DDInter1938 DDInter150
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Vincristine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Vincristine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Vincristine {u} (Compound) upregulates {v} (Gene) F3
F3 {u} (Gene) is associated with {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) regulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) upregulates {v} (Gene) F3
F3 {u} (Gene) is upregulated by {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) upregulates {v} (Gene) GADD45A
GADD45A {u} (Gene) interacts with {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) upregulates {v} (Gene) F3
F3 {u} (Gene) regulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Vincristine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Vincristine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Azathioprine (Compound)
Vincristine (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Azathioprine (Compound)
Vincristine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by RRP1B (Gene) and RRP1B (Gene) is downregulated by Azathioprine (Compound)
Vincristine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Vincristine (Compound) upregulates F3 (Gene) and F3 (Gene) is associated with systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Vincristine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) regulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)
Vincristine (Compound) upregulates F3 (Gene) and F3 (Gene) is upregulated by ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Azathioprine (Compound)
Vincristine (Compound) upregulates GADD45A (Gene) and GADD45A (Gene) interacts with NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Vincristine (Compound) upregulates F3 (Gene) and F3 (Gene) regulates GTPBP8 (Gene) and GTPBP8 (Gene) is upregulated by Azathioprine (Compound)
Vincristine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) interacts with PLK1 (Gene) and MCM3 (Gene) regulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Azathioprine (Compound)