DDInter150 DDInter1144
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem cell transplant. It is also used to treat uveal melanoma with unresectable hepatic metastases.
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Melphalan
Azathioprine {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Levodopa
Levodopa {u} (Compound) resembles {v} (Compound) Melphalan
Azathioprine {u} (Compound) causes {v} (Side Effect) Interstitial lung disease
Interstitial lung disease {u} (Side Effect) is caused by {v} (Compound) Chlorambucil
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Azathioprine {u} (Compound) causes {v} (Side Effect) Non-Hodgkin's lymphoma
Non-Hodgkin's lymphoma {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Azathioprine {u} (Compound) causes {v} (Side Effect) Bone marrow depression
Bone marrow depression {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Azathioprine {u} (Compound) causes {v} (Side Effect) Venoocclusive disease
Venoocclusive disease {u} (Side Effect) is caused by {v} (Compound) Dactinomycin
Dactinomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Azathioprine {u} (Compound) resembles {v} (Compound) Adenine
Adenine {u} (Compound) resembles {v} (Compound) Tioguanine
Tioguanine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Azathioprine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Melphalan
Azathioprine {u} (Compound) causes {v} (Side Effect) Non-Hodgkin's lymphoma
Non-Hodgkin's lymphoma {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Azathioprine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) downregulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is upregulated by {v} (Compound) Melphalan
Azathioprine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Melphalan (Compound)
Azathioprine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Levodopa (Compound) and Levodopa (Compound) resembles Melphalan (Compound)
Azathioprine (Compound) causes Interstitial lung disease (Side Effect) and Interstitial lung disease (Side Effect) is caused by Chlorambucil (Compound) and Chlorambucil (Compound) resembles Melphalan (Compound)
Azathioprine (Compound) causes Non-Hodgkin's lymphoma (Side Effect) and Non-Hodgkin's lymphoma (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Melphalan
Azathioprine (Compound) causes Bone marrow depression (Side Effect) and Bone marrow depression (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Melphalan
Azathioprine (Compound) causes Venoocclusive disease (Side Effect) and Venoocclusive disease (Side Effect) is caused by Dactinomycin (Compound) and Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Melphalan
Azathioprine (Compound) resembles Adenine (Compound) and Adenine (Compound) resembles Tioguanine (Compound) and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan
Azathioprine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Melphalan
Azathioprine (Compound) causes Non-Hodgkin's lymphoma (Side Effect) and Non-Hodgkin's lymphoma (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Melphalan
Azathioprine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) downregulates BLCAP (Gene) and BLCAP (Gene) is upregulated by Melphalan (Compound)