DDInter336 DDInter1161
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse. The FDA withdrew its approval for the use of all parenteral drug products containing methamphetamine hydrochloride, a metamfetamine salt.
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Metamfetamine
Celecoxib {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Metamfetamine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Phenformin
Phenformin {u} (Compound) resembles {v} (Compound) Metamfetamine
Celecoxib {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Benzphetamine
Benzphetamine {u} (Compound) resembles {v} (Compound) Metamfetamine
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Benzphetamine
Benzphetamine {u} (Compound) resembles {v} (Compound) Metamfetamine
Celecoxib {u} (Compound) causes {v} (Side Effect) Constipation
Constipation {u} (Side Effect) is caused by {v} (Compound) Lacosamide
Lacosamide {u} (Compound) resembles {v} (Compound) Metamfetamine
Celecoxib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Alogliptin
Alogliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metamfetamine
Celecoxib {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Dexfenfluramine
Dexfenfluramine {u} may lead to a major life threatening interaction when taken with {v} Metamfetamine
Celecoxib {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Ephedrine
Ephedrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metamfetamine
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Alogliptin
Alogliptin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metamfetamine
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metamfetamine (Compound)
Celecoxib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Metamfetamine (Compound)
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Phenformin (Compound) and Phenformin (Compound) resembles Metamfetamine (Compound)
Celecoxib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Benzphetamine (Compound) and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Benzphetamine (Compound) and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Celecoxib (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Lacosamide (Compound) and Lacosamide (Compound) resembles Metamfetamine (Compound)
Celecoxib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alogliptin (Compound) and Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine
Celecoxib (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dexfenfluramine (Compound) and Dexfenfluramine may lead to a major life threatening interaction when taken with Metamfetamine
Celecoxib (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Ephedrine (Compound) and Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine
Celecoxib (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Alogliptin (Compound) and Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine