DDInter543 DDInter1651
Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. Dicyclomine was granted FDA approval on 11 May 1950.
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system . Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
Dicyclomine {u} (Compound) binds {v} (Gene) CHRM3
Dicyclomine {u} (Compound) causes {v} (Side Effect) Transient global amnesia
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trichlormethiazide
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Dicyclomine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arbutamine
Dicyclomine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tacrine
Dicyclomine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Dicyclomine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Dicyclomine (Compound) binds CHRM3 (Gene)
Dicyclomine (Compound) causes Transient global amnesia (Side Effect)
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Digoxin
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Arbutamine
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Tacrine
Dicyclomine may lead to a major life threatening interaction when taken with Potassium chloride
Dicyclomine may lead to a major life threatening interaction when taken with Zonisamide