DDInter1619 DDInter1879
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Triprolidine
Ropinirole {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Triprolidine
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Ropinirole {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) downregulates {v} (Gene) TXNDC9
TXNDC9 {u} (Gene) is downregulated by {v} (Compound) Triprolidine
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Triprolidine
Ropinirole {u} (Compound) palliates {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is treated by {v} (Compound) Donepezil
Donepezil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Ropinirole {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Pergolide
Pergolide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Triprolidine
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) regulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Triprolidine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triprolidine
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Ropinirole (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Ropinirole (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Triprolidine (Compound)
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Triprolidine (Compound)
Ropinirole (Compound) palliates Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is treated by Donepezil (Compound) and Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Ropinirole (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Pergolide (Compound) and Pergolide may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Triprolidine (Compound)
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) regulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Triprolidine (Compound)
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Cyproheptadine (Compound) and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine