DDInter1448 DDInter125
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including the treatment of hypertensive episodes, prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and treatment of pharmacologically-induced mydriasis.[L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and topically.
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Phentolamine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Asenapine
Phentolamine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Asenapine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Asenapine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amoxapine
Amoxapine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Phentolamine {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Phentolamine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Asenapine
Phentolamine {u} (Compound) resembles {v} (Compound) Naphazoline
Naphazoline {u} (Compound) binds {v} (Gene) ADRA2A
ADRA2A {u} (Gene) is bound by {v} (Compound) Asenapine
Phentolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) binds {v} (Gene) HRH2
HRH2 {u} (Gene) is bound by {v} (Compound) Asenapine
Phentolamine {u} (Compound) resembles {v} (Compound) Antazoline
Antazoline {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Asenapine
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Asenapine (Compound)
Phentolamine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Asenapine (Compound)
Phentolamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Asenapine (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) resembles Asenapine (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amoxapine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Phentolamine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Phentolamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Asenapine (Compound)
Phentolamine (Compound) resembles Naphazoline (Compound) and Naphazoline (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Asenapine (Compound)
Phentolamine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) binds HRH2 (Gene) and HRH2 (Gene) is bound by Asenapine (Compound)
Phentolamine (Compound) resembles Antazoline (Compound) and Antazoline (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Asenapine (Compound)