DDInter1678 DDInter556
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis. It was marketed in 1911.
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Dihydrocodeine
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Codeine
Codeine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Galantamine and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dihydrocodeine (Compound)
Sirolimus (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Dihydrocodeine (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Galantamine and Galantamine (Compound) resembles Hydrocodone (Compound) and Hydrocodone (Compound) resembles Dihydrocodeine (Compound)
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Sirolimus (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Sirolimus (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Oxymorphone (Compound) and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)
Sirolimus (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Galantamine and Galantamine (Compound) resembles Codeine (Compound) and Codeine (Compound) resembles Dihydrocodeine (Compound)
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Oxymorphone (Compound) and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)