DDInter419 DDInter255
Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine receptors results in fewer extrapyramidal side effects, especially tardive dyskinesia. However, its promiscuity toward the muscarinic and adrenergic receptors can result in other side effects, notably gastrointestinal hypomotility and orthostatic hypotension. [L905,A215552]. Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis.[A256713,A256718] However, continued evidence of its effectiveness led to clozapine's eventual reintroduction, although
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Clozapine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Clozapine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) upregulates {v} (Gene) NNT
NNT {u} (Gene) is downregulated by {v} (Compound) Busulfan
Clozapine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) SNCA
SNCA {u} (Gene) is upregulated by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) downregulates {v} (Gene) PSMD2
PSMD2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Oxazepam
Oxazepam {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Clozapine {u} (Compound) resembles {v} (Compound) Prochlorperazine
Prochlorperazine {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Busulfan
Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Clozapine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Busulfan (Compound)
Clozapine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine (Compound) upregulates NNT (Gene) and NNT (Gene) is downregulated by Busulfan (Compound)
Clozapine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by SNCA (Gene) and SNCA (Gene) is upregulated by Busulfan (Compound)
Clozapine (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Clozapine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine (Compound) downregulates PSMD2 (Gene) and PSMD2 (Gene) is upregulated by Busulfan (Compound)
Clozapine (Compound) resembles Prochlorperazine (Compound) and Prochlorperazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Clozapine (Compound) resembles Oxazepam (Compound) and Oxazepam (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Busulfan (Compound)
Clozapine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Busulfan (Compound)
Clozapine (Compound) resembles Prochlorperazine (Compound) and Prochlorperazine (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Busulfan (Compound)