DDInter1158 DDInter551
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine {u} (Compound) resembles {v} (Compound) Aminosalicylic acid
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diflunisal
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Diflunisal
Mesalazine {u} (Compound) causes {v} (Side Effect) Photosensitivity reaction
Photosensitivity reaction {u} (Side Effect) is caused by {v} (Compound) Diflunisal
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine {u} (Compound) resembles {v} (Compound) Aminosalicylic acid
Aminosalicylic acid {u} (Compound) resembles {v} (Compound) Salicylic acid
Salicylic acid {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} (Compound) resembles {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Diflunisal
Mesalazine (Compound) resembles Diflunisal (Compound)
Mesalazine (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) resembles Diflunisal (Compound)
Mesalazine (Compound) resembles Aminosalicylic acid (Compound) and Aminosalicylic acid (Compound) resembles Diflunisal (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Diflunisal (Compound)
Mesalazine (Compound) causes Photosensitivity reaction (Side Effect) and Photosensitivity reaction (Side Effect) is caused by Diflunisal (Compound)
Mesalazine (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Diflunisal (Compound)
Mesalazine (Compound) resembles Aminosalicylic acid (Compound) and Aminosalicylic acid (Compound) resembles Salicylic acid (Compound) and Salicylic acid (Compound) resembles Diflunisal (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine (Compound) resembles Salsalate (Compound) and Salsalate (Compound) resembles Diflunisal (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Salsalate (Compound) and Salsalate (Compound) resembles Diflunisal (Compound)