DDInter458 DDInter1187
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pergolide
Pergolide {u} (Compound) resembles {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) regulates {v} (Gene) MICALL1
MICALL1 {u} (Gene) is upregulated by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) upregulates {v} (Gene) EDEM1
EDEM1 {u} (Gene) is upregulated by {v} (Compound) Bromocriptine
Bromocriptine {u} (Compound) resembles {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Methylergometrine
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) HS2ST1
HS2ST1 {u} (Gene) is upregulated by {v} (Compound) Methylergometrine
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methylergometrine (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Methylergometrine (Compound)
Cyclosporine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Methylergometrine (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Methylergometrine (Compound)
Cyclosporine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Methylergometrine (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pergolide (Compound) and Pergolide (Compound) resembles Methylergometrine (Compound)
Cyclosporine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) regulates MICALL1 (Gene) and MICALL1 (Gene) is upregulated by Methylergometrine (Compound)
Cyclosporine (Compound) upregulates EDEM1 (Gene) and EDEM1 (Gene) is upregulated by Bromocriptine (Compound) and Bromocriptine (Compound) resembles Methylergometrine (Compound)
Cyclosporine (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by HTR2C (Gene) and HTR2C (Gene) is bound by Methylergometrine (Compound)
Cyclosporine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by HS2ST1 (Gene) and HS2ST1 (Gene) is upregulated by Methylergometrine (Compound)