DDInter1639 DDInter1054
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier[Label,A177781]. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson's[Label]. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975[A177781,L6133].
Sapropterin {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Levodopa
Sapropterin {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Carbidopa
Carbidopa {u} (Compound) resembles {v} (Compound) Levodopa
Sapropterin {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Etoposide
Etoposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) regulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Levodopa
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Levodopa
Sapropterin {u} (Compound) binds {v} (Gene) TH
TH {u} (Gene) is bound by {v} (Compound) L-Phenylalanine
L-Phenylalanine {u} (Compound) resembles {v} (Compound) Levodopa
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is regulated by {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Levodopa
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levodopa
Sapropterin {u} (Compound) binds {v} (Gene) PAH
PAH {u} (Gene) is bound by {v} (Compound) Epinephrine
Epinephrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Levodopa
Sapropterin {u} (Compound) binds {v} (Gene) TH
TH {u} (Gene) is bound by {v} (Compound) L-Tyrosine
L-Tyrosine {u} (Compound) resembles {v} (Compound) Levodopa
Sapropterin (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Levodopa (Compound)
Sapropterin (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Carbidopa (Compound) and Carbidopa (Compound) resembles Levodopa (Compound)
Sapropterin (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Etoposide (Compound) and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) regulates PCNA (Gene) and PCNA (Gene) is downregulated by Levodopa (Compound)
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Melphalan (Compound) and Melphalan (Compound) resembles Levodopa (Compound)
Sapropterin (Compound) binds TH (Gene) and TH (Gene) is bound by L-Phenylalanine (Compound) and L-Phenylalanine (Compound) resembles Levodopa (Compound)
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is regulated by UGDH (Gene) and UGDH (Gene) is downregulated by Levodopa (Compound)
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a minor interaction that can limit clinical effects when taken with Levodopa
Sapropterin (Compound) binds PAH (Gene) and PAH (Gene) is bound by Epinephrine (Compound) and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Sapropterin (Compound) binds TH (Gene) and TH (Gene) is bound by L-Tyrosine (Compound) and L-Tyrosine (Compound) resembles Levodopa (Compound)