DDInter1140 DDInter89
Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortality; 90% of deaths from malaria occur in Africa. Individuals at the highest risk for malaria are those in disease naïve populations, children under age 5, refugees in Central and Eastern Africa, nonimmune civilian and military travelers, pregnant women, and immigrants traveling to their place of origin. Mefloquine, commonly known as Lariam, is an antimalarial drug used for the prevention and treatment of malaria caused by infection with Plasmodium vivax and Plasmodium falciparum. The drug was initially discovered by the Walter Reed Army Institute of Research (WRAIR) during a malaria drug discovery program between 196
Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Mefloquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bacampicillin
Bacampicillin {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nafcillin
Nafcillin {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Ampicillin
Mefloquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bacampicillin
Bacampicillin {u} (Compound) resembles {v} (Compound) Meticillin
Meticillin {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nafcillin
Nafcillin {u} (Compound) resembles {v} (Compound) Meticillin
Meticillin {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Cefaclor
Cefaclor {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Cefradine
Cefradine {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nafcillin
Nafcillin {u} (Compound) resembles {v} (Compound) Mezlocillin
Mezlocillin {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Picosulfuric acid
Picosulfuric acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cefradine
Cefradine {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bacampicillin
Bacampicillin {u} (Compound) resembles {v} (Compound) Mezlocillin
Mezlocillin {u} (Compound) resembles {v} (Compound) Ampicillin
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Bacampicillin and Bacampicillin (Compound) resembles Ampicillin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Ampicillin (Compound)
Mefloquine (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Ampicillin (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Bacampicillin and Bacampicillin (Compound) resembles Meticillin (Compound) and Meticillin (Compound) resembles Ampicillin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Meticillin (Compound) and Meticillin (Compound) resembles Ampicillin (Compound)
Mefloquine (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Cefaclor (Compound) and Cefaclor (Compound) resembles Ampicillin (Compound)
Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cefradine (Compound) and Cefradine (Compound) resembles Ampicillin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Mezlocillin (Compound) and Mezlocillin (Compound) resembles Ampicillin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid and Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Cefradine and Cefradine (Compound) resembles Ampicillin (Compound)
Mefloquine may cause a minor interaction that can limit clinical effects when taken with Bacampicillin and Bacampicillin (Compound) resembles Mezlocillin (Compound) and Mezlocillin (Compound) resembles Ampicillin (Compound)