DDInter1619 DDInter1951
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Warfarin
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Ropinirole {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Benzyl Benzoate
Benzyl Benzoate {u} (Compound) resembles {v} (Compound) Warfarin
Ropinirole {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Methotrexate
Methotrexate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Phenytoin
Phenytoin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Fluvastatin
Fluvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Ropinirole {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Chloramphenicol
Chloramphenicol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Ropinirole {u} (Compound) causes {v} (Side Effect) Hearing impaired
Hearing impaired {u} (Side Effect) is caused by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Warfarin
Ropinirole {u} (Compound) causes {v} (Side Effect) Burning sensation
Burning sensation {u} (Side Effect) is caused by {v} (Compound) Tinidazole
Tinidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Warfarin (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Acenocoumarol (Compound) and Acenocoumarol (Compound) resembles Warfarin (Compound)
Ropinirole (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Benzyl Benzoate (Compound) and Benzyl Benzoate (Compound) resembles Warfarin (Compound)
Ropinirole (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Methotrexate (Compound) and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Warfarin
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Warfarin
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Phenytoin (Compound) and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Fluvastatin (Compound) and Fluvastatin may cause a minor interaction that can limit clinical effects when taken with Warfarin
Ropinirole (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Chloramphenicol (Compound) and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Ropinirole (Compound) causes Hearing impaired (Side Effect) and Hearing impaired (Side Effect) is caused by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Warfarin (Compound)
Ropinirole (Compound) causes Burning sensation (Side Effect) and Burning sensation (Side Effect) is caused by Tinidazole (Compound) and Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Warfarin