DDInter1619 DDInter380
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Cimetidine
Ropinirole {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Albendazole
Albendazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) covaries with {v} (Gene) FMO3
FMO3 {u} (Gene) is bound by {v} (Compound) Cimetidine
Ropinirole {u} (Compound) causes {v} (Side Effect) Flatulence
Flatulence {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Ketoprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ropinirole {u} (Compound) causes {v} (Side Effect) Arthralgia
Arthralgia {u} (Side Effect) is caused by {v} (Compound) Ketorolac
Ketorolac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ropinirole {u} (Compound) binds {v} (Gene) HTR1B
HTR1B {u} (Gene) is associated with {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Cimetidine
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nabumetone
Nabumetone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ropinirole {u} (Compound) binds {v} (Gene) HTR1B
HTR1B {u} (Gene) is bound by {v} (Compound) Zolmitriptan
Zolmitriptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Ropinirole {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cimetidine
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cimetidine (Compound)
Ropinirole (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Albendazole (Compound) and Albendazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) covaries with FMO3 (Gene) and FMO3 (Gene) is bound by Cimetidine (Compound)
Ropinirole (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Ketoprofen (Compound) and Ketoprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Ropinirole (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Ketorolac (Compound) and Ketorolac may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Ropinirole (Compound) binds HTR1B (Gene) and HTR1B (Gene) is associated with obesity (Disease) and obesity (Disease) is treated by Cimetidine (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nabumetone (Compound) and Nabumetone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Ropinirole (Compound) binds HTR1B (Gene) and HTR1B (Gene) is bound by Zolmitriptan (Compound) and Zolmitriptan may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Ropinirole (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)