DDInter350 DDInter742
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Chlorambucil {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Floxuridine
Chlorambucil {u} (Compound) downregulates {v} (Gene) CENPA
CENPA {u} (Gene) is downregulated by {v} (Compound) Floxuridine
Chlorambucil {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Floxuridine
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Floxuridine
Chlorambucil {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is regulated by {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Floxuridine
Chlorambucil {u} (Compound) upregulates {v} (Gene) PIDD1
PIDD1 {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Floxuridine
Chlorambucil {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Trifluridine
Trifluridine {u} (Compound) resembles {v} (Compound) Floxuridine
Chlorambucil {u} (Compound) upregulates {v} (Gene) TRIM22
TRIM22 {u} (Gene) is regulated by {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Floxuridine
Chlorambucil {u} (Compound) downregulates {v} (Gene) CENPA
CENPA {u} (Gene) is downregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Floxuridine
Chlorambucil {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Trifluridine
Trifluridine {u} (Compound) resembles {v} (Compound) Floxuridine
Chlorambucil (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Floxuridine (Compound)
Chlorambucil (Compound) downregulates CENPA (Gene) and CENPA (Gene) is downregulated by Floxuridine (Compound)
Chlorambucil (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Floxuridine (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine
Chlorambucil (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is regulated by PLK1 (Gene) and PLK1 (Gene) is downregulated by Floxuridine (Compound)
Chlorambucil (Compound) upregulates PIDD1 (Gene) and PIDD1 (Gene) is upregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Floxuridine
Chlorambucil (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Trifluridine (Compound) and Trifluridine (Compound) resembles Floxuridine (Compound)
Chlorambucil (Compound) upregulates TRIM22 (Gene) and TRIM22 (Gene) is regulated by CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Floxuridine (Compound)
Chlorambucil (Compound) downregulates CENPA (Gene) and CENPA (Gene) is downregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Floxuridine
Chlorambucil (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Trifluridine (Compound) and Trifluridine (Compound) resembles Floxuridine (Compound)