DDInter268 DDInter1360
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine]. Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Oxcarbazepine
Calcitriol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Calcitriol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Calcitriol {u} (Compound) causes {v} (Side Effect) Nephrolithiasis
Nephrolithiasis {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Oxcarbazepine
Calcitriol {u} (Compound) causes {v} (Side Effect) Apathy
Apathy {u} (Side Effect) is caused by {v} (Compound) Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Calcitriol {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxcarbazepine (Compound)
Calcitriol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Oxcarbazepine (Compound)
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Indapamide (Compound) and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Calcitriol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Calcitriol (Compound) causes Nephrolithiasis (Side Effect) and Nephrolithiasis (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Oxcarbazepine
Calcitriol (Compound) causes Apathy (Side Effect) and Apathy (Side Effect) is caused by Clobazam (Compound) and Clobazam (Compound) resembles Oxcarbazepine (Compound)
Calcitriol (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)