DDInter576 DDInter98
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Anisindione
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Simvastatin
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Disulfiram {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Anisindione
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Erlotinib
Erlotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Bicalutamide
Bicalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Anisindione
Disulfiram {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Menadione
Menadione {u} (Compound) resembles {v} (Compound) Anisindione
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Acarbose
Acarbose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Disulfiram {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diltiazem (Compound) and Diltiazem (Compound) resembles Anisindione (Compound)
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Simvastatin (Compound) and Simvastatin may cause a minor interaction that can limit clinical effects when taken with Anisindione
Disulfiram (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Diltiazem (Compound) and Diltiazem (Compound) resembles Anisindione (Compound)
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Erlotinib (Compound) and Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bicalutamide (Compound) and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione
Disulfiram (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Diltiazem (Compound) and Diltiazem (Compound) resembles Anisindione (Compound)
Disulfiram (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Menadione (Compound) and Menadione (Compound) resembles Anisindione (Compound)
Disulfiram (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Acarbose (Compound) and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione
Disulfiram (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Anisindione