DDInter1640 DDInter1016
Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a relatively benign adverse effect profile as compared to other antiretroviral therapies. While its efficacy was initially limited by exceptionally poor oral bioavailability (approximately 4%), its current indications require the co-administration of ritonavir - a potent enzyme inhibitor - that increases the bioavailability and subsequent serum concentrations of saquinavir, thus dramatically improving antiviral activity.[A214382,L3450,L14351]
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Saquinavir {u} (Compound) resembles {v} (Compound) Lopinavir
Saquinavir {u} (Compound) resembles {v} (Compound) Nelfinavir
Saquinavir {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
Saquinavir {u} (Compound) binds {v} (Gene) SLCO1B1
Saquinavir {u} (Compound) upregulates {v} (Gene) UBQLN2
Saquinavir {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A Inhibitors
Saquinavir {u} (Compound) downregulates {v} (Gene) COG2
Saquinavir {u} (Compound) causes {v} (Side Effect) Renal failure acute
Saquinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Saquinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin human
Saquinavir (Compound) resembles Lopinavir (Compound)
Saquinavir (Compound) resembles Nelfinavir (Compound)
Saquinavir (Compound) treats acquired immunodeficiency syndrome (Disease)
Saquinavir (Compound) binds SLCO1B1 (Gene)
Saquinavir (Compound) upregulates UBQLN2 (Gene)
Saquinavir (Compound) is included by Cytochrome P450 3A Inhibitors (Pharmacologic Class)
Saquinavir (Compound) downregulates COG2 (Gene)
Saquinavir (Compound) causes Renal failure acute (Side Effect)
Saquinavir may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Insulin human