DDInter388 DDInter833
Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the inhibition of serotonin reuptake, and among all the SSRIs, citalopram appears to be the most selective toward serotonin reuptake inhibition.[A261316,A14720] Specifically, it has a very minimal effect on dopamine and norepinephrine transportation and virtually no affinity for muscarinic, histaminergic, or GABAergic receptors. Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 years or older.
Glycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.
Citalopram {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tripelennamine
Tripelennamine {u} (Compound) resembles {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) resembles {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may lead to a major life threatening interaction when taken with {v} Orciprenaline
Orciprenaline {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desmopressin
Desmopressin {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may cause a minor interaction that can limit clinical effects when taken with {v} Zafirlukast
Zafirlukast {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Citalopram {u} may lead to a major life threatening interaction when taken with {v} Ticlopidine
Ticlopidine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Citalopram (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine (Compound) resembles Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Citalopram (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Citalopram (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Citalopram may lead to a major life threatening interaction when taken with Orciprenaline and Orciprenaline (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Citalopram may cause a minor interaction that can limit clinical effects when taken with Zafirlukast and Zafirlukast (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Citalopram may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)