DDInter458 DDInter1859
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on the distal nephron where only a small fraction of sodium ion reabsorption occurs, triamterene is reported to have limited diuretic efficacy. Due to its effects on increased serum potassium levels, triamterene is associated with a risk of producing hyperkalemia. Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. Triamterene was approved by the Food and Drug Administration in the U.S. in 1964. Currently, triamterene is used in the treatment of edema associated with various conditions as monotherapy and is approved for use with other diuretics to enhance diuretic and potassium-sparing effects. It is also found in a combination product with hydrochlorothiazide that is used for the management of hypertension or treatment of edema in patients who develop hypokalemia on hydrochlorothiazide alone.
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Triamterene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Triamterene
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) SCNN1A
SCNN1A {u} (Gene) is bound by {v} (Compound) Triamterene
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is regulated by {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Triamterene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Lamotrigine
Lamotrigine {u} (Compound) resembles {v} (Compound) Triamterene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Azotaemia
Azotaemia {u} (Side Effect) is caused by {v} (Compound) Metformin
Metformin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamterene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Blood urea increased
Blood urea increased {u} (Side Effect) is caused by {v} (Compound) Iodixanol
Iodixanol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamterene
Cyclosporine {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Famotidine
Famotidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Triamterene
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Lamotrigine
Lamotrigine {u} (Compound) resembles {v} (Compound) Triamterene
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Triamterene
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Triamterene (Compound)
Cyclosporine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Triamterene (Compound)
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by SCNN1A (Gene) and SCNN1A (Gene) is bound by Triamterene (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is regulated by CDC20 (Gene) and CDC20 (Gene) is downregulated by Triamterene (Compound)
Cyclosporine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Lamotrigine (Compound) and Lamotrigine (Compound) resembles Triamterene (Compound)
Cyclosporine (Compound) causes Azotaemia (Side Effect) and Azotaemia (Side Effect) is caused by Metformin (Compound) and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Triamterene
Cyclosporine (Compound) causes Blood urea increased (Side Effect) and Blood urea increased (Side Effect) is caused by Iodixanol (Compound) and Iodixanol may cause a moderate interaction that could exacerbate diseases when taken with Triamterene
Cyclosporine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound) and Famotidine may cause a minor interaction that can limit clinical effects when taken with Triamterene
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lamotrigine (Compound) and Lamotrigine (Compound) resembles Triamterene (Compound)
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Triamterene (Compound)