DDInter1607 DDInter1394
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Paricalcitol
Ritonavir {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Paricalcitol
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paricalcitol
Ritonavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cholecalciferol
Cholecalciferol {u} may lead to a major life threatening interaction when taken with {v} Paricalcitol
Ritonavir {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Telithromycin
Telithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paricalcitol
Ritonavir {u} (Compound) causes {v} (Side Effect) Arthritis
Arthritis {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Paricalcitol
Ritonavir {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Calcitriol
Calcitriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Ritonavir {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Calcipotriol
Calcipotriol {u} (Compound) resembles {v} (Compound) Paricalcitol
Ritonavir {u} (Compound) resembles {v} (Compound) Carfilzomib
Carfilzomib {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Paricalcitol
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Paricalcitol
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paricalcitol (Compound)
Ritonavir (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Paricalcitol (Compound)
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol
Ritonavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cholecalciferol (Compound) and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalcitol
Ritonavir (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Telithromycin (Compound) and Telithromycin may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol
Ritonavir (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Indapamide (Compound) and Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol
Ritonavir (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Calcitriol (Compound) and Calcitriol (Compound) resembles Paricalcitol (Compound)
Ritonavir (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Calcipotriol (Compound) and Calcipotriol (Compound) resembles Paricalcitol (Compound)
Ritonavir (Compound) resembles Carfilzomib (Compound) and Carfilzomib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Paricalcitol (Compound)
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paricalcitol (Compound)