DDInter504 DDInter748
Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline and doxepine. TCAs also down-regulate cerebral cortical &beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
Desipramine {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Flumazenil
Desipramine {u} (Compound) resembles {v} (Compound) Doxepin
Doxepin {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Desipramine {u} (Compound) resembles {v} (Compound) Clomipramine
Clomipramine {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Desipramine {u} (Compound) resembles {v} (Compound) Protriptyline
Protriptyline {u} may lead to a major life threatening interaction when taken with {v} Flumazenil
Desipramine {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Zolpidem
Zolpidem {u} may cause a minor interaction that can limit clinical effects when taken with {v} Flumazenil
Desipramine {u} (Compound) causes {v} (Side Effect) Ventricular extrasystoles
Ventricular extrasystoles {u} (Side Effect) is caused by {v} (Compound) Midazolam
Midazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flumazenil
Desipramine {u} (Compound) resembles {v} (Compound) Doxepin
Doxepin {u} (Compound) downregulates {v} (Gene) SDC1
SDC1 {u} (Gene) is downregulated by {v} (Compound) Flumazenil
Desipramine {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} (Compound) causes {v} (Side Effect) Aggression
Aggression {u} (Side Effect) is caused by {v} (Compound) Flumazenil
Desipramine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) regulates {v} (Gene) SERPINA3
SERPINA3 {u} (Gene) is upregulated by {v} (Compound) Flumazenil
Desipramine {u} (Compound) resembles {v} (Compound) Protriptyline
Protriptyline {u} (Compound) causes {v} (Side Effect) Ill-defined disorder
Ill-defined disorder {u} (Side Effect) is caused by {v} (Compound) Flumazenil
Desipramine (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Flumazenil (Compound)
Desipramine (Compound) resembles Doxepin (Compound) and Doxepin may lead to a major life threatening interaction when taken with Flumazenil
Desipramine (Compound) resembles Clomipramine (Compound) and Clomipramine may lead to a major life threatening interaction when taken with Flumazenil
Desipramine (Compound) resembles Protriptyline (Compound) and Protriptyline may lead to a major life threatening interaction when taken with Flumazenil
Desipramine (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Zolpidem (Compound) and Zolpidem may cause a minor interaction that can limit clinical effects when taken with Flumazenil
Desipramine (Compound) causes Ventricular extrasystoles (Side Effect) and Ventricular extrasystoles (Side Effect) is caused by Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Flumazenil
Desipramine (Compound) resembles Doxepin (Compound) and Doxepin (Compound) downregulates SDC1 (Gene) and SDC1 (Gene) is downregulated by Flumazenil (Compound)
Desipramine (Compound) resembles Maprotiline (Compound) and Maprotiline (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Flumazenil (Compound)
Desipramine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) regulates SERPINA3 (Gene) and SERPINA3 (Gene) is upregulated by Flumazenil (Compound)
Desipramine (Compound) resembles Protriptyline (Compound) and Protriptyline (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Flumazenil (Compound)