DDInter1622 DDInter1752
Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2
Drug-resistant bacteria, such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved [linezolid] and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and is generally more effective and more tolerable than [linezolid].[L11232, A199086, A199050] Tedizolid was approved by the FDA on June 20, 2014, for sale by Cubist Pharmaceuticals as tedizolid phosphate (SIVEXTRO®). This product is currently available as both an oral tablet and as a powder for intravenous injection.
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvastatin
Rosuvastatin {u} (Compound) treats {v} (Disease) atherosclerosis
Rosuvastatin {u} (Compound) binds {v} (Gene) ABCC1
Rosuvastatin {u} (Compound) upregulates {v} (Gene) STX1A
Rosuvastatin {u} (Compound) downregulates {v} (Gene) CYR61
Rosuvastatin {u} (Compound) causes {v} (Side Effect) Influenza
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Desogestrel
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norgestrel
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lorlatinib
Rosuvastatin {u} may lead to a major life threatening interaction when taken with {v} Nelfinavir
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin
Rosuvastatin (Compound) treats atherosclerosis (Disease)
Rosuvastatin (Compound) binds ABCC1 (Gene)
Rosuvastatin (Compound) upregulates STX1A (Gene)
Rosuvastatin (Compound) downregulates CYR61 (Gene)
Rosuvastatin (Compound) causes Influenza (Side Effect)
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Desogestrel
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Rosuvastatin may lead to a major life threatening interaction when taken with Nelfinavir