DDInter1853 DDInter991
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. The first isotretinoin-containing product was FDA approved on 7 May 1982.
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Tretinoin {u} (Compound) treats {v} (Disease) peripheral nervous system neoplasm
peripheral nervous system neoplasm {u} (Disease) is treated by {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) binds {v} (Gene) RXRG
RXRG {u} (Gene) is bound by {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) upregulates {v} (Gene) CES1
CES1 {u} (Gene) is upregulated by {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) is included by {v} (Pharmacologic Class) Retinoids
Retinoids {u} (Pharmacologic Class) includes {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) causes {v} (Side Effect) Anger
Anger {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Tretinoin {u} (Compound) resembles {v} (Compound) Vitamin A
Vitamin A {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Isotretinoin
Tretinoin (Compound) resembles Isotretinoin (Compound)
Tretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Isotretinoin (Compound)
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Tretinoin (Compound) treats peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is treated by Isotretinoin (Compound)
Tretinoin (Compound) binds RXRG (Gene) and RXRG (Gene) is bound by Isotretinoin (Compound)
Tretinoin (Compound) upregulates CES1 (Gene) and CES1 (Gene) is upregulated by Isotretinoin (Compound)
Tretinoin (Compound) is included by Retinoids (Pharmacologic Class) and Retinoids (Pharmacologic Class) includes Isotretinoin (Compound)
Tretinoin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Isotretinoin (Compound)
Tretinoin (Compound) causes Anger (Side Effect) and Anger (Side Effect) is caused by Isotretinoin (Compound)
Tretinoin (Compound) resembles Vitamin A (Compound) and Vitamin A (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin