DDInter1642 DDInter757
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Fluorouracil {u} (Compound) resembles {v} (Compound) Uracil mustard
Fluorouracil {u} (Compound) treats {v} (Disease) head and neck cancer
Fluorouracil {u} (Compound) binds {v} (Gene) CYP2C8
Fluorouracil {u} (Compound) upregulates {v} (Gene) SERPINA3
Fluorouracil {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Fluorouracil {u} (Compound) downregulates {v} (Gene) PTPRO
Fluorouracil {u} (Compound) causes {v} (Side Effect) Ventricular septal defect
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Fluorouracil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Fluorouracil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Temozolomide
Fluorouracil (Compound) resembles Uracil mustard (Compound)
Fluorouracil (Compound) treats head and neck cancer (Disease)
Fluorouracil (Compound) binds CYP2C8 (Gene)
Fluorouracil (Compound) upregulates SERPINA3 (Gene)
Fluorouracil (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class)
Fluorouracil (Compound) downregulates PTPRO (Gene)
Fluorouracil (Compound) causes Ventricular septal defect (Side Effect)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide