DDInter1397 DDInter1168
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Paroxetine {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Paroxetine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Paroxetine {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Epinastine
Epinastine {u} (Compound) resembles {v} (Compound) Methdilazine
Paroxetine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Biperiden
Biperiden {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Paroxetine {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Thioproperazine
Thioproperazine {u} (Compound) resembles {v} (Compound) Methdilazine
Paroxetine {u} (Compound) binds {v} (Gene) HTR2A
HTR2A {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Paroxetine {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Biperiden
Biperiden {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Paroxetine {u} (Compound) upregulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Methdilazine
Paroxetine {u} (Compound) downregulates {v} (Gene) MRPL19
MRPL19 {u} (Gene) is downregulated by {v} (Compound) Methyldopa
Methyldopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Paroxetine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Methdilazine
Paroxetine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Paroxetine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Paroxetine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Epinastine (Compound) and Epinastine (Compound) resembles Methdilazine (Compound)
Paroxetine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Biperiden (Compound) and Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Paroxetine (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Thioproperazine (Compound) and Thioproperazine (Compound) resembles Methdilazine (Compound)
Paroxetine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Paroxetine (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Biperiden (Compound) and Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Paroxetine (Compound) upregulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Thioridazine (Compound) and Thioridazine (Compound) resembles Methdilazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken with Methdilazine
Paroxetine (Compound) downregulates MRPL19 (Gene) and MRPL19 (Gene) is downregulated by Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Paroxetine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Triflupromazine (Compound) and Triflupromazine (Compound) resembles Methdilazine (Compound)