DDInter1470 DDInter1676
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Pimozide {u} (Compound) resembles {v} (Compound) Fexofenadine
Pimozide {u} (Compound) resembles {v} (Compound) Ezetimibe
Pimozide {u} may lead to a major life threatening interaction when taken with {v} Astemizole
Pimozide {u} (Compound) binds {v} (Gene) CALM3
Pimozide {u} (Compound) upregulates {v} (Gene) GNPDA1
Pimozide {u} (Compound) palliates {v} (Disease) Gilles de la Tourette syndrome
Pimozide {u} (Compound) downregulates {v} (Gene) TMEM109
Pimozide {u} (Compound) causes {v} (Side Effect) Hypertension
Pimozide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Pimozide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Pimozide (Compound) resembles Fexofenadine (Compound)
Pimozide (Compound) resembles Ezetimibe (Compound)
Pimozide may lead to a major life threatening interaction when taken with Astemizole
Pimozide (Compound) binds CALM3 (Gene)
Pimozide (Compound) upregulates GNPDA1 (Gene)
Pimozide (Compound) palliates Gilles de la Tourette syndrome (Disease)
Pimozide (Compound) downregulates TMEM109 (Gene)
Pimozide (Compound) causes Hypertension (Side Effect)
Pimozide may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Pimozide may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine