DDInter687 DDInter255
Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids. It is used to treat or manage a variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA).
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Etanercept {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Vitamin E {u} (Compound) binds {v} (Gene) GSTA2
GSTA2 {u} (Gene) is bound by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norgestimate
Norgestimate {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Ethionamide {u} (Compound) upregulates {v} (Gene) NUDT9
NUDT9 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethambutol
Ethambutol {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethionamide
Ethionamide {u} (Compound) upregulates {v} (Gene) CTNNAL1
CTNNAL1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etravirine
Etravirine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Simvastatin
Simvastatin {u} (Compound) downregulates {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Crizotinib
Crizotinib {u} (Compound) binds {v} (Gene) EPHA3
EPHA3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Etanercept {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Crizotinib
Crizotinib {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) ABL1
ABL1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Etanercept {u} may lead to a major life threatening interaction when taken with {v} Dexamethasone
Dexamethasone {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E (Compound) binds GSTA2 (Gene) and GSTA2 (Gene) is bound by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Norgestimate and Norgestimate (Compound) downregulates MYC (Gene) and MYC (Gene) is downregulated by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide (Compound) upregulates NUDT9 (Gene) and NUDT9 (Gene) is upregulated by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol and Ethambutol (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide and Ethionamide (Compound) upregulates CTNNAL1 (Gene) and CTNNAL1 (Gene) is downregulated by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin (Compound) downregulates PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib (Compound) binds EPHA3 (Gene) and EPHA3 (Gene) is upregulated by Busulfan (Compound)
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib (Compound) binds ABL1 (Gene) and Crizotinib (Compound) upregulates ABL1 (Gene) and ABL1 (Gene) is upregulated by Busulfan (Compound)
Etanercept may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)