DDInter747 DDInter1376
Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position of the steroid structure - this fluorination is thought to be crucial to fludrocortisone's significant mineralocorticoid potency.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Fludrocortisone {u} (Compound) resembles {v} (Compound) Dexamethasone
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Testosterone
Fludrocortisone {u} (Compound) binds {v} (Gene) NR3C1
Fludrocortisone {u} (Compound) palliates {v} (Disease) Parkinson's disease
Fludrocortisone {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Aluminum hydroxide
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticlopidine
Fludrocortisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bisacodyl
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Certolizumab pegol
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Moxifloxacin
Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Testosterone
Fludrocortisone (Compound) binds NR3C1 (Gene)
Fludrocortisone (Compound) palliates Parkinson's disease (Disease)
Fludrocortisone (Compound) causes Hyperglycaemia (Side Effect)
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Ticlopidine
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Fludrocortisone may lead to a major life threatening interaction when taken with Certolizumab pegol
Fludrocortisone may lead to a major life threatening interaction when taken with Moxifloxacin