DDInter1881 DDInter1662
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zaleplon
Zaleplon {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zaleplon
Zaleplon {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Raltegravir
Raltegravir {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dofetilide
Dofetilide {u} (Compound) downregulates {v} (Gene) CTSD
CTSD {u} (Gene) is upregulated by {v} (Compound) Sertraline
Troglitazone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dofetilide
Dofetilide {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Sertraline
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Goserelin
Goserelin {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Sertraline
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ramelteon
Ramelteon {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Sertraline
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Goserelin
Goserelin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Encorafenib
Encorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Troglitazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ramelteon
Ramelteon {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Zaleplon and Zaleplon (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Zaleplon and Zaleplon (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Raltegravir and Raltegravir (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Dofetilide and Dofetilide (Compound) downregulates CTSD (Gene) and CTSD (Gene) is upregulated by Sertraline (Compound)
Troglitazone may cause a minor interaction that can limit clinical effects when taken with Dofetilide and Dofetilide (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Sertraline (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sertraline (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon and Ramelteon (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Sertraline (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon and Ramelteon (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)