DDInter1202 DDInter1658
Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Metronidazole {u} (Compound) resembles {v} (Compound) Tinidazole
Metronidazole {u} (Compound) binds {v} (Gene) CYP2C8
Metronidazole {u} (Compound) upregulates {v} (Gene) ZNF586
Metronidazole {u} (Compound) is included by {v} (Pharmacologic Class) Nitroimidazoles
Metronidazole {u} (Compound) causes {v} (Side Effect) Loss of libido
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atomoxetine
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetrabenazine
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolate mofetil
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telbivudine
Metronidazole {u} may lead to a major life threatening interaction when taken with {v} Amprenavir
Metronidazole (Compound) resembles Tinidazole (Compound)
Metronidazole (Compound) binds CYP2C8 (Gene)
Metronidazole (Compound) upregulates ZNF586 (Gene)
Metronidazole (Compound) is included by Nitroimidazoles (Pharmacologic Class)
Metronidazole (Compound) causes Loss of libido (Side Effect)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Atomoxetine
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tetrabenazine
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine
Metronidazole may lead to a major life threatening interaction when taken with Amprenavir