DDInter1619 DDInter149
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Azatadine
Ropinirole {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Ketotifen
Ketotifen {u} (Compound) resembles {v} (Compound) Azatadine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Azatadine
Ropinirole {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Ropinirole {u} (Compound) causes {v} (Side Effect) Dry eye
Dry eye {u} (Side Effect) is caused by {v} (Compound) Zaleplon
Zaleplon {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Ropinirole {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Azatadine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Mianserin
Mianserin {u} (Compound) resembles {v} (Compound) Azatadine
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cyclobenzaprine
Cyclobenzaprine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Ropinirole {u} (Compound) causes {v} (Side Effect) Dry eye
Dry eye {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azatadine
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Azatadine (Compound)
Ropinirole (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Ketotifen (Compound) and Ketotifen (Compound) resembles Azatadine (Compound)
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Azatadine (Compound)
Ropinirole (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clozapine (Compound) and Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Ropinirole (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Zaleplon (Compound) and Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Ropinirole (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Azatadine (Compound)
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mianserin (Compound) and Mianserin (Compound) resembles Azatadine (Compound)
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cyclobenzaprine (Compound) and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Ropinirole (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azatadine (Compound) and Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine