DDInter1447 DDInter1311
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levonordefrin
Levonordefrin {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Norepinephrine
Phentermine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Norepinephrine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epinephrine
Epinephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methyldopa
Methyldopa {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levonordefrin
Levonordefrin {u} (Compound) resembles {v} (Compound) Methyldopa
Methyldopa {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methyldopa
Methyldopa {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Droxidopa
Droxidopa {u} (Compound) resembles {v} (Compound) Methyldopa
Methyldopa {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Levonordefrin
Levonordefrin {u} (Compound) resembles {v} (Compound) Norepinephrine
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine (Compound) resembles Norepinephrine (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin and Levonordefrin (Compound) resembles Norepinephrine (Compound)
Phentermine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Norepinephrine (Compound)
Phentermine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Norepinephrine (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa (Compound) resembles Norepinephrine (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin and Levonordefrin (Compound) resembles Methyldopa (Compound) and Methyldopa (Compound) resembles Norepinephrine (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Methyldopa and Methyldopa (Compound) resembles Norepinephrine (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Droxidopa and Droxidopa (Compound) resembles Methyldopa (Compound) and Methyldopa (Compound) resembles Norepinephrine (Compound)
Phentermine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Epinephrine (Compound) and Epinephrine (Compound) resembles Norepinephrine (Compound)
Phentermine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Levonordefrin (Compound) and Levonordefrin (Compound) resembles Norepinephrine (Compound)