DDInter1521 DDInter178
Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Primidone {u} (Compound) resembles {v} (Compound) Phenytoin
Primidone {u} (Compound) treats {v} (Disease) epilepsy syndrome
Primidone {u} (Compound) binds {v} (Gene) CYP2C9
Primidone {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Central Nervous System Disorganized Electrical Activity
Primidone {u} (Compound) downregulates {v} (Gene) OXA1L
Primidone {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Primidone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Calcifediol
Primidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Promethazine
Primidone (Compound) resembles Phenobarbital (Compound)
Primidone (Compound) resembles Phenytoin (Compound)
Primidone (Compound) treats epilepsy syndrome (Disease)
Primidone (Compound) binds CYP2C9 (Gene)
Primidone (Compound) is included by Decreased Central Nervous System Disorganized Electrical Activity (Pharmacologic Class)
Primidone (Compound) downregulates OXA1L (Gene)
Primidone (Compound) causes Psychotic disorder (Side Effect)
Primidone may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Calcifediol
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine