DDInter1834 DDInter395
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Clemastine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Clemastine
Topiramate {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Clemastine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Eletriptan
Eletriptan {u} (Compound) resembles {v} (Compound) Clemastine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Topiramate {u} (Compound) causes {v} (Side Effect) Confusional state
Confusional state {u} (Side Effect) is caused by {v} (Compound) Eletriptan
Eletriptan {u} (Compound) resembles {v} (Compound) Clemastine
Topiramate {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Azelastine
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Topiramate {u} (Compound) causes {v} (Side Effect) Photosensitivity reaction
Photosensitivity reaction {u} (Side Effect) is caused by {v} (Compound) Trospium
Trospium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Eletriptan
Eletriptan {u} (Compound) resembles {v} (Compound) Clemastine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clemastine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Clemastine (Compound)
Topiramate (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Clemastine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Eletriptan (Compound) and Eletriptan (Compound) resembles Clemastine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Topiramate (Compound) causes Confusional state (Side Effect) and Confusional state (Side Effect) is caused by Eletriptan (Compound) and Eletriptan (Compound) resembles Clemastine (Compound)
Topiramate (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Azelastine (Compound) and Azelastine (Compound) resembles Clemastine (Compound)
Topiramate (Compound) causes Photosensitivity reaction (Side Effect) and Photosensitivity reaction (Side Effect) is caused by Trospium (Compound) and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Eletriptan (Compound) and Eletriptan (Compound) resembles Clemastine (Compound)