DDInter596 DDInter1377
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Doxorubicin {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) ABCC10
ABCC10 {u} (Gene) is bound by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) downregulates {v} (Gene) CDCA8
CDCA8 {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) upregulates {v} (Gene) MMP1
MMP1 {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) AURKA
AURKA {u} (Gene) is upregulated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) downregulates {v} (Gene) SCAND1
SCAND1 {u} (Gene) is downregulated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) upregulates {v} (Gene) ABCB6
ABCB6 {u} (Gene) is downregulated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Paclitaxel
Doxorubicin {u} (Compound) causes {v} (Side Effect) Alanine aminotransferase increased
Alanine aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Paclitaxel
Doxorubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Paclitaxel (Compound)
Doxorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Doxorubicin (Compound) binds ABCC10 (Gene) and Doxorubicin (Compound) upregulates ABCC10 (Gene) and ABCC10 (Gene) is bound by Paclitaxel (Compound)
Doxorubicin (Compound) downregulates CDCA8 (Gene) and CDCA8 (Gene) is upregulated by Paclitaxel (Compound)
Doxorubicin (Compound) upregulates MMP1 (Gene) and MMP1 (Gene) is upregulated by Paclitaxel (Compound)
Doxorubicin (Compound) binds AURKA (Gene) and Doxorubicin (Compound) downregulates AURKA (Gene) and AURKA (Gene) is upregulated by Paclitaxel (Compound)
Doxorubicin (Compound) downregulates SCAND1 (Gene) and SCAND1 (Gene) is downregulated by Paclitaxel (Compound)
Doxorubicin (Compound) upregulates ABCB6 (Gene) and ABCB6 (Gene) is downregulated by Paclitaxel (Compound)
Doxorubicin (Compound) binds TOP2A (Gene) and Doxorubicin (Compound) downregulates TOP2A (Gene) and TOP2A (Gene) is downregulated by Paclitaxel (Compound)
Doxorubicin (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Paclitaxel (Compound)