DDInter248 DDInter569
Bumetanide is a sulfamyl diuretic.
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed for use within many non-prescription over-the-counter sleep aids and cough-and-cold medications that have been marketed for "night time" use [L5263, L5281, L5287]. Diphenhydramine is also used in combination with as the anti-nausea drug where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system . Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid . As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
Bumetanide {u} (Compound) resembles {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Diphenhydramine
Bumetanide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Diphenhydramine
Bumetanide {u} (Compound) resembles {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Tropicamide
Tropicamide {u} (Compound) resembles {v} (Compound) Diphenhydramine
Bumetanide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Diphenhydramine
Bumetanide {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Bepridil
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Bumetanide {u} (Compound) resembles {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Bumetanide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Bumetanide {u} (Compound) causes {v} (Side Effect) Fatigue
Fatigue {u} (Side Effect) is caused by {v} (Compound) Tropicamide
Tropicamide {u} (Compound) resembles {v} (Compound) Diphenhydramine
Bumetanide {u} (Compound) resembles {v} (Compound) Furosemide
Furosemide {u} (Compound) binds {v} (Gene) SLC22A5
SLC22A5 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Bumetanide {u} (Compound) resembles {v} (Compound) Indapamide
Indapamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Diphenhydramine
Bumetanide (Compound) resembles Fenoprofen (Compound) and Fenoprofen (Compound) resembles Diphenhydramine (Compound)
Bumetanide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Diphenhydramine (Compound)
Bumetanide (Compound) resembles Fenoprofen (Compound) and Fenoprofen (Compound) resembles Tropicamide (Compound) and Tropicamide (Compound) resembles Diphenhydramine (Compound)
Bumetanide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Toremifene (Compound) and Toremifene (Compound) resembles Diphenhydramine (Compound)
Bumetanide (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Bepridil (Compound) and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Bumetanide (Compound) resembles Indapamide (Compound) and Indapamide (Compound) resembles Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Bumetanide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Doxylamine (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Bumetanide (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Tropicamide (Compound) and Tropicamide (Compound) resembles Diphenhydramine (Compound)
Bumetanide (Compound) resembles Furosemide (Compound) and Furosemide (Compound) binds SLC22A5 (Gene) and SLC22A5 (Gene) is bound by Diphenhydramine (Compound)
Bumetanide (Compound) resembles Indapamide (Compound) and Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremifene (Compound) resembles Diphenhydramine (Compound)