DDInter1008 DDInter1555
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue
The 3-cyclopentyl ether of ethinyl estradiol.
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Mestranol
Mestranol {u} (Compound) resembles {v} (Compound) Quinestrol
Ketoconazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Estramustine
Estramustine {u} (Compound) resembles {v} (Compound) Quinestrol
Ketoconazole {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Estramustine
Estramustine {u} (Compound) resembles {v} (Compound) Quinestrol
Ketoconazole {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Quinestrol
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinestrol
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Anastrozole
Anastrozole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Ketoconazole {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinestrol
Ketoconazole {u} (Compound) causes {v} (Side Effect) Dry skin
Dry skin {u} (Side Effect) is caused by {v} (Compound) Vemurafenib
Vemurafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Ketoconazole {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Anastrozole
Anastrozole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Mestranol (Compound) and Mestranol (Compound) resembles Quinestrol (Compound)
Ketoconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Estramustine (Compound) and Estramustine (Compound) resembles Quinestrol (Compound)
Ketoconazole (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Estramustine (Compound) and Estramustine (Compound) resembles Quinestrol (Compound)
Ketoconazole (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Quinestrol
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Anastrozole (Compound) and Anastrozole may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol
Ketoconazole (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a minor interaction that can limit clinical effects when taken with Quinestrol
Ketoconazole (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is caused by Vemurafenib (Compound) and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol
Ketoconazole (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Anastrozole (Compound) and Anastrozole may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol