DDInter1291 DDInter1652
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer durations of action. The most popular of the third generation dihydropyridines is [amlodipine]. Nifedipine was granted FDA approval on 31 December 1981.
Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.[L39600,L42280,L48771]
Nifedipine {u} (Compound) resembles {v} (Compound) Isradipine
Nifedipine {u} (Compound) resembles {v} (Compound) Nicardipine
Nifedipine {u} (Compound) treats {v} (Disease) hypertension
Nifedipine {u} (Compound) binds {v} (Gene) CALM1
Nifedipine {u} (Compound) upregulates {v} (Gene) MTHFD2
Nifedipine {u} (Compound) palliates {v} (Disease) systemic scleroderma
Nifedipine {u} (Compound) is included by {v} (Pharmacologic Class) Dihydropyridines
Nifedipine {u} (Compound) downregulates {v} (Gene) FOXO4
Nifedipine {u} (Compound) causes {v} (Side Effect) Sleep disorder
Nifedipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Darolutamide
Nifedipine (Compound) resembles Isradipine (Compound)
Nifedipine (Compound) resembles Nicardipine (Compound)
Nifedipine (Compound) treats hypertension (Disease)
Nifedipine (Compound) binds CALM1 (Gene)
Nifedipine (Compound) upregulates MTHFD2 (Gene)
Nifedipine (Compound) palliates systemic scleroderma (Disease)
Nifedipine (Compound) is included by Dihydropyridines (Pharmacologic Class)
Nifedipine (Compound) downregulates FOXO4 (Gene)
Nifedipine (Compound) causes Sleep disorder (Side Effect)
Nifedipine may cause a minor interaction that can limit clinical effects when taken with Darolutamide