DDInter458 DDInter485
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) CSK
CSK {u} (Gene) is downregulated by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is downregulated by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) EPCAM
EPCAM {u} (Gene) is upregulated by {v} (Compound) Daunorubicin
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Daunorubicin (Compound)
Cyclosporine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Daunorubicin (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Daunorubicin (Compound)
Cyclosporine (Compound) downregulates CSK (Gene) and CSK (Gene) is downregulated by Daunorubicin (Compound)
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Daunorubicin (Compound)
Cyclosporine (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Daunorubicin (Compound)
Cyclosporine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Daunorubicin (Compound) and TOP2A (Gene) is downregulated by Daunorubicin (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Daunorubicin (Compound)
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates EPCAM (Gene) and EPCAM (Gene) is upregulated by Daunorubicin (Compound)
Cyclosporine (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is bound by Doxorubicin (Compound) and ABCC10 (Gene) is upregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Daunorubicin (Compound)