DDInter1035 DDInter131
Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenalidomide is much safer and potent than thalidomide, with fewer adverse effects and toxicities.[A714, A228543] Thalidomide and its analogues, including lenalidomide, are referred to as immunomodulatory imide drugs (also known as cereblon modulators), which are a class of immunomodulatory drugs that contain an imide group. Lenalidomide works through various mechanisms of actions that promote malignant cell death and enhance host immunity
Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted FDA approval on 18 October 2016. In November 2022, the manufacturer (Genentech) voluntarily withdrew the use of atezolizumab for the treatment of urothelial carcinoma, previously approved under the FDA's Accelerated Approval Program. The rest of atezolizumab indications remain unaffected.
Lenalidomide {u} (Compound) resembles {v} (Compound) Thalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Lenalidomide {u} (Compound) treats {v} (Disease) hematologic cancer
Lenalidomide {u} (Compound) binds {v} (Gene) PTGS2
Lenalidomide {u} (Compound) upregulates {v} (Gene) RRP8
Lenalidomide {u} (Compound) downregulates {v} (Gene) GDF15
Lenalidomide {u} (Compound) causes {v} (Side Effect) Cholecystitis
Lenalidomide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Lenalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cabozantinib
Lenalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Lenalidomide (Compound) resembles Thalidomide (Compound)
Lenalidomide (Compound) resembles Pomalidomide (Compound)
Lenalidomide (Compound) treats hematologic cancer (Disease)
Lenalidomide (Compound) binds PTGS2 (Gene)
Lenalidomide (Compound) upregulates RRP8 (Gene)
Lenalidomide (Compound) downregulates GDF15 (Gene)
Lenalidomide (Compound) causes Cholecystitis (Side Effect)
Lenalidomide may cause a minor interaction that can limit clinical effects when taken with Warfarin
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol