DDInter458 DDInter1423
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Pentobarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Pentobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Pentobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is regulated by {v} (Gene) CDK4
CDK4 {u} (Gene) is downregulated by {v} (Compound) Pentobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Butabarbital
Butabarbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentobarbital
Cyclosporine {u} (Compound) downregulates {v} (Gene) BRCA1
BRCA1 {u} (Gene) is downregulated by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pentobarbital
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentobarbital
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abdominal pain
Abdominal pain {u} (Side Effect) is caused by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentobarbital
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Pentobarbital (Compound)
Cyclosporine (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Pentobarbital (Compound)
Cyclosporine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Pentobarbital (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Phenobarbital (Compound) and Phenobarbital (Compound) resembles Pentobarbital (Compound)
Cyclosporine (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is regulated by CDK4 (Gene) and CDK4 (Gene) is downregulated by Pentobarbital (Compound)
Cyclosporine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Butabarbital (Compound) and Butabarbital (Compound) resembles Pentobarbital (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Pentobarbital
Cyclosporine (Compound) downregulates BRCA1 (Gene) and BRCA1 (Gene) is downregulated by Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pentobarbital
Cyclosporine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pentobarbital