DDInter1938 DDInter1073
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically, it binds to the 23S ribosomal RNA of the 50S subunit[A11227,A199050] and, in doing so, prevents the formation of the 70S initiation complex which is essential for bacterial reproduction. Linezolid was initially approved in 2000 and was the first member of the oxazolidinone antibiotic class. A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered generally more effective and tolerable than its predecessor.
Vincristine {u} (Compound) downregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Linezolid
Vincristine {u} (Compound) upregulates {v} (Gene) PRKAG2
PRKAG2 {u} (Gene) is upregulated by {v} (Compound) Linezolid
Vincristine {u} (Compound) downregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is downregulated by {v} (Compound) Linezolid
Vincristine {u} (Compound) causes {v} (Side Effect) Aspartate aminotransferase increased
Aspartate aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Linezolid
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Linezolid
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Linezolid
Vincristine {u} (Compound) downregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Linezolid
Vincristine {u} (Compound) downregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Linezolid
Vincristine {u} (Compound) upregulates {v} (Gene) PRKAG2
PRKAG2 {u} (Gene) regulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Linezolid
Vincristine {u} (Compound) downregulates {v} (Gene) RAP1GAP
RAP1GAP {u} (Gene) is downregulated by {v} (Compound) Triprolidine
Triprolidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Linezolid
Vincristine (Compound) downregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Linezolid (Compound)
Vincristine (Compound) upregulates PRKAG2 (Gene) and PRKAG2 (Gene) is upregulated by Linezolid (Compound)
Vincristine (Compound) downregulates RAP1GAP (Gene) and RAP1GAP (Gene) is downregulated by Linezolid (Compound)
Vincristine (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Linezolid (Compound)
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Vincristine (Compound) downregulates DDIT4 (Gene) and DDIT4 (Gene) regulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Linezolid (Compound)
Vincristine (Compound) downregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Linezolid (Compound)
Vincristine (Compound) upregulates PRKAG2 (Gene) and PRKAG2 (Gene) regulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Linezolid (Compound)
Vincristine (Compound) downregulates RAP1GAP (Gene) and RAP1GAP (Gene) is downregulated by Triprolidine (Compound) and Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Linezolid