DDInter1233 DDInter1744
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole]. Tamoxifen was granted FDA approval on 30 December 1977.
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Tamoxifen
Mitotane {u} (Compound) downregulates {v} (Gene) HMGCR
HMGCR {u} (Gene) is upregulated by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tamoxifen
Mitotane {u} (Compound) causes {v} (Side Effect) Retinal disorder
Retinal disorder {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Doxylamine {u} (Compound) resembles {v} (Compound) Tamoxifen
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Tamoxifen (Compound)
Mitotane (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Tamoxifen (Compound)
Mitotane (Compound) downregulates HMGCR (Gene) and HMGCR (Gene) is upregulated by Clomifene (Compound) and Clomifene (Compound) resembles Tamoxifen (Compound)
Mitotane (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Clomifene (Compound) and Clomifene (Compound) resembles Tamoxifen (Compound)
Mitotane (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Tamoxifen
Mitotane (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Tamoxifen
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Naftifine (Compound) and Naftifine (Compound) resembles Tamoxifen (Compound)
Mitotane (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tamoxifen
Mitotane (Compound) causes Retinal disorder (Side Effect) and Retinal disorder (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Tamoxifen (Compound)