DDInter477 DDInter336
Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal tryptophan covalently bonded to decanoic acid.[A231374, L32534] Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil samples from Mount Ararat in Turkey. Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed d
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Celecoxib {u} (Compound) binds {v} (Gene) CA14
Celecoxib {u} (Compound) upregulates {v} (Gene) ST3GAL5
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Celecoxib {u} (Compound) downregulates {v} (Gene) TUBB2B
Celecoxib {u} (Compound) causes {v} (Side Effect) Nausea
Celecoxib (Compound) resembles Sulfaphenazole (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound)
Celecoxib (Compound) binds CA14 (Gene)
Celecoxib (Compound) upregulates ST3GAL5 (Gene)
Celecoxib (Compound) palliates osteoarthritis (Disease)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Celecoxib (Compound) downregulates TUBB2B (Gene)
Celecoxib (Compound) causes Nausea (Side Effect)