DDInter810 DDInter1233
Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Gefitinib {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Mitotane
Gefitinib {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Gefitinib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Gefitinib {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Gefitinib {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Gefitinib {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) is regulated by {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Gefitinib {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Gefitinib {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) regulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Gefitinib {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) regulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Mitotane
Gefitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Gefitinib (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Mitotane (Compound)
Gefitinib (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Gefitinib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Gefitinib (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Gefitinib (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Gefitinib (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is regulated by ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Mitotane (Compound)
Gefitinib (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Mitotane (Compound)
Gefitinib (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) regulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Mitotane (Compound)
Gefitinib (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) regulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Mitotane (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Mitotane (Compound)