DDInter1520 DDInter1658
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Primaquine {u} (Compound) resembles {v} (Compound) Chloroquine
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Primaquine {u} (Compound) binds {v} (Gene) SENP8
Primaquine {u} (Compound) downregulates {v} (Gene) PSMB8
Primaquine {u} (Compound) causes {v} (Side Effect) Nausea
Primaquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promazine
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Romidepsin
Primaquine {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Primaquine (Compound) resembles Chloroquine (Compound)
Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Primaquine (Compound) binds SENP8 (Gene)
Primaquine (Compound) downregulates PSMB8 (Gene)
Primaquine (Compound) causes Nausea (Side Effect)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Promazine
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Primaquine may lead to a major life threatening interaction when taken with Prilocaine