DDInter1042 DDInter363
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Chlorpromazine {u} (Compound) resembles {v} (Compound) Prochlorperazine
Chlorpromazine {u} (Compound) resembles {v} (Compound) Ethopropazine
Chlorpromazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Chlorpromazine {u} (Compound) binds {v} (Gene) HTR2C
Chlorpromazine {u} (Compound) upregulates {v} (Gene) AARS
Chlorpromazine {u} (Compound) palliates {v} (Disease) bipolar disorder
Chlorpromazine {u} (Compound) is included by {v} (Pharmacologic Class) Phenothiazines
Chlorpromazine {u} (Compound) downregulates {v} (Gene) EED
Chlorpromazine {u} (Compound) causes {v} (Side Effect) Convulsion
Chlorpromazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium oxide
Chlorpromazine (Compound) resembles Prochlorperazine (Compound)
Chlorpromazine (Compound) resembles Ethopropazine (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Chlorpromazine (Compound) binds HTR2C (Gene)
Chlorpromazine (Compound) upregulates AARS (Gene)
Chlorpromazine (Compound) palliates bipolar disorder (Disease)
Chlorpromazine (Compound) is included by Phenothiazines (Pharmacologic Class)
Chlorpromazine (Compound) downregulates EED (Gene)
Chlorpromazine (Compound) causes Convulsion (Side Effect)
Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide