DDInter1619 DDInter1873
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Ropinirole {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Trimethobenzamide
Ropinirole {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Midazolam
Midazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Ropinirole {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Papaverine
Papaverine {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Papaverine
Papaverine {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Ropinirole {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Iloperidone
Iloperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Ropinirole {u} (Compound) binds {v} (Gene) HTR2B
HTR2B {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Ropinirole {u} (Compound) binds {v} (Gene) HTR2B
HTR2B {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Verapamil
Verapamil {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Ropinirole {u} (Compound) binds {v} (Gene) HTR2B
HTR2B {u} (Gene) is bound by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethobenzamide
Ropinirole (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Trimethobenzamide (Compound)
Ropinirole (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Ropinirole (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Papaverine (Compound) and Papaverine (Compound) resembles Trimethobenzamide (Compound)
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Papaverine (Compound) and Papaverine (Compound) resembles Trimethobenzamide (Compound)
Ropinirole (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Iloperidone (Compound) and Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Ropinirole (Compound) binds HTR2B (Gene) and HTR2B (Gene) is bound by Cisapride (Compound) and Cisapride (Compound) resembles Trimethobenzamide (Compound)
Ropinirole (Compound) binds HTR2B (Gene) and HTR2B (Gene) is bound by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Verapamil (Compound) and Verapamil (Compound) resembles Trimethobenzamide (Compound)
Ropinirole (Compound) binds HTR2B (Gene) and HTR2B (Gene) is bound by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Trimethobenzamide