DDInter535 DDInter65
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Amifostine
Diazoxide {u} (Compound) causes {v} (Side Effect) Sensation of warmth
Sensation of warmth {u} (Side Effect) is caused by {v} (Compound) Amifostine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ENPP1
ENPP1 {u} (Gene) is bound by {v} (Compound) Amifostine
Diazoxide {u} (Compound) causes {v} (Side Effect) Sensation of warmth
Sensation of warmth {u} (Side Effect) is caused by {v} (Compound) Isosorbide mononitrate
Isosorbide mononitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Minoxidil
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Amifostine
Diazoxide {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Amifostine
Diazoxide {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amifostine
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Amifostine
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Amifostine (Compound)
Diazoxide (Compound) causes Sensation of warmth (Side Effect) and Sensation of warmth (Side Effect) is caused by Amifostine (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ENPP1 (Gene) and ENPP1 (Gene) is bound by Amifostine (Compound)
Diazoxide (Compound) causes Sensation of warmth (Side Effect) and Sensation of warmth (Side Effect) is caused by Isosorbide mononitrate (Compound) and Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Minoxidil (Compound) and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Amifostine (Compound)
Diazoxide (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Amifostine (Compound)
Diazoxide (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Amifostine (Compound)