DDInter743 DDInter548
Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Diethylstilbestrol
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Dienestrol
Dienestrol {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Fludrocortisone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ritodrine
Ritodrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Diethylstilbestrol
Fluconazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diethylstilbestrol
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexamethasone
Dexamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ritodrine
Ritodrine {u} (Compound) resembles {v} (Compound) Diethylstilbestrol
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Fluconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Diethylstilbestrol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine (Compound) resembles Dienestrol (Compound) and Dienestrol (Compound) resembles Diethylstilbestrol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Fluconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Tamoxifen (Compound) and Tamoxifen (Compound) resembles Diethylstilbestrol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) resembles Diethylstilbestrol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Diethylstilbestrol (Compound)
Fluconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diethylstilbestrol (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Ritodrine and Ritodrine (Compound) resembles Diethylstilbestrol (Compound)