DDInter1158 DDInter900
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID. On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Ibuprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Carprofen
Carprofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Mesalazine {u} (Compound) binds {v} (Gene) PPARG
PPARG {u} (Gene) is bound by {v} (Compound) Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Urethral disorder
Urethral disorder {u} (Side Effect) is caused by {v} (Compound) Baclofen
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Reye's syndrome
Reye's syndrome {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may lead to a major life threatening interaction when taken with {v} Ibuprofen
Mesalazine {u} (Compound) causes {v} (Side Effect) Sinus tachycardia
Sinus tachycardia {u} (Side Effect) is caused by {v} (Compound) Bepridil
Bepridil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Ibuprofen (Compound)
Mesalazine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Mesalazine (Compound) resembles Diflunisal (Compound) and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Carprofen (Compound) and Carprofen (Compound) resembles Ibuprofen (Compound)
Mesalazine (Compound) binds PPARG (Gene) and PPARG (Gene) is bound by Indomethacin (Compound) and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Mesalazine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Baclofen (Compound) and Baclofen (Compound) resembles Ibuprofen (Compound)
Mesalazine (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Phenytoin (Compound) and Phenytoin may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Mesalazine (Compound) causes Reye's syndrome (Side Effect) and Reye's syndrome (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may lead to a major life threatening interaction when taken with Ibuprofen
Mesalazine (Compound) causes Sinus tachycardia (Side Effect) and Sinus tachycardia (Side Effect) is caused by Bepridil (Compound) and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen