DDInter909 DDInter1627
Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy".. The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment can be tailored specifically to the unique cancer genetics of each patient. Imatinib was approved on February 1st,2001 by the FDA and November 7th, 2001 by the EMA; however, its European approval has been withdrawn in October 2023.[A263036,L49746,L49751]
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Imatinib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Imatinib {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Rufinamide
Imatinib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Imatinib {u} may lead to a major life threatening interaction when taken with {v} Phenytoin
Phenytoin {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Imatinib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) interacts with {v} (Gene) SCN5A
SCN5A {u} (Gene) is bound by {v} (Compound) Rufinamide
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Clonazepam {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Imatinib {u} may lead to a major life threatening interaction when taken with {v} Phenytoin
Phenytoin {u} (Compound) binds {v} (Gene) SCN2A
SCN2A {u} (Gene) is bound by {v} (Compound) Rufinamide
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonazepam
Clonazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clobazam
Clobazam {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Rufinamide
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clobazam
Clobazam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rufinamide
Imatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Imatinib (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Rufinamide (Compound)
Imatinib (Compound) binds ALB (Gene) and ALB (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Imatinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Imatinib (Compound) binds ALB (Gene) and ALB (Gene) interacts with SCN5A (Gene) and SCN5A (Gene) is bound by Rufinamide (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam and Clonazepam (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Imatinib may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) binds SCN2A (Gene) and SCN2A (Gene) is bound by Rufinamide (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clonazepam and Clonazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Rufinamide (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rufinamide (Compound)