DDInter987 DDInter1376
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and cardiac output, without vasoconstriction.[A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline]. Isoprenaline was granted FDA approval on 19 February 1948.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylephrine
Isoprenaline {u} (Compound) resembles {v} (Compound) Hexoprenaline
Isoprenaline {u} (Compound) resembles {v} (Compound) Isoetharine
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levonordefrin
Isoprenaline {u} (Compound) treats {v} (Disease) asthma
Isoprenaline {u} (Compound) binds {v} (Gene) PIK3R2
Isoprenaline {u} (Compound) upregulates {v} (Gene) DHX29
Isoprenaline {u} (Compound) downregulates {v} (Gene) COG2
Isoprenaline {u} (Compound) causes {v} (Side Effect) Flushing
Isoprenaline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ciclesonide
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine
Isoprenaline (Compound) resembles Hexoprenaline (Compound)
Isoprenaline (Compound) resembles Isoetharine (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin
Isoprenaline (Compound) treats asthma (Disease)
Isoprenaline (Compound) binds PIK3R2 (Gene)
Isoprenaline (Compound) upregulates DHX29 (Gene)
Isoprenaline (Compound) downregulates COG2 (Gene)
Isoprenaline (Compound) causes Flushing (Side Effect)
Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Ciclesonide