DDInter698 DDInter1763
Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]. Etidronic acid was granted FDA approval on 1 September 1977.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Etidronic acid {u} (Compound) downregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) upregulates {v} (Gene) DHX29
DHX29 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) downregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) upregulates {v} (Gene) DHX29
DHX29 {u} (Gene) is regulated by {v} (Gene) MBTPS1
MBTPS1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Everolimus
Everolimus {u} (Compound) resembles {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) resembles {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) downregulates {v} (Gene) ATP6V1D
ATP6V1D {u} (Gene) regulates {v} (Gene) PIGV
PIGV {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Etidronic acid {u} (Compound) upregulates {v} (Gene) DHX29
DHX29 {u} (Gene) regulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Etidronic acid (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) is downregulated by Temsirolimus (Compound)
Etidronic acid (Compound) upregulates DHX29 (Gene) and DHX29 (Gene) is downregulated by Temsirolimus (Compound)
Etidronic acid (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Temsirolimus (Compound)
Etidronic acid (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Temsirolimus (Compound)
Etidronic acid (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Sirolimus (Compound) and Sirolimus (Compound) resembles Temsirolimus (Compound)
Etidronic acid (Compound) upregulates DHX29 (Gene) and DHX29 (Gene) is regulated by MBTPS1 (Gene) and MBTPS1 (Gene) is upregulated by Temsirolimus (Compound)
Etidronic acid (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Everolimus (Compound) and Everolimus (Compound) resembles Temsirolimus (Compound)
Etidronic acid (Compound) resembles Risedronic acid (Compound) and Risedronic acid (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Temsirolimus (Compound)
Etidronic acid (Compound) downregulates ATP6V1D (Gene) and ATP6V1D (Gene) regulates PIGV (Gene) and PIGV (Gene) is upregulated by Temsirolimus (Compound)
Etidronic acid (Compound) upregulates DHX29 (Gene) and DHX29 (Gene) regulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Temsirolimus (Compound)