DDInter343 DDInter1960
Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allergic rhinitis_. The prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals. Furthermore, some antihistamine agents that are used to treat this condition cause undesirable, sedating effects. Cetirizine is one of the first second-generation H1 antihistamines (SGAHs) formulated to selectively inhibit the H1 receptor
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Cetirizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cetirizine {u} (Compound) resembles {v} (Compound) Prochlorperazine
Cetirizine {u} (Compound) treats {v} (Disease) allergic rhinitis
Cetirizine {u} (Compound) binds {v} (Gene) HRH1
Cetirizine {u} (Compound) upregulates {v} (Gene) UBQLN2
Cetirizine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Cetirizine {u} (Compound) downregulates {v} (Gene) FIS1
Cetirizine {u} (Compound) causes {v} (Side Effect) Paralysis
Cetirizine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Cetirizine (Compound) resembles Ifenprodil (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Cetirizine (Compound) resembles Prochlorperazine (Compound)
Cetirizine (Compound) treats allergic rhinitis (Disease)
Cetirizine (Compound) binds HRH1 (Gene)
Cetirizine (Compound) upregulates UBQLN2 (Gene)
Cetirizine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Cetirizine (Compound) downregulates FIS1 (Gene)
Cetirizine (Compound) causes Paralysis (Side Effect)
Cetirizine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase