DDInter1861 DDInter1376
A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Benzthiazide
Trichlormethiazide {u} (Compound) resembles {v} (Compound) Polythiazide
Trichlormethiazide {u} (Compound) binds {v} (Gene) TPMT
Trichlormethiazide {u} (Compound) upregulates {v} (Gene) TSEN2
Trichlormethiazide {u} (Compound) downregulates {v} (Gene) MRPL19
Trichlormethiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dicyclomine
Trichlormethiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mepenzolate
Trichlormethiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabilone
Trichlormethiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dulaglutide
Trichlormethiazide {u} may lead to a major life threatening interaction when taken with {v} Arsenic trioxide
Trichlormethiazide (Compound) resembles Benzthiazide (Compound)
Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Trichlormethiazide (Compound) binds TPMT (Gene)
Trichlormethiazide (Compound) upregulates TSEN2 (Gene)
Trichlormethiazide (Compound) downregulates MRPL19 (Gene)
Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Mepenzolate
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Nabilone
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide
Trichlormethiazide may lead to a major life threatening interaction when taken with Arsenic trioxide