DDInter459 DDInter1397
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Cyproheptadine {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) upregulates {v} (Gene) GRWD1
GRWD1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is associated with {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) binds {v} (Gene) CHRM1
CHRM1 {u} (Gene) regulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is regulated by {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cyproheptadine {u} (Compound) downregulates {v} (Gene) GRN
GRN {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Cyproheptadine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Paroxetine (Compound)
Cyproheptadine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Paroxetine (Compound)
Cyproheptadine (Compound) downregulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Cyproheptadine (Compound) upregulates GRWD1 (Gene) and GRWD1 (Gene) is downregulated by Paroxetine (Compound)
Cyproheptadine (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Paroxetine (Compound)
Cyproheptadine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Paroxetine (Compound)
Cyproheptadine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is associated with panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)
Cyproheptadine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) regulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Cyproheptadine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is regulated by GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Cyproheptadine (Compound) downregulates GRN (Gene) and GRN (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Paroxetine (Compound)