DDInter405 DDInter1763
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) downregulates {v} (Gene) HDAC6
HDAC6 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) ANKRA2
ANKRA2 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) BCL7B
BCL7B {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) causes {v} (Side Effect) Febrile neutropenia
Febrile neutropenia {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Clofarabine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) downregulates {v} (Gene) HDAC6
HDAC6 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) ANKRA2
ANKRA2 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Clofarabine {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) kidney cancer
kidney cancer {u} (Disease) is treated by {v} (Compound) Temsirolimus
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Clofarabine (Compound) downregulates HDAC6 (Gene) and HDAC6 (Gene) is upregulated by Temsirolimus (Compound)
Clofarabine (Compound) upregulates ANKRA2 (Gene) and ANKRA2 (Gene) is upregulated by Temsirolimus (Compound)
Clofarabine (Compound) upregulates BCL7B (Gene) and BCL7B (Gene) is downregulated by Temsirolimus (Compound)
Clofarabine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Temsirolimus (Compound)
Clofarabine (Compound) causes Febrile neutropenia (Side Effect) and Febrile neutropenia (Side Effect) is caused by Temsirolimus (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Clofarabine (Compound) downregulates HDAC6 (Gene) and HDAC6 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Clofarabine (Compound) upregulates ANKRA2 (Gene) and ANKRA2 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Clofarabine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is associated with kidney cancer (Disease) and kidney cancer (Disease) is treated by Temsirolimus (Compound)