DDInter1550 DDInter1639
One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Pyrimethamine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) regulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) PAH
PAH {u} (Gene) is bound by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) downregulates {v} (Gene) NOSIP
NOSIP {u} (Gene) interacts with {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) regulates {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) upregulates {v} (Gene) TCEAL4
TCEAL4 {u} (Gene) is regulated by {v} (Gene) PAH
PAH {u} (Gene) is bound by {v} (Compound) Sapropterin
Pyrimethamine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Sapropterin
Pyrimethamine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sapropterin (Compound)
Pyrimethamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sapropterin (Compound)
Pyrimethamine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sapropterin (Compound)
Pyrimethamine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) regulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sapropterin (Compound)
Pyrimethamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by PAH (Gene) and PAH (Gene) is bound by Sapropterin (Compound)
Pyrimethamine (Compound) downregulates NOSIP (Gene) and NOSIP (Gene) interacts with NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)
Pyrimethamine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) regulates NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)
Pyrimethamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Sapropterin (Compound)
Pyrimethamine (Compound) upregulates TCEAL4 (Gene) and TCEAL4 (Gene) is regulated by PAH (Gene) and PAH (Gene) is bound by Sapropterin (Compound)
Pyrimethamine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Sapropterin (Compound)