DDInter458 DDInter889
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CNPY3
CNPY3 {u} (Gene) is upregulated by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is downregulated by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) upregulates {v} (Gene) CNPY3
CNPY3 {u} (Gene) regulates {v} (Gene) MIF
MIF {u} (Gene) is downregulated by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is downregulated by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Hydroflumethiazide
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Hydroflumethiazide
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Hydroflumethiazide (Compound)
Cyclosporine (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Hydroflumethiazide (Compound)
Cyclosporine (Compound) downregulates PSMD2 (Gene) and PSMD2 (Gene) is downregulated by Hydroflumethiazide (Compound)
Cyclosporine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Hydroflumethiazide (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Hydroflumethiazide (Compound)
Cyclosporine (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) regulates MIF (Gene) and MIF (Gene) is downregulated by Hydroflumethiazide (Compound)
Cyclosporine (Compound) downregulates PSMD2 (Gene) and PSMD2 (Gene) is downregulated by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Hydroflumethiazide (Compound)
Cyclosporine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)