DDInter1075 DDInter278
Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Liotrix {u} (Compound) resembles {v} (Compound) Liothyronine
Liotrix {u} (Compound) resembles {v} (Compound) Levothyroxine
Liotrix {u} (Compound) treats {v} (Disease) hypothyroidism
Liotrix {u} (Compound) binds {v} (Gene) SLCO1B1
Liotrix {u} (Compound) upregulates {v} (Gene) ABCC5
Liotrix {u} (Compound) downregulates {v} (Gene) CDC20
Liotrix {u} (Compound) causes {v} (Side Effect) Constipation
Liotrix {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Liotrix {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Albiglutide
Liotrix {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Liotrix (Compound) resembles Liothyronine (Compound)
Liotrix (Compound) resembles Levothyroxine (Compound)
Liotrix (Compound) treats hypothyroidism (Disease)
Liotrix (Compound) binds SLCO1B1 (Gene)
Liotrix (Compound) upregulates ABCC5 (Gene)
Liotrix (Compound) downregulates CDC20 (Gene)
Liotrix (Compound) causes Constipation (Side Effect)
Liotrix may cause a minor interaction that can limit clinical effects when taken with Sucralfate
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide