DDInter604 DDInter437
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thrombo
C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within these pathways including activated C1s, kallikrein, factor XIIa and factor XIa. C1 esterase inhibitor has also been shown to inhibit the action of thrombin within the coagulation pathway, and tPA and plasmin within the fibrinolytic pathway. Deficiency of C1-inhibitor allows for increased plasma kallikrein activation and subsequent production of bradykinin. Additionally, C4 and C2 cleavage occurs resulting in auto-activation of the complement system. Down-stream effects of the lack of enzyme inhibition by C1 esterase inhibitor results in swelling due to leakage of fluid from blood vessels into connective tissue and consequently the presentation of hereditary angioedema (HAE). Marketed as the product Ruconest (FDA), this drug is indicated for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults. Intravenous replacement of C1 esterase inhibitor results in reversal of acute symptoms of HAE.
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} (Compound) resembles {v} (Compound) Estrone
Estrone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) causes {v} (Side Effect) Thromboembolic event
Thromboembolic event {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} may lead to a major life threatening interaction when taken with {v} Conestat alfa
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Carfilzomib {u} may lead to a major life threatening interaction when taken with {v} Conestat alfa
Drospirenone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Oxandrolone
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) binds {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Oxandrolone
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxandrolone
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mestranol
Mestranol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conestat alfa
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Testosterone (Compound) and Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Toremifene (Compound) and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Estrone (Compound) and Estrone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) causes Thromboembolic event (Side Effect) and Thromboembolic event (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide may lead to a major life threatening interaction when taken with Conestat alfa
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Conestat alfa
Drospirenone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Oxandrolone (Compound) and Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) binds AR (Gene) and AR (Gene) is bound by Oxandrolone (Compound) and Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Drospirenone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa