DDInter255 DDInter809
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Busulfan {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) regulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) BID
BID {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) upregulates {v} (Gene) HLA-DRA
HLA-DRA {u} (Gene) is regulated by {v} (Gene) DYRK3
DYRK3 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) CTSL
CTSL {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Gatifloxacin
Busulfan {u} (Compound) downregulates {v} (Gene) BNIP3L
BNIP3L {u} (Gene) is regulated by {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Busulfan (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Gatifloxacin (Compound)
Busulfan (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is upregulated by Gatifloxacin (Compound)
Busulfan (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Gatifloxacin (Compound)
Busulfan (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Gatifloxacin (Compound)
Busulfan (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) regulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Gatifloxacin (Compound)
Busulfan (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by BID (Gene) and BID (Gene) is upregulated by Gatifloxacin (Compound)
Busulfan (Compound) upregulates HLA-DRA (Gene) and HLA-DRA (Gene) is regulated by DYRK3 (Gene) and DYRK3 (Gene) is upregulated by Gatifloxacin (Compound)
Busulfan (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Gatifloxacin (Compound)
Busulfan (Compound) downregulates CTSL (Gene) and CTSL (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Gatifloxacin (Compound)
Busulfan (Compound) downregulates BNIP3L (Gene) and BNIP3L (Gene) is regulated by RBM34 (Gene) and RBM34 (Gene) is downregulated by Gatifloxacin (Compound)