DDInter458 DDInter1534
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Propafenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Propafenone
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Propafenone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Propafenone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Carvedilol
Carvedilol {u} (Compound) resembles {v} (Compound) Propafenone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Propafenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propafenone
Cyclosporine {u} (Compound) downregulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Granisetron
Granisetron {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propafenone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Propafenone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Hepatic function abnormal {u} (Side Effect) is caused by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} (Compound) resembles {v} (Compound) Propafenone
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Propafenone (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Propafenone (Compound)
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Propafenone (Compound)
Cyclosporine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Propafenone (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carvedilol (Compound) and Carvedilol (Compound) resembles Propafenone (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Atomoxetine (Compound) and Atomoxetine (Compound) resembles Propafenone (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Propafenone
Cyclosporine (Compound) downregulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Granisetron (Compound) and Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Propafenone
Cyclosporine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Fentanyl (Compound) and Fentanyl (Compound) resembles Propafenone (Compound)
Cyclosporine (Compound) causes Hepatic function abnormal (Side Effect) and Hepatic function abnormal (Side Effect) is caused by Dextropropoxyphene (Compound) and Dextropropoxyphene (Compound) resembles Propafenone (Compound)