DDInter499 DDInter150
A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Denileukin diftitox {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Moxifloxacin {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Denileukin diftitox {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Sparfloxacin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Denileukin diftitox {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Zidovudine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleoside Analog
Nucleoside Analog {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Denileukin diftitox {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Zidovudine {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Denileukin diftitox {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Denileukin diftitox {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Denileukin diftitox {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) upregulates {v} (Gene) INTS3
INTS3 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Denileukin diftitox {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cladribine {u} (Compound) treats {v} (Disease) multiple sclerosis
multiple sclerosis {u} (Disease) is treated by {v} (Compound) Azathioprine
Denileukin diftitox {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) causes {v} (Side Effect) Hodgkin's disease
Hodgkin's disease {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Denileukin diftitox {u} may lead to a major life threatening interaction when taken with {v} Clozapine
Clozapine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Denileukin diftitox may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Azathioprine (Compound)
Denileukin diftitox may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin and Sparfloxacin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Azathioprine (Compound)
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Azathioprine (Compound)
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) is downregulated by Azathioprine (Compound)
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate (Compound) downregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Denileukin diftitox may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) upregulates INTS3 (Gene) and INTS3 (Gene) is downregulated by Azathioprine (Compound)
Denileukin diftitox may lead to a major life threatening interaction when taken with Cladribine and Cladribine (Compound) treats multiple sclerosis (Disease) and multiple sclerosis (Disease) is treated by Azathioprine (Compound)
Denileukin diftitox may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) causes Hodgkin's disease (Side Effect) and Hodgkin's disease (Side Effect) is caused by Azathioprine (Compound)
Denileukin diftitox may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)