DDInter596 DDInter1335
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Doxorubicin {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) downregulates {v} (Gene) ARID4B
ARID4B {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) downregulates {v} (Gene) B4GAT1
B4GAT1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) upregulates {v} (Gene) NENF
NENF {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) binds {v} (Gene) CBR1
CBR1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is regulated by {v} (Gene) COG4
COG4 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) downregulates {v} (Gene) ARID4B
ARID4B {u} (Gene) interacts with {v} (Gene) ETS1
ETS1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) regulates {v} (Gene) CHIC2
CHIC2 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin {u} (Compound) downregulates {v} (Gene) DNTTIP2
DNTTIP2 {u} (Gene) regulates {v} (Gene) ATF6
ATF6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Doxorubicin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) downregulates ARID4B (Gene) and ARID4B (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) upregulates NENF (Gene) and NENF (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) binds CBR1 (Gene) and CBR1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Doxorubicin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is regulated by COG4 (Gene) and COG4 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) downregulates ARID4B (Gene) and ARID4B (Gene) interacts with ETS1 (Gene) and ETS1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) regulates CHIC2 (Gene) and CHIC2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Doxorubicin (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) regulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)