DDInter1209 DDInter119
Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of fungal CYP450 14α-lanosterol demethylase activity.[A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.[A214523, L14021] It is currently available as a variety of prescription and over the counter products. Despite having been in clinical use for an extended period, resistance to m
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Miconazole {u} (Compound) resembles {v} (Compound) Tioconazole
Miconazole {u} (Compound) resembles {v} (Compound) Triclosan
Miconazole {u} (Compound) binds {v} (Gene) KCNMB1
Miconazole {u} (Compound) upregulates {v} (Gene) KIT
Miconazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Miconazole {u} (Compound) downregulates {v} (Gene) STUB1
Miconazole {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Escitalopram
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tofacitinib
Miconazole (Compound) resembles Tioconazole (Compound)
Miconazole (Compound) resembles Triclosan (Compound)
Miconazole (Compound) binds KCNMB1 (Gene)
Miconazole (Compound) upregulates KIT (Gene)
Miconazole (Compound) is included by Azoles (Pharmacologic Class)
Miconazole (Compound) downregulates STUB1 (Gene)
Miconazole (Compound) causes Mediastinal disorder (Side Effect)
Miconazole may cause a minor interaction that can limit clinical effects when taken with Escitalopram
Miconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib