DDInter1619 DDInter1427
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. Other forms of pentoxyverine citrate continue to be marketed.
Ropinirole {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Nalbuphine
Nalbuphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Nalbuphine
Nalbuphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) causes {v} (Side Effect) Delusion
Delusion {u} (Side Effect) is caused by {v} (Compound) Rasagiline
Rasagiline {u} may lead to a major life threatening interaction when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Rasagiline
Rasagiline {u} may lead to a major life threatening interaction when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) palliates {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is palliated by {v} (Compound) Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) palliates {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is palliated by {v} (Compound) Selegiline
Selegiline {u} may lead to a major life threatening interaction when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) upregulates {v} (Gene) GHR
GHR {u} (Gene) is downregulated by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Risperidone
Risperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Ropinirole (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Nalbuphine (Compound) and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ropinirole (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Nalbuphine (Compound) and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ropinirole (Compound) causes Delusion (Side Effect) and Delusion (Side Effect) is caused by Rasagiline (Compound) and Rasagiline may lead to a major life threatening interaction when taken with Pentoxyverine
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rasagiline (Compound) and Rasagiline may lead to a major life threatening interaction when taken with Pentoxyverine
Ropinirole (Compound) upregulates NNT (Gene) and NNT (Gene) is upregulated by Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ropinirole (Compound) palliates Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is palliated by Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ropinirole (Compound) palliates Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is palliated by Selegiline (Compound) and Selegiline may lead to a major life threatening interaction when taken with Pentoxyverine
Ropinirole (Compound) upregulates GHR (Gene) and GHR (Gene) is downregulated by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Risperidone (Compound) and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine