DDInter906 DDInter1747
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Ifosfamide {u} (Compound) treats {v} (Disease) testicular cancer
Ifosfamide {u} (Compound) binds {v} (Gene) CYP2A6
Ifosfamide {u} (Compound) upregulates {v} (Gene) UBQLN2
Ifosfamide {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Ifosfamide {u} (Compound) downregulates {v} (Gene) STUB1
Ifosfamide {u} (Compound) causes {v} (Side Effect) Palpitations
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trovafloxacin
Ifosfamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sparfloxacin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aldesleukin
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quazepam
Ifosfamide (Compound) treats testicular cancer (Disease)
Ifosfamide (Compound) binds CYP2A6 (Gene)
Ifosfamide (Compound) upregulates UBQLN2 (Gene)
Ifosfamide (Compound) is included by Alkylating Activity (Pharmacologic Class)
Ifosfamide (Compound) downregulates STUB1 (Gene)
Ifosfamide (Compound) causes Palpitations (Side Effect)
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin
Ifosfamide may cause a minor interaction that can limit clinical effects when taken with Sparfloxacin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Quazepam