DDInter1868 DDInter1676
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and 2. The combination product of trifluridine with tipiracil marketed as Lonsurf has been approved in Japan, the United States, and the European Union for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In the anticancer therapy, trifluridine acts as a thymidine-based nucleoside metabolic inhibitor that gets
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Trifluridine {u} (Compound) resembles {v} (Compound) Telbivudine
Trifluridine {u} (Compound) resembles {v} (Compound) Pentostatin
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Trifluridine {u} (Compound) binds {v} (Gene) SLC22A6
Trifluridine {u} (Compound) upregulates {v} (Gene) CRIP1
Trifluridine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Trifluridine {u} (Compound) downregulates {v} (Gene) UBQLN2
Trifluridine {u} (Compound) causes {v} (Side Effect) Keratitis sicca
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegfilgrastim
Trifluridine {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Trifluridine (Compound) resembles Telbivudine (Compound)
Trifluridine (Compound) resembles Pentostatin (Compound)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Trifluridine (Compound) binds SLC22A6 (Gene)
Trifluridine (Compound) upregulates CRIP1 (Gene)
Trifluridine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Trifluridine (Compound) downregulates UBQLN2 (Gene)
Trifluridine (Compound) causes Keratitis sicca (Side Effect)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim
Trifluridine may lead to a major life threatening interaction when taken with Clozapine