DDInter458 DDInter1553
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TM9SF2
TM9SF2 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nightmare
Nightmare {u} (Side Effect) is caused by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trazodone
Trazodone {u} (Compound) resembles {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) downregulates {v} (Gene) RGS2
RGS2 {u} (Gene) is regulated by {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) upregulates {v} (Gene) TM9SF2
TM9SF2 {u} (Gene) regulates {v} (Gene) PTPN6
PTPN6 {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) regulates {v} (Gene) FAM63A
FAM63A {u} (Gene) is upregulated by {v} (Compound) Quetiapine
Cyclosporine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Nefazodone {u} (Compound) resembles {v} (Compound) Quetiapine
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Quetiapine (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Quetiapine (Compound)
Cyclosporine (Compound) upregulates TM9SF2 (Gene) and TM9SF2 (Gene) is downregulated by Quetiapine (Compound)
Cyclosporine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is downregulated by Quetiapine (Compound)
Cyclosporine (Compound) causes Nightmare (Side Effect) and Nightmare (Side Effect) is caused by Quetiapine (Compound)
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trazodone (Compound) and Trazodone (Compound) resembles Quetiapine (Compound)
Cyclosporine (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is regulated by HTR2C (Gene) and HTR2C (Gene) is bound by Quetiapine (Compound)
Cyclosporine (Compound) upregulates TM9SF2 (Gene) and TM9SF2 (Gene) regulates PTPN6 (Gene) and PTPN6 (Gene) is upregulated by Quetiapine (Compound)
Cyclosporine (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) regulates FAM63A (Gene) and FAM63A (Gene) is upregulated by Quetiapine (Compound)
Cyclosporine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Nefazodone (Compound) and Nefazodone (Compound) resembles Quetiapine (Compound)