DDInter1079 DDInter856
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Lisinopril was granted FDA approval on 29 December 1987.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Lisinopril {u} (Compound) resembles {v} (Compound) Enalapril
Lisinopril {u} (Compound) resembles {v} (Compound) Trandolapril
Lisinopril {u} (Compound) treats {v} (Disease) hypertension
Lisinopril {u} (Compound) binds {v} (Gene) ABCB1
Lisinopril {u} (Compound) downregulates {v} (Gene) ALAS1
Lisinopril {u} (Compound) causes {v} (Side Effect) Inappropriate antidiuretic hormone secretion
Lisinopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Lisinopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Erythropoietin
Lisinopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idelalisib
Lisinopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Urokinase
Lisinopril (Compound) resembles Enalapril (Compound)
Lisinopril (Compound) resembles Trandolapril (Compound)
Lisinopril (Compound) treats hypertension (Disease)
Lisinopril (Compound) binds ABCB1 (Gene)
Lisinopril (Compound) downregulates ALAS1 (Gene)
Lisinopril (Compound) causes Inappropriate antidiuretic hormone secretion (Side Effect)
Lisinopril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Lisinopril may cause a minor interaction that can limit clinical effects when taken with Erythropoietin
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Urokinase