DDInter336 DDInter42
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label].
Celecoxib {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Alendronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Alendronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Stevens-Johnson syndrome
Stevens-Johnson syndrome {u} (Side Effect) is caused by {v} (Compound) Etidronic acid
Etidronic acid {u} (Compound) resembles {v} (Compound) Alendronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Photosensitivity
Photosensitivity {u} (Side Effect) is caused by {v} (Compound) Ranitidine
Ranitidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Alendronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Toxic epidermal necrolysis
Toxic epidermal necrolysis {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Alendronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Transaminases increased
Transaminases increased {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alendronic acid
Celecoxib {u} (Compound) causes {v} (Side Effect) Melaena
Melaena {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alendronic acid
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Histamine Phosphate
Histamine Phosphate {u} (Compound) resembles {v} (Compound) Alendronic acid
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Cimetidine
Cimetidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Alendronic acid
Celecoxib {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Flurbiprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alendronic acid
Celecoxib (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Alendronic acid (Compound)
Celecoxib (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Ibandronate (Compound) and Ibandronate (Compound) resembles Alendronic acid (Compound)
Celecoxib (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Etidronic acid (Compound) and Etidronic acid (Compound) resembles Alendronic acid (Compound)
Celecoxib (Compound) causes Photosensitivity (Side Effect) and Photosensitivity (Side Effect) is caused by Ranitidine (Compound) and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Alendronic acid
Celecoxib (Compound) causes Toxic epidermal necrolysis (Side Effect) and Toxic epidermal necrolysis (Side Effect) is caused by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Alendronic acid
Celecoxib (Compound) causes Transaminases increased (Side Effect) and Transaminases increased (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Alendronic acid
Celecoxib (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Alendronic acid
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Histamine Phosphate (Compound) and Histamine Phosphate (Compound) resembles Alendronic acid (Compound)
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Cimetidine (Compound) and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Alendronic acid
Celecoxib (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Flurbiprofen (Compound) and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Alendronic acid