DDInter1570 DDInter1164
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. Another well-known benefit of this drug is modest weight loss, making it an effective choice for obese patients type II diabetes. Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the US in 1995.
Ranolazine {u} (Compound) upregulates {v} (Gene) WDR7
WDR7 {u} (Gene) is upregulated by {v} (Compound) Metformin
Ranolazine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Metformin
Ranolazine {u} (Compound) upregulates {v} (Gene) WDR7
WDR7 {u} (Gene) is regulated by {v} (Gene) NDUFA1
NDUFA1 {u} (Gene) is bound by {v} (Compound) Metformin
Ranolazine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Memantine
Memantine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metformin
Ranolazine {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Quetiapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Ranolazine {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Midodrine
Midodrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metformin
Ranolazine {u} (Compound) resembles {v} (Compound) Guaifenesin
Guaifenesin {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Metformin
Ranolazine {u} (Compound) resembles {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Metformin
Ranolazine {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Ranolazine {u} (Compound) resembles {v} (Compound) Eprazinone
Eprazinone {u} (Compound) resembles {v} (Compound) Benzphetamine
Benzphetamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metformin
Ranolazine (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Metformin (Compound)
Ranolazine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Metformin (Compound)
Ranolazine (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is regulated by NDUFA1 (Gene) and NDUFA1 (Gene) is bound by Metformin (Compound)
Ranolazine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Memantine (Compound) and Memantine may cause a minor interaction that can limit clinical effects when taken with Metformin
Ranolazine (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Quetiapine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Metformin
Ranolazine (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Midodrine (Compound) and Midodrine may cause a minor interaction that can limit clinical effects when taken with Metformin
Ranolazine (Compound) resembles Guaifenesin (Compound) and Guaifenesin (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Metformin (Compound)
Ranolazine (Compound) resembles Bupivacaine (Compound) and Bupivacaine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Metformin (Compound)
Ranolazine (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Indomethacin (Compound) and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Metformin
Ranolazine (Compound) resembles Eprazinone (Compound) and Eprazinone (Compound) resembles Benzphetamine (Compound) and Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with Metformin