DDInter485 DDInter1376
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Daunorubicin {u} (Compound) resembles {v} (Compound) Doxorubicin
Daunorubicin {u} (Compound) resembles {v} (Compound) Valrubicin
Daunorubicin {u} (Compound) treats {v} (Disease) hematologic cancer
Daunorubicin {u} (Compound) binds {v} (Gene) CYP1A2
Daunorubicin {u} (Compound) upregulates {v} (Gene) GDI1
Daunorubicin {u} (Compound) is included by {v} (Pharmacologic Class) Topoisomerase Inhibitors
Daunorubicin {u} (Compound) downregulates {v} (Gene) TAF5
Daunorubicin {u} (Compound) causes {v} (Side Effect) Sickness
Daunorubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Daunorubicin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Enoxacin
Daunorubicin (Compound) resembles Doxorubicin (Compound)
Daunorubicin (Compound) resembles Valrubicin (Compound)
Daunorubicin (Compound) treats hematologic cancer (Disease)
Daunorubicin (Compound) binds CYP1A2 (Gene)
Daunorubicin (Compound) upregulates GDI1 (Gene)
Daunorubicin (Compound) is included by Topoisomerase Inhibitors (Pharmacologic Class)
Daunorubicin (Compound) downregulates TAF5 (Gene)
Daunorubicin (Compound) causes Sickness (Side Effect)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Enoxacin