DDInter1420 DDInter1662
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Pentamidine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sertraline
Pentamidine {u} (Compound) downregulates {v} (Gene) NSDHL
NSDHL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Pentamidine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Pentamidine {u} (Compound) upregulates {v} (Gene) IGFBP3
IGFBP3 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Pentamidine {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sertraline
Pentamidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Pentamidine {u} (Compound) downregulates {v} (Gene) NSDHL
NSDHL {u} (Gene) is upregulated by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Pentamidine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is regulated by {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Sertraline
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sertraline (Compound)
Pentamidine (Compound) downregulates NSDHL (Gene) and NSDHL (Gene) is upregulated by Sertraline (Compound)
Pentamidine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Sertraline (Compound)
Pentamidine (Compound) upregulates IGFBP3 (Gene) and IGFBP3 (Gene) is downregulated by Sertraline (Compound)
Pentamidine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sertraline (Compound)
Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Pentamidine (Compound) downregulates NSDHL (Gene) and NSDHL (Gene) is upregulated by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Pentamidine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is regulated by ALDOC (Gene) and ALDOC (Gene) is upregulated by Sertraline (Compound)