DDInter1956 DDInter299
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Zalcitabine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Carfilzomib
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Zalcitabine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Carfilzomib
Zalcitabine {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Cabazitaxel
Cabazitaxel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Zalcitabine {u} (Compound) causes {v} (Side Effect) Hypercalcaemia
Hypercalcaemia {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Ponatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Zalcitabine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Carfilzomib
Zalcitabine {u} (Compound) resembles {v} (Compound) Didanosine
Didanosine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Carfilzomib
Zalcitabine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Zalcitabine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Bedaquiline
Bedaquiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Zalcitabine {u} (Compound) causes {v} (Side Effect) Musculoskeletal chest pain
Musculoskeletal chest pain {u} (Side Effect) is caused by {v} (Compound) Testosterone
Testosterone {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Zalcitabine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Zalcitabine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ritonavir (Compound) and Ritonavir (Compound) resembles Carfilzomib (Compound)
Zalcitabine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Cabazitaxel (Compound) and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Zalcitabine (Compound) causes Hypercalcaemia (Side Effect) and Hypercalcaemia (Side Effect) is caused by Ponatinib (Compound) and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Zalcitabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ritonavir (Compound) and Ritonavir (Compound) resembles Carfilzomib (Compound)
Zalcitabine (Compound) resembles Didanosine (Compound) and Didanosine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Zalcitabine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Zalcitabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound) and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Zalcitabine (Compound) causes Musculoskeletal chest pain (Side Effect) and Musculoskeletal chest pain (Side Effect) is caused by Testosterone (Compound) and Testosterone may lead to a major life threatening interaction when taken with Carfilzomib