DDInter479 DDInter458
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Darbepoetin alfa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trandolapril
Trandolapril {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Perindopril
Perindopril {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Perindopril
Perindopril {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Carfilzomib {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Carfilzomib {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enalapril
Enalapril {u} (Compound) upregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Darbepoetin alfa {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Trandolapril and Trandolapril (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Cyclosporine (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Perindopril and Perindopril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cyclosporine (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Perindopril and Perindopril (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Cyclosporine (Compound)
Darbepoetin alfa may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cyclosporine (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Cyclosporine (Compound)
Darbepoetin alfa may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Cyclosporine (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Cyclosporine (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Enalapril and Enalapril (Compound) upregulates CRYZ (Gene) and CRYZ (Gene) is downregulated by Cyclosporine (Compound)
Darbepoetin alfa may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Cyclosporine (Compound)
Darbepoetin alfa may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Cyclosporine (Compound)