DDInter1707 DDInter1376
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Spironolactone {u} (Compound) resembles {v} (Compound) Dydrogesterone
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Spironolactone {u} (Compound) treats {v} (Disease) dilated cardiomyopathy
Spironolactone {u} (Compound) binds {v} (Gene) PGR
Spironolactone {u} (Compound) upregulates {v} (Gene) WIF1
Spironolactone {u} (Compound) is included by {v} (Pharmacologic Class) Aldosterone Antagonists
Spironolactone {u} (Compound) downregulates {v} (Gene) GNAS
Spironolactone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Spironolactone (Compound) resembles Testosterone (Compound)
Spironolactone (Compound) resembles Dydrogesterone (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Spironolactone (Compound) treats dilated cardiomyopathy (Disease)
Spironolactone (Compound) binds PGR (Gene)
Spironolactone (Compound) upregulates WIF1 (Gene)
Spironolactone (Compound) is included by Aldosterone Antagonists (Pharmacologic Class)
Spironolactone (Compound) downregulates GNAS (Gene)
Spironolactone (Compound) causes Feeling abnormal (Side Effect)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin