DDInter1091 DDInter624
Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Loratadine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Loratadine {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Loratadine {u} (Compound) resembles {v} (Compound) Desloratadine
Desloratadine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Efavirenz
Loratadine {u} (Compound) resembles {v} (Compound) Ketotifen
Ketotifen {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Loratadine {u} (Compound) resembles {v} (Compound) Alcaftadine
Alcaftadine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Loratadine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Loratadine {u} (Compound) downregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) regulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Loratadine {u} (Compound) downregulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) interacts with {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Loratadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clarithromycin
Clarithromycin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Loratadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Fluconazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Loratadine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)
Loratadine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Efavirenz (Compound)
Loratadine (Compound) resembles Desloratadine (Compound) and Desloratadine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Efavirenz (Compound)
Loratadine (Compound) resembles Ketotifen (Compound) and Ketotifen (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Efavirenz (Compound)
Loratadine (Compound) resembles Alcaftadine (Compound) and Alcaftadine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Efavirenz (Compound)
Loratadine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Efavirenz (Compound)
Loratadine (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) regulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Efavirenz (Compound)
Loratadine (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) interacts with IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Loratadine may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)
Loratadine may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)