DDInter1700 DDInter1658
Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural disposition of short stature should be considered a medical condition justifying medical treatment with such hormone therapy - especially when these hormone agents have been proven effective at increasing the height of children with or without growth hormone deficiency.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Somatrem {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fostemsavir
Somatrem {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lidocaine
Somatrem {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvastatin
Somatrem {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Larotrectinib
Somatrem {u} may lead to a major life threatening interaction when taken with {v} Bexarotene
Somatrem may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Somatrem may cause a minor interaction that can limit clinical effects when taken with Lidocaine
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Somatrem may lead to a major life threatening interaction when taken with Bexarotene