DDInter99 DDInter856
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Anistreplase {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chamomile
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etodolac
Anistreplase {u} may lead to a major life threatening interaction when taken with {v} Tirofiban
Anistreplase {u} may lead to a major life threatening interaction when taken with {v} Lepirudin
Anistreplase may cause a minor interaction that can limit clinical effects when taken with Chamomile
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Anistreplase may lead to a major life threatening interaction when taken with Tirofiban
Anistreplase may lead to a major life threatening interaction when taken with Lepirudin