DDInter78 DDInter1376
Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Amitriptyline {u} (Compound) resembles {v} (Compound) Pheniramine
Amitriptyline {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Amitriptyline {u} (Compound) treats {v} (Disease) migraine
Amitriptyline {u} (Compound) binds {v} (Gene) KCNQ2
Amitriptyline {u} (Compound) upregulates {v} (Gene) PPP1R13B
Amitriptyline {u} (Compound) palliates {v} (Disease) multiple sclerosis
Amitriptyline {u} (Compound) downregulates {v} (Gene) NUP85
Amitriptyline {u} (Compound) causes {v} (Side Effect) Tinnitus
Amitriptyline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Amitriptyline (Compound) resembles Pheniramine (Compound)
Amitriptyline (Compound) resembles Bromodiphenhydramine (Compound)
Amitriptyline (Compound) treats migraine (Disease)
Amitriptyline (Compound) binds KCNQ2 (Gene)
Amitriptyline (Compound) upregulates PPP1R13B (Gene)
Amitriptyline (Compound) palliates multiple sclerosis (Disease)
Amitriptyline (Compound) downregulates NUP85 (Gene)
Amitriptyline (Compound) causes Tinnitus (Side Effect)
Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole