DDInter1833 DDInter1544
Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Tolvaptan {u} (Compound) resembles {v} (Compound) Conivaptan
Tolvaptan {u} (Compound) binds {v} (Gene) AVPR1A
Tolvaptan {u} (Compound) causes {v} (Side Effect) Renal impairment
Tolvaptan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Tolvaptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Empagliflozin
Tolvaptan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naltrexone
Tolvaptan {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Tolvaptan {u} may lead to a major life threatening interaction when taken with {v} Lumacaftor
Tolvaptan (Compound) resembles Conivaptan (Compound)
Tolvaptan (Compound) binds AVPR1A (Gene)
Tolvaptan (Compound) causes Renal impairment (Side Effect)
Tolvaptan may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Tolvaptan may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone
Tolvaptan may lead to a major life threatening interaction when taken with Leflunomide
Tolvaptan may lead to a major life threatening interaction when taken with Lumacaftor