DDInter336 DDInter908
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties.
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Bimatoprost
Bimatoprost {u} (Compound) resembles {v} (Compound) Iloprost
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Tadalafil
Tadalafil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Iloprost
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Trandolapril
Trandolapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Celecoxib {u} (Compound) causes {v} (Side Effect) Eye disorder
Eye disorder {u} (Side Effect) is caused by {v} (Compound) Escitalopram
Escitalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Celecoxib {u} (Compound) causes {v} (Side Effect) Nasopharyngitis
Nasopharyngitis {u} (Side Effect) is caused by {v} (Compound) Ponatinib
Ponatinib {u} may lead to a major life threatening interaction when taken with {v} Iloprost
Celecoxib {u} (Compound) causes {v} (Side Effect) Hypercholesterolaemia
Hypercholesterolaemia {u} (Side Effect) is caused by {v} (Compound) Tizanidine
Tizanidine {u} may lead to a major life threatening interaction when taken with {v} Iloprost
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Tafluprost
Tafluprost {u} (Compound) resembles {v} (Compound) Iloprost
Celecoxib {u} (Compound) palliates {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) PDE4D
PDE4D {u} (Gene) is bound by {v} (Compound) Iloprost
Celecoxib {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloprost
Celecoxib {u} (Compound) palliates {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is associated with {v} (Gene) PDE4D
PDE4D {u} (Gene) is bound by {v} (Compound) Iloprost
Celecoxib (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Bimatoprost (Compound) and Bimatoprost (Compound) resembles Iloprost (Compound)
Celecoxib (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Tadalafil (Compound) and Tadalafil may cause a minor interaction that can limit clinical effects when taken with Iloprost
Celecoxib (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Trandolapril (Compound) and Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Celecoxib (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Escitalopram (Compound) and Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Celecoxib (Compound) causes Nasopharyngitis (Side Effect) and Nasopharyngitis (Side Effect) is caused by Ponatinib (Compound) and Ponatinib may lead to a major life threatening interaction when taken with Iloprost
Celecoxib (Compound) causes Hypercholesterolaemia (Side Effect) and Hypercholesterolaemia (Side Effect) is caused by Tizanidine (Compound) and Tizanidine may lead to a major life threatening interaction when taken with Iloprost
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Tafluprost (Compound) and Tafluprost (Compound) resembles Iloprost (Compound)
Celecoxib (Compound) palliates colon cancer (Disease) and colon cancer (Disease) downregulates PDE4D (Gene) and PDE4D (Gene) is bound by Iloprost (Compound)
Celecoxib (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Celecoxib (Compound) palliates prostate cancer (Disease) and prostate cancer (Disease) is associated with PDE4D (Gene) and PDE4D (Gene) is bound by Iloprost (Compound)