DDInter463 DDInter178
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Dacarbazine {u} (Compound) treats {v} (Disease) skin cancer
Dacarbazine {u} (Compound) binds {v} (Gene) POLA2
Dacarbazine {u} (Compound) upregulates {v} (Gene) CADM1
Dacarbazine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Dacarbazine {u} (Compound) downregulates {v} (Gene) HMGCS1
Dacarbazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lomefloxacin
Dacarbazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cinoxacin
Dacarbazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Floxuridine
Dacarbazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brentuximab vedotin
Dacarbazine {u} may lead to a major life threatening interaction when taken with {v} Aldesleukin
Dacarbazine (Compound) treats skin cancer (Disease)
Dacarbazine (Compound) binds POLA2 (Gene)
Dacarbazine (Compound) upregulates CADM1 (Gene)
Dacarbazine (Compound) is included by Alkylating Activity (Pharmacologic Class)
Dacarbazine (Compound) downregulates HMGCS1 (Gene)
Dacarbazine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin
Dacarbazine may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Dacarbazine may lead to a major life threatening interaction when taken with Aldesleukin