DDInter504 DDInter1180
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Desipramine {u} (Compound) resembles {v} (Compound) Aprindine
Desipramine {u} (Compound) resembles {v} (Compound) Protriptyline
Desipramine {u} (Compound) binds {v} (Gene) SLC22A2
Desipramine {u} (Compound) upregulates {v} (Gene) ALDOC
Desipramine {u} (Compound) palliates {v} (Disease) attention deficit hyperactivity disorder
Desipramine {u} (Compound) downregulates {v} (Gene) HAT1
Desipramine {u} (Compound) causes {v} (Side Effect) Disturbance in sexual arousal
Desipramine (Compound) resembles Aprindine (Compound)
Desipramine (Compound) resembles Protriptyline (Compound)
Desipramine (Compound) binds SLC22A2 (Gene)
Desipramine (Compound) upregulates ALDOC (Gene)
Desipramine (Compound) palliates attention deficit hyperactivity disorder (Disease)
Desipramine (Compound) downregulates HAT1 (Gene)
Desipramine (Compound) causes Disturbance in sexual arousal (Side Effect)