DDInter54 DDInter535
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse effects are generally related to the sedation it can cause. Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. Alprazolam was given FDA approval on October 16, 1981.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is regulated by {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) regulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is regulated by {v} (Gene) RBM6
RBM6 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) regulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Alprazolam {u} (Compound) upregulates {v} (Gene) KDM5A
KDM5A {u} (Gene) is regulated by {v} (Gene) MRPS16
MRPS16 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Alprazolam (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Diazoxide (Compound)
Alprazolam (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Diazoxide (Compound)
Alprazolam (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Alprazolam (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is regulated by DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Alprazolam (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) regulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Alprazolam (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)
Alprazolam (Compound) downregulates CYCS (Gene) and CYCS (Gene) is regulated by RBM6 (Gene) and RBM6 (Gene) is upregulated by Diazoxide (Compound)
Alprazolam (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Alprazolam (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) regulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Diazoxide (Compound)
Alprazolam (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is regulated by MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Diazoxide (Compound)