DDInter1244 DDInter1305
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitroglycerin
Nitroglycerin {u} (Compound) binds {v} (Gene) GUCY1A2
GUCY1A2 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Morphine {u} (Compound) palliates {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is associated with {v} (Gene) GUCY1A3
GUCY1A3 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Galantamine {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Nitroprusside
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ephedrine
Ephedrine {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) is bound by {v} (Compound) Nitroprusside
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvoxamine
Fluvoxamine {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Morphine {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Clozapine {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Nitroprusside
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Nitroglycerin and Nitroglycerin (Compound) binds GUCY1A2 (Gene) and GUCY1A2 (Gene) is bound by Nitroprusside (Compound)
Morphine (Compound) palliates coronary artery disease (Disease) and coronary artery disease (Disease) is associated with GUCY1A3 (Gene) and GUCY1A3 (Gene) is bound by Nitroprusside (Compound)
Morphine (Compound) resembles Galantamine (Compound) and Galantamine (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Nitroprusside (Compound)
Morphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine and Ephedrine (Compound) binds ACHE (Gene) and ACHE (Gene) is bound by Nitroprusside (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)
Morphine may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Nitroprusside (Compound)