DDInter1876 DDInter1376
Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Trimipramine {u} (Compound) resembles {v} (Compound) Clomipramine
Trimipramine {u} (Compound) binds {v} (Gene) CYP2C9
Trimipramine {u} (Compound) upregulates {v} (Gene) SUV39H1
Trimipramine {u} (Compound) downregulates {v} (Gene) CCDC86
Trimipramine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Trimipramine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ammonium chloride
Trimipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sorafenib
Trimipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Trimipramine {u} may lead to a major life threatening interaction when taken with {v} Osimertinib
Trimipramine {u} may lead to a major life threatening interaction when taken with {v} Palonosetron
Trimipramine (Compound) resembles Clomipramine (Compound)
Trimipramine (Compound) binds CYP2C9 (Gene)
Trimipramine (Compound) upregulates SUV39H1 (Gene)
Trimipramine (Compound) downregulates CCDC86 (Gene)
Trimipramine (Compound) causes Diarrhoea (Side Effect)
Trimipramine may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Trimipramine may lead to a major life threatening interaction when taken with Osimertinib
Trimipramine may lead to a major life threatening interaction when taken with Palonosetron