DDInter298 DDInter1705
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Carboplatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Sparfloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Carboplatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Lomefloxacin
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Carboplatin {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Carboplatin {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Sparfloxacin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is associated with {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sparfloxacin
Carboplatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) regulates {v} (Gene) SDC1
SDC1 {u} (Gene) is downregulated by {v} (Compound) Sparfloxacin
Carboplatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Etoposide
Etoposide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Carboplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sparfloxacin
Carboplatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Sparfloxacin (Compound)
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sparfloxacin (Compound)
Carboplatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Lomefloxacin (Compound) and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Carboplatin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Sparfloxacin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Carboplatin (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Sparfloxacin
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is associated with ABCB1 (Gene) and ABCB1 (Gene) is bound by Sparfloxacin (Compound)
Carboplatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) regulates SDC1 (Gene) and SDC1 (Gene) is downregulated by Sparfloxacin (Compound)
Carboplatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Etoposide (Compound) and Etoposide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Carboplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) is treated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin