DDInter1639 DDInter1875
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Trimetrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Trimethoprim
Trimethoprim {u} (Compound) resembles {v} (Compound) Trimetrexate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimetrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trimetrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimetrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimetrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Zidovudine
Zidovudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimetrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Radium Ra 223 dichloride
Radium Ra 223 dichloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimetrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Trimetrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is downregulated by {v} (Compound) Fluconazole
Fluconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trimetrexate
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Trimetrexate (Compound)
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Trimethoprim (Compound) and Trimethoprim (Compound) resembles Trimetrexate (Compound)
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is upregulated by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Sapropterin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Trimetrexate
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Sapropterin (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Zidovudine (Compound) and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Sapropterin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Radium Ra 223 dichloride (Compound) and Radium Ra 223 dichloride may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Sapropterin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Trimetrexate
Sapropterin (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is downregulated by Fluconazole (Compound) and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Trimetrexate