DDInter1244 DDInter1376
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Hydromorphone
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Naloxone
Morphine {u} (Compound) resembles {v} (Compound) Hydrocodone
Morphine {u} (Compound) binds {v} (Gene) UGT2B7
Morphine {u} (Compound) palliates {v} (Disease) coronary artery disease
Morphine {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Morphine {u} (Compound) causes {v} (Side Effect) Faecalith
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ephedrine
Morphine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Salmon calcitonin
Morphine (Compound) resembles Galantamine (Compound)
Morphine may lead to a major life threatening interaction when taken with Hydromorphone
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone
Morphine (Compound) resembles Hydrocodone (Compound)
Morphine (Compound) binds UGT2B7 (Gene)
Morphine (Compound) palliates coronary artery disease (Disease)
Morphine (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Morphine (Compound) causes Faecalith (Side Effect)
Morphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine
Morphine may cause a minor interaction that can limit clinical effects when taken with Salmon calcitonin