DDInter840 DDInter1662
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Granisetron {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Granisetron {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Granisetron {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Granisetron {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Granisetron {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Granisetron {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Granisetron {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Granisetron {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is regulated by {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Granisetron {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Granisetron {u} (Compound) resembles {v} (Compound) Hyoscyamine
Hyoscyamine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sertraline
Granisetron may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Granisetron (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Sertraline (Compound)
Granisetron (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Granisetron may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Granisetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Granisetron (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Granisetron (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is regulated by FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Sertraline (Compound)
Granisetron (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Granisetron (Compound) resembles Hyoscyamine (Compound) and Hyoscyamine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sertraline (Compound)