DDInter255 DDInter745
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Fludarabine
Busulfan {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Fludarabine
Busulfan {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Fludarabine
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Fludarabine
Busulfan {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Fludarabine
Busulfan {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Regadenoson
Regadenoson {u} (Compound) resembles {v} (Compound) Fludarabine
Busulfan {u} (Compound) causes {v} (Side Effect) Fibrosis
Fibrosis {u} (Side Effect) is caused by {v} (Compound) Hydroxyurea
Hydroxyurea {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Busulfan {u} (Compound) causes {v} (Side Effect) Oesophagitis
Oesophagitis {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fludarabine
Busulfan {u} (Compound) causes {v} (Side Effect) Aplasia
Aplasia {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludarabine
Busulfan {u} (Compound) upregulates {v} (Gene) ABL1
ABL1 {u} (Gene) is bound by {v} (Compound) Adenosine triphosphate
Adenosine triphosphate {u} (Compound) resembles {v} (Compound) Fludarabine
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Fludarabine (Compound)
Busulfan (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Fludarabine (Compound)
Busulfan (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Fludarabine (Compound)
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nelarabine (Compound) and Nelarabine (Compound) resembles Fludarabine (Compound)
Busulfan (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Nelarabine (Compound) and Nelarabine (Compound) resembles Fludarabine (Compound)
Busulfan (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Regadenoson (Compound) and Regadenoson (Compound) resembles Fludarabine (Compound)
Busulfan (Compound) causes Fibrosis (Side Effect) and Fibrosis (Side Effect) is caused by Hydroxyurea (Compound) and Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Busulfan (Compound) causes Oesophagitis (Side Effect) and Oesophagitis (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine
Busulfan (Compound) causes Aplasia (Side Effect) and Aplasia (Side Effect) is caused by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine
Busulfan (Compound) upregulates ABL1 (Gene) and ABL1 (Gene) is bound by Adenosine triphosphate (Compound) and Adenosine triphosphate (Compound) resembles Fludarabine (Compound)