DDInter1042 DDInter1084
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Moxifloxacin
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
Lomefloxacin {u} (Compound) causes {v} (Side Effect) Potassium low
Lomefloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Daunorubicin
Lomefloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cytarabine
Lomefloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisacodyl
Lomefloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxsalen
Lomefloxacin {u} may lead to a major life threatening interaction when taken with {v} Methylprednisolone
Lomefloxacin {u} may lead to a major life threatening interaction when taken with {v} Ivosidenib
Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Lomefloxacin (Compound) resembles Moxifloxacin (Compound)
Lomefloxacin (Compound) binds TOP2A (Gene)
Lomefloxacin (Compound) causes Potassium low (Side Effect)
Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Daunorubicin
Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Cytarabine
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Methoxsalen
Lomefloxacin may lead to a major life threatening interaction when taken with Methylprednisolone
Lomefloxacin may lead to a major life threatening interaction when taken with Ivosidenib