DDInter1397 DDInter1609
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Rivaroxaban
Paroxetine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Rivaroxaban
Paroxetine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rivaroxaban
Paroxetine {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Linezolid
Linezolid {u} (Compound) resembles {v} (Compound) Rivaroxaban
Paroxetine {u} (Compound) causes {v} (Side Effect) Urinary tract infection
Urinary tract infection {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rivaroxaban
Paroxetine {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rivaroxaban
Paroxetine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Compound) Linezolid
Linezolid {u} (Compound) resembles {v} (Compound) Rivaroxaban
Paroxetine {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) interacts with {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Rivaroxaban
Paroxetine {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Hepatic function abnormal {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Rivaroxaban
Paroxetine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is regulated by {v} (Gene) SHB
SHB {u} (Gene) is downregulated by {v} (Compound) Rivaroxaban
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Paroxetine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Paroxetine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Paroxetine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Linezolid (Compound) and Linezolid (Compound) resembles Rivaroxaban (Compound)
Paroxetine (Compound) causes Urinary tract infection (Side Effect) and Urinary tract infection (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rivaroxaban
Paroxetine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Paroxetine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by Linezolid (Compound) and Linezolid (Compound) resembles Rivaroxaban (Compound)
Paroxetine (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) interacts with CDK6 (Gene) and CDK6 (Gene) is upregulated by Rivaroxaban (Compound)
Paroxetine (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Rivaroxaban
Paroxetine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is regulated by SHB (Gene) and SHB (Gene) is downregulated by Rivaroxaban (Compound)