DDInter1852 DDInter396
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcut
Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isradipine
Isradipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Clevidipine
Treprostinil {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Clevidipine
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isradipine
Isradipine {u} (Compound) resembles {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nifedipine
Nifedipine {u} (Compound) resembles {v} (Compound) Clevidipine
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Clevidipine (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Clevidipine (Compound)
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Clevidipine (Compound)
Treprostinil (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Clevidipine (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nicardipine (Compound) and Nicardipine (Compound) resembles Clevidipine (Compound)
Treprostinil (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Nicardipine (Compound) and Nicardipine (Compound) resembles Clevidipine (Compound)
Treprostinil (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine (Compound) and Nifedipine (Compound) resembles Clevidipine (Compound)