} (Compound) causes {v} (Side Effect) Hypothyroidism
Hypothyroidism {u} (Side Effect) is caused by {v} (Compound) Potassium Iodide
Potassium Iodide {u} may lead to a major life threatening interaction when taken with {v} Eplerenone
Mitotane {u} (Compound) causes {v} (Side Effect) Haematuria
Haematuria {u} (Side Effect) is caused by {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Eplerenone
Mitotane (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Eplerenone (Compound)
Mitotane (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Mitotane (Compound) causes Hypothyroidism (Side Effect) and Hypothyroidism (Side Effect) is caused by Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate (Compound) resembles Eplerenone (Compound)
Mitotane (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Eplerenone (Compound)
Mitotane (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Nabilone (Compound) and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Eplerenone (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) resembles Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) downregulates PLEKHM1 (Gene) and PLEKHM1 (Gene) is downregulated by Eplerenone (Compound)
Mitotane (Compound) causes Hypothyroidism (Side Effect) and Hypothyroidism (Side Effect) is caused by Potassium Iodide (Compound) and Potassium Iodide may lead to a major life threatening interaction when taken with Eplerenone
Mitotane (Compound) causes Haematuria (Side Effect) and Haematuria (Side Effect) is caused by Enzalutamide (Compound) and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Eplerenone