DDInter1305 DDInter569
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed for use within many non-prescription over-the-counter sleep aids and cough-and-cold medications that have been marketed for "night time" use [L5263, L5281, L5287]. Diphenhydramine is also used in combination with as the anti-nausea drug where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system . Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid . As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) GUCY1A2
GUCY1A2 {u} (Gene) is bound by {v} (Compound) Nitroglycerin
Nitroglycerin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Cinnarizine
Cinnarizine {u} (Compound) resembles {v} (Compound) Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) NPR1
NPR1 {u} (Gene) is bound by {v} (Compound) Amyl Nitrite
Amyl Nitrite {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) GUCY1B3
GUCY1B3 {u} (Gene) is downregulated by {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Tamoxifen
Tamoxifen {u} may lead to a major life threatening interaction when taken with {v} Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is associated with {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Amitriptyline
Amitriptyline {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Diphenhydramine (Compound)
Nitroprusside (Compound) binds GUCY1A2 (Gene) and GUCY1A2 (Gene) is bound by Nitroglycerin (Compound) and Nitroglycerin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Toremifene (Compound) and Toremifene (Compound) resembles Diphenhydramine (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cinnarizine (Compound) and Cinnarizine (Compound) resembles Diphenhydramine (Compound)
Nitroprusside (Compound) binds NPR1 (Gene) and NPR1 (Gene) is bound by Amyl Nitrite (Compound) and Amyl Nitrite may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Nitroprusside (Compound) binds GUCY1B3 (Gene) and GUCY1B3 (Gene) is downregulated by Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Diphenhydramine (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Tamoxifen (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Diphenhydramine
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is associated with schizophrenia (Disease) and schizophrenia (Disease) is palliated by Diphenhydramine (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amitriptyline (Compound) and Amitriptyline (Compound) resembles Diphenhydramine (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Doxepin (Compound) and Doxepin (Compound) resembles Diphenhydramine (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine