DDInter856 DDInter505
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52. It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients. Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing.
Desirudin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clove
Desirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venlafaxine
Desirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Selumetinib
Desirudin {u} may lead to a major life threatening interaction when taken with {v} Apixaban
Desirudin {u} may lead to a major life threatening interaction when taken with {v} Betrixaban
Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Desirudin may lead to a major life threatening interaction when taken with Apixaban
Desirudin may lead to a major life threatening interaction when taken with Betrixaban