DDInter1609 DDInter1752
Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Drug-resistant bacteria, such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved [linezolid] and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and is generally more effective and more tolerable than [linezolid].[L11232, A199086, A199050] Tedizolid was approved by the FDA on June 20, 2014, for sale by Cubist Pharmaceuticals as tedizolid phosphate (SIVEXTRO®). This product is currently available as both an oral tablet and as a powder for intravenous injection.
Rivaroxaban {u} (Compound) resembles {v} (Compound) Linezolid
Rivaroxaban {u} (Compound) binds {v} (Gene) ABCB1
Rivaroxaban {u} (Compound) upregulates {v} (Gene) CDK6
Rivaroxaban {u} (Compound) downregulates {v} (Gene) GJA1
Rivaroxaban {u} (Compound) causes {v} (Side Effect) Pruritus
Rivaroxaban {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chamomile
Rivaroxaban {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Rivaroxaban {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calaspargase pegol
Rivaroxaban {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Rivaroxaban {u} may lead to a major life threatening interaction when taken with {v} Regorafenib
Rivaroxaban (Compound) resembles Linezolid (Compound)
Rivaroxaban (Compound) binds ABCB1 (Gene)
Rivaroxaban (Compound) upregulates CDK6 (Gene)
Rivaroxaban (Compound) downregulates GJA1 (Gene)
Rivaroxaban (Compound) causes Pruritus (Side Effect)
Rivaroxaban may cause a minor interaction that can limit clinical effects when taken with Chamomile
Rivaroxaban may cause a minor interaction that can limit clinical effects when taken with Modafinil
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Rivaroxaban may lead to a major life threatening interaction when taken with Regorafenib