DDInter596 DDInter1627
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) upregulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) downregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) upregulates {v} (Gene) PTK2B
PTK2B {u} (Gene) covaries with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) upregulates {v} (Gene) APOE
APOE {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is associated with {v} (Gene) SCN10A
SCN10A {u} (Gene) is bound by {v} (Compound) Rufinamide
Doxorubicin {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) interacts with {v} (Gene) SCN5A
SCN5A {u} (Gene) is bound by {v} (Compound) Rufinamide
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Doxorubicin (Compound) upregulates CES1 (Gene) and CES1 (Gene) is bound by Rufinamide (Compound)
Doxorubicin (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Doxorubicin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Doxorubicin (Compound) downregulates HMOX1 (Gene) and HMOX1 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Doxorubicin (Compound) upregulates IL1B (Gene) and IL1B (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Doxorubicin (Compound) upregulates PTK2B (Gene) and PTK2B (Gene) covaries with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Doxorubicin (Compound) upregulates APOE (Gene) and APOE (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)
Doxorubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is associated with SCN10A (Gene) and SCN10A (Gene) is bound by Rufinamide (Compound)
Doxorubicin (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) interacts with SCN5A (Gene) and SCN5A (Gene) is bound by Rufinamide (Compound)