DDInter99 DDInter1662
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etodolac
Etodolac {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etodolac
Etodolac {u} (Compound) upregulates {v} (Gene) MAL
MAL {u} (Gene) is upregulated by {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} (Compound) downregulates {v} (Gene) CSRP1
CSRP1 {u} (Gene) is downregulated by {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etodolac
Etodolac {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Anaphylactic shock {u} (Side Effect) is caused by {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is upregulated by {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxetine
Fluoxetine {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) is palliated by {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fenfluramine
Fenfluramine {u} may lead to a major life threatening interaction when taken with {v} Maprotiline
Maprotiline {u} (Compound) resembles {v} (Compound) Sertraline
Anistreplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Treprostinil {u} (Compound) upregulates {v} (Gene) MELK
MELK {u} (Gene) is downregulated by {v} (Compound) Sertraline
Anistreplase {u} may lead to a major life threatening interaction when taken with {v} Tirofiban
Tirofiban {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Sertraline
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac and Etodolac (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac and Etodolac (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Etodolac and Etodolac (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) is upregulated by Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) is palliated by Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may lead to a major life threatening interaction when taken with Maprotiline and Maprotiline (Compound) resembles Sertraline (Compound)
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) upregulates MELK (Gene) and MELK (Gene) is downregulated by Sertraline (Compound)
Anistreplase may lead to a major life threatening interaction when taken with Tirofiban and Tirofiban (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Sertraline (Compound)