DDInter406 DDInter1016
Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids. Although it carries _in vitro_ activity against other mycobacterium, such as _Mycobacterium tuberculosis_, it is generally considered an ineffective treatment in comparison to classic tuberculosis treatments such as [rifampicin] and [isoniazid].
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Clofazimine {u} (Compound) binds {v} (Gene) ABCB1
Clofazimine {u} (Compound) upregulates {v} (Gene) HERPUD1
Clofazimine {u} (Compound) downregulates {v} (Gene) TUBB6
Clofazimine {u} (Compound) causes {v} (Side Effect) Dermatitis
Clofazimine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Clofazimine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pazopanib
Clofazimine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Clofazimine {u} may lead to a major life threatening interaction when taken with {v} Toremifene
Clofazimine {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Clofazimine (Compound) binds ABCB1 (Gene)
Clofazimine (Compound) upregulates HERPUD1 (Gene)
Clofazimine (Compound) downregulates TUBB6 (Gene)
Clofazimine (Compound) causes Dermatitis (Side Effect)
Clofazimine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin
Clofazimine may lead to a major life threatening interaction when taken with Toremifene
Clofazimine may lead to a major life threatening interaction when taken with Crizotinib