DDInter948 DDInter1472
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in vivo_ with little consequence. The thiazolidinedione class of medications, which also includes [rosiglitazone] and [troglitazone], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ). PPARs are ligand-activated transcription factors that are involved in the expression of more than 100 genes and affect numerous metabolic processes, most notably lipid and glucose homeostasis. Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart failure, bladder cancer) and the availability of safer and more effective alternatives for patients with type 2 diabetes mellitus.
Pioglitazone {u} (Compound) resembles {v} (Compound) Rosiglitazone
Pioglitazone {u} (Compound) treats {v} (Disease) type 2 diabetes mellitus
Pioglitazone {u} (Compound) binds {v} (Gene) CYP2D6
Pioglitazone {u} (Compound) upregulates {v} (Gene) GPC1
Pioglitazone {u} (Compound) is included by {v} (Pharmacologic Class) Thiazolidinediones
Pioglitazone {u} (Compound) downregulates {v} (Gene) RGS2
Pioglitazone {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lipoic acid
Pioglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Pioglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Remdesivir
Pioglitazone (Compound) resembles Rosiglitazone (Compound)
Pioglitazone (Compound) treats type 2 diabetes mellitus (Disease)
Pioglitazone (Compound) binds CYP2D6 (Gene)
Pioglitazone (Compound) upregulates GPC1 (Gene)
Pioglitazone (Compound) is included by Thiazolidinediones (Pharmacologic Class)
Pioglitazone (Compound) downregulates RGS2 (Gene)
Pioglitazone (Compound) causes Acute coronary syndrome (Side Effect)
Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Lipoic acid
Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir