DDInter1834 DDInter517
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Dexbrompheniramine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) resembles {v} (Compound) Dexbrompheniramine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Zonisamide
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Dexbrompheniramine
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Chloropyramine
Chloropyramine {u} (Compound) resembles {v} (Compound) Dexbrompheniramine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Ipratropium
Ipratropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Topiramate {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Dexbrompheniramine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Topiramate (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Topiramate (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Dexbrompheniramine (Compound)
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Topiramate (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Chloropyramine (Compound) and Chloropyramine (Compound) resembles Dexbrompheniramine (Compound)
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Zonisamide (Compound) and Zonisamide may lead to a major life threatening interaction when taken with Dexbrompheniramine
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Chloropyramine (Compound) and Chloropyramine (Compound) resembles Dexbrompheniramine (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ipratropium (Compound) and Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Topiramate (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Dexbrompheniramine (Compound)