DDInter1233 DDInter1917
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Vandetanib
Mitotane {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Erlotinib
Erlotinib {u} (Compound) resembles {v} (Compound) Vandetanib
Mitotane {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Esomeprazole
Esomeprazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vandetanib
Mitotane {u} (Compound) causes {v} (Side Effect) Balance disorder
Balance disorder {u} (Side Effect) is caused by {v} (Compound) Aripiprazole
Aripiprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vandetanib
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vandetanib
Mitotane {u} (Compound) causes {v} (Side Effect) Balance disorder
Balance disorder {u} (Side Effect) is caused by {v} (Compound) Dalfampridine
Dalfampridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vandetanib
Mitotane {u} (Compound) resembles {v} (Compound) Delorazepam
Delorazepam {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) downregulates {v} (Gene) VEGFA
VEGFA {u} (Gene) is bound by {v} (Compound) Vandetanib
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Vandetanib
Mitotane {u} (Compound) resembles {v} (Compound) Delorazepam
Delorazepam {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Vandetanib (Compound)
Mitotane (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Erlotinib (Compound) and Erlotinib (Compound) resembles Vandetanib (Compound)
Mitotane (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Esomeprazole (Compound) and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Vandetanib
Mitotane (Compound) causes Balance disorder (Side Effect) and Balance disorder (Side Effect) is caused by Aripiprazole (Compound) and Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib
Mitotane (Compound) causes Balance disorder (Side Effect) and Balance disorder (Side Effect) is caused by Dalfampridine (Compound) and Dalfampridine may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib
Mitotane (Compound) resembles Delorazepam (Compound) and Delorazepam (Compound) resembles Clozapine (Compound) and Clozapine may lead to a major life threatening interaction when taken with Vandetanib
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) downregulates VEGFA (Gene) and VEGFA (Gene) is bound by Vandetanib (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Vandetanib (Compound)
Mitotane (Compound) resembles Delorazepam (Compound) and Delorazepam (Compound) resembles Amoxapine (Compound) and Amoxapine may lead to a major life threatening interaction when taken with Vandetanib