DDInter1042 DDInter1523
Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the GnRH receptor (GnRHR) and inducing downstream modulation of both gonadotropin hormone and sex steroid levels. Prolonged activation of GnRHR results in significant downregulation of sex steroid levels, which is primarily responsible for the clinical efficacy of leuprolide in diverse conditions, including advanced prostate cancer, endometriosis, and central precocious puberty.[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename
A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Probucol {u} (Compound) binds {v} (Gene) CES1
Probucol {u} (Compound) upregulates {v} (Gene) RRS1
Probucol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Probucol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaliplatin
Probucol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Encorafenib
Probucol {u} may lead to a major life threatening interaction when taken with {v} Hydroxychloroquine
Probucol {u} may lead to a major life threatening interaction when taken with {v} Toremifene
Probucol (Compound) binds CES1 (Gene)
Probucol (Compound) upregulates RRS1 (Gene)
Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Probucol may lead to a major life threatening interaction when taken with Hydroxychloroquine
Probucol may lead to a major life threatening interaction when taken with Toremifene