DDInter458 DDInter351
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.[L43942,L44022]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Chloramphenicol
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Chloramphenicol
Cyclosporine {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Cefoperazone
Cefoperazone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Cyclophosphamide
Cyclophosphamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chloramphenicol
Cyclosporine {u} (Compound) upregulates {v} (Gene) CCNA1
CCNA1 {u} (Gene) regulates {v} (Gene) MOK
MOK {u} (Gene) is upregulated by {v} (Compound) Chloramphenicol
Cyclosporine {u} (Compound) upregulates {v} (Gene) C5
C5 {u} (Gene) is downregulated by {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Chloramphenicol (Compound)
Cyclosporine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Chloramphenicol (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Chloramphenicol (Compound)
Cyclosporine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Chloramphenicol (Compound)
Cyclosporine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Chloramphenicol (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Cefoperazone (Compound) and Cefoperazone may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Cyclophosphamide (Compound) and Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Citalopram (Compound) and Citalopram may cause a minor interaction that can limit clinical effects when taken with Chloramphenicol
Cyclosporine (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) regulates MOK (Gene) and MOK (Gene) is upregulated by Chloramphenicol (Compound)
Cyclosporine (Compound) upregulates C5 (Gene) and C5 (Gene) is downregulated by Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol