DDInter293 DDInter899
Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Carbamazepine {u} (Compound) resembles {v} (Compound) Magnesium salicylate
Carbamazepine {u} (Compound) resembles {v} (Compound) Modafinil
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Carbamazepine {u} (Compound) treats {v} (Disease) epilepsy syndrome
Carbamazepine {u} (Compound) binds {v} (Gene) SCN9A
Carbamazepine {u} (Compound) upregulates {v} (Gene) PLCB3
Carbamazepine {u} (Compound) palliates {v} (Disease) bipolar disorder
Carbamazepine {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 1A2 Inducers
Carbamazepine {u} (Compound) downregulates {v} (Gene) TIMM9
Carbamazepine (Compound) resembles Magnesium salicylate (Compound)
Carbamazepine (Compound) resembles Modafinil (Compound)
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Carbamazepine (Compound) treats epilepsy syndrome (Disease)
Carbamazepine (Compound) binds SCN9A (Gene)
Carbamazepine (Compound) upregulates PLCB3 (Gene)
Carbamazepine (Compound) palliates bipolar disorder (Disease)
Carbamazepine (Compound) is included by Cytochrome P450 1A2 Inducers (Pharmacologic Class)
Carbamazepine (Compound) downregulates TIMM9 (Gene)