DDInter202 DDInter1853
Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bexarotene {u} (Compound) binds {v} (Gene) RXRB
RXRB {u} (Gene) is bound by {v} (Compound) Tretinoin
Bexarotene {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Retinoids {u} (Pharmacologic Class) includes {v} (Compound) Tretinoin
Bexarotene {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Tretinoin
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Tretinoin
Bexarotene {u} may lead to a major life threatening interaction when taken with {v} Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bexarotene {u} (Compound) binds {v} (Gene) RXRB
RXRB {u} (Gene) is bound by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bexarotene {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Tretinoin
Bexarotene {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Retinoids {u} (Pharmacologic Class) includes {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bexarotene {u} (Compound) causes {v} (Side Effect) Blood alkaline phosphatase increased
Blood alkaline phosphatase increased {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} (Compound) resembles {v} (Compound) Tretinoin
Bexarotene may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Bexarotene (Compound) binds RXRB (Gene) and RXRB (Gene) is bound by Tretinoin (Compound)
Bexarotene (Compound) is included by Retinoids (Pharmacologic Class) and Retinoids (Pharmacologic Class) includes Tretinoin (Compound)
Bexarotene (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Tretinoin (Compound)
Bexarotene may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Tretinoin (Compound)
Bexarotene may lead to a major life threatening interaction when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin (Compound) resembles Tretinoin (Compound)
Bexarotene (Compound) binds RXRB (Gene) and RXRB (Gene) is bound by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Tretinoin (Compound)
Bexarotene (Compound) is included by Retinoids (Pharmacologic Class) and Retinoids (Pharmacologic Class) includes Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)
Bexarotene (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin (Compound) resembles Tretinoin (Compound)