DDInter1938 DDInter1325
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Vincristine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Ofloxacin
Vincristine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Ofloxacin
Vincristine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Vincristine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Vincristine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Vinblastine
Vinblastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Vincristine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Vincristine {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Vincristine {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Vincristine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Ofloxacin (Compound)
Vincristine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Ofloxacin (Compound)
Vincristine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Ofloxacin (Compound)
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin
Vincristine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Vincristine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Vinblastine (Compound) and Vinblastine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin
Vincristine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Ofloxacin (Compound)
Vincristine (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Vincristine (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Ofloxacin (Compound)