DDInter1397 DDInter840
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Granisetron
Paroxetine {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Granisetron
Paroxetine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Granisetron
Paroxetine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Primaquine
Primaquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Granisetron
Paroxetine {u} (Compound) downregulates {v} (Gene) EBNA1BP2
EBNA1BP2 {u} (Gene) is downregulated by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Granisetron
Paroxetine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Granisetron
Paroxetine {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Hyoscyamine
Hyoscyamine {u} (Compound) resembles {v} (Compound) Granisetron
Paroxetine {u} (Compound) causes {v} (Side Effect) Liver function test abnormal
Liver function test abnormal {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Granisetron
Paroxetine {u} (Compound) causes {v} (Side Effect) Hyperphosphataemia
Hyperphosphataemia {u} (Side Effect) is caused by {v} (Compound) Foscarnet
Foscarnet {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Granisetron
Paroxetine {u} (Compound) causes {v} (Side Effect) Epistaxis
Epistaxis {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Granisetron
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Granisetron (Compound)
Paroxetine (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Granisetron (Compound)
Paroxetine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Granisetron (Compound)
Paroxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound) and Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Granisetron
Paroxetine (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Granisetron
Paroxetine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Granisetron (Compound)
Paroxetine (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Hyoscyamine (Compound) and Hyoscyamine (Compound) resembles Granisetron (Compound)
Paroxetine (Compound) causes Liver function test abnormal (Side Effect) and Liver function test abnormal (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Granisetron
Paroxetine (Compound) causes Hyperphosphataemia (Side Effect) and Hyperphosphataemia (Side Effect) is caused by Foscarnet (Compound) and Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Granisetron
Paroxetine (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Granisetron