DDInter1420 DDInter740
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Pentamidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Flecainide
Pentamidine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Flecainide
Pentamidine {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Flecainide
Pentamidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mefloquine
Mefloquine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Flecainide
Pentamidine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Pentamidine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is regulated by {v} (Gene) GARS
GARS {u} (Gene) is upregulated by {v} (Compound) Flecainide
Pentamidine {u} (Compound) upregulates {v} (Gene) AARS
AARS {u} (Gene) regulates {v} (Gene) DNAJA3
DNAJA3 {u} (Gene) is downregulated by {v} (Compound) Flecainide
Pentamidine {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Mefloquine
Mefloquine {u} (Compound) resembles {v} (Compound) Flecainide
Pentamidine {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) regulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is upregulated by {v} (Compound) Flecainide
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine (Compound) resembles Flecainide (Compound)
Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Flecainide (Compound)
Pentamidine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Flecainide (Compound)
Pentamidine (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Flecainide (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Flecainide (Compound)
Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Pentamidine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is regulated by GARS (Gene) and GARS (Gene) is upregulated by Flecainide (Compound)
Pentamidine (Compound) upregulates AARS (Gene) and AARS (Gene) regulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Flecainide (Compound)
Pentamidine (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Mefloquine (Compound) and Mefloquine (Compound) resembles Flecainide (Compound)
Pentamidine (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) regulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Flecainide (Compound)