DDInter1158 DDInter1831
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
Mesalazine {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Tolmetin
Mesalazine {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is downregulated by {v} (Compound) Tolmetin
Mesalazine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Tolmetin
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolmetin
Mesalazine {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is associated with {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Tolmetin
Mesalazine {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Zolpidem
Zolpidem {u} (Compound) resembles {v} (Compound) Tolmetin
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Lumiracoxib
Lumiracoxib {u} (Compound) resembles {v} (Compound) Tolmetin
Mesalazine {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is downregulated by {v} (Compound) Suprofen
Suprofen {u} (Compound) resembles {v} (Compound) Tolmetin
Mesalazine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Zolpidem
Zolpidem {u} (Compound) resembles {v} (Compound) Tolmetin
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} (Compound) resembles {v} (Compound) Tolmetin
Mesalazine (Compound) binds MPO (Gene) and MPO (Gene) is bound by Tolmetin (Compound)
Mesalazine (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is downregulated by Tolmetin (Compound)
Mesalazine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Tolmetin (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin
Mesalazine (Compound) binds MPO (Gene) and MPO (Gene) is associated with rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Tolmetin (Compound)
Mesalazine (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Zolpidem (Compound) and Zolpidem (Compound) resembles Tolmetin (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Lumiracoxib (Compound) and Lumiracoxib (Compound) resembles Tolmetin (Compound)
Mesalazine (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is downregulated by Suprofen (Compound) and Suprofen (Compound) resembles Tolmetin (Compound)
Mesalazine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Zolpidem (Compound) and Zolpidem (Compound) resembles Tolmetin (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)