DDInter1826 DDInter1335
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. In November 2006, omacetaxine mepesuccinate, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, omacetaxine mepesuccinate was marketed under the brand name Synribo and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
Tolazamide {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) downregulates {v} (Gene) IER3
IER3 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Tolazamide {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is regulated by {v} (Gene) HIST1H2BK
HIST1H2BK {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) downregulates {v} (Gene) IER3
IER3 {u} (Gene) is regulated by {v} (Gene) DUSP6
DUSP6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} (Compound) downregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) resembles {v} (Compound) Sulfacetamide
Sulfacetamide {u} (Compound) resembles {v} (Compound) Dapsone
Dapsone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Omacetaxine mepesuccinate
Tolazamide {u} (Compound) resembles {v} (Compound) Tolbutamide
Tolbutamide {u} (Compound) upregulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) regulates {v} (Gene) ATF6
ATF6 {u} (Gene) is upregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide {u} (Compound) resembles {v} (Compound) Glipizide
Glipizide {u} (Compound) downregulates {v} (Gene) NPDC1
NPDC1 {u} (Gene) is downregulated by {v} (Compound) Omacetaxine mepesuccinate
Tolazamide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Tolazamide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is regulated by HIST1H2BK (Gene) and HIST1H2BK (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) downregulates IER3 (Gene) and IER3 (Gene) is regulated by DUSP6 (Gene) and DUSP6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide (Compound) downregulates JMJD6 (Gene) and JMJD6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) resembles Sulfacetamide (Compound) and Sulfacetamide (Compound) resembles Dapsone (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Tolazamide (Compound) resembles Tolbutamide (Compound) and Tolbutamide (Compound) upregulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) regulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Tolazamide (Compound) resembles Glipizide (Compound) and Glipizide (Compound) downregulates NPDC1 (Gene) and NPDC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)