DDInter596 DDInter907
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Iloperidone
Doxorubicin {u} (Compound) upregulates {v} (Gene) DKK3
DKK3 {u} (Gene) is downregulated by {v} (Compound) Iloperidone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Iloperidone
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Doxorubicin {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Iloperidone
Doxorubicin {u} (Compound) upregulates {v} (Gene) DKK3
DKK3 {u} (Gene) is downregulated by {v} (Compound) Sitagliptin
Sitagliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloperidone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Iloperidone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Aphthous stomatitis
Aphthous stomatitis {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloperidone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Nystagmus
Nystagmus {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Iloperidone
Doxorubicin {u} (Compound) causes {v} (Side Effect) Dyspnoea exertional
Dyspnoea exertional {u} (Side Effect) is caused by {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Iloperidone (Compound)
Doxorubicin (Compound) upregulates DKK3 (Gene) and DKK3 (Gene) is downregulated by Iloperidone (Compound)
Doxorubicin (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Iloperidone (Compound)
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Iloperidone
Doxorubicin (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Gefitinib (Compound) and Gefitinib (Compound) resembles Iloperidone (Compound)
Doxorubicin (Compound) upregulates DKK3 (Gene) and DKK3 (Gene) is downregulated by Sitagliptin (Compound) and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone
Doxorubicin (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Gefitinib (Compound) and Gefitinib (Compound) resembles Iloperidone (Compound)
Doxorubicin (Compound) causes Aphthous stomatitis (Side Effect) and Aphthous stomatitis (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone
Doxorubicin (Compound) causes Nystagmus (Side Effect) and Nystagmus (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Iloperidone
Doxorubicin (Compound) causes Dyspnoea exertional (Side Effect) and Dyspnoea exertional (Side Effect) is caused by Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Iloperidone