DDInter1544 DDInter1085
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009, in Canada on December 7, 2011 and by the FDA on December 17, 2018.
Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Lomitapide {u} (Compound) resembles {v} (Compound) Antrafenine
Lomitapide {u} (Compound) binds {v} (Gene) CYP3A4
Lomitapide {u} (Compound) is included by {v} (Pharmacologic Class) P-Glycoprotein Inhibitors
Lomitapide {u} (Compound) causes {v} (Side Effect) Xanthoma
Lomitapide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Lomitapide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Apixaban
Lomitapide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Olaparib
Lomitapide {u} may lead to a major life threatening interaction when taken with {v} Terbinafine
Lomitapide {u} may lead to a major life threatening interaction when taken with {v} Nintedanib
Lomitapide {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fexofenadine
Lomitapide (Compound) resembles Antrafenine (Compound)
Lomitapide (Compound) binds CYP3A4 (Gene)
Lomitapide (Compound) is included by P-Glycoprotein Inhibitors (Pharmacologic Class)
Lomitapide (Compound) causes Xanthoma (Side Effect)
Lomitapide may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Apixaban
Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Lomitapide may lead to a major life threatening interaction when taken with Terbinafine
Lomitapide may lead to a major life threatening interaction when taken with Nintedanib
Lomitapide (Compound) resembles Fexofenadine (Compound) and Lomitapide may cause a moderate interaction that could exacerbate diseases when taken with Fexofenadine