DDInter1928 DDInter1676
Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications. Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Verapamil {u} (Compound) resembles {v} (Compound) Bevantolol
Verapamil {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Verapamil {u} (Compound) treats {v} (Disease) migraine
Verapamil {u} (Compound) binds {v} (Gene) CACNB2
Verapamil {u} (Compound) upregulates {v} (Gene) MCOLN1
Verapamil {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Verapamil {u} (Compound) downregulates {v} (Gene) DNAJA3
Verapamil {u} (Compound) causes {v} (Side Effect) Diarrhoea
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sibutramine
Verapamil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Verapamil (Compound) resembles Bevantolol (Compound)
Verapamil (Compound) resembles Trimethobenzamide (Compound)
Verapamil (Compound) treats migraine (Disease)
Verapamil (Compound) binds CACNB2 (Gene)
Verapamil (Compound) upregulates MCOLN1 (Gene)
Verapamil (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Verapamil (Compound) downregulates DNAJA3 (Gene)
Verapamil (Compound) causes Diarrhoea (Side Effect)
Verapamil may cause a minor interaction that can limit clinical effects when taken with Sibutramine
Verapamil may cause a minor interaction that can limit clinical effects when taken with Bexarotene