DDInter596 DDInter379
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reducing calcium-induced contractions.
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cilostazol
Doxorubicin {u} (Compound) downregulates {v} (Gene) EIF5
EIF5 {u} (Gene) is downregulated by {v} (Compound) Cilostazol
Doxorubicin {u} (Compound) upregulates {v} (Gene) LAP3
LAP3 {u} (Gene) is downregulated by {v} (Compound) Cilostazol
Doxorubicin {u} (Compound) causes {v} (Side Effect) Cardiac arrest
Cardiac arrest {u} (Side Effect) is caused by {v} (Compound) Cilostazol
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cilostazol
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cilostazol
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cilostazol
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Chlorpromazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cilostazol
Doxorubicin {u} (Compound) downregulates {v} (Gene) EIF5
EIF5 {u} (Gene) is regulated by {v} (Gene) CLTB
CLTB {u} (Gene) is downregulated by {v} (Compound) Cilostazol
Doxorubicin {u} (Compound) downregulates {v} (Gene) TLE1
TLE1 {u} (Gene) regulates {v} (Gene) SCAND1
SCAND1 {u} (Gene) is downregulated by {v} (Compound) Cilostazol
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Doxorubicin (Compound) downregulates EIF5 (Gene) and EIF5 (Gene) is downregulated by Cilostazol (Compound)
Doxorubicin (Compound) upregulates LAP3 (Gene) and LAP3 (Gene) is downregulated by Cilostazol (Compound)
Doxorubicin (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Cilostazol (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Chlorpromazine (Compound) and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol
Doxorubicin (Compound) downregulates EIF5 (Gene) and EIF5 (Gene) is regulated by CLTB (Gene) and CLTB (Gene) is downregulated by Cilostazol (Compound)
Doxorubicin (Compound) downregulates TLE1 (Gene) and TLE1 (Gene) regulates SCAND1 (Gene) and SCAND1 (Gene) is downregulated by Cilostazol (Compound)