DDInter45 DDInter1658
A phenothiazine derivative that is used as an antipruritic.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Alimemazine {u} (Compound) resembles {v} (Compound) Acetophenazine
Alimemazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Orphenadrine
Alimemazine {u} (Compound) resembles {v} (Compound) Pheniramine
Alimemazine {u} may lead to a major life threatening interaction when taken with {v} Dextropropoxyphene
Alimemazine {u} (Compound) binds {v} (Gene) CYP3A4
Alimemazine {u} (Compound) upregulates {v} (Gene) CHEK2
Alimemazine {u} (Compound) downregulates {v} (Gene) PDHX
Alimemazine {u} (Compound) causes {v} (Side Effect) Respiratory depression
Alimemazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Magnesium hydroxide
Alimemazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Alimemazine (Compound) resembles Acetophenazine (Compound)
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine
Alimemazine (Compound) resembles Pheniramine (Compound)
Alimemazine may lead to a major life threatening interaction when taken with Dextropropoxyphene
Alimemazine (Compound) binds CYP3A4 (Gene)
Alimemazine (Compound) upregulates CHEK2 (Gene)
Alimemazine (Compound) downregulates PDHX (Gene)
Alimemazine (Compound) causes Respiratory depression (Side Effect)
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate