DDInter650 DDInter1376
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles.[A193650,L12972] Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and [phenylephrine] are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists.[A193701,A193704,L12975] Ephedrine was granted a type 7 FDA
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Ephedrine {u} (Compound) resembles {v} (Compound) Metaraminol
Ephedrine {u} (Compound) resembles {v} (Compound) Etomidate
Ephedrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amphetamine
Ephedrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metamfetamine
Ephedrine {u} (Compound) binds {v} (Gene) ADRB2
Ephedrine {u} (Compound) palliates {v} (Disease) allergic rhinitis
Ephedrine {u} (Compound) downregulates {v} (Gene) COG2
Ephedrine {u} (Compound) causes {v} (Side Effect) Delirium
Ephedrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Diamorphine
Ephedrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dexamethasone
Ephedrine (Compound) resembles Metaraminol (Compound)
Ephedrine (Compound) resembles Etomidate (Compound)
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine
Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine
Ephedrine (Compound) binds ADRB2 (Gene)
Ephedrine (Compound) palliates allergic rhinitis (Disease)
Ephedrine (Compound) downregulates COG2 (Gene)
Ephedrine (Compound) causes Delirium (Side Effect)
Ephedrine may cause a minor interaction that can limit clinical effects when taken with Diamorphine
Ephedrine may cause a minor interaction that can limit clinical effects when taken with Dexamethasone