DDInter542 DDInter380
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Cimetidine
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Ketoprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Cimetidine
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Indomethacin
Indomethacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is associated with {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Cimetidine
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) regulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Cimetidine
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) regulates {v} (Gene) SLC47A1
SLC47A1 {u} (Gene) is bound by {v} (Compound) Cimetidine
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cimetidine (Compound)
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ketoprofen (Compound) and Ketoprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cimetidine (Compound)
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Indomethacin (Compound) and Indomethacin may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) is associated with obesity (Disease) and obesity (Disease) is treated by Cimetidine (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) regulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Cimetidine (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) regulates SLC47A1 (Gene) and SLC47A1 (Gene) is bound by Cimetidine (Compound)
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine