DDInter596 DDInter1726
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Doxorubicin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Doxorubicin {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Sulfinpyrazone
Doxorubicin {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Sulfinpyrazone
Doxorubicin {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Clotrimazole
Clotrimazole {u} (Compound) resembles {v} (Compound) Sulfinpyrazone
Doxorubicin {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) is regulated by {v} (Gene) ABCC5
ABCC5 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Doxorubicin {u} (Compound) upregulates {v} (Gene) PECR
PECR {u} (Gene) is upregulated by {v} (Compound) Vemurafenib
Vemurafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Doxorubicin {u} (Compound) upregulates {v} (Gene) WDR7
WDR7 {u} (Gene) is upregulated by {v} (Compound) Gefitinib
Gefitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Doxorubicin {u} (Compound) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfinpyrazone
Doxorubicin {u} (Compound) downregulates {v} (Gene) COG2
COG2 {u} (Gene) is regulated by {v} (Gene) ABCC2
ABCC2 {u} (Gene) is bound by {v} (Compound) Sulfinpyrazone
Doxorubicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Sulfinpyrazone (Compound)
Doxorubicin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is upregulated by Sulfinpyrazone (Compound)
Doxorubicin (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Sulfinpyrazone (Compound)
Doxorubicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Paclitaxel (Compound) and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clotrimazole (Compound) and Clotrimazole (Compound) resembles Sulfinpyrazone (Compound)
Doxorubicin (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) is regulated by ABCC5 (Gene) and ABCC5 (Gene) is bound by Sulfinpyrazone (Compound)
Doxorubicin (Compound) upregulates PECR (Gene) and PECR (Gene) is upregulated by Vemurafenib (Compound) and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Doxorubicin (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Gefitinib (Compound) and Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Doxorubicin (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Doxorubicin (Compound) downregulates COG2 (Gene) and COG2 (Gene) is regulated by ABCC2 (Gene) and ABCC2 (Gene) is bound by Sulfinpyrazone (Compound)