DDInter336 DDInter1945
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expressed on platelets, vorapaxar prevents thrombin-related platelet aggregation.
Celecoxib {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Pentosan polysulfate
Pentosan polysulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorapaxar
Celecoxib {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Nabumetone
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fluvoxamine
Fluvoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorapaxar
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Phenylbutazone
Phenylbutazone {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorapaxar
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Meloxicam
Meloxicam {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Icosapent
Icosapent {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorapaxar
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vorapaxar
Celecoxib {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may lead to a major life threatening interaction when taken with {v} Vorapaxar
Celecoxib (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Pentosan polysulfate (Compound) and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Celecoxib (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Nabumetone (Compound) and Nabumetone may lead to a major life threatening interaction when taken with Vorapaxar
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fluvoxamine (Compound) and Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Phenylbutazone (Compound) and Phenylbutazone may lead to a major life threatening interaction when taken with Vorapaxar
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Meloxicam (Compound) and Meloxicam may lead to a major life threatening interaction when taken with Vorapaxar
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Icosapent (Compound) and Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Vorapaxar
Celecoxib (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Vorapaxar
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Vorapaxar