DDInter1707 DDInter957
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Spironolactone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Spironolactone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Irinotecan {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Irinotecan {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Tetracycline {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Spironolactone {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Spironolactone {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Spironolactone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Spironolactone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Diatrizoate (Compound) and Diatrizoate (Compound) resembles Iodipamide (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Spironolactone (Compound) resembles Testosterone (Compound) and Testosterone (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Spironolactone (Compound) resembles Testosterone (Compound) and Testosterone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)
Spironolactone (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Spironolactone (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)