DDInter909 DDInter1860
Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy".. The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment can be tailored specifically to the unique cancer genetics of each patient. Imatinib was approved on February 1st,2001 by the FDA and November 7th, 2001 by the EMA; however, its European approval has been withdrawn in October 2023.[A263036,L49746,L49751]
Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Halazepam
Halazepam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Triazolam
Imatinib {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Triazolam
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Halazepam
Halazepam {u} (Compound) resembles {v} (Compound) Camazepam
Camazepam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Camazepam
Camazepam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Clonazepam {u} (Compound) resembles {v} (Compound) Flunitrazepam
Flunitrazepam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Midazolam
Midazolam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Flunitrazepam
Flunitrazepam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlordiazepoxide
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Halazepam
Halazepam {u} (Compound) resembles {v} (Compound) Triazolam
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Halazepam and Halazepam (Compound) resembles Triazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Triazolam (Compound)
Imatinib (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Triazolam (Compound)
Imatinib (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Triazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Halazepam and Halazepam (Compound) resembles Camazepam (Compound) and Camazepam (Compound) resembles Triazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Camazepam (Compound) and Camazepam (Compound) resembles Triazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam and Clonazepam (Compound) resembles Flunitrazepam (Compound) and Flunitrazepam (Compound) resembles Triazolam (Compound)
Imatinib (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Midazolam (Compound) and Midazolam (Compound) resembles Triazolam (Compound)
Imatinib (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Flunitrazepam (Compound) and Flunitrazepam (Compound) resembles Triazolam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Halazepam (Compound) and Halazepam (Compound) resembles Triazolam (Compound)