DDInter576 DDInter534
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 . Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect . This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy .
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Numbness
Numbness {u} (Side Effect) is caused by {v} (Compound) Diazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Oxazepam
Oxazepam {u} (Compound) resembles {v} (Compound) Diazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Numbness
Numbness {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Diazepam
Disulfiram {u} (Compound) causes {v} (Side Effect) Drowsiness
Drowsiness {u} (Side Effect) is caused by {v} (Compound) Quazepam
Quazepam {u} (Compound) resembles {v} (Compound) Diazepam
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) resembles {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Diazepam
Disulfiram {u} (Compound) upregulates {v} (Gene) DUSP5
DUSP5 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Diazepam
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is palliated by {v} (Compound) Chlordiazepoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Diazepam
Disulfiram {u} (Compound) upregulates {v} (Gene) CTSL
CTSL {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Diazepam
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diazepam (Compound)
Disulfiram (Compound) causes Numbness (Side Effect) and Numbness (Side Effect) is caused by Diazepam (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quazepam (Compound) and Quazepam (Compound) resembles Diazepam (Compound)
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Oxazepam (Compound) and Oxazepam (Compound) resembles Diazepam (Compound)
Disulfiram (Compound) causes Numbness (Side Effect) and Numbness (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Diazepam (Compound)
Disulfiram (Compound) causes Drowsiness (Side Effect) and Drowsiness (Side Effect) is caused by Quazepam (Compound) and Quazepam (Compound) resembles Diazepam (Compound)
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) resembles panic disorder (Disease) and panic disorder (Disease) is palliated by Diazepam (Compound)
Disulfiram (Compound) upregulates DUSP5 (Gene) and DUSP5 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Diazepam (Compound)
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is palliated by Chlordiazepoxide (Compound) and Chlordiazepoxide (Compound) resembles Diazepam (Compound)
Disulfiram (Compound) upregulates CTSL (Gene) and CTSL (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Diazepam (Compound)