DDInter917 DDInter1676
A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Indinavir {u} (Compound) resembles {v} (Compound) Alvimopan
Indinavir {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
Indinavir {u} (Compound) binds {v} (Gene) CYP2D6
Indinavir {u} (Compound) upregulates {v} (Gene) SSBP2
Indinavir {u} (Compound) downregulates {v} (Gene) MIF
Indinavir {u} (Compound) causes {v} (Side Effect) Body temperature increased
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Medroxyprogesterone acetate
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Indinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Indinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Indinavir (Compound) resembles Alvimopan (Compound)
Indinavir (Compound) treats acquired immunodeficiency syndrome (Disease)
Indinavir (Compound) binds CYP2D6 (Gene)
Indinavir (Compound) upregulates SSBP2 (Gene)
Indinavir (Compound) downregulates MIF (Gene)
Indinavir (Compound) causes Body temperature increased (Side Effect)
Indinavir may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesterone acetate
Indinavir may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin