DDInter1174 DDInter576
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Methotrexate {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) upregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) binds {v} (Gene) TYMS
TYMS {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) upregulates {v} (Gene) MOK
MOK {u} (Gene) interacts with {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) regulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Methotrexate {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) interacts with {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Methotrexate (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Methotrexate (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is upregulated by Disulfiram (Compound)
Methotrexate (Compound) upregulates DDB2 (Gene) and DDB2 (Gene) is downregulated by Disulfiram (Compound)
Methotrexate (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Methotrexate (Compound) binds TYMS (Gene) and TYMS (Gene) is downregulated by Disulfiram (Compound)
Methotrexate (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Methotrexate (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Methotrexate (Compound) upregulates MOK (Gene) and MOK (Gene) interacts with MYC (Gene) and MYC (Gene) is upregulated by Disulfiram (Compound)
Methotrexate (Compound) upregulates RELB (Gene) and RELB (Gene) regulates NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Methotrexate (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) interacts with NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)