DDInter604 DDInter869
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thrombo
C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and treatment of Hereditary Angioedema (HAE), a human genetic disorder caused by a shortage of C1 inhibitor activity that results in an overreaction of the immune system. The disease is characterized by acute attacks of painful, and in some cases, fatal swelling of several soft tissues or edema, which may last up to five days when untreated.[L16586, L16606]
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} (Compound) resembles {v} (Compound) Danazol
Danazol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Testolactone
Testolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Testolactone
Testolactone {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Carfilzomib {u} may lead to a major life threatening interaction when taken with {v} Human C1-esterase inhibitor
Drospirenone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Human C1-esterase inhibitor
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) resembles Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Testolactone (Compound) and Testolactone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Testosterone (Compound) and Testosterone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Testolactone (Compound) and Testolactone may lead to a major life threatening interaction when taken with Carfilzomib and Carfilzomib may lead to a major life threatening interaction when taken with Human C1-esterase inhibitor
Drospirenone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor