DDInter771 DDInter1627
Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits. In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (TH
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Folic acid {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Rufinamide
Folic acid {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Folic acid {u} (Compound) resembles {v} (Compound) Leucovorin
Leucovorin {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Folic acid {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Folic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Folic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colestipol
Colestipol {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Folic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Oxcarbazepine {u} (Compound) binds {v} (Gene) SCN5A
SCN5A {u} (Gene) is bound by {v} (Compound) Rufinamide
Folic acid {u} may lead to a major life threatening interaction when taken with {v} Fluorouracil
Fluorouracil {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Folic acid {u} may lead to a major life threatening interaction when taken with {v} Fluorouracil
Fluorouracil {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Folic acid {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methotrexate
Methotrexate {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Rufinamide
Folic acid (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Rufinamide (Compound)
Folic acid (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Folic acid (Compound) resembles Leucovorin (Compound) and Leucovorin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rufinamide (Compound)
Folic acid (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Colestipol and Colestipol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Rufinamide (Compound)
Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) binds SCN5A (Gene) and SCN5A (Gene) is bound by Rufinamide (Compound)
Folic acid may lead to a major life threatening interaction when taken with Fluorouracil and Fluorouracil (Compound) binds ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)
Folic acid may lead to a major life threatening interaction when taken with Fluorouracil and Fluorouracil (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Rufinamide (Compound)
Folic acid (Compound) resembles Methotrexate (Compound) and Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate (Compound) binds ALB (Gene) and ALB (Gene) is bound by Rufinamide (Compound)