DDInter456 DDInter178
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Cyclophosphamide {u} (Compound) resembles {v} (Compound) Mechlorethamine
Cyclophosphamide {u} (Compound) binds {v} (Gene) CYP3A4
Cyclophosphamide {u} (Compound) downregulates {v} (Gene) ENOPH1
Cyclophosphamide {u} (Compound) causes {v} (Side Effect) Impaired healing
Cyclophosphamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Cyclophosphamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginterferon alfa-2a
Cyclophosphamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mitomycin
Cyclophosphamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lorlatinib
Cyclophosphamide {u} may lead to a major life threatening interaction when taken with {v} Golimumab
Cyclophosphamide {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cyclophosphamide (Compound) resembles Mechlorethamine (Compound)
Cyclophosphamide (Compound) binds CYP3A4 (Gene)
Cyclophosphamide (Compound) downregulates ENOPH1 (Gene)
Cyclophosphamide (Compound) causes Impaired healing (Side Effect)
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Modafinil
Cyclophosphamide may cause a minor interaction that can limit clinical effects when taken with Peginterferon alfa-2a
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin
Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Cyclophosphamide may lead to a major life threatening interaction when taken with Golimumab
Cyclophosphamide may lead to a major life threatening interaction when taken with Cladribine