DDInter1744 DDInter1610
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole]. Tamoxifen was granted FDA approval on 30 December 1977.
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Tamoxifen {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) upregulates {v} (Gene) GHR
GHR {u} (Gene) is upregulated by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) downregulates {v} (Gene) CCNH
CCNH {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pyridostigmine
Pyridostigmine {u} (Compound) resembles {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tapentadol
Tapentadol {u} (Compound) resembles {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) upregulates {v} (Gene) GHR
GHR {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) upregulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is regulated by {v} (Gene) GDPD5
GDPD5 {u} (Gene) is upregulated by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) downregulates {v} (Gene) CCNH
CCNH {u} (Gene) is downregulated by {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Rivastigmine
Tamoxifen {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Rivastigmine
Tamoxifen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivastigmine (Compound)
Tamoxifen (Compound) upregulates GHR (Gene) and GHR (Gene) is upregulated by Rivastigmine (Compound)
Tamoxifen (Compound) downregulates CCNH (Gene) and CCNH (Gene) is downregulated by Rivastigmine (Compound)
Tamoxifen (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivastigmine (Compound)
Tamoxifen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pyridostigmine (Compound) and Pyridostigmine (Compound) resembles Rivastigmine (Compound)
Tamoxifen (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tapentadol (Compound) and Tapentadol (Compound) resembles Rivastigmine (Compound)
Tamoxifen (Compound) upregulates GHR (Gene) and GHR (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Rivastigmine (Compound)
Tamoxifen (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is regulated by GDPD5 (Gene) and GDPD5 (Gene) is upregulated by Rivastigmine (Compound)
Tamoxifen (Compound) downregulates CCNH (Gene) and CCNH (Gene) is downregulated by Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Rivastigmine (Compound)
Tamoxifen (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Rivastigmine (Compound)