DDInter1607 DDInter527
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dihydrocodeine
Dihydrocodeine {u} (Compound) resembles {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) interacts with {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Memantine
Memantine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dextromethorphan
Ritonavir {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) PGRMC1
PGRMC1 {u} (Gene) is bound by {v} (Compound) Dextromethorphan
Ritonavir {u} (Compound) upregulates {v} (Gene) AGR2
AGR2 {u} (Gene) is upregulated by {v} (Compound) Trifluoperazine
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextromethorphan
Ritonavir {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Gastrointestinal pain {u} (Side Effect) is caused by {v} (Compound) Levorphanol
Levorphanol {u} (Compound) resembles {v} (Compound) Dextromethorphan
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Ritonavir (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Dextromethorphan (Compound)
Ritonavir (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Dextromethorphan (Compound)
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dihydrocodeine (Compound) and Dihydrocodeine (Compound) resembles Dextromethorphan (Compound)
Ritonavir (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) interacts with PGRMC1 (Gene) and PGRMC1 (Gene) is bound by Dextromethorphan (Compound)
Ritonavir (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Memantine (Compound) and Memantine may cause a minor interaction that can limit clinical effects when taken with Dextromethorphan
Ritonavir (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Dextromethorphan (Compound)
Ritonavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates PGRMC1 (Gene) and PGRMC1 (Gene) is bound by Dextromethorphan (Compound)
Ritonavir (Compound) upregulates AGR2 (Gene) and AGR2 (Gene) is upregulated by Trifluoperazine (Compound) and Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan
Ritonavir (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Levorphanol (Compound) and Levorphanol (Compound) resembles Dextromethorphan (Compound)