DDInter1084 DDInter255
Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gatifloxacin
Gatifloxacin {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) resembles {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) upregulates {v} (Gene) WRB
WRB {u} (Gene) is downregulated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) regulates {v} (Gene) MAMLD1
MAMLD1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) resembles {v} (Compound) Gemifloxacin
Gemifloxacin {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Lomefloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is regulated by {v} (Gene) GPER1
GPER1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Lomefloxacin (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Lomefloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Lomefloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Busulfan (Compound)
Lomefloxacin (Compound) resembles Sparfloxacin (Compound) and Sparfloxacin (Compound) upregulates WRB (Gene) and WRB (Gene) is downregulated by Busulfan (Compound)
Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) regulates MAMLD1 (Gene) and MAMLD1 (Gene) is upregulated by Busulfan (Compound)
Lomefloxacin (Compound) resembles Gemifloxacin (Compound) and Gemifloxacin (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Busulfan (Compound)
Lomefloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is regulated by GPER1 (Gene) and GPER1 (Gene) is upregulated by Busulfan (Compound)