DDInter1853 DDInter1293
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to treatment with imatinib (Gleevec), another tyrosine kinase inhibitor used as a first-line treatment for CML.
Tretinoin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) upregulates {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) is upregulated by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) downregulates {v} (Gene) BNIP3
BNIP3 {u} (Gene) is downregulated by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) upregulates {v} (Gene) LBR
LBR {u} (Gene) is downregulated by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) upregulates {v} (Gene) EPHA3
EPHA3 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Sulfamethoxazole
Sulfamethoxazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nilotinib
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ponatinib
Ponatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nilotinib
Tretinoin {u} (Compound) upregulates {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) regulates {v} (Gene) KLHL21
KLHL21 {u} (Gene) is upregulated by {v} (Compound) Nilotinib
Tretinoin {u} (Compound) upregulates {v} (Gene) ICAM1
ICAM1 {u} (Gene) is associated with {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nilotinib
Tretinoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Tretinoin (Compound) upregulates TNFAIP3 (Gene) and TNFAIP3 (Gene) is upregulated by Nilotinib (Compound)
Tretinoin (Compound) downregulates BNIP3 (Gene) and BNIP3 (Gene) is downregulated by Nilotinib (Compound)
Tretinoin (Compound) upregulates LBR (Gene) and LBR (Gene) is downregulated by Nilotinib (Compound)
Tretinoin (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Tretinoin (Compound) upregulates EPHA3 (Gene) and EPHA3 (Gene) is bound by Nilotinib (Compound) and EPHA3 (Gene) is upregulated by Nilotinib (Compound)
Tretinoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Nilotinib
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound) and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Tretinoin (Compound) upregulates TNFAIP3 (Gene) and TNFAIP3 (Gene) regulates KLHL21 (Gene) and KLHL21 (Gene) is upregulated by Nilotinib (Compound)
Tretinoin (Compound) upregulates ICAM1 (Gene) and ICAM1 (Gene) is associated with hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib (Compound)