DDInter181 DDInter1008
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine. Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Benzatropine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) resembles {v} (Compound) Atomoxetine
Atomoxetine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) resembles {v} (Compound) Eprazinone
Eprazinone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Benzatropine {u} (Compound) resembles {v} (Compound) Benzphetamine
Benzphetamine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Benzatropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atropine
Atropine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Benzatropine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Mepenzolate {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Benzatropine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ketoconazole (Compound)
Benzatropine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Ketoconazole (Compound)
Benzatropine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Benzatropine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Benzatropine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Benzatropine (Compound) resembles Atomoxetine (Compound) and Atomoxetine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ketoconazole (Compound)
Benzatropine (Compound) resembles Eprazinone (Compound) and Eprazinone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Ketoconazole (Compound)
Benzatropine (Compound) resembles Benzphetamine (Compound) and Benzphetamine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Ketoconazole (Compound)
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ketoconazole (Compound)
Benzatropine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Ketoconazole (Compound)