DDInter1607 DDInter413
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease, It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin. Clopidogrel was granted FDA approval on 17 November 1997.
Ritonavir {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Clopidogrel
Ritonavir {u} (Compound) causes {v} (Side Effect) Deafness
Deafness {u} (Side Effect) is caused by {v} (Compound) Clopidogrel
Ritonavir {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Clopidogrel
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Clopidogrel
Ritonavir {u} (Compound) causes {v} (Side Effect) Deafness
Deafness {u} (Side Effect) is caused by {v} (Compound) Fosphenytoin
Fosphenytoin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clopidogrel
Ritonavir {u} (Compound) causes {v} (Side Effect) Ecchymosis
Ecchymosis {u} (Side Effect) is caused by {v} (Compound) Ticlopidine
Ticlopidine {u} may lead to a major life threatening interaction when taken with {v} Clopidogrel
Ritonavir {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clopidogrel
Ritonavir {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Tapentadol
Tapentadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clopidogrel
Ritonavir {u} (Compound) causes {v} (Side Effect) Urinary tract disorder
Urinary tract disorder {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clopidogrel
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clopidogrel
Ritonavir (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Clopidogrel (Compound)
Ritonavir (Compound) causes Deafness (Side Effect) and Deafness (Side Effect) is caused by Clopidogrel (Compound)
Ritonavir (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Ritonavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Clopidogrel (Compound)
Ritonavir (Compound) causes Deafness (Side Effect) and Deafness (Side Effect) is caused by Fosphenytoin (Compound) and Fosphenytoin may cause a minor interaction that can limit clinical effects when taken with Clopidogrel
Ritonavir (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Ticlopidine (Compound) and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Ritonavir (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Tamoxifen (Compound) and Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Clopidogrel
Ritonavir (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Tapentadol (Compound) and Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel
Ritonavir (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clopidogrel (Compound)