DDInter458 DDInter716
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Felodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CGRRF1
CGRRF1 {u} (Gene) is upregulated by {v} (Compound) Felodipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Felodipine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Felodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CGRRF1
CGRRF1 {u} (Gene) is upregulated by {v} (Compound) Dabrafenib
Dabrafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Felodipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Felodipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Influenza like illness
Influenza like illness {u} (Side Effect) is caused by {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Felodipine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Abdominal discomfort
Abdominal discomfort {u} (Side Effect) is caused by {v} (Compound) Isradipine
Isradipine {u} (Compound) resembles {v} (Compound) Felodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) KLHDC2
KLHDC2 {u} (Gene) is upregulated by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Felodipine
Cyclosporine {u} (Compound) upregulates {v} (Gene) CGRRF1
CGRRF1 {u} (Gene) is downregulated by {v} (Compound) Idarubicin
Idarubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Felodipine
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Felodipine (Compound)
Cyclosporine (Compound) upregulates CGRRF1 (Gene) and CGRRF1 (Gene) is upregulated by Felodipine (Compound)
Cyclosporine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Felodipine (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Amlodipine (Compound) and Amlodipine (Compound) resembles Felodipine (Compound)
Cyclosporine (Compound) upregulates CGRRF1 (Gene) and CGRRF1 (Gene) is upregulated by Dabrafenib (Compound) and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Felodipine
Cyclosporine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Amlodipine (Compound) and Amlodipine (Compound) resembles Felodipine (Compound)
Cyclosporine (Compound) causes Influenza like illness (Side Effect) and Influenza like illness (Side Effect) is caused by Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Felodipine
Cyclosporine (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Isradipine (Compound) and Isradipine (Compound) resembles Felodipine (Compound)
Cyclosporine (Compound) upregulates KLHDC2 (Gene) and KLHDC2 (Gene) is upregulated by Amlodipine (Compound) and Amlodipine (Compound) resembles Felodipine (Compound)
Cyclosporine (Compound) upregulates CGRRF1 (Gene) and CGRRF1 (Gene) is downregulated by Idarubicin (Compound) and Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Felodipine