DDInter154 DDInter1470
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Azelastine {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Pimozide
Azelastine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is downregulated by {v} (Compound) Pimozide
Azelastine {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Pimozide
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pimozide
Azelastine {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Pimozide
Azelastine {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Domperidone
Domperidone {u} (Compound) resembles {v} (Compound) Pimozide
Azelastine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Ticlopidine
Ticlopidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pimozide
Azelastine {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Pimozide
Azelastine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Fluspirilene
Fluspirilene {u} (Compound) resembles {v} (Compound) Pimozide
Azelastine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) regulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Azelastine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Pimozide (Compound)
Azelastine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregulated by Pimozide (Compound)
Azelastine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pimozide (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Azelastine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Pimozide (Compound)
Azelastine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Domperidone (Compound) and Domperidone (Compound) resembles Pimozide (Compound)
Azelastine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Ticlopidine (Compound) and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Pimozide
Azelastine (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Pimozide (Compound)
Azelastine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Fluspirilene (Compound) and Fluspirilene (Compound) resembles Pimozide (Compound)
Azelastine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) regulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Pimozide (Compound)