DDInter350 DDInter1174
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) upregulates {v} (Gene) LRP10
LRP10 {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Chlorambucil {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) resembles {v} (Disease) bone cancer
bone cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) resembles {v} (Disease) muscle cancer
muscle cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Chlorambucil {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Prednisolone
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Chlorambucil {u} (Compound) upregulates {v} (Gene) LRP10
LRP10 {u} (Gene) is downregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Methotrexate (Compound)
Chlorambucil (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Methotrexate (Compound)
Chlorambucil (Compound) upregulates LRP10 (Gene) and LRP10 (Gene) is upregulated by Methotrexate (Compound)
Chlorambucil (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Methotrexate (Compound)
Chlorambucil (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Chlorambucil (Compound) treats breast cancer (Disease) and breast cancer (Disease) resembles bone cancer (Disease) and bone cancer (Disease) is treated by Methotrexate (Compound)
Chlorambucil (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) resembles muscle cancer (Disease) and muscle cancer (Disease) is treated by Methotrexate (Compound)
Chlorambucil (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate
Chlorambucil (Compound) upregulates LRP10 (Gene) and LRP10 (Gene) is downregulated by colon cancer (Disease) and colon cancer (Disease) is treated by Methotrexate (Compound)