DDInter604 DDInter1652
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thrombo
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Drospirenone {u} (Compound) resembles {v} (Compound) Flurandrenolide
Drospirenone {u} (Compound) resembles {v} (Compound) Progesterone
Drospirenone {u} (Compound) binds {v} (Gene) PTGS2
Drospirenone {u} (Compound) palliates {v} (Disease) polycystic ovary syndrome
Drospirenone {u} (Compound) is included by {v} (Pharmacologic Class) Progesterone Congeners
Drospirenone {u} (Compound) causes {v} (Side Effect) Uterine haemorrhage
Drospirenone (Compound) resembles Flurandrenolide (Compound)
Drospirenone (Compound) resembles Progesterone (Compound)
Drospirenone (Compound) binds PTGS2 (Gene)
Drospirenone (Compound) palliates polycystic ovary syndrome (Disease)
Drospirenone (Compound) is included by Progesterone Congeners (Pharmacologic Class)
Drospirenone (Compound) causes Uterine haemorrhage (Side Effect)