DDInter1312 DDInter1544
Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol]. Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency, and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.[L9527,L10301,L10304,L10307] First derived in 1951 in Mexico City, norethisterone was originally intended for use as a remedy for irregular menstruation and endometriosis, and was not marketed for use as an oral contraceptive until 1962.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Norethisterone {u} (Compound) resembles {v} (Compound) Mestranol
Norethisterone {u} (Compound) resembles {v} (Compound) Cortisone acetate
Norethisterone {u} (Compound) binds {v} (Gene) ALB
Norethisterone {u} (Compound) upregulates {v} (Gene) PGM3
Norethisterone {u} (Compound) palliates {v} (Disease) polycystic ovary syndrome
Norethisterone {u} (Compound) is included by {v} (Pharmacologic Class) Progesterone Congeners
Norethisterone {u} (Compound) downregulates {v} (Gene) PAICS
Norethisterone {u} (Compound) causes {v} (Side Effect) Depression
Norethisterone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pioglitazone
Norethisterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Norethisterone (Compound) resembles Mestranol (Compound)
Norethisterone (Compound) resembles Cortisone acetate (Compound)
Norethisterone (Compound) binds ALB (Gene)
Norethisterone (Compound) upregulates PGM3 (Gene)
Norethisterone (Compound) palliates polycystic ovary syndrome (Disease)
Norethisterone (Compound) is included by Progesterone Congeners (Pharmacologic Class)
Norethisterone (Compound) downregulates PAICS (Gene)
Norethisterone (Compound) causes Depression (Side Effect)
Norethisterone may cause a minor interaction that can limit clinical effects when taken with Pioglitazone
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib