DDInter535 DDInter1274
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Diazoxide {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Diazoxide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Diazoxide {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Nefazodone
Diazoxide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Hydroxyzine
Hydroxyzine {u} (Compound) resembles {v} (Compound) Nefazodone
Diazoxide {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Nefazodone
Diazoxide {u} (Compound) causes {v} (Side Effect) Ageusia
Ageusia {u} (Side Effect) is caused by {v} (Compound) Cetirizine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nefazodone
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Diazoxide {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Nefazodone
Diazoxide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Perphenazine
Perphenazine {u} (Compound) resembles {v} (Compound) Nefazodone
Diazoxide {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) interacts with {v} (Gene) IKBKE
IKBKE {u} (Gene) is upregulated by {v} (Compound) Nefazodone
Diazoxide (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Nefazodone (Compound)
Diazoxide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nefazodone (Compound)
Diazoxide (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Quetiapine (Compound) and Quetiapine (Compound) resembles Nefazodone (Compound)
Diazoxide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Hydroxyzine (Compound) and Hydroxyzine (Compound) resembles Nefazodone (Compound)
Diazoxide (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Nefazodone (Compound)
Diazoxide (Compound) causes Ageusia (Side Effect) and Ageusia (Side Effect) is caused by Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Nefazodone (Compound)
Diazoxide (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Nefazodone (Compound)
Diazoxide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Perphenazine (Compound) and Perphenazine (Compound) resembles Nefazodone (Compound)
Diazoxide (Compound) downregulates CYCS (Gene) and CYCS (Gene) interacts with IKBKE (Gene) and IKBKE (Gene) is upregulated by Nefazodone (Compound)