DDInter154 DDInter1933
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active. It was first introduced as an antiepileptic agent in the United Kingdom in 1989 and was used extensively until 1997, when an association with vision loss became apparent. Its use is now generally reserved for patients who have failed alternative therapies, and its US approval by the FDA in 2009 mandated the creation of a drug registry to monitor patients for visual deficits.[L13661,A202124]
Azelastine {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Vigabatrin
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vigabatrin
Azelastine {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Promethazine
Promethazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vigabatrin
Azelastine {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) L-Glutamine
L-Glutamine {u} (Compound) resembles {v} (Compound) Vigabatrin
Azelastine {u} (Compound) causes {v} (Side Effect) Nasopharyngitis
Nasopharyngitis {u} (Side Effect) is caused by {v} (Compound) Carglumic Acid
Carglumic Acid {u} (Compound) resembles {v} (Compound) Vigabatrin
Azelastine {u} (Compound) causes {v} (Side Effect) Throat irritation
Throat irritation {u} (Side Effect) is caused by {v} (Compound) Budesonide
Budesonide {u} may lead to a major life threatening interaction when taken with {v} Vigabatrin
Azelastine {u} (Compound) causes {v} (Side Effect) Pharyngolaryngeal pain
Pharyngolaryngeal pain {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vigabatrin
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Vigabatrin
Azelastine {u} (Compound) causes {v} (Side Effect) Throat irritation
Throat irritation {u} (Side Effect) is caused by {v} (Compound) Tamoxifen
Tamoxifen {u} may lead to a major life threatening interaction when taken with {v} Vigabatrin
Azelastine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vigabatrin
Azelastine (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Vigabatrin (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Azelastine (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Promethazine (Compound) and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Azelastine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by L-Glutamine (Compound) and L-Glutamine (Compound) resembles Vigabatrin (Compound)
Azelastine (Compound) causes Nasopharyngitis (Side Effect) and Nasopharyngitis (Side Effect) is caused by Carglumic Acid (Compound) and Carglumic Acid (Compound) resembles Vigabatrin (Compound)
Azelastine (Compound) causes Throat irritation (Side Effect) and Throat irritation (Side Effect) is caused by Budesonide (Compound) and Budesonide may lead to a major life threatening interaction when taken with Vigabatrin
Azelastine (Compound) causes Pharyngolaryngeal pain (Side Effect) and Pharyngolaryngeal pain (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin
Azelastine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Vigabatrin (Compound)
Azelastine (Compound) causes Throat irritation (Side Effect) and Throat irritation (Side Effect) is caused by Tamoxifen (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Vigabatrin
Azelastine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Vigabatrin