DDInter1421 DDInter535
The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Pentazocine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Pentazocine {u} (Compound) resembles {v} (Compound) Butorphanol
Butorphanol {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) resembles {v} (Compound) Levorphanol
Levorphanol {u} (Compound) upregulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) resembles {v} (Compound) Levorphanol
Levorphanol {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) regulates {v} (Gene) RBM6
RBM6 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is regulated by {v} (Gene) USP22
USP22 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) resembles {v} (Compound) Levorphanol
Levorphanol {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Pentazocine {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Pentazocine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Pentazocine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Pentazocine (Compound) resembles Butorphanol (Compound) and Butorphanol (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Diazoxide (Compound)
Pentazocine (Compound) resembles Levorphanol (Compound) and Levorphanol (Compound) upregulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Pentazocine (Compound) binds EBP (Gene) and EBP (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is upregulated by Diazoxide (Compound)
Pentazocine (Compound) resembles Levorphanol (Compound) and Levorphanol (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Pentazocine (Compound) binds EBP (Gene) and EBP (Gene) regulates RBM6 (Gene) and RBM6 (Gene) is upregulated by Diazoxide (Compound)
Pentazocine (Compound) binds EBP (Gene) and EBP (Gene) is regulated by USP22 (Gene) and USP22 (Gene) is downregulated by Diazoxide (Compound)
Pentazocine (Compound) resembles Levorphanol (Compound) and Levorphanol (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Diazoxide (Compound)
Pentazocine (Compound) binds EBP (Gene) and EBP (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diazoxide (Compound)