DDInter1662 DDInter856
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Sertraline {u} (Compound) binds {v} (Gene) CYP3A4
Sertraline {u} (Compound) upregulates {v} (Gene) CYP51A1
Sertraline {u} (Compound) palliates {v} (Disease) schizophrenia
Sertraline {u} (Compound) downregulates {v} (Gene) MRPL19
Sertraline {u} (Compound) causes {v} (Side Effect) Anaphylactic shock
Sertraline (Compound) resembles Maprotiline (Compound)
Sertraline (Compound) binds CYP3A4 (Gene)
Sertraline (Compound) upregulates CYP51A1 (Gene)
Sertraline (Compound) palliates schizophrenia (Disease)
Sertraline (Compound) downregulates MRPL19 (Gene)
Sertraline (Compound) causes Anaphylactic shock (Side Effect)