DDInter336 DDInter248
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Bumetanide is a sulfamyl diuretic.
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Bumetanide
Celecoxib {u} (Compound) causes {v} (Side Effect) Blood uric acid increased
Blood uric acid increased {u} (Side Effect) is caused by {v} (Compound) Bumetanide
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Celecoxib {u} (Compound) causes {v} (Side Effect) Blood uric acid increased
Blood uric acid increased {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Bumetanide
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) regulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Bumetanide
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) chronic kidney failure
chronic kidney failure {u} (Disease) is palliated by {v} (Compound) Bumetanide
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Bumetanide
Celecoxib {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Bumetanide
Celecoxib {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is associated with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Bumetanide
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) is bound by Bumetanide (Compound)
Celecoxib (Compound) causes Blood uric acid increased (Side Effect) and Blood uric acid increased (Side Effect) is caused by Bumetanide (Compound)
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) is bound by Indapamide (Compound) and Indapamide (Compound) resembles Bumetanide (Compound)
Celecoxib (Compound) causes Blood uric acid increased (Side Effect) and Blood uric acid increased (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Bumetanide (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Bumetanide (Compound)
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) regulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Bumetanide (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with chronic kidney failure (Disease) and chronic kidney failure (Disease) is palliated by Bumetanide (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Bumetanide (Compound)
Celecoxib (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Fenoprofen (Compound) and Fenoprofen (Compound) resembles Bumetanide (Compound)
Celecoxib (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is associated with PTGS2 (Gene) and PTGS2 (Gene) is bound by Bumetanide (Compound)