DDInter416 DDInter1470
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Pimozide
Clotrimazole {u} (Compound) binds {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Pimozide
Clotrimazole {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Pimozide
Clotrimazole {u} (Compound) resembles {v} (Compound) Clofedanol
Clofedanol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pimozide
Clotrimazole {u} (Compound) resembles {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pimozide
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Pimozide
Clotrimazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Fexofenadine
Fexofenadine {u} (Compound) resembles {v} (Compound) Pimozide
Clotrimazole {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pimozide
Clotrimazole {u} (Compound) binds {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Fluspirilene
Fluspirilene {u} (Compound) resembles {v} (Compound) Pimozide
Clotrimazole (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Pimozide (Compound)
Clotrimazole (Compound) binds CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Pimozide (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Pimozide (Compound)
Clotrimazole (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Pimozide (Compound)
Clotrimazole (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Clotrimazole (Compound) resembles Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Clotrimazole (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Pimozide (Compound)
Clotrimazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Fexofenadine (Compound) and Fexofenadine (Compound) resembles Pimozide (Compound)
Clotrimazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Clotrimazole (Compound) binds CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Fluspirilene (Compound) and Fluspirilene (Compound) resembles Pimozide (Compound)