DDInter576 DDInter1918
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis of cGMP in the smooth muscle cells of the corpus cavernosum. PDE5 inhibitors, such as vardenafil, inhibit the degradation of cGMP and allow increased blood flow into the penis, resulting in an erection.[A258303,L45563,L45568]. Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil. The FDA approved the use of vardenafil for the treatment of erectile dysfunction in 2003. Although other PDE5 inhibitors such as [sildenafil] and [tadalafil] have been associated with rare cases of acute liver injury, the use of vardenafil has not been linked to hepatotoxic effects. The use of vardenafil as a monotherapy for the treatment of pulmonary arterial hypertension has also been evaluated.
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Vardenafil
Disulfiram {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Vardenafil
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sildenafil
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Disulfiram {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Sildenafil
Sildenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Disulfiram {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Udenafil
Udenafil {u} (Compound) resembles {v} (Compound) Vardenafil
Disulfiram {u} (Compound) causes {v} (Side Effect) Eye pain
Eye pain {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Disulfiram {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Vardenafil
Disulfiram {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Metronidazole
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Disulfiram {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Palonosetron
Palonosetron {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vardenafil
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vardenafil (Compound)
Disulfiram (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Vardenafil (Compound)
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sildenafil (Compound) and Sildenafil (Compound) resembles Vardenafil (Compound)
Disulfiram (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Sildenafil (Compound) and Sildenafil (Compound) resembles Vardenafil (Compound)
Disulfiram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Udenafil (Compound) and Udenafil (Compound) resembles Vardenafil (Compound)
Disulfiram (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Disulfiram (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Vardenafil
Disulfiram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound) and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Disulfiram (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Palonosetron (Compound) and Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil