DDInter458 DDInter1491
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCND3
CCND3 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Thalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) upregulates {v} (Gene) INTS3
INTS3 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Thalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Thalidomide
Thalidomide {u} (Compound) resembles {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) upregulates {v} (Gene) BIRC2
BIRC2 {u} (Gene) interacts with {v} (Gene) TNF
TNF {u} (Gene) is bound by {v} (Compound) Pomalidomide
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is associated with {v} (Gene) TNF
TNF {u} (Gene) is bound by {v} (Compound) Pomalidomide
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pomalidomide (Compound)
Cyclosporine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Pomalidomide (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Pomalidomide (Compound)
Cyclosporine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Pomalidomide (Compound)
Cyclosporine (Compound) downregulates CCND3 (Gene) and CCND3 (Gene) is upregulated by Thalidomide (Compound) and Thalidomide (Compound) resembles Pomalidomide (Compound)
Cyclosporine (Compound) upregulates INTS3 (Gene) and INTS3 (Gene) is upregulated by Thalidomide (Compound) and Thalidomide (Compound) resembles Pomalidomide (Compound)
Cyclosporine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Pomalidomide (Compound)
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Thalidomide (Compound) and Thalidomide (Compound) resembles Pomalidomide (Compound)
Cyclosporine (Compound) upregulates BIRC2 (Gene) and BIRC2 (Gene) interacts with TNF (Gene) and TNF (Gene) is bound by Pomalidomide (Compound)
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is associated with TNF (Gene) and TNF (Gene) is bound by Pomalidomide (Compound)