DDInter493 DDInter832
Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately causes testosterone suppression. Reduction in testosterone is important in treating men with advanced prostate cancer. Chemically, it is a synthetic linear decapeptide amide with seven unnatural amino acids, five of which are D-amino acids. FDA approved on December 24, 2008.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Degarelix {u} (Compound) resembles {v} (Compound) Nafarelin
Degarelix {u} (Compound) resembles {v} (Compound) Cetrorelix
Degarelix {u} (Compound) treats {v} (Disease) prostate cancer
Degarelix {u} (Compound) binds {v} (Gene) GNRHR
Degarelix {u} (Compound) causes {v} (Side Effect) Urticaria
Degarelix {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Degarelix {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tamoxifen
Degarelix {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Entrectinib
Degarelix {u} may lead to a major life threatening interaction when taken with {v} Amiodarone
Degarelix {u} may lead to a major life threatening interaction when taken with {v} Ivabradine
Degarelix (Compound) resembles Nafarelin (Compound)
Degarelix (Compound) resembles Cetrorelix (Compound)
Degarelix (Compound) treats prostate cancer (Disease)
Degarelix (Compound) binds GNRHR (Gene)
Degarelix (Compound) causes Urticaria (Side Effect)
Degarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen
Degarelix may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Degarelix may lead to a major life threatening interaction when taken with Amiodarone
Degarelix may lead to a major life threatening interaction when taken with Ivabradine