DDInter1042 DDInter1464
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.
Picosulfuric acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Picosulfuric acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methylcellulose
Picosulfuric acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimipramine
Picosulfuric acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Picosulfuric acid {u} may lead to a major life threatening interaction when taken with {v} Sotalol
Picosulfuric acid may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Picosulfuric acid may cause a minor interaction that can limit clinical effects when taken with Methylcellulose
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Picosulfuric acid may lead to a major life threatening interaction when taken with Sotalol