DDInter1073 DDInter576
Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically, it binds to the 23S ribosomal RNA of the 50S subunit[A11227,A199050] and, in doing so, prevents the formation of the 70S initiation complex which is essential for bacterial reproduction. Linezolid was initially approved in 2000 and was the first member of the oxazolidinone antibiotic class. A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered generally more effective and tolerable than its predecessor.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Linezolid {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) causes {v} (Side Effect) Neuropathy
Neuropathy {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Linezolid {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) regulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) upregulates {v} (Gene) PRKAG2
PRKAG2 {u} (Gene) is regulated by {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is bound by {v} (Compound) Disulfiram
Linezolid {u} (Compound) binds {v} (Gene) MAOB
MAOB {u} (Gene) is associated with {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) binds {v} (Gene) MAOB
MAOB {u} (Gene) regulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) upregulates {v} (Gene) ZFP36
ZFP36 {u} (Gene) is upregulated by {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Linezolid {u} (Compound) binds {v} (Gene) MAOA
MAOA {u} (Gene) is regulated by {v} (Gene) TRAPPC3
TRAPPC3 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Linezolid (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Linezolid (Compound) causes Neuropathy (Side Effect) and Neuropathy (Side Effect) is caused by Disulfiram (Compound)
Linezolid (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Linezolid (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) regulates CTSL (Gene) and CTSL (Gene) is upregulated by Disulfiram (Compound)
Linezolid (Compound) upregulates PRKAG2 (Gene) and PRKAG2 (Gene) is regulated by CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Disulfiram (Compound)
Linezolid (Compound) binds MAOB (Gene) and MAOB (Gene) is associated with alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Linezolid (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) interacts with NFKB2 (Gene) and NFKBIA (Gene) is regulated by NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)
Linezolid (Compound) binds MAOB (Gene) and MAOB (Gene) regulates MAL (Gene) and MAL (Gene) is upregulated by Disulfiram (Compound)
Linezolid (Compound) upregulates ZFP36 (Gene) and ZFP36 (Gene) is upregulated by alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Linezolid (Compound) binds MAOA (Gene) and MAOA (Gene) is regulated by TRAPPC3 (Gene) and TRAPPC3 (Gene) is downregulated by Disulfiram (Compound)