DDInter458 DDInter1236
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Modafinil
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is downregulated by {v} (Compound) Modafinil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Modafinil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Modafinil
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) is regulated by {v} (Gene) IL13RA1
IL13RA1 {u} (Gene) is upregulated by {v} (Compound) Modafinil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Modafinil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Herpes simplex
Herpes simplex {u} (Side Effect) is caused by {v} (Compound) Aprepitant
Aprepitant {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Urine abnormality
Urine abnormality {u} (Side Effect) is caused by {v} (Compound) Esomeprazole
Esomeprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Modafinil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Cyclosporine {u} (Compound) upregulates {v} (Gene) RRP12
RRP12 {u} (Gene) regulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Modafinil
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Modafinil (Compound)
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Modafinil (Compound)
Cyclosporine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Modafinil (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Phenytoin (Compound) and Phenytoin (Compound) resembles Modafinil (Compound)
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) is regulated by IL13RA1 (Gene) and IL13RA1 (Gene) is upregulated by Modafinil (Compound)
Cyclosporine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Modafinil (Compound)
Cyclosporine (Compound) causes Herpes simplex (Side Effect) and Herpes simplex (Side Effect) is caused by Aprepitant (Compound) and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Modafinil
Cyclosporine (Compound) causes Urine abnormality (Side Effect) and Urine abnormality (Side Effect) is caused by Esomeprazole (Compound) and Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Modafinil
Cyclosporine (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a minor interaction that can limit clinical effects when taken with Modafinil
Cyclosporine (Compound) upregulates RRP12 (Gene) and RRP12 (Gene) regulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Modafinil (Compound)