DDInter458 DDInter150
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) downregulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) upregulates {v} (Gene) INTS3
INTS3 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hodgkin's disease
Hodgkin's disease {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) resembles {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) resembles {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) downregulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is regulated by {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Cyclosporine {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Azathioprine
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Cyclosporine (Compound) downregulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Cyclosporine (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Cyclosporine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Cyclosporine (Compound) upregulates INTS3 (Gene) and INTS3 (Gene) is downregulated by Azathioprine (Compound)
Cyclosporine (Compound) causes Hodgkin's disease (Side Effect) and Hodgkin's disease (Side Effect) is caused by Azathioprine (Compound)
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) resembles rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) resembles systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Cyclosporine (Compound) downregulates HPRT1 (Gene) and HPRT1 (Gene) is regulated by HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Azathioprine (Compound)
Cyclosporine (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Azathioprine (Compound)