DDInter477 DDInter952
Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal tryptophan covalently bonded to decanoic acid.[A231374, L32534] Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil samples from Mount Ararat in Turkey. Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed d
2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound.
Iobenguane {u} (Compound) binds {v} (Gene) SLC6A2
Iobenguane {u} (Compound) upregulates {v} (Gene) MCOLN1
Iobenguane {u} (Compound) downregulates {v} (Gene) TXNDC9
Iobenguane {u} (Compound) causes {v} (Side Effect) Dermatitis
Iobenguane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ganciclovir
Iobenguane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Iobenguane {u} may lead to a major life threatening interaction when taken with {v} Human botulinum neurotoxin A/B immune globulin
Iobenguane {u} may lead to a major life threatening interaction when taken with {v} Timolol
Iobenguane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Dextroamphetamine
Iobenguane {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Levomilnacipran
Iobenguane (Compound) binds SLC6A2 (Gene)
Iobenguane (Compound) upregulates MCOLN1 (Gene)
Iobenguane (Compound) downregulates TXNDC9 (Gene)
Iobenguane (Compound) causes Dermatitis (Side Effect)
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Iobenguane may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Iobenguane may lead to a major life threatening interaction when taken with Timolol
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Dextroamphetamine and Iobenguane may lead to a major life threatening interaction when taken with Dextroamphetamine
Iobenguane may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Iobenguane may lead to a major life threatening interaction when taken with Levomilnacipran