DDInter485 DDInter150
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Daunorubicin {u} (Compound) binds {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) upregulates {v} (Gene) ADAT1
ADAT1 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Daunorubicin {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Daunorubicin (Compound) binds XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)
Daunorubicin (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Daunorubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Daunorubicin (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Azathioprine (Compound)
Daunorubicin (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Azathioprine (Compound)
Daunorubicin (Compound) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Azathioprine (Compound)
Daunorubicin (Compound) upregulates ADAT1 (Gene) and ADAT1 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Daunorubicin (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Daunorubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Daunorubicin (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)