DDInter600 DDInter1747
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Doxylamine {u} (Compound) resembles {v} (Compound) Toremifene
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Doxylamine {u} (Compound) resembles {v} (Compound) Chloropyramine
Doxylamine {u} (Compound) binds {v} (Gene) HRH1
Doxylamine {u} (Compound) upregulates {v} (Gene) KIT
Doxylamine {u} (Compound) downregulates {v} (Gene) IGFBP2
Doxylamine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Doxylamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clozapine
Doxylamine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Doxylamine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Disopyramide
Doxylamine (Compound) resembles Toremifene (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Doxylamine (Compound) resembles Chloropyramine (Compound)
Doxylamine (Compound) binds HRH1 (Gene)
Doxylamine (Compound) upregulates KIT (Gene)
Doxylamine (Compound) downregulates IGFBP2 (Gene)
Doxylamine (Compound) causes Decreased appetite (Side Effect)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Clozapine
Doxylamine may lead to a major life threatening interaction when taken with Zonisamide
Doxylamine (Compound) resembles Disopyramide (Compound) and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide