DDInter1244 DDInter1960
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Hydromorphone
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxone
Morphine {u} (Compound) resembles {v} (Compound) Hydrocodone
Morphine {u} (Compound) binds {v} (Gene) UGT2B7
Morphine {u} (Compound) palliates {v} (Disease) coronary artery disease
Morphine {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Morphine {u} (Compound) causes {v} (Side Effect) Faecalith
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ephedrine
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Salmon calcitonin
Morphine (Compound) resembles Galantamine (Compound)
Morphine may lead to a major life threatening interaction when taken with Hydromorphone
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone
Morphine (Compound) resembles Hydrocodone (Compound)
Morphine (Compound) binds UGT2B7 (Gene)
Morphine (Compound) palliates coronary artery disease (Disease)
Morphine (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Morphine (Compound) causes Faecalith (Side Effect)
Morphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine
Morphine may cause a minor interaction that can limit clinical effects when taken with Salmon calcitonin