DDInter1355 DDInter875
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The
Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant *Saccharomyces cerevisiae* and self-assembled into VLPs.
Oxaliplatin {u} (Compound) binds {v} (Gene) ATP7B
Oxaliplatin {u} (Compound) is included by {v} (Pharmacologic Class) Platinum-containing Compounds
Oxaliplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Floxuridine
Oxaliplatin {u} may lead to a major life threatening interaction when taken with {v} Escitalopram
Oxaliplatin {u} may lead to a major life threatening interaction when taken with {v} Dofetilide
Oxaliplatin (Compound) binds ATP7B (Gene)
Oxaliplatin (Compound) is included by Platinum-containing Compounds (Pharmacologic Class)
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine
Oxaliplatin may lead to a major life threatening interaction when taken with Escitalopram
Oxaliplatin may lead to a major life threatening interaction when taken with Dofetilide