DDInter162 DDInter1244
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Baclofen {u} (Compound) causes {v} (Side Effect) Hepatobiliary disease
Hepatobiliary disease {u} (Side Effect) is caused by {v} (Compound) Morphine
Baclofen {u} (Compound) causes {v} (Side Effect) Hepatobiliary disease
Hepatobiliary disease {u} (Side Effect) is caused by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Morphine
Baclofen {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Baclofen {u} (Compound) causes {v} (Side Effect) Slurred speech
Slurred speech {u} (Side Effect) is caused by {v} (Compound) Midazolam
Midazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Baclofen {u} (Compound) causes {v} (Side Effect) Abnormal ejaculation
Abnormal ejaculation {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Baclofen {u} (Compound) causes {v} (Side Effect) Pallor
Pallor {u} (Side Effect) is caused by {v} (Compound) Ephedrine
Ephedrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Morphine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Baclofen {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Morphine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Morphine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Baclofen (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Morphine (Compound)
Baclofen (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by Galantamine (Compound) and Galantamine (Compound) resembles Morphine (Compound)
Baclofen (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone may lead to a major life threatening interaction when taken with Morphine
Baclofen (Compound) causes Slurred speech (Side Effect) and Slurred speech (Side Effect) is caused by Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Baclofen (Compound) causes Abnormal ejaculation (Side Effect) and Abnormal ejaculation (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Baclofen (Compound) causes Pallor (Side Effect) and Pallor (Side Effect) is caused by Ephedrine (Compound) and Ephedrine may cause a minor interaction that can limit clinical effects when taken with Morphine
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Baclofen (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Hydrocodone (Compound) and Hydrocodone (Compound) resembles Morphine (Compound)
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Morphine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may lead to a major life threatening interaction when taken with Morphine