DDInter336 DDInter1325
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Celecoxib {u} (Compound) upregulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Ofloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Celecoxib {u} (Compound) upregulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Bullous eruption
Bullous eruption {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Ofloxacin
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Vemurafenib
Vemurafenib {u} may lead to a major life threatening interaction when taken with {v} Ofloxacin
Celecoxib {u} (Compound) upregulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is regulated by {v} (Gene) RB1
RB1 {u} (Gene) is downregulated by {v} (Compound) Ofloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Haemorrhoids
Haemorrhoids {u} (Side Effect) is caused by {v} (Compound) Capecitabine
Capecitabine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypertension worsened
Hypertension worsened {u} (Side Effect) is caused by {v} (Compound) Mycophenolic acid
Mycophenolic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ofloxacin
Celecoxib {u} (Compound) causes {v} (Side Effect) Vitreous floaters
Vitreous floaters {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Paclitaxel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ofloxacin
Celecoxib (Compound) upregulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Ofloxacin (Compound)
Celecoxib (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Ofloxacin (Compound)
Celecoxib (Compound) upregulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Celecoxib (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Ofloxacin (Compound)
Celecoxib (Compound) causes Bullous eruption (Side Effect) and Bullous eruption (Side Effect) is caused by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Ofloxacin (Compound)
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) resembles Vemurafenib (Compound) and Vemurafenib may lead to a major life threatening interaction when taken with Ofloxacin
Celecoxib (Compound) upregulates ERAP2 (Gene) and ERAP2 (Gene) is regulated by RB1 (Gene) and RB1 (Gene) is downregulated by Ofloxacin (Compound)
Celecoxib (Compound) causes Haemorrhoids (Side Effect) and Haemorrhoids (Side Effect) is caused by Capecitabine (Compound) and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin
Celecoxib (Compound) causes Hypertension worsened (Side Effect) and Hypertension worsened (Side Effect) is caused by Mycophenolic acid (Compound) and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin
Celecoxib (Compound) causes Vitreous floaters (Side Effect) and Vitreous floaters (Side Effect) is caused by Paclitaxel (Compound) and Paclitaxel may cause a minor interaction that can limit clinical effects when taken with Ofloxacin