DDInter1335 DDInter1763
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is bound by {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) MBTPS1
MBTPS1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) upregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) TFDP1
TFDP1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) upregulates {v} (Gene) RPP38
RPP38 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) FKBP1A
FKBP1A {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) MBTPS1
MBTPS1 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate {u} (Compound) downregulates {v} (Gene) LRP10
LRP10 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) downregulates FKBP1A (Gene) and FKBP1A (Gene) is bound by Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) downregulates MBTPS1 (Gene) and MBTPS1 (Gene) is upregulated by Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) upregulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) downregulates TFDP1 (Gene) and TFDP1 (Gene) is downregulated by Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) upregulates RPP38 (Gene) and RPP38 (Gene) is downregulated by Temsirolimus (Compound)
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) downregulates FKBP1A (Gene) and FKBP1A (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) downregulates MBTPS1 (Gene) and MBTPS1 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Omacetaxine mepesuccinate (Compound) downregulates LRP10 (Gene) and LRP10 (Gene) is downregulated by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)