DDInter1042 DDInter1118
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially as a fire retardant. It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers).
Magnesium hydroxide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quazepam
Magnesium hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenamide
Magnesium hydroxide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Deutetrabenazine
Magnesium hydroxide {u} may lead to a major life threatening interaction when taken with {v} Erdafitinib
Magnesium hydroxide {u} may lead to a major life threatening interaction when taken with {v} Tolevamer
Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Quazepam
Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide
Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Magnesium hydroxide may lead to a major life threatening interaction when taken with Erdafitinib
Magnesium hydroxide may lead to a major life threatening interaction when taken with Tolevamer