DDInter742 DDInter255
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Floxuridine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Busulfan
Floxuridine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) regulates {v} (Gene) MAMLD1
MAMLD1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Floxuridine {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is associated with {v} (Disease) and {u} (Gene) is upregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Floxuridine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Floxuridine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Floxuridine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Busulfan (Compound)
Floxuridine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Busulfan (Compound)
Floxuridine (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Busulfan (Compound)
Floxuridine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) regulates MAMLD1 (Gene) and MAMLD1 (Gene) is upregulated by Busulfan (Compound)
Floxuridine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Floxuridine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Floxuridine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)
Floxuridine (Compound) downregulates MYC (Gene) and MYC (Gene) is associated with hematologic cancer (Disease) and MYC (Gene) is upregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Floxuridine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)