DDInter458 DDInter1261
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system through the blood-brain barrier.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Amiodarone
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxegol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Nefazodone
Nefazodone {u} may lead to a major life threatening interaction when taken with {v} Naloxegol
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is downregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Crizotinib
Crizotinib {u} may lead to a major life threatening interaction when taken with {v} Naloxegol
Cyclosporine {u} (Compound) upregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxegol
Cyclosporine {u} (Compound) upregulates {v} (Gene) CTSD
CTSD {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxegol
Cyclosporine {u} (Compound) upregulates {v} (Gene) CTSD
CTSD {u} (Gene) is downregulated by {v} (Compound) Imatinib
Imatinib {u} may lead to a major life threatening interaction when taken with {v} Naloxegol
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) P-Glycoprotein Inhibitors
P-Glycoprotein Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Amiodarone
Amiodarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Amiodarone (Compound) and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Cyclosporine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Amiodarone (Compound) and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Nefazodone (Compound) and Nefazodone may lead to a major life threatening interaction when taken with Naloxegol
Cyclosporine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is downregulated by Sorafenib (Compound) and Sorafenib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Cyclosporine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Crizotinib (Compound) and Crizotinib may lead to a major life threatening interaction when taken with Naloxegol
Cyclosporine (Compound) upregulates SQSTM1 (Gene) and SQSTM1 (Gene) is downregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol
Cyclosporine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is upregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol
Cyclosporine (Compound) upregulates CTSD (Gene) and CTSD (Gene) is downregulated by Imatinib (Compound) and Imatinib may lead to a major life threatening interaction when taken with Naloxegol
Cyclosporine (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class) and P-Glycoprotein Inhibitors (Pharmacologic Class) includes Amiodarone (Compound) and Amiodarone may cause a minor interaction that can limit clinical effects when taken with Naloxegol