DDInter1158 DDInter150
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Mesalazine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) causes {v} (Side Effect) Liver injury
Liver injury {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) resembles {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) resembles {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) upregulates {v} (Gene) CCL2
CCL2 {u} (Gene) is associated with {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) upregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mesalazine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mesalazine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Azathioprine (Compound)
Mesalazine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Azathioprine (Compound)
Mesalazine (Compound) causes Liver injury (Side Effect) and Liver injury (Side Effect) is caused by Azathioprine (Compound)
Mesalazine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) resembles ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Azathioprine (Compound)
Mesalazine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) resembles Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Azathioprine (Compound)
Mesalazine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Mesalazine (Compound) upregulates CCL2 (Gene) and CCL2 (Gene) is associated with systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Azathioprine (Compound)
Mesalazine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Azathioprine (Compound)
Mesalazine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) upregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Mesalazine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by RPIA (Gene) and RPIA (Gene) is downregulated by Azathioprine (Compound)