DDInter1650 DDInter596
Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.[A1573,A257614,L45231] However, one of the major side effects of doxorubicin is cardiotoxicity, which excludes patients with poor heart function and requires treatment termination once the maximally tolerated cumulative dose is reached.
Secobarbital {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Daunorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) resembles {v} (Compound) Amobarbital
Amobarbital {u} (Compound) causes {v} (Side Effect) Dermatitis exfoliative
Dermatitis exfoliative {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) downregulates {v} (Gene) TSKU
TSKU {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) resembles {v} (Compound) Thiopental
Thiopental {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) binds {v} (Gene) GRIK2
GRIK2 {u} (Gene) interacts with {v} (Gene) CALCOCO1
CALCOCO1 {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) interacts with {v} (Gene) APOE
APOE {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) binds {v} (Gene) GABRA1
GABRA1 {u} (Gene) regulates {v} (Gene) KIT
KIT {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Secobarbital {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) interacts with {v} (Gene) DNAJB1
DNAJB1 {u} (Gene) is downregulated by {v} (Compound) Doxorubicin
Secobarbital (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Doxorubicin (Compound)
Secobarbital (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Daunorubicin (Compound) and Daunorubicin (Compound) resembles Doxorubicin (Compound)
Secobarbital (Compound) resembles Amobarbital (Compound) and Amobarbital (Compound) causes Dermatitis exfoliative (Side Effect) and Dermatitis exfoliative (Side Effect) is caused by Doxorubicin (Compound)
Secobarbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxorubicin (Compound)
Secobarbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital (Compound) downregulates TSKU (Gene) and TSKU (Gene) is downregulated by Doxorubicin (Compound)
Secobarbital (Compound) resembles Thiopental (Compound) and Thiopental (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxorubicin (Compound)
Secobarbital (Compound) binds GRIK2 (Gene) and GRIK2 (Gene) interacts with CALCOCO1 (Gene) and CALCOCO1 (Gene) is upregulated by Doxorubicin (Compound)
Secobarbital (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) interacts with APOE (Gene) and APOE (Gene) is upregulated by Doxorubicin (Compound)
Secobarbital (Compound) binds GABRA1 (Gene) and GABRA1 (Gene) regulates KIT (Gene) and KIT (Gene) is upregulated by Doxorubicin (Compound)
Secobarbital (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) interacts with DNAJB1 (Gene) and DNAJB1 (Gene) is downregulated by Doxorubicin (Compound)