DDInter1470 DDInter927
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Inotuzumab ozogamicin is an antibody-drug conjugate using linker and cytotoxic drug technology similar to that developed for the ground-breaking treatment Mylotarg (), which was approved by the US FDA in 2000 for the treatment of acute myeloid leukaemia. Inotuzumab ozogamicin consists of a recombinant humanised IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide, which is a potent DNA-binding cytotoxic agent . Developed by Pfizer and UCB, inotuzumab ozogamicin was granted approval by EU in June 2017 followed by FDA on August 17th, 2017 for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). ALL is a rapidly progressing cancer of the bone marrow that is associated with high mortality rates and low therapeutic response from standard chemotherapies in relasping conditions. In a randomized trial, inotuzumab ozogamicin displayed higher percentages of patients undergoing longer periods of complete remission with no evidence of disease in comparison to patients receiving alternative chemotherapy .
Pimozide {u} (Compound) resembles {v} (Compound) Fexofenadine
Pimozide {u} (Compound) resembles {v} (Compound) Ezetimibe
Pimozide {u} may lead to a major life threatening interaction when taken with {v} Astemizole
Pimozide {u} (Compound) binds {v} (Gene) CALM3
Pimozide {u} (Compound) upregulates {v} (Gene) GNPDA1
Pimozide {u} (Compound) palliates {v} (Disease) Gilles de la Tourette syndrome
Pimozide {u} (Compound) downregulates {v} (Gene) TMEM109
Pimozide {u} (Compound) causes {v} (Side Effect) Hypertension
Pimozide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Pimozide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Pimozide (Compound) resembles Fexofenadine (Compound)
Pimozide (Compound) resembles Ezetimibe (Compound)
Pimozide may lead to a major life threatening interaction when taken with Astemizole
Pimozide (Compound) binds CALM3 (Gene)
Pimozide (Compound) upregulates GNPDA1 (Gene)
Pimozide (Compound) palliates Gilles de la Tourette syndrome (Disease)
Pimozide (Compound) downregulates TMEM109 (Gene)
Pimozide (Compound) causes Hypertension (Side Effect)
Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine