DDInter112 DDInter1853
Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Aprepitant {u} (Compound) resembles {v} (Compound) Fosaprepitant
Fosaprepitant {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Stevens-Johnson syndrome {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Alitretinoin
Alitretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Aprepitant {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) GFOD1
GFOD1 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) palliates {v} (Disease) breast cancer
breast cancer {u} (Disease) downregulates {v} (Gene) ARID5B
ARID5B {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Aprepitant {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) upregulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tretinoin
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Tretinoin (Compound)
Aprepitant (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Tretinoin (Compound)
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tretinoin (Compound)
Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Aprepitant (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Aprepitant (Compound) resembles Fosaprepitant (Compound) and Fosaprepitant (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Tretinoin (Compound)
Aprepitant (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Alitretinoin (Compound) and Alitretinoin (Compound) resembles Tretinoin (Compound)
Aprepitant (Compound) palliates colon cancer (Disease) and colon cancer (Disease) downregulates GFOD1 (Gene) and GFOD1 (Gene) is upregulated by Tretinoin (Compound)
Aprepitant (Compound) palliates breast cancer (Disease) and breast cancer (Disease) downregulates ARID5B (Gene) and ARID5B (Gene) is downregulated by Tretinoin (Compound)
Aprepitant (Compound) palliates colon cancer (Disease) and colon cancer (Disease) upregulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tretinoin (Compound)