DDInter1570 DDInter1936
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Ranolazine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vinblastine
Ranolazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Ranolazine {u} (Compound) downregulates {v} (Gene) TPI1
TPI1 {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Ranolazine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Vinblastine
Ranolazine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vindesine
Vindesine {u} (Compound) resembles {v} (Compound) Vinblastine
Ranolazine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Ranolazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) regulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is upregulated by {v} (Compound) Vinblastine
Ranolazine {u} (Compound) downregulates {v} (Gene) TPI1
TPI1 {u} (Gene) is downregulated by {v} (Compound) Vindesine
Vindesine {u} (Compound) resembles {v} (Compound) Vinblastine
Ranolazine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Vincristine
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Ranolazine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinblastine
Ranolazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinblastine (Compound)
Ranolazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Vinblastine (Compound)
Ranolazine (Compound) downregulates TPI1 (Gene) and TPI1 (Gene) is downregulated by Vinblastine (Compound)
Ranolazine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Vinblastine (Compound)
Ranolazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vindesine (Compound) and Vindesine (Compound) resembles Vinblastine (Compound)
Ranolazine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Ranolazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) regulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Vinblastine (Compound)
Ranolazine (Compound) downregulates TPI1 (Gene) and TPI1 (Gene) is downregulated by Vindesine (Compound) and Vindesine (Compound) resembles Vinblastine (Compound)
Ranolazine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Vincristine (Compound) and Vincristine (Compound) resembles Vinblastine (Compound)
Ranolazine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine