DDInter537 DDInter119
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin]. The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Diclofenac {u} (Compound) resembles {v} (Compound) Clonidine
Diclofenac {u} (Compound) resembles {v} (Compound) Nepafenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Diclofenac {u} (Compound) binds {v} (Gene) ALOX5
Diclofenac {u} (Compound) palliates {v} (Disease) systemic scleroderma
Diclofenac {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Diclofenac {u} (Compound) downregulates {v} (Gene) PUF60
Diclofenac {u} (Compound) causes {v} (Side Effect) Corneal disorder
Diclofenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Colestipol
Diclofenac {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cholestyramine
Diclofenac (Compound) resembles Clonidine (Compound)
Diclofenac (Compound) resembles Nepafenac (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac
Diclofenac (Compound) binds ALOX5 (Gene)
Diclofenac (Compound) palliates systemic scleroderma (Disease)
Diclofenac (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Diclofenac (Compound) downregulates PUF60 (Gene)
Diclofenac (Compound) causes Corneal disorder (Side Effect)
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Colestipol
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Cholestyramine