DDInter458 DDInter1252
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. This regimen can be used in place of the older anti-proliferative [azathioprine] due to its stronger immunosuppressive potency. However, mycophenolic acid treatment is more expensive and requires therapeutic drug monitoring to optimize efficacy and minimize toxicity.[A249180,A249185] Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine. [Mycophenolate mofetil], a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is treated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNE2
CCNE2 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) binds {v} (Gene) FKBP1B
FKBP1B {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) LMNB2
LMNB2 {u} (Gene) is downregulated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is downregulated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is treated by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} (Compound) resembles {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) FBXO21
FBXO21 {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Cyclosporine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) interacts with {v} (Gene) PPBP
PPBP {u} (Gene) is upregulated by {v} (Compound) Mycophenolic acid
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is treated by Mycophenolic acid (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Mycophenolic acid (Compound)
Cyclosporine (Compound) downregulates CCNE2 (Gene) and CCNE2 (Gene) is upregulated by Mycophenolic acid (Compound)
Cyclosporine (Compound) binds FKBP1B (Gene) and FKBP1B (Gene) is upregulated by Mycophenolic acid (Compound)
Cyclosporine (Compound) downregulates LMNB2 (Gene) and LMNB2 (Gene) is downregulated by Mycophenolic acid (Compound)
Cyclosporine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is downregulated by Mycophenolic acid (Compound)
Cyclosporine (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Mycophenolic acid (Compound)
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is treated by Mycophenolate mofetil (Compound) and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by FBXO21 (Gene) and FBXO21 (Gene) is upregulated by Mycophenolic acid (Compound)
Cyclosporine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) interacts with PPBP (Gene) and PPBP (Gene) is upregulated by Mycophenolic acid (Compound)