DDInter1305 DDInter513
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone]. Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) GUCY1A2
GUCY1A2 {u} (Gene) is associated with {v} (Disease) breast cancer
breast cancer {u} (Disease) is palliated by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Clobetasol propionate
Clobetasol propionate {u} (Compound) resembles {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) interacts with {v} (Gene) JUN
JUN {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) NPR1
NPR1 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) TIPARP
TIPARP {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) interacts with {v} (Gene) CYB5A
CYB5A {u} (Gene) is upregulated by {v} (Compound) Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Albendazole
Albendazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Nitroprusside {u} (Compound) binds {v} (Gene) ACHE
ACHE {u} (Gene) covaries with {v} (Gene) LARP6
LARP6 {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Dexamethasone (Compound)
Nitroprusside (Compound) binds GUCY1A2 (Gene) and GUCY1A2 (Gene) is associated with breast cancer (Disease) and breast cancer (Disease) is palliated by Dexamethasone (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Clobetasol propionate (Compound) and Clobetasol propionate (Compound) resembles Dexamethasone (Compound)
Nitroprusside (Compound) binds ACHE (Gene) and ACHE (Gene) interacts with JUN (Gene) and JUN (Gene) is downregulated by Dexamethasone (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Dexamethasone (Compound)
Nitroprusside (Compound) binds NPR1 (Gene) and NPR1 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dexamethasone (Compound)
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates TIPARP (Gene) and TIPARP (Gene) is upregulated by Dexamethasone (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) interacts with CYB5A (Gene) and CYB5A (Gene) is upregulated by Dexamethasone (Compound)
Nitroprusside (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Albendazole (Compound) and Albendazole may cause a minor interaction that can limit clinical effects when taken with Dexamethasone
Nitroprusside (Compound) binds ACHE (Gene) and ACHE (Gene) covaries with LARP6 (Gene) and LARP6 (Gene) is downregulated by Dexamethasone (Compound)