DDInter458 DDInter911
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include [meropenem], known for having greater activity against Gram negative bacteria, and the newer [ertapenem] which exhibits a longer half-life due to increased binding to plasma proteins. Imipenem is commonly used in combination with [cilastatin] and is now available in a triple-drug product with cilastatin and [relebactam] which was recently approved by the FDA. Imipenem was first approved by the FDA in November 1985 as the combination product Primaxin marketed by Merck & Co.
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) downregulates {v} (Gene) ITGAE
ITGAE {u} (Gene) is downregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) regulates {v} (Gene) TATDN2
TATDN2 {u} (Gene) is upregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) downregulates {v} (Gene) ITGAE
ITGAE {u} (Gene) is downregulated by {v} (Compound) Iohexol
Iohexol {u} may lead to a major life threatening interaction when taken with {v} Imipenem
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Imipenem
Cyclosporine {u} (Compound) downregulates {v} (Gene) POLD1
POLD1 {u} (Gene) regulates {v} (Gene) TATDN2
TATDN2 {u} (Gene) is upregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) regulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) upregulates {v} (Gene) TP53
TP53 {u} (Gene) interacts with {v} (Gene) CEBPB
CEBPB {u} (Gene) is downregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is regulated by {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Imipenem
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is regulated by {v} (Gene) ITGAE
ITGAE {u} (Gene) is downregulated by {v} (Compound) Imipenem
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Imipenem (Compound)
Cyclosporine (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Imipenem (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) regulates TATDN2 (Gene) and TATDN2 (Gene) is upregulated by Imipenem (Compound)
Cyclosporine (Compound) downregulates ITGAE (Gene) and ITGAE (Gene) is downregulated by Iohexol (Compound) and Iohexol may lead to a major life threatening interaction when taken with Imipenem
Cyclosporine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Mycophenolic acid (Compound) and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Imipenem
Cyclosporine (Compound) downregulates POLD1 (Gene) and POLD1 (Gene) regulates TATDN2 (Gene) and TATDN2 (Gene) is upregulated by Imipenem (Compound)
Cyclosporine (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) regulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Imipenem (Compound)
Cyclosporine (Compound) upregulates TP53 (Gene) and TP53 (Gene) interacts with CEBPB (Gene) and CEBPB (Gene) is downregulated by Imipenem (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is regulated by TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Imipenem (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is regulated by ITGAE (Gene) and ITGAE (Gene) is downregulated by Imipenem (Compound)