DDInter991 DDInter1840
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. The first isotretinoin-containing product was FDA approved on 7 May 1982.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Isotretinoin {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) upregulates {v} (Gene) CBLB
CBLB {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) downregulates {v} (Gene) BAG3
BAG3 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) binds {v} (Gene) RARG
RARG {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) downregulates {v} (Gene) AKT1
AKT1 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) downregulates {v} (Gene) ANXA2
ANXA2 {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) upregulates {v} (Gene) PLSCR1
PLSCR1 {u} (Gene) is regulated by {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) upregulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Isotretinoin (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Trabectedin (Compound)
Isotretinoin (Compound) upregulates CBLB (Gene) and CBLB (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) downregulates BAG3 (Gene) and BAG3 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) binds RARG (Gene) and RARG (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) downregulates AKT1 (Gene) and AKT1 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) downregulates ANXA2 (Gene) and ANXA2 (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) upregulates PLSCR1 (Gene) and PLSCR1 (Gene) is regulated by SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) upregulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Trabectedin (Compound)