DDInter1510 DDInter119
Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat a child) makes it an integral to WHO's plan to eliminate schistosomiasis by 2030.[A263206,A263211] Despite being approved since 1980, the exact mechanism of action is yet to be elucidated.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Praziquantel {u} (Compound) resembles {v} (Compound) Palonosetron
Praziquantel {u} (Compound) binds {v} (Gene) CYP3A5
Praziquantel {u} (Compound) upregulates {v} (Gene) PAK6
Praziquantel {u} (Compound) downregulates {v} (Gene) ATP6V1D
Praziquantel {u} (Compound) causes {v} (Side Effect) Decreased appetite
Praziquantel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Praziquantel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Isavuconazonium
Praziquantel {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Secobarbital
Praziquantel {u} may lead to a major life threatening interaction when taken with {v} Lumacaftor
Praziquantel {u} may lead to a major life threatening interaction when taken with {v} Rifabutin
Praziquantel (Compound) resembles Palonosetron (Compound)
Praziquantel (Compound) binds CYP3A5 (Gene)
Praziquantel (Compound) upregulates PAK6 (Gene)
Praziquantel (Compound) downregulates ATP6V1D (Gene)
Praziquantel (Compound) causes Decreased appetite (Side Effect)
Praziquantel may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Praziquantel may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital
Praziquantel may lead to a major life threatening interaction when taken with Lumacaftor
Praziquantel may lead to a major life threatening interaction when taken with Rifabutin