DDInter112 DDInter1397
Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Aprepitant {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) binds {v} (Gene) TACR1
TACR1 {u} (Gene) is associated with {v} (Disease) bipolar disorder
bipolar disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) resembles {v} (Compound) Fosaprepitant
Fosaprepitant {u} (Compound) binds {v} (Gene) TACR1
TACR1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) resembles {v} (Compound) Fosaprepitant
Fosaprepitant {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) PER1
PER1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) and {u} (Diease) associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Aprepitant {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Aprepitant (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Aprepitant (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Aprepitant (Compound) binds TACR1 (Gene) and TACR1 (Gene) is associated with bipolar disorder (Disease) and bipolar disorder (Disease) is palliated by Paroxetine (Compound)
Aprepitant (Compound) resembles Fosaprepitant (Compound) and Fosaprepitant (Compound) binds TACR1 (Gene) and TACR1 (Gene) is bound by Paroxetine (Compound)
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Paroxetine (Compound)
Aprepitant (Compound) resembles Fosaprepitant (Compound) and Fosaprepitant (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Aprepitant (Compound) palliates colon cancer (Disease) and colon cancer (Disease) downregulates PER1 (Gene) and PER1 (Gene) is upregulated by Paroxetine (Compound)
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Paroxetine (Compound)
Aprepitant (Compound) palliates colon cancer (Disease) and colon cancer (Disease) downregulates ABCB1 (Gene) and colon cancer (Diease) associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Paroxetine (Compound)