DDInter292 DDInter1376
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Captopril {u} (Compound) resembles {v} (Compound) Enalapril
Captopril {u} (Compound) treats {v} (Disease) coronary artery disease
Captopril {u} (Compound) binds {v} (Gene) MMP2
Captopril {u} (Compound) upregulates {v} (Gene) RELB
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
Captopril {u} (Compound) causes {v} (Side Effect) Diabetic
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium citrate
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darbepoetin alfa
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin lispro
Captopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glulisine
Captopril (Compound) resembles Enalapril (Compound)
Captopril (Compound) treats coronary artery disease (Disease)
Captopril (Compound) binds MMP2 (Gene)
Captopril (Compound) upregulates RELB (Gene)
Captopril (Compound) downregulates NPC1 (Gene)
Captopril (Compound) causes Diabetic (Side Effect)
Captopril may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Captopril may cause a minor interaction that can limit clinical effects when taken with Darbepoetin alfa
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine