DDInter557 DDInter513
A 9,10alpha-dihydro derivative of [ergotamine]. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile. Recent improvements have been made in the design of intranasal delivery devices allowing for greater delivery of dihydroergotamine solution to the vasculature-rich upper nasal cavity. The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution formulated at 75% of the strength of the existing intranasal product.
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) TNFRSF21
TNFRSF21 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Trauma
Trauma {u} (Side Effect) is caused by {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) resembles {v} (Compound) Ergotamine
Ergotamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Dihydroergotamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) TNFRSF21
TNFRSF21 {u} (Gene) is downregulated by {v} (Compound) Budesonide
Budesonide {u} (Compound) resembles {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) downregulates {v} (Gene) CTNND1
CTNND1 {u} (Gene) is downregulated by {v} (Compound) Betamethasone
Betamethasone {u} (Compound) resembles {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Trauma
Trauma {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Fludrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Dihydroergotamine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Dexamethasone
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dexamethasone (Compound)
Dihydroergotamine (Compound) downregulates TNFRSF21 (Gene) and TNFRSF21 (Gene) is downregulated by Dexamethasone (Compound)
Dihydroergotamine (Compound) causes Trauma (Side Effect) and Trauma (Side Effect) is caused by Dexamethasone (Compound)
Dihydroergotamine (Compound) resembles Ergotamine (Compound) and Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone
Dihydroergotamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Dihydroergotamine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Dexamethasone (Compound)
Dihydroergotamine (Compound) downregulates TNFRSF21 (Gene) and TNFRSF21 (Gene) is downregulated by Budesonide (Compound) and Budesonide (Compound) resembles Dexamethasone (Compound)
Dihydroergotamine (Compound) downregulates CTNND1 (Gene) and CTNND1 (Gene) is downregulated by Betamethasone (Compound) and Betamethasone (Compound) resembles Dexamethasone (Compound)
Dihydroergotamine (Compound) causes Trauma (Side Effect) and Trauma (Side Effect) is caused by Fludrocortisone (Compound) and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Dihydroergotamine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Dexamethasone (Compound)