DDInter453 DDInter1960
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Cyclizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Cyclizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cetirizine
Cyclizine {u} (Compound) resembles {v} (Compound) Trimethaphan
Cyclizine {u} (Compound) binds {v} (Gene) CYP2C9
Cyclizine {u} (Compound) upregulates {v} (Gene) STXBP1
Cyclizine {u} (Compound) downregulates {v} (Gene) TNIP1
Cyclizine {u} (Compound) causes {v} (Side Effect) Hallucinations, mixed
Cyclizine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nitroglycerin
Cyclizine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Cyclizine (Compound) resembles Ifenprodil (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Cyclizine (Compound) resembles Trimethaphan (Compound)
Cyclizine (Compound) binds CYP2C9 (Gene)
Cyclizine (Compound) upregulates STXBP1 (Gene)
Cyclizine (Compound) downregulates TNIP1 (Gene)
Cyclizine (Compound) causes Hallucinations, mixed (Side Effect)
Cyclizine may cause a minor interaction that can limit clinical effects when taken with Nitroglycerin
Cyclizine may lead to a major life threatening interaction when taken with Zonisamide