DDInter1619 DDInter1789
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Thalidomide
Ropinirole {u} (Compound) causes {v} (Side Effect) Myocardial ischaemia
Myocardial ischaemia {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Ropinirole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Menadione
Menadione {u} (Compound) resembles {v} (Compound) Thalidomide
Ropinirole {u} (Compound) causes {v} (Side Effect) Myocardial ischaemia
Myocardial ischaemia {u} (Side Effect) is caused by {v} (Compound) Lenalidomide
Lenalidomide {u} (Compound) resembles {v} (Compound) Thalidomide
Ropinirole {u} (Compound) causes {v} (Side Effect) Nail disorder
Nail disorder {u} (Side Effect) is caused by {v} (Compound) Saquinavir
Saquinavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Ropinirole {u} (Compound) causes {v} (Side Effect) Acne
Acne {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Ropinirole {u} (Compound) binds {v} (Gene) DRD1
DRD1 {u} (Gene) is bound by {v} (Compound) Iloperidone
Iloperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Ropinirole {u} (Compound) binds {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Trazodone
Trazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Ropinirole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Betamethasone
Betamethasone {u} may lead to a major life threatening interaction when taken with {v} Thalidomide
Ropinirole {u} (Compound) binds {v} (Gene) HTR2C
HTR2C {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Thalidomide
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Thalidomide (Compound)
Ropinirole (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Ropinirole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Menadione (Compound) and Menadione (Compound) resembles Thalidomide (Compound)
Ropinirole (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Lenalidomide (Compound) and Lenalidomide (Compound) resembles Thalidomide (Compound)
Ropinirole (Compound) causes Nail disorder (Side Effect) and Nail disorder (Side Effect) is caused by Saquinavir (Compound) and Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Ropinirole (Compound) causes Acne (Side Effect) and Acne (Side Effect) is caused by Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Ropinirole (Compound) binds DRD1 (Gene) and DRD1 (Gene) is bound by Iloperidone (Compound) and Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Ropinirole (Compound) binds HTR2C (Gene) and HTR2C (Gene) is bound by Trazodone (Compound) and Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Ropinirole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Betamethasone (Compound) and Betamethasone may lead to a major life threatening interaction when taken with Thalidomide
Ropinirole (Compound) binds HTR2C (Gene) and HTR2C (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Thalidomide (Compound)