DDInter1662 DDInter899
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
Sertraline {u} (Compound) upregulates {v} (Gene) CYP51A1
Sertraline {u} (Compound) palliates {v} (Disease) schizophrenia
Sertraline {u} (Compound) downregulates {v} (Gene) MRPL19
Sertraline {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Sertraline (Compound) resembles Maprotiline (Compound)
Sertraline (Compound) binds CYP3A4 (Gene)
Sertraline (Compound) upregulates CYP51A1 (Gene)
Sertraline (Compound) palliates schizophrenia (Disease)
Sertraline (Compound) downregulates MRPL19 (Gene)
Sertraline (Compound) causes Anaphylactic shock (Side Effect)