DDInter1610 DDInter1789
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Rivastigmine {u} (Compound) upregulates {v} (Gene) FGFR2
FGFR2 {u} (Gene) is bound by {v} (Compound) Thalidomide
Rivastigmine {u} (Compound) causes {v} (Side Effect) Myocardial ischaemia
Myocardial ischaemia {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Rivastigmine {u} (Compound) resembles {v} (Compound) Tapentadol
Tapentadol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Rivastigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Pyridostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Rivastigmine {u} (Compound) upregulates {v} (Gene) FGFR2
FGFR2 {u} (Gene) is regulated by {v} (Gene) SMARCD2
SMARCD2 {u} (Gene) is upregulated by {v} (Compound) Thalidomide
Rivastigmine {u} (Compound) causes {v} (Side Effect) Myocardial ischaemia
Myocardial ischaemia {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Thalidomide
Rivastigmine {u} (Compound) causes {v} (Side Effect) Emphysema
Emphysema {u} (Side Effect) is caused by {v} (Compound) Rasagiline
Rasagiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Rivastigmine {u} (Compound) causes {v} (Side Effect) Neuralgia
Neuralgia {u} (Side Effect) is caused by {v} (Compound) Tizanidine
Tizanidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Rivastigmine {u} (Compound) resembles {v} (Compound) Tapentadol
Tapentadol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Thalidomide
Rivastigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Pyridostigmine {u} (Compound) causes {v} (Side Effect) Musculoskeletal stiffness
Musculoskeletal stiffness {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Rivastigmine (Compound) upregulates FGFR2 (Gene) and FGFR2 (Gene) is bound by Thalidomide (Compound)
Rivastigmine (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Rivastigmine (Compound) resembles Tapentadol (Compound) and Tapentadol may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Rivastigmine (Compound) resembles Pyridostigmine (Compound) and Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Rivastigmine (Compound) upregulates FGFR2 (Gene) and FGFR2 (Gene) is regulated by SMARCD2 (Gene) and SMARCD2 (Gene) is upregulated by Thalidomide (Compound)
Rivastigmine (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Thalidomide (Compound)
Rivastigmine (Compound) causes Emphysema (Side Effect) and Emphysema (Side Effect) is caused by Rasagiline (Compound) and Rasagiline may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Rivastigmine (Compound) causes Neuralgia (Side Effect) and Neuralgia (Side Effect) is caused by Tizanidine (Compound) and Tizanidine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Rivastigmine (Compound) resembles Tapentadol (Compound) and Tapentadol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Thalidomide (Compound)
Rivastigmine (Compound) resembles Pyridostigmine (Compound) and Pyridostigmine (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)