DDInter1143 DDInter856
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201]
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Meloxicam {u} (Compound) resembles {v} (Compound) Piroxicam
Meloxicam {u} (Compound) binds {v} (Gene) CYP2C9
Meloxicam {u} (Compound) palliates {v} (Disease) systemic lupus erythematosus
Meloxicam {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Meloxicam {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Meloxicam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Meloxicam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lumacaftor
Meloxicam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegaspargase
Meloxicam {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Meloxicam {u} may lead to a major life threatening interaction when taken with {v} Prasugrel
Meloxicam (Compound) resembles Piroxicam (Compound)
Meloxicam (Compound) binds CYP2C9 (Gene)
Meloxicam (Compound) palliates systemic lupus erythematosus (Disease)
Meloxicam (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Meloxicam (Compound) causes Stevens-Johnson syndrome (Side Effect)
Meloxicam may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase
Meloxicam may lead to a major life threatening interaction when taken with Warfarin
Meloxicam may lead to a major life threatening interaction when taken with Prasugrel