DDInter1061 DDInter1233
Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available. In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogen
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Levonorgestrel {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) downregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) downregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) regulates {v} (Gene) PEG10
PEG10 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) downregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is regulated by {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is upregulated by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) upregulates {v} (Gene) USP6NL
USP6NL {u} (Gene) is upregulated by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Levonorgestrel {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is regulated by {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Levonorgestrel (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Mitotane (Compound)
Levonorgestrel (Compound) downregulates ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Mitotane (Compound)
Levonorgestrel (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Mitotane (Compound)
Levonorgestrel (Compound) downregulates ADGRE5 (Gene) and ADGRE5 (Gene) regulates PEG10 (Gene) and PEG10 (Gene) is downregulated by Mitotane (Compound)
Levonorgestrel (Compound) downregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is regulated by FAM69A (Gene) and FAM69A (Gene) is downregulated by Mitotane (Compound)
Levonorgestrel (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Levonorgestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Levonorgestrel (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is upregulated by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Levonorgestrel (Compound) upregulates USP6NL (Gene) and USP6NL (Gene) is upregulated by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Levonorgestrel (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is regulated by EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Mitotane (Compound)