DDInter1158 DDInter533
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Mesalazine {u} (Compound) causes {v} (Side Effect) Nephrotic syndrome
Nephrotic syndrome {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Mesalazine {u} (Compound) causes {v} (Side Effect) Chills
Chills {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Iodipamide {u} (Compound) resembles {v} (Compound) Diatrizoate
Mesalazine {u} (Compound) upregulates {v} (Gene) TMEM110
TMEM110 {u} (Gene) is upregulated by {v} (Compound) Metrizamide
Metrizamide {u} (Compound) resembles {v} (Compound) Diatrizoate
Mesalazine {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Metrizamide
Metrizamide {u} (Compound) resembles {v} (Compound) Diatrizoate
Mesalazine {u} (Compound) resembles {v} (Compound) Salicylate-sodium
Salicylate-sodium {u} (Compound) causes {v} (Side Effect) Creatinine increased
Creatinine increased {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Mesalazine {u} (Compound) resembles {v} (Compound) Diflunisal
Diflunisal {u} (Compound) causes {v} (Side Effect) Nephrotic syndrome
Nephrotic syndrome {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Mesalazine (Compound) causes Nephrotic syndrome (Side Effect) and Nephrotic syndrome (Side Effect) is caused by Diatrizoate (Compound)
Mesalazine (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Iodipamide (Compound) and Iodipamide (Compound) resembles Diatrizoate (Compound)
Mesalazine (Compound) upregulates TMEM110 (Gene) and TMEM110 (Gene) is upregulated by Metrizamide (Compound) and Metrizamide (Compound) resembles Diatrizoate (Compound)
Mesalazine (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Metrizamide (Compound) and Metrizamide (Compound) resembles Diatrizoate (Compound)
Mesalazine (Compound) resembles Salicylate-sodium (Compound) and Salicylate-sodium (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Diatrizoate (Compound)
Mesalazine (Compound) resembles Diflunisal (Compound) and Diflunisal (Compound) causes Nephrotic syndrome (Side Effect) and Nephrotic syndrome (Side Effect) is caused by Diatrizoate (Compound)