DDInter1678 DDInter1759
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azilsartan medoxomil
Azilsartan medoxomil {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Losartan
Losartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Telmisartan
Sirolimus {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Telmisartan
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Azilsartan medoxomil
Azilsartan medoxomil {u} (Compound) resembles {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Losartan
Losartan {u} (Compound) resembles {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} (Compound) downregulates {v} (Gene) TATDN2
TATDN2 {u} (Gene) is upregulated by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Azilsartan medoxomil and Azilsartan medoxomil (Compound) resembles Telmisartan (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Telmisartan (Compound)
Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Telmisartan (Compound)
Sirolimus (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telmisartan (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Azilsartan medoxomil and Azilsartan medoxomil (Compound) resembles Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Sirolimus (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Sirolimus (Compound) downregulates TATDN2 (Gene) and TATDN2 (Gene) is upregulated by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Sirolimus (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)