DDInter336 DDInter1471
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the early 1970s. Pindolol was granted FDA approval on 3 September 1982.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pindolol
Celecoxib {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is downregulated by {v} (Compound) Pindolol
Celecoxib {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Pindolol
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Betaxolol
Betaxolol {u} (Compound) resembles {v} (Compound) Pindolol
Celecoxib {u} (Compound) downregulates {v} (Gene) RTN2
RTN2 {u} (Gene) is downregulated by {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Pindolol
Celecoxib {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Betaxolol
Betaxolol {u} (Compound) resembles {v} (Compound) Pindolol
Celecoxib {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Atenolol
Atenolol {u} (Compound) resembles {v} (Compound) Pindolol
Celecoxib {u} (Compound) causes {v} (Side Effect) Pollakiuria
Pollakiuria {u} (Side Effect) is caused by {v} (Compound) Glimepiride
Glimepiride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pindolol
Celecoxib {u} (Compound) resembles {v} (Compound) Sulfaphenazole
Sulfaphenazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Pindolol
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Pindolol
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pindolol (Compound)
Celecoxib (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is downregulated by Pindolol (Compound)
Celecoxib (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Pindolol (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Betaxolol (Compound) and Betaxolol (Compound) resembles Pindolol (Compound)
Celecoxib (Compound) downregulates RTN2 (Gene) and RTN2 (Gene) is downregulated by Oxprenolol (Compound) and Oxprenolol (Compound) resembles Pindolol (Compound)
Celecoxib (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Betaxolol (Compound) and Betaxolol (Compound) resembles Pindolol (Compound)
Celecoxib (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Atenolol (Compound) and Atenolol (Compound) resembles Pindolol (Compound)
Celecoxib (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Glimepiride (Compound) and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Pindolol
Celecoxib (Compound) resembles Sulfaphenazole (Compound) and Sulfaphenazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pindolol (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Acebutolol (Compound) and Acebutolol (Compound) resembles Pindolol (Compound)