DDInter1729 DDInter744
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
A fluorinated cytosine analog that is used as an antifungal agent.
Sulindac {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Flucytosine
Sulindac {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Pentamidine
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flucytosine
Sulindac {u} (Compound) causes {v} (Side Effect) Gastrointestinal haemorrhage
Gastrointestinal haemorrhage {u} (Side Effect) is caused by {v} (Compound) Radium Ra 223 dichloride
Radium Ra 223 dichloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Methoxyflurane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) DNMT1
DNMT1 {u} (Gene) is bound by {v} (Compound) Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) regulates {v} (Gene) CCDC85B
CCDC85B {u} (Gene) is downregulated by {v} (Compound) Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) GRWD1
GRWD1 {u} (Gene) is downregulated by {v} (Compound) Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Cytarabine
Cytarabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Flucytosine
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Flucytosine
Sulindac (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Sulindac (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Pentamidine (Compound) and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine
Sulindac (Compound) causes Gastrointestinal haemorrhage (Side Effect) and Gastrointestinal haemorrhage (Side Effect) is caused by Radium Ra 223 dichloride (Compound) and Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Methoxyflurane (Compound) and Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by DNMT1 (Gene) and DNMT1 (Gene) is bound by Flucytosine (Compound)
Sulindac (Compound) binds AKR1B1 (Gene) and AKR1B1 (Gene) regulates CCDC85B (Gene) and CCDC85B (Gene) is downregulated by Flucytosine (Compound)
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by GRWD1 (Gene) and GRWD1 (Gene) is downregulated by Flucytosine (Compound)
Sulindac (Compound) binds AKR1B1 (Gene) and AKR1B1 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Flucytosine (Compound)
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Cytarabine (Compound) and Cytarabine may cause a minor interaction that can limit clinical effects when taken with Flucytosine
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clozapine (Compound) and Clozapine may lead to a major life threatening interaction when taken with Flucytosine