DDInter1666 DDInter1226
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minoxidil
Sildenafil {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Minoxidil
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minoxidil
Sildenafil {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Dexmedetomidine
Dexmedetomidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minoxidil
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Vardenafil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitrous acid
Nitrous acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minoxidil
Sildenafil {u} (Compound) upregulates {v} (Gene) LPL
LPL {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Minoxidil
Sildenafil {u} (Compound) binds {v} (Gene) PDE5A
PDE5A {u} (Gene) is bound by {v} (Compound) Tadalafil
Tadalafil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minoxidil
Sildenafil {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Amitriptyline
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minoxidil
Sildenafil {u} (Compound) downregulates {v} (Gene) IGFBP2
IGFBP2 {u} (Gene) is associated with {v} (Disease) and {u} (Gene) is upregulated by {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Minoxidil
Sildenafil {u} (Compound) upregulates {v} (Gene) LPL
LPL {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minoxidil
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil
Sildenafil (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Minoxidil (Compound)
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil
Sildenafil (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dexmedetomidine (Compound) and Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil
Sildenafil (Compound) resembles Vardenafil (Compound) and Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid and Nitrous acid may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil
Sildenafil (Compound) upregulates LPL (Gene) and LPL (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Minoxidil (Compound)
Sildenafil (Compound) binds PDE5A (Gene) and PDE5A (Gene) is bound by Tadalafil (Compound) and Tadalafil may cause a minor interaction that can limit clinical effects when taken with Minoxidil
Sildenafil (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Amitriptyline (Compound) and Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil
Sildenafil (Compound) downregulates IGFBP2 (Gene) and IGFBP2 (Gene) is associated with hypertension (Disease) and IGFBP2 (Gene) is upregulated by hypertension (Disease) and hypertension (Disease) is treated by Minoxidil (Compound)
Sildenafil (Compound) upregulates LPL (Gene) and LPL (Gene) is upregulated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil