DDInter1662 DDInter1484
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000.
Sertraline {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Plicamycin
Sertraline {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Plicamycin
Sertraline {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Plicamycin
Sertraline {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Plicamycin
Sertraline {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Plicamycin
Sertraline {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Plicamycin
Sertraline {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Levomilnacipran
Levomilnacipran {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Plicamycin
Sertraline {u} (Compound) causes {v} (Side Effect) Metrorrhagia
Metrorrhagia {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Plicamycin
Sertraline {u} (Compound) causes {v} (Side Effect) Face oedema
Face oedema {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Plicamycin
Sertraline {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Norfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Plicamycin
Sertraline (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Gatifloxacin (Compound) and Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Plicamycin
Sertraline (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Gatifloxacin (Compound) and Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Plicamycin
Sertraline (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Sertraline (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Plicamycin
Sertraline (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Plicamycin
Sertraline (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Sertraline (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Levomilnacipran (Compound) and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Sertraline (Compound) causes Metrorrhagia (Side Effect) and Metrorrhagia (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Plicamycin
Sertraline (Compound) causes Face oedema (Side Effect) and Face oedema (Side Effect) is caused by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Plicamycin
Sertraline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Norfloxacin (Compound) and Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Plicamycin