DDInter336 DDInter1843
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Celecoxib {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Trandolapril
Celecoxib {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Perindopril
Perindopril {u} (Compound) resembles {v} (Compound) Trandolapril
Celecoxib {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Methylprednisolone
Methylprednisolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Bronchitis
Bronchitis {u} (Side Effect) is caused by {v} (Compound) Trandolapril
Celecoxib {u} (Compound) causes {v} (Side Effect) Ileus
Ileus {u} (Side Effect) is caused by {v} (Compound) Morphine
Morphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Celecoxib {u} (Compound) binds {v} (Gene) CA12
CA12 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Trandolapril
Celecoxib {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Repaglinide
Repaglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trandolapril
Celecoxib {u} (Compound) causes {v} (Side Effect) Creatinine increased
Creatinine increased {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trandolapril
Celecoxib {u} (Compound) binds {v} (Gene) MAPK14
MAPK14 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Trandolapril
Celecoxib {u} (Compound) causes {v} (Side Effect) Ileus
Ileus {u} (Side Effect) is caused by {v} (Compound) Potassium chloride
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Trandolapril
Celecoxib (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Trandolapril (Compound)
Celecoxib (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Perindopril (Compound) and Perindopril (Compound) resembles Trandolapril (Compound)
Celecoxib (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Trandolapril (Compound)
Celecoxib (Compound) causes Ileus (Side Effect) and Ileus (Side Effect) is caused by Morphine (Compound) and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril
Celecoxib (Compound) binds CA12 (Gene) and CA12 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Trandolapril (Compound)
Celecoxib (Compound) binds ALB (Gene) and ALB (Gene) is bound by Repaglinide (Compound) and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril
Celecoxib (Compound) causes Creatinine increased (Side Effect) and Creatinine increased (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Trandolapril
Celecoxib (Compound) binds MAPK14 (Gene) and MAPK14 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Trandolapril (Compound)
Celecoxib (Compound) causes Ileus (Side Effect) and Ileus (Side Effect) is caused by Potassium chloride (Compound) and Potassium chloride may lead to a major life threatening interaction when taken with Trandolapril