DDInter1055 DDInter1523
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Levofloxacin {u} (Compound) upregulates {v} (Gene) CPVL
CPVL {u} (Gene) is regulated by {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Probucol
Levofloxacin {u} (Compound) downregulates {v} (Gene) MMP2
MMP2 {u} (Gene) regulates {v} (Gene) CES1
CES1 {u} (Gene) is bound by {v} (Compound) Probucol
Levofloxacin {u} (Compound) upregulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Quinine
Quinine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Levofloxacin {u} (Compound) downregulates {v} (Gene) MMP2
MMP2 {u} (Gene) is upregulated by {v} (Compound) Granisetron
Granisetron {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Levofloxacin {u} (Compound) downregulates {v} (Gene) PRKACA
PRKACA {u} (Gene) interacts with {v} (Gene) ABCA1
ABCA1 {u} (Gene) is bound by {v} (Compound) Probucol
Levofloxacin {u} (Compound) upregulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Levofloxacin {u} (Compound) downregulates {v} (Gene) PAPD7
PAPD7 {u} (Gene) regulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Probucol
Levofloxacin {u} (Compound) downregulates {v} (Gene) PAPD7
PAPD7 {u} (Gene) is downregulated by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Levofloxacin {u} (Compound) downregulates {v} (Gene) PRKACA
PRKACA {u} (Gene) is upregulated by {v} (Compound) Bisacodyl
Bisacodyl {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Probucol
Levofloxacin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Probucol
Levofloxacin (Compound) upregulates CPVL (Gene) and CPVL (Gene) is regulated by CES1 (Gene) and CES1 (Gene) is bound by Probucol (Compound)
Levofloxacin (Compound) downregulates MMP2 (Gene) and MMP2 (Gene) regulates CES1 (Gene) and CES1 (Gene) is bound by Probucol (Compound)
Levofloxacin (Compound) upregulates CPVL (Gene) and CPVL (Gene) is upregulated by Quinine (Compound) and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Levofloxacin (Compound) downregulates MMP2 (Gene) and MMP2 (Gene) is upregulated by Granisetron (Compound) and Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Levofloxacin (Compound) downregulates PRKACA (Gene) and PRKACA (Gene) interacts with ABCA1 (Gene) and ABCA1 (Gene) is bound by Probucol (Compound)
Levofloxacin (Compound) upregulates CPVL (Gene) and CPVL (Gene) is upregulated by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Levofloxacin (Compound) downregulates PAPD7 (Gene) and PAPD7 (Gene) regulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Probucol (Compound)
Levofloxacin (Compound) downregulates PAPD7 (Gene) and PAPD7 (Gene) is downregulated by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Levofloxacin (Compound) downregulates PRKACA (Gene) and PRKACA (Gene) is upregulated by Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Probucol
Levofloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol