DDInter1269 DDInter535
Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Nateglinide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Nateglinide {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Diazoxide
Nateglinide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) interacts with {v} (Gene) ABCC8
ABCC8 {u} (Gene) is bound by {v} (Compound) Diazoxide
Nateglinide {u} (Compound) binds {v} (Gene) ABCC8
ABCC8 {u} (Gene) interacts with {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Nateglinide {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroflumethiazide
Hydroflumethiazide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Nateglinide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is palliated by {v} (Compound) Diazoxide
Nateglinide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Nateglinide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)
Nateglinide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Diazoxide (Compound)
Nateglinide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) interacts with ABCC8 (Gene) and ABCC8 (Gene) is bound by Diazoxide (Compound)
Nateglinide (Compound) binds ABCC8 (Gene) and ABCC8 (Gene) interacts with KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)
Nateglinide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Nateglinide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is palliated by Diazoxide (Compound)
Nateglinide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Diazoxide (Compound)