DDInter1834 DDInter1879
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Triprolidine
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Triprolidine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Clonazepam
Clonazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Topiramate {u} (Compound) downregulates {v} (Gene) SMC1A
SMC1A {u} (Gene) is regulated by {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Triprolidine
Topiramate {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Triprolidine
Topiramate {u} (Compound) downregulates {v} (Gene) SMC1A
SMC1A {u} (Gene) is downregulated by {v} (Compound) Darifenacin
Darifenacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Topiramate {u} (Compound) downregulates {v} (Gene) PROCR
PROCR {u} (Gene) regulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Triprolidine
Topiramate {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) regulates {v} (Gene) IGFBP3
IGFBP3 {u} (Gene) is downregulated by {v} (Compound) Triprolidine
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Triprolidine (Compound)
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Clonazepam (Compound) and Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Topiramate (Compound) downregulates SMC1A (Gene) and SMC1A (Gene) is regulated by NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Triprolidine (Compound)
Topiramate (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Triprolidine (Compound)
Topiramate (Compound) downregulates SMC1A (Gene) and SMC1A (Gene) is downregulated by Darifenacin (Compound) and Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Topiramate (Compound) downregulates PROCR (Gene) and PROCR (Gene) regulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Triprolidine (Compound)
Topiramate (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) regulates IGFBP3 (Gene) and IGFBP3 (Gene) is downregulated by Triprolidine (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine