DDInter458 DDInter1174
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) is treated by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) downregulates {v} (Gene) DHFR
DHFR {u} (Gene) is bound by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) downregulates {v} (Gene) TIMELESS
TIMELESS {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST6GALNAC2
ST6GALNAC2 {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) downregulates {v} (Gene) KIF18A
KIF18A {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) upregulates {v} (Gene) RPN1
RPN1 {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) causes {v} (Side Effect) Septicemia
Septicemia {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) treats {v} (Disease) psoriasis
psoriasis {u} (Disease) resembles {v} (Disease) psoriatic arthritis
psoriatic arthritis {u} (Disease) is treated by {v} (Compound) Methotrexate
Cyclosporine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) resembles {v} (Disease) psoriatic arthritis
psoriatic arthritis {u} (Disease) is treated by {v} (Compound) Methotrexate
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) is treated by Methotrexate (Compound)
Cyclosporine (Compound) downregulates DHFR (Gene) and DHFR (Gene) is bound by Methotrexate (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Methotrexate (Compound)
Cyclosporine (Compound) downregulates TIMELESS (Gene) and TIMELESS (Gene) is upregulated by Methotrexate (Compound)
Cyclosporine (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Methotrexate (Compound)
Cyclosporine (Compound) downregulates KIF18A (Gene) and KIF18A (Gene) is downregulated by Methotrexate (Compound)
Cyclosporine (Compound) upregulates RPN1 (Gene) and RPN1 (Gene) is downregulated by Methotrexate (Compound)
Cyclosporine (Compound) causes Septicemia (Side Effect) and Septicemia (Side Effect) is caused by Methotrexate (Compound)
Cyclosporine (Compound) treats psoriasis (Disease) and psoriasis (Disease) resembles psoriatic arthritis (Disease) and psoriatic arthritis (Disease) is treated by Methotrexate (Compound)
Cyclosporine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) resembles psoriatic arthritis (Disease) and psoriatic arthritis (Disease) is treated by Methotrexate (Compound)