DDInter336 DDInter1831
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Tolmetin
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Tolmetin
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Tolmetin
Celecoxib {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Tolmetin
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Lumiracoxib
Lumiracoxib {u} (Compound) resembles {v} (Compound) Tolmetin
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Indomethacin
Indomethacin {u} (Compound) resembles {v} (Compound) Tolmetin
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Ketorolac
Ketorolac {u} (Compound) resembles {v} (Compound) Tolmetin
Celecoxib {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Zolpidem
Zolpidem {u} (Compound) resembles {v} (Compound) Tolmetin
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Zolpidem
Zolpidem {u} (Compound) resembles {v} (Compound) Tolmetin
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is associated with {v} (Gene) CXCL8
CXCL8 {u} (Gene) is bound by {v} (Compound) Tolmetin
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Tolmetin (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Tolmetin (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Tolmetin (Compound)
Celecoxib (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Tolmetin (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Lumiracoxib (Compound) and Lumiracoxib (Compound) resembles Tolmetin (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Indomethacin (Compound) and Indomethacin (Compound) resembles Tolmetin (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Ketorolac (Compound) and Ketorolac (Compound) resembles Tolmetin (Compound)
Celecoxib (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Zolpidem (Compound) and Zolpidem (Compound) resembles Tolmetin (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zolpidem (Compound) and Zolpidem (Compound) resembles Tolmetin (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is associated with CXCL8 (Gene) and CXCL8 (Gene) is bound by Tolmetin (Compound)