DDInter1853 DDInter119
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) treats {v} (Disease) peripheral nervous system neoplasm
Tretinoin {u} (Compound) binds {v} (Gene) CYP1A1
Tretinoin {u} (Compound) upregulates {v} (Gene) DHRS3
Tretinoin {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Tretinoin {u} (Compound) downregulates {v} (Gene) ATP6V1D
Tretinoin {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Tretinoin (Compound) resembles Isotretinoin (Compound)
Tretinoin (Compound) treats peripheral nervous system neoplasm (Disease)
Tretinoin (Compound) binds CYP1A1 (Gene)
Tretinoin (Compound) upregulates DHRS3 (Gene)
Tretinoin (Compound) is included by Retinoids (Pharmacologic Class)
Tretinoin (Compound) downregulates ATP6V1D (Gene)
Tretinoin (Compound) causes Agranulocytosis (Side Effect)