DDInter856 DDInter1719
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated hepar
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Sugammadex {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Sugammadex {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Apixaban
Sugammadex {u} may lead to a major life threatening interaction when taken with {v} Norelgestromin
Sugammadex {u} may lead to a major life threatening interaction when taken with {v} Desogestrel
Sugammadex may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Sugammadex may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Sugammadex may lead to a major life threatening interaction when taken with Norelgestromin
Sugammadex may lead to a major life threatening interaction when taken with Desogestrel