DDInter246 DDInter1376
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Budesonide {u} (Compound) resembles {v} (Compound) Flurandrenolide
Budesonide {u} (Compound) treats {v} (Disease) asthma
Budesonide {u} (Compound) binds {v} (Gene) CYP3A4
Budesonide {u} (Compound) upregulates {v} (Gene) P4HA2
Budesonide {u} (Compound) is included by {v} (Pharmacologic Class) Corticosteroid Hormone Receptor Agonists
Budesonide {u} (Compound) downregulates {v} (Gene) RAP1GAP
Budesonide {u} (Compound) causes {v} (Side Effect) Pain
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Isoprenaline
Budesonide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Budesonide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ipilimumab
Budesonide (Compound) resembles Flurandrenolide (Compound)
Budesonide (Compound) treats asthma (Disease)
Budesonide (Compound) binds CYP3A4 (Gene)
Budesonide (Compound) upregulates P4HA2 (Gene)
Budesonide (Compound) is included by Corticosteroid Hormone Receptor Agonists (Pharmacologic Class)
Budesonide (Compound) downregulates RAP1GAP (Gene)
Budesonide (Compound) causes Pain (Side Effect)
Budesonide may cause a minor interaction that can limit clinical effects when taken with Isoprenaline
Budesonide may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab