DDInter388 DDInter416
Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the inhibition of serotonin reuptake, and among all the SSRIs, citalopram appears to be the most selective toward serotonin reuptake inhibition.[A261316,A14720] Specifically, it has a very minimal effect on dopamine and norepinephrine transportation and virtually no affinity for muscarinic, histaminergic, or GABAergic receptors. Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 years or older.
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers . The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot .
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenoxylate
Diphenoxylate {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Citalopram {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Clotrimazole
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenoxylate
Diphenoxylate {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Bifonazole
Bifonazole {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Methadone
Methadone {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenoxylate
Diphenoxylate {u} (Compound) resembles {v} (Compound) Diphenidol
Diphenidol {u} (Compound) resembles {v} (Compound) Clotrimazole
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Clotrimazole (Compound)
Citalopram (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clotrimazole (Compound)
Citalopram (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Clotrimazole (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide (Compound) resembles Methadone (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Clotrimazole (Compound)
Citalopram (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Citalopram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Bifonazole (Compound) and Bifonazole (Compound) resembles Clotrimazole (Compound)
Citalopram (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Loperamide (Compound) and Loperamide (Compound) resembles Clotrimazole (Compound)
Citalopram (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Methadone (Compound) and Methadone (Compound) resembles Clotrimazole (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Diphenidol (Compound) and Diphenidol (Compound) resembles Clotrimazole (Compound)