DDInter458 DDInter32
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations as detected by an FDA-approved test . Gilotrif (afatinib) is the first FDA-approved oncology product from Boehringer Ingelheim .
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) downregulates {v} (Gene) ZWINT
ZWINT {u} (Gene) is downregulated by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) COPB2
COPB2 {u} (Gene) is downregulated by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Afatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Afatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is regulated by {v} (Gene) PHKG2
PHKG2 {u} (Gene) is bound by {v} (Compound) Afatinib
Cyclosporine {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is regulated by {v} (Gene) KEAP1
KEAP1 {u} (Gene) is upregulated by {v} (Compound) Afatinib
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Afatinib (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Afatinib (Compound)
Cyclosporine (Compound) downregulates ZWINT (Gene) and ZWINT (Gene) is downregulated by Afatinib (Compound)
Cyclosporine (Compound) upregulates COPB2 (Gene) and COPB2 (Gene) is downregulated by Afatinib (Compound)
Cyclosporine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Afatinib (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Gefitinib (Compound) and Gefitinib (Compound) resembles Afatinib (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Gefitinib (Compound) and Gefitinib (Compound) resembles Afatinib (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is regulated by PHKG2 (Gene) and PHKG2 (Gene) is bound by Afatinib (Compound)
Cyclosporine (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is regulated by KEAP1 (Gene) and KEAP1 (Gene) is upregulated by Afatinib (Compound)