DDInter268 DDInter554
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digitalis_ plant, studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Digoxin
Calcitriol {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Calcitriol {u} (Compound) downregulates {v} (Gene) CCL2
CCL2 {u} (Gene) is upregulated by {v} (Compound) Digoxin
Calcitriol {u} (Compound) upregulates {v} (Gene) C2CD5
C2CD5 {u} (Gene) is downregulated by {v} (Compound) Digoxin
Calcitriol {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Digoxin
Calcitriol {u} (Compound) causes {v} (Side Effect) Apathy
Apathy {u} (Side Effect) is caused by {v} (Compound) Digoxin
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Digoxin
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Digitoxin
Digitoxin {u} (Compound) resembles {v} (Compound) Digoxin
Calcitriol {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) is upregulated by {v} (Compound) Ouabain
Ouabain {u} (Compound) resembles {v} (Compound) Digoxin
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digoxin (Compound)
Calcitriol (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Digoxin (Compound)
Calcitriol (Compound) downregulates CCL2 (Gene) and CCL2 (Gene) is upregulated by Digoxin (Compound)
Calcitriol (Compound) upregulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Digoxin (Compound)
Calcitriol (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Digoxin (Compound)
Calcitriol (Compound) causes Apathy (Side Effect) and Apathy (Side Effect) is caused by Digoxin (Compound)
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Digoxin
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Digoxin
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digitoxin (Compound) and Digitoxin (Compound) resembles Digoxin (Compound)
Calcitriol (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Ouabain (Compound) and Ouabain (Compound) resembles Digoxin (Compound)