DDInter576 DDInter410
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine.
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clomipramine
Disulfiram {u} (Compound) causes {v} (Side Effect) Dermatitis atopic
Dermatitis atopic {u} (Side Effect) is caused by {v} (Compound) Clomipramine
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Adinazolam
Adinazolam {u} (Compound) resembles {v} (Compound) Clomipramine
Disulfiram {u} (Compound) causes {v} (Side Effect) Dermatitis atopic
Dermatitis atopic {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Clomipramine
Disulfiram {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) Clomipramine
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clomipramine
Disulfiram {u} (Compound) causes {v} (Side Effect) Breath odour
Breath odour {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clomipramine
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) resembles {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Clomipramine
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trimipramine
Trimipramine {u} (Compound) resembles {v} (Compound) Clomipramine
Disulfiram {u} (Compound) causes {v} (Side Effect) Breath odour
Breath odour {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may lead to a major life threatening interaction when taken with {v} Clomipramine
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clomipramine (Compound)
Disulfiram (Compound) causes Dermatitis atopic (Side Effect) and Dermatitis atopic (Side Effect) is caused by Clomipramine (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Adinazolam (Compound) and Adinazolam (Compound) resembles Clomipramine (Compound)
Disulfiram (Compound) causes Dermatitis atopic (Side Effect) and Dermatitis atopic (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Clomipramine (Compound)
Disulfiram (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Thioridazine (Compound) and Thioridazine (Compound) resembles Clomipramine (Compound)
Disulfiram (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Clomipramine
Disulfiram (Compound) causes Breath odour (Side Effect) and Breath odour (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine
Disulfiram (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) resembles panic disorder (Disease) and panic disorder (Disease) is palliated by Clomipramine (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trimipramine (Compound) and Trimipramine (Compound) resembles Clomipramine (Compound)
Disulfiram (Compound) causes Breath odour (Side Effect) and Breath odour (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may lead to a major life threatening interaction when taken with Clomipramine