DDInter757 DDInter255
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Fluorouracil {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) head and neck cancer
head and neck cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) pancreatic cancer
pancreatic cancer {u} (Disease) downregulates {v} (Gene) SLC25A4
SLC25A4 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) head and neck cancer
head and neck cancer {u} (Disease) is associated with {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) stomach cancer
stomach cancer {u} (Disease) is associated with {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) colon cancer
colon cancer {u} (Disease) downregulates {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) colon cancer
colon cancer {u} (Disease) upregulates {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) colon cancer
colon cancer {u} (Disease) upregulates {v} (Gene) NPRL3
NPRL3 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Fluorouracil {u} (Compound) treats {v} (Disease) pancreatic cancer
pancreatic cancer {u} (Disease) upregulates {v} (Gene) PLS1
PLS1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Fluorouracil (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Fluorouracil (Compound) treats head and neck cancer (Disease) and head and neck cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Fluorouracil (Compound) treats pancreatic cancer (Disease) and pancreatic cancer (Disease) downregulates SLC25A4 (Gene) and SLC25A4 (Gene) is downregulated by Busulfan (Compound)
Fluorouracil (Compound) treats head and neck cancer (Disease) and head and neck cancer (Disease) is associated with NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Busulfan (Compound)
Fluorouracil (Compound) treats colon cancer (Disease) and colon cancer (Disease) downregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Busulfan (Compound)
Fluorouracil (Compound) treats stomach cancer (Disease) and stomach cancer (Disease) is associated with MYC (Gene) and MYC (Gene) is downregulated by Busulfan (Compound)
Fluorouracil (Compound) treats colon cancer (Disease) and colon cancer (Disease) downregulates GSTM1 (Gene) and GSTM1 (Gene) is bound by Busulfan (Compound)
Fluorouracil (Compound) treats colon cancer (Disease) and colon cancer (Disease) upregulates GSTP1 (Gene) and GSTP1 (Gene) is bound by Busulfan (Compound)
Fluorouracil (Compound) treats colon cancer (Disease) and colon cancer (Disease) upregulates NPRL3 (Gene) and NPRL3 (Gene) is upregulated by Busulfan (Compound)
Fluorouracil (Compound) treats pancreatic cancer (Disease) and pancreatic cancer (Disease) upregulates PLS1 (Gene) and PLS1 (Gene) is downregulated by Busulfan (Compound)