DDInter343 DDInter1662
Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allergic rhinitis_. The prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals. Furthermore, some antihistamine agents that are used to treat this condition cause undesirable, sedating effects. Cetirizine is one of the first second-generation H1 antihistamines (SGAHs) formulated to selectively inhibit the H1 receptor
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Cetirizine {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Cetirizine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Cetirizine {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) regulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Cetirizine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Cetirizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Ifenprodil {u} (Compound) binds {v} (Gene) SIGMAR1
SIGMAR1 {u} (Gene) is bound by {v} (Compound) Sertraline
Cetirizine {u} (Compound) resembles {v} (Compound) Bepotastine
Bepotastine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Sertraline
Cetirizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Ifenprodil {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Sertraline
Cetirizine {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is regulated by {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Sertraline
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Cetirizine (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Sertraline (Compound)
Cetirizine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Cetirizine (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) regulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sertraline (Compound)
Cetirizine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Cetirizine (Compound) resembles Ifenprodil (Compound) and Ifenprodil (Compound) binds SIGMAR1 (Gene) and SIGMAR1 (Gene) is bound by Sertraline (Compound)
Cetirizine (Compound) resembles Bepotastine (Compound) and Bepotastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Sertraline (Compound)
Cetirizine (Compound) resembles Ifenprodil (Compound) and Ifenprodil (Compound) binds EBP (Gene) and EBP (Gene) is upregulated by Sertraline (Compound)
Cetirizine (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is regulated by HMGCR (Gene) and HMGCR (Gene) is upregulated by Sertraline (Compound)