DDInter1098 DDInter576
Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Lovastatin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) upregulates {v} (Gene) DNAJB2
DNAJB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) binds {v} (Gene) and {u} (Compound) downregulates {v} (Gene) HDAC2
HDAC2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) upregulates {v} (Gene) ARHGAP1
ARHGAP1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Lovastatin {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) regulates {v} (Gene) LAMA3
LAMA3 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Lovastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Lovastatin (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Lovastatin (Compound) upregulates DNAJB2 (Gene) and DNAJB2 (Gene) is upregulated by Disulfiram (Compound)
Lovastatin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Lovastatin (Compound) binds HDAC2 (Gene) and Lovastatin (Compound) downregulates HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Disulfiram (Compound)
Lovastatin (Compound) upregulates ARHGAP1 (Gene) and ARHGAP1 (Gene) is downregulated by Disulfiram (Compound)
Lovastatin (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Disulfiram (Compound)
Lovastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Lovastatin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)
Lovastatin (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) regulates LAMA3 (Gene) and LAMA3 (Gene) is upregulated by Disulfiram (Compound)