DDInter1042 DDInter406
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin and bodily fluids. Although it carries _in vitro_ activity against other mycobacterium, such as _Mycobacterium tuberculosis_, it is generally considered an ineffective treatment in comparison to classic tuberculosis treatments such as [rifampicin] and [isoniazid].
Clofazimine {u} (Compound) binds {v} (Gene) ABCB1
Clofazimine {u} (Compound) upregulates {v} (Gene) HERPUD1
Clofazimine {u} (Compound) downregulates {v} (Gene) TUBB6
Clofazimine {u} (Compound) causes {v} (Side Effect) Dermatitis
Clofazimine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Clofazimine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pazopanib
Clofazimine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Daunorubicin
Clofazimine {u} may lead to a major life threatening interaction when taken with {v} Toremifene
Clofazimine {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Clofazimine (Compound) binds ABCB1 (Gene)
Clofazimine (Compound) upregulates HERPUD1 (Gene)
Clofazimine (Compound) downregulates TUBB6 (Gene)
Clofazimine (Compound) causes Dermatitis (Side Effect)
Clofazimine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin
Clofazimine may lead to a major life threatening interaction when taken with Toremifene
Clofazimine may lead to a major life threatening interaction when taken with Crizotinib