DDInter1244 DDInter1747
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Hydromorphone
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxone
Morphine {u} (Compound) resembles {v} (Compound) Hydrocodone
Morphine {u} (Compound) binds {v} (Gene) UGT2B7
Morphine {u} (Compound) palliates {v} (Disease) coronary artery disease
Morphine {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Morphine {u} (Compound) causes {v} (Side Effect) Faecalith
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ephedrine
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Salmon calcitonin
Morphine (Compound) resembles Galantamine (Compound)
Morphine may lead to a major life threatening interaction when taken with Hydromorphone
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone
Morphine (Compound) resembles Hydrocodone (Compound)
Morphine (Compound) binds UGT2B7 (Gene)
Morphine (Compound) palliates coronary artery disease (Disease)
Morphine (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Morphine (Compound) causes Faecalith (Side Effect)
Morphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine
Morphine may cause a minor interaction that can limit clinical effects when taken with Salmon calcitonin