DDInter658 DDInter704
Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Eprosartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Eprosartan {u} (Compound) downregulates {v} (Gene) KRT18
KRT18 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Eprosartan {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Everolimus
Eprosartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Eprosartan {u} (Compound) downregulates {v} (Gene) KRT18
KRT18 {u} (Gene) is regulated by {v} (Gene) BTG1
BTG1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Eprosartan {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Eprosartan {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Eprosartan {u} (Compound) resembles {v} (Compound) Losartan
Losartan {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Eprosartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Temsirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Eprosartan {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) downregulates {v} (Gene) TMEM97
TMEM97 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Eprosartan (Compound) downregulates KRT18 (Gene) and KRT18 (Gene) is downregulated by Everolimus (Compound)
Eprosartan (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Everolimus (Compound)
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Eprosartan (Compound) downregulates KRT18 (Gene) and KRT18 (Gene) is regulated by BTG1 (Gene) and BTG1 (Gene) is upregulated by Everolimus (Compound)
Eprosartan (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Eprosartan (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Eprosartan (Compound) resembles Losartan (Compound) and Losartan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound)
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound) and Temsirolimus (Compound) resembles Everolimus (Compound)
Eprosartan (Compound) treats hypertension (Disease) and hypertension (Disease) downregulates TMEM97 (Gene) and TMEM97 (Gene) is downregulated by Everolimus (Compound)