DDInter598 DDInter557
Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Doxycycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Doxycycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Ergoloid mesylate
Ergoloid mesylate {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline {u} (Compound) resembles {v} (Compound) Demeclocycline
Demeclocycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ergoloid mesylate
Ergoloid mesylate {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tetracycline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Doxycycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dihydroergotamine
Doxycycline {u} (Compound) resembles {v} (Compound) Tetracycline
Tetracycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline {u} (Compound) resembles {v} (Compound) Minocycline
Minocycline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergotamine
Ergotamine {u} (Compound) resembles {v} (Compound) Dihydroergotamine
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dihydroergotamine (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Ergoloid mesylate (Compound) and Ergoloid mesylate (Compound) resembles Dihydroergotamine (Compound)
Doxycycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ergoloid mesylate (Compound) and Ergoloid mesylate (Compound) resembles Dihydroergotamine (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) resembles Dihydroergotamine (Compound)
Doxycycline (Compound) resembles Tetracycline (Compound) and Tetracycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dihydroergotamine (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dihydroergotamine (Compound)
Doxycycline (Compound) resembles Tetracycline (Compound) and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Dihydroergotamine (Compound)
Doxycycline (Compound) resembles Minocycline (Compound) and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Dihydroergotamine (Compound)