DDInter1164 DDInter336
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. Another well-known benefit of this drug is modest weight loss, making it an effective choice for obese patients type II diabetes. Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the US in 1995.
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Metformin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Celecoxib
Metformin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) resembles {v} (Compound) Celecoxib
Metformin {u} (Compound) treats {v} (Disease) type 2 diabetes mellitus
type 2 diabetes mellitus {u} (Disease) is associated with {v} (Gene) ZMIZ1
ZMIZ1 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Metformin {u} (Compound) treats {v} (Disease) metabolic syndrome X
metabolic syndrome X {u} (Disease) is associated with {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Metformin {u} (Compound) binds {v} (Gene) NDUFA6
NDUFA6 {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Celecoxib
Metformin {u} (Compound) binds {v} (Gene) NDUFS1
NDUFS1 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Celecoxib
Metformin {u} (Compound) binds {v} (Gene) NDUFA2
NDUFA2 {u} (Gene) is upregulated by {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Metformin {u} (Compound) binds {v} (Gene) NDUFAF4
NDUFAF4 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Celecoxib
Metformin {u} (Compound) binds {v} (Gene) NDUFC1
NDUFC1 {u} (Gene) is downregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is palliated by {v} (Compound) Celecoxib
Metformin {u} (Compound) binds {v} (Gene) NDUFA9
NDUFA9 {u} (Gene) is regulated by {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Celecoxib
Metformin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Celecoxib (Compound)
Metformin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etoricoxib (Compound) and Etoricoxib (Compound) resembles Celecoxib (Compound)
Metformin (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is associated with ZMIZ1 (Gene) and ZMIZ1 (Gene) is downregulated by Celecoxib (Compound)
Metformin (Compound) treats metabolic syndrome X (Disease) and metabolic syndrome X (Disease) is associated with PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Metformin (Compound) binds NDUFA6 (Gene) and NDUFA6 (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Celecoxib (Compound)
Metformin (Compound) binds NDUFS1 (Gene) and NDUFS1 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Celecoxib (Compound)
Metformin (Compound) binds NDUFA2 (Gene) and NDUFA2 (Gene) is upregulated by hematologic cancer (Disease) and hematologic cancer (Disease) is palliated by Celecoxib (Compound)
Metformin (Compound) binds NDUFAF4 (Gene) and NDUFAF4 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Celecoxib (Compound)
Metformin (Compound) binds NDUFC1 (Gene) and NDUFC1 (Gene) is downregulated by colon cancer (Disease) and colon cancer (Disease) is palliated by Celecoxib (Compound)
Metformin (Compound) binds NDUFA9 (Gene) and NDUFA9 (Gene) is regulated by ALB (Gene) and ALB (Gene) is bound by Celecoxib (Compound)