DDInter1156 DDInter1376
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Mercaptopurine {u} (Compound) resembles {v} (Compound) Adenine
Mercaptopurine {u} (Compound) treats {v} (Disease) Crohn's disease
Mercaptopurine {u} (Compound) binds {v} (Gene) AOX1
Mercaptopurine {u} (Compound) causes {v} (Side Effect) Candida infection
Mercaptopurine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Mercaptopurine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cannabidiol
Mercaptopurine {u} may lead to a major life threatening interaction when taken with {v} Certolizumab pegol
Mercaptopurine {u} may lead to a major life threatening interaction when taken with {v} Natalizumab
Mercaptopurine (Compound) resembles Adenine (Compound)
Mercaptopurine (Compound) treats Crohn's disease (Disease)
Mercaptopurine (Compound) binds AOX1 (Gene)
Mercaptopurine (Compound) causes Candida infection (Side Effect)
Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Mercaptopurine may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol
Mercaptopurine may lead to a major life threatening interaction when taken with Certolizumab pegol
Mercaptopurine may lead to a major life threatening interaction when taken with Natalizumab