DDInter1141 DDInter1233
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Megestrol acetate {u} (Compound) resembles {v} (Compound) Difluprednate
Difluprednate {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) resembles {v} (Compound) Fluoxymesterone
Fluoxymesterone {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) causes {v} (Side Effect) Blood cholesterol increased
Blood cholesterol increased {u} (Side Effect) is caused by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) resembles {v} (Compound) Cortisone acetate
Cortisone acetate {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} (Compound) downregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) resembles {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) downregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) palliates {v} (Disease) breast cancer
breast cancer {u} (Disease) is associated with {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) palliates {v} (Disease) breast cancer
breast cancer {u} (Disease) is associated with {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Mitotane
Megestrol acetate {u} (Compound) palliates {v} (Disease) breast cancer
breast cancer {u} (Disease) upregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Mitotane
Megestrol acetate (Compound) resembles Difluprednate (Compound) and Difluprednate (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mitotane (Compound)
Megestrol acetate (Compound) resembles Fluoxymesterone (Compound) and Fluoxymesterone (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Mitotane (Compound)
Megestrol acetate (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Mitotane (Compound)
Megestrol acetate (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) causes Blood cholesterol increased (Side Effect) and Blood cholesterol increased (Side Effect) is caused by Mitotane (Compound)
Megestrol acetate (Compound) resembles Cortisone acetate (Compound) and Cortisone acetate (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Mitotane (Compound)
Megestrol acetate (Compound) resembles Testosterone (Compound) and Testosterone (Compound) downregulates ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Mitotane (Compound)
Megestrol acetate (Compound) resembles Testosterone Propionate (Compound) and Testosterone Propionate (Compound) downregulates ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Mitotane (Compound)
Megestrol acetate (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is associated with AGR2 (Gene) and AGR2 (Gene) is upregulated by Mitotane (Compound)
Megestrol acetate (Compound) palliates breast cancer (Disease) and breast cancer (Disease) is associated with SHBG (Gene) and SHBG (Gene) is bound by Mitotane (Compound)
Megestrol acetate (Compound) palliates breast cancer (Disease) and breast cancer (Disease) upregulates NVL (Gene) and NVL (Gene) is downregulated by Mitotane (Compound)