DDInter1008 DDInter904
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) causes {v} (Side Effect) Chills
Chills {u} (Side Effect) is caused by {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) resembles {v} (Compound) Posaconazole
Posaconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Idarubicin
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Idarubicin
Ketoconazole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) upregulates {v} (Gene) ABHD4
ABHD4 {u} (Gene) is regulated by {v} (Gene) PSMB9
PSMB9 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) upregulates {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Doxorubicin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Ketoconazole {u} (Compound) upregulates {v} (Gene) HMGCS1
HMGCS1 {u} (Gene) regulates {v} (Gene) FUT1
FUT1 {u} (Gene) is upregulated by {v} (Compound) Idarubicin
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Ketoconazole (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is upregulated by Idarubicin (Compound)
Ketoconazole (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is downregulated by Idarubicin (Compound)
Ketoconazole (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Idarubicin (Compound)
Ketoconazole (Compound) resembles Posaconazole (Compound) and Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Ketoconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Idarubicin
Ketoconazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Ketoconazole (Compound) upregulates ABHD4 (Gene) and ABHD4 (Gene) is regulated by PSMB9 (Gene) and PSMB9 (Gene) is upregulated by Idarubicin (Compound)
Ketoconazole (Compound) upregulates ALDOC (Gene) and ALDOC (Gene) is upregulated by Doxorubicin (Compound) and Doxorubicin (Compound) resembles Idarubicin (Compound)
Ketoconazole (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) regulates FUT1 (Gene) and FUT1 (Gene) is upregulated by Idarubicin (Compound)