DDInter130 DDInter1515
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review
A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955.
Atenolol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Prednisone
Atenolol {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Prednisone
Atenolol {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Atenolol {u} (Compound) resembles {v} (Compound) Bisoprolol
Bisoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Atenolol {u} (Compound) resembles {v} (Compound) Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Atenolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Prednisone
Atenolol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dexamethasone
Dexamethasone {u} (Compound) resembles {v} (Compound) Prednisone
Atenolol {u} (Compound) causes {v} (Side Effect) Tachycardia
Tachycardia {u} (Side Effect) is caused by {v} (Compound) Triamcinolone
Triamcinolone {u} (Compound) resembles {v} (Compound) Prednisone
Atenolol {u} (Compound) causes {v} (Side Effect) Erectile dysfunction
Erectile dysfunction {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Prednisone
Atenolol {u} (Compound) causes {v} (Side Effect) Alopecia
Alopecia {u} (Side Effect) is caused by {v} (Compound) Testolactone
Testolactone {u} (Compound) resembles {v} (Compound) Prednisone
Atenolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Prednisone (Compound)
Atenolol (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Prednisone (Compound)
Atenolol (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Atenolol (Compound) resembles Bisoprolol (Compound) and Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Atenolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Atenolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Prednisone
Atenolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dexamethasone (Compound) and Dexamethasone (Compound) resembles Prednisone (Compound)
Atenolol (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Triamcinolone (Compound) and Triamcinolone (Compound) resembles Prednisone (Compound)
Atenolol (Compound) causes Erectile dysfunction (Side Effect) and Erectile dysfunction (Side Effect) is caused by Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Prednisone
Atenolol (Compound) causes Alopecia (Side Effect) and Alopecia (Side Effect) is caused by Testolactone (Compound) and Testolactone (Compound) resembles Prednisone (Compound)