DDInter890 DDInter154
Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound. Even though hydromorphone does not present a 6-hydroxyl group, it is categorized under the family of phenanthrenes and it is considered a chemical under the schedule II (medical purposes with high addiction potential). The first reported approved product containing hydromorphone in the form of hydromorphone hydrochloride was developed by Fresenius Kabi USA and FDA approved in 1984.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Hydromorphone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Azelastine
Hydromorphone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Hydromorphone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Azelastine
Hydromorphone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Buclizine
Buclizine {u} (Compound) resembles {v} (Compound) Azelastine
Hydromorphone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Cloperastine
Cloperastine {u} (Compound) resembles {v} (Compound) Azelastine
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Azelastine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Hydromorphone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Azelastine (Compound)
Hydromorphone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Hydromorphone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Clozapine (Compound) and Clozapine (Compound) resembles Azelastine (Compound)
Hydromorphone (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Buclizine (Compound) and Buclizine (Compound) resembles Azelastine (Compound)
Hydromorphone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Azelastine (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Azelastine (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Azelastine (Compound)