DDInter1174 DDInter1266
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Naproxen
Methotrexate {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Naproxen
Methotrexate {u} (Compound) upregulates {v} (Gene) FAM63A
FAM63A {u} (Gene) is upregulated by {v} (Compound) Naproxen
Methotrexate {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is palliated by {v} (Compound) Naproxen
Methotrexate {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Naproxen
Methotrexate {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Naproxen
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Naproxen
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) resembles {v} (Compound) Naproxen
Methotrexate {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Naproxen
Methotrexate may lead to a major life threatening interaction when taken with Nabumetone and Nabumetone (Compound) resembles Naproxen (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Naproxen (Compound)
Methotrexate (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Naproxen (Compound)
Methotrexate (Compound) upregulates FAM63A (Gene) and FAM63A (Gene) is upregulated by Naproxen (Compound)
Methotrexate (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is palliated by Naproxen (Compound)
Methotrexate (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Naproxen (Compound)
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Naproxen (Compound) and PTGS2 (Gene) is upregulated by Naproxen (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Nabumetone and Nabumetone (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Naproxen (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen (Compound) resembles Suprofen (Compound) and Suprofen (Compound) resembles Naproxen (Compound)
Methotrexate (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ketoprofen (Compound) and Ketoprofen (Compound) resembles Naproxen (Compound)