DDInter458 DDInter1009
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Sepsis
Sepsis {u} (Side Effect) is caused by {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Mefenamic acid
Mefenamic acid {u} (Compound) resembles {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) covaries with {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) downregulates {v} (Gene) THAP11
THAP11 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may lead to a major life threatening interaction when taken with {v} Ketoprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Sepsis
Sepsis {u} (Side Effect) is caused by {v} (Compound) Mefenamic acid
Mefenamic acid {u} (Compound) resembles {v} (Compound) Ketoprofen
Cyclosporine {u} (Compound) causes {v} (Side Effect) Migraine
Migraine {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ketoprofen (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Ketoprofen (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Ketoprofen (Compound)
Cyclosporine (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Ketoprofen (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Mefenamic acid (Compound) and Mefenamic acid (Compound) resembles Ketoprofen (Compound)
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) covaries with SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ketoprofen (Compound)
Cyclosporine (Compound) downregulates THAP11 (Gene) and THAP11 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Ketoprofen
Cyclosporine (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Mefenamic acid (Compound) and Mefenamic acid (Compound) resembles Ketoprofen (Compound)
Cyclosporine (Compound) causes Migraine (Side Effect) and Migraine (Side Effect) is caused by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen