DDInter722 DDInter1376
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily. Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Fentanyl {u} (Compound) resembles {v} (Compound) Modafinil
Fentanyl {u} (Compound) resembles {v} (Compound) Aprindine
Fentanyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Fentanyl {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
Fentanyl {u} (Compound) palliates {v} (Disease) prostate cancer
Fentanyl {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Fentanyl {u} (Compound) causes {v} (Side Effect) Drug hypersensitivity
Fentanyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Certolizumab pegol
Fentanyl {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Fentanyl {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Fentanyl (Compound) resembles Modafinil (Compound)
Fentanyl (Compound) resembles Aprindine (Compound)
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Fentanyl (Compound) binds CYP3A7-CYP3A51P (Gene)
Fentanyl (Compound) palliates prostate cancer (Disease)
Fentanyl (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Fentanyl (Compound) causes Drug hypersensitivity (Side Effect)
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Fentanyl may lead to a major life threatening interaction when taken with Iohexol
Fentanyl may lead to a major life threatening interaction when taken with Dolasetron