DDInter1853 DDInter1705
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is regulated by {v} (Gene) KCTD5
KCTD5 {u} (Gene) is upregulated by {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) GHR
GHR {u} (Gene) is upregulated by {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Blepharitis
Blepharitis {u} (Side Effect) is caused by {v} (Compound) Hydroxyurea
Hydroxyurea {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) regulates {v} (Gene) WRB
WRB {u} (Gene) is upregulated by {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) causes {v} (Side Effect) Sensory disturbance
Sensory disturbance {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Sparfloxacin
Tretinoin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) PHKA1
PHKA1 {u} (Gene) is downregulated by {v} (Compound) Sparfloxacin
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Sparfloxacin (Compound)
Tretinoin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Sparfloxacin (Compound)
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is regulated by KCTD5 (Gene) and KCTD5 (Gene) is upregulated by Sparfloxacin (Compound)
Tretinoin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with GHR (Gene) and GHR (Gene) is upregulated by Sparfloxacin (Compound)
Tretinoin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Tretinoin (Compound) causes Blepharitis (Side Effect) and Blepharitis (Side Effect) is caused by Hydroxyurea (Compound) and Hydroxyurea may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Tretinoin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) regulates WRB (Gene) and WRB (Gene) is upregulated by Sparfloxacin (Compound)
Tretinoin (Compound) causes Sensory disturbance (Side Effect) and Sensory disturbance (Side Effect) is caused by Paclitaxel (Compound) and Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Sparfloxacin (Compound)
Tretinoin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by PHKA1 (Gene) and PHKA1 (Gene) is downregulated by Sparfloxacin (Compound)