DDInter544 DDInter1008
A dideoxynucleoside compound in which the 3&#39;-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations.
Didanosine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Itraconazole
Itraconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Didanosine {u} (Compound) causes {v} (Side Effect) Dry eye
Dry eye {u} (Side Effect) is caused by {v} (Compound) Posaconazole
Posaconazole {u} (Compound) resembles {v} (Compound) Ketoconazole
Didanosine {u} (Compound) resembles {v} (Compound) Entecavir
Entecavir {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) resembles {v} (Compound) Zalcitabine
Zalcitabine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) upregulates {v} (Gene) SQLE
SQLE {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) regulates {v} (Gene) ALAS1
ALAS1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) is regulated by {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) regulates {v} (Gene) PPP2R3C
PPP2R3C {u} (Gene) is downregulated by {v} (Compound) Ketoconazole
Didanosine {u} (Compound) upregulates {v} (Gene) ME2
ME2 {u} (Gene) is regulated by {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Ketoconazole
Didanosine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Ketoconazole (Compound)
Didanosine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Itraconazole (Compound) and Itraconazole (Compound) resembles Ketoconazole (Compound)
Didanosine (Compound) causes Dry eye (Side Effect) and Dry eye (Side Effect) is caused by Posaconazole (Compound) and Posaconazole (Compound) resembles Ketoconazole (Compound)
Didanosine (Compound) resembles Entecavir (Compound) and Entecavir (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Ketoconazole (Compound)
Didanosine (Compound) resembles Zalcitabine (Compound) and Zalcitabine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ketoconazole (Compound)
Didanosine (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) upregulates SQLE (Gene) and SQLE (Gene) is upregulated by Ketoconazole (Compound)
Didanosine (Compound) binds PNP (Gene) and PNP (Gene) regulates ALAS1 (Gene) and ALAS1 (Gene) is upregulated by Ketoconazole (Compound)
Didanosine (Compound) binds PNP (Gene) and PNP (Gene) is regulated by HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Ketoconazole (Compound)
Didanosine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) regulates PPP2R3C (Gene) and PPP2R3C (Gene) is downregulated by Ketoconazole (Compound)
Didanosine (Compound) upregulates ME2 (Gene) and ME2 (Gene) is regulated by DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Ketoconazole (Compound)