DDInter21 DDInter1435
An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Acitretin {u} (Compound) resembles {v} (Compound) Vitamin A
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Acitretin {u} (Compound) treats {v} (Disease) psoriasis
Acitretin {u} (Compound) binds {v} (Gene) RBP1
Acitretin {u} (Compound) upregulates {v} (Gene) RAP1GAP
Acitretin {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Acitretin {u} (Compound) downregulates {v} (Gene) DNAJA3
Acitretin {u} (Compound) causes {v} (Side Effect) Optic neuritis
Acitretin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Asparaginase Erwinia chrysanthemi
Acitretin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Interferon beta-1a
Acitretin (Compound) resembles Vitamin A (Compound)
Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Acitretin (Compound) treats psoriasis (Disease)
Acitretin (Compound) binds RBP1 (Gene)
Acitretin (Compound) upregulates RAP1GAP (Gene)
Acitretin (Compound) is included by Retinoids (Pharmacologic Class)
Acitretin (Compound) downregulates DNAJA3 (Gene)
Acitretin (Compound) causes Optic neuritis (Side Effect)
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a