DDInter1756 DDInter1376
Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Telavancin {u} (Compound) resembles {v} (Compound) Oritavancin
Telavancin {u} (Compound) resembles {v} (Compound) Vancomycin
Telavancin {u} (Compound) is included by {v} (Pharmacologic Class) Lipoglycopeptides
Telavancin {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Telavancin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Telavancin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Castor oil
Telavancin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Telavancin {u} may lead to a major life threatening interaction when taken with {v} Vemurafenib
Telavancin {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Telavancin (Compound) resembles Oritavancin (Compound)
Telavancin (Compound) resembles Vancomycin (Compound)
Telavancin (Compound) is included by Lipoglycopeptides (Pharmacologic Class)
Telavancin (Compound) causes Abdominal discomfort (Side Effect)
Telavancin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Telavancin may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Telavancin may lead to a major life threatening interaction when taken with Vemurafenib
Telavancin may lead to a major life threatening interaction when taken with Dolasetron