DDInter458 DDInter195
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT3
DDIT3 {u} (Gene) is downregulated by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) downregulates {v} (Gene) AURKB
AURKB {u} (Gene) is downregulated by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Angioedema
Angioedema {u} (Side Effect) is caused by {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Methylprednisolone
Methylprednisolone {u} (Compound) resembles {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Budesonide
Budesonide {u} (Compound) resembles {v} (Compound) Betamethasone
Cyclosporine {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Clobetasol propionate
Clobetasol propionate {u} (Compound) resembles {v} (Compound) Betamethasone
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Betamethasone (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Betamethasone (Compound)
Cyclosporine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Betamethasone (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Betamethasone (Compound)
Cyclosporine (Compound) upregulates DDIT3 (Gene) and DDIT3 (Gene) is downregulated by Betamethasone (Compound)
Cyclosporine (Compound) downregulates AURKB (Gene) and AURKB (Gene) is downregulated by Betamethasone (Compound)
Cyclosporine (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Betamethasone (Compound)
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Methylprednisolone (Compound) and Methylprednisolone (Compound) resembles Betamethasone (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Budesonide (Compound) and Budesonide (Compound) resembles Betamethasone (Compound)
Cyclosporine (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Clobetasol propionate (Compound) and Clobetasol propionate (Compound) resembles Betamethasone (Compound)