DDInter1834 DDInter1452
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders.[L386,L42105]
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Prednisolone
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Prednisolone
Prednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may lead to a major life threatening interaction when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) causes {v} (Side Effect) Mood swings
Mood swings {u} (Side Effect) is caused by {v} (Compound) Valproic acid
Valproic acid {u} may lead to a major life threatening interaction when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is treated by {v} (Compound) Valproic acid
Valproic acid {u} may lead to a major life threatening interaction when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) palliates {v} (Disease) bipolar disorder
bipolar disorder {u} (Disease) is palliated by {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inducers
Cytochrome P450 3A4 Inducers {u} (Pharmacologic Class) includes {v} (Compound) Carbamazepine
Carbamazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylbutyric acid
Topiramate {u} (Compound) palliates {v} (Disease) bipolar disorder
bipolar disorder {u} (Disease) is palliated by {v} (Compound) Valproic acid
Valproic acid {u} may lead to a major life threatening interaction when taken with {v} Phenylbutyric acid
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Topiramate (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Valproic acid (Compound) and Valproic acid may lead to a major life threatening interaction when taken with Phenylbutyric acid
Topiramate (Compound) causes Mood swings (Side Effect) and Mood swings (Side Effect) is caused by Valproic acid (Compound) and Valproic acid may lead to a major life threatening interaction when taken with Phenylbutyric acid
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is treated by Valproic acid (Compound) and Valproic acid may lead to a major life threatening interaction when taken with Phenylbutyric acid
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Topiramate (Compound) palliates bipolar disorder (Disease) and bipolar disorder (Disease) is palliated by Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Topiramate (Compound) is included by Cytochrome P450 3A4 Inducers (Pharmacologic Class) and Cytochrome P450 3A4 Inducers (Pharmacologic Class) includes Carbamazepine (Compound) and Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutyric acid
Topiramate (Compound) palliates bipolar disorder (Disease) and bipolar disorder (Disease) is palliated by Valproic acid (Compound) and Valproic acid may lead to a major life threatening interaction when taken with Phenylbutyric acid