DDInter906 DDInter178
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Ifosfamide {u} (Compound) treats {v} (Disease) testicular cancer
Ifosfamide {u} (Compound) binds {v} (Gene) CYP2A6
Ifosfamide {u} (Compound) upregulates {v} (Gene) UBQLN2
Ifosfamide {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Ifosfamide {u} (Compound) downregulates {v} (Gene) STUB1
Ifosfamide {u} (Compound) causes {v} (Side Effect) Palpitations
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Ifosfamide (Compound) treats testicular cancer (Disease)
Ifosfamide (Compound) binds CYP2A6 (Gene)
Ifosfamide (Compound) upregulates UBQLN2 (Gene)
Ifosfamide (Compound) is included by Alkylating Activity (Pharmacologic Class)
Ifosfamide (Compound) downregulates STUB1 (Gene)
Ifosfamide (Compound) causes Palpitations (Side Effect)
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Quazepam