DDInter1537 DDInter1376
Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Propiomazine {u} (Compound) resembles {v} (Compound) Promazine
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Propiomazine {u} (Compound) resembles {v} (Compound) Cyamemazine
Propiomazine {u} (Compound) binds {v} (Gene) HTR2C
Propiomazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Propiomazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Propiomazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glargine
Propiomazine {u} may lead to a major life threatening interaction when taken with {v} Bupropion
Propiomazine {u} may lead to a major life threatening interaction when taken with {v} Morphine
Propiomazine (Compound) resembles Promazine (Compound)
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Propiomazine (Compound) resembles Cyamemazine (Compound)
Propiomazine (Compound) binds HTR2C (Gene)
Propiomazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Propiomazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine
Propiomazine may lead to a major life threatening interaction when taken with Bupropion
Propiomazine may lead to a major life threatening interaction when taken with Morphine