DDInter1141 DDInter1215
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).
Megestrol acetate {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) is bound by {v} (Compound) Mifepristone
Megestrol acetate {u} (Compound) resembles {v} (Compound) Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mifepristone
Megestrol acetate {u} (Compound) resembles {v} (Compound) Fludrocortisone
Fludrocortisone {u} may lead to a major life threatening interaction when taken with {v} Mifepristone
Megestrol acetate {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) interacts with {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Mifepristone
Megestrol acetate {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) IL1B
IL1B {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Megestrol acetate {u} (Compound) binds {v} (Gene) PGR
PGR {u} (Gene) interacts with {v} (Gene) CCNA1
CCNA1 {u} (Gene) is upregulated by {v} (Compound) Mifepristone
Megestrol acetate {u} (Compound) resembles {v} (Compound) Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) is bound by {v} (Compound) Mifepristone
Megestrol acetate {u} (Compound) resembles {v} (Compound) Fludrocortisone
Fludrocortisone {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) is bound by {v} (Compound) Mifepristone
Megestrol acetate {u} (Compound) resembles {v} (Compound) Dydrogesterone
Dydrogesterone {u} (Compound) resembles {v} (Compound) Hydrocortisone
Hydrocortisone {u} may lead to a major life threatening interaction when taken with {v} Mifepristone
Megestrol acetate {u} (Compound) binds {v} (Gene) PGR
PGR {u} (Gene) is bound by {v} (Compound) Medroxyprogesterone acetate
Medroxyprogesterone acetate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mifepristone
Megestrol acetate (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is bound by Mifepristone (Compound)
Megestrol acetate (Compound) resembles Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone
Megestrol acetate (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may lead to a major life threatening interaction when taken with Mifepristone
Megestrol acetate (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) interacts with AR (Gene) and AR (Gene) is bound by Mifepristone (Compound)
Megestrol acetate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates IL1B (Gene) and IL1B (Gene) is upregulated by Mifepristone (Compound)
Megestrol acetate (Compound) binds PGR (Gene) and PGR (Gene) interacts with CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Mifepristone (Compound)
Megestrol acetate (Compound) resembles Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is bound by Mifepristone (Compound)
Megestrol acetate (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is bound by Mifepristone (Compound)
Megestrol acetate (Compound) resembles Dydrogesterone (Compound) and Dydrogesterone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may lead to a major life threatening interaction when taken with Mifepristone
Megestrol acetate (Compound) binds PGR (Gene) and PGR (Gene) is bound by Medroxyprogesterone acetate (Compound) and Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone