DDInter458 DDInter1612
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. [Sugammadex] is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Rocuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Rocuronium
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rocuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Amphotericin B
Amphotericin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rocuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Rocuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hiccups
Hiccups {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rocuronium
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Rocuronium
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Quinine
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rocuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hiccups
Hiccups {u} (Side Effect) is caused by {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rocuronium
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rocuronium
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Rocuronium (Compound)
Cyclosporine (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Rocuronium (Compound)
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium
Cyclosporine (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Amphotericin B (Compound) and Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium
Cyclosporine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Vecuronium (Compound) and Vecuronium (Compound) resembles Rocuronium (Compound)
Cyclosporine (Compound) causes Hiccups (Side Effect) and Hiccups (Side Effect) is caused by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Rocuronium
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Vecuronium (Compound) and Vecuronium (Compound) resembles Rocuronium (Compound)
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Quinine (Compound) and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium
Cyclosporine (Compound) causes Hiccups (Side Effect) and Hiccups (Side Effect) is caused by Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Rocuronium