DDInter1042 DDInter779
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Foscarnet {u} (Compound) binds {v} (Gene) SLC22A6
Foscarnet {u} (Compound) is included by {v} (Pharmacologic Class) DNA Polymerase Inhibitors
Foscarnet {u} (Compound) causes {v} (Side Effect) Blood urea increased
Foscarnet {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Foscarnet {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Palonosetron
Foscarnet {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Foscarnet {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Foscarnet {u} may lead to a major life threatening interaction when taken with {v} Anagrelide
Foscarnet (Compound) binds SLC22A6 (Gene)
Foscarnet (Compound) is included by DNA Polymerase Inhibitors (Pharmacologic Class)
Foscarnet (Compound) causes Blood urea increased (Side Effect)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Foscarnet may lead to a major life threatening interaction when taken with Iohexol
Foscarnet may lead to a major life threatening interaction when taken with Anagrelide