DDInter1086 DDInter178
An alkylating agent of value against both hematologic malignancies and solid tumors.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Lomustine {u} (Compound) treats {v} (Disease) brain cancer
Lomustine {u} (Compound) binds {v} (Gene) CYP3A4
Lomustine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Lomustine {u} (Compound) causes {v} (Side Effect) Visual impairment
Lomustine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Lomustine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Delafloxacin
Lomustine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Filgrastim
Lomustine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Radium Ra 223 dichloride
Lomustine {u} may lead to a major life threatening interaction when taken with {v} Lomitapide
Lomustine {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Lomustine (Compound) treats brain cancer (Disease)
Lomustine (Compound) binds CYP3A4 (Gene)
Lomustine (Compound) is included by Alkylating Activity (Pharmacologic Class)
Lomustine (Compound) causes Visual impairment (Side Effect)
Lomustine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin
Lomustine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim
Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Lomustine may lead to a major life threatening interaction when taken with Lomitapide
Lomustine may lead to a major life threatening interaction when taken with Clozapine