DDInter1938 DDInter694
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Vincristine {u} (Compound) upregulates {v} (Gene) IKZF1
IKZF1 {u} (Gene) is upregulated by {v} (Compound) Ethionamide
Vincristine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Ethionamide
Vincristine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Ethionamide
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Vincristine {u} (Compound) upregulates {v} (Gene) IKZF1
IKZF1 {u} (Gene) is regulated by {v} (Gene) CTNNAL1
CTNNAL1 {u} (Gene) is upregulated by {v} (Compound) Ethionamide
Vincristine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) NUDT9
NUDT9 {u} (Gene) is upregulated by {v} (Compound) Ethionamide
Vincristine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Clofarabine
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Vincristine {u} (Compound) causes {v} (Side Effect) Neuritis
Neuritis {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} (Compound) downregulates {v} (Gene) SUZ12
SUZ12 {u} (Gene) is downregulated by {v} (Compound) Ethionamide
Vincristine (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Ethionamide (Compound)
Vincristine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Ethionamide (Compound)
Vincristine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Ethionamide (Compound)
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Vincristine (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is regulated by CTNNAL1 (Gene) and CTNNAL1 (Gene) is upregulated by Ethionamide (Compound)
Vincristine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by NUDT9 (Gene) and NUDT9 (Gene) is upregulated by Ethionamide (Compound)
Vincristine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Clofarabine (Compound) and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Vincristine (Compound) causes Neuritis (Side Effect) and Neuritis (Side Effect) is caused by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine (Compound) downregulates SUZ12 (Gene) and SUZ12 (Gene) is downregulated by Ethionamide (Compound)