DDInter576 DDInter1377
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) downregulates {v} (Gene) PPP2R5A
PPP2R5A {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) downregulates {v} (Gene) LIG1
LIG1 {u} (Gene) is downregulated by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) upregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatic necrosis
Hepatic necrosis {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) upregulates {v} (Gene) TUBB6
TUBB6 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paclitaxel
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Paclitaxel
Disulfiram {u} (Compound) downregulates {v} (Gene) PPP2R5A
PPP2R5A {u} (Gene) interacts with {v} (Gene) BCL2
BCL2 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Disulfiram (Compound) downregulates PPP2R5A (Gene) and PPP2R5A (Gene) is upregulated by Paclitaxel (Compound)
Disulfiram (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Paclitaxel (Compound)
Disulfiram (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is downregulated by Paclitaxel (Compound)
Disulfiram (Compound) upregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Paclitaxel (Compound)
Disulfiram (Compound) causes Hepatic necrosis (Side Effect) and Hepatic necrosis (Side Effect) is caused by Paclitaxel (Compound)
Disulfiram (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Paclitaxel (Compound) and TUBB6 (Gene) is upregulated by Paclitaxel (Compound)
Disulfiram (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Paclitaxel
Disulfiram (Compound) downregulates PPP2R5A (Gene) and PPP2R5A (Gene) interacts with BCL2 (Gene) and BCL2 (Gene) is bound by Paclitaxel (Compound)