DDInter1938 DDInter1360
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine]. Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.
Vincristine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Oxcarbazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Cerebral haemorrhage
Cerebral haemorrhage {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Vincristine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Carbamazepine
Carbamazepine {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Cerebral haemorrhage
Cerebral haemorrhage {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Oxcarbazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Urine output increased
Urine output increased {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Angiopathy
Angiopathy {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Vincristine {u} (Compound) causes {v} (Side Effect) Menorrhagia
Menorrhagia {u} (Side Effect) is caused by {v} (Compound) Lansoprazole
Lansoprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxcarbazepine
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbamazepine
Carbamazepine {u} (Compound) resembles {v} (Compound) Oxcarbazepine
Vincristine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Oxcarbazepine (Compound)
Vincristine (Compound) causes Cerebral haemorrhage (Side Effect) and Cerebral haemorrhage (Side Effect) is caused by Oxcarbazepine (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Vincristine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Carbamazepine (Compound) and Carbamazepine (Compound) resembles Oxcarbazepine (Compound)
Vincristine (Compound) causes Cerebral haemorrhage (Side Effect) and Cerebral haemorrhage (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Oxcarbazepine
Vincristine (Compound) causes Urine output increased (Side Effect) and Urine output increased (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Vincristine (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Vincristine (Compound) causes Menorrhagia (Side Effect) and Menorrhagia (Side Effect) is caused by Lansoprazole (Compound) and Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Oxcarbazepine (Compound)