DDInter1662 DDInter120
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may lead to a major life threatening interaction when taken with {v} Arsenic trioxide
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Arsenic trioxide
Sertraline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TXNRD1
TXNRD1 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) interacts with {v} (Gene) JUN
JUN {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Loperamide
Loperamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arsenic trioxide
Sertraline {u} (Compound) downregulates {v} (Gene) CSRP1
CSRP1 {u} (Gene) is regulated by {v} (Gene) JUN
JUN {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) regulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Arsenic trioxide
Sertraline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Arsenic trioxide (Compound)
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may lead to a major life threatening interaction when taken with Arsenic trioxide
Sertraline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Sertraline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TXNRD1 (Gene) and TXNRD1 (Gene) is bound by Arsenic trioxide (Compound)
Sertraline (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) interacts with JUN (Gene) and JUN (Gene) is bound by Arsenic trioxide (Compound)
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is bound by Arsenic trioxide (Compound)
Sertraline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Loperamide (Compound) and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Sertraline (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is regulated by JUN (Gene) and JUN (Gene) is bound by Arsenic trioxide (Compound)
Sertraline (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) regulates IKBKB (Gene) and IKBKB (Gene) is bound by Arsenic trioxide (Compound)
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Arsenic trioxide (Compound)