DDInter1055 DDInter672
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class. Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822]
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Escitalopram
Levofloxacin {u} (Compound) causes {v} (Side Effect) Dysmenorrhoea
Dysmenorrhoea {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Levofloxacin {u} (Compound) causes {v} (Side Effect) Dysmenorrhoea
Dysmenorrhoea {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} (Compound) resembles {v} (Compound) Escitalopram
Levofloxacin {u} (Compound) resembles {v} (Compound) Enoxacin
Enoxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Idarubicin
Idarubicin {u} may lead to a major life threatening interaction when taken with {v} Escitalopram
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Miconazole
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Escitalopram
Levofloxacin {u} (Compound) causes {v} (Side Effect) Dysmenorrhoea
Dysmenorrhoea {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Escitalopram
Levofloxacin {u} (Compound) causes {v} (Side Effect) Otitis media
Otitis media {u} (Side Effect) is caused by {v} (Compound) Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Escitalopram
Levofloxacin {u} (Compound) causes {v} (Side Effect) Mania
Mania {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Escitalopram
Levofloxacin {u} (Compound) causes {v} (Side Effect) Tuberculosis
Tuberculosis {u} (Side Effect) is caused by {v} (Compound) Pentamidine
Pentamidine {u} may lead to a major life threatening interaction when taken with {v} Escitalopram
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Levofloxacin (Compound) causes Dysmenorrhoea (Side Effect) and Dysmenorrhoea (Side Effect) is caused by Escitalopram (Compound)
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Levofloxacin (Compound) causes Dysmenorrhoea (Side Effect) and Dysmenorrhoea (Side Effect) is caused by Citalopram (Compound) and Citalopram (Compound) resembles Escitalopram (Compound)
Levofloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cause a minor interaction that can limit clinical effects when taken with Idarubicin and Idarubicin may lead to a major life threatening interaction when taken with Escitalopram
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound) and Miconazole may cause a minor interaction that can limit clinical effects when taken with Escitalopram
Levofloxacin (Compound) causes Dysmenorrhoea (Side Effect) and Dysmenorrhoea (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Escitalopram
Levofloxacin (Compound) causes Otitis media (Side Effect) and Otitis media (Side Effect) is caused by Salbutamol (Compound) and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram
Levofloxacin (Compound) causes Mania (Side Effect) and Mania (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram
Levofloxacin (Compound) causes Tuberculosis (Side Effect) and Tuberculosis (Side Effect) is caused by Pentamidine (Compound) and Pentamidine may lead to a major life threatening interaction when taken with Escitalopram