DDInter268 DDInter1423
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) upregulates {v} (Gene) TSPAN3
TSPAN3 {u} (Gene) is downregulated by {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentobarbital
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentobarbital
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Thiopental
Thiopental {u} (Compound) resembles {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) upregulates {v} (Gene) TSPAN3
TSPAN3 {u} (Gene) regulates {v} (Gene) FABP5
FABP5 {u} (Gene) is downregulated by {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Butabarbital
Butabarbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pentobarbital (Compound)
Calcitriol (Compound) upregulates TSPAN3 (Gene) and TSPAN3 (Gene) is downregulated by Pentobarbital (Compound)
Calcitriol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pentobarbital (Compound)
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital
Calcitriol (Compound) resembles Paricalcitol (Compound) and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Thiopental (Compound) and Thiopental (Compound) resembles Pentobarbital (Compound)
Calcitriol (Compound) upregulates TSPAN3 (Gene) and TSPAN3 (Gene) regulates FABP5 (Gene) and FABP5 (Gene) is downregulated by Pentobarbital (Compound)
Calcitriol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Butabarbital (Compound) and Butabarbital (Compound) resembles Pentobarbital (Compound)
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Butalbital (Compound) resembles Pentobarbital (Compound)
Calcitriol (Compound) resembles Paricalcitol (Compound) and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Butalbital (Compound) resembles Pentobarbital (Compound)