DDInter1938 DDInter139
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.
Vincristine {u} (Compound) upregulates {v} (Gene) IKZF1
IKZF1 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Vincristine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is downregulated by {v} (Compound) Auranofin
Vincristine {u} (Compound) upregulates {v} (Gene) PSMD9
PSMD9 {u} (Gene) is downregulated by {v} (Compound) Auranofin
Vincristine {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Auranofin
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Auranofin
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Auranofin
Vincristine {u} (Compound) upregulates {v} (Gene) IKZF1
IKZF1 {u} (Gene) is regulated by {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Auranofin
Vincristine {u} (Compound) upregulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) regulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Auranofin
Vincristine {u} (Compound) downregulates {v} (Gene) CDC25B
CDC25B {u} (Gene) is regulated by {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Auranofin
Vincristine {u} (Compound) downregulates {v} (Gene) CLTC
CLTC {u} (Gene) is upregulated by {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Auranofin
Vincristine (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Auranofin (Compound)
Vincristine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Auranofin (Compound)
Vincristine (Compound) upregulates PSMD9 (Gene) and PSMD9 (Gene) is downregulated by Auranofin (Compound)
Vincristine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Auranofin (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Auranofin
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Auranofin
Vincristine (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is regulated by TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Auranofin (Compound)
Vincristine (Compound) upregulates ADRB2 (Gene) and ADRB2 (Gene) regulates CPVL (Gene) and CPVL (Gene) is upregulated by Auranofin (Compound)
Vincristine (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is regulated by GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Auranofin (Compound)
Vincristine (Compound) downregulates CLTC (Gene) and CLTC (Gene) is upregulated by rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Auranofin (Compound)