DDInter336 DDInter188
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Benzthiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA9
CA9 {u} (Gene) is bound by {v} (Compound) Metolazone
Metolazone {u} (Compound) resembles {v} (Compound) Benzthiazide
Celecoxib {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Trichlormethiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Metolazone
Metolazone {u} (Compound) resembles {v} (Compound) Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} (Compound) resembles {v} (Compound) Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Hyoscyamine
Hyoscyamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Repaglinide
Repaglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Skin exfoliation
Skin exfoliation {u} (Side Effect) is caused by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Benzthiazide
Celecoxib {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Dolasetron {u} may lead to a major life threatening interaction when taken with {v} Benzthiazide
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Benzthiazide (Compound)
Celecoxib (Compound) binds CA9 (Gene) and CA9 (Gene) is bound by Metolazone (Compound) and Metolazone (Compound) resembles Benzthiazide (Compound)
Celecoxib (Compound) binds CA2 (Gene) and CA2 (Gene) is bound by Trichlormethiazide (Compound) and Trichlormethiazide (Compound) resembles Benzthiazide (Compound)
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Metolazone (Compound) and Metolazone (Compound) resembles Benzthiazide (Compound)
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Hydrochlorothiazide (Compound) and Hydrochlorothiazide (Compound) resembles Benzthiazide (Compound)
Celecoxib (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Hyoscyamine (Compound) and Hyoscyamine may cause a minor interaction that can limit clinical effects when taken with Benzthiazide
Celecoxib (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Atropine (Compound) and Atropine may cause a minor interaction that can limit clinical effects when taken with Benzthiazide
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Repaglinide (Compound) and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide
Celecoxib (Compound) causes Skin exfoliation (Side Effect) and Skin exfoliation (Side Effect) is caused by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide
Celecoxib (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Dolasetron (Compound) and Dolasetron may lead to a major life threatening interaction when taken with Benzthiazide