DDInter1263 DDInter576
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) downregulates {v} (Gene) FOSL1
FOSL1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) causes {v} (Side Effect) Upset stomach
Upset stomach {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) treats {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) is regulated by {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) regulates {v} (Gene) CTSL
CTSL {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) downregulates {v} (Gene) FOSL1
FOSL1 {u} (Gene) interacts with {v} (Gene) IL11
IL11 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Naltrexone {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is regulated by {v} (Gene) NFKB2
NFKB2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Naltrexone (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Disulfiram (Compound)
Naltrexone (Compound) downregulates FOSL1 (Gene) and FOSL1 (Gene) is upregulated by Disulfiram (Compound)
Naltrexone (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Disulfiram (Compound)
Naltrexone (Compound) causes Upset stomach (Side Effect) and Upset stomach (Side Effect) is caused by Disulfiram (Compound)
Naltrexone (Compound) treats alcohol dependence (Disease) and alcohol dependence (Disease) is associated with CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Disulfiram (Compound)
Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is regulated by FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Naltrexone (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) regulates CTSL (Gene) and CTSL (Gene) is upregulated by Disulfiram (Compound)
Naltrexone (Compound) downregulates FOSL1 (Gene) and FOSL1 (Gene) interacts with IL11 (Gene) and IL11 (Gene) is upregulated by Disulfiram (Compound)
Naltrexone (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is regulated by NFKB2 (Gene) and NFKB2 (Gene) is upregulated by Disulfiram (Compound)