DDInter48 DDInter1744
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout. It was initially approved by the FDA in 1966 and is now formulated by several manufacturers.
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole]. Tamoxifen was granted FDA approval on 30 December 1977.
Allopurinol {u} (Compound) causes {v} (Side Effect) Blood creatinine increased
Blood creatinine increased {u} (Side Effect) is caused by {v} (Compound) Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Blood creatinine increased
Blood creatinine increased {u} (Side Effect) is caused by {v} (Compound) Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Clomifene
Clomifene {u} (Compound) resembles {v} (Compound) Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Naftifine
Naftifine {u} (Compound) resembles {v} (Compound) Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Hepatic failure
Hepatic failure {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Hepatotoxicity
Hepatotoxicity {u} (Side Effect) is caused by {v} (Compound) Maraviroc
Maraviroc {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Allopurinol {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Colchicine
Colchicine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Allopurinol {u} (Compound) causes {v} (Side Effect) Paralysis
Paralysis {u} (Side Effect) is caused by {v} (Compound) Mirtazapine
Mirtazapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Allopurinol (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Tamoxifen (Compound)
Allopurinol (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate may cause a minor interaction that can limit clinical effects when taken with Tamoxifen
Allopurinol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Dextropropoxyphene (Compound) and Dextropropoxyphene may lead to a major life threatening interaction when taken with Tamoxifen
Allopurinol (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Clomifene (Compound) and Clomifene (Compound) resembles Tamoxifen (Compound)
Allopurinol (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Naftifine (Compound) and Naftifine (Compound) resembles Tamoxifen (Compound)
Allopurinol (Compound) causes Hepatic failure (Side Effect) and Hepatic failure (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tamoxifen
Allopurinol (Compound) causes Hepatotoxicity (Side Effect) and Hepatotoxicity (Side Effect) is caused by Maraviroc (Compound) and Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen
Allopurinol (Compound) treats gout (Disease) and gout (Disease) is treated by Colchicine (Compound) and Colchicine may lead to a major life threatening interaction when taken with Tamoxifen
Allopurinol (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Diphenhydramine (Compound) and Diphenhydramine may lead to a major life threatening interaction when taken with Tamoxifen
Allopurinol (Compound) causes Paralysis (Side Effect) and Paralysis (Side Effect) is caused by Mirtazapine (Compound) and Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen