DDInter1707 DDInter856
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Spironolactone {u} (Compound) resembles {v} (Compound) Dydrogesterone
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Spironolactone {u} (Compound) treats {v} (Disease) dilated cardiomyopathy
Spironolactone {u} (Compound) binds {v} (Gene) PGR
Spironolactone {u} (Compound) upregulates {v} (Gene) WIF1
Spironolactone {u} (Compound) is included by {v} (Pharmacologic Class) Aldosterone Antagonists
Spironolactone {u} (Compound) downregulates {v} (Gene) GNAS
Spironolactone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Spironolactone (Compound) resembles Testosterone (Compound)
Spironolactone (Compound) resembles Dydrogesterone (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Spironolactone (Compound) treats dilated cardiomyopathy (Disease)
Spironolactone (Compound) binds PGR (Gene)
Spironolactone (Compound) upregulates WIF1 (Gene)
Spironolactone (Compound) is included by Aldosterone Antagonists (Pharmacologic Class)
Spironolactone (Compound) downregulates GNAS (Gene)
Spironolactone (Compound) causes Feeling abnormal (Side Effect)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin