DDInter1009 DDInter856
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Ketoprofen {u} (Compound) resembles {v} (Compound) Alvimopan
Ketoprofen {u} (Compound) resembles {v} (Compound) Tropicamide
Ketoprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Ketoprofen {u} (Compound) binds {v} (Gene) CXCL8
Ketoprofen {u} (Compound) upregulates {v} (Gene) AGR2
Ketoprofen {u} (Compound) palliates {v} (Disease) osteoarthritis
Ketoprofen {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Ketoprofen {u} (Compound) downregulates {v} (Gene) THAP11
Ketoprofen {u} (Compound) causes {v} (Side Effect) Sepsis
Ketoprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Ketoprofen (Compound) resembles Alvimopan (Compound)
Ketoprofen (Compound) resembles Tropicamide (Compound)
Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Ketoprofen (Compound) binds CXCL8 (Gene)
Ketoprofen (Compound) upregulates AGR2 (Gene)
Ketoprofen (Compound) palliates osteoarthritis (Disease)
Ketoprofen (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Ketoprofen (Compound) downregulates THAP11 (Gene)
Ketoprofen (Compound) causes Sepsis (Side Effect)
Ketoprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine