DDInter687 DDInter458
Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids. It is used to treat or manage a variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA).
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Etanercept {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Vitamin E {u} (Compound) binds {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestimate
Norgestimate {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Cyclosporine
Etanercept {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Vitamin E {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Ethionamide {u} (Compound) upregulates {v} (Gene) CNPY3
CNPY3 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethambutol
Ethambutol {u} (Compound) causes {v} (Side Effect) Visual impairment
Visual impairment {u} (Side Effect) is caused by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Ethionamide {u} (Compound) downregulates {v} (Gene) ZDHHC6
ZDHHC6 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestimate
Norgestimate {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Stavudine
Stavudine {u} (Compound) upregulates {v} (Gene) CDK5R1
CDK5R1 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Lidocaine {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Cyclosporine
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E (Compound) binds HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Norgestimate and Norgestimate (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Cyclosporine (Compound)
Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol and Ethambutol (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide (Compound) downregulates ZDHHC6 (Gene) and ZDHHC6 (Gene) is downregulated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Norgestimate and Norgestimate (Compound) downregulates MYC (Gene) and MYC (Gene) is upregulated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Stavudine and Stavudine (Compound) upregulates CDK5R1 (Gene) and CDK5R1 (Gene) is downregulated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine (Compound) palliates rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Cyclosporine (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds PNP (Gene) and PNP (Gene) is downregulated by Cyclosporine (Compound)