DDInter1642 DDInter148
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis. The other one is through the inhibition of DNA methyltransferase, impairing DNA methylation. Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA, azacytidine has been used mainly used in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), two types of cancer characterized by the presence of aberrant DNA methylation.[A1407,A1410,A1411,A1416,A1417] In May 2004, the FDA approved the use of azacitidine administered subcutaneously for the treatment of MDS of all French-American-British (FAB) subtypes. In January 2007, the FDA approved the intravenous administration of azacitidine. The use of oral azacitidine for the treatment of AML in patients in complete remission was approved by the FDA in September 2020.
Azacitidine {u} (Compound) resembles {v} (Compound) Adenosine
Azacitidine {u} (Compound) resembles {v} (Compound) S-Adenosylmethionine
Azacitidine {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Azacitidine {u} (Compound) binds {v} (Gene) DNMT3A
Azacitidine {u} (Compound) upregulates {v} (Gene) FOXJ3
Azacitidine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Azacitidine {u} (Compound) downregulates {v} (Gene) ANXA2
Azacitidine {u} (Compound) causes {v} (Side Effect) Neck pain
Azacitidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Candida albicans
Azacitidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Efalizumab
Azacitidine (Compound) resembles Adenosine (Compound)
Azacitidine (Compound) resembles S-Adenosylmethionine (Compound)
Azacitidine may lead to a major life threatening interaction when taken with Cladribine
Azacitidine (Compound) binds DNMT3A (Gene)
Azacitidine (Compound) upregulates FOXJ3 (Gene)
Azacitidine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Azacitidine (Compound) downregulates ANXA2 (Gene)
Azacitidine (Compound) causes Neck pain (Side Effect)
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab