DDInter351 DDInter1956
An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.[L43942,L44022]
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Chloramphenicol {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Chloramphenicol {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Zalcitabine
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cytarabine
Cytarabine {u} (Compound) resembles {v} (Compound) Gemcitabine
Gemcitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Didanosine
Didanosine {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Zalcitabine
Chloramphenicol {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Chloramphenicol {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Zalcitabine
Chloramphenicol {u} (Compound) causes {v} (Side Effect) Abdominal distension
Abdominal distension {u} (Side Effect) is caused by {v} (Compound) Lamivudine
Lamivudine {u} (Compound) resembles {v} (Compound) Zalcitabine
Chloramphenicol {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Decitabine
Decitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Floxuridine
Floxuridine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} (Compound) resembles {v} (Compound) Zalcitabine
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Zalcitabine (Compound)
Chloramphenicol (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Chloramphenicol (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Zalcitabine (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine and Cytarabine (Compound) resembles Gemcitabine (Compound) and Gemcitabine (Compound) resembles Zalcitabine (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Zalcitabine (Compound)
Chloramphenicol (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Chloramphenicol (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Zalcitabine (Compound)
Chloramphenicol (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Lamivudine (Compound) and Lamivudine (Compound) resembles Zalcitabine (Compound)
Chloramphenicol (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Decitabine (Compound) and Decitabine (Compound) resembles Zalcitabine (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) resembles Emtricitabine (Compound) and Emtricitabine (Compound) resembles Zalcitabine (Compound)