DDInter350 DDInter702
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Chlorambucil {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) is treated by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is downregulated by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Etoposide
Chlorambucil {u} (Compound) treats {v} (Disease) testicular cancer
testicular cancer {u} (Disease) resembles {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is treated by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) binds {v} (Gene) GSTP1
GSTP1 {u} (Gene) is associated with {v} (Disease) urinary bladder cancer
urinary bladder cancer {u} (Disease) is treated by {v} (Compound) Etoposide
Chlorambucil {u} (Compound) upregulates {v} (Gene) GPC1
GPC1 {u} (Gene) is upregulated by {v} (Compound) Podofilox
Podofilox {u} (Compound) resembles {v} (Compound) Etoposide
Chlorambucil {u} (Compound) upregulates {v} (Gene) TRIM22
TRIM22 {u} (Gene) is regulated by {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Etoposide
Chlorambucil (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Etoposide (Compound)
Chlorambucil (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is bound by Etoposide (Compound)
Chlorambucil (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Etoposide (Compound)
Chlorambucil (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Etoposide (Compound)
Chlorambucil (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Etoposide (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Etoposide
Chlorambucil (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) resembles urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Etoposide (Compound)
Chlorambucil (Compound) binds GSTP1 (Gene) and GSTP1 (Gene) is associated with urinary bladder cancer (Disease) and urinary bladder cancer (Disease) is treated by Etoposide (Compound)
Chlorambucil (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is upregulated by Podofilox (Compound) and Podofilox (Compound) resembles Etoposide (Compound)
Chlorambucil (Compound) upregulates TRIM22 (Gene) and TRIM22 (Gene) is regulated by CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Etoposide (Compound)