DDInter1639 DDInter1174
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is associated with {v} (Disease) stomach cancer
stomach cancer {u} (Disease) is treated by {v} (Compound) Methotrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) MMP1
MMP1 {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Sapropterin {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) is regulated by {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Methotrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Pemetrexed
Pemetrexed {u} (Compound) resembles {v} (Compound) Methotrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Urine output increased
Urine output increased {u} (Side Effect) is caused by {v} (Compound) Lamotrigine
Lamotrigine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methotrexate
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methotrexate
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) interacts with {v} (Gene) NOSIP
NOSIP {u} (Gene) is downregulated by {v} (Compound) Methotrexate
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Methotrexate (Compound)
Sapropterin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Methotrexate (Compound)
Sapropterin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Methotrexate (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is associated with stomach cancer (Disease) and stomach cancer (Disease) is treated by Methotrexate (Compound)
Sapropterin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates MMP1 (Gene) and MMP1 (Gene) is upregulated by Methotrexate (Compound)
Sapropterin (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) is regulated by ABCC1 (Gene) and ABCC1 (Gene) is bound by Methotrexate (Compound)
Sapropterin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Pemetrexed (Compound) and Pemetrexed (Compound) resembles Methotrexate (Compound)
Sapropterin (Compound) causes Urine output increased (Side Effect) and Urine output increased (Side Effect) is caused by Lamotrigine (Compound) and Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) interacts with NOSIP (Gene) and NOSIP (Gene) is downregulated by Methotrexate (Compound)