DDInter1494 DDInter1376
Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Posaconazole {u} (Compound) resembles {v} (Compound) Itraconazole
Posaconazole {u} (Compound) binds {v} (Gene) ABCB1
Posaconazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Posaconazole {u} (Compound) causes {v} (Side Effect) Kidney function abnormal
Posaconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Magnesium hydroxide
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tioguanine
Posaconazole {u} may lead to a major life threatening interaction when taken with {v} Panobinostat
Posaconazole {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Posaconazole (Compound) resembles Itraconazole (Compound)
Posaconazole (Compound) binds ABCB1 (Gene)
Posaconazole (Compound) is included by Azoles (Pharmacologic Class)
Posaconazole (Compound) causes Kidney function abnormal (Side Effect)
Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine
Posaconazole may lead to a major life threatening interaction when taken with Panobinostat
Posaconazole may lead to a major life threatening interaction when taken with Leflunomide