DDInter1237 DDInter150
Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Moexipril {u} (Compound) resembles {v} (Compound) Ramipril
Ramipril {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Moexipril {u} (Compound) resembles {v} (Compound) Donepezil
Donepezil {u} (Compound) causes {v} (Side Effect) Musculoskeletal discomfort
Musculoskeletal discomfort {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Moexipril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Azathioprine
Moexipril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Moexipril {u} (Compound) binds {v} (Gene) SLC15A2
SLC15A2 {u} (Gene) is associated with {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is treated by {v} (Compound) Azathioprine
Moexipril {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) upregulates {v} (Gene) GSTA2
GSTA2 {u} (Gene) is bound by {v} (Compound) Azathioprine
Moexipril {u} (Compound) downregulates {v} (Gene) RNF167
RNF167 {u} (Gene) regulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Moexipril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Aluminum hydroxide {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Moexipril {u} (Compound) downregulates {v} (Gene) RNF167
RNF167 {u} (Gene) regulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Moexipril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Methotrexate {u} (Compound) treats {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Azathioprine
Moexipril (Compound) resembles Ramipril (Compound) and Ramipril (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Azathioprine (Compound)
Moexipril (Compound) resembles Donepezil (Compound) and Donepezil (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Azathioprine (Compound)
Moexipril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Azathioprine (Compound)
Moexipril (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)
Moexipril (Compound) binds SLC15A2 (Gene) and SLC15A2 (Gene) is associated with multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Azathioprine (Compound)
Moexipril (Compound) treats hypertension (Disease) and hypertension (Disease) upregulates GSTA2 (Gene) and GSTA2 (Gene) is bound by Azathioprine (Compound)
Moexipril (Compound) downregulates RNF167 (Gene) and RNF167 (Gene) regulates RRP1B (Gene) and RRP1B (Gene) is downregulated by Azathioprine (Compound)
Moexipril may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide and Aluminum hydroxide (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Azathioprine (Compound)
Moexipril (Compound) downregulates RNF167 (Gene) and RNF167 (Gene) regulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate (Compound) treats systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Azathioprine (Compound)