DDInter1834 DDInter136
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products.[A251660,L42840] Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters.[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes. Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Atropine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Hyoscyamine
Hyoscyamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Hyoscyamine
Hyoscyamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Hallucination
Hallucination {u} (Side Effect) is caused by {v} (Compound) Cyclopentolate
Cyclopentolate {u} (Compound) resembles {v} (Compound) Atropine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Hypertonia
Hypertonia {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Anhidrosis
Anhidrosis {u} (Side Effect) is caused by {v} (Compound) Propantheline
Propantheline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Heat intolerance
Heat intolerance {u} (Side Effect) is caused by {v} (Compound) Scopolamine
Scopolamine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Topiramate {u} (Compound) causes {v} (Side Effect) Balance disorder
Balance disorder {u} (Side Effect) is caused by {v} (Compound) Acetaminophen
Acetaminophen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atropine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Atropine (Compound)
Topiramate (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Atropine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Hyoscyamine (Compound) and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Topiramate (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Hyoscyamine (Compound) and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Topiramate (Compound) causes Hallucination (Side Effect) and Hallucination (Side Effect) is caused by Cyclopentolate (Compound) and Cyclopentolate (Compound) resembles Atropine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Atropine (Compound)
Topiramate (Compound) causes Hypertonia (Side Effect) and Hypertonia (Side Effect) is caused by Indapamide (Compound) and Indapamide may cause a minor interaction that can limit clinical effects when taken with Atropine
Topiramate (Compound) causes Anhidrosis (Side Effect) and Anhidrosis (Side Effect) is caused by Propantheline (Compound) and Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Topiramate (Compound) causes Heat intolerance (Side Effect) and Heat intolerance (Side Effect) is caused by Scopolamine (Compound) and Scopolamine (Compound) resembles Atropine (Compound) and Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Topiramate (Compound) causes Balance disorder (Side Effect) and Balance disorder (Side Effect) is caused by Acetaminophen (Compound) and Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Atropine