DDInter644 DDInter255
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Enoxacin {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is regulated by {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Enoxacin {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Levofloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) downregulates {v} (Gene) RNF167
RNF167 {u} (Gene) is regulated by {v} (Gene) FGFR4
FGFR4 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Enoxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) interacts with {v} (Gene) PARP1
PARP1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Enoxacin (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Busulfan (Compound)
Enoxacin (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Busulfan (Compound)
Enoxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Enoxacin (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is regulated by GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Enoxacin (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Enoxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Busulfan (Compound)
Enoxacin (Compound) resembles Levofloxacin (Compound) and Levofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Busulfan (Compound)
Enoxacin (Compound) downregulates DLD (Gene) and DLD (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Enoxacin (Compound) downregulates RNF167 (Gene) and RNF167 (Gene) is regulated by FGFR4 (Gene) and FGFR4 (Gene) is upregulated by Busulfan (Compound)
Enoxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) interacts with PARP1 (Gene) and PARP1 (Gene) is upregulated by Busulfan (Compound)