DDInter298 DDInter894
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, hydroxyurea is used sparingly in clinical settings, largely due to lack of knowledge and adherence, the need for therapeutic monitoring, and serious side effects of secondary cancer and birth defects.
Carboplatin {u} (Compound) treats {v} (Disease) brain cancer
brain cancer {u} (Disease) is treated by {v} (Compound) Hydroxyurea
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Hydroxyurea
Carboplatin {u} (Compound) treats {v} (Disease) brain cancer
brain cancer {u} (Disease) is treated by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxyurea
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Gatifloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxyurea
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Trovafloxacin
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hydroxyurea
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) resembles {v} (Disease) head and neck cancer
head and neck cancer {u} (Disease) is treated by {v} (Compound) Hydroxyurea
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Pentostatin
Pentostatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxyurea
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxyurea
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxyurea
Carboplatin {u} (Compound) treats {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is associated with {v} (Gene) RRM2
RRM2 {u} (Gene) is bound by {v} (Compound) Hydroxyurea
Carboplatin (Compound) treats brain cancer (Disease) and brain cancer (Disease) is treated by Hydroxyurea (Compound)
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Hydroxyurea (Compound)
Carboplatin (Compound) treats brain cancer (Disease) and brain cancer (Disease) is treated by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Gatifloxacin (Compound) and Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Hydroxyurea
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Trovafloxacin (Compound) and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Hydroxyurea
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) resembles head and neck cancer (Disease) and head and neck cancer (Disease) is treated by Hydroxyurea (Compound)
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Pentostatin (Compound) and Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea
Carboplatin (Compound) treats urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is associated with RRM2 (Gene) and RRM2 (Gene) is bound by Hydroxyurea (Compound)