DDInter1042 DDInter1610
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Rivastigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Rivastigmine {u} (Compound) resembles {v} (Compound) Tapentadol
Rivastigmine {u} (Compound) treats {v} (Disease) Alzheimer's disease
Rivastigmine {u} (Compound) binds {v} (Gene) ACHE
Rivastigmine {u} (Compound) upregulates {v} (Gene) GHR
Rivastigmine {u} (Compound) palliates {v} (Disease) Parkinson's disease
Rivastigmine {u} (Compound) downregulates {v} (Gene) CCNH
Rivastigmine {u} (Compound) causes {v} (Side Effect) Cutaneous hypersensitivity
Rivastigmine (Compound) resembles Pyridostigmine (Compound)
Rivastigmine (Compound) resembles Tapentadol (Compound)
Rivastigmine (Compound) treats Alzheimer's disease (Disease)
Rivastigmine (Compound) binds ACHE (Gene)
Rivastigmine (Compound) upregulates GHR (Gene)
Rivastigmine (Compound) palliates Parkinson's disease (Disease)
Rivastigmine (Compound) downregulates CCNH (Gene)
Rivastigmine (Compound) causes Cutaneous hypersensitivity (Side Effect)