DDInter268 DDInter883
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.
Calcitriol {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Calcitriol {u} (Compound) downregulates {v} (Gene) PRPF4
PRPF4 {u} (Gene) is downregulated by {v} (Compound) Hydrochlorothiazide
Calcitriol {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Hydrochlorothiazide
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrochlorothiazide
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrochlorothiazide
Calcitriol {u} (Compound) upregulates {v} (Gene) CCDC92
CCDC92 {u} (Gene) regulates {v} (Gene) WIF1
WIF1 {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Calcitriol {u} (Compound) downregulates {v} (Gene) PRPF4
PRPF4 {u} (Gene) is regulated by {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Hydrochlorothiazide
Calcitriol {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is regulated by {v} (Gene) CFLAR
CFLAR {u} (Gene) is upregulated by {v} (Compound) Hydrochlorothiazide
Calcitriol {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Scopolamine
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydrochlorothiazide
Calcitriol {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Diclofenamide
Diclofenamide {u} (Compound) resembles {v} (Compound) Hydrochlorothiazide
Calcitriol (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) is upregulated by Hydrochlorothiazide (Compound)
Calcitriol (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is downregulated by Hydrochlorothiazide (Compound)
Calcitriol (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Hydrochlorothiazide (Compound)
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide
Calcitriol (Compound) upregulates CCDC92 (Gene) and CCDC92 (Gene) regulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Hydrochlorothiazide (Compound)
Calcitriol (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is regulated by CA12 (Gene) and CA12 (Gene) is bound by Hydrochlorothiazide (Compound)
Calcitriol (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is regulated by CFLAR (Gene) and CFLAR (Gene) is upregulated by Hydrochlorothiazide (Compound)
Calcitriol (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Scopolamine (Compound) and Scopolamine may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide
Calcitriol (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Diclofenamide (Compound) and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)