DDInter395 DDInter1960
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Clemastine {u} (Compound) resembles {v} (Compound) Eletriptan
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Clemastine {u} (Compound) resembles {v} (Compound) Mesoridazine
Clemastine {u} (Compound) binds {v} (Gene) CYP3A4
Clemastine {u} (Compound) upregulates {v} (Gene) INSIG1
Clemastine {u} (Compound) downregulates {v} (Gene) IKBKAP
Clemastine {u} (Compound) causes {v} (Side Effect) Chest tightness
Clemastine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trospium
Clemastine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Clemastine (Compound) resembles Eletriptan (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clemastine (Compound) resembles Mesoridazine (Compound)
Clemastine (Compound) binds CYP3A4 (Gene)
Clemastine (Compound) upregulates INSIG1 (Gene)
Clemastine (Compound) downregulates IKBKAP (Gene)
Clemastine (Compound) causes Chest tightness (Side Effect)
Clemastine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Trospium
Clemastine may lead to a major life threatening interaction when taken with Zonisamide