DDInter458 DDInter582
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. On November 21, 2017, dolutegravir, in combination with rilpivirine, was approved as part of the first complete treatment regimen with only two drugs for the treatment of adults with HIV-1 named Juluca.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Dolutegravir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Griseofulvin
Griseofulvin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dolutegravir
Cyclosporine {u} (Compound) upregulates {v} (Gene) SEC23B
SEC23B {u} (Gene) interacts with {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is bound by {v} (Compound) Dolutegravir
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is regulated by {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is bound by {v} (Compound) Dolutegravir
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) UGT1A1
UGT1A1 {u} (Gene) is bound by {v} (Compound) Dolutegravir
Cyclosporine {u} (Compound) upregulates {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Nilotinib
Nilotinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dolutegravir
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Metformin
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dolutegravir
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dolutegravir
Cyclosporine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dolutegravir
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dolutegravir
Cyclosporine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dolutegravir (Compound)
Cyclosporine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Griseofulvin (Compound) and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Dolutegravir
Cyclosporine (Compound) upregulates SEC23B (Gene) and SEC23B (Gene) interacts with UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Dolutegravir (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is regulated by UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Dolutegravir (Compound)
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Dolutegravir (Compound)
Cyclosporine (Compound) upregulates UGDH (Gene) and UGDH (Gene) is downregulated by Nilotinib (Compound) and Nilotinib may cause a minor interaction that can limit clinical effects when taken with Dolutegravir
Cyclosporine (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Metformin (Compound) and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Dolutegravir
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Dolutegravir
Cyclosporine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Sorafenib (Compound) and Sorafenib may cause a minor interaction that can limit clinical effects when taken with Dolutegravir
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Dasatinib (Compound) and Dasatinib may cause a minor interaction that can limit clinical effects when taken with Dolutegravir