DDInter458 DDInter722
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and [oxycodone]. Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily. Fentanyl was FDA approved in 1968.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Fentanyl
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Alfentanil
Alfentanil {u} (Compound) resembles {v} (Compound) Fentanyl
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Loperamide
Loperamide {u} (Compound) resembles {v} (Compound) Fentanyl
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fentanyl
Cyclosporine {u} (Compound) causes {v} (Side Effect) Breath sounds abnormal
Breath sounds abnormal {u} (Side Effect) is caused by {v} (Compound) Propafenone
Propafenone {u} (Compound) resembles {v} (Compound) Fentanyl
Cyclosporine {u} (Compound) causes {v} (Side Effect) Sepsis
Sepsis {u} (Side Effect) is caused by {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fentanyl
Cyclosporine {u} (Compound) causes {v} (Side Effect) Cellulitis
Cellulitis {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fentanyl
Cyclosporine {u} (Compound) causes {v} (Side Effect) Night sweats
Night sweats {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Fentanyl
Cyclosporine {u} (Compound) treats {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Dexamethasone
Dexamethasone {u} may lead to a major life threatening interaction when taken with {v} Fentanyl
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Fentanyl (Compound)
Cyclosporine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Fentanyl (Compound)
Cyclosporine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Alfentanil (Compound) and Alfentanil (Compound) resembles Fentanyl (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Loperamide (Compound) and Loperamide (Compound) resembles Fentanyl (Compound)
Cyclosporine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Modafinil (Compound) and Modafinil (Compound) resembles Fentanyl (Compound)
Cyclosporine (Compound) causes Breath sounds abnormal (Side Effect) and Breath sounds abnormal (Side Effect) is caused by Propafenone (Compound) and Propafenone (Compound) resembles Fentanyl (Compound)
Cyclosporine (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl
Cyclosporine (Compound) causes Cellulitis (Side Effect) and Cellulitis (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl
Cyclosporine (Compound) causes Night sweats (Side Effect) and Night sweats (Side Effect) is caused by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Fentanyl
Cyclosporine (Compound) treats systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Dexamethasone (Compound) and Dexamethasone may lead to a major life threatening interaction when taken with Fentanyl