DDInter246 DDInter131
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted FDA approval on 18 October 2016. In November 2022, the manufacturer (Genentech) voluntarily withdrew the use of atezolizumab for the treatment of urothelial carcinoma, previously approved under the FDA's Accelerated Approval Program. The rest of atezolizumab indications remain unaffected.
Budesonide {u} (Compound) resembles {v} (Compound) Flurandrenolide
Budesonide {u} (Compound) treats {v} (Disease) asthma
Budesonide {u} (Compound) binds {v} (Gene) CYP3A4
Budesonide {u} (Compound) upregulates {v} (Gene) P4HA2
Budesonide {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Budesonide {u} (Compound) downregulates {v} (Gene) RAP1GAP
Budesonide {u} (Compound) causes {v} (Side Effect) Pain
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Isoprenaline
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipilimumab
Budesonide (Compound) resembles Flurandrenolide (Compound)
Budesonide (Compound) treats asthma (Disease)
Budesonide (Compound) binds CYP3A4 (Gene)
Budesonide (Compound) upregulates P4HA2 (Gene)
Budesonide (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Budesonide (Compound) downregulates RAP1GAP (Gene)
Budesonide (Compound) causes Pain (Side Effect)
Budesonide may cause a minor interaction that can limit clinical effects when taken with Isoprenaline
Budesonide may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab