DDInter1639 DDInter55
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used in men for whom oral treatment is either contraindicated or ineffective. After administration, alprostadil promotes smooth muscle relaxation of the corpus cavernosal.[A257068,A257088] Alprostadil is also used in neonatal patients with congenital heart defects that depend on a patent ductus for survival until corrective or palliative surgery can be performed. This drug causes vasodilation by directly affecting vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants.[A34474,L45038,L45063]
Sapropterin {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Alprostadil
Sapropterin {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Dinoprost Tromethamine
Dinoprost Tromethamine {u} (Compound) resembles {v} (Compound) Alprostadil
Sapropterin {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alprostadil
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Dihomo-gamma-linolenic acid
Dihomo-gamma-linolenic acid {u} (Compound) resembles {v} (Compound) Alprostadil
Sapropterin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Ethanolamine Oleate
Ethanolamine Oleate {u} (Compound) resembles {v} (Compound) Alprostadil
Sapropterin {u} (Compound) upregulates {v} (Gene) SATB1
SATB1 {u} (Gene) is regulated by {v} (Gene) ABCC5
ABCC5 {u} (Gene) is bound by {v} (Compound) Alprostadil
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Dinoprostone
Dinoprostone {u} (Compound) resembles {v} (Compound) Alprostadil
Sapropterin {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alprostadil
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is upregulated by {v} (Compound) Dihomo-gamma-linolenic acid
Dihomo-gamma-linolenic acid {u} (Compound) resembles {v} (Compound) Alprostadil
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alprostadil
Sapropterin (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Alprostadil (Compound)
Sapropterin (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Dinoprost Tromethamine (Compound) and Dinoprost Tromethamine (Compound) resembles Alprostadil (Compound)
Sapropterin (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Alprostadil
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Dihomo-gamma-linolenic acid (Compound) and Dihomo-gamma-linolenic acid (Compound) resembles Alprostadil (Compound)
Sapropterin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Ethanolamine Oleate (Compound) and Ethanolamine Oleate (Compound) resembles Alprostadil (Compound)
Sapropterin (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is regulated by ABCC5 (Gene) and ABCC5 (Gene) is bound by Alprostadil (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Dinoprostone (Compound) and Dinoprostone (Compound) resembles Alprostadil (Compound)
Sapropterin (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Alprostadil
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is upregulated by Dihomo-gamma-linolenic acid (Compound) and Dihomo-gamma-linolenic acid (Compound) resembles Alprostadil (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Alprostadil