DDInter458 DDInter1088
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxylate] and [haloperidol]. Due to pharmacological properties, loperamide has been misused and abused to self-manage opioid withdrawal symptoms and to induce euphoria.[A251610, A251625] However, loperamide is associated with a risk for experiencing a range of adverse effects, often life-threatening, if taking for non-therapeutic reasons or at doses higher than the recommended dose.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Loperamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Loperamide
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is downregulated by {v} (Compound) Loperamide
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Loperamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fentanyl
Fentanyl {u} (Compound) resembles {v} (Compound) Loperamide
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loperamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) NPC1
NPC1 {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Loperamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is upregulated by {v} (Compound) Clotrimazole
Clotrimazole {u} (Compound) resembles {v} (Compound) Loperamide
Cyclosporine {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is regulated by {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Loperamide
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Loperamide (Compound)
Cyclosporine (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Loperamide (Compound)
Cyclosporine (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is downregulated by Loperamide (Compound)
Cyclosporine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loperamide (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fentanyl (Compound) and Fentanyl (Compound) resembles Loperamide (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Cyclosporine (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Tamoxifen (Compound) and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Cyclosporine (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Loperamide (Compound)
Cyclosporine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Clotrimazole (Compound) and Clotrimazole (Compound) resembles Loperamide (Compound)
Cyclosporine (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is regulated by LIPA (Gene) and LIPA (Gene) is upregulated by Loperamide (Compound)