DDInter781 DDInter856
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Fosinopril {u} (Compound) resembles {v} (Compound) Enalapril
Fosinopril {u} (Compound) resembles {v} (Compound) Spirapril
Fosinopril {u} (Compound) treats {v} (Disease) hypertension
Fosinopril {u} (Compound) binds {v} (Gene) SLC15A1
Fosinopril {u} (Compound) upregulates {v} (Gene) SYNGR3
Fosinopril {u} (Compound) causes {v} (Side Effect) Urticaria
Fosinopril (Compound) resembles Enalapril (Compound)
Fosinopril (Compound) resembles Spirapril (Compound)
Fosinopril (Compound) treats hypertension (Disease)
Fosinopril (Compound) binds SLC15A1 (Gene)
Fosinopril (Compound) upregulates SYNGR3 (Gene)
Fosinopril (Compound) causes Urticaria (Side Effect)