DDInter1042 DDInter1704
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.[Label,L6373,L6376]
Sotalol {u} (Compound) resembles {v} (Compound) Atenolol
Sotalol {u} (Compound) binds {v} (Gene) ADRB1
Sotalol {u} (Compound) is included by {v} (Pharmacologic Class) Cardiac Rhythm Alteration
Sotalol {u} (Compound) causes {v} (Side Effect) Ache
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin degludec
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Sotalol {u} may lead to a major life threatening interaction when taken with {v} Picosulfuric acid
Sotalol {u} may lead to a major life threatening interaction when taken with {v} Terfenadine
Sotalol (Compound) resembles Atenolol (Compound)
Sotalol (Compound) binds ADRB1 (Gene)
Sotalol (Compound) is included by Cardiac Rhythm Alteration (Pharmacologic Class)
Sotalol (Compound) causes Ache (Side Effect)
Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Sotalol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Sotalol may lead to a major life threatening interaction when taken with Picosulfuric acid
Sotalol may lead to a major life threatening interaction when taken with Terfenadine