DDInter553 DDInter1763
A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) upregulates {v} (Gene) CBLB
CBLB {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) downregulates {v} (Gene) TCEA2
TCEA2 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) downregulates {v} (Gene) ICAM3
ICAM3 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) upregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Digitoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) upregulates {v} (Gene) CBLB
CBLB {u} (Gene) is upregulated by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Digitoxin {u} (Compound) upregulates {v} (Gene) SNX13
SNX13 {u} (Gene) is regulated by {v} (Gene) MBTPS1
MBTPS1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Temsirolimus (Compound)
Digitoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)
Digitoxin (Compound) upregulates CBLB (Gene) and CBLB (Gene) is upregulated by Temsirolimus (Compound)
Digitoxin (Compound) downregulates TCEA2 (Gene) and TCEA2 (Gene) is upregulated by Temsirolimus (Compound)
Digitoxin (Compound) downregulates ICAM3 (Gene) and ICAM3 (Gene) is downregulated by Temsirolimus (Compound)
Digitoxin (Compound) upregulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Temsirolimus (Compound)
Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Digitoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Digitoxin (Compound) upregulates CBLB (Gene) and CBLB (Gene) is upregulated by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Digitoxin (Compound) upregulates SNX13 (Gene) and SNX13 (Gene) is regulated by MBTPS1 (Gene) and MBTPS1 (Gene) is upregulated by Temsirolimus (Compound)