DDInter1662 DDInter1492
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Sertraline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ponatinib
Sertraline {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Sertraline {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Sertraline {u} (Compound) causes {v} (Side Effect) Migraine
Migraine {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Sertraline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ponatinib
Sertraline {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ponatinib
Sertraline {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is regulated by {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Ponatinib
Sertraline {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ponatinib
Sertraline {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is regulated by {v} (Gene) ABCF1
ABCF1 {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Sertraline {u} (Compound) downregulates {v} (Gene) EED
EED {u} (Gene) regulates {v} (Gene) CHAC1
CHAC1 {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Sertraline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Sertraline (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Ponatinib (Compound)
Sertraline (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Ponatinib (Compound)
Sertraline (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Ponatinib (Compound)
Sertraline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Sertraline (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Ponatinib (Compound)
Sertraline (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is regulated by ABCG2 (Gene) and ABCG2 (Gene) is bound by Ponatinib (Compound)
Sertraline (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Sertraline (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is regulated by ABCF1 (Gene) and ABCF1 (Gene) is upregulated by Ponatinib (Compound)
Sertraline (Compound) downregulates EED (Gene) and EED (Gene) regulates CHAC1 (Gene) and CHAC1 (Gene) is upregulated by Ponatinib (Compound)