DDInter1397 DDInter105
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Paroxetine {u} (Compound) binds {v} (Gene) CHRM5
Paroxetine {u} (Compound) upregulates {v} (Gene) CSTA
Paroxetine {u} (Compound) palliates {v} (Disease) panic disorder
Paroxetine {u} (Compound) downregulates {v} (Gene) GRWD1
Paroxetine {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Paroxetine (Compound) binds CHRM5 (Gene)
Paroxetine (Compound) upregulates CSTA (Gene)
Paroxetine (Compound) palliates panic disorder (Disease)
Paroxetine (Compound) downregulates GRWD1 (Gene)
Paroxetine (Compound) causes Anaphylactoid reaction (Side Effect)