DDInter601 DDInter1845
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. Due to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA Label]. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Tranylcypromine
Dronabinol {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Tranylcypromine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Phenmetrazine
Phenmetrazine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenelzine
Phenelzine {u} may lead to a major life threatening interaction when taken with {v} Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Phentermine
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Tranylcypromine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Tranylcypromine (Compound)
Dronabinol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tranylcypromine (Compound)
Dronabinol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Tranylcypromine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Phenmetrazine (Compound) and Phenmetrazine (Compound) resembles Tranylcypromine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound) and Ethotoin (Compound) resembles Tranylcypromine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine may lead to a major life threatening interaction when taken with Phentermine and Phentermine (Compound) resembles Tranylcypromine (Compound)
Dronabinol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ethotoin (Compound) and Ethotoin (Compound) resembles Tranylcypromine (Compound)
Dronabinol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)
Dronabinol (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Phentermine (Compound) and Phentermine (Compound) resembles Tranylcypromine (Compound)