DDInter698 DDInter1731
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Etidronic acid {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Sunitinib
Etidronic acid {u} (Compound) upregulates {v} (Gene) DHX29
DHX29 {u} (Gene) is downregulated by {v} (Compound) Sunitinib
Etidronic acid {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Etidronic acid {u} (Compound) resembles {v} (Compound) Alendronic acid
Alendronic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Etidronic acid {u} (Compound) downregulates {v} (Gene) PUF60
PUF60 {u} (Gene) regulates {v} (Gene) STK10
STK10 {u} (Gene) is bound by {v} (Compound) Sunitinib
Etidronic acid {u} (Compound) upregulates {v} (Gene) DHX29
DHX29 {u} (Gene) is regulated by {v} (Gene) JAK2
JAK2 {u} (Gene) is bound by {v} (Compound) Sunitinib
Etidronic acid {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) resembles {v} (Compound) Sunitinib
Etidronic acid {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sunitinib
Etidronic acid {u} (Compound) causes {v} (Side Effect) Bone pain
Bone pain {u} (Side Effect) is caused by {v} (Compound) Delavirdine
Delavirdine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Etidronic acid {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Etidronic acid (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Sunitinib (Compound)
Etidronic acid (Compound) upregulates DHX29 (Gene) and DHX29 (Gene) is downregulated by Sunitinib (Compound)
Etidronic acid (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Sunitinib (Compound)
Etidronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Etidronic acid (Compound) downregulates PUF60 (Gene) and PUF60 (Gene) regulates STK10 (Gene) and STK10 (Gene) is bound by Sunitinib (Compound)
Etidronic acid (Compound) upregulates DHX29 (Gene) and DHX29 (Gene) is regulated by JAK2 (Gene) and JAK2 (Gene) is bound by Sunitinib (Compound)
Etidronic acid (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Metoclopramide (Compound) and Metoclopramide (Compound) resembles Sunitinib (Compound)
Etidronic acid (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Sunitinib
Etidronic acid (Compound) causes Bone pain (Side Effect) and Bone pain (Side Effect) is caused by Delavirdine (Compound) and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib
Etidronic acid (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib