DDInter1729 DDInter246
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product with [formoterol].
Sulindac {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Budesonide
Sulindac {u} (Compound) causes {v} (Side Effect) Sweating increased
Sweating increased {u} (Side Effect) is caused by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Budesonide
Sulindac {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Orciprenaline
Orciprenaline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Budesonide
Sulindac {u} (Compound) causes {v} (Side Effect) Leukocytoclastic vasculitis
Leukocytoclastic vasculitis {u} (Side Effect) is caused by {v} (Compound) Dronedarone
Dronedarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Nifedipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Sulindac {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Reserpine
Reserpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clobetasol propionate
Clobetasol propionate {u} (Compound) resembles {v} (Compound) Budesonide
Sulindac {u} (Compound) binds {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) regulates {v} (Gene) SQRDL
SQRDL {u} (Gene) is upregulated by {v} (Compound) Budesonide
Sulindac {u} (Compound) binds {v} (Gene) PTGDR2
PTGDR2 {u} (Gene) is associated with {v} (Disease) asthma
asthma {u} (Disease) is treated by {v} (Compound) Budesonide
Sulindac {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) interacts with {v} (Gene) CDC45
CDC45 {u} (Gene) is downregulated by {v} (Compound) Budesonide
Sulindac (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Budesonide (Compound)
Sulindac (Compound) causes Sweating increased (Side Effect) and Sweating increased (Side Effect) is caused by Betamethasone (Compound) and Betamethasone (Compound) resembles Budesonide (Compound)
Sulindac (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Orciprenaline (Compound) and Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Budesonide
Sulindac (Compound) causes Leukocytoclastic vasculitis (Side Effect) and Leukocytoclastic vasculitis (Side Effect) is caused by Dronedarone (Compound) and Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound) and Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Sulindac (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Reserpine (Compound) and Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clobetasol propionate (Compound) and Clobetasol propionate (Compound) resembles Budesonide (Compound)
Sulindac (Compound) binds AKR1B1 (Gene) and AKR1B1 (Gene) regulates SQRDL (Gene) and SQRDL (Gene) is upregulated by Budesonide (Compound)
Sulindac (Compound) binds PTGDR2 (Gene) and PTGDR2 (Gene) is associated with asthma (Disease) and asthma (Disease) is treated by Budesonide (Compound)
Sulindac (Compound) binds ALB (Gene) and ALB (Gene) interacts with CDC45 (Gene) and CDC45 (Gene) is downregulated by Budesonide (Compound)