DDInter1936 DDInter150
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Vinblastine {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) SUZ12
SUZ12 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Tioguanine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) SUZ12
SUZ12 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Vinblastine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) regulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Vinblastine (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) is downregulated by Azathioprine (Compound)
Vinblastine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Azathioprine (Compound)
Vinblastine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by RRP1B (Gene) and RRP1B (Gene) is downregulated by Azathioprine (Compound)
Vinblastine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Vinblastine (Compound) downregulates SUZ12 (Gene) and SUZ12 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Vinblastine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Azathioprine (Compound)
Vinblastine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Vinblastine (Compound) downregulates SUZ12 (Gene) and SUZ12 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Vinblastine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) regulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)