DDInter1279 DDInter1376
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Neostigmine {u} (Compound) resembles {v} (Compound) Pyridostigmine
Neostigmine {u} (Compound) resembles {v} (Compound) Demecarium
Neostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Edrophonium
Neostigmine {u} (Compound) binds {v} (Gene) BCHE
Neostigmine {u} (Compound) upregulates {v} (Gene) RPP38
Neostigmine {u} (Compound) downregulates {v} (Gene) CD320
Neostigmine {u} (Compound) causes {v} (Side Effect) Post procedural nausea
Neostigmine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Neostigmine {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Neostigmine (Compound) resembles Pyridostigmine (Compound)
Neostigmine (Compound) resembles Demecarium (Compound)
Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium
Neostigmine (Compound) binds BCHE (Gene)
Neostigmine (Compound) upregulates RPP38 (Gene)
Neostigmine (Compound) downregulates CD320 (Gene)
Neostigmine (Compound) causes Post procedural nausea (Side Effect)
Neostigmine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Neostigmine may lead to a major life threatening interaction when taken with Iohexol