DDInter1287 DDInter1652
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Nicardipine {u} (Compound) resembles {v} (Compound) Felodipine
Nicardipine {u} (Compound) resembles {v} (Compound) Clevidipine
Nicardipine {u} (Compound) treats {v} (Disease) hypertension
Nicardipine {u} (Compound) binds {v} (Gene) PDE1A
Nicardipine {u} (Compound) upregulates {v} (Gene) NNT
Nicardipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Nicardipine {u} (Compound) downregulates {v} (Gene) CAST
Nicardipine {u} (Compound) causes {v} (Side Effect) Nervousness
Nicardipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Acetylsalicylic acid
Nicardipine (Compound) resembles Felodipine (Compound)
Nicardipine (Compound) resembles Clevidipine (Compound)
Nicardipine (Compound) treats hypertension (Disease)
Nicardipine (Compound) binds PDE1A (Gene)
Nicardipine (Compound) upregulates NNT (Gene)
Nicardipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Nicardipine (Compound) downregulates CAST (Gene)
Nicardipine (Compound) causes Nervousness (Side Effect)
Nicardipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid