DDInter82 DDInter1180
Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Amoxapine {u} (Compound) resembles {v} (Compound) Chlordiazepoxide
Amoxapine {u} (Compound) resembles {v} (Compound) Lorazepam
Amoxapine {u} (Compound) binds {v} (Gene) HTR7
Amoxapine {u} (Compound) upregulates {v} (Gene) MSMO1
Amoxapine {u} (Compound) causes {v} (Side Effect) Flatulence
Amoxapine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Amoxapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Amoxapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rucaparib
Amoxapine {u} may lead to a major life threatening interaction when taken with {v} Macimorelin
Amoxapine {u} may lead to a major life threatening interaction when taken with {v} Anagrelide
Amoxapine (Compound) resembles Chlordiazepoxide (Compound)
Amoxapine (Compound) resembles Lorazepam (Compound)
Amoxapine (Compound) binds HTR7 (Gene)
Amoxapine (Compound) upregulates MSMO1 (Gene)
Amoxapine (Compound) causes Flatulence (Side Effect)
Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Amoxapine may lead to a major life threatening interaction when taken with Macimorelin
Amoxapine may lead to a major life threatening interaction when taken with Anagrelide