DDInter1796 DDInter1055
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618). Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Thioridazine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) downregulates {v} (Gene) ACD
ACD {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) downregulates {v} (Gene) ACD
ACD {u} (Gene) is downregulated by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) causes {v} (Side Effect) Hyperkinesia
Hyperkinesia {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Thioridazine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Thioridazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Thioridazine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)
Thioridazine (Compound) downregulates ACD (Gene) and ACD (Gene) is downregulated by Levofloxacin (Compound)
Thioridazine (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Thioridazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Levofloxacin (Compound)
Thioridazine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Thioridazine (Compound) downregulates ACD (Gene) and ACD (Gene) is downregulated by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Thioridazine (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Thioridazine (Compound) causes Hyperkinesia (Side Effect) and Hyperkinesia (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Thioridazine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Enoxacin (Compound) and Enoxacin (Compound) resembles Levofloxacin (Compound)