DDInter458 DDInter1371
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth in malnourished or underdeveloped patients. Anabolic-androgenic steroids (AAS), such as oxymetholone, have been abused by bodybuilders and athletes. The uncontrolled misuse of oxymetholone can lead to a large variety of detrimental effects, the most often reported of which are cardiovascular events. In 2009, no producers of oxymetholone were identified worldwide (SRI 2009), but it was available from 14 suppliers, including 8 U.S. suppliers (ChemSources 2009).
Cyclosporine {u} (Compound) treats {v} (Disease) focal segmental glomerulosclerosis
Cyclosporine {u} (Compound) binds {v} (Gene) SLC10A2
Cyclosporine {u} (Compound) upregulates {v} (Gene) IFRD1
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) P-Glycoprotein Inhibitors
Cyclosporine {u} (Compound) downregulates {v} (Gene) CENPF
Cyclosporine {u} (Compound) causes {v} (Side Effect) Injury
Cyclosporine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) PPIB
Cyclosporine (Compound) treats focal segmental glomerulosclerosis (Disease)
Cyclosporine (Compound) binds SLC10A2 (Gene)
Cyclosporine (Compound) upregulates IFRD1 (Gene)
Cyclosporine (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class)
Cyclosporine (Compound) downregulates CENPF (Gene)
Cyclosporine (Compound) causes Injury (Side Effect)
Cyclosporine (Compound) binds PPIB (Gene) and Cyclosporine (Compound) upregulates PPIB (Gene)