DDInter458 DDInter1406
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine. FDA approved March 27, 2012.
Cyclosporine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is upregulated by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Serum creatinine increased
Serum creatinine increased {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Peginesatide
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Carfilzomib {u} may lead to a major life threatening interaction when taken with {v} Peginesatide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hearing impaired
Hearing impaired {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Peginesatide
Cyclosporine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Captopril
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Captopril
Captopril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Peginesatide
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCND3
CCND3 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Peginesatide
Cyclosporine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is upregulated by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Cyclosporine (Compound) causes Serum creatinine increased (Side Effect) and Serum creatinine increased (Side Effect) is caused by Enalapril (Compound) and Enalapril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Cyclosporine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Peginesatide
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound) and Carfilzomib may lead to a major life threatening interaction when taken with Peginesatide
Cyclosporine (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Peginesatide
Cyclosporine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Captopril (Compound) and Captopril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Captopril (Compound) and Captopril may cause a minor interaction that can limit clinical effects when taken with Peginesatide
Cyclosporine (Compound) downregulates CCND3 (Gene) and CCND3 (Gene) is upregulated by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Peginesatide