DDInter82 DDInter381
Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Amoxapine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Dexfenfluramine {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cinacalcet
Amoxapine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Cinacalcet
Amoxapine {u} may lead to a major life threatening interaction when taken with {v} Dexfenfluramine
Dexfenfluramine {u} may lead to a major life threatening interaction when taken with {v} Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Terbinafine {u} (Compound) resembles {v} (Compound) Propranolol
Propranolol {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Duloxetine
Duloxetine {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Terbinafine
Terbinafine {u} (Compound) resembles {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Cinacalcet
Amoxapine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine (Compound) resembles Cinacalcet (Compound)
Amoxapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cinacalcet (Compound)
Amoxapine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Cinacalcet (Compound)
Amoxapine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine (Compound) resembles Cinacalcet (Compound)
Amoxapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Amoxapine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Amoxapine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine and Terbinafine (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Cinacalcet (Compound)
Amoxapine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Duloxetine (Compound) and Duloxetine (Compound) resembles Cinacalcet (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Terbinafine and Terbinafine (Compound) resembles Naftifine (Compound) and Naftifine (Compound) resembles Cinacalcet (Compound)