DDInter1639 DDInter1918
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum. PDE5 inhibitors, such as vardenafil, inhibit the degradation of cGMP and allow increased blood flow into the penis, resulting in an erection.[A258303,L45563,L45568]. Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil. The FDA approved the use of vardenafil for the treatment of erectile dysfunction in 2003. Although other PDE5 inhibitors such as [sildenafil] and [tadalafil] have been associated with rare cases of acute liver injury, the use of vardenafil has not been linked to hepatotoxic effects. The use of vardenafil as a monotherapy for the treatment of pulmonary arterial hypertension has also been evaluated.
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Vardenafil
Sapropterin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Vardenafil
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) regulates {v} (Gene) ABCC5
ABCC5 {u} (Gene) is upregulated by {v} (Compound) Vardenafil
Sapropterin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Sildenafil
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Sapropterin {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Sapropterin {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is upregulated by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Sapropterin {u} (Compound) upregulates {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Daunorubicin
Daunorubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Vardenafil (Compound)
Sapropterin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Vardenafil (Compound)
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) regulates ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Vardenafil (Compound)
Sapropterin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Sildenafil (Compound) and Sildenafil (Compound) resembles Vardenafil (Compound)
Sapropterin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is bound by Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Sapropterin (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is upregulated by Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Sapropterin (Compound) upregulates GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Daunorubicin (Compound) and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil