DDInter652 DDInter1376
Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new products/biosimilars and dosage routes have been approved under various names over the last several decades,,. On August 16, 2018, Teva Pharmaceuticals USA gained approval to market its generic epinephrine auto-injector in 0.3 mg and 0.15 mg strengths. Dosage delivery routes for epinephrine include intravenous, inhalation, nebulization, intramuscular injection, and subcutaneous injection. In general, the most common uses of parenteral epinephrine are to relieve respiratory distress due to
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Epinephrine {u} (Compound) resembles {v} (Compound) Phenylephrine
Epinephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Droxidopa
Epinephrine {u} (Compound) binds {v} (Gene) ADRB2
Epinephrine {u} (Compound) upregulates {v} (Gene) TF
Epinephrine {u} (Compound) palliates {v} (Disease) glaucoma
Epinephrine {u} (Compound) is included by {v} (Pharmacologic Class) Catecholamines
Epinephrine {u} (Compound) downregulates {v} (Gene) PIK3C2B
Epinephrine {u} (Compound) causes {v} (Side Effect) Drug interaction
Epinephrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lithium carbonate
Epinephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amphetamine
Epinephrine (Compound) resembles Phenylephrine (Compound)
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Droxidopa
Epinephrine (Compound) binds ADRB2 (Gene)
Epinephrine (Compound) upregulates TF (Gene)
Epinephrine (Compound) palliates glaucoma (Disease)
Epinephrine (Compound) is included by Catecholamines (Pharmacologic Class)
Epinephrine (Compound) downregulates PIK3C2B (Gene)
Epinephrine (Compound) causes Drug interaction (Side Effect)
Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine