DDInter458 DDInter1707
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) regulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Testosterone
Testosterone {u} (Compound) resembles {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Spironolactone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Gastrointestinal symptom NOS
Gastrointestinal symptom NOS {u} (Side Effect) is caused by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Spironolactone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a minor interaction that can limit clinical effects when taken with {v} Spironolactone
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Spironolactone (Compound)
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Spironolactone (Compound)
Cyclosporine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Spironolactone (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Testosterone (Compound) and Testosterone (Compound) resembles Spironolactone (Compound)
Cyclosporine (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) regulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Spironolactone (Compound)
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Testosterone (Compound) and Testosterone (Compound) resembles Spironolactone (Compound)
Cyclosporine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Testosterone (Compound) and Testosterone (Compound) resembles Spironolactone (Compound)
Cyclosporine (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Spironolactone (Compound)
Cyclosporine (Compound) causes Gastrointestinal symptom NOS (Side Effect) and Gastrointestinal symptom NOS (Side Effect) is caused by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone
Cyclosporine (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Spironolactone