DDInter576 DDInter1
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Abacavir
Disulfiram {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Abacavir
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Cladribine
Cladribine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Orlistat
Orlistat {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Abacavir
Disulfiram {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is bound by {v} (Compound) Cladribine
Cladribine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram {u} (Compound) upregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cladribine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram {u} (Compound) downregulates {v} (Gene) POLE2
POLE2 {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram {u} (Compound) upregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram {u} (Compound) upregulates {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Orlistat
Orlistat {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abacavir
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Abacavir (Compound)
Disulfiram (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Nelarabine (Compound) and Nelarabine (Compound) resembles Abacavir (Compound)
Disulfiram (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Cladribine (Compound) and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Disulfiram (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Orlistat (Compound) and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Disulfiram (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Abacavir
Disulfiram (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is bound by Cladribine (Compound) and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Disulfiram (Compound) upregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Cladribine (Compound) and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Disulfiram (Compound) downregulates POLE2 (Gene) and POLE2 (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Disulfiram (Compound) upregulates RGS2 (Gene) and RGS2 (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Disulfiram (Compound) upregulates RELB (Gene) and RELB (Gene) is upregulated by Orlistat (Compound) and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Abacavir