DDInter1853 DDInter1758
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Telithromycin
Tretinoin {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Telithromycin
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Erythromycin
Erythromycin {u} (Compound) resembles {v} (Compound) Telithromycin
Tretinoin {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Aprepitant
Aprepitant {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telithromycin
Tretinoin {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Azithromycin
Azithromycin {u} (Compound) resembles {v} (Compound) Telithromycin
Tretinoin {u} (Compound) causes {v} (Side Effect) Back pain
Back pain {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Telithromycin
Tretinoin {u} (Compound) causes {v} (Side Effect) Coagulopathy
Coagulopathy {u} (Side Effect) is caused by {v} (Compound) Salbutamol
Salbutamol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telithromycin
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telithromycin
Tretinoin {u} (Compound) downregulates {v} (Gene) SLC35A1
SLC35A1 {u} (Gene) is upregulated by {v} (Compound) Azithromycin
Azithromycin {u} (Compound) resembles {v} (Compound) Telithromycin
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Sorafenib
Sorafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telithromycin
Tretinoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Telithromycin (Compound)
Tretinoin (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Telithromycin (Compound)
Tretinoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Erythromycin (Compound) and Erythromycin (Compound) resembles Telithromycin (Compound)
Tretinoin (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Aprepitant (Compound) and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Telithromycin
Tretinoin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Azithromycin (Compound) and Azithromycin (Compound) resembles Telithromycin (Compound)
Tretinoin (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telithromycin
Tretinoin (Compound) causes Coagulopathy (Side Effect) and Coagulopathy (Side Effect) is caused by Salbutamol (Compound) and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Telithromycin
Tretinoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Telithromycin
Tretinoin (Compound) downregulates SLC35A1 (Gene) and SLC35A1 (Gene) is upregulated by Azithromycin (Compound) and Azithromycin (Compound) resembles Telithromycin (Compound)
Tretinoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telithromycin