DDInter1460 DDInter1676
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.[A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects.[A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Phenytoin {u} (Compound) resembles {v} (Compound) Benzyl Benzoate
Phenytoin {u} (Compound) resembles {v} (Compound) Modafinil
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Phenytoin {u} (Compound) treats {v} (Disease) epilepsy syndrome
Phenytoin {u} (Compound) binds {v} (Gene) SLCO1C1
Phenytoin {u} (Compound) upregulates {v} (Gene) IL1R2
Phenytoin {u} (Compound) is included by {v} (Pharmacologic Class) Cytochrome P450 2C19 Inducers
Phenytoin {u} (Compound) downregulates {v} (Gene) CAST
Phenytoin {u} (Compound) causes {v} (Side Effect) Hodgkin's disease lymphocyte depletion type stage unspecified
Phenytoin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Phenytoin (Compound) resembles Benzyl Benzoate (Compound)
Phenytoin (Compound) resembles Modafinil (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Phenytoin (Compound) treats epilepsy syndrome (Disease)
Phenytoin (Compound) binds SLCO1C1 (Gene)
Phenytoin (Compound) upregulates IL1R2 (Gene)
Phenytoin (Compound) is included by Cytochrome P450 2C19 Inducers (Pharmacologic Class)
Phenytoin (Compound) downregulates CAST (Gene)
Phenytoin (Compound) causes Hodgkin's disease lymphocyte depletion type stage unspecified (Side Effect)
Phenytoin may cause a minor interaction that can limit clinical effects when taken with Bexarotene