DDInter1853 DDInter1274
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nefazodone
Tretinoin {u} (Compound) upregulates {v} (Gene) IKBKE
IKBKE {u} (Gene) is upregulated by {v} (Compound) Nefazodone
Tretinoin {u} (Compound) downregulates {v} (Gene) SPDEF
SPDEF {u} (Gene) is upregulated by {v} (Compound) Nefazodone
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Tretinoin {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Aripiprazole
Aripiprazole {u} (Compound) resembles {v} (Compound) Nefazodone
Tretinoin {u} (Compound) upregulates {v} (Gene) IKBKE
IKBKE {u} (Gene) is upregulated by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Nefazodone
Tretinoin {u} (Compound) downregulates {v} (Gene) SPDEF
SPDEF {u} (Gene) regulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Nefazodone
Tretinoin {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Nefazodone
Tretinoin {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Nefazodone
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Tretinoin (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is upregulated by Nefazodone (Compound)
Tretinoin (Compound) downregulates SPDEF (Gene) and SPDEF (Gene) is upregulated by Nefazodone (Compound)
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Nefazodone (Compound)
Tretinoin (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Nefazodone (Compound)
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aripiprazole (Compound) and Aripiprazole (Compound) resembles Nefazodone (Compound)
Tretinoin (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is upregulated by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Nefazodone (Compound)
Tretinoin (Compound) downregulates SPDEF (Gene) and SPDEF (Gene) regulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Nefazodone (Compound)
Tretinoin (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Quetiapine (Compound) and Quetiapine (Compound) resembles Nefazodone (Compound)
Tretinoin (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Nefazodone (Compound)