DDInter149 DDInter1747
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Azatadine {u} (Compound) resembles {v} (Compound) Ketotifen
Azatadine {u} (Compound) resembles {v} (Compound) Alcaftadine
Azatadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Azatadine {u} (Compound) binds {v} (Gene) CYP3A4
Azatadine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Hyaluronidase
Azatadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amantadine
Azatadine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Azatadine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Azatadine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amitriptyline
Azatadine (Compound) resembles Ketotifen (Compound)
Azatadine (Compound) resembles Alcaftadine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Azatadine (Compound) binds CYP3A4 (Gene)
Azatadine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Amantadine
Azatadine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Azatadine may lead to a major life threatening interaction when taken with Potassium chloride
Azatadine (Compound) resembles Amitriptyline (Compound) and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline