DDInter458 DDInter1926
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic lymphoma [FDA label]. CLL is the most prevalent leukemia diagnosed in Western countries . Venetoclax was developed through reverse engineering of the BCL-2 protein family inhibitor, navitoclax . Venetoclax is approximately 10 times more potent than navitoclax with regard to induction of apoptosis in CLL cells . A new indication was approved in 2018 for the treatment patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who have received at least one prior therapy [FDA label]. Previously, this drug was indicated only for patients with 17p gene deletion .
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Secobarbital
Secobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venetoclax
Cyclosporine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Secobarbital
Secobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venetoclax
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nightmare
Nightmare {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Phenobarbital {u} may lead to a major life threatening interaction when taken with {v} Venetoclax
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Lapatinib
Lapatinib {u} may lead to a major life threatening interaction when taken with {v} Venetoclax
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is upregulated by {v} (Compound) Danazol
Danazol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venetoclax
Cyclosporine {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Digoxin
Digoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venetoclax
Cyclosporine {u} (Compound) upregulates {v} (Gene) GFPT1
GFPT1 {u} (Gene) is upregulated by {v} (Compound) Sorafenib
Sorafenib {u} may lead to a major life threatening interaction when taken with {v} Venetoclax
Cyclosporine {u} (Compound) upregulates {v} (Gene) GLRX
GLRX {u} (Gene) is downregulated by {v} (Compound) Dabrafenib
Dabrafenib {u} may lead to a major life threatening interaction when taken with {v} Venetoclax
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is upregulated by {v} (Compound) Danazol
Danazol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venetoclax
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venetoclax
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Secobarbital (Compound) and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Cyclosporine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Secobarbital (Compound) and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Cyclosporine (Compound) causes Nightmare (Side Effect) and Nightmare (Side Effect) is caused by Phenobarbital (Compound) and Phenobarbital may lead to a major life threatening interaction when taken with Venetoclax
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Lapatinib (Compound) and Lapatinib may lead to a major life threatening interaction when taken with Venetoclax
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Cyclosporine (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Digoxin (Compound) and Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Cyclosporine (Compound) upregulates GFPT1 (Gene) and GFPT1 (Gene) is upregulated by Sorafenib (Compound) and Sorafenib may lead to a major life threatening interaction when taken with Venetoclax
Cyclosporine (Compound) upregulates GLRX (Gene) and GLRX (Gene) is downregulated by Dabrafenib (Compound) and Dabrafenib may lead to a major life threatening interaction when taken with Venetoclax
Cyclosporine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is upregulated by Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax
Cyclosporine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax