DDInter1397 DDInter297
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is upregulated by {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Paroxetine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Paroxetine {u} (Compound) downregulates {v} (Gene) SUV39H1
SUV39H1 {u} (Gene) is downregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} (Compound) resembles {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) upregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Paroxetine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Dexbrompheniramine
Dexbrompheniramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carbinoxamine
Paroxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carbinoxamine (Compound)
Paroxetine (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is upregulated by Carbinoxamine (Compound)
Paroxetine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Carbinoxamine (Compound)
Paroxetine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Carbinoxamine (Compound)
Paroxetine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Carbinoxamine (Compound)
Paroxetine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Paroxetine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Paroxetine (Compound) downregulates SUV39H1 (Gene) and SUV39H1 (Gene) is downregulated by Bisacodyl (Compound) and Bisacodyl (Compound) resembles Carbinoxamine (Compound)
Paroxetine (Compound) upregulates TRIB3 (Gene) and TRIB3 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Carbinoxamine (Compound)
Paroxetine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Dexbrompheniramine (Compound) and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine