DDInter1123 DDInter1224
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid. On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients and is currently marketed for this indication under the name BRONCHITOL® by Chies
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines. Minocycline was granted FDA approval on 30 June 1971.
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is associated with {v} (Gene) VEGFA
VEGFA {u} (Gene) is bound by {v} (Compound) Minocycline
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) IL1B
IL1B {u} (Gene) is bound by {v} (Compound) Minocycline
Mannitol {u} (Compound) is included by {v} (Pharmacologic Class) Increased Diuresis
Increased Diuresis {u} (Pharmacologic Class) includes {v} (Compound) Indapamide
Indapamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Spironolactone
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Acetazolamide
Acetazolamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Mannitol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Leflunomide {u} may lead to a major life threatening interaction when taken with {v} Minocycline
Mannitol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mycophenolate mofetil
Mycophenolate mofetil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minocycline
Mannitol {u} (Compound) causes {v} (Side Effect) Gastrointestinal disorder
Gastrointestinal disorder {u} (Side Effect) is caused by {v} (Compound) Nafcillin
Nafcillin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minocycline
Mannitol {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Mannitol {u} (Compound) palliates {v} (Disease) glaucoma
glaucoma {u} (Disease) is treated by {v} (Compound) Diclofenamide
Diclofenamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Minocycline
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is associated with VEGFA (Gene) and VEGFA (Gene) is bound by Minocycline (Compound)
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates IL1B (Gene) and IL1B (Gene) is bound by Minocycline (Compound)
Mannitol (Compound) is included by Increased Diuresis (Pharmacologic Class) and Increased Diuresis (Pharmacologic Class) includes Indapamide (Compound) and Indapamide may cause a minor interaction that can limit clinical effects when taken with Minocycline
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Spironolactone (Compound) and Spironolactone may cause a minor interaction that can limit clinical effects when taken with Minocycline
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Acetazolamide (Compound) and Acetazolamide may cause a minor interaction that can limit clinical effects when taken with Minocycline
Mannitol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Leflunomide (Compound) and Leflunomide may lead to a major life threatening interaction when taken with Minocycline
Mannitol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mycophenolate mofetil (Compound) and Mycophenolate mofetil may cause a moderate interaction that could exacerbate diseases when taken with Minocycline
Mannitol (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Nafcillin (Compound) and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Minocycline
Mannitol (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Indapamide (Compound) and Indapamide may cause a minor interaction that can limit clinical effects when taken with Minocycline
Mannitol (Compound) palliates glaucoma (Disease) and glaucoma (Disease) is treated by Diclofenamide (Compound) and Diclofenamide may cause a minor interaction that can limit clinical effects when taken with Minocycline