DDInter1843 DDInter1123
Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chiesi USA Inc.
Trandolapril {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Trandolapril {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Calcium glucoheptonate
Calcium glucoheptonate {u} (Compound) resembles {v} (Compound) Mannitol
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Trandolapril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Dronabinol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mannitol
Trandolapril {u} (Compound) resembles {v} (Compound) Lisinopril
Lisinopril {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dronabinol
Dronabinol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Trandolapril {u} may lead to a major life threatening interaction when taken with {v} Potassium Iodide
Potassium Iodide {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Mannitol
Trandolapril {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Nateglinide {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Mannitol
Trandolapril (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Trandolapril (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Calcium glucoheptonate (Compound) and Calcium glucoheptonate (Compound) resembles Mannitol (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Trandolapril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mannitol (Compound)
Trandolapril (Compound) resembles Lisinopril (Compound) and Lisinopril (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Trandolapril may lead to a major life threatening interaction when taken with Potassium Iodide and Potassium Iodide (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Mannitol (Compound)
Trandolapril (Compound) resembles Nateglinide (Compound) and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Mannitol (Compound)