DDInter1460 DDInter535
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.[A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects.[A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Phenytoin {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Phenytoin {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Phenytoin {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) regulates {v} (Gene) USP22
USP22 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Phenytoin {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is regulated by {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Diazoxide
Phenytoin {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Phenytoin {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) is regulated by {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Phenytoin {u} (Compound) downregulates {v} (Gene) CNDP2
CNDP2 {u} (Gene) regulates {v} (Gene) DDX42
DDX42 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Phenytoin {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) is regulated by {v} (Gene) FABP5
FABP5 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxycycline
Doxycycline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxercalciferol
Doxercalciferol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Phenytoin (Compound) downregulates CAST (Gene) and CAST (Gene) is downregulated by Diazoxide (Compound)
Phenytoin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Phenytoin (Compound) downregulates CAST (Gene) and CAST (Gene) regulates USP22 (Gene) and USP22 (Gene) is downregulated by Diazoxide (Compound)
Phenytoin (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is regulated by KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Diazoxide (Compound)
Phenytoin (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Phenytoin (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) is regulated by KRT19 (Gene) and KRT19 (Gene) is upregulated by Diazoxide (Compound)
Phenytoin (Compound) downregulates CNDP2 (Gene) and CNDP2 (Gene) regulates DDX42 (Gene) and DDX42 (Gene) is upregulated by Diazoxide (Compound)
Phenytoin (Compound) downregulates CAST (Gene) and CAST (Gene) is regulated by FABP5 (Gene) and FABP5 (Gene) is downregulated by Diazoxide (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxercalciferol and Doxercalciferol may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)