DDInter466 DDInter178
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Dactinomycin {u} (Compound) treats {v} (Disease) germ cell cancer
Dactinomycin {u} (Compound) binds {v} (Gene) ABCB1
Dactinomycin {u} (Compound) upregulates {v} (Gene) PRR15L
Dactinomycin {u} (Compound) downregulates {v} (Gene) RNPS1
Dactinomycin {u} (Compound) causes {v} (Side Effect) Discomfort
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Gatifloxacin
Dactinomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rilonacept
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anakinra
Dactinomycin {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Dactinomycin (Compound) treats germ cell cancer (Disease)
Dactinomycin (Compound) binds ABCB1 (Gene)
Dactinomycin (Compound) upregulates PRR15L (Gene)
Dactinomycin (Compound) downregulates RNPS1 (Gene)
Dactinomycin (Compound) causes Discomfort (Side Effect)
Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Gatifloxacin
Dactinomycin may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Anakinra
Dactinomycin may lead to a major life threatening interaction when taken with Leflunomide