DDInter1185 DDInter1840
Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading to the inhibition of adrenergic neuronal outflow and reduction of vasoconstrictor adrenergic signals. Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. First introduced in 1960 as an antihypertensive agent, methyldopa was considered to be useful in certain patient populations, such as pregnant women and patients with renal insufficiency. Since
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Methyldopa {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) upregulates {v} (Gene) RPP38
RPP38 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) downregulates {v} (Gene) PRKCH
PRKCH {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is associated with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) downregulates {v} (Gene) RALA
RALA {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) downregulates {v} (Gene) PPARG
PPARG {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) upregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) downregulates {v} (Gene) ERBB3
ERBB3 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa {u} (Compound) resembles {v} (Compound) Aminosalicylic acid
Aminosalicylic acid {u} (Compound) binds {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Trabectedin
Methyldopa (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Trabectedin (Compound)
Methyldopa (Compound) upregulates RPP38 (Gene) and RPP38 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) downregulates PRKCH (Gene) and PRKCH (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) treats hypertension (Disease) and hypertension (Disease) is associated with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) downregulates RALA (Gene) and RALA (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) downregulates PPARG (Gene) and PPARG (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) upregulates SLC5A6 (Gene) and SLC5A6 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) downregulates ERBB3 (Gene) and ERBB3 (Gene) interacts with SRC (Gene) and ERBB3 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Methyldopa (Compound) resembles Aminosalicylic acid (Compound) and Aminosalicylic acid (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Trabectedin (Compound)