DDInter416 DDInter1061
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available. In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Clotrimazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Etonogestrel
Etonogestrel {u} (Compound) resembles {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Ethynodiol
Ethynodiol {u} (Compound) resembles {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is downregulated by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Etonogestrel
Etonogestrel {u} (Compound) resembles {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) causes {v} (Side Effect) Abdominal bloating
Abdominal bloating {u} (Side Effect) is caused by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Levonorgestrel
Clotrimazole {u} (Compound) resembles {v} (Compound) Methadone
Methadone {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is bound by {v} (Compound) Levonorgestrel
Clotrimazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levonorgestrel (Compound)
Clotrimazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Levonorgestrel (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Levonorgestrel (Compound)
Clotrimazole (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Levonorgestrel (Compound)
Clotrimazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etonogestrel (Compound) and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Clotrimazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Ethynodiol (Compound) and Ethynodiol (Compound) resembles Levonorgestrel (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Norethisterone (Compound) and Norethisterone (Compound) resembles Levonorgestrel (Compound)
Clotrimazole (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Etonogestrel (Compound) and Etonogestrel (Compound) resembles Levonorgestrel (Compound)
Clotrimazole (Compound) causes Abdominal bloating (Side Effect) and Abdominal bloating (Side Effect) is caused by Norethisterone (Compound) and Norethisterone (Compound) resembles Levonorgestrel (Compound)
Clotrimazole (Compound) resembles Methadone (Compound) and Methadone (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Levonorgestrel (Compound)