DDInter1675 DDInter119
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Simvastatin {u} (Compound) treats {v} (Disease) atherosclerosis
Simvastatin {u} (Compound) binds {v} (Gene) ABCC2
Simvastatin {u} (Compound) upregulates {v} (Gene) ANKRD10
Simvastatin {u} (Compound) downregulates {v} (Gene) PNP
Simvastatin {u} (Compound) causes {v} (Side Effect) Cataract
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dapagliflozin
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Liothyronine
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duvelisib
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Interferon alfacon-1
Simvastatin {u} may lead to a major life threatening interaction when taken with {v} Colchicine
Simvastatin (Compound) treats atherosclerosis (Disease)
Simvastatin (Compound) binds ABCC2 (Gene)
Simvastatin (Compound) upregulates ANKRD10 (Gene)
Simvastatin (Compound) downregulates PNP (Gene)
Simvastatin (Compound) causes Cataract (Side Effect)
Simvastatin may cause a minor interaction that can limit clinical effects when taken with Dapagliflozin
Simvastatin may cause a minor interaction that can limit clinical effects when taken with Liothyronine
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1
Simvastatin may lead to a major life threatening interaction when taken with Colchicine