DDInter1662 DDInter1464
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Digitoxin
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Entrectinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trimipramine
Trimipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may lead to a major life threatening interaction when taken with {v} Cabozantinib
Cabozantinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Digitoxin
Digitoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Midostaurin
Midostaurin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) downregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Lincomycin
Lincomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Molindone
Molindone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sertraline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digitoxin (Compound) and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sertraline (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Digitoxin (Compound) and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Sertraline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trimipramine (Compound) and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sertraline (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Digitoxin (Compound) and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sertraline (Compound) downregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Lincomycin (Compound) and Lincomycin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sertraline (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Molindone (Compound) and Molindone may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid