DDInter1570 DDInter32
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.
Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations as detected by an FDA-approved test . Gilotrif (afatinib) is the first FDA-approved oncology product from Boehringer Ingelheim .
Ranolazine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Afatinib
Ranolazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Afatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Connective tissue disorder
Connective tissue disorder {u} (Side Effect) is caused by {v} (Compound) Afatinib
Ranolazine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is upregulated by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Afatinib
Ranolazine {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Afatinib
Ranolazine {u} (Compound) downregulates {v} (Gene) SDHB
SDHB {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Afatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Connective tissue disorder
Connective tissue disorder {u} (Side Effect) is caused by {v} (Compound) Bedaquiline
Bedaquiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Afatinib
Ranolazine {u} (Compound) causes {v} (Side Effect) Malnutrition
Malnutrition {u} (Side Effect) is caused by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Afatinib
Ranolazine {u} (Compound) resembles {v} (Compound) Guaifenesin
Guaifenesin {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Afatinib
Ranolazine {u} (Compound) upregulates {v} (Gene) HIST2H2BE
HIST2H2BE {u} (Gene) is regulated by {v} (Gene) EGFR
EGFR {u} (Gene) is bound by {v} (Compound) Afatinib
Ranolazine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Afatinib (Compound)
Ranolazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Afatinib (Compound)
Ranolazine (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Afatinib (Compound)
Ranolazine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is upregulated by Gefitinib (Compound) and Gefitinib (Compound) resembles Afatinib (Compound)
Ranolazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Gefitinib (Compound) and Gefitinib (Compound) resembles Afatinib (Compound)
Ranolazine (Compound) downregulates SDHB (Gene) and SDHB (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Afatinib (Compound)
Ranolazine (Compound) causes Connective tissue disorder (Side Effect) and Connective tissue disorder (Side Effect) is caused by Bedaquiline (Compound) and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Afatinib
Ranolazine (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Gefitinib (Compound) and Gefitinib (Compound) resembles Afatinib (Compound)
Ranolazine (Compound) resembles Guaifenesin (Compound) and Guaifenesin (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Afatinib (Compound)
Ranolazine (Compound) upregulates HIST2H2BE (Gene) and HIST2H2BE (Gene) is regulated by EGFR (Gene) and EGFR (Gene) is bound by Afatinib (Compound)