DDInter1520 DDInter178
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Primaquine {u} (Compound) resembles {v} (Compound) Chloroquine
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Primaquine {u} (Compound) binds {v} (Gene) SENP8
Primaquine {u} (Compound) downregulates {v} (Gene) PSMB8
Primaquine {u} (Compound) causes {v} (Side Effect) Nausea
Primaquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Romidepsin
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Primaquine (Compound) resembles Chloroquine (Compound)
Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Primaquine (Compound) binds SENP8 (Gene)
Primaquine (Compound) downregulates PSMB8 (Gene)
Primaquine (Compound) causes Nausea (Side Effect)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Primaquine may lead to a major life threatening interaction when taken with Prilocaine