DDInter1440 DDInter576
Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name of Nardil.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Phenelzine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) downregulates {v} (Gene) TRIB1
TRIB1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) downregulates {v} (Gene) TRIB1
TRIB1 {u} (Gene) regulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is regulated by {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Phenelzine {u} (Compound) resembles {v} (Compound) Selegiline
Selegiline {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Disulfiram
Phenelzine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Phenelzine (Compound) downregulates TRIB1 (Gene) and TRIB1 (Gene) is upregulated by Disulfiram (Compound)
Phenelzine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Disulfiram (Compound)
Phenelzine (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Disulfiram (Compound)
Phenelzine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Phenelzine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Phenelzine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)
Phenelzine (Compound) downregulates TRIB1 (Gene) and TRIB1 (Gene) regulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Disulfiram (Compound)
Phenelzine (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is regulated by NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Phenelzine (Compound) resembles Selegiline (Compound) and Selegiline (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Disulfiram (Compound)