DDInter458 DDInter542
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is bound by {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is regulated by {v} (Gene) GPR35
GPR35 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is downregulated by {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Cyclosporine {u} (Compound) upregulates {v} (Gene) TRAK2
TRAK2 {u} (Gene) is regulated by {v} (Gene) GPR35
GPR35 {u} (Gene) is bound by {v} (Compound) Dicoumarol
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dicoumarol (Compound)
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is bound by Dicoumarol (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Dicoumarol (Compound)
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is regulated by GPR35 (Gene) and GPR35 (Gene) is bound by Dicoumarol (Compound)
Cyclosporine (Compound) downregulates CRYZ (Gene) and CRYZ (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is downregulated by Dicoumarol (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Cyclosporine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Dicoumarol (Compound)
Cyclosporine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with NQO1 (Gene) and NQO1 (Gene) is bound by Dicoumarol (Compound)
Cyclosporine (Compound) upregulates TRAK2 (Gene) and TRAK2 (Gene) is regulated by GPR35 (Gene) and GPR35 (Gene) is bound by Dicoumarol (Compound)