DDInter458 DDInter1285
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Nevirapine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Nevirapine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nevirapine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nevirapine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nevirapine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Bullous eruption
Bullous eruption {u} (Side Effect) is caused by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nevirapine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypertriglyceridaemia
Hypertriglyceridaemia {u} (Side Effect) is caused by {v} (Compound) Bexarotene
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nevirapine
Cyclosporine {u} (Compound) binds {v} (Gene) PPP3CA
PPP3CA {u} (Gene) is downregulated by {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) is treated by {v} (Compound) Nevirapine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nevirapine
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) is treated by {v} (Compound) Nevirapine
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Nevirapine (Compound)
Cyclosporine (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Nevirapine (Compound)
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Nevirapine
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Nevirapine
Cyclosporine (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Nevirapine
Cyclosporine (Compound) causes Bullous eruption (Side Effect) and Bullous eruption (Side Effect) is caused by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Nevirapine
Cyclosporine (Compound) causes Hypertriglyceridaemia (Side Effect) and Hypertriglyceridaemia (Side Effect) is caused by Bexarotene (Compound) and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Nevirapine
Cyclosporine (Compound) binds PPP3CA (Gene) and PPP3CA (Gene) is downregulated by acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) is treated by Nevirapine (Compound)
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cisapride (Compound) and Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Nevirapine
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) is treated by Nevirapine (Compound)