DDInter694 DDInter576
A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Ethionamide {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is regulated by {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) upregulates {v} (Gene) ZNF586
ZNF586 {u} (Gene) is regulated by {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) upregulates {v} (Gene) NUDT9
NUDT9 {u} (Gene) regulates {v} (Gene) ICMT
ICMT {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) upregulates {v} (Gene) ZNF586
ZNF586 {u} (Gene) is regulated by {v} (Gene) IGF2BP2
IGF2BP2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) upregulates {v} (Gene) IKZF1
IKZF1 {u} (Gene) interacts with {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) upregulates {v} (Gene) CTNNAL1
CTNNAL1 {u} (Gene) interacts with {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) upregulates {v} (Gene) ZNF586
ZNF586 {u} (Gene) regulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Ethionamide {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is regulated by {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Ethionamide (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Disulfiram (Compound)
Ethionamide (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Disulfiram (Compound)
Ethionamide (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is regulated by DNAJB2 (Gene) and DNAJB2 (Gene) is upregulated by Disulfiram (Compound)
Ethionamide (Compound) upregulates ZNF586 (Gene) and ZNF586 (Gene) is regulated by DDB2 (Gene) and DDB2 (Gene) is downregulated by Disulfiram (Compound)
Ethionamide (Compound) upregulates NUDT9 (Gene) and NUDT9 (Gene) regulates ICMT (Gene) and ICMT (Gene) is downregulated by Disulfiram (Compound)
Ethionamide (Compound) upregulates ZNF586 (Gene) and ZNF586 (Gene) is regulated by IGF2BP2 (Gene) and IGF2BP2 (Gene) is upregulated by Disulfiram (Compound)
Ethionamide (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) interacts with HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Disulfiram (Compound)
Ethionamide (Compound) upregulates CTNNAL1 (Gene) and CTNNAL1 (Gene) interacts with CEBPD (Gene) and CEBPD (Gene) is upregulated by Disulfiram (Compound)
Ethionamide (Compound) upregulates ZNF586 (Gene) and ZNF586 (Gene) regulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Disulfiram (Compound)
Ethionamide (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is regulated by CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)