DDInter458 DDInter1313
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST7
ST7 {u} (Gene) is upregulated by {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Pefloxacin
Pefloxacin {u} (Compound) resembles {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST7
ST7 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is regulated by {v} (Gene) ISOC1
ISOC1 {u} (Gene) is downregulated by {v} (Compound) Norfloxacin
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Norfloxacin (Compound)
Cyclosporine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Norfloxacin (Compound)
Cyclosporine (Compound) upregulates ST7 (Gene) and ST7 (Gene) is upregulated by Norfloxacin (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Norfloxacin (Compound)
Cyclosporine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Norfloxacin (Compound)
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Norfloxacin (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound) and Levofloxacin (Compound) resembles Norfloxacin (Compound)
Cyclosporine (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is bound by Pefloxacin (Compound) and Pefloxacin (Compound) resembles Norfloxacin (Compound)
Cyclosporine (Compound) upregulates ST7 (Gene) and ST7 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Norfloxacin (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is regulated by ISOC1 (Gene) and ISOC1 (Gene) is downregulated by Norfloxacin (Compound)