DDInter533 DDInter921
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid. The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is the main enzyme responsible for catalyzes the rate-limiting step in prostaglandin and thromboxane biosynthesis via the arachidonic acid (AA) pathway. Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and Drug Administration in 1965, along with other acetic acid derivatives such as [diclofenac] and [sulindac] that were also developed during the 1960s. Since then, indometacin has been extensively studied in clinical trials as one of the most potent NSAIDs in blocking prostaglandin synthesis and was among the first NSAIDs to be used in the symptomatic treatment of migraine and for headaches that eventually became known as “indomethacin-responsive” headache disorders. Most commonly used in rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis, indometacin is currently available as oral capsules as well as other methods of administration, including rectal and intravenous formulations. Intravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants. Ophthalmic indometacin has been studied and used in the symptomatic treatment of postoperative ocular inflammation and pain and/or complications after cataract surgery. Although deemed effective in reducing ocular inflammation in clinical studies, topical NSAIDs were also associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort, including pain, burning or pricking, or a tingling sensation after instillation into the cul‐de‐sac.
Diatrizoate {u} (Compound) causes {v} (Side Effect) Sweating
Sweating {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Diatrizoate {u} (Compound) causes {v} (Side Effect) Sweating
Sweating {u} (Side Effect) is caused by {v} (Compound) Fenofibrate
Fenofibrate {u} (Compound) resembles {v} (Compound) Indomethacin
Diatrizoate {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Bezafibrate
Bezafibrate {u} (Compound) resembles {v} (Compound) Indomethacin
Diatrizoate {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Cyclophosphamide
Cyclophosphamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Indomethacin
Diatrizoate {u} (Compound) causes {v} (Side Effect) Uremia
Uremia {u} (Side Effect) is caused by {v} (Compound) Vancomycin
Vancomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Iodipamide {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Indomethacin
Diatrizoate {u} (Compound) causes {v} (Side Effect) Uremia
Uremia {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Indomethacin
Diatrizoate {u} (Compound) causes {v} (Side Effect) Disseminated intravascular coagulation
Disseminated intravascular coagulation {u} (Side Effect) is caused by {v} (Compound) Argatroban
Argatroban {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Diatrizoate {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iohexol
Iohexol {u} may lead to a major life threatening interaction when taken with {v} Indomethacin
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Iodipamide {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Diatrizoate (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Indomethacin (Compound)
Diatrizoate (Compound) causes Sweating (Side Effect) and Sweating (Side Effect) is caused by Fenofibrate (Compound) and Fenofibrate (Compound) resembles Indomethacin (Compound)
Diatrizoate (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Bezafibrate (Compound) and Bezafibrate (Compound) resembles Indomethacin (Compound)
Diatrizoate (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Cyclophosphamide (Compound) and Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Indomethacin
Diatrizoate (Compound) causes Uremia (Side Effect) and Uremia (Side Effect) is caused by Vancomycin (Compound) and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin
Diatrizoate (Compound) resembles Iodipamide (Compound) and Iodipamide (Compound) binds ALB (Gene) and ALB (Gene) is bound by Indomethacin (Compound)
Diatrizoate (Compound) causes Uremia (Side Effect) and Uremia (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Indomethacin
Diatrizoate (Compound) causes Disseminated intravascular coagulation (Side Effect) and Disseminated intravascular coagulation (Side Effect) is caused by Argatroban (Compound) and Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin
Diatrizoate (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iohexol (Compound) and Iohexol may lead to a major life threatening interaction when taken with Indomethacin
Diatrizoate (Compound) resembles Iodipamide (Compound) and Iodipamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Indomethacin (Compound)