DDInter917 DDInter1694
A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval of the medication is supported by data from three double-blind, placebo-controlled trials and two open-label trials which showed that the onset of action was approximately 1.0 hour and the median time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving normal potassium levels within 48 hours following administration. The treatment effect was maintained for up to 12 months.
Indinavir {u} (Compound) resembles {v} (Compound) Alvimopan
Indinavir {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
Indinavir {u} (Compound) binds {v} (Gene) CYP2D6
Indinavir {u} (Compound) upregulates {v} (Gene) SSBP2
Indinavir {u} (Compound) downregulates {v} (Gene) MIF
Indinavir {u} (Compound) causes {v} (Side Effect) Body temperature increased
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Medroxyprogesterone acetate
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Indinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Indinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Indinavir (Compound) resembles Alvimopan (Compound)
Indinavir (Compound) treats acquired immunodeficiency syndrome (Disease)
Indinavir (Compound) binds CYP2D6 (Gene)
Indinavir (Compound) upregulates SSBP2 (Gene)
Indinavir (Compound) downregulates MIF (Gene)
Indinavir (Compound) causes Body temperature increased (Side Effect)
Indinavir may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesterone acetate
Indinavir may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin