DDInter336 DDInter1366
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The first oxycodone containing product, Percodan, was approved by the FDA on April 12, 1950.
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Oxycodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Deep vein thrombosis
Deep vein thrombosis {u} (Side Effect) is caused by {v} (Compound) Oxycodone
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Hydromorphone
Hydromorphone {u} (Compound) resembles {v} (Compound) Oxycodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Deep vein thrombosis
Deep vein thrombosis {u} (Side Effect) is caused by {v} (Compound) Naltrexone
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Oxycodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Hyperhidrosis {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} (Compound) resembles {v} (Compound) Oxycodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Sepsis
Sepsis {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Dolasetron {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxycodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxycodone
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Oxycodone
Celecoxib {u} (Compound) causes {v} (Side Effect) Pneumonia
Pneumonia {u} (Side Effect) is caused by {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Oxycodone
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Vemurafenib
Vemurafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxycodone
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxycodone (Compound)
Celecoxib (Compound) causes Deep vein thrombosis (Side Effect) and Deep vein thrombosis (Side Effect) is caused by Oxycodone (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Hydromorphone (Compound) and Hydromorphone (Compound) resembles Oxycodone (Compound)
Celecoxib (Compound) causes Deep vein thrombosis (Side Effect) and Deep vein thrombosis (Side Effect) is caused by Naltrexone (Compound) and Naltrexone may lead to a major life threatening interaction when taken with Oxycodone
Celecoxib (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone (Compound) resembles Oxycodone (Compound)
Celecoxib (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Dolasetron (Compound) and Dolasetron may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone
Celecoxib (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxycodone (Compound)
Celecoxib (Compound) causes Pneumonia (Side Effect) and Pneumonia (Side Effect) is caused by Oxymorphone (Compound) and Oxymorphone (Compound) resembles Oxycodone (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) resembles Vemurafenib (Compound) and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone