DDInter1425 DDInter255
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Pentostatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Busulfan
Pentostatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Pentostatin {u} (Compound) resembles {v} (Compound) Trifluridine
Trifluridine {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) resembles {v} (Compound) Decitabine
Decitabine {u} (Compound) binds {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) resembles {v} (Compound) Trifluridine
Trifluridine {u} (Compound) downregulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) resembles {v} (Compound) Azacitidine
Azacitidine {u} (Compound) upregulates {v} (Gene) FOXJ3
FOXJ3 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) resembles {v} (Compound) Decitabine
Decitabine {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pentostatin {u} (Compound) resembles {v} (Compound) Adenosine
Adenosine {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Pentostatin (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Busulfan (Compound)
Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Pentostatin (Compound) resembles Trifluridine (Compound) and Trifluridine (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Busulfan (Compound)
Pentostatin (Compound) resembles Decitabine (Compound) and Decitabine (Compound) binds DCK (Gene) and DCK (Gene) is downregulated by Busulfan (Compound)
Pentostatin (Compound) resembles Trifluridine (Compound) and Trifluridine (Compound) downregulates PSRC1 (Gene) and PSRC1 (Gene) is upregulated by Busulfan (Compound)
Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)
Pentostatin (Compound) resembles Azacitidine (Compound) and Azacitidine (Compound) upregulates FOXJ3 (Gene) and FOXJ3 (Gene) is downregulated by Busulfan (Compound)
Pentostatin (Compound) resembles Decitabine (Compound) and Decitabine (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is downregulated by Busulfan (Compound)
Pentostatin (Compound) resembles Adenosine (Compound) and Adenosine (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is downregulated by Busulfan (Compound)