DDInter624 DDInter120
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Efavirenz {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Arsenic trioxide
Efavirenz {u} (Compound) downregulates {v} (Gene) PFN1
PFN1 {u} (Gene) is regulated by {v} (Gene) JUN
JUN {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) interacts with {v} (Gene) JUN
JUN {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is regulated by {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Galantamine
Galantamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Efavirenz {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) interacts with {v} (Gene) AKT1
AKT1 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) regulates {v} (Gene) AKT1
AKT1 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Efavirenz {u} (Compound) downregulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Gatifloxacin {u} may lead to a major life threatening interaction when taken with {v} Arsenic trioxide
Efavirenz (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Efavirenz (Compound) downregulates PFN1 (Gene) and PFN1 (Gene) is regulated by JUN (Gene) and JUN (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) interacts with JUN (Gene) and JUN (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is regulated by TXNRD1 (Gene) and TXNRD1 (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Galantamine (Compound) and Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Efavirenz (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) interacts with AKT1 (Gene) and AKT1 (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) regulates AKT1 (Gene) and AKT1 (Gene) is bound by Arsenic trioxide (Compound)
Efavirenz (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Gatifloxacin (Compound) and Gatifloxacin may lead to a major life threatening interaction when taken with Arsenic trioxide