DDInter458 DDInter1968
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid was first described in the literature in 1994. Zoledronic acid was granted FDA approval on 20 August 2001.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephropathy toxic
Nephropathy toxic {u} (Side Effect) is caused by {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zoledronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nephropathy toxic
Nephropathy toxic {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zoledronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) SLC25A4
SLC25A4 {u} (Gene) is bound by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is regulated by {v} (Gene) GGPS1
GGPS1 {u} (Gene) is bound by {v} (Compound) Zoledronic acid
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Zoledronic acid
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Zoledronic acid (Compound)
Cyclosporine (Compound) causes Nephropathy toxic (Side Effect) and Nephropathy toxic (Side Effect) is caused by Zoledronic acid (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid
Cyclosporine (Compound) causes Nephropathy toxic (Side Effect) and Nephropathy toxic (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Zoledronic acid (Compound)
Cyclosporine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Ibandronate (Compound) and Ibandronate (Compound) resembles Zoledronic acid (Compound)
Cyclosporine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid
Cyclosporine (Compound) downregulates SLC25A4 (Gene) and SLC25A4 (Gene) is bound by Clodronate (Compound) and Clodronate (Compound) resembles Zoledronic acid (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Clodronate (Compound) and Clodronate (Compound) resembles Zoledronic acid (Compound)
Cyclosporine (Compound) downregulates PCNA (Gene) and PCNA (Gene) is regulated by GGPS1 (Gene) and GGPS1 (Gene) is bound by Zoledronic acid (Compound)
Cyclosporine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Zoledronic acid