DDInter1834 DDInter1427
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. Other forms of pentoxyverine citrate continue to be marketed.
Topiramate {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Nalbuphine
Nalbuphine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) causes {v} (Side Effect) Sensory loss
Sensory loss {u} (Side Effect) is caused by {v} (Compound) Selegiline
Selegiline {u} may lead to a major life threatening interaction when taken with {v} Pentoxyverine
Topiramate {u} (Compound) treats {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) treats {v} (Disease) migraine
migraine {u} (Disease) is palliated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) palliates {v} (Disease) bipolar disorder
bipolar disorder {u} (Disease) is palliated by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Central Nervous System Disorganized Electrical Activity
Decreased Central Nervous System Disorganized Electrical Activity {u} (Pharmacologic Class) includes {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Phenelzine
Phenelzine {u} may lead to a major life threatening interaction when taken with {v} Pentoxyverine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Promazine
Promazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentoxyverine
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Procarbazine
Procarbazine {u} may lead to a major life threatening interaction when taken with {v} Pentoxyverine
Topiramate (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Nalbuphine (Compound) and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) causes Sensory loss (Side Effect) and Sensory loss (Side Effect) is caused by Selegiline (Compound) and Selegiline may lead to a major life threatening interaction when taken with Pentoxyverine
Topiramate (Compound) treats epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) treats migraine (Disease) and migraine (Disease) is palliated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) palliates bipolar disorder (Disease) and bipolar disorder (Disease) is palliated by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) is included by Decreased Central Nervous System Disorganized Electrical Activity (Pharmacologic Class) and Decreased Central Nervous System Disorganized Electrical Activity (Pharmacologic Class) includes Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Phenelzine (Compound) and Phenelzine may lead to a major life threatening interaction when taken with Pentoxyverine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound) and Procarbazine may lead to a major life threatening interaction when taken with Pentoxyverine