DDInter78 DDInter535
Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Amitriptyline {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) is regulated by {v} (Gene) P4HTM
P4HTM {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) regulates {v} (Gene) RBM34
RBM34 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) downregulates {v} (Gene) MRPS16
MRPS16 {u} (Gene) regulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Amitriptyline {u} (Compound) downregulates {v} (Gene) FABP5
FABP5 {u} (Gene) is regulated by {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Amitriptyline (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Diazoxide (Compound)
Amitriptyline (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Amitriptyline (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Amitriptyline (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is regulated by P4HTM (Gene) and P4HTM (Gene) is upregulated by Diazoxide (Compound)
Amitriptyline (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Amitriptyline (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) regulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Diazoxide (Compound)
Amitriptyline (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) regulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Diazoxide (Compound)
Amitriptyline (Compound) downregulates FABP5 (Gene) and FABP5 (Gene) is regulated by MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Diazoxide (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)