DDInter948 DDInter576
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
Disulfiram {u} (Compound) binds {v} (Gene) DBH
Disulfiram {u} (Compound) upregulates {v} (Gene) FHL2
Disulfiram {u} (Compound) is included by {v} (Pharmacologic Class) Acetyl Aldehyde Dehydrogenase Inhibitors
Disulfiram {u} (Compound) downregulates {v} (Gene) NR2F6
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Disulfiram (Compound) treats alcohol dependence (Disease)
Disulfiram (Compound) binds DBH (Gene)
Disulfiram (Compound) upregulates FHL2 (Gene)
Disulfiram (Compound) is included by Acetyl Aldehyde Dehydrogenase Inhibitors (Pharmacologic Class)
Disulfiram (Compound) downregulates NR2F6 (Gene)
Disulfiram (Compound) causes Neuropathy (Side Effect)