DDInter1008 DDInter76
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Ketoconazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) is included by {v} (Pharmacologic Class) P-Glycoprotein Inhibitors
P-Glycoprotein Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) causes {v} (Side Effect) Dermatitis exfoliative
Dermatitis exfoliative {u} (Side Effect) is caused by {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiodarone
Ketoconazole {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dronedarone
Dronedarone {u} (Compound) resembles {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) regulates {v} (Gene) WDR7
WDR7 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Ketoconazole {u} (Compound) upregulates {v} (Gene) ALDOC
ALDOC {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Amiodarone
Ketoconazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Ketoconazole (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Amiodarone (Compound)
Ketoconazole (Compound) binds CYP51A1 (Gene) and Ketoconazole (Compound) upregulates CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Amiodarone (Compound)
Ketoconazole (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class) and P-Glycoprotein Inhibitors (Pharmacologic Class) includes Amiodarone (Compound)
Ketoconazole (Compound) causes Dermatitis exfoliative (Side Effect) and Dermatitis exfoliative (Side Effect) is caused by Amiodarone (Compound)
Ketoconazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone
Ketoconazole (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Amiodarone (Compound)
Ketoconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dronedarone (Compound) and Dronedarone (Compound) resembles Amiodarone (Compound)
Ketoconazole (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) regulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Amiodarone (Compound)
Ketoconazole (Compound) upregulates ALDOC (Gene) and ALDOC (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Amiodarone (Compound)