DDInter1294 DDInter1476
Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established. The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Nilutamide {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Pirbuterol
Nilutamide {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Terbutaline
Terbutaline {u} (Compound) resembles {v} (Compound) Pirbuterol
Nilutamide {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Salbutamol
Salbutamol {u} (Compound) resembles {v} (Compound) Pirbuterol
Nilutamide {u} (Compound) resembles {v} (Compound) Flutamide
Flutamide {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Pirbuterol
Nilutamide {u} (Compound) resembles {v} (Compound) Enzalutamide
Enzalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Salbutamol {u} (Compound) resembles {v} (Compound) Pirbuterol
Nilutamide {u} (Compound) treats {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is associated with {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Pirbuterol
Nilutamide {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Epinephrine
Epinephrine {u} (Compound) resembles {v} (Compound) Pirbuterol
Nilutamide (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Pirbuterol (Compound)
Nilutamide (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Terbutaline (Compound) and Terbutaline (Compound) resembles Pirbuterol (Compound)
Nilutamide (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Salbutamol (Compound) and Salbutamol (Compound) resembles Pirbuterol (Compound)
Nilutamide (Compound) resembles Flutamide (Compound) and Flutamide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pirbuterol (Compound)
Nilutamide (Compound) resembles Enzalutamide (Compound) and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol (Compound) resembles Pirbuterol (Compound)
Nilutamide (Compound) treats prostate cancer (Disease) and prostate cancer (Disease) is associated with ADRB2 (Gene) and ADRB2 (Gene) is bound by Pirbuterol (Compound)
Nilutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Epinephrine (Compound) and Epinephrine (Compound) resembles Pirbuterol (Compound)