DDInter1548 DDInter1180
Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 1930s with the early use of [physostigmine] and [neostigmine]. By inhibiting the breakdown of acetylcholine in the neuromuscular junction, they increase signalling and relieve symptoms.[A231004, L32408, L32413] Pyridostigmine is the current drug of choice, with superior pharmacokinetics and reduced side effects compared to [neostigmine].[L32408, L32413] In addition to treating myasthenia gravis, pyridostigmine is used to reverse neuromuscular blocks
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Pyridostigmine {u} (Compound) resembles {v} (Compound) Neostigmine
Pyridostigmine {u} (Compound) binds {v} (Gene) BCHE
Pyridostigmine {u} (Compound) upregulates {v} (Gene) INPP4B
Pyridostigmine {u} (Compound) causes {v} (Side Effect) Cholinergic syndrome
Pyridostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fingolimod
Pyridostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Pyridostigmine (Compound) resembles Neostigmine (Compound)
Pyridostigmine (Compound) binds BCHE (Gene)
Pyridostigmine (Compound) upregulates INPP4B (Gene)
Pyridostigmine (Compound) causes Cholinergic syndrome (Side Effect)
Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone