DDInter1570 DDInter93
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythemia treatments (e.g. [busulfan], [hydroxyurea]) and may be better tolerated.
Ranolazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is upregulated by {v} (Compound) Anagrelide
Ranolazine {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Anagrelide
Ranolazine {u} (Compound) resembles {v} (Compound) Carvedilol
Carvedilol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anagrelide
Ranolazine {u} (Compound) upregulates {v} (Gene) NR1H2
NR1H2 {u} (Gene) is regulated by {v} (Gene) RHOA
RHOA {u} (Gene) is upregulated by {v} (Compound) Anagrelide
Ranolazine {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anagrelide
Ranolazine {u} (Compound) causes {v} (Side Effect) Pulmonary fibrosis
Pulmonary fibrosis {u} (Side Effect) is caused by {v} (Compound) Mexiletine
Mexiletine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anagrelide
Ranolazine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Milrinone
Milrinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anagrelide
Ranolazine {u} (Compound) resembles {v} (Compound) Guaifenesin
Guaifenesin {u} (Compound) resembles {v} (Compound) Carvedilol
Carvedilol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anagrelide
Ranolazine {u} (Compound) resembles {v} (Compound) Carvedilol
Carvedilol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Anagrelide
Ranolazine {u} (Compound) resembles {v} (Compound) Bupivacaine
Bupivacaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anagrelide
Ranolazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Anagrelide (Compound)
Ranolazine (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Anagrelide (Compound)
Ranolazine (Compound) resembles Carvedilol (Compound) and Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide
Ranolazine (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is regulated by RHOA (Gene) and RHOA (Gene) is upregulated by Anagrelide (Compound)
Ranolazine (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Anagrelide
Ranolazine (Compound) causes Pulmonary fibrosis (Side Effect) and Pulmonary fibrosis (Side Effect) is caused by Mexiletine (Compound) and Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide
Ranolazine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Milrinone (Compound) and Milrinone may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide
Ranolazine (Compound) resembles Guaifenesin (Compound) and Guaifenesin (Compound) resembles Carvedilol (Compound) and Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide
Ranolazine (Compound) resembles Carvedilol (Compound) and Carvedilol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Anagrelide (Compound)
Ranolazine (Compound) resembles Bupivacaine (Compound) and Bupivacaine (Compound) resembles Lidocaine (Compound) and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Anagrelide