DDInter932 DDInter130
Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis. Insulin is an important treatment in the management of Type 1 Diabetes (T1D), which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review of patients being treated for primary hypertension shows that atenolol shows a risk ratio of 0.88 for cardiovascular disease risk and a risk ratio of 0.99 for mortality.[A235850,A235855] Similar results have been found in other meta-analyses.[A235860,A235865] A meta-analysis of over 145,000 patients showed the risk of stroke in patients taking atenolol may depend on the age of the patient. The use of atenolol may need to be based on more patient factors than hypertension alone.[A235850,A235855,A235860,A235865]
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoprolol
Metoprolol {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} (Compound) resembles {v} (Compound) Practolol
Practolol {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Practolol
Practolol {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Penbutolol
Penbutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sotalol
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procarbazine
Procarbazine {u} (Compound) resembles {v} (Compound) Atenolol
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Oxprenolol (Compound) and Oxprenolol (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Compound) resembles Practolol (Compound) and Practolol (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Oxprenolol (Compound) and Oxprenolol (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Practolol (Compound) and Practolol (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol (Compound) resembles Ibuprofen (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Atenolol (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sotalol and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Atenolol (Compound)