DDInter917 DDInter899
A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Indinavir {u} (Compound) resembles {v} (Compound) Alvimopan
Indinavir {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
Indinavir {u} (Compound) binds {v} (Gene) CYP2D6
Indinavir {u} (Compound) upregulates {v} (Gene) SSBP2
Indinavir {u} (Compound) downregulates {v} (Gene) MIF
Indinavir {u} (Compound) causes {v} (Side Effect) Body temperature increased
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Medroxyprogesterone acetate
Indinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fluconazole
Indinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lidocaine
Indinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Indinavir (Compound) resembles Alvimopan (Compound)
Indinavir (Compound) treats acquired immunodeficiency syndrome (Disease)
Indinavir (Compound) binds CYP2D6 (Gene)
Indinavir (Compound) upregulates SSBP2 (Gene)
Indinavir (Compound) downregulates MIF (Gene)
Indinavir (Compound) causes Body temperature increased (Side Effect)
Indinavir may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesterone acetate
Indinavir may cause a minor interaction that can limit clinical effects when taken with Fluconazole
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin