DDInter1331 DDInter1082
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and bronchodilation. Activation of the receptor stimulates an associated G protein which then activates adenylate cyclase, catalyzing the formation of cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA). Elevation of these two molecules induces bronchodilation by relaxation of airway smooth muscles. It is by this mechanism that olodaterol is used for the treatment of chronic obstructive pulmonary disease (COPD) and the progressive airflow obstruction that is characteristic of it. Treatment with bronchodilators helps to mitigate associated
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Olodaterol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Olodaterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norfloxacin
Olodaterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lithium carbonate
Olodaterol {u} may lead to a major life threatening interaction when taken with {v} Macimorelin
Olodaterol {u} may lead to a major life threatening interaction when taken with {v} Cocaine
Olodaterol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Olodaterol may lead to a major life threatening interaction when taken with Macimorelin
Olodaterol may lead to a major life threatening interaction when taken with Cocaine