DDInter1938 DDInter782
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form of netupitant [FDA label]. Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality and 70% to 80% of these patients undergoing chemotherapy treatment may experience nausea and vomiting as major side effects. Considered one of the most distressing side effects of chemotherapy, nausea and vomiting has an immense impact on the quality of life of patients receiving certain antineoplastic therapies .
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vincristine {u} (Compound) resembles {v} (Compound) Voacamine
Vincristine {u} (Compound) treats {v} (Disease) muscle cancer
Vincristine {u} (Compound) binds {v} (Gene) TUBB
Vincristine {u} (Compound) upregulates {v} (Gene) TICAM1
Vincristine {u} (Compound) is included by {v} (Pharmacologic Class) Vinca Alkaloids
Vincristine {u} (Compound) downregulates {v} (Gene) BRCA1
Vincristine {u} (Compound) causes {v} (Side Effect) Respiratory distress
Vincristine {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) TUBB2A
Vincristine (Compound) resembles Vinorelbine (Compound)
Vincristine (Compound) resembles Voacamine (Compound)
Vincristine (Compound) treats muscle cancer (Disease)
Vincristine (Compound) binds TUBB (Gene)
Vincristine (Compound) upregulates TICAM1 (Gene)
Vincristine (Compound) is included by Vinca Alkaloids (Pharmacologic Class)
Vincristine (Compound) downregulates BRCA1 (Gene)
Vincristine (Compound) causes Respiratory distress (Side Effect)
Vincristine (Compound) binds TUBB2A (Gene) and Vincristine (Compound) upregulates TUBB2A (Gene)