DDInter551 DDInter856
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Diflunisal {u} (Compound) resembles {v} (Compound) Salsalate
Diflunisal {u} (Compound) resembles {v} (Compound) Salicylic acid
Diflunisal {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Diflunisal {u} (Compound) binds {v} (Gene) PTGS2
Diflunisal {u} (Compound) upregulates {v} (Gene) HLA-DMA
Diflunisal {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
Diflunisal {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Diflunisal {u} (Compound) downregulates {v} (Gene) EPN2
Diflunisal {u} (Compound) causes {v} (Side Effect) Photosensitivity reaction
Diflunisal {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Diflunisal (Compound) resembles Salsalate (Compound)
Diflunisal (Compound) resembles Salicylic acid (Compound)
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Diflunisal (Compound) binds PTGS2 (Gene)
Diflunisal (Compound) upregulates HLA-DMA (Gene)
Diflunisal (Compound) palliates rheumatoid arthritis (Disease)
Diflunisal (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Diflunisal (Compound) downregulates EPN2 (Gene)
Diflunisal (Compound) causes Photosensitivity reaction (Side Effect)
Diflunisal may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase