DDInter991 DDInter1435
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. The first isotretinoin-containing product was FDA approved on 7 May 1982.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Isotretinoin {u} (Compound) treats {v} (Disease) peripheral nervous system neoplasm
Isotretinoin {u} (Compound) binds {v} (Gene) RXRG
Isotretinoin {u} (Compound) upregulates {v} (Gene) CES1
Isotretinoin {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Isotretinoin {u} (Compound) downregulates {v} (Gene) CCDC86
Isotretinoin {u} (Compound) causes {v} (Side Effect) Anger
Isotretinoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Isotretinoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vemurafenib
Isotretinoin (Compound) resembles Tretinoin (Compound)
Isotretinoin may lead to a major life threatening interaction when taken with Acitretin
Isotretinoin (Compound) treats peripheral nervous system neoplasm (Disease)
Isotretinoin (Compound) binds RXRG (Gene)
Isotretinoin (Compound) upregulates CES1 (Gene)
Isotretinoin (Compound) is included by Retinoids (Pharmacologic Class)
Isotretinoin (Compound) downregulates CCDC86 (Gene)
Isotretinoin (Compound) causes Anger (Side Effect)
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin
Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib