DDInter675 DDInter1376
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Esmolol {u} (Compound) resembles {v} (Compound) Metipranolol
Esmolol {u} (Compound) resembles {v} (Compound) Acebutolol
Esmolol {u} (Compound) treats {v} (Disease) hypertension
Esmolol {u} (Compound) binds {v} (Gene) ADRB1
Esmolol {u} (Compound) upregulates {v} (Gene) CAB39
Esmolol {u} (Compound) downregulates {v} (Gene) JMJD6
Esmolol {u} (Compound) causes {v} (Side Effect) Hyperhidrosis
Esmolol (Compound) resembles Metipranolol (Compound)
Esmolol (Compound) resembles Acebutolol (Compound)
Esmolol (Compound) treats hypertension (Disease)
Esmolol (Compound) binds ADRB1 (Gene)
Esmolol (Compound) upregulates CAB39 (Gene)
Esmolol (Compound) downregulates JMJD6 (Gene)
Esmolol (Compound) causes Hyperhidrosis (Side Effect)