DDInter901 DDInter1055
Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Ibutilide {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) resembles {v} (Compound) Dronedarone
Dronedarone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) resembles {v} (Compound) Sotalol
Sotalol {u} (Compound) causes {v} (Side Effect) Disorientation
Disorientation {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) binds {v} (Gene) KCNH2
KCNH2 {u} (Gene) interacts with {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) binds {v} (Gene) KCNK1
KCNK1 {u} (Gene) regulates {v} (Gene) SELL
SELL {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Ibutilide {u} (Compound) binds {v} (Gene) CACNA1C
CACNA1C {u} (Gene) regulates {v} (Gene) HTATSF1
HTATSF1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Ibutilide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Metronidazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Ibutilide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Thalidomide {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Ibutilide (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Levofloxacin (Compound)
Ibutilide (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Ibutilide (Compound) resembles Dronedarone (Compound) and Dronedarone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Ibutilide (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Ibutilide (Compound) resembles Sotalol (Compound) and Sotalol (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Levofloxacin (Compound)
Ibutilide (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) interacts with PRKACA (Gene) and PRKACA (Gene) is downregulated by Levofloxacin (Compound)
Ibutilide (Compound) binds KCNK1 (Gene) and KCNK1 (Gene) regulates SELL (Gene) and SELL (Gene) is upregulated by Levofloxacin (Compound)
Ibutilide (Compound) binds CACNA1C (Gene) and CACNA1C (Gene) regulates HTATSF1 (Gene) and HTATSF1 (Gene) is downregulated by Levofloxacin (Compound)
Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Levofloxacin (Compound)
Ibutilide may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Levofloxacin (Compound)