DDInter1233 DDInter1609
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) regulates {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) downregulates {v} (Gene) PAPD7
PAPD7 {u} (Gene) is regulated by {v} (Gene) F10
F10 {u} (Gene) is bound by {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rivaroxaban
Mitotane {u} (Compound) causes {v} (Side Effect) Infestation
Infestation {u} (Side Effect) is caused by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rivaroxaban
Mitotane {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Linezolid
Linezolid {u} (Compound) resembles {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is regulated by {v} (Gene) SHB
SHB {u} (Gene) is downregulated by {v} (Compound) Rivaroxaban
Mitotane {u} (Compound) causes {v} (Side Effect) Infestation
Infestation {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rivaroxaban
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Rivaroxaban (Compound)
Mitotane (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Rivaroxaban (Compound)
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) regulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Rivaroxaban (Compound)
Mitotane (Compound) downregulates PAPD7 (Gene) and PAPD7 (Gene) is regulated by F10 (Gene) and F10 (Gene) is bound by Rivaroxaban (Compound)
Mitotane (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Mitotane (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Mitotane (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Linezolid (Compound) and Linezolid (Compound) resembles Rivaroxaban (Compound)
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivaroxaban (Compound)
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is regulated by SHB (Gene) and SHB (Gene) is downregulated by Rivaroxaban (Compound)
Mitotane (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban