DDInter362 DDInter1960
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orphenadrine
Chlorpheniramine {u} (Compound) resembles {v} (Compound) Chloropyramine
Chlorpheniramine {u} (Compound) resembles {v} (Compound) Pheniramine
Chlorpheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Chlorpheniramine {u} (Compound) binds {v} (Gene) CYP2D6
Chlorpheniramine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Chlorpheniramine {u} (Compound) downregulates {v} (Gene) AKR1B10
Chlorpheniramine {u} (Compound) causes {v} (Side Effect) Drowsiness
Chlorpheniramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Chlorpheniramine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine
Chlorpheniramine (Compound) resembles Chloropyramine (Compound)
Chlorpheniramine (Compound) resembles Pheniramine (Compound)
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Chlorpheniramine (Compound) binds CYP2D6 (Gene)
Chlorpheniramine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Chlorpheniramine (Compound) downregulates AKR1B10 (Gene)
Chlorpheniramine (Compound) causes Drowsiness (Side Effect)
Chlorpheniramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Chlorpheniramine may lead to a major life threatening interaction when taken with Dextropropoxyphene