DDInter217 DDInter1662
Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} (Compound) downregulates {v} (Gene) CSRP1
CSRP1 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexfenfluramine
Dexfenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Bromfenac {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Bromfenac {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clomipramine
Clomipramine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Sertraline
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is downregulated by Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Sertraline (Compound)