DDInter557 DDInter1545
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described in dogs in 1927.
Dihydroergotamine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Pseudoephedrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Pseudoephedrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Pseudoephedrine
Dihydroergotamine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) interacts with {v} (Gene) ADRB1
ADRB1 {u} (Gene) is bound by {v} (Compound) Pseudoephedrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Ventricular fibrillation
Ventricular fibrillation {u} (Side Effect) is caused by {v} (Compound) Ephedrine
Ephedrine {u} (Compound) resembles {v} (Compound) Pseudoephedrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) binds {v} (Gene) ADRA1A
ADRA1A {u} (Gene) is bound by {v} (Compound) Pseudoephedrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergoloid mesylate
Ergoloid mesylate {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Ephedrine
Ephedrine {u} (Compound) resembles {v} (Compound) Pseudoephedrine
Dihydroergotamine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Pseudoephedrine (Compound)
Dihydroergotamine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Pseudoephedrine (Compound)
Dihydroergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Pseudoephedrine
Dihydroergotamine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) interacts with ADRB1 (Gene) and ADRB1 (Gene) is bound by Pseudoephedrine (Compound)
Dihydroergotamine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Phentermine (Compound) and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Dihydroergotamine (Compound) causes Ventricular fibrillation (Side Effect) and Ventricular fibrillation (Side Effect) is caused by Ephedrine (Compound) and Ephedrine (Compound) resembles Pseudoephedrine (Compound)
Dihydroergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Pseudoephedrine (Compound)
Dihydroergotamine (Compound) resembles Ergoloid mesylate (Compound) and Ergoloid mesylate (Compound) resembles Bromocriptine (Compound) and Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Ephedrine and Ephedrine (Compound) resembles Pseudoephedrine (Compound)