DDInter1619 DDInter1878
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tripelennamine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) resembles {v} (Compound) Tripelennamine
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Brompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Tripelennamine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Eszopiclone
Eszopiclone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Rosiglitazone
Rosiglitazone {u} (Compound) resembles {v} (Compound) Tripelennamine
Ropinirole {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Tripelennamine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Risperidone
Risperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Ropinirole {u} (Compound) binds {v} (Gene) ADRA2C
ADRA2C {u} (Gene) is bound by {v} (Compound) Pramipexole
Pramipexole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tripelennamine (Compound)
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Chloropyramine (Compound) and Chloropyramine (Compound) resembles Tripelennamine (Compound)
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Brompheniramine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Tripelennamine
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Eszopiclone (Compound) and Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Rosiglitazone (Compound) and Rosiglitazone (Compound) resembles Tripelennamine (Compound)
Ropinirole (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Promazine (Compound) and Promazine (Compound) resembles Tripelennamine (Compound)
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Risperidone (Compound) and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ropinirole (Compound) binds ADRA2C (Gene) and ADRA2C (Gene) is bound by Pramipexole (Compound) and Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine