DDInter781 DDInter1515
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955.
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is upregulated by {v} (Compound) Prednisone
Fosinopril {u} (Compound) causes {v} (Side Effect) Arthralgia
Arthralgia {u} (Side Effect) is caused by {v} (Compound) Prednisone
Fosinopril {u} (Compound) resembles {v} (Compound) Trandolapril
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Fosinopril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) regulates {v} (Gene) ZDHHC6
ZDHHC6 {u} (Gene) is downregulated by {v} (Compound) Prednisone
Fosinopril {u} (Compound) causes {v} (Side Effect) Arthralgia
Arthralgia {u} (Side Effect) is caused by {v} (Compound) Ciclesonide
Ciclesonide {u} (Compound) resembles {v} (Compound) Prednisone
Fosinopril {u} (Compound) causes {v} (Side Effect) Angiitis necrotising
Angiitis necrotising {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Fludrocortisone {u} (Compound) resembles {v} (Compound) Prednisone
Fosinopril {u} (Compound) causes {v} (Side Effect) Memory impairment
Memory impairment {u} (Side Effect) is caused by {v} (Compound) Alprazolam
Alprazolam {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prednisone
Fosinopril {u} (Compound) causes {v} (Side Effect) Erectile dysfunction
Erectile dysfunction {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prednisone
Fosinopril {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Meclofenamic acid
Meclofenamic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Fosinopril (Compound) upregulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Prednisone (Compound)
Fosinopril (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Prednisone (Compound)
Fosinopril (Compound) resembles Trandolapril (Compound) and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Fosinopril (Compound) resembles Lisinopril (Compound) and Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Fosinopril (Compound) upregulates SYNGR3 (Gene) and SYNGR3 (Gene) regulates ZDHHC6 (Gene) and ZDHHC6 (Gene) is downregulated by Prednisone (Compound)
Fosinopril (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Ciclesonide (Compound) and Ciclesonide (Compound) resembles Prednisone (Compound)
Fosinopril (Compound) causes Angiitis necrotising (Side Effect) and Angiitis necrotising (Side Effect) is caused by Fludrocortisone (Compound) and Fludrocortisone (Compound) resembles Prednisone (Compound)
Fosinopril (Compound) causes Memory impairment (Side Effect) and Memory impairment (Side Effect) is caused by Alprazolam (Compound) and Alprazolam may cause a minor interaction that can limit clinical effects when taken with Prednisone
Fosinopril (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Prednisone
Fosinopril (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Meclofenamic acid (Compound) and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Prednisone