DDInter1834 DDInter245
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tolterodine
Tolterodine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Topiramate {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Brompheniramine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Brompheniramine
Topiramate {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) TUBB6
TUBB6 {u} (Gene) is downregulated by {v} (Compound) Brompheniramine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Brompheniramine
Topiramate {u} (Compound) causes {v} (Side Effect) Nervous system disorder
Nervous system disorder {u} (Side Effect) is caused by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Brompheniramine
Topiramate {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Brompheniramine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Brompheniramine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tolterodine (Compound) and Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Topiramate (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Brompheniramine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Brompheniramine (Compound)
Topiramate (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by TUBB6 (Gene) and TUBB6 (Gene) is downregulated by Brompheniramine (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Brompheniramine (Compound)
Topiramate (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Brompheniramine (Compound)
Topiramate (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine