DDInter255 DDInter1638
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium Sm 153 lexidronam is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive samarium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain.
Busulfan {u} (Compound) causes {v} (Side Effect) Blood urea increased
Blood urea increased {u} (Side Effect) is caused by {v} (Compound) Foscarnet
Foscarnet {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) causes {v} (Side Effect) Blood urea increased
Blood urea increased {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) causes {v} (Side Effect) Blood urea increased
Blood urea increased {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Ganciclovir
Ganciclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Lenalidomide
Lenalidomide {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Altretamine
Altretamine {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bexarotene
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Samarium (153Sm) lexidronam
Busulfan (Compound) causes Blood urea increased (Side Effect) and Blood urea increased (Side Effect) is caused by Foscarnet (Compound) and Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) causes Blood urea increased (Side Effect) and Blood urea increased (Side Effect) is caused by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) causes Blood urea increased (Side Effect) and Blood urea increased (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Ganciclovir (Compound) and Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Lenalidomide (Compound) and Lenalidomide may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Altretamine (Compound) and Altretamine may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound) and Bexarotene may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Busulfan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam