DDInter537 DDInter856
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin]. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Diclofenac {u} (Compound) resembles {v} (Compound) Clonidine
Diclofenac {u} (Compound) resembles {v} (Compound) Nepafenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Diclofenac {u} (Compound) binds {v} (Gene) ALOX5
Diclofenac {u} (Compound) palliates {v} (Disease) systemic scleroderma
Diclofenac {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
Diclofenac {u} (Compound) causes {v} (Side Effect) Corneal disorder
Diclofenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Colestipol
Diclofenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cholestyramine
Diclofenac (Compound) resembles Clonidine (Compound)
Diclofenac (Compound) resembles Nepafenac (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac
Diclofenac (Compound) binds ALOX5 (Gene)
Diclofenac (Compound) palliates systemic scleroderma (Disease)
Diclofenac (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Diclofenac (Compound) downregulates PUF60 (Gene)
Diclofenac (Compound) causes Corneal disorder (Side Effect)
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Colestipol
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Cholestyramine