DDInter537 DDInter698
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin]. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Etidronic acid
Diclofenac {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) regulates {v} (Gene) DHX29
DHX29 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Diclofenac {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Risedronic acid and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Etidronic acid (Compound)
Diclofenac (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Etidronic acid (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Risedronic acid and Risedronic acid (Compound) resembles Ibandronate (Compound) and Ibandronate (Compound) resembles Etidronic acid (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid and Pamidronic acid (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Diclofenac (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) regulates DHX29 (Gene) and DHX29 (Gene) is upregulated by Etidronic acid (Compound)
Diclofenac (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Diclofenac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)