DDInter1423 DDInter704
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Pentobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentobarbital {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Pentobarbital {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Pentobarbital {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Everolimus
Pentobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentobarbital {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentobarbital {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Pentobarbital {u} (Compound) downregulates {v} (Gene) CDK4
CDK4 {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentobarbital {u} (Compound) downregulates {v} (Gene) PSMB8
PSMB8 {u} (Gene) is downregulated by {v} (Compound) Tacrolimus
Tacrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Pentobarbital {u} (Compound) downregulates {v} (Gene) STAMBP
STAMBP {u} (Gene) is regulated by {v} (Gene) USP20
USP20 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound)
Pentobarbital (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Everolimus (Compound)
Pentobarbital (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Everolimus (Compound)
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Pentobarbital (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Everolimus (Compound)
Pentobarbital (Compound) downregulates CDK4 (Gene) and CDK4 (Gene) is downregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Everolimus (Compound)
Pentobarbital (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is downregulated by Tacrolimus (Compound) and Tacrolimus (Compound) resembles Everolimus (Compound)
Pentobarbital (Compound) downregulates STAMBP (Gene) and STAMBP (Gene) is regulated by USP20 (Gene) and USP20 (Gene) is upregulated by Everolimus (Compound)