DDInter602 DDInter1544
Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate control, rhythm control, prevention of thromboembolic events, and treatment of the underlying disease. Similar to [amiodarone], dronedarone is a multichannel blocker that works to control rhythm and rate in atrial fibrillation. It meets criteria of all four Vaughan Williams antiarrhythmic drug classes by blocking sodium, potassium, and calcium ion channels and inhibiting β-adrenergic receptors.[A34604,L8699] Dronedarone is a related benzofuran compound to amiodarone but its chemical structure lacks iodine moieties which are associated with amiodarone-induced thyroid problems.[A34604,T28] Additionally
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Dronedarone {u} (Compound) resembles {v} (Compound) Ibutilide
Dronedarone {u} (Compound) binds {v} (Gene) CACNA1F
Dronedarone {u} (Compound) causes {v} (Side Effect) Skin disorder
Dronedarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Dronedarone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Dronedarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisacodyl
Dronedarone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Dronedarone {u} may lead to a major life threatening interaction when taken with {v} Gilteritinib
Dronedarone {u} may lead to a major life threatening interaction when taken with {v} Sorafenib
Dronedarone (Compound) resembles Ibutilide (Compound)
Dronedarone (Compound) binds CACNA1F (Gene)
Dronedarone (Compound) causes Skin disorder (Side Effect)
Dronedarone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Dronedarone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Dronedarone may lead to a major life threatening interaction when taken with Gilteritinib
Dronedarone may lead to a major life threatening interaction when taken with Sorafenib