DDInter548 DDInter299
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ritonavir
Ritonavir {u} (Compound) resembles {v} (Compound) Carfilzomib
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydroxychloroquine
Hydroxychloroquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) downregulates {v} (Gene) PSMB10
PSMB10 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Eltrombopag
Eltrombopag {u} may lead to a major life threatening interaction when taken with {v} Carfilzomib
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Ritodrine
Ritodrine {u} may lead to a major life threatening interaction when taken with {v} Crizotinib
Crizotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Diethylstilbestrol {u} (Compound) resembles {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Diethylstilbestrol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) interacts with {v} (Gene) PSMB8
PSMB8 {u} (Gene) is bound by {v} (Compound) Carfilzomib
Diethylstilbestrol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Teniposide
Teniposide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carfilzomib
Diethylstilbestrol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound)
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen may lead to a major life threatening interaction when taken with Carfilzomib
Diethylstilbestrol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ritonavir (Compound) and Ritonavir (Compound) resembles Carfilzomib (Compound)
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) downregulates PSMB10 (Gene) and PSMB10 (Gene) is bound by Carfilzomib (Compound)
Diethylstilbestrol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Eltrombopag (Compound) and Eltrombopag may lead to a major life threatening interaction when taken with Carfilzomib
Diethylstilbestrol (Compound) resembles Ritodrine (Compound) and Ritodrine may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Diethylstilbestrol (Compound) resembles Tamoxifen (Compound) and Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carfilzomib (Compound)
Diethylstilbestrol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) interacts with PSMB8 (Gene) and PSMB8 (Gene) is bound by Carfilzomib (Compound)
Diethylstilbestrol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Teniposide (Compound) and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib