DDInter900 DDInter698
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID. On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Ibuprofen {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is regulated by {v} (Gene) DHX29
DHX29 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Risedronic acid and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Ibuprofen (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Etidronic acid (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Risedronic acid and Risedronic acid (Compound) resembles Ibandronate (Compound) and Ibandronate (Compound) resembles Etidronic acid (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Ibuprofen (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Ibuprofen (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid and Pamidronic acid (Compound) resembles Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Ibuprofen (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Ibuprofen (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Ibuprofen (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is regulated by DHX29 (Gene) and DHX29 (Gene) is upregulated by Etidronic acid (Compound)