DDInter458 DDInter1010
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urine output increased
Urine output increased {u} (Side Effect) is caused by {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Mebendazole
Mebendazole {u} (Compound) resembles {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Mebendazole
Mebendazole {u} (Compound) resembles {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) regulates {v} (Gene) FAIM
FAIM {u} (Gene) is upregulated by {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urine output increased
Urine output increased {u} (Side Effect) is caused by {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) resembles {v} (Compound) Ketorolac
Cyclosporine {u} (Compound) causes {v} (Side Effect) Blood creatinine increased
Blood creatinine increased {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ketorolac
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Ketorolac (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Ketorolac (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is downregulated by Ketorolac (Compound)
Cyclosporine (Compound) causes Urine output increased (Side Effect) and Urine output increased (Side Effect) is caused by Ketorolac (Compound)
Cyclosporine (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ketorolac (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Mebendazole (Compound) and Mebendazole (Compound) resembles Ketorolac (Compound)
Cyclosporine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Mebendazole (Compound) and Mebendazole (Compound) resembles Ketorolac (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) regulates FAIM (Gene) and FAIM (Gene) is upregulated by Ketorolac (Compound)
Cyclosporine (Compound) causes Urine output increased (Side Effect) and Urine output increased (Side Effect) is caused by Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) resembles Ketorolac (Compound)
Cyclosporine (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ketorolac