DDInter1647 DDInter1544
Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analogue, scopolamine can antagonize muscarinic acetylcholine receptors (mAChRs) in the central nervous system and throughout the body, inducing several therapeutic and adverse effects related to alteration of parasympathetic nervous system and cholinergic signalling.[A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981.[A228423,
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Scopolamine {u} (Compound) resembles {v} (Compound) Homatropine Methylbromide
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Scopolamine {u} (Compound) resembles {v} (Compound) Methylscopolamine bromide
Scopolamine {u} (Compound) binds {v} (Gene) CHRM4
Scopolamine {u} (Compound) upregulates {v} (Gene) MCOLN1
Scopolamine {u} (Compound) causes {v} (Side Effect) Photophobia
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metolazone
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nadolol
Scopolamine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Scopolamine (Compound) resembles Homatropine Methylbromide (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Scopolamine (Compound) resembles Methylscopolamine bromide (Compound)
Scopolamine (Compound) binds CHRM4 (Gene)
Scopolamine (Compound) upregulates MCOLN1 (Gene)
Scopolamine (Compound) causes Photophobia (Side Effect)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Metolazone
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Phenelzine
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol
Scopolamine may lead to a major life threatening interaction when taken with Potassium chloride