DDInter1808 DDInter278
Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone. Tiludronic acid was granted FDA approval on 7 March 1997.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Tiludronic acid {u} (Compound) treats {v} (Disease) Paget's disease of bone
Tiludronic acid {u} (Compound) binds {v} (Gene) ATP6V1A
Tiludronic acid {u} (Compound) is included by {v} (Pharmacologic Class) Diphosphonates
Tiludronic acid {u} (Compound) causes {v} (Side Effect) Diarrhoea
Tiludronic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetraferric tricitrate decahydrate
Tiludronic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Tiludronic acid {u} may lead to a major life threatening interaction when taken with {v} Etelcalcetide
Tiludronic acid (Compound) treats Paget's disease of bone (Disease)
Tiludronic acid (Compound) binds ATP6V1A (Gene)
Tiludronic acid (Compound) is included by Diphosphonates (Pharmacologic Class)
Tiludronic acid (Compound) causes Diarrhoea (Side Effect)
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Tetraferric tricitrate decahydrate
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Tiludronic acid may lead to a major life threatening interaction when taken with Etelcalcetide