DDInter419 DDInter1938
Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine receptors results in fewer extrapyramidal side effects, especially tardive dyskinesia. However, its promiscuity toward the muscarinic and adrenergic receptors can result in other side effects, notably gastrointestinal hypomotility and orthostatic hypotension. [L905,A215552]. Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis.[A256713,A256718] However, continued evidence of its effectiveness led to clozapine's eventual reintroduction, although
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Clozapine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vincristine
Clozapine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Vincristine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Voacamine
Voacamine {u} (Compound) resembles {v} (Compound) Vincristine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Clozapine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vinorelbine
Vinorelbine {u} (Compound) resembles {v} (Compound) Vincristine
Clozapine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Vinblastine {u} (Compound) resembles {v} (Compound) Vincristine
Clozapine {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) regulates {v} (Gene) TUBA4A
TUBA4A {u} (Gene) is bound by {v} (Compound) Vincristine
Clozapine {u} (Compound) resembles {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Vincristine
Clozapine may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine (Compound) resembles Vincristine (Compound)
Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vincristine (Compound)
Clozapine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Vincristine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine (Compound) resembles Voacamine (Compound) and Voacamine (Compound) resembles Vincristine (Compound)
Clozapine may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine (Compound) resembles Vincristine (Compound)
Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vinorelbine (Compound) and Vinorelbine (Compound) resembles Vincristine (Compound)
Clozapine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Vinblastine (Compound) and Vinblastine (Compound) resembles Vincristine (Compound)
Clozapine (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) regulates TUBA4A (Gene) and TUBA4A (Gene) is bound by Vincristine (Compound)
Clozapine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Vincristine (Compound)