DDInter458 DDInter1451
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter&#39;s syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenylbutazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Phenylbutazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Phenylbutazone
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Gentamicin
Gentamicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutazone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Phenylbutazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Phenylbutazone
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Streptomycin
Streptomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) regulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is upregulated by {v} (Compound) Phenylbutazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenylbutazone
Cyclosporine {u} (Compound) downregulates {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Vemurafenib
Vemurafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutazone
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenylbutazone (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methadone (Compound) and Methadone (Compound) resembles Phenylbutazone (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Alverine (Compound) and Alverine (Compound) resembles Phenylbutazone (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Gentamicin (Compound) and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Phenylbutazone (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by PTGS2 (Gene) and PTGS2 (Gene) is bound by Phenylbutazone (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound) and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) regulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Phenylbutazone (Compound)
Cyclosporine (Compound) downregulates TYMS (Gene) and TYMS (Gene) is downregulated by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Phenylbutazone
Cyclosporine (Compound) downregulates TYMS (Gene) and TYMS (Gene) is downregulated by Vemurafenib (Compound) and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone