DDInter1845 DDInter535
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Tranylcypromine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) resembles {v} (Compound) Phentermine
Phentermine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) resembles {v} (Compound) Ethotoin
Ethotoin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) ACD
ACD {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Tranylcypromine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Tranylcypromine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Diazoxide (Compound)
Tranylcypromine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Tranylcypromine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)
Tranylcypromine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Tranylcypromine (Compound) resembles Phentermine (Compound) and Phentermine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Diazoxide (Compound)
Tranylcypromine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by KRT19 (Gene) and KRT19 (Gene) is upregulated by Diazoxide (Compound)
Tranylcypromine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Diazoxide (Compound)
Tranylcypromine (Compound) resembles Ethotoin (Compound) and Ethotoin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diazoxide (Compound)
Tranylcypromine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with ACD (Gene) and ACD (Gene) is downregulated by Diazoxide (Compound)
Tranylcypromine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)