DDInter1312 DDInter690
Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol]. Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency, and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.[L9527,L10301,L10304,L10307] First derived in 1951 in Mexico City, norethisterone was originally intended for use as a remedy for irregular menstruation and endometriosis, and was not marketed for use as an oral contraceptive until 1962.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Norethisterone {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Miconazole
Miconazole {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} (Compound) resembles {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluconazole
Fluconazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rosuvastatin
Rosuvastatin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Bexarotene {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} may lead to a major life threatening interaction when taken with {v} Dabrafenib
Dabrafenib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} (Compound) upregulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) interacts with {v} (Gene) ADH1B
ADH1B {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone {u} (Compound) palliates {v} (Disease) polycystic ovary syndrome
polycystic ovary syndrome {u} (Disease) upregulates {v} (Gene) GLRA2
GLRA2 {u} (Gene) is bound by {v} (Compound) Ethanol
Norethisterone (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Norethisterone (Compound) resembles Testosterone (Compound) and Testosterone (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Norethisterone (Compound) resembles Ethinylestradiol (Compound) and Ethinylestradiol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ethanol (Compound)
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Norethisterone may cause a minor interaction that can limit clinical effects when taken with Rosuvastatin and Rosuvastatin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethanol (Compound)
Norethisterone may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Norethisterone may lead to a major life threatening interaction when taken with Dabrafenib and Dabrafenib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ethanol (Compound)
Norethisterone (Compound) upregulates SERPINA3 (Gene) and SERPINA3 (Gene) interacts with ADH1B (Gene) and ADH1B (Gene) is bound by Ethanol (Compound)
Norethisterone (Compound) palliates polycystic ovary syndrome (Disease) and polycystic ovary syndrome (Disease) upregulates GLRA2 (Gene) and GLRA2 (Gene) is bound by Ethanol (Compound)