DDInter885 DDInter1376
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone was granted FDA approval on 5 August 1952.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Hydrocortisone {u} (Compound) resembles {v} (Compound) Loteprednol
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eplerenone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Fludrocortisone
Hydrocortisone {u} (Compound) treats {v} (Disease) gout
Hydrocortisone {u} (Compound) binds {v} (Gene) CYP11B1
Hydrocortisone {u} (Compound) upregulates {v} (Gene) PRKCD
Hydrocortisone {u} (Compound) palliates {v} (Disease) prostate cancer
Hydrocortisone {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Hydrocortisone {u} (Compound) downregulates {v} (Gene) AMIGO2
Hydrocortisone {u} (Compound) causes {v} (Side Effect) Papilloedema
Hydrocortisone (Compound) resembles Loteprednol (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone
Hydrocortisone (Compound) resembles Fludrocortisone (Compound)
Hydrocortisone (Compound) treats gout (Disease)
Hydrocortisone (Compound) binds CYP11B1 (Gene)
Hydrocortisone (Compound) upregulates PRKCD (Gene)
Hydrocortisone (Compound) palliates prostate cancer (Disease)
Hydrocortisone (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Hydrocortisone (Compound) downregulates AMIGO2 (Gene)
Hydrocortisone (Compound) causes Papilloedema (Side Effect)