DDInter1055 DDInter125
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Asenapine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Levofloxacin {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Levofloxacin {u} (Compound) upregulates {v} (Gene) FKBP14
FKBP14 {u} (Gene) is upregulated by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Levofloxacin {u} (Compound) downregulates {v} (Gene) ZNF395
ZNF395 {u} (Gene) is downregulated by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Levofloxacin {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Levofloxacin {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Levofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Asenapine
Levofloxacin {u} (Compound) palliates {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is associated with {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Asenapine
Levofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Norfloxacin {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Asenapine
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Asenapine (Compound)
Levofloxacin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)
Levofloxacin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Levofloxacin (Compound) upregulates FKBP14 (Gene) and FKBP14 (Gene) is upregulated by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Levofloxacin (Compound) downregulates ZNF395 (Gene) and ZNF395 (Gene) is downregulated by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Levofloxacin (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)
Levofloxacin (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)
Levofloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Asenapine (Compound)
Levofloxacin (Compound) palliates chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is associated with ADRB2 (Gene) and ADRB2 (Gene) is bound by Asenapine (Compound)
Levofloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Asenapine (Compound)