DDInter150 DDInter1198
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine.
Azathioprine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Tubocurarine
Tubocurarine {u} (Compound) resembles {v} (Compound) Metocurine
Azathioprine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metocurine
Azathioprine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metocurine
Azathioprine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metocurine
Azathioprine {u} (Compound) causes {v} (Side Effect) Neoplasm
Neoplasm {u} (Side Effect) is caused by {v} (Compound) Fludrocortisone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metocurine
Azathioprine {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Gentamicin
Gentamicin {u} may lead to a major life threatening interaction when taken with {v} Metocurine
Azathioprine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metocurine
Azathioprine {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is palliated by {v} (Compound) Lidocaine
Lidocaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metocurine
Azathioprine {u} (Compound) downregulates {v} (Gene) RRP1B
RRP1B {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metocurine
Azathioprine {u} (Compound) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metocurine
Azathioprine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Tubocurarine (Compound) and Tubocurarine (Compound) resembles Metocurine (Compound)
Azathioprine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Metocurine
Azathioprine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Metocurine
Azathioprine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Metocurine
Azathioprine (Compound) causes Neoplasm (Side Effect) and Neoplasm (Side Effect) is caused by Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Metocurine
Azathioprine (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Gentamicin (Compound) and Gentamicin may lead to a major life threatening interaction when taken with Metocurine
Azathioprine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Metocurine
Azathioprine (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is palliated by Lidocaine (Compound) and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Metocurine
Azathioprine (Compound) downregulates RRP1B (Gene) and RRP1B (Gene) is upregulated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Metocurine
Azathioprine (Compound) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Metocurine