DDInter1639 DDInter989
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Sapropterin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Isosorbide dinitrate
Sapropterin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Isosorbide mononitrate
Isosorbide mononitrate {u} (Compound) resembles {v} (Compound) Isosorbide dinitrate
Sapropterin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide dinitrate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) interacts with {v} (Gene) NOSIP
NOSIP {u} (Gene) is downregulated by {v} (Compound) Isosorbide dinitrate
Sapropterin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Dapagliflozin
Dapagliflozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide dinitrate
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Dapsone
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide dinitrate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) interacts with {v} (Gene) GUCY1B3
GUCY1B3 {u} (Gene) is bound by {v} (Compound) Isosorbide dinitrate
Sapropterin {u} (Compound) upregulates {v} (Gene) GNAI1
GNAI1 {u} (Gene) regulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Isosorbide dinitrate
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is palliated by {v} (Compound) Isosorbide dinitrate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is regulated by {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Isosorbide dinitrate
Sapropterin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Isosorbide dinitrate (Compound)
Sapropterin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Isosorbide mononitrate (Compound) and Isosorbide mononitrate (Compound) resembles Isosorbide dinitrate (Compound)
Sapropterin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Morphine (Compound) and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide dinitrate
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) interacts with NOSIP (Gene) and NOSIP (Gene) is downregulated by Isosorbide dinitrate (Compound)
Sapropterin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Dapagliflozin (Compound) and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide dinitrate
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Dapsone (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide dinitrate
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) interacts with GUCY1B3 (Gene) and GUCY1B3 (Gene) is bound by Isosorbide dinitrate (Compound)
Sapropterin (Compound) upregulates GNAI1 (Gene) and GNAI1 (Gene) regulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Isosorbide dinitrate (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is palliated by Isosorbide dinitrate (Compound)
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is regulated by PROS1 (Gene) and PROS1 (Gene) is upregulated by Isosorbide dinitrate (Compound)