DDInter268 DDInter662
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolated for the first time from yeast in 1931 and its structure was elucidated in 1932. Ergocalciferol is considered the first vitamin D analog and is differentiated from [cholecalciferol] by the presence of a double bond between C22 and C23 and the presence of a methyl group at C24. These modifications reduce the affinity of ergocalciferol for the vitamin D binding protein resulting in faster clearance, limits its activation, and alters its catabolism. The first approved product containing ergocalciferol under the FDA records was developed by US Pharm Holdings and was FDA approved in 1941.
Calcitriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may lead to a major life threatening interaction when taken with {v} Ergocalciferol
Calcitriol {u} (Compound) resembles {v} (Compound) Calcipotriol
Calcipotriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Calcitriol {u} (Compound) treats {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is treated by {v} (Compound) Ergocalciferol
Calcitriol {u} (Compound) binds {v} (Gene) CYP24A1
CYP24A1 {u} (Gene) is bound by {v} (Compound) Ergocalciferol
Calcitriol {u} (Compound) causes {v} (Side Effect) Urine output increased
Urine output increased {u} (Side Effect) is caused by {v} (Compound) Ergocalciferol
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Ergocalciferol
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} (Compound) resembles {v} (Compound) Calcipotriol
Calcipotriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Calcitriol {u} (Compound) resembles {v} (Compound) Calcipotriol
Calcipotriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may lead to a major life threatening interaction when taken with {v} Ergocalciferol
Calcitriol {u} (Compound) treats {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is associated with {v} (Gene) CYP27A1
CYP27A1 {u} (Gene) is bound by {v} (Compound) Ergocalciferol
Calcitriol (Compound) resembles Ergocalciferol (Compound)
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may lead to a major life threatening interaction when taken with Ergocalciferol
Calcitriol (Compound) resembles Calcipotriol (Compound) and Calcipotriol (Compound) resembles Ergocalciferol (Compound)
Calcitriol (Compound) treats osteoporosis (Disease) and osteoporosis (Disease) is treated by Ergocalciferol (Compound)
Calcitriol (Compound) binds CYP24A1 (Gene) and CYP24A1 (Gene) is bound by Ergocalciferol (Compound)
Calcitriol (Compound) causes Urine output increased (Side Effect) and Urine output increased (Side Effect) is caused by Ergocalciferol (Compound)
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol (Compound) resembles Ergocalciferol (Compound) and Cholecalciferol may lead to a major life threatening interaction when taken with Ergocalciferol
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol (Compound) resembles Calcipotriol (Compound) and Calcipotriol (Compound) resembles Ergocalciferol (Compound)
Calcitriol (Compound) resembles Calcipotriol (Compound) and Calcipotriol (Compound) resembles Calcifediol (Compound) and Calcifediol may lead to a major life threatening interaction when taken with Ergocalciferol
Calcitriol (Compound) treats osteoporosis (Disease) and osteoporosis (Disease) is associated with CYP27A1 (Gene) and CYP27A1 (Gene) is bound by Ergocalciferol (Compound)