DDInter192 DDInter1376
A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Bepridil {u} (Compound) resembles {v} (Compound) Diphenidol
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Bepridil {u} (Compound) resembles {v} (Compound) Fentanyl
Bepridil {u} (Compound) treats {v} (Disease) hypertension
Bepridil {u} (Compound) binds {v} (Gene) CACNA1D
Bepridil {u} (Compound) causes {v} (Side Effect) Insomnia
Bepridil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Bepridil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcium glubionate anhydrous
Bepridil {u} may lead to a major life threatening interaction when taken with {v} Eliglustat
Bepridil (Compound) resembles Diphenidol (Compound)
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Bepridil (Compound) resembles Fentanyl (Compound)
Bepridil (Compound) treats hypertension (Disease)
Bepridil (Compound) binds CACNA1D (Gene)
Bepridil (Compound) causes Insomnia (Side Effect)
Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Bepridil may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Bepridil may lead to a major life threatening interaction when taken with Eliglustat