DDInter336 DDInter900
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID. On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) binds {v} (Gene) ABCC4
ABCC4 {u} (Gene) is bound by {v} (Compound) Probenecid
Probenecid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Naproxen
Naproxen {u} (Compound) resembles {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Baclofen
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Celecoxib {u} (Compound) causes {v} (Side Effect) Pancreatitis acute
Pancreatitis acute {u} (Side Effect) is caused by {v} (Compound) Ranitidine
Ranitidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Ibuprofen (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Ibuprofen (Compound)
Celecoxib (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Celecoxib (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Probenecid (Compound) and Probenecid may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Naproxen (Compound) and Naproxen (Compound) resembles Ibuprofen (Compound)
Celecoxib (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Baclofen (Compound) and Baclofen (Compound) resembles Ibuprofen (Compound)
Celecoxib (Compound) causes Pancreatitis acute (Side Effect) and Pancreatitis acute (Side Effect) is caused by Ranitidine (Compound) and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Ibuprofen