DDInter1759 DDInter1344
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papaver somniferum_, which is more known as poppies. This plant is an integrant of the Papaveraceae family, and it is characterized by solitary leaves and capsulated fruits. Therefore, opium is a sticky brown resin obtained by collecting and drying the latex that exudes from the poppy pods. Once extracted, opium contains two main groups of alkaloids; the psychoactive constituents which are in the category of phenanthrenes and alkaloids that have no central nervous system effect in the category of isoquinolines. Morphine is the most prevalent and principal alkaloid in opium, and it is responsible for most of the harmful effects of opium. Opium has gradually been superseded by a variety of synthetic opioids and general anesthetics. Some of the isolated derivatives of opium are morphine, noscapine, strychnine, veratrine, colchicine, codeine, and quinine. Opium is a prohibited drug of abuse in most countries, but the illegal production of this drug and its derivatives keeps being registered. There is some legal production of opium in different countries for the obtention of alkaloids by extraction.
Telmisartan {u} (Compound) resembles {v} (Compound) Olmesartan
Olmesartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) resembles {v} (Compound) Olmesartan
Olmesartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) resembles {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Azilsartan medoxomil
Azilsartan medoxomil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) resembles {v} (Compound) Azilsartan medoxomil
Azilsartan medoxomil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Methdilazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Nicardipine
Nicardipine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) resembles {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Olmesartan
Olmesartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Venlafaxine
Venlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) treats {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is palliated by {v} (Compound) Isosorbide mononitrate
Isosorbide mononitrate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) binds {v} (Gene) PPARG
PPARG {u} (Gene) is upregulated by {v} (Compound) Thioridazine
Thioridazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan {u} (Compound) is included by {v} (Pharmacologic Class) Angiotensin 2 Receptor Antagonists
Angiotensin 2 Receptor Antagonists {u} (Pharmacologic Class) includes {v} (Compound) Eprosartan
Eprosartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Opium
Telmisartan (Compound) resembles Olmesartan (Compound) and Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) resembles Olmesartan (Compound) and Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) resembles Candesartan (Compound) and Candesartan (Compound) resembles Azilsartan medoxomil (Compound) and Azilsartan medoxomil may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) resembles Azilsartan medoxomil (Compound) and Azilsartan medoxomil may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) resembles Candesartan (Compound) and Candesartan (Compound) resembles Olmesartan (Compound) and Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Venlafaxine (Compound) and Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is palliated by Isosorbide mononitrate (Compound) and Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) binds PPARG (Gene) and PPARG (Gene) is upregulated by Thioridazine (Compound) and Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Telmisartan (Compound) is included by Angiotensin 2 Receptor Antagonists (Pharmacologic Class) and Angiotensin 2 Receptor Antagonists (Pharmacologic Class) includes Eprosartan (Compound) and Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Opium