DDInter336 DDInter781
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Celecoxib {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Rhinitis
Rhinitis {u} (Side Effect) is caused by {v} (Compound) Cilazapril
Cilazapril {u} (Compound) resembles {v} (Compound) Fosinopril
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Hypertensive crisis
Hypertensive crisis {u} (Side Effect) is caused by {v} (Compound) Fosinopril
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Fosinopril
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Celecoxib {u} (Compound) binds {v} (Gene) PDPK1
PDPK1 {u} (Gene) regulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is upregulated by {v} (Compound) Fosinopril
Celecoxib {u} (Compound) palliates {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is associated with {v} (Gene) ACE
ACE {u} (Gene) is bound by {v} (Compound) Fosinopril
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Lisinopril
Lisinopril {u} (Compound) resembles {v} (Compound) Fosinopril
Celecoxib {u} (Compound) downregulates {v} (Gene) ZMIZ1
ZMIZ1 {u} (Gene) regulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is upregulated by {v} (Compound) Fosinopril
Celecoxib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Fosinopril (Compound)
Celecoxib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Celecoxib (Compound) causes Rhinitis (Side Effect) and Rhinitis (Side Effect) is caused by Cilazapril (Compound) and Cilazapril (Compound) resembles Fosinopril (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Hypertensive crisis (Side Effect) and Hypertensive crisis (Side Effect) is caused by Fosinopril (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Fosinopril (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enalapril (Compound) and Enalapril (Compound) resembles Fosinopril (Compound)
Celecoxib (Compound) binds PDPK1 (Gene) and PDPK1 (Gene) regulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Fosinopril (Compound)
Celecoxib (Compound) palliates systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is associated with ACE (Gene) and ACE (Gene) is bound by Fosinopril (Compound)
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Lisinopril (Compound) and Lisinopril (Compound) resembles Fosinopril (Compound)
Celecoxib (Compound) downregulates ZMIZ1 (Gene) and ZMIZ1 (Gene) regulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Fosinopril (Compound)