DDInter148 DDInter150
Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis. The other one is through the inhibition of DNA methyltransferase, impairing DNA methylation. Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA, azacytidine has been used mainly used in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), two types of cancer characterized by the presence of aberrant DNA methylation.[
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Azacitidine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Azacitidine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) upregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Azacitidine {u} (Compound) downregulates {v} (Gene) MCM3
MCM3 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Azacitidine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Azathioprine (Compound)
Azacitidine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) and Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) includes Azathioprine (Compound)
Azacitidine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Azacitidine (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Azathioprine (Compound)
Azacitidine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Azacitidine (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Azacitidine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Azacitidine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Azacitidine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by RRP1B (Gene) and RRP1B (Gene) is downregulated by Azathioprine (Compound)
Azacitidine (Compound) downregulates MCM3 (Gene) and MCM3 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)