DDInter336 DDInter698
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Celecoxib {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) DHX29
DHX29 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) regulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is associated with {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is treated by {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) resembles {v} (Disease) Paget's disease of bone
Paget's disease of bone {u} (Disease) is treated by {v} (Compound) Etidronic acid
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) resembles {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is treated by {v} (Compound) Etidronic acid
Celecoxib (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Etidronic acid (Compound)
Celecoxib (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Celecoxib (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by DHX29 (Gene) and DHX29 (Gene) is upregulated by Etidronic acid (Compound)
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) regulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Etidronic acid (Compound)
Celecoxib (Compound) binds CA2 (Gene) and CA2 (Gene) is associated with osteoporosis (Disease) and osteoporosis (Disease) is treated by Etidronic acid (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) resembles Paget's disease of bone (Disease) and Paget's disease of bone (Disease) is treated by Etidronic acid (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) resembles osteoporosis (Disease) and osteoporosis (Disease) is treated by Etidronic acid (Compound)