DDInter130 DDInter380
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Atenolol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Cimetidine
Atenolol {u} (Compound) causes {v} (Side Effect) Block heart
Block heart {u} (Side Effect) is caused by {v} (Compound) Cimetidine
Atenolol {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Atenolol {u} (Compound) resembles {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Atenolol {u} (Compound) resembles {v} (Compound) Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Atenolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Atenolol {u} (Compound) resembles {v} (Compound) Sotalol
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cimetidine
Atenolol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Cimetidine
Atenolol {u} (Compound) causes {v} (Side Effect) Block heart
Block heart {u} (Side Effect) is caused by {v} (Compound) Dolasetron
Dolasetron {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Atenolol {u} (Compound) causes {v} (Side Effect) Psychotic disorder
Psychotic disorder {u} (Side Effect) is caused by {v} (Compound) Indomethacin
Indomethacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Atenolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)
Atenolol (Compound) causes Block heart (Side Effect) and Block heart (Side Effect) is caused by Cimetidine (Compound)
Atenolol (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Atenolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Atenolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Atenolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Atenolol (Compound) resembles Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine
Atenolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Cimetidine (Compound)
Atenolol (Compound) causes Block heart (Side Effect) and Block heart (Side Effect) is caused by Dolasetron (Compound) and Dolasetron may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Atenolol (Compound) causes Psychotic disorder (Side Effect) and Psychotic disorder (Side Effect) is caused by Indomethacin (Compound) and Indomethacin may cause a minor interaction that can limit clinical effects when taken with Cimetidine