DDInter1397 DDInter569
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed for use within many non-prescription over-the-counter sleep aids and cough-and-cold medications that have been marketed for "night time" use [L5263, L5281, L5287]. Diphenhydramine is also used in combination with as the anti-nausea drug where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system . Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid . As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Paroxetine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Diphenhydramine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Cinnarizine
Cinnarizine {u} (Compound) resembles {v} (Compound) Diphenhydramine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Bepridil
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Paroxetine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Diphenhydramine
Paroxetine {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Tropicamide
Tropicamide {u} (Compound) resembles {v} (Compound) Diphenhydramine
Paroxetine {u} (Compound) causes {v} (Side Effect) Extrasystoles
Extrasystoles {u} (Side Effect) is caused by {v} (Compound) Dimenhydrinate
Dimenhydrinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Paroxetine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Bepridil
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Diphenhydramine
Paroxetine {u} (Compound) binds {v} (Gene) CHRM2
CHRM2 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Paroxetine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Diphenhydramine (Compound)
Paroxetine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Diphenhydramine (Compound)
Paroxetine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Cinnarizine (Compound) and Cinnarizine (Compound) resembles Diphenhydramine (Compound)
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bepridil (Compound) and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Paroxetine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Toremifene (Compound) and Toremifene (Compound) resembles Diphenhydramine (Compound)
Paroxetine (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Tropicamide (Compound) and Tropicamide (Compound) resembles Diphenhydramine (Compound)
Paroxetine (Compound) causes Extrasystoles (Side Effect) and Extrasystoles (Side Effect) is caused by Dimenhydrinate (Compound) and Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Paroxetine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bepridil (Compound) and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Toremifene (Compound) and Toremifene (Compound) resembles Diphenhydramine (Compound)
Paroxetine (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine