DDInter1867 DDInter1088
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxylate] and [haloperidol]. Due to pharmacological properties, loperamide has been misused and abused to self-manage opioid withdrawal symptoms and to induce euphoria.[A251610, A251625] However, loperamide is associated with a risk for experiencing a range of adverse effects, often life-threatening, if taking for non-therapeutic reasons or at doses higher than the recommended dose.
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Loperamide
Triflupromazine {u} (Compound) upregulates {v} (Gene) SQLE
SQLE {u} (Gene) is upregulated by {v} (Compound) Loperamide
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Triflupromazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Loperamide
Triflupromazine {u} (Compound) upregulates {v} (Gene) SQLE
SQLE {u} (Gene) is upregulated by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Triflupromazine {u} (Compound) upregulates {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Clotrimazole {u} (Compound) resembles {v} (Compound) Loperamide
Triflupromazine {u} (Compound) upregulates {v} (Gene) LDLR
LDLR {u} (Gene) regulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Triflupromazine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Loperamide (Compound)
Triflupromazine (Compound) upregulates SQLE (Gene) and SQLE (Gene) is upregulated by Loperamide (Compound)
Triflupromazine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Loperamide (Compound)
Triflupromazine (Compound) resembles Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Triflupromazine (Compound) resembles Methdilazine (Compound) and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Loperamide (Compound)
Triflupromazine (Compound) upregulates SQLE (Gene) and SQLE (Gene) is upregulated by Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Triflupromazine (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is bound by Clotrimazole (Compound) and Clotrimazole (Compound) resembles Loperamide (Compound)
Triflupromazine (Compound) upregulates LDLR (Gene) and LDLR (Gene) regulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Loperamide (Compound)
Triflupromazine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Loperamide