DDInter1841 DDInter1180
Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and norepinpehrine which activate descending pain inhibitory pathways. Tramadol's effects on serotonin and norepinephrine mimic the effects of other SNRI antidepressants such as [dul
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Tramadol {u} (Compound) resembles {v} (Compound) Venlafaxine
Tramadol {u} (Compound) resembles {v} (Compound) Dextromethorphan
Tramadol {u} (Compound) binds {v} (Gene) SLC6A4
Tramadol {u} (Compound) upregulates {v} (Gene) DNMT1
Tramadol {u} (Compound) palliates {v} (Disease) restless legs syndrome
Tramadol {u} (Compound) is included by {v} (Pharmacologic Class) Full Opioid Agonists
Tramadol {u} (Compound) downregulates {v} (Gene) POLR2I
Tramadol {u} (Compound) causes {v} (Side Effect) Asthma
Tramadol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Tramadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isoprenaline
Tramadol (Compound) resembles Venlafaxine (Compound)
Tramadol (Compound) resembles Dextromethorphan (Compound)
Tramadol (Compound) binds SLC6A4 (Gene)
Tramadol (Compound) upregulates DNMT1 (Gene)
Tramadol (Compound) palliates restless legs syndrome (Disease)
Tramadol (Compound) is included by Full Opioid Agonists (Pharmacologic Class)
Tramadol (Compound) downregulates POLR2I (Gene)
Tramadol (Compound) causes Asthma (Side Effect)
Tramadol may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline