DDInter1263 DDInter1376
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Oxycodone
Naltrexone {u} (Compound) resembles {v} (Compound) Hydrocodone
Naltrexone {u} (Compound) resembles {v} (Compound) Butorphanol
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
Naltrexone {u} (Compound) binds {v} (Gene) OPRD1
Naltrexone {u} (Compound) upregulates {v} (Gene) TSC22D3
Naltrexone {u} (Compound) is included by {v} (Pharmacologic Class) Opioid Antagonists
Naltrexone {u} (Compound) downregulates {v} (Gene) IER3
Naltrexone {u} (Compound) causes {v} (Side Effect) Dyspnoea
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorzoxazone
Naltrexone may lead to a major life threatening interaction when taken with Oxycodone
Naltrexone (Compound) resembles Hydrocodone (Compound)
Naltrexone (Compound) resembles Butorphanol (Compound)
Naltrexone (Compound) treats alcohol dependence (Disease)
Naltrexone (Compound) binds OPRD1 (Gene)
Naltrexone (Compound) upregulates TSC22D3 (Gene)
Naltrexone (Compound) is included by Opioid Antagonists (Pharmacologic Class)
Naltrexone (Compound) downregulates IER3 (Gene)
Naltrexone (Compound) causes Dyspnoea (Side Effect)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Chlorzoxazone