DDInter1447 DDInter1662
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Phentermine {u} (Compound) binds {v} (Gene) MAOA
MAOA {u} (Gene) is bound by {v} (Compound) Sertraline
Phentermine {u} (Compound) causes {v} (Side Effect) Chest pain
Chest pain {u} (Side Effect) is caused by {v} (Compound) Sertraline
Phentermine {u} (Compound) binds {v} (Gene) MAOA
MAOA {u} (Gene) is associated with {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Sertraline
Phentermine {u} (Compound) binds {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Phentermine {u} (Compound) binds {v} (Gene) MAOB
MAOB {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Phentermine {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Tranylcypromine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Sertraline
Phentermine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pseudoephedrine
Pseudoephedrine {u} (Compound) binds {v} (Gene) SLC6A2
SLC6A2 {u} (Gene) is bound by {v} (Compound) Sertraline
Phentermine {u} (Compound) binds {v} (Gene) MAOA
MAOA {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) binds {v} (Gene) MAOB
MAOB {u} (Gene) is bound by {v} (Compound) Sertraline
Phentermine (Compound) binds MAOA (Gene) and MAOA (Gene) is bound by Sertraline (Compound)
Phentermine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Sertraline (Compound)
Phentermine (Compound) binds MAOA (Gene) and MAOA (Gene) is associated with schizophrenia (Disease) and schizophrenia (Disease) is palliated by Sertraline (Compound)
Phentermine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Phentermine (Compound) binds MAOB (Gene) and MAOB (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)
Phentermine (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Maprotiline (Compound) and Maprotiline (Compound) resembles Sertraline (Compound)
Phentermine (Compound) resembles Tranylcypromine (Compound) and Tranylcypromine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Sertraline (Compound)
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Sertraline (Compound)
Phentermine (Compound) binds MAOA (Gene) and MAOA (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is downregulated by Sertraline (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) binds MAOB (Gene) and MAOB (Gene) is bound by Sertraline (Compound)