DDInter557 DDInter1453
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Arteriospasm coronary
Arteriospasm coronary {u} (Side Effect) is caused by {v} (Compound) Phenylephrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Phenylephrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Arteriospasm coronary
Arteriospasm coronary {u} (Side Effect) is caused by {v} (Compound) Ergometrine
Ergometrine {u} may lead to a major life threatening interaction when taken with {v} Phenylephrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Palpitations
Palpitations {u} (Side Effect) is caused by {v} (Compound) Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Phenylephrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Visual impairment
Visual impairment {u} (Side Effect) is caused by {v} (Compound) Formoterol
Formoterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylephrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergoloid mesylate
Ergoloid mesylate {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Phenylephrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may lead to a major life threatening interaction when taken with {v} Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Phenylephrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Acute coronary syndrome
Acute coronary syndrome {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenylephrine
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Phenylephrine
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Methysergide
Methysergide {u} may lead to a major life threatening interaction when taken with {v} Phenylephrine
Dihydroergotamine (Compound) causes Arteriospasm coronary (Side Effect) and Arteriospasm coronary (Side Effect) is caused by Phenylephrine (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Phenylephrine
Dihydroergotamine (Compound) causes Arteriospasm coronary (Side Effect) and Arteriospasm coronary (Side Effect) is caused by Ergometrine (Compound) and Ergometrine may lead to a major life threatening interaction when taken with Phenylephrine
Dihydroergotamine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Epinephrine (Compound) and Epinephrine (Compound) resembles Phenylephrine (Compound)
Dihydroergotamine (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Formoterol (Compound) and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine
Dihydroergotamine (Compound) resembles Ergoloid mesylate (Compound) and Ergoloid mesylate (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Phenylephrine
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine (Compound) resembles Phenylephrine (Compound)
Dihydroergotamine (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Phentermine (Compound) and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine
Dihydroergotamine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Terbutaline (Compound) and Terbutaline (Compound) resembles Phenylephrine (Compound)
Dihydroergotamine (Compound) resembles Bromocriptine (Compound) and Bromocriptine (Compound) resembles Methysergide (Compound) and Methysergide may lead to a major life threatening interaction when taken with Phenylephrine