DDInter716 DDInter1544
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Felodipine {u} (Compound) resembles {v} (Compound) Amlodipine
Felodipine {u} (Compound) resembles {v} (Compound) Isradipine
Felodipine {u} (Compound) treats {v} (Disease) hypertension
Felodipine {u} (Compound) binds {v} (Gene) CACNA1S
Felodipine {u} (Compound) upregulates {v} (Gene) CGRRF1
Felodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Felodipine {u} (Compound) downregulates {v} (Gene) GJA1
Felodipine {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Felodipine (Compound) resembles Amlodipine (Compound)
Felodipine (Compound) resembles Isradipine (Compound)
Felodipine (Compound) treats hypertension (Disease)
Felodipine (Compound) binds CACNA1S (Gene)
Felodipine (Compound) upregulates CGRRF1 (Gene)
Felodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Felodipine (Compound) downregulates GJA1 (Gene)
Felodipine (Compound) causes Sexual dysfunction (Side Effect)
Felodipine may cause a minor interaction that can limit clinical effects when taken with Theophylline
Felodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor