DDInter458 DDInter1855
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermatoses. Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.[L8246,L8249,L8252,L8255,L8258,L8261,L8264] Triamcinolone was granted FDA approval on 3 December 1957. In October 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection - the first suprachoroidal injection to receive FDA approval - for the treatment of patients with macular edema associated with uveitis.
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) upregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is downregulated by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Acute coronary syndrome {u} (Side Effect) is caused by {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Prednisone
Prednisone {u} (Compound) resembles {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Prednisone
Prednisone {u} (Compound) resembles {v} (Compound) Triamcinolone
Cyclosporine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Triamcinolone
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Triamcinolone (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Triamcinolone (Compound)
Cyclosporine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Triamcinolone (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Triamcinolone (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Triamcinolone (Compound)
Cyclosporine (Compound) upregulates RAP1GAP (Gene) and RAP1GAP (Gene) is downregulated by Triamcinolone (Compound)
Cyclosporine (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Triamcinolone (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Prednisone (Compound) and Prednisone (Compound) resembles Triamcinolone (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prednisone (Compound) and Prednisone (Compound) resembles Triamcinolone (Compound)
Cyclosporine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Triamcinolone (Compound)