DDInter1627 DDInter1155
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions.
Rufinamide {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Levetiracetam
Levetiracetam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Rufinamide {u} (Compound) binds {v} (Gene) SCN7A
SCN7A {u} (Gene) is bound by {v} (Compound) Ethotoin
Ethotoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Rufinamide {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Mepyramine
Rufinamide {u} (Compound) binds {v} (Gene) SCN2A
SCN2A {u} (Gene) is bound by {v} (Compound) Zonisamide
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Mepyramine
Rufinamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Mepyramine
Rufinamide {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Rufinamide {u} (Compound) binds {v} (Gene) CES1
CES1 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Mepyramine
Rufinamide {u} (Compound) binds {v} (Gene) CES1
CES1 {u} (Gene) is regulated by {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Mepyramine
Rufinamide {u} (Compound) binds {v} (Gene) CES1
CES1 {u} (Gene) is upregulated by {v} (Compound) Terazosin
Terazosin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepyramine
Rufinamide {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Zonisamide
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Mepyramine
Rufinamide (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Levetiracetam (Compound) and Levetiracetam may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Rufinamide (Compound) binds SCN7A (Gene) and SCN7A (Gene) is bound by Ethotoin (Compound) and Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Rufinamide (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Rufinamide (Compound) binds SCN2A (Gene) and SCN2A (Gene) is bound by Zonisamide (Compound) and Zonisamide may lead to a major life threatening interaction when taken with Mepyramine
Rufinamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Diltiazem (Compound) and Diltiazem (Compound) resembles Mepyramine (Compound)
Rufinamide (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Rufinamide (Compound) binds CES1 (Gene) and CES1 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Mepyramine (Compound)
Rufinamide (Compound) binds CES1 (Gene) and CES1 (Gene) is regulated by PAK1 (Gene) and PAK1 (Gene) is upregulated by Mepyramine (Compound)
Rufinamide (Compound) binds CES1 (Gene) and CES1 (Gene) is upregulated by Terazosin (Compound) and Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Rufinamide (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Zonisamide (Compound) and Zonisamide may lead to a major life threatening interaction when taken with Mepyramine