DDInter1158 DDInter1489
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line.
Mesalazine {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Polymyxin B
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Mesalazine {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Octreotide
Octreotide {u} (Compound) resembles {v} (Compound) Polymyxin B
Mesalazine {u} (Compound) causes {v} (Side Effect) Musculoskeletal stiffness
Musculoskeletal stiffness {u} (Side Effect) is caused by {v} (Compound) Ibandronate
Ibandronate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Mesalazine {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Octreotide
Octreotide {u} (Compound) resembles {v} (Compound) Polymyxin B
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bacitracin
Bacitracin {u} (Compound) resembles {v} (Compound) Polymyxin B
Mesalazine {u} (Compound) causes {v} (Side Effect) Albuminuria
Albuminuria {u} (Side Effect) is caused by {v} (Compound) Verteporfin
Verteporfin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Polymyxin B
Mesalazine {u} (Compound) causes {v} (Side Effect) Drug fever
Drug fever {u} (Side Effect) is caused by {v} (Compound) Kanamycin
Kanamycin {u} may lead to a major life threatening interaction when taken with {v} Polymyxin B
Mesalazine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Terlipressin
Terlipressin {u} (Compound) resembles {v} (Compound) Polymyxin B
Mesalazine {u} (Compound) binds {v} (Gene) MPO
MPO {u} (Gene) is bound by {v} (Compound) Oxaliplatin
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Polymyxin B
Mesalazine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Polymyxin B (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B
Mesalazine (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Octreotide (Compound) and Octreotide (Compound) resembles Polymyxin B (Compound)
Mesalazine (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Ibandronate (Compound) and Ibandronate may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B
Mesalazine (Compound) binds MPO (Gene) and MPO (Gene) is bound by Octreotide (Compound) and Octreotide (Compound) resembles Polymyxin B (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Polymyxin B (Compound)
Mesalazine (Compound) causes Albuminuria (Side Effect) and Albuminuria (Side Effect) is caused by Verteporfin (Compound) and Verteporfin may cause a minor interaction that can limit clinical effects when taken with Polymyxin B
Mesalazine (Compound) causes Drug fever (Side Effect) and Drug fever (Side Effect) is caused by Kanamycin (Compound) and Kanamycin may lead to a major life threatening interaction when taken with Polymyxin B
Mesalazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Terlipressin (Compound) and Terlipressin (Compound) resembles Polymyxin B (Compound)
Mesalazine (Compound) binds MPO (Gene) and MPO (Gene) is bound by Oxaliplatin (Compound) and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Polymyxin B