DDInter1037 DDInter808
Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the substitution of leucine for isoleucine at position 1 (N-terminal end). Lepirudin is used as an anticoagulant in patients with heparin-induced thrombocytopenia (HIT), an immune reaction associated with a high risk of thromboembolic complications.[A3, L41539] HIT is caused by the expression of immunoglobulin G (IgG) antibodies that bind to the complex formed by heparin and
Garlic allergenic extract is used in allergenic testing.
Lepirudin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Lepirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ginger
Lepirudin {u} may lead to a major life threatening interaction when taken with {v} Anisindione
Lepirudin may cause a minor interaction that can limit clinical effects when taken with Turmeric
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Lepirudin may lead to a major life threatening interaction when taken with Anisindione