DDInter150 DDInter1334
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase, subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene. Olsalazine is used in the treatment of ulcerative colitis.[L45023,L45151]
Azathioprine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Olsalazine
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) is bound by {v} (Compound) Olsalazine
Azathioprine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Mesalazine
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Azathioprine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Magnesium salicylate
Magnesium salicylate {u} (Compound) resembles {v} (Compound) Olsalazine
Azathioprine {u} (Compound) binds {v} (Gene) TPMT
TPMT {u} (Gene) is bound by {v} (Compound) Mercaptopurine
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Azathioprine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Diflunisal
Diflunisal {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Azathioprine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is associated with {v} (Gene) PTGS1
PTGS1 {u} (Gene) is bound by {v} (Compound) Olsalazine
Azathioprine {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Salsalate
Salsalate {u} (Compound) resembles {v} (Compound) Olsalazine
Azathioprine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is treated by {v} (Compound) Mercaptopurine
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Azathioprine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Gallium nitrate
Gallium nitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olsalazine
Azathioprine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Olsalazine (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) is bound by Olsalazine (Compound)
Azathioprine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Mesalazine (Compound) and Mesalazine (Compound) resembles Olsalazine (Compound)
Azathioprine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Magnesium salicylate (Compound) and Magnesium salicylate (Compound) resembles Olsalazine (Compound)
Azathioprine (Compound) binds TPMT (Gene) and TPMT (Gene) is bound by Mercaptopurine (Compound) and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Azathioprine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Diflunisal (Compound) and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Azathioprine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is associated with PTGS1 (Gene) and PTGS1 (Gene) is bound by Olsalazine (Compound)
Azathioprine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Salsalate (Compound) and Salsalate (Compound) resembles Olsalazine (Compound)
Azathioprine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is treated by Mercaptopurine (Compound) and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine
Azathioprine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Gallium nitrate (Compound) and Gallium nitrate may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine