DDInter1639 DDInter990
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Like other organic nitrates, isosorbide mononitrate acts as a prodrug for its active metabolite, [nitric oxide], which mediates the therapeutic action of isosorbide mononitrate. Isosorbide mononitrate has a longer duration of action than [nitroglycerin] due to its slow onset of absorption and metabolism. First approved by the FDA in 1991, isosorbide mononitrate is used for the prevention and management of angina pectoris caused by coronary artery disease; however, the onset of action of orally-administered isosorbide mononitrate is not rapid enough to offset an acute anginal episode. It is available in oral tablets generically and under the brand name ISMO and Monoket. The extended-release forms of the drug are also available generically and under the brand name Imdur.
Sapropterin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Isosorbide mononitrate
Sapropterin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Isosorbide dinitrate
Isosorbide dinitrate {u} (Compound) resembles {v} (Compound) Isosorbide mononitrate
Sapropterin {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide mononitrate
Sapropterin {u} (Compound) causes {v} (Side Effect) Malnutrition
Malnutrition {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide mononitrate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) interacts with {v} (Gene) GUCY1B3
GUCY1B3 {u} (Gene) is bound by {v} (Compound) Isosorbide mononitrate
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Dapsone
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide mononitrate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is palliated by {v} (Compound) Isosorbide mononitrate
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide mononitrate
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide mononitrate
Sapropterin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Alimemazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isosorbide mononitrate
Sapropterin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isosorbide mononitrate (Compound)
Sapropterin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isosorbide dinitrate (Compound) and Isosorbide dinitrate (Compound) resembles Isosorbide mononitrate (Compound)
Sapropterin (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate
Sapropterin (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Morphine (Compound) and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) interacts with GUCY1B3 (Gene) and GUCY1B3 (Gene) is bound by Isosorbide mononitrate (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Dapsone (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is palliated by Isosorbide mononitrate (Compound)
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate
Sapropterin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide mononitrate