DDInter1276 DDInter998
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis_. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>). Ivermectin is mainly used in humans in the treatment of onchocerciasis, but may also be effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis). Applied topically, it may be used in the treatment of head lice infestation. With the advent of 2020 and the COVID-19 pandemic, ivermectin began garnering notoriety due to its off-label use for the prophylaxis and treatment of COVID-19. While studies are still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and the clinical utility of this data remains unclear. Due to a number of factors - for example, the relatively low number of patients per trial and the speed at which these trials were conducted - studies on the use of ivermectin in COVID-19 have been fraught with statistical errors and accusations of plagiarism.[L36763,A238929] In addition, the use of aggregate patient data in large-scale meta-analyses (as opposed to individual patient data (IPD)) has been shown to disguise otherwise blatant data errors, such as extreme terminal digit bias and the duplication of blocks of patient records. Until high-quality, peer-reviewed data regarding both the safety and efficacy of ivermectin for COVID-19 in humans becomes available, the use of ivermectin for these purposes should be avoided in favour of thoroughly-vetted therapies (e.g. COVID-19 vaccines like [Comirnaty](https://go.drugbank.com/drugs/DB15696)).
Nelfinavir {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) regulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) is downregulated by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is regulated by {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) upregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) regulates {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Ivermectin
Nelfinavir {u} (Compound) upregulates {v} (Gene) ASNS
ASNS {u} (Gene) interacts with {v} (Gene) ATF3
ATF3 {u} (Gene) is upregulated by {v} (Compound) Ivermectin
Nelfinavir (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Ivermectin (Compound)
Nelfinavir (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Ivermectin (Compound)
Nelfinavir (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Ivermectin (Compound)
Nelfinavir (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ivermectin (Compound)
Nelfinavir (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) regulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Ivermectin (Compound)
Nelfinavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with PGRMC1 (Gene) and PGRMC1 (Gene) is downregulated by Ivermectin (Compound)
Nelfinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ivermectin (Compound)
Nelfinavir (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is regulated by TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ivermectin (Compound)
Nelfinavir (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) regulates ABCC1 (Gene) and ABCC1 (Gene) is bound by Ivermectin (Compound)
Nelfinavir (Compound) upregulates ASNS (Gene) and ASNS (Gene) interacts with ATF3 (Gene) and ATF3 (Gene) is upregulated by Ivermectin (Compound)