DDInter55 DDInter856
Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used in men for whom oral treatment is either contraindicated or ineffective. After administration, alprostadil promotes smooth muscle relaxation of the corpus cavernosal.[A257068,A257088] Alprostadil is also used in neonatal patients with congenital heart defects that depend on a patent ductus for survival until corrective or palliative surgery can be performed. This drug causes vasodilation by directly affecting vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Alprostadil {u} (Compound) resembles {v} (Compound) Dinoprost Tromethamine
Alprostadil {u} (Compound) resembles {v} (Compound) Ethanolamine Oleate
Alprostadil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epoprostenol
Alprostadil {u} (Compound) binds {v} (Gene) SLCO2B1
Alprostadil {u} (Compound) upregulates {v} (Gene) CLPX
Alprostadil {u} (Compound) is included by {v} (Pharmacologic Class) Prostaglandin Receptor Agonists
Alprostadil {u} (Compound) causes {v} (Side Effect) Prostatic disorder
Alprostadil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Alprostadil (Compound) resembles Dinoprost Tromethamine (Compound)
Alprostadil (Compound) resembles Ethanolamine Oleate (Compound)
Alprostadil may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol
Alprostadil (Compound) binds SLCO2B1 (Gene)
Alprostadil (Compound) upregulates CLPX (Gene)
Alprostadil (Compound) is included by Prostaglandin Receptor Agonists (Pharmacologic Class)
Alprostadil (Compound) causes Prostatic disorder (Side Effect)
Alprostadil may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil