DDInter1789 DDInter1181
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Methsuximide
Thalidomide {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Glutethimide
Glutethimide {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Ketazolam
Ketazolam {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Methsuximide
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Methsuximide (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Methsuximide (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Methsuximide (Compound)
Thalidomide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Methsuximide (Compound)
Thalidomide (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Methsuximide (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Glutethimide (Compound) and Glutethimide (Compound) resembles Methsuximide (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Phenytoin (Compound) and Phenytoin (Compound) resembles Methsuximide (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital (Compound) resembles Methsuximide (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Ketazolam (Compound) and Ketazolam (Compound) resembles Methsuximide (Compound)
Thalidomide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Meperidine (Compound) and Meperidine (Compound) resembles Methsuximide (Compound)