DDInter576 DDInter139
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.
Disulfiram {u} (Compound) upregulates {v} (Gene) CRIP1
CRIP1 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Auranofin
Disulfiram {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is downregulated by {v} (Compound) Auranofin
Disulfiram {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Auranofin
Disulfiram {u} (Compound) upregulates {v} (Gene) CRIP1
CRIP1 {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Auranofin
Disulfiram {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) regulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is bound by {v} (Compound) Auranofin
Disulfiram {u} (Compound) upregulates {v} (Gene) EGR1
EGR1 {u} (Gene) is regulated by {v} (Gene) IKZF1
IKZF1 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Disulfiram {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is regulated by {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Disulfiram {u} (Compound) downregulates {v} (Gene) PSMD9
PSMD9 {u} (Gene) regulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Auranofin
Disulfiram {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) interacts with {v} (Gene) IKBKB
IKBKB {u} (Gene) is bound by {v} (Compound) Auranofin
Disulfiram (Compound) upregulates CRIP1 (Gene) and CRIP1 (Gene) is upregulated by Auranofin (Compound)
Disulfiram (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Auranofin (Compound)
Disulfiram (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is downregulated by Auranofin (Compound)
Disulfiram (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Auranofin (Compound)
Disulfiram (Compound) upregulates CRIP1 (Gene) and CRIP1 (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Auranofin (Compound)
Disulfiram (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) regulates IKBKB (Gene) and IKBKB (Gene) is bound by Auranofin (Compound)
Disulfiram (Compound) upregulates EGR1 (Gene) and EGR1 (Gene) is regulated by IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Auranofin (Compound)
Disulfiram (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is regulated by GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Auranofin (Compound)
Disulfiram (Compound) downregulates PSMD9 (Gene) and PSMD9 (Gene) regulates CPVL (Gene) and CPVL (Gene) is upregulated by Auranofin (Compound)
Disulfiram (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) interacts with IKBKB (Gene) and IKBKB (Gene) is bound by Auranofin (Compound)