DDInter150 DDInter704
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Azathioprine {u} (Compound) upregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Azathioprine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Everolimus
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Azathioprine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Everolimus
Azathioprine {u} (Compound) upregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Azathioprine {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Azathioprine {u} (Compound) downregulates {v} (Gene) INTS3
INTS3 {u} (Gene) regulates {v} (Gene) TMEM2
TMEM2 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Azathioprine {u} (Compound) upregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) MTOR
MTOR {u} (Gene) is bound by {v} (Compound) Everolimus
Azathioprine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Azathioprine (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Everolimus (Compound)
Azathioprine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Everolimus (Compound)
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Everolimus (Compound)
Azathioprine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Everolimus (Compound)
Azathioprine (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Everolimus (Compound)
Azathioprine (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is downregulated by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Azathioprine (Compound) downregulates INTS3 (Gene) and INTS3 (Gene) regulates TMEM2 (Gene) and TMEM2 (Gene) is upregulated by Everolimus (Compound)
Azathioprine (Compound) upregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by MTOR (Gene) and MTOR (Gene) is bound by Everolimus (Compound)
Azathioprine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)