DDInter98 DDInter1055
Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Anisindione {u} (Compound) resembles {v} (Compound) Diltiazem
Diltiazem {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Anisindione {u} (Compound) resembles {v} (Compound) Menadione
Menadione {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acarbose
Acarbose {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Anisindione {u} (Compound) resembles {v} (Compound) Menadione
Menadione {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Anisindione {u} (Compound) resembles {v} (Compound) Diltiazem
Diltiazem {u} (Compound) causes {v} (Side Effect) Erythema
Erythema {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Simvastatin
Simvastatin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acarbose
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Anisindione {u} (Compound) resembles {v} (Compound) Menadione
Menadione {u} (Compound) upregulates {v} (Gene) PLEKHM1
PLEKHM1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bicalutamide
Bicalutamide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Anisindione {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Apalutamide
Apalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norfloxacin
Norfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Anisindione (Compound) resembles Diltiazem (Compound) and Diltiazem (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Anisindione (Compound) resembles Menadione (Compound) and Menadione (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)
Anisindione (Compound) resembles Menadione (Compound) and Menadione (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)
Anisindione (Compound) resembles Diltiazem (Compound) and Diltiazem (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Levofloxacin (Compound)
Anisindione may cause a minor interaction that can limit clinical effects when taken with Simvastatin and Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Levofloxacin (Compound)
Anisindione (Compound) resembles Menadione (Compound) and Menadione (Compound) upregulates PLEKHM1 (Gene) and PLEKHM1 (Gene) is downregulated by Levofloxacin (Compound)
Anisindione may cause a minor interaction that can limit clinical effects when taken with Bicalutamide and Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles Levofloxacin (Compound)