DDInter1233 DDInter716
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is downregulated by {v} (Compound) Felodipine
Mitotane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Felodipine
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Felodipine
Mitotane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Felodipine
Mitotane {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Theophylline
Theophylline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Felodipine
Mitotane {u} (Compound) causes {v} (Side Effect) Hepatitis cholestatic
Hepatitis cholestatic {u} (Side Effect) is caused by {v} (Compound) Clarithromycin
Clarithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Felodipine
Mitotane {u} (Compound) causes {v} (Side Effect) Anaemia
Anaemia {u} (Side Effect) is caused by {v} (Compound) Isradipine
Isradipine {u} (Compound) resembles {v} (Compound) Felodipine
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Felodipine
Mitotane {u} (Compound) downregulates {v} (Gene) GJA1
GJA1 {u} (Gene) is regulated by {v} (Gene) CACNA1C
CACNA1C {u} (Gene) is bound by {v} (Compound) Felodipine
Mitotane {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Felodipine
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Felodipine (Compound)
Mitotane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Felodipine (Compound)
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Felodipine (Compound)
Mitotane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Amlodipine (Compound) and Amlodipine (Compound) resembles Felodipine (Compound)
Mitotane (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Theophylline (Compound) and Theophylline may cause a minor interaction that can limit clinical effects when taken with Felodipine
Mitotane (Compound) causes Hepatitis cholestatic (Side Effect) and Hepatitis cholestatic (Side Effect) is caused by Clarithromycin (Compound) and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Felodipine
Mitotane (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Isradipine (Compound) and Isradipine (Compound) resembles Felodipine (Compound)
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Felodipine (Compound)
Mitotane (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is regulated by CACNA1C (Gene) and CACNA1C (Gene) is bound by Felodipine (Compound)
Mitotane (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Felodipine