DDInter268 DDInter432
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to (vitamin D3) in the skin, which is then converted to in the liver and kidneys. undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity. Calcitriol is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH
Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may lead to a major life threatening interaction when taken with {v} Doxercalciferol
Doxercalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) resembles {v} (Compound) Dihydrotachysterol
Dihydrotachysterol {u} may lead to a major life threatening interaction when taken with {v} Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) resembles {v} (Compound) Cholecalciferol
Cholecalciferol {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Calcifediol
Calcifediol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) resembles {v} (Compound) Calcifediol
Calcifediol {u} may lead to a major life threatening interaction when taken with {v} Paricalcitol
Paricalcitol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol {u} (Compound) resembles {v} (Compound) Ergocalciferol
Ergocalciferol {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Dihydrotachysterol
Dihydrotachysterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colesevelam
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may lead to a major life threatening interaction when taken with Doxercalciferol and Doxercalciferol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) resembles Dihydrotachysterol (Compound) and Dihydrotachysterol may lead to a major life threatening interaction when taken with Calcifediol and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) resembles Cholecalciferol (Compound) and Cholecalciferol (Compound) resembles Calcifediol (Compound) and Cholecalciferol may lead to a major life threatening interaction when taken with Calcifediol and Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) resembles Calcifediol (Compound) and Calcifediol may lead to a major life threatening interaction when taken with Paricalcitol and Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam
Calcitriol (Compound) resembles Ergocalciferol (Compound) and Ergocalciferol (Compound) resembles Dihydrotachysterol (Compound) and Ergocalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol and Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Colesevelam