DDInter68 DDInter832
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Amiloride {u} (Compound) treats {v} (Disease) hypertension
Amiloride {u} (Compound) binds {v} (Gene) SLC22A1
Amiloride {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Amiloride {u} (Compound) causes {v} (Side Effect) Angina pectoris
Amiloride {u} may cause a minor interaction that can limit clinical effects when taken with {v} Doxycycline
Amiloride {u} may cause a minor interaction that can limit clinical effects when taken with {v} Oxytetracycline
Amiloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Danaparoid
Amiloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Amiloride {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Amiloride (Compound) treats hypertension (Disease)
Amiloride (Compound) binds SLC22A1 (Gene)
Amiloride (Compound) is included by Increased Diuresis (Pharmacologic Class)
Amiloride (Compound) causes Angina pectoris (Side Effect)
Amiloride may cause a minor interaction that can limit clinical effects when taken with Doxycycline
Amiloride may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Danaparoid
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Amiloride may lead to a major life threatening interaction when taken with Potassium chloride