DDInter128 DDInter1016
Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Astemizole {u} (Compound) resembles {v} (Compound) Fentanyl
Astemizole {u} (Compound) resembles {v} (Compound) Flunarizine
Astemizole {u} may lead to a major life threatening interaction when taken with {v} Pimozide
Astemizole {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Astemizole {u} (Compound) upregulates {v} (Gene) LIPA
Astemizole {u} (Compound) downregulates {v} (Gene) RPS4Y1
Astemizole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Astemizole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Astemizole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Astemizole {u} may lead to a major life threatening interaction when taken with {v} Methadone
Astemizole (Compound) resembles Fentanyl (Compound)
Astemizole (Compound) resembles Flunarizine (Compound)
Astemizole may lead to a major life threatening interaction when taken with Pimozide
Astemizole (Compound) binds CYP3A7-CYP3A51P (Gene)
Astemizole (Compound) upregulates LIPA (Gene)
Astemizole (Compound) downregulates RPS4Y1 (Gene)
Astemizole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib
Astemizole may lead to a major life threatening interaction when taken with Methadone