DDInter458 DDInter1287
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is downregulated by {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nervousness
Nervousness {u} (Side Effect) is caused by {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Clevidipine
Clevidipine {u} (Compound) resembles {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Felodipine
Felodipine {u} (Compound) resembles {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Nifedipine
Nifedipine {u} (Compound) resembles {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Nisoldipine
Nisoldipine {u} (Compound) resembles {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nervousness
Nervousness {u} (Side Effect) is caused by {v} (Compound) Felodipine
Felodipine {u} (Compound) resembles {v} (Compound) Nicardipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nicardipine
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Nicardipine (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Nicardipine (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is downregulated by Nicardipine (Compound)
Cyclosporine (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Nicardipine (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clevidipine (Compound) and Clevidipine (Compound) resembles Nicardipine (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Felodipine (Compound) and Felodipine (Compound) resembles Nicardipine (Compound)
Cyclosporine (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Nifedipine (Compound) and Nifedipine (Compound) resembles Nicardipine (Compound)
Cyclosporine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Nisoldipine (Compound) and Nisoldipine (Compound) resembles Nicardipine (Compound)
Cyclosporine (Compound) causes Nervousness (Side Effect) and Nervousness (Side Effect) is caused by Felodipine (Compound) and Felodipine (Compound) resembles Nicardipine (Compound)
Cyclosporine (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine