DDInter1867 DDInter393
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Triflupromazine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Triflupromazine {u} (Compound) upregulates {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is downregulated by {v} (Compound) Clarithromycin
Triflupromazine {u} (Compound) resembles {v} (Compound) Trifluoperazine
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Triflupromazine {u} (Compound) resembles {v} (Compound) Methotrimeprazine
Methotrimeprazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Triflupromazine {u} (Compound) resembles {v} (Compound) Thioridazine
Thioridazine {u} may lead to a major life threatening interaction when taken with {v} Clarithromycin
Triflupromazine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Troleandomycin
Troleandomycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Triflupromazine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Triflupromazine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Dirithromycin
Dirithromycin {u} (Compound) resembles {v} (Compound) Clarithromycin
Triflupromazine {u} (Compound) upregulates {v} (Gene) GNPDA1
GNPDA1 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Clarithromycin
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Triflupromazine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Clarithromycin (Compound)
Triflupromazine (Compound) upregulates GNPDA1 (Gene) and GNPDA1 (Gene) is downregulated by Clarithromycin (Compound)
Triflupromazine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Triflupromazine (Compound) resembles Methotrimeprazine (Compound) and Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Triflupromazine (Compound) resembles Thioridazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Clarithromycin
Triflupromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Troleandomycin (Compound) and Troleandomycin (Compound) resembles Clarithromycin (Compound)
Triflupromazine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Triflupromazine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dirithromycin (Compound) and Dirithromycin (Compound) resembles Clarithromycin (Compound)
Triflupromazine (Compound) upregulates GNPDA1 (Gene) and GNPDA1 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)