DDInter1120 DDInter1822
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Aminoglycosides, many of which are derived directly from _Streptomyces_ spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics.[A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.[L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.[A232294, A232349, L32739, L32749] Tobramycin was approved by the FDA in 1975 and is currently available in a variety of forms for administration by inhalation, injection, and external application to the eye (ophthalmic).[L32739, L32744, L32749]
Magnesium sulfate {u} may lead to a major life threatening interaction when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lactulose
Lactulose {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} (Compound) causes {v} (Side Effect) Respiratory depression
Respiratory depression {u} (Side Effect) is caused by {v} (Compound) Tobramycin
Magnesium sulfate {u} may lead to a major life threatening interaction when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Paromomycin
Paromomycin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} may lead to a major life threatening interaction when taken with {v} Gentamicin
Gentamicin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} may lead to a major life threatening interaction when taken with {v} Neomycin
Neomycin {u} (Compound) resembles {v} (Compound) Paromomycin
Paromomycin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lactulose
Lactulose {u} (Compound) resembles {v} (Compound) Paromomycin
Paromomycin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} (Compound) causes {v} (Side Effect) Respiratory depression
Respiratory depression {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Gentamicin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} may lead to a major life threatening interaction when taken with {v} Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Gentamicin
Gentamicin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate {u} may lead to a major life threatening interaction when taken with {v} Gentamicin
Gentamicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Neomycin {u} (Compound) resembles {v} (Compound) Tobramycin
Magnesium sulfate may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose (Compound) resembles Tobramycin (Compound)
Magnesium sulfate (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Tobramycin (Compound)
Magnesium sulfate may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin (Compound) resembles Paromomycin (Compound) and Paromomycin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin (Compound) resembles Kanamycin (Compound) and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate may lead to a major life threatening interaction when taken with Neomycin and Neomycin (Compound) resembles Paromomycin (Compound) and Paromomycin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose (Compound) resembles Paromomycin (Compound) and Paromomycin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate (Compound) causes Respiratory depression (Side Effect) and Respiratory depression (Side Effect) is caused by Gentamicin (Compound) and Gentamicin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin (Compound) resembles Gentamicin (Compound) and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin and Gentamicin (Compound) resembles Tobramycin (Compound)
Magnesium sulfate may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin (Compound) resembles Tobramycin (Compound)