DDInter1158 DDInter1420
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Mesalazine {u} (Compound) upregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Pentamidine
Mesalazine {u} (Compound) downregulates {v} (Gene) KIF20A
KIF20A {u} (Gene) is downregulated by {v} (Compound) Pentamidine
Mesalazine {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Pentamidine
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentamidine
Mesalazine {u} (Compound) upregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) regulates {v} (Gene) CDK7
CDK7 {u} (Gene) is upregulated by {v} (Compound) Pentamidine
Mesalazine {u} (Compound) downregulates {v} (Gene) KIF20A
KIF20A {u} (Gene) is regulated by {v} (Gene) RELB
RELB {u} (Gene) is upregulated by {v} (Compound) Pentamidine
Mesalazine {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Lomefloxacin
Lomefloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentamidine
Mesalazine {u} (Compound) causes {v} (Side Effect) Nephritis
Nephritis {u} (Side Effect) is caused by {v} (Compound) Azithromycin
Azithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentamidine
Mesalazine {u} (Compound) causes {v} (Side Effect) Renal impairment
Renal impairment {u} (Side Effect) is caused by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentamidine
Mesalazine {u} (Compound) resembles {v} (Compound) Carbidopa
Carbidopa {u} (Compound) resembles {v} (Compound) Isoprenaline
Isoprenaline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentamidine
Mesalazine (Compound) upregulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Pentamidine (Compound)
Mesalazine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Pentamidine (Compound)
Mesalazine (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Pentamidine (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine
Mesalazine (Compound) upregulates KIAA0753 (Gene) and KIAA0753 (Gene) regulates CDK7 (Gene) and CDK7 (Gene) is upregulated by Pentamidine (Compound)
Mesalazine (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is regulated by RELB (Gene) and RELB (Gene) is upregulated by Pentamidine (Compound)
Mesalazine (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine
Mesalazine (Compound) causes Nephritis (Side Effect) and Nephritis (Side Effect) is caused by Azithromycin (Compound) and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine
Mesalazine (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pentamidine
Mesalazine (Compound) resembles Carbidopa (Compound) and Carbidopa (Compound) resembles Isoprenaline (Compound) and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine