DDInter1938 DDInter576
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Vincristine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Vincristine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) downregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) downregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) upregulates {v} (Gene) PSMD9
PSMD9 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Vincristine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Vincristine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) regulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Vincristine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Vincristine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Vincristine (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Vincristine (Compound) binds TUBB6 (Gene) and Vincristine (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is upregulated by Disulfiram (Compound)
Vincristine (Compound) downregulates DDB2 (Gene) and DDB2 (Gene) is downregulated by Disulfiram (Compound)
Vincristine (Compound) upregulates PSMD9 (Gene) and PSMD9 (Gene) is downregulated by Disulfiram (Compound)
Vincristine (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Disulfiram (Compound)
Vincristine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Vincristine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)
Vincristine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) regulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Disulfiram (Compound)