DDInter162 DDInter748
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
Baclofen {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Flumazenil
Baclofen {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Zolpidem
Zolpidem {u} may cause a minor interaction that can limit clinical effects when taken with {v} Flumazenil
Baclofen {u} (Compound) causes {v} (Side Effect) Tongue disorder
Tongue disorder {u} (Side Effect) is caused by {v} (Compound) Clonazepam
Clonazepam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Baclofen {u} (Compound) causes {v} (Side Effect) Paranoia
Paranoia {u} (Side Effect) is caused by {v} (Compound) Clomipramine
Clomipramine {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Baclofen {u} (Compound) binds {v} (Gene) GABBR1
GABBR1 {u} (Gene) interacts with {v} (Gene) GABRG2
GABRG2 {u} (Gene) is bound by {v} (Compound) Flumazenil
Baclofen {u} (Compound) causes {v} (Side Effect) Abnormal vision
Abnormal vision {u} (Side Effect) is caused by {v} (Compound) Estazolam
Estazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Baclofen {u} (Compound) causes {v} (Side Effect) Nasal congestion
Nasal congestion {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Baclofen {u} (Compound) binds {v} (Gene) GABBR2
GABBR2 {u} (Gene) regulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Flumazenil
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Flumazenil
Baclofen {u} (Compound) binds {v} (Gene) GABBR1
GABBR1 {u} (Gene) regulates {v} (Gene) SHB
SHB {u} (Gene) is downregulated by {v} (Compound) Flumazenil
Baclofen (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Flumazenil (Compound)
Baclofen (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Zolpidem (Compound) and Zolpidem may cause a minor interaction that can limit clinical effects when taken with Flumazenil
Baclofen (Compound) causes Tongue disorder (Side Effect) and Tongue disorder (Side Effect) is caused by Clonazepam (Compound) and Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Baclofen (Compound) causes Paranoia (Side Effect) and Paranoia (Side Effect) is caused by Clomipramine (Compound) and Clomipramine may lead to a major life threatening interaction when taken with Flumazenil
Baclofen (Compound) binds GABBR1 (Gene) and GABBR1 (Gene) interacts with GABRG2 (Gene) and GABRG2 (Gene) is bound by Flumazenil (Compound)
Baclofen (Compound) causes Abnormal vision (Side Effect) and Abnormal vision (Side Effect) is caused by Estazolam (Compound) and Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Baclofen (Compound) causes Nasal congestion (Side Effect) and Nasal congestion (Side Effect) is caused by Doxepin (Compound) and Doxepin may lead to a major life threatening interaction when taken with Flumazenil
Baclofen (Compound) binds GABBR2 (Gene) and GABBR2 (Gene) regulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Flumazenil (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Flumazenil (Compound)
Baclofen (Compound) binds GABBR1 (Gene) and GABBR1 (Gene) regulates SHB (Gene) and SHB (Gene) is downregulated by Flumazenil (Compound)