DDInter150 DDInter1890
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodendron_ and _Strychnos_. Tubocurarine is a benzylisoquinoline derivative and shares this structural backbone with a number of plant-derived alkaloids, including [morphine] and [papaverine]. It was first isolated by Harold King in 1935 and was used clinically to induce neuromuscular blockade during surgeries, particularly those involving the abdomen. Tubocurarine's clinical use was limited by its relatively long duration of action (30-60 minutes) and a number of significant side effects. Safer and more pharmacokinetically favorable non-depolarizing neuromuscular blockers, such as [rocuronium], have largely replaced the use of tubocurarine in the clinical setting.
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) upregulates {v} (Gene) ADAT1
ADAT1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) EXOSC4
EXOSC4 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) regulates {v} (Gene) VPS28
VPS28 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) downregulates {v} (Gene) SLC5A6
SLC5A6 {u} (Gene) regulates {v} (Gene) PMM2
PMM2 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is regulated by {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Azathioprine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tubocurarine
Azathioprine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is regulated by {v} (Gene) EXOSC4
EXOSC4 {u} (Gene) is downregulated by {v} (Compound) Tubocurarine
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Tubocurarine (Compound)
Azathioprine (Compound) upregulates ADAT1 (Gene) and ADAT1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Tubocurarine (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by SESN1 (Gene) and SESN1 (Gene) is upregulated by Tubocurarine (Compound)
Azathioprine (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Tubocurarine (Compound)
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by EXOSC4 (Gene) and EXOSC4 (Gene) is downregulated by Tubocurarine (Compound)
Azathioprine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) regulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Tubocurarine (Compound)
Azathioprine (Compound) downregulates SLC5A6 (Gene) and SLC5A6 (Gene) regulates PMM2 (Gene) and PMM2 (Gene) is downregulated by Tubocurarine (Compound)
Azathioprine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is regulated by C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Tubocurarine (Compound)
Azathioprine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Tubocurarine
Azathioprine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is regulated by EXOSC4 (Gene) and EXOSC4 (Gene) is downregulated by Tubocurarine (Compound)