DDInter458 DDInter1736
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and a longer half-life which has made it a more suitable option for chronic once-daily dosing in the treatment of PAH.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tadalafil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Conjunctivitis
Conjunctivitis {u} (Side Effect) is caused by {v} (Compound) Tadalafil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tadalafil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Conjunctivitis
Conjunctivitis {u} (Side Effect) is caused by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tadalafil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Treprostinil
Treprostinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Epoprostenol
Epoprostenol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tadalafil
Cyclosporine {u} (Compound) causes {v} (Side Effect) Uterine haemorrhage
Uterine haemorrhage {u} (Side Effect) is caused by {v} (Compound) Dasatinib
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tadalafil
Cyclosporine {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) interacts with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tadalafil
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Imatinib
Imatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tadalafil
Cyclosporine {u} (Compound) downregulates {v} (Gene) MRPS2
MRPS2 {u} (Gene) is downregulated by {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Tadalafil
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tadalafil (Compound)
Cyclosporine (Compound) causes Conjunctivitis (Side Effect) and Conjunctivitis (Side Effect) is caused by Tadalafil (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Tadalafil
Cyclosporine (Compound) causes Conjunctivitis (Side Effect) and Conjunctivitis (Side Effect) is caused by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Tadalafil
Cyclosporine (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Treprostinil (Compound) and Treprostinil may cause a minor interaction that can limit clinical effects when taken with Tadalafil
Cyclosporine (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Epoprostenol (Compound) and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Tadalafil
Cyclosporine (Compound) causes Uterine haemorrhage (Side Effect) and Uterine haemorrhage (Side Effect) is caused by Dasatinib (Compound) and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Tadalafil
Cyclosporine (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) interacts with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tadalafil (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Imatinib (Compound) and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Tadalafil
Cyclosporine (Compound) downregulates MRPS2 (Gene) and MRPS2 (Gene) is downregulated by systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Tadalafil (Compound)