DDInter507 DDInter790
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH. It has been employed clinically since 1972
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients. The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.
Desmopressin {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Furosemide
Desmopressin {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Desmopressin {u} (Compound) resembles {v} (Compound) Terlipressin
Terlipressin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Furosemide
Desmopressin {u} (Compound) resembles {v} (Compound) Gonadorelin
Gonadorelin {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Furosemide
Desmopressin {u} (Compound) binds {v} (Gene) AVPR2
AVPR2 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Furosemide
Desmopressin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Bumetanide
Bumetanide {u} (Compound) resembles {v} (Compound) Furosemide
Desmopressin {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Furosemide
Desmopressin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) treats {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Furosemide
Desmopressin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Amitriptyline {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Furosemide
Desmopressin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acetylsalicylic acid
Acetylsalicylic acid {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Furosemide
Desmopressin (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Furosemide (Compound)
Desmopressin (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Furosemide (Compound)
Desmopressin (Compound) resembles Terlipressin (Compound) and Terlipressin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Furosemide (Compound)
Desmopressin (Compound) resembles Gonadorelin (Compound) and Gonadorelin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Furosemide (Compound)
Desmopressin (Compound) binds AVPR2 (Gene) and AVPR2 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Furosemide (Compound)
Desmopressin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Bumetanide (Compound) and Bumetanide (Compound) resembles Furosemide (Compound)
Desmopressin (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Furosemide (Compound)
Desmopressin may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Furosemide (Compound)
Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) binds ALB (Gene) and ALB (Gene) is bound by Furosemide (Compound)
Desmopressin may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid and Acetylsalicylic acid (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Furosemide (Compound)