DDInter1622 DDInter604
Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as drospirenone exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be considered when assessing potential risks of hormonal contraceptive use.
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} (Compound) causes {v} (Side Effect) Breast disorder
Breast disorder {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) resembles {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} (Compound) causes {v} (Side Effect) Breast disorder
Breast disorder {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Formestane
Formestane {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} (Compound) causes {v} (Side Effect) Breast disorder
Breast disorder {u} (Side Effect) is caused by {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norethisterone and Norethisterone (Compound) resembles Drospirenone (Compound)
Rosuvastatin (Compound) causes Breast disorder (Side Effect) and Breast disorder (Side Effect) is caused by Drospirenone (Compound)
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norethisterone and Norethisterone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesterone acetate and Medroxyprogesterone acetate (Compound) resembles Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Rosuvastatin (Compound) causes Breast disorder (Side Effect) and Breast disorder (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Rosuvastatin (Compound) downregulates MYC (Gene) and MYC (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Norethisterone and Norethisterone (Compound) resembles Formestane (Compound) and Formestane (Compound) resembles Drospirenone (Compound)
Rosuvastatin (Compound) causes Breast disorder (Side Effect) and Breast disorder (Side Effect) is caused by Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Drospirenone (Compound)
Rosuvastatin (Compound) downregulates MYC (Gene) and MYC (Gene) is downregulated by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Rosuvastatin (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)