DDInter458 DDInter842
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is bound by {v} (Compound) Fludarabine
Fludarabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Fludarabine
Fludarabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Topotecan
Topotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Bleomycin
Bleomycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Erlotinib
Erlotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Nitisinone
Nitisinone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Digestion impaired
Digestion impaired {u} (Side Effect) is caused by {v} (Compound) Glipizide
Glipizide {u} may lead to a major life threatening interaction when taken with {v} Grepafloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Anagrelide
Anagrelide {u} may lead to a major life threatening interaction when taken with {v} Grepafloxacin
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is bound by Fludarabine (Compound) and Fludarabine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Cyclosporine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Fludarabine (Compound) and Fludarabine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by Topotecan (Compound) and Topotecan may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin
Cyclosporine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Bleomycin (Compound) and Bleomycin may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Cyclosporine (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by Dasatinib (Compound) and Dasatinib may lead to a major life threatening interaction when taken with Grepafloxacin
Cyclosporine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Erlotinib (Compound) and Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin
Cyclosporine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Nitisinone (Compound) and Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Grepafloxacin
Cyclosporine (Compound) causes Digestion impaired (Side Effect) and Digestion impaired (Side Effect) is caused by Glipizide (Compound) and Glipizide may lead to a major life threatening interaction when taken with Grepafloxacin
Cyclosporine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Anagrelide (Compound) and Anagrelide may lead to a major life threatening interaction when taken with Grepafloxacin