DDInter1675 DDInter782
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form of netupitant [FDA label]. Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting as major side effects. Considered one of the most distressing side effects of chemotherapy, nausea and vomiting has an immense impact on the quality of life of patients receiving certain antineoplastic therapies .
Simvastatin {u} (Compound) treats {v} (Disease) atherosclerosis
Simvastatin {u} (Compound) binds {v} (Gene) ABCC2
Simvastatin {u} (Compound) upregulates {v} (Gene) ANKRD10
Simvastatin {u} (Compound) downregulates {v} (Gene) PNP
Simvastatin {u} (Compound) causes {v} (Side Effect) Cataract
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dapagliflozin
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Liothyronine
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duvelisib
Simvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Interferon alfacon-1
Simvastatin {u} may lead to a major life threatening interaction when taken with {v} Colchicine
Simvastatin (Compound) treats atherosclerosis (Disease)
Simvastatin (Compound) binds ABCC2 (Gene)
Simvastatin (Compound) upregulates ANKRD10 (Gene)
Simvastatin (Compound) downregulates PNP (Gene)
Simvastatin (Compound) causes Cataract (Side Effect)
Simvastatin may cause a minor interaction that can limit clinical effects when taken with Dapagliflozin
Simvastatin may cause a minor interaction that can limit clinical effects when taken with Liothyronine
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1
Simvastatin may lead to a major life threatening interaction when taken with Colchicine