DDInter576 DDInter1376
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Disulfiram {u} (Compound) treats {v} (Disease) alcohol dependence
Disulfiram {u} (Compound) binds {v} (Gene) DBH
Disulfiram {u} (Compound) upregulates {v} (Gene) FHL2
Disulfiram {u} (Compound) is included by {v} (Pharmacologic Class) Acetyl Aldehyde Dehydrogenase Inhibitors
Disulfiram {u} (Compound) downregulates {v} (Gene) NR2F6
Disulfiram {u} (Compound) causes {v} (Side Effect) Neuropathy
Disulfiram (Compound) treats alcohol dependence (Disease)
Disulfiram (Compound) binds DBH (Gene)
Disulfiram (Compound) upregulates FHL2 (Gene)
Disulfiram (Compound) is included by Acetyl Aldehyde Dehydrogenase Inhibitors (Pharmacologic Class)
Disulfiram (Compound) downregulates NR2F6 (Gene)
Disulfiram (Compound) causes Neuropathy (Side Effect)