DDInter1943 DDInter255
In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are currently being researched for use in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage. Though this research is so far inconclusive, vitamin E remains a popular supplement and is generally considered safe by the FDA[FDA Label].
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Vitamin E {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Vitamin E {u} (Compound) resembles {v} (Compound) Phylloquinone
Phylloquinone {u} (Compound) causes {v} (Side Effect) Atrophy
Atrophy {u} (Side Effect) is caused by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) GSTA2
GSTA2 {u} (Gene) interacts with {v} (Gene) GSTA1
GSTA1 {u} (Gene) is bound by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) regulates {v} (Gene) NUDT9
NUDT9 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) GCLC
GCLC {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) SEC14L2
SEC14L2 {u} (Gene) is regulated by {v} (Gene) CDK4
CDK4 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) PRKCA
PRKCA {u} (Gene) interacts with {v} (Gene) STXBP1
STXBP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) PRKCA
PRKCA {u} (Gene) interacts with {v} (Gene) TERT
TERT {u} (Gene) is upregulated by {v} (Compound) Busulfan
Vitamin E {u} (Compound) binds {v} (Gene) PRKCA
PRKCA {u} (Gene) interacts with {v} (Gene) POLB
POLB {u} (Gene) is upregulated by {v} (Compound) Busulfan
Vitamin E (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is bound by Busulfan (Compound)
Vitamin E (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Vitamin E (Compound) resembles Phylloquinone (Compound) and Phylloquinone (Compound) causes Atrophy (Side Effect) and Atrophy (Side Effect) is caused by Busulfan (Compound)
Vitamin E (Compound) binds GSTA2 (Gene) and GSTA2 (Gene) interacts with GSTA1 (Gene) and GSTA1 (Gene) is bound by Busulfan (Compound)
Vitamin E (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) regulates NUDT9 (Gene) and NUDT9 (Gene) is upregulated by Busulfan (Compound)
Vitamin E (Compound) binds GCLC (Gene) and GCLC (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Busulfan (Compound)
Vitamin E (Compound) binds SEC14L2 (Gene) and SEC14L2 (Gene) is regulated by CDK4 (Gene) and CDK4 (Gene) is downregulated by Busulfan (Compound)
Vitamin E (Compound) binds PRKCA (Gene) and PRKCA (Gene) interacts with STXBP1 (Gene) and STXBP1 (Gene) is downregulated by Busulfan (Compound)
Vitamin E (Compound) binds PRKCA (Gene) and PRKCA (Gene) interacts with TERT (Gene) and TERT (Gene) is upregulated by Busulfan (Compound)
Vitamin E (Compound) binds PRKCA (Gene) and PRKCA (Gene) interacts with POLB (Gene) and POLB (Gene) is upregulated by Busulfan (Compound)