DDInter1423 DDInter178
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Pentobarbital {u} (Compound) resembles {v} (Compound) Thiopental
Pentobarbital {u} (Compound) binds {v} (Gene) GABRA5
Pentobarbital {u} (Compound) upregulates {v} (Gene) BUB1B
Pentobarbital {u} (Compound) downregulates {v} (Gene) GSTZ1
Pentobarbital {u} (Compound) causes {v} (Side Effect) Dizziness
Pentobarbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Pentobarbital {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bortezomib
Pentobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetracosactide
Pentobarbital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Pentobarbital {u} may lead to a major life threatening interaction when taken with {v} Morphine
Pentobarbital (Compound) resembles Thiopental (Compound)
Pentobarbital (Compound) binds GABRA5 (Gene)
Pentobarbital (Compound) upregulates BUB1B (Gene)
Pentobarbital (Compound) downregulates GSTZ1 (Gene)
Pentobarbital (Compound) causes Dizziness (Side Effect)
Pentobarbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Pentobarbital may cause a minor interaction that can limit clinical effects when taken with Bortezomib
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Clemastine
Pentobarbital may lead to a major life threatening interaction when taken with Morphine