DDInter285 DDInter178
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Capecitabine {u} (Compound) treats {v} (Disease) colon cancer
Capecitabine {u} (Compound) binds {v} (Gene) TYMS
Capecitabine {u} (Compound) upregulates {v} (Gene) MCOLN1
Capecitabine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Capecitabine {u} (Compound) causes {v} (Side Effect) Tonsillitis
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gemifloxacin
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Capecitabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Strontium chloride Sr-89
Capecitabine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Capecitabine (Compound) treats colon cancer (Disease)
Capecitabine (Compound) binds TYMS (Gene)
Capecitabine (Compound) upregulates MCOLN1 (Gene)
Capecitabine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Capecitabine (Compound) causes Tonsillitis (Side Effect)
Capecitabine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin
Capecitabine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Capecitabine may lead to a major life threatening interaction when taken with Cladribine