DDInter1562 DDInter869
Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific effects distinct from [estradiol], raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM. Available in many countries worldwide, raloxifene was initially approved by the FDA in December, 1997 under the market name Evista® for the management and prevention of osteoporosis in postmenopausal women and reduction in risk for invasive breast cancer in postmenopausal women with osteoporosis or those who are at high risk for invasive breast cancer. However, it has a negligible effect on altering the development and progression of breast cancer itself.[label] The most common causes of osteoporosis
C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and treatment of Hereditary Angioedema (HAE), a human genetic disorder caused by a shortage of C1 inhibitor activity that results in an overreaction of the immune system. The disease is characterized by acute attacks of painful, and in some cases, fatal swelling of several soft tissues or edema, which may last up to five days when untreated.[L16586, L16606]
Raloxifene {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is bound by {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) causes {v} (Side Effect) Blood pressure increased
Blood pressure increased {u} (Side Effect) is caused by {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) binds {v} (Gene) CYP19A1
CYP19A1 {u} (Gene) is bound by {v} (Compound) Methyltestosterone
Methyltestosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Methyltestosterone
Methyltestosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Carfilzomib
Carfilzomib {u} may lead to a major life threatening interaction when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may lead to a major life threatening interaction when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) treats {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is treated by {v} (Compound) Estradiol
Estradiol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) upregulates {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Estradiol
Estradiol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) treats {v} (Disease) osteoporosis
osteoporosis {u} (Disease) is palliated by {v} (Compound) Oxandrolone
Oxandrolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Estradiol
Estradiol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Raloxifene (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) causes Blood pressure increased (Side Effect) and Blood pressure increased (Side Effect) is caused by Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Carfilzomib (Compound) and Carfilzomib may lead to a major life threatening interaction when taken with Human C1-esterase inhibitor
Raloxifene (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may lead to a major life threatening interaction when taken with Human C1-esterase inhibitor
Raloxifene (Compound) treats osteoporosis (Disease) and osteoporosis (Disease) is treated by Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) upregulates CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) treats osteoporosis (Disease) and osteoporosis (Disease) is palliated by Oxandrolone (Compound) and Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Raloxifene (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor