DDInter1489 DDInter698
Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line.
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Polymyxin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Polymyxin B {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Polymyxin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Polymyxin B {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Polymyxin B {u} (Compound) resembles {v} (Compound) Octreotide
Octreotide {u} (Compound) causes {v} (Side Effect) Arthropathy
Arthropathy {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Polymyxin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Etidronic acid
Polymyxin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Polymyxin B {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Etidronic acid
Polymyxin B {u} (Compound) resembles {v} (Compound) Bacitracin
Bacitracin {u} (Compound) upregulates {v} (Gene) PLSCR1
PLSCR1 {u} (Gene) is upregulated by {v} (Compound) Etidronic acid
Polymyxin B {u} (Compound) resembles {v} (Compound) Terlipressin
Terlipressin {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate (Compound) resembles Etidronic acid (Compound)
Polymyxin B (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Etidronic acid (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Polymyxin B (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Risedronic acid (Compound) and Risedronic acid (Compound) resembles Etidronic acid (Compound)
Polymyxin B (Compound) resembles Octreotide (Compound) and Octreotide (Compound) causes Arthropathy (Side Effect) and Arthropathy (Side Effect) is caused by Etidronic acid (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate (Compound) resembles Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Etidronic acid (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid and Pamidronic acid (Compound) resembles Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Polymyxin B (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Clodronate (Compound) and Clodronate (Compound) resembles Etidronic acid (Compound)
Polymyxin B (Compound) resembles Bacitracin (Compound) and Bacitracin (Compound) upregulates PLSCR1 (Gene) and PLSCR1 (Gene) is upregulated by Etidronic acid (Compound)
Polymyxin B (Compound) resembles Terlipressin (Compound) and Terlipressin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Etidronic acid (Compound)