DDInter1404 DDInter458
Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia cells have low levels of this enzyme and depend on exogenous sources. Therefore, the use of pegaspargase results in leukemic cell death.[A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic leukemia (ALL). However, using L-asparaginase derived from _Escherich
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ardeparin
Ardeparin {u} (Compound) causes {v} (Side Effect) Malaise
Malaise {u} (Side Effect) is caused by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meloxicam
Meloxicam {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Trovafloxacin
Trovafloxacin {u} (Compound) binds {v} (Gene) TOP2A
TOP2A {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meloxicam
Meloxicam {u} (Compound) palliates {v} (Disease) systemic lupus erythematosus
systemic lupus erythematosus {u} (Disease) is treated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Clofarabine {u} (Compound) upregulates {v} (Gene) SLC1A4
SLC1A4 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfadoxine
Sulfadoxine {u} (Compound) downregulates {v} (Gene) CD320
CD320 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Budesonide {u} (Compound) downregulates {v} (Gene) SQSTM1
SQSTM1 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methylprednisolone
Methylprednisolone {u} (Compound) treats {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Budesonide {u} (Compound) upregulates {v} (Gene) HSPB1
HSPB1 {u} (Gene) is downregulated by {v} (Compound) Cyclosporine
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Riluzole
Riluzole {u} (Compound) binds {v} (Gene) SLC7A11
SLC7A11 {u} (Gene) is upregulated by {v} (Compound) Cyclosporine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ardeparin and Ardeparin (Compound) causes Malaise (Side Effect) and Malaise (Side Effect) is caused by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Trovafloxacin and Trovafloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxicam (Compound) palliates systemic lupus erythematosus (Disease) and systemic lupus erythematosus (Disease) is treated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) upregulates SLC1A4 (Gene) and SLC1A4 (Gene) is upregulated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Sulfadoxine and Sulfadoxine (Compound) downregulates CD320 (Gene) and CD320 (Gene) is downregulated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) downregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) treats rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) upregulates HSPB1 (Gene) and HSPB1 (Gene) is downregulated by Cyclosporine (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Riluzole and Riluzole (Compound) binds SLC7A11 (Gene) and SLC7A11 (Gene) is upregulated by Cyclosporine (Compound)