DDInter1340 DDInter1442
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Omeprazole {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Omeprazole {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Omeprazole {u} (Compound) resembles {v} (Compound) Esomeprazole
Esomeprazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Omeprazole {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) is bound by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Omeprazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Omeprazole {u} (Compound) binds {v} (Gene) CYP1B1
CYP1B1 {u} (Gene) is bound by {v} (Compound) Lansoprazole
Lansoprazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Omeprazole {u} (Compound) causes {v} (Side Effect) Irritability
Irritability {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Methsuximide {u} (Compound) resembles {v} (Compound) Phenobarbital
Omeprazole {u} (Compound) causes {v} (Side Effect) Renal failure
Renal failure {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Omeprazole {u} (Compound) resembles {v} (Compound) Esomeprazole
Esomeprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Omeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) resembles {v} (Compound) Lansoprazole
Lansoprazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Omeprazole (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Phenobarbital (Compound)
Omeprazole (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Phenobarbital (Compound)
Omeprazole (Compound) resembles Esomeprazole (Compound) and Es
Omeprazole (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) is bound by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Omeprazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Primidone (Compound) and Primidone (Compound) resembles Phenobarbital (Compound)
Omeprazole (Compound) binds CYP1B1 (Gene) and CYP1B1 (Gene) is bound by Lansoprazole (Compound) and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Omeprazole (Compound) causes Irritability (Side Effect) and Irritability (Side Effect) is caused by Methsuximide (Compound) and Methsuximide (Compound) resembles Phenobarbital (Compound)
Omeprazole (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Phenobarbital (Compound)
Omeprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound)
Omeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) resembles Lansoprazole (Compound) and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Phenobarbital