DDInter671 DDInter458
Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow [FDA Label]. Epoetin alfa (Epoge) was developed by Amgen Inc. in 1983 as the first rhEPO commercialized in the United States, followed by other alfa and beta formulations. Epoetin alfa is a 165-amino acid erythropoiesis-stimulating glycoprotein produced in cell culture using recombinant DNA technology and is used for the treatment of patients with anemia associated with various clinical conditions, such as chronic renal failure, antiviral drug therapy, chemotherapy, or a high risk for perioperative blood loss from surgical procedures [FDA Label]. It has a molecular weight of approximately 30,400 daltons and is produced by mammalian cells into which the human erythropo
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Perindopril
Perindopril {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cyclosporine
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinapril
Quinapril {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Cyclosporine
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Perindopril
Perindopril {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Erythropoietin {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Cyclosporine
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) downregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Erythropoietin {u} may lead to a major life threatening interaction when taken with {v} Lenalidomide
Lenalidomide {u} (Compound) causes {v} (Side Effect) Hearing impaired
Hearing impaired {u} (Side Effect) is caused by {v} (Compound) Cyclosporine
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Captopril
Captopril {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Erythropoietin {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Erythropoietin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enalapril
Enalapril {u} (Compound) upregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Erythropoietin {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Thalidomide {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Perindopril and Perindopril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cyclosporine (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Quinapril and Quinapril (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Cyclosporine (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Perindopril and Perindopril (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Cyclosporine (Compound)
Erythropoietin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cyclosporine (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) downregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Cyclosporine (Compound)
Erythropoietin may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Cyclosporine (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Captopril and Captopril (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Cyclosporine (Compound)
Erythropoietin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Cyclosporine (Compound)
Erythropoietin may cause a minor interaction that can limit clinical effects when taken with Enalapril and Enalapril (Compound) upregulates CRYZ (Gene) and CRYZ (Gene) is downregulated by Cyclosporine (Compound)
Erythropoietin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Cyclosporine (Compound)