DDInter458 DDInter973
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is bound by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) upregulates {v} (Gene) WDR45
WDR45 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCND3
CCND3 {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) binds {v} (Gene) PPIF
PPIF {u} (Gene) is upregulated by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) downregulates {v} (Gene) KIF14
KIF14 {u} (Gene) is downregulated by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) upregulates {v} (Gene) ST7
ST7 {u} (Gene) is downregulated by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Visual impairment
Visual impairment {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC1
ABCC1 {u} (Gene) is upregulated by {v} (Disease) colon cancer
colon cancer {u} (Disease) is treated by {v} (Compound) Irinotecan
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Topotecan
Topotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Irinotecan
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Norfloxacin
Norfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Irinotecan
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Irinotecan (Compound)
Cyclosporine (Compound) upregulates WDR45 (Gene) and WDR45 (Gene) is upregulated by Irinotecan (Compound)
Cyclosporine (Compound) downregulates CCND3 (Gene) and CCND3 (Gene) is upregulated by Irinotecan (Compound)
Cyclosporine (Compound) binds PPIF (Gene) and PPIF (Gene) is upregulated by Irinotecan (Compound)
Cyclosporine (Compound) downregulates KIF14 (Gene) and KIF14 (Gene) is downregulated by Irinotecan (Compound)
Cyclosporine (Compound) upregulates ST7 (Gene) and ST7 (Gene) is downregulated by Irinotecan (Compound)
Cyclosporine (Compound) causes Visual impairment (Side Effect) and Visual impairment (Side Effect) is caused by Irinotecan (Compound)
Cyclosporine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is upregulated by colon cancer (Disease) and colon cancer (Disease) is treated by Irinotecan (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Topotecan (Compound) and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Cyclosporine (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Norfloxacin (Compound) and Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Irinotecan