DDInter1042 DDInter78
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Amitriptyline {u} (Compound) resembles {v} (Compound) Pheniramine
Amitriptyline {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Amitriptyline {u} (Compound) treats {v} (Disease) migraine
Amitriptyline {u} (Compound) binds {v} (Gene) KCNQ2
Amitriptyline {u} (Compound) upregulates {v} (Gene) PPP1R13B
Amitriptyline {u} (Compound) palliates {v} (Disease) multiple sclerosis
Amitriptyline {u} (Compound) downregulates {v} (Gene) NUP85
Amitriptyline {u} (Compound) causes {v} (Side Effect) Tinnitus
Amitriptyline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Amitriptyline (Compound) resembles Pheniramine (Compound)
Amitriptyline (Compound) resembles Bromodiphenhydramine (Compound)
Amitriptyline (Compound) treats migraine (Disease)
Amitriptyline (Compound) binds KCNQ2 (Gene)
Amitriptyline (Compound) upregulates PPP1R13B (Gene)
Amitriptyline (Compound) palliates multiple sclerosis (Disease)
Amitriptyline (Compound) downregulates NUP85 (Gene)
Amitriptyline (Compound) causes Tinnitus (Side Effect)
Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole