DDInter1040 DDInter119
Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole was granted FDA approval on 25 July 1997.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Letrozole {u} (Compound) resembles {v} (Compound) Bifonazole
Letrozole {u} (Compound) treats {v} (Disease) breast cancer
Letrozole {u} (Compound) binds {v} (Gene) CYP19A1
Letrozole {u} (Compound) upregulates {v} (Gene) KIAA0355
Letrozole {u} (Compound) downregulates {v} (Gene) ACAT2
Letrozole {u} (Compound) causes {v} (Side Effect) Mucosal dryness
Letrozole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Letrozole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Letrozole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Estrone sulfate
Letrozole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Conivaptan
Letrozole (Compound) resembles Bifonazole (Compound)
Letrozole (Compound) treats breast cancer (Disease)
Letrozole (Compound) binds CYP19A1 (Gene)
Letrozole (Compound) upregulates KIAA0355 (Gene)
Letrozole (Compound) downregulates ACAT2 (Gene)
Letrozole (Compound) causes Mucosal dryness (Side Effect)
Letrozole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Letrozole may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Estrone sulfate
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan