DDInter1666 DDInter1233
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614]. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Sildenafil {u} (Compound) causes {v} (Side Effect) Unspecified disorder of skin and subcutaneous tissue
Unspecified disorder of skin and subcutaneous tissue {u} (Side Effect) is caused by {v} (Compound) Mitotane
Sildenafil {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Sildenafil {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) resembles {v} (Compound) Mitotane
Sildenafil {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is regulated by {v} (Gene) SERPINA6
SERPINA6 {u} (Gene) is bound by {v} (Compound) Mitotane
Sildenafil {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is regulated by {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Sildenafil {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) interacts with {v} (Gene) FDX1
FDX1 {u} (Gene) is bound by {v} (Compound) Mitotane
Sildenafil {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) regulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Sildenafil {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is regulated by {v} (Gene) ARNT2
ARNT2 {u} (Gene) is downregulated by {v} (Compound) Mitotane
Sildenafil {u} (Compound) downregulates {v} (Gene) IGFBP2
IGFBP2 {u} (Gene) regulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Mitotane
Sildenafil {u} (Compound) binds {v} (Gene) ABCC5
ABCC5 {u} (Gene) is regulated by {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Mitotane
Sildenafil (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Mitotane (Compound)
Sildenafil (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Sildenafil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Carbinoxamine (Compound) and Carbinoxamine (Compound) resembles Mitotane (Compound)
Sildenafil (Compound) downregulates CYCS (Gene) and CYCS (Gene) is regulated by SERPINA6 (Gene) and SERPINA6 (Gene) is bound by Mitotane (Compound)
Sildenafil (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is regulated by ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Mitotane (Compound)
Sildenafil (Compound) downregulates CYCS (Gene) and CYCS (Gene) interacts with FDX1 (Gene) and FDX1 (Gene) is bound by Mitotane (Compound)
Sildenafil (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) regulates ADGRE5 (Gene) and ADGRE5 (Gene) is upregulated by Mitotane (Compound)
Sildenafil (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is regulated by ARNT2 (Gene) and ARNT2 (Gene) is downregulated by Mitotane (Compound)
Sildenafil (Compound) downregulates IGFBP2 (Gene) and IGFBP2 (Gene) regulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Mitotane (Compound)
Sildenafil (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is regulated by FAM69A (Gene) and FAM69A (Gene) is downregulated by Mitotane (Compound)