DDInter1876 DDInter576
Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Trimipramine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) upregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is downregulated by {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) is regulated by {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Trimipramine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) regulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Trimipramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Trimipramine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Disulfiram (Compound)
Trimipramine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Trimipramine (Compound) upregulates SUV39H1 (Gene) and SUV39H1 (Gene) is downregulated by Disulfiram (Compound)
Trimipramine (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Disulfiram (Compound)
Trimipramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Trimipramine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is downregulated by alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Trimipramine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates CTSL (Gene) and CTSL (Gene) is upregulated by Disulfiram (Compound)
Trimipramine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is regulated by NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Trimipramine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) regulates NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)