DDInter358 DDInter1306
Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of chloroprocaine is characterized by a short latency and duration, similar to the one observed with [lidocaine]. Chloroprocaine can be given as an injection, and is available in formulations with and without methylparaben as a preservative. Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks.[A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 for ocular surface anesthesia.
Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and Pseudomonas aeruginosa infections.
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clonidine
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Oxybuprocaine
Oxybuprocaine {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Lidocaine
Lidocaine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bosentan
Bosentan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lofexidine
Lofexidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Procaine
Procaine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sulfasalazine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Cinchocaine
Cinchocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Prilocaine
Prilocaine {u} may lead to a major life threatening interaction when taken with {v} Nitrous acid
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Nitrous acid
Chloroprocaine (Compound) resembles Procaine (Compound) and Procaine may lead to a major life threatening interaction when taken with Nitrous acid
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Chloroprocaine (Compound) resembles Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Nitrous acid
Chloroprocaine (Compound) resembles Oxybuprocaine (Compound) and Oxybuprocaine (Compound) resembles Procaine (Compound) and Procaine may lead to a major life threatening interaction when taken with Nitrous acid
Chloroprocaine (Compound) resembles Lidocaine (Compound) and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bosentan and Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Lofexidine and Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Chloroprocaine (Compound) resembles Procaine (Compound) and Procaine may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may lead to a major life threatening interaction when taken with Nitrous acid
Chloroprocaine (Compound) resembles Cinchocaine (Compound) and Cinchocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Nitrous acid
Chloroprocaine (Compound) resembles Metoclopramide (Compound) and Metoclopramide may lead to a major life threatening interaction when taken with Prilocaine and Prilocaine may lead to a major life threatening interaction when taken with Nitrous acid