DDInter458 DDInter20
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer . Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others . Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
Cyclosporine {u} (Compound) upregulates {v} (Gene) HSPA5
HSPA5 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is palliated by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) HSPA5
HSPA5 {u} (Gene) interacts with {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) TP53
TP53 {u} (Gene) interacts with {v} (Gene) HSPA5
HSPA5 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Acetylsalicylic acid
Cyclosporine (Compound) upregulates HSPA5 (Gene) and HSPA5 (Gene) is bound by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is palliated by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) upregulates HSPA5 (Gene) and HSPA5 (Gene) interacts with NFKBIA (Gene) and NFKBIA (Gene) is bound by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Salicylic acid (Compound) and Salicylic acid (Compound) resembles Acetylsalicylic acid (Compound)
Cyclosporine (Compound) upregulates TP53 (Gene) and TP53 (Gene) interacts with HSPA5 (Gene) and HSPA5 (Gene) is bound by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Acetylsalicylic acid (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Salsalate (Compound) and Salsalate (Compound) resembles Acetylsalicylic acid (Compound)