DDInter1859 DDInter957
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on the distal nephron where only a small fraction of sodium ion reabsorption occurs, triamterene is reported to have limited diuretic efficacy. Due to its effects on increased serum potassium levels, triamterene is associated with a risk of producing hyperkalemia. Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. Triamterene was approved by the Food and Drug Administration in the U.S. in 1964. Currently, triamterene is used in the treatment of edema associated with various
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Triamterene {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Triamterene {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Irinotecan {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Irinotecan {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Triamterene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetracycline
Tetracycline {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Triamterene {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Triamterene {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iohexol
Iohexol {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iodipamide
Triamterene {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Iodipamide
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iohexol
Iohexol {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Iodipamide
Triamterene (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)
Triamterene (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Diatrizoate (Compound) and Diatrizoate (Compound) resembles Iodipamide (Compound)
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Triamterene may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Triamterene (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Triamterene (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iodipamide (Compound)
Triamterene (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by NVL (Gene) and NVL (Gene) is downregulated by Iodipamide (Compound)
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Iodipamide (Compound)