DDInter502 DDInter1376
Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Deserpidine {u} (Compound) resembles {v} (Compound) Yohimbine
Deserpidine {u} (Compound) resembles {v} (Compound) Rescinnamine
Deserpidine {u} (Compound) binds {v} (Gene) SLC18A2
Deserpidine {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Sympathetic Activity
Deserpidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Deserpidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tolbutamide
Deserpidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Iobenguane
Deserpidine (Compound) resembles Yohimbine (Compound)
Deserpidine (Compound) resembles Rescinnamine (Compound)
Deserpidine (Compound) binds SLC18A2 (Gene)
Deserpidine (Compound) is included by Decreased Sympathetic Activity (Pharmacologic Class)
Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine
Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide
Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Deserpidine may lead to a major life threatening interaction when taken with Iobenguane