DDInter1266 DDInter1055
Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile. Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. Naproxen is available in both immediate and delayed release formulations, in combination with sumatriptan to treat migraines, and in combination with esomeprazole to lower the risk of developing gastric ulcers.
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Naproxen {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Naproxen {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Naproxen {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Enoxacin
Enoxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Naproxen {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Naproxen {u} (Compound) causes {v} (Side Effect) Metrorrhagia
Metrorrhagia {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Naproxen {u} (Compound) resembles {v} (Compound) Suprofen
Suprofen {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Naproxen {u} (Compound) resembles {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Nabumetone {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Naproxen {u} (Compound) resembles {v} (Compound) Nabumetone
Nabumetone {u} (Compound) causes {v} (Side Effect) Dysphagia
Dysphagia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Naproxen {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is associated with {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Naproxen (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Naproxen (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Naproxen (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Enoxacin (Compound) and Enoxacin (Compound) resembles Levofloxacin (Compound)
Naproxen (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Naproxen (Compound) causes Metrorrhagia (Side Effect) and Metrorrhagia (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Naproxen (Compound) resembles Suprofen (Compound) and Suprofen (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is downregulated by Levofloxacin (Compound)
Naproxen (Compound) resembles Fenoprofen (Compound) and Fenoprofen (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Levofloxacin (Compound)
Naproxen (Compound) resembles Nabumetone (Compound) and Nabumetone (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)
Naproxen (Compound) resembles Nabumetone (Compound) and Nabumetone (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Levofloxacin (Compound)
Naproxen (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is associated with chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)