DDInter1768 DDInter1435
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068] Terbinafine hydrochloride was granted FDA approval on 30 December 1992.
Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue.[A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients. While surgical resection is a current standard of care for tenosynovial giant cell tumor, there are tumor types where surgeries are deemed clinically ineffective with a high risk of lifetime recurrence. Pexidartinib works by blocking the immune responses that are activated in tenosynovial giant cell tumors. In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT. Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.
Terbinafine {u} (Compound) resembles {v} (Compound) Naphazoline
Terbinafine {u} (Compound) resembles {v} (Compound) Butenafine
Terbinafine {u} (Compound) binds {v} (Gene) CYP3A4
Terbinafine {u} (Compound) upregulates {v} (Gene) NUDT3
Terbinafine {u} (Compound) is included by {v} (Pharmacologic Class) Allylamine
Terbinafine {u} (Compound) downregulates {v} (Gene) HACD3
Terbinafine {u} (Compound) causes {v} (Side Effect) Hepatic function abnormal
Terbinafine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Donepezil
Terbinafine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Terbinafine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loratadine
Terbinafine (Compound) resembles Naphazoline (Compound)
Terbinafine (Compound) resembles Butenafine (Compound)
Terbinafine (Compound) binds CYP3A4 (Gene)
Terbinafine (Compound) upregulates NUDT3 (Gene)
Terbinafine (Compound) is included by Allylamine (Pharmacologic Class)
Terbinafine (Compound) downregulates HACD3 (Gene)
Terbinafine (Compound) causes Hepatic function abnormal (Side Effect)
Terbinafine may cause a minor interaction that can limit clinical effects when taken with Donepezil
Terbinafine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Loratadine