DDInter542 DDInter1335
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may lead to a major life threatening interaction when taken with {v} Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) is regulated by {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may lead to a major life threatening interaction when taken with {v} Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} (Compound) upregulates {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) regulates {v} (Gene) SYNGR3
SYNGR3 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) interacts with {v} (Gene) TMEM230
TMEM230 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) interacts with {v} (Gene) STAMBP
STAMBP {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) is regulated by DDX42 (Gene) and DDX42 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Warfarin (Compound) and Warfarin may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin (Compound) upregulates CDK6 (Gene) and CDK6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) regulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) interacts with TMEM230 (Gene) and TMEM230 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) interacts with STAMBP (Gene) and STAMBP (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)