DDInter350 DDInter1835
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) downregulates {v} (Gene) CENPA
CENPA {u} (Gene) is downregulated by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) upregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) causes {v} (Side Effect) Mucosal inflammation
Mucosal inflammation {u} (Side Effect) is caused by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Chlorambucil {u} (Compound) treats {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) resembles {v} (Disease) cervical cancer
cervical cancer {u} (Disease) is treated by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Irinotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Chlorambucil {u} (Compound) upregulates {v} (Gene) CSTA
CSTA {u} (Gene) is regulated by {v} (Gene) KLF10
KLF10 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Topotecan
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Topotecan (Compound)
Chlorambucil (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Topotecan (Compound)
Chlorambucil (Compound) downregulates CENPA (Gene) and CENPA (Gene) is downregulated by Topotecan (Compound)
Chlorambucil (Compound) upregulates FHL2 (Gene) and FHL2 (Gene) is downregulated by Topotecan (Compound)
Chlorambucil (Compound) causes Mucosal inflammation (Side Effect) and Mucosal inflammation (Side Effect) is caused by Topotecan (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Chlorambucil (Compound) treats ovarian cancer (Disease) and ovarian cancer (Disease) resembles cervical cancer (Disease) and cervical cancer (Disease) is treated by Topotecan (Compound)
Chlorambucil (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Irinotecan (Compound) and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Chlorambucil (Compound) upregulates CSTA (Gene) and CSTA (Gene) is regulated by KLF10 (Gene) and KLF10 (Gene) is upregulated by Topotecan (Compound)
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Topotecan (Compound)