DDInter551 DDInter1055
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Diflunisal {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ofloxacin
Ofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) resembles {v} (Compound) Salsalate
Salsalate {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) causes {v} (Side Effect) Tubulointerstitial nephritis
Tubulointerstitial nephritis {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) resembles {v} (Compound) Mesalazine
Mesalazine {u} (Compound) downregulates {v} (Gene) HTATSF1
HTATSF1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) resembles {v} (Compound) Niclosamide
Niclosamide {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Diflunisal {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Diflunisal (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Levofloxacin (Compound)
Diflunisal (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Levofloxacin (Compound)
Diflunisal (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ofloxacin (Compound) and Ofloxacin (Compound) resembles Levofloxacin (Compound)
Diflunisal (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Diflunisal (Compound) resembles Salsalate (Compound) and Salsalate (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Levofloxacin (Compound)
Diflunisal (Compound) causes Tubulointerstitial nephritis (Side Effect) and Tubulointerstitial nephritis (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Diflunisal (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Levofloxacin (Compound)
Diflunisal (Compound) resembles Mesalazine (Compound) and Mesalazine (Compound) downregulates HTATSF1 (Gene) and HTATSF1 (Gene) is downregulated by Levofloxacin (Compound)
Diflunisal (Compound) resembles Niclosamide (Compound) and Niclosamide (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)
Diflunisal (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)