DDInter458 DDInter1400
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1B1
SLCO1B1 {u} (Gene) is bound by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) downregulates {v} (Gene) PLK4
PLK4 {u} (Gene) is bound by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) downregulates {v} (Gene) SDHB
SDHB {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 3A4 Inhibitors
Cytochrome P450 3A4 Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) upregulates {v} (Gene) FUT1
FUT1 {u} (Gene) is downregulated by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) downregulates {v} (Gene) HACD3
HACD3 {u} (Gene) is downregulated by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) causes {v} (Side Effect) Stomatitis
Stomatitis {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1B1
SLCO1B1 {u} (Gene) is bound by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pazopanib
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pazopanib
Cyclosporine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Pazopanib (Compound)
Cyclosporine (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) is bound by Pazopanib (Compound)
Cyclosporine (Compound) downregulates SDHB (Gene) and SDHB (Gene) is upregulated by Pazopanib (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Pazopanib (Compound)
Cyclosporine (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Pazopanib (Compound)
Cyclosporine (Compound) upregulates FUT1 (Gene) and FUT1 (Gene) is downregulated by Pazopanib (Compound)
Cyclosporine (Compound) downregulates HACD3 (Gene) and HACD3 (Gene) is downregulated by Pazopanib (Compound)
Cyclosporine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Pazopanib (Compound)
Cyclosporine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Rosuvastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib