DDInter1397 DDInter645
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Paroxetine {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Enoxaparin
Paroxetine {u} (Compound) causes {v} (Side Effect) Oedema peripheral
Oedema peripheral {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Paroxetine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is regulated by {v} (Gene) SERPINC1
SERPINC1 {u} (Gene) is bound by {v} (Compound) Enoxaparin
Paroxetine {u} (Compound) downregulates {v} (Gene) TATDN2
TATDN2 {u} (Gene) is regulated by {v} (Gene) SERPINC1
SERPINC1 {u} (Gene) is bound by {v} (Compound) Enoxaparin
Paroxetine {u} (Compound) causes {v} (Side Effect) Vesiculobullous rash
Vesiculobullous rash {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Paroxetine {u} (Compound) causes {v} (Side Effect) Thrombosis
Thrombosis {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Paroxetine {u} (Compound) downregulates {v} (Gene) NME1
NME1 {u} (Gene) is downregulated by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Paroxetine {u} (Compound) upregulates {v} (Gene) FDPS
FDPS {u} (Gene) is upregulated by {v} (Compound) Sunitinib
Sunitinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Enoxaparin
Paroxetine {u} (Compound) downregulates {v} (Gene) NME1
NME1 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Treprostinil {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Paroxetine {u} (Compound) upregulates {v} (Gene) FDPS
FDPS {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Omacetaxine mepesuccinate {u} may lead to a major life threatening interaction when taken with {v} Enoxaparin
Paroxetine (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Enoxaparin (Compound)
Paroxetine (Compound) causes Oedema peripheral (Side Effect) and Oedema peripheral (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Paroxetine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is regulated by SERPINC1 (Gene) and SERPINC1 (Gene) is bound by Enoxaparin (Compound)
Paroxetine (Compound) downregulates TATDN2 (Gene) and TATDN2 (Gene) is regulated by SERPINC1 (Gene) and SERPINC1 (Gene) is bound by Enoxaparin (Compound)
Paroxetine (Compound) causes Vesiculobullous rash (Side Effect) and Vesiculobullous rash (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may lead to a major life threatening interaction when taken with Enoxaparin
Paroxetine (Compound) causes Thrombosis (Side Effect) and Thrombosis (Side Effect) is caused by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Paroxetine (Compound) downregulates NME1 (Gene) and NME1 (Gene) is downregulated by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Enoxaparin
Paroxetine (Compound) upregulates FDPS (Gene) and FDPS (Gene) is upregulated by Sunitinib (Compound) and Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Paroxetine (Compound) downregulates NME1 (Gene) and NME1 (Gene) is downregulated by Treprostinil (Compound) and Treprostinil may lead to a major life threatening interaction when taken with Enoxaparin
Paroxetine (Compound) upregulates FDPS (Gene) and FDPS (Gene) is downregulated by Omacetaxine mepesuccinate (Compound) and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Enoxaparin