DDInter1042 DDInter1202
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
Metronidazole {u} (Compound) resembles {v} (Compound) Tinidazole
Metronidazole {u} (Compound) binds {v} (Gene) CYP2C8
Metronidazole {u} (Compound) upregulates {v} (Gene) ZNF586
Metronidazole {u} (Compound) is included by {v} (Pharmacologic Class) Nitroimidazoles
Metronidazole {u} (Compound) causes {v} (Side Effect) Loss of libido
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atomoxetine
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetrabenazine
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolate mofetil
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telbivudine
Metronidazole {u} may lead to a major life threatening interaction when taken with {v} Amprenavir
Metronidazole (Compound) resembles Tinidazole (Compound)
Metronidazole (Compound) binds CYP2C8 (Gene)
Metronidazole (Compound) upregulates ZNF586 (Gene)
Metronidazole (Compound) is included by Nitroimidazoles (Pharmacologic Class)
Metronidazole (Compound) causes Loss of libido (Side Effect)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Atomoxetine
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tetrabenazine
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine
Metronidazole may lead to a major life threatening interaction when taken with Amprenavir