DDInter150 DDInter1492
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Azathioprine {u} (Compound) upregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ponatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) ADAT1
ADAT1 {u} (Gene) regulates {v} (Gene) IL1R2
IL1R2 {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) upregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) FGFR1
FGFR1 {u} (Gene) is bound by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is regulated by {v} (Gene) LYN
LYN {u} (Gene) is bound by {v} (Compound) Ponatinib
Azathioprine {u} (Compound) binds {v} (Gene) HPRT1
HPRT1 {u} (Gene) regulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Ponatinib
Azathioprine (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Ponatinib (Compound)
Azathioprine (Compound) upregulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Ponatinib (Compound)
Azathioprine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Ponatinib (Compound)
Azathioprine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Ponatinib (Compound)
Azathioprine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Ponatinib (Compound)
Azathioprine (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Azathioprine (Compound) upregulates ADAT1 (Gene) and ADAT1 (Gene) regulates IL1R2 (Gene) and IL1R2 (Gene) is upregulated by Ponatinib (Compound)
Azathioprine (Compound) upregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by FGFR1 (Gene) and FGFR1 (Gene) is bound by Ponatinib (Compound)
Azathioprine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is regulated by LYN (Gene) and LYN (Gene) is bound by Ponatinib (Compound)
Azathioprine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) regulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Ponatinib (Compound)