DDInter466 DDInter150
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Dactinomycin {u} (Compound) upregulates {v} (Gene) TPMT
TPMT {u} (Gene) is bound by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) upregulates {v} (Gene) ADAT1
ADAT1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) upregulates {v} (Gene) TPMT
TPMT {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dactinomycin {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Dactinomycin (Compound) upregulates TPMT (Gene) and TPMT (Gene) is bound by Azathioprine (Compound)
Dactinomycin (Compound) upregulates ADAT1 (Gene) and ADAT1 (Gene) is upregulated by Azathioprine (Compound)
Dactinomycin (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is upregulated by Azathioprine (Compound)
Dactinomycin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Dactinomycin (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Dactinomycin (Compound) upregulates TPMT (Gene) and TPMT (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)
Dactinomycin (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Dactinomycin (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Dactinomycin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Dactinomycin (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)