DDInter477 DDInter1464
Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal tryptophan covalently bonded to decanoic acid.[A231374, L32534] Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil samples from Mount Ararat in Turkey. Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed d
Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in European countries for many years.
Picosulfuric acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Picosulfuric acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methylcellulose
Picosulfuric acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimipramine
Picosulfuric acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Picosulfuric acid {u} may lead to a major life threatening interaction when taken with {v} Sotalol
Picosulfuric acid may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Picosulfuric acid may cause a minor interaction that can limit clinical effects when taken with Methylcellulose
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Picosulfuric acid may lead to a major life threatening interaction when taken with Sotalol