DDInter576 DDInter769
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct from the fungal derivatives of this therapeutic class. Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) downregulates {v} (Gene) PPP2R5A
PPP2R5A {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is downregulated by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Pitavastatin
Pitavastatin {u} (Compound) resembles {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rosuvastatin
Rosuvastatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluvastatin
Disulfiram {u} (Compound) downregulates {v} (Gene) PPP2R5A
PPP2R5A {u} (Gene) is regulated by {v} (Gene) RHOA
RHOA {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Disulfiram {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) regulates {v} (Gene) GPER1
GPER1 {u} (Gene) is upregulated by {v} (Compound) Fluvastatin
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fluvastatin (Compound)
Disulfiram (Compound) downregulates PPP2R5A (Gene) and PPP2R5A (Gene) is upregulated by Fluvastatin (Compound)
Disulfiram (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Fluvastatin (Compound)
Disulfiram (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Fluvastatin (Compound)
Disulfiram (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is downregulated by Fluvastatin (Compound)
Disulfiram (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Fluvastatin (Compound)
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Pitavastatin (Compound) and Pitavastatin (Compound) resembles Fluvastatin (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rosuvastatin (Compound) and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin
Disulfiram (Compound) downregulates PPP2R5A (Gene) and PPP2R5A (Gene) is regulated by RHOA (Gene) and RHOA (Gene) is upregulated by Fluvastatin (Compound)
Disulfiram (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) regulates GPER1 (Gene) and GPER1 (Gene) is upregulated by Fluvastatin (Compound)