DDInter1815 DDInter1544
Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium]. Tiotropium was granted FDA approval on 30 January 2004.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Tiotropium {u} (Compound) resembles {v} (Compound) Methylscopolamine bromide
Tiotropium {u} (Compound) treats {v} (Disease) asthma
Tiotropium {u} (Compound) binds {v} (Gene) CHRM2
Tiotropium {u} (Compound) causes {v} (Side Effect) Oropharyngeal candidiasis
Tiotropium {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Tiotropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propiomazine
Tiotropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenindamine
Tiotropium {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aclidinium
Tiotropium (Compound) resembles Methylscopolamine bromide (Compound)
Tiotropium (Compound) treats asthma (Disease)
Tiotropium (Compound) binds CHRM2 (Gene)
Tiotropium (Compound) causes Oropharyngeal candidiasis (Side Effect)
Tiotropium may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine
Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine
Tiotropium (Compound) resembles Aclidinium (Compound) and Tiotropium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium