DDInter1069 DDInter832
Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from _Escherichia coli_, the first natural ligand that activates GC-C. Linaclotide is used for the treatment of various types of constipation, including irritable bowel syndrome with constipation. Linaclotide was first approved by the FDA on August 30, 2012. It gained EMA and Health Canada approval on November 26, 2012 and December 3, 2013, respectively. Linaclotide works to improve the symptoms of constipation and gastrointestinal symptoms of conditions involving constipation
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Linaclotide {u} (Compound) resembles {v} (Compound) Carbetocin
Linaclotide {u} (Compound) resembles {v} (Compound) Vapreotide
Linaclotide {u} (Compound) binds {v} (Gene) GUCY2C
Linaclotide {u} (Compound) is included by {v} (Pharmacologic Class) Guanylate Cyclase Activators
Linaclotide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Etodolac
Linaclotide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methylcellulose
Linaclotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestrel
Linaclotide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levonorgestrel
Linaclotide (Compound) resembles Carbetocin (Compound)
Linaclotide (Compound) resembles Vapreotide (Compound)
Linaclotide (Compound) binds GUCY2C (Gene)
Linaclotide (Compound) is included by Guanylate Cyclase Activators (Pharmacologic Class)
Linaclotide may cause a minor interaction that can limit clinical effects when taken with Etodolac
Linaclotide may cause a minor interaction that can limit clinical effects when taken with Methylcellulose
Linaclotide may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Linaclotide may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel