DDInter569 DDInter396
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed
Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Clevidipine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clevidipine
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Clevidipine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Nitrendipine
Nitrendipine {u} (Compound) resembles {v} (Compound) Clevidipine
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Nifedipine {u} (Compound) resembles {v} (Compound) Clevidipine
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) binds {v} (Gene) CACNA1C
CACNA1C {u} (Gene) is bound by {v} (Compound) Clevidipine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Calcium Channel Antagonists {u} (Pharmacologic Class) includes {v} (Compound) Clevidipine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nimodipine
Nimodipine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Clevidipine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thiethylperazine
Thiethylperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Clevidipine (Compound)
Diphenhydramine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clevidipine (Compound)
Diphenhydramine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Clevidipine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Nitrendipine (Compound) and Nitrendipine (Compound) resembles Clevidipine (Compound)
Diphenhydramine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound) and Nifedipine (Compound) resembles Clevidipine (Compound)
Diphenhydramine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Nicardipine (Compound) and Nicardipine (Compound) resembles Clevidipine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) binds CACNA1C (Gene) and CACNA1C (Gene) is bound by Clevidipine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class) and Calcium Channel Antagonists (Pharmacologic Class) includes Clevidipine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Clevidipine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Clevidipine (Compound)