DDInter336 DDInter1313
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Nalidixic acid
Nalidixic acid {u} (Compound) resembles {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Gemifloxacin
Gemifloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Drug eruption
Drug eruption {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norfloxacin
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2A6
CYP2A6 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Cholestasis
Cholestasis {u} (Side Effect) is caused by {v} (Compound) Mercaptopurine
Mercaptopurine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norfloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Drug eruption
Drug eruption {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norfloxacin
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Norfloxacin (Compound)
Celecoxib (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Norfloxacin (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Norfloxacin (Compound)
Celecoxib (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Nalidixic acid (Compound) and Nalidixic acid (Compound) resembles Norfloxacin (Compound)
Celecoxib (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Gemifloxacin (Compound) and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Celecoxib (Compound) causes Drug eruption (Side Effect) and Drug eruption (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Norfloxacin (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Norfloxacin (Compound)
Celecoxib (Compound) causes Cholestasis (Side Effect) and Cholestasis (Side Effect) is caused by Mercaptopurine (Compound) and Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Norfloxacin
Celecoxib (Compound) causes Drug eruption (Side Effect) and Drug eruption (Side Effect) is caused by Clarithromycin (Compound) and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin