DDInter1764 DDInter1397
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxetine
Fluoxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentosan polysulfate
Pentosan polysulfate {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) downregulates {v} (Gene) TIMELESS
TIMELESS {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvoxamine
Fluvoxamine {u} (Compound) downregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvoxamine
Fluvoxamine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cilostazol
Cilostazol {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Icosapent
Icosapent {u} (Compound) binds {v} (Gene) FADS1
FADS1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tenecteplase {u} may lead to a major life threatening interaction when taken with {v} Rivaroxaban
Rivaroxaban {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Tenecteplase {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Enoxaparin {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) downregulates TIMELESS (Gene) and TIMELESS (Gene) is downregulated by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine (Compound) downregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is downregulated by Paroxetine (Compound)
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Icosapent and Icosapent (Compound) binds FADS1 (Gene) and FADS1 (Gene) is upregulated by Paroxetine (Compound)
Tenecteplase may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Tenecteplase may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Paroxetine (Compound)