DDInter1936 DDInter596
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epirubicin
Epirubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) downregulates {v} (Gene) AKR1C3
AKR1C3 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) upregulates {v} (Gene) RSU1
RSU1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) downregulates {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) downregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) upregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Vinblastine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin (Compound) resembles Doxorubicin (Compound)
Vinblastine (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Doxorubicin (Compound)
Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxorubicin (Compound)
Vinblastine (Compound) downregulates AKR1C3 (Gene) and AKR1C3 (Gene) is bound by Doxorubicin (Compound)
Vinblastine (Compound) upregulates RSU1 (Gene) and RSU1 (Gene) is upregulated by Doxorubicin (Compound)
Vinblastine (Compound) downregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Doxorubicin (Compound)
Vinblastine (Compound) downregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Doxorubicin (Compound)
Vinblastine (Compound) upregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Doxorubicin (Compound)
Vinblastine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Doxorubicin (Compound)