DDInter1158 DDInter1156
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Mesalazine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mesalazine {u} (Compound) causes {v} (Side Effect) Candida infection
Candida infection {u} (Side Effect) is caused by {v} (Compound) Mercaptopurine
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Mesalazine {u} (Compound) treats {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) resembles {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mesalazine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) resembles {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mesalazine {u} (Compound) causes {v} (Side Effect) Candida infection
Candida infection {u} (Side Effect) is caused by {v} (Compound) Trovafloxacin
Trovafloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Mesalazine {u} (Compound) causes {v} (Side Effect) Oral candidiasis
Oral candidiasis {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mercaptopurine
Mesalazine {u} (Compound) causes {v} (Side Effect) Drug fever
Drug fever {u} (Side Effect) is caused by {v} (Compound) Trimethoprim
Trimethoprim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Mesalazine {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is associated with {v} (Disease) Crohn's disease
Crohn's disease {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mesalazine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)
Mesalazine (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Mercaptopurine (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Mesalazine (Compound) treats Crohn's disease (Disease) and Crohn's disease (Disease) resembles ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Mercaptopurine (Compound)
Mesalazine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) resembles Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)
Mesalazine (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Trovafloxacin (Compound) and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Mesalazine (Compound) causes Oral candidiasis (Side Effect) and Oral candidiasis (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Mesalazine (Compound) causes Drug fever (Side Effect) and Drug fever (Side Effect) is caused by Trimethoprim (Compound) and Trimethoprim may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine
Mesalazine (Compound) binds MPO (Gene) and MPO (Gene) is associated with Crohn's disease (Disease) and Crohn's disease (Disease) is treated by Mercaptopurine (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Mercaptopurine (Compound)