DDInter535 DDInter1798
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Diazoxide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Thiothixene
Diazoxide {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Diazoxide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Chlorpromazine
Chlorpromazine {u} (Compound) resembles {v} (Compound) Thiothixene
Diazoxide {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Thiothixene
Diazoxide {u} (Compound) causes {v} (Side Effect) Hyperglycaemia
Hyperglycaemia {u} (Side Effect) is caused by {v} (Compound) Zuclopenthixol
Zuclopenthixol {u} (Compound) resembles {v} (Compound) Thiothixene
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) DPH2
DPH2 {u} (Gene) is downregulated by {v} (Compound) Thiothixene
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxepin
Doxepin {u} (Compound) resembles {v} (Compound) Thiothixene
Diazoxide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) interacts with {v} (Gene) HSD17B7
HSD17B7 {u} (Gene) is upregulated by {v} (Compound) Thiothixene
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Thiothixene
Diazoxide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Thiothixene (Compound)
Diazoxide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Thiothixene (Compound)
Diazoxide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Chlorpromazine (Compound) and Chlorpromazine (Compound) resembles Thiothixene (Compound)
Diazoxide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Doxepin (Compound) and Doxepin (Compound) resembles Thiothixene (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Thiothixene (Compound)
Diazoxide (Compound) causes Hyperglycaemia (Side Effect) and Hyperglycaemia (Side Effect) is caused by Zuclopenthixol (Compound) and Zuclopenthixol (Compound) resembles Thiothixene (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates DPH2 (Gene) and DPH2 (Gene) is downregulated by Thiothixene (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin (Compound) resembles Thiothixene (Compound)
Diazoxide (Compound) binds CA1 (Gene) and CA1 (Gene) interacts with HSD17B7 (Gene) and HSD17B7 (Gene) is upregulated by Thiothixene (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Thiothixene (Compound)