DDInter363 DDInter1376
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Chlorpromazine {u} (Compound) resembles {v} (Compound) Prochlorperazine
Chlorpromazine {u} (Compound) resembles {v} (Compound) Ethopropazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Chlorpromazine {u} (Compound) binds {v} (Gene) HTR2C
Chlorpromazine {u} (Compound) upregulates {v} (Gene) AARS
Chlorpromazine {u} (Compound) palliates {v} (Disease) bipolar disorder
Chlorpromazine {u} (Compound) is included by {v} (Pharmacologic Class) Phenothiazines
Chlorpromazine {u} (Compound) downregulates {v} (Gene) EED
Chlorpromazine {u} (Compound) causes {v} (Side Effect) Convulsion
Chlorpromazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Chlorpromazine (Compound) resembles Prochlorperazine (Compound)
Chlorpromazine (Compound) resembles Ethopropazine (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Chlorpromazine (Compound) binds HTR2C (Gene)
Chlorpromazine (Compound) upregulates AARS (Gene)
Chlorpromazine (Compound) palliates bipolar disorder (Disease)
Chlorpromazine (Compound) is included by Phenothiazines (Pharmacologic Class)
Chlorpromazine (Compound) downregulates EED (Gene)
Chlorpromazine (Compound) causes Convulsion (Side Effect)
Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide