DDInter1867 DDInter154
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) downregulates {v} (Gene) DERA
DERA {u} (Gene) is downregulated by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Azelastine
Triflupromazine {u} (Compound) downregulates {v} (Gene) DERA
DERA {u} (Gene) is regulated by {v} (Gene) RPP38
RPP38 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) downregulates {v} (Gene) NME1
NME1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Compound) Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Triflupromazine {u} (Compound) resembles {v} (Compound) Pipotiazine
Pipotiazine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) PLCB3
PLCB3 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) NME1
NME1 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Triflupromazine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) regulates {v} (Gene) DERA
DERA {u} (Gene) is downregulated by {v} (Compound) Azelastine
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Azelastine (Compound)
Triflupromazine (Compound) downregulates DERA (Gene) and DERA (Gene) is downregulated by Azelastine (Compound)
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clozapine (Compound) and Clozapine (Compound) resembles Azelastine (Compound)
Triflupromazine (Compound) downregulates DERA (Gene) and DERA (Gene) is regulated by RPP38 (Gene) and RPP38 (Gene) is upregulated by Azelastine (Compound)
Triflupromazine (Compound) downregulates NME1 (Gene) and NME1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Azelastine (Compound)
Triflupromazine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by Clemastine (Compound) and Clemastine (Compound) resembles Azelastine (Compound)
Triflupromazine (Compound) resembles Pipotiazine (Compound) and Pipotiazine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Azelastine (Compound)
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates PLCB3 (Gene) and PLCB3 (Gene) is upregulated by Azelastine (Compound)
Triflupromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by NME1 (Gene) and NME1 (Gene) is downregulated by Azelastine (Compound)
Triflupromazine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) regulates DERA (Gene) and DERA (Gene) is downregulated by Azelastine (Compound)