DDInter1397 DDInter453
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Cyclizine
Paroxetine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Cyclizine
Paroxetine {u} (Compound) causes {v} (Side Effect) Thrombophlebitis
Thrombophlebitis {u} (Side Effect) is caused by {v} (Compound) Cyclizine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Cyclizine
Paroxetine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Diphenylpyraline
Diphenylpyraline {u} (Compound) resembles {v} (Compound) Cyclizine
Paroxetine {u} (Compound) causes {v} (Side Effect) Thrombophlebitis
Thrombophlebitis {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Aripiprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Paroxetine {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Paroxetine {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) resembles {v} (Compound) Cyclizine
Paroxetine {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Doxapram
Doxapram {u} (Compound) resembles {v} (Compound) Cyclizine
Paroxetine {u} (Compound) upregulates {v} (Gene) EBP
EBP {u} (Gene) is bound by {v} (Compound) Ifenprodil
Ifenprodil {u} (Compound) resembles {v} (Compound) Cyclizine
Paroxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cyclizine (Compound)
Paroxetine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Cyclizine (Compound)
Paroxetine (Compound) causes Thrombophlebitis (Side Effect) and Thrombophlebitis (Side Effect) is caused by Cyclizine (Compound)
Paroxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Modafinil (Compound) and Modafinil (Compound) resembles Cyclizine (Compound)
Paroxetine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles Cyclizine (Compound)
Paroxetine (Compound) causes Thrombophlebitis (Side Effect) and Thrombophlebitis (Side Effect) is caused by Aripiprazole (Compound) and Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Paroxetine (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Paroxetine (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Cyclizine (Compound)
Paroxetine (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Doxapram (Compound) and Doxapram (Compound) resembles Cyclizine (Compound)
Paroxetine (Compound) upregulates EBP (Gene) and EBP (Gene) is bound by Ifenprodil (Compound) and Ifenprodil (Compound) resembles Cyclizine (Compound)