DDInter385 DDInter624
In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Cisapride {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Efavirenz
Cisapride {u} (Compound) resembles {v} (Compound) Trimethobenzamide
Trimethobenzamide {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Iloperidone {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Efavirenz
Cisapride {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Cisapride {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) covaries with {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Cisapride {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Efavirenz
Cisapride {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) regulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Iloperidone {u} (Compound) causes {v} (Side Effect) Vision blurred
Vision blurred {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Cisapride {u} (Compound) resembles {v} (Compound) Gefitinib
Gefitinib {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Cisapride (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)
Cisapride (Compound) resembles Metoclopramide (Compound) and Metoclopramide (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Efavirenz (Compound)
Cisapride (Compound) resembles Trimethobenzamide (Compound) and Trimethobenzamide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Efavirenz (Compound)
Cisapride may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Efavirenz (Compound)
Cisapride (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Cisapride (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) covaries with CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)
Cisapride (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Efavirenz (Compound)
Cisapride (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) regulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Cisapride may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Efavirenz (Compound)
Cisapride (Compound) resembles Gefitinib (Compound) and Gefitinib (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)