DDInter1041 DDInter1181
Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. Despite this difference in activity, the two commercially available forms have been shown to be pharmacokinetically identical and may be used interchangeably with limited differences in efficacy or side effects (Kovoor et al, 2009). As folate analogs, leucovor
Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ethotoin
Ethotoin {u} (Compound) resembles {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Meperidine
Meperidine {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Phenytoin
Phenytoin {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phensuximide
Phensuximide {u} (Compound) resembles {v} (Compound) Clobazam
Clobazam {u} (Compound) resembles {v} (Compound) Methsuximide
Leucovorin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenytoin
Phenytoin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Methsuximide
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Methsuximide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Methsuximide (Compound)
Leucovorin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Methsuximide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Phenytoin (Compound) and Phenytoin (Compound) resembles Methsuximide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital (Compound) resembles Methsuximide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Phenobarbital (Compound) and Phenobarbital (Compound) resembles Methsuximide (Compound)
Leucovorin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Meperidine (Compound) and Meperidine (Compound) resembles Methsuximide (Compound)
Leucovorin (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Phenytoin (Compound) and Phenytoin (Compound) resembles Methsuximide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Clobazam (Compound) and Clobazam (Compound) resembles Methsuximide (Compound)
Leucovorin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Methsuximide (Compound)