DDInter1582 DDInter1376
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. The FDA withdrew its approval for the use of all oral dosage form drug products containing more than 1 mg of reserpine.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Reserpine {u} (Compound) resembles {v} (Compound) Rescinnamine
Reserpine {u} (Compound) treats {v} (Disease) hypertension
Reserpine {u} (Compound) binds {v} (Gene) ABCC2
Reserpine {u} (Compound) upregulates {v} (Gene) STX4
Reserpine {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Sympathetic Activity
Reserpine {u} (Compound) downregulates {v} (Gene) TFDP1
Reserpine {u} (Compound) causes {v} (Side Effect) Parkinsonism
Reserpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ephedrine
Reserpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Reserpine {u} may lead to a major life threatening interaction when taken with {v} Cocaine
Reserpine (Compound) resembles Rescinnamine (Compound)
Reserpine (Compound) treats hypertension (Disease)
Reserpine (Compound) binds ABCC2 (Gene)
Reserpine (Compound) upregulates STX4 (Gene)
Reserpine (Compound) is included by Decreased Sympathetic Activity (Pharmacologic Class)
Reserpine (Compound) downregulates TFDP1 (Gene)
Reserpine (Compound) causes Parkinsonism (Side Effect)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Reserpine may lead to a major life threatening interaction when taken with Cocaine