DDInter1639 DDInter1874
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.
Sapropterin {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Trimethoprim
Sapropterin {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Montelukast
Montelukast {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Sapropterin {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Trimethobenzamide
Trimethobenzamide {u} (Compound) resembles {v} (Compound) Trimethoprim
Sapropterin {u} (Compound) causes {v} (Side Effect) Convulsion
Convulsion {u} (Side Effect) is caused by {v} (Compound) Trimetrexate
Trimetrexate {u} (Compound) resembles {v} (Compound) Trimethoprim
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Dapsone
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Sapropterin {u} (Compound) causes {v} (Side Effect) Cough
Cough {u} (Side Effect) is caused by {v} (Compound) Treprostinil
Treprostinil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Sapropterin {u} (Compound) upregulates {v} (Gene) SATB1
SATB1 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Trimethoprim
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) regulates {v} (Gene) TYMS
TYMS {u} (Gene) is bound by {v} (Compound) Trimethoprim
Sapropterin {u} (Compound) downregulates {v} (Gene) RNH1
RNH1 {u} (Gene) regulates {v} (Gene) TYMS
TYMS {u} (Gene) is bound by {v} (Compound) Trimethoprim
Sapropterin {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Pyrimethamine
Pyrimethamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trimethoprim
Sapropterin (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Trimethoprim (Compound)
Sapropterin (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Montelukast (Compound) and Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim
Sapropterin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Trimethobenzamide (Compound) and Trimethobenzamide (Compound) resembles Trimethoprim (Compound)
Sapropterin (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Trimetrexate (Compound) and Trimetrexate (Compound) resembles Trimethoprim (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Dapsone (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim
Sapropterin (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Treprostinil (Compound) and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim
Sapropterin (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Trimethoprim (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) regulates TYMS (Gene) and TYMS (Gene) is bound by Trimethoprim (Compound)
Sapropterin (Compound) downregulates RNH1 (Gene) and RNH1 (Gene) regulates TYMS (Gene) and TYMS (Gene) is bound by Trimethoprim (Compound)
Sapropterin (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Pyrimethamine (Compound) and Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Trimethoprim