DDInter825 DDInter1845
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive β cell failure and long-term microvascular and macrovascular complications that lead to co-morbidities and mortalities. Sulfonylureas are one of the insulin secretagogues widely used for the management of type 2 diabetes to lower blood glucose levels. The main effect of SUs is thought to be effective when residual pancreatic β-cells are present, as they work by stimulating the release of insulin from the pancreatic beta cells and they are also thought to exert extra-pancreatic effects, such as increasing the insulin-mediated peripheral glucose uptake. Glimepiride works by stimulating the secretion of insulin granules from
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phendimetrazine
Phendimetrazine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Tranylcypromine
Glimepiride {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Tranylcypromine
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phendimetrazine
Phendimetrazine {u} may lead to a major life threatening interaction when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine (Compound) resembles Tranylcypromine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phendimetrazine and Phendimetrazine (Compound) resembles Tranylcypromine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Tranylcypromine (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Tranylcypromine (Compound)
Glimepiride (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Tranylcypromine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Tranylcypromine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Phendimetrazine and Phendimetrazine may lead to a major life threatening interaction when taken with Phentermine and Phentermine (Compound) resembles Tranylcypromine (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)
Glimepiride (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)
Glimepiride (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Tranylcypromine (Compound)