DDInter458 DDInter1832
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Tolterodine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Tolterodine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Tolterodine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Brompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Fesoterodine
Fesoterodine {u} (Compound) resembles {v} (Compound) Tolterodine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Influenza-like symptoms
Influenza-like symptoms {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Influenza like illness
Influenza like illness {u} (Side Effect) is caused by {v} (Compound) Terbinafine
Terbinafine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Influenza-like symptoms
Influenza-like symptoms {u} (Side Effect) is caused by {v} (Compound) Tiotropium
Tiotropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abnormal vision
Abnormal vision {u} (Side Effect) is caused by {v} (Compound) Trospium
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolterodine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tolterodine (Compound)
Cyclosporine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Tolterodine (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Atomoxetine (Compound) and Atomoxetine (Compound) resembles Tolterodine (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Brompheniramine (Compound) and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine
Cyclosporine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Fesoterodine (Compound) and Fesoterodine (Compound) resembles Tolterodine (Compound)
Cyclosporine (Compound) causes Influenza-like symptoms (Side Effect) and Influenza-like symptoms (Side Effect) is caused by Bupropion (Compound) and Bupropion may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Cyclosporine (Compound) causes Influenza like illness (Side Effect) and Influenza like illness (Side Effect) is caused by Terbinafine (Compound) and Terbinafine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Cyclosporine (Compound) causes Influenza-like symptoms (Side Effect) and Influenza-like symptoms (Side Effect) is caused by Tiotropium (Compound) and Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine
Cyclosporine (Compound) causes Abnormal vision (Side Effect) and Abnormal vision (Side Effect) is caused by Trospium (Compound) and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Tolterodine