DDInter1075 DDInter1082
Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.
Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type II diabetes mellitus (T2DM). It is sold by Sanofi-Aventis under the brand name Adlyxin in the US and Lyxumia in the EU. Adlyxin recieved FDA approval July 28, 2016.
Liotrix {u} (Compound) resembles {v} (Compound) Liothyronine
Liotrix {u} (Compound) resembles {v} (Compound) Levothyroxine
Liotrix {u} (Compound) treats {v} (Disease) hypothyroidism
Liotrix {u} (Compound) binds {v} (Gene) SLCO1B1
Liotrix {u} (Compound) upregulates {v} (Gene) ABCC5
Liotrix {u} (Compound) downregulates {v} (Gene) CDC20
Liotrix {u} (Compound) causes {v} (Side Effect) Constipation
Liotrix {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Liotrix {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Albiglutide
Liotrix {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Liotrix (Compound) resembles Liothyronine (Compound)
Liotrix (Compound) resembles Levothyroxine (Compound)
Liotrix (Compound) treats hypothyroidism (Disease)
Liotrix (Compound) binds SLCO1B1 (Gene)
Liotrix (Compound) upregulates ABCC5 (Gene)
Liotrix (Compound) downregulates CDC20 (Gene)
Liotrix (Compound) causes Constipation (Side Effect)
Liotrix may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide