DDInter1358 DDInter899
Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Oxaprozin {u} (Compound) resembles {v} (Compound) Benzphetamine
Oxaprozin {u} (Compound) resembles {v} (Compound) Phenytoin
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Oxaprozin {u} (Compound) binds {v} (Gene) PTGS1
Oxaprozin {u} (Compound) palliates {v} (Disease) rheumatoid arthritis
Oxaprozin {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Oxaprozin {u} (Compound) causes {v} (Side Effect) Glossitis
Oxaprozin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Oxaprozin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Linaclotide
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cangrelor
Oxaprozin (Compound) resembles Benzphetamine (Compound)
Oxaprozin (Compound) resembles Phenytoin (Compound)
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Oxaprozin (Compound) binds PTGS1 (Gene)
Oxaprozin (Compound) palliates rheumatoid arthritis (Disease)
Oxaprozin (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Oxaprozin (Compound) causes Glossitis (Side Effect)
Oxaprozin may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Oxaprozin may cause a minor interaction that can limit clinical effects when taken with Linaclotide
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor