DDInter217 DDInter1266
Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketoprofen
Ketoprofen {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clove
Clove {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nabumetone
Nabumetone {u} (Compound) resembles {v} (Compound) Agomelatine
Agomelatine {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Piroxicam
Piroxicam {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Verteporfin
Verteporfin {u} (Compound) causes {v} (Side Effect) Inflammation
Inflammation {u} (Side Effect) is caused by {v} (Compound) Naproxen
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) treats {v} (Disease) gout
gout {u} (Disease) is treated by {v} (Compound) Naproxen
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Suprofen (Compound) and Suprofen (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ibuprofen and Ibuprofen (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Nabumetone and Nabumetone (Compound) resembles Agomelatine (Compound) and Agomelatine (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) binds ALB (Gene) and ALB (Gene) is bound by Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Verteporfin and Verteporfin (Compound) causes Inflammation (Side Effect) and Inflammation (Side Effect) is caused by Naproxen (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) treats gout (Disease) and gout (Disease) is treated by Naproxen (Compound)