DDInter1639 DDInter1304
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina. Nitroglycerin causes vasodilation in both arteries and veins. Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure, and chronic anal fissure. It is also used to induce intraoperative hypotension.
Sapropterin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Nitroglycerin
Sapropterin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Atropine
Atropine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Sapropterin {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Scopolamine
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) interacts with {v} (Gene) GUCY1B3
GUCY1B3 {u} (Gene) is bound by {v} (Compound) Nitroglycerin
Sapropterin {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitroglycerin
Sapropterin {u} (Compound) causes {v} (Side Effect) Pharyngitis
Pharyngitis {u} (Side Effect) is caused by {v} (Compound) Dapsone
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitroglycerin
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Sapropterin {u} (Compound) binds {v} (Gene) NOS3
NOS3 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is palliated by {v} (Compound) Nitroglycerin
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitroglycerin
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Sapropterin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Nitroglycerin (Compound)
Sapropterin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Atropine (Compound) and Atropine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Sapropterin (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Scopolamine (Compound) and Scopolamine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) interacts with GUCY1B3 (Gene) and GUCY1B3 (Gene) is bound by Nitroglycerin (Compound)
Sapropterin (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Nitroglycerin
Sapropterin (Compound) causes Pharyngitis (Side Effect) and Pharyngitis (Side Effect) is caused by Dapsone (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Nitroglycerin
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Sapropterin (Compound) binds NOS3 (Gene) and NOS3 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is palliated by Nitroglycerin (Compound)
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Nitroglycerin
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) is downregulated by Mepenzolate (Compound) and Mepenzolate may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin