DDInter20 DDInter899
Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others. Acetylsalicylic acid is a very common
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Acetylsalicylic acid {u} (Compound) resembles {v} (Compound) Salicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Meclofenamic acid
Acetylsalicylic acid {u} (Compound) treats {v} (Disease) coronary artery disease
Acetylsalicylic acid {u} (Compound) binds {v} (Gene) HSPA5
Acetylsalicylic acid {u} (Compound) upregulates {v} (Gene) STX1A
Acetylsalicylic acid {u} (Compound) palliates {v} (Disease) osteoarthritis
Acetylsalicylic acid {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Acetylsalicylic acid {u} (Compound) downregulates {v} (Gene) MRPS16
Acetylsalicylic acid {u} (Compound) causes {v} (Side Effect) Chest discomfort
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Timolol
Acetylsalicylic acid (Compound) resembles Salicylic acid (Compound)
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid
Acetylsalicylic acid (Compound) treats coronary artery disease (Disease)
Acetylsalicylic acid (Compound) binds HSPA5 (Gene)
Acetylsalicylic acid (Compound) upregulates STX1A (Gene)
Acetylsalicylic acid (Compound) palliates osteoarthritis (Disease)
Acetylsalicylic acid (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class)
Acetylsalicylic acid (Compound) downregulates MRPS16 (Gene)
Acetylsalicylic acid (Compound) causes Chest discomfort (Side Effect)
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Timolol