DDInter1266 DDInter1559
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Naproxen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Rabeprazole
Naproxen {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Rabeprazole
Naproxen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Naproxen {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Lansoprazole
Lansoprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Naproxen {u} (Compound) causes {v} (Side Effect) Metrorrhagia
Metrorrhagia {u} (Side Effect) is caused by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rabeprazole
Naproxen {u} (Compound) causes {v} (Side Effect) Thrombophlebitis
Thrombophlebitis {u} (Side Effect) is caused by {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Naproxen {u} (Compound) causes {v} (Side Effect) Drug eruption
Drug eruption {u} (Side Effect) is caused by {v} (Compound) Raltegravir
Raltegravir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rabeprazole
Naproxen {u} (Compound) causes {v} (Side Effect) Coma
Coma {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rabeprazole
Naproxen {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Rabeprazole
Naproxen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Omeprazole
Omeprazole {u} (Compound) resembles {v} (Compound) Rabeprazole
Naproxen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Rabeprazole (Compound)
Naproxen (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Rabeprazole (Compound)
Naproxen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Naproxen (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Lansoprazole (Compound) and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Naproxen (Compound) causes Metrorrhagia (Side Effect) and Metrorrhagia (Side Effect) is caused by Mycophenolate mofetil (Compound) and Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole
Naproxen (Compound) causes Thrombophlebitis (Side Effect) and Thrombophlebitis (Side Effect) is caused by Pantoprazole (Compound) and Pantoprazole (Compound) resembles Rabeprazole (Compound)
Naproxen (Compound) causes Drug eruption (Side Effect) and Drug eruption (Side Effect) is caused by Raltegravir (Compound) and Raltegravir may cause a minor interaction that can limit clinical effects when taken with Rabeprazole
Naproxen (Compound) causes Coma (Side Effect) and Coma (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Rabeprazole
Naproxen (Compound) resembles Suprofen (Compound) and Suprofen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Rabeprazole (Compound)
Naproxen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Omeprazole (Compound) and Omeprazole (Compound) resembles Rabeprazole (Compound)