DDInter93 DDInter1397
Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythemia treatments (e.g. [busulfan], [hydroxyurea]) and may be better tolerated.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Anagrelide {u} (Compound) downregulates {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) causes {v} (Side Effect) Amblyopia
Amblyopia {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) downregulates {v} (Gene) EBP
EBP {u} (Gene) is regulated by {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) regulates {v} (Gene) CSTA
CSTA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) upregulates {v} (Gene) HMG20B
HMG20B {u} (Gene) interacts with {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Anagrelide {u} (Compound) upregulates {v} (Gene) HMG20B
HMG20B {u} (Gene) regulates {v} (Gene) CSTA
CSTA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Anagrelide (Compound) downregulates EBP (Gene) and EBP (Gene) is upregulated by Paroxetine (Compound)
Anagrelide (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Paroxetine (Compound)
Anagrelide (Compound) causes Amblyopia (Side Effect) and Amblyopia (Side Effect) is caused by Paroxetine (Compound)
Anagrelide (Compound) downregulates EBP (Gene) and EBP (Gene) is regulated by SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Paroxetine (Compound)
Anagrelide (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) regulates CSTA (Gene) and CSTA (Gene) is upregulated by Paroxetine (Compound)
Anagrelide (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Anagrelide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Paroxetine (Compound)
Anagrelide (Compound) upregulates HMG20B (Gene) and HMG20B (Gene) interacts with HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Paroxetine (Compound)
Anagrelide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Anagrelide (Compound) upregulates HMG20B (Gene) and HMG20B (Gene) regulates CSTA (Gene) and CSTA (Gene) is upregulated by Paroxetine (Compound)