DDInter1202 DDInter1956
Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) resembles {v} (Compound) Zalcitabine
Metronidazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Metronidazole {u} (Compound) causes {v} (Side Effect) Pollakiuria
Pollakiuria {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Metronidazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Metronidazole {u} (Compound) causes {v} (Side Effect) Pollakiuria
Pollakiuria {u} (Side Effect) is caused by {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Metronidazole {u} (Compound) causes {v} (Side Effect) Loose stools
Loose stools {u} (Side Effect) is caused by {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Eribulin
Eribulin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) resembles Zalcitabine (Compound)
Metronidazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Zalcitabine (Compound)
Metronidazole (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Zalcitabine (Compound)
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cytarabine (Compound) and Cytarabine (Compound) resembles Zalcitabine (Compound)
Metronidazole (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Metronidazole (Compound) causes Loose stools (Side Effect) and Loose stools (Side Effect) is caused by Decitabine (Compound) and Decitabine (Compound) resembles Zalcitabine (Compound)
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Zalcitabine (Compound)
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a minor interaction that can limit clinical effects when taken with Emtricitabine and Emtricitabine (Compound) resembles Zalcitabine (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Emtricitabine and Emtricitabine (Compound) resembles Zalcitabine (Compound)