DDInter298 DDInter904
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Idarubicin
Carboplatin {u} (Compound) causes {v} (Side Effect) Extravasation
Extravasation {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Carboplatin {u} (Compound) causes {v} (Side Effect) Extravasation
Extravasation {u} (Side Effect) is caused by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Carboplatin {u} (Compound) causes {v} (Side Effect) Fluid overload
Fluid overload {u} (Side Effect) is caused by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Carboplatin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Idarubicin
Carboplatin {u} (Compound) causes {v} (Side Effect) Phlebitis
Phlebitis {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Idarubicin
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) downregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) SOX2
SOX2 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Idarubicin (Compound)
Carboplatin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Idarubicin (Compound)
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Carboplatin (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Carboplatin (Compound) causes Fluid overload (Side Effect) and Fluid overload (Side Effect) is caused by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Carboplatin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Carboplatin (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Idarubicin
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) downregulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Idarubicin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with SOX2 (Gene) and SOX2 (Gene) is upregulated by Idarubicin (Compound)