DDInter1888 DDInter1376
An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Tryptophan {u} (Compound) resembles {v} (Compound) L-Phenylalanine
Tryptophan {u} (Compound) resembles {v} (Compound) L-Histidine
Tryptophan {u} (Compound) binds {v} (Gene) SLC16A2
Tryptophan {u} (Compound) upregulates {v} (Gene) ADGRE5
Tryptophan (Compound) resembles L-Phenylalanine (Compound)
Tryptophan (Compound) resembles L-Histidine (Compound)
Tryptophan (Compound) binds SLC16A2 (Gene)
Tryptophan (Compound) upregulates ADGRE5 (Gene)