DDInter689 DDInter576
Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_. Ethambutol was granted FDA approval on 6 November 1967.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Ethambutol {u} (Compound) downregulates {v} (Gene) TARBP1
TARBP1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethambutol {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Ethambutol {u} (Compound) downregulates {v} (Gene) TARBP1
TARBP1 {u} (Gene) regulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethambutol {u} (Compound) upregulates {v} (Gene) KLHL21
KLHL21 {u} (Gene) interacts with {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethambutol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tinidazole
Tinidazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Ethambutol {u} (Compound) upregulates {v} (Gene) KLHL21
KLHL21 {u} (Gene) is regulated by {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethambutol {u} (Compound) downregulates {v} (Gene) TARBP1
TARBP1 {u} (Gene) is regulated by {v} (Gene) GADD45A
GADD45A {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethambutol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tinidazole
Tinidazole {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Ethambutol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Hydroxychloroquine {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethambutol {u} (Compound) downregulates {v} (Gene) TARBP1
TARBP1 {u} (Gene) is regulated by {v} (Gene) FIS1
FIS1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethambutol (Compound) downregulates TARBP1 (Gene) and TARBP1 (Gene) is downregulated by Disulfiram (Compound)
Ethambutol (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Ethambutol (Compound) downregulates TARBP1 (Gene) and TARBP1 (Gene) regulates CXCL2 (Gene) and CXCL2 (Gene) is upregulated by Disulfiram (Compound)
Ethambutol (Compound) upregulates KLHL21 (Gene) and KLHL21 (Gene) interacts with PLK1 (Gene) and PLK1 (Gene) is downregulated by Disulfiram (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Ethambutol (Compound) upregulates KLHL21 (Gene) and KLHL21 (Gene) is regulated by DNAJB2 (Gene) and DNAJB2 (Gene) is upregulated by Disulfiram (Compound)
Ethambutol (Compound) downregulates TARBP1 (Gene) and TARBP1 (Gene) is regulated by GADD45A (Gene) and GADD45A (Gene) is upregulated by Disulfiram (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Disulfiram (Compound)
Ethambutol (Compound) downregulates TARBP1 (Gene) and TARBP1 (Gene) is regulated by FIS1 (Gene) and FIS1 (Gene) is downregulated by Disulfiram (Compound)