DDInter1263 DDInter1658
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Naltrexone {u} may lead to a major life threatening interaction when taken with {v} Oxycodone
Naltrexone {u} (Compound) resembles {v} (Compound) Hydrocodone
Naltrexone {u} (Compound) resembles {v} (Compound) Butorphanol
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
Naltrexone {u} (Compound) binds {v} (Gene) OPRD1
Naltrexone {u} (Compound) upregulates {v} (Gene) TSC22D3
Naltrexone {u} (Compound) is included by {v} (Pharmacologic Class) Opioid Antagonists
Naltrexone {u} (Compound) downregulates {v} (Gene) IER3
Naltrexone {u} (Compound) causes {v} (Side Effect) Dyspnoea
Naltrexone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorzoxazone
Naltrexone may lead to a major life threatening interaction when taken with Oxycodone
Naltrexone (Compound) resembles Hydrocodone (Compound)
Naltrexone (Compound) resembles Butorphanol (Compound)
Naltrexone (Compound) treats alcohol dependence (Disease)
Naltrexone (Compound) binds OPRD1 (Gene)
Naltrexone (Compound) upregulates TSC22D3 (Gene)
Naltrexone (Compound) is included by Opioid Antagonists (Pharmacologic Class)
Naltrexone (Compound) downregulates IER3 (Gene)
Naltrexone (Compound) causes Dyspnoea (Side Effect)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Chlorzoxazone