DDInter1522 DDInter856
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Probenecid {u} (Compound) resembles {v} (Compound) Sulfacetamide
Probenecid {u} (Compound) resembles {v} (Compound) Procainamide
Probenecid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolbutamide
Probenecid {u} (Compound) treats {v} (Disease) gout
Probenecid {u} (Compound) binds {v} (Gene) ABCC2
Probenecid {u} (Compound) downregulates {v} (Gene) ARNT2
Probenecid {u} (Compound) causes {v} (Side Effect) Nephrotic syndrome
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Famotidine
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Eluxadoline
Probenecid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Probenecid (Compound) resembles Sulfacetamide (Compound)
Probenecid (Compound) resembles Procainamide (Compound)
Probenecid may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide
Probenecid (Compound) treats gout (Disease)
Probenecid (Compound) binds ABCC2 (Gene)
Probenecid (Compound) downregulates ARNT2 (Gene)
Probenecid (Compound) causes Nephrotic syndrome (Side Effect)
Probenecid may cause a minor interaction that can limit clinical effects when taken with Famotidine
Probenecid may cause a minor interaction that can limit clinical effects when taken with Eluxadoline
Probenecid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid