DDInter1851 DDInter1016
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of depression. A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy. Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters. It was initially granted FDA approval in 1981.
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Trazodone {u} (Compound) resembles {v} (Compound) Zuclopenthixol
Trazodone {u} (Compound) resembles {v} (Compound) Quetiapine
Trazodone {u} (Compound) binds {v} (Gene) HTR2C
Trazodone {u} (Compound) palliates {v} (Disease) bipolar disorder
Trazodone {u} (Compound) downregulates {v} (Gene) PIN1
Trazodone {u} (Compound) causes {v} (Side Effect) Tachycardia
Trazodone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Trazodone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levothyroxine
Trazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Salbutamol
Trazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinine
Trazodone (Compound) resembles Zuclopenthixol (Compound)
Trazodone (Compound) resembles Quetiapine (Compound)
Trazodone (Compound) binds HTR2C (Gene)
Trazodone (Compound) palliates bipolar disorder (Disease)
Trazodone (Compound) downregulates PIN1 (Gene)
Trazodone (Compound) causes Tachycardia (Side Effect)
Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Trazodone may cause a minor interaction that can limit clinical effects when taken with Levothyroxine
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Quinine