DDInter222 DDInter256
Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and apoptosis of cancer cells, is thought to be the main mechanism of action of bortezomib. However, multiple mechanisms may be involved in the anticancer activity of bortezomib. Bortezomib was first synthesized in 1995. In May 2003, bortezomib became the first anticancer proteasome inhibitor that was approved by the FDA under the trade name VELCADE. Phase I, II, III, and IV clinical trials are undergoing to investigate the therapeutic efficacy of bortezomib in leukemia, myasthenia gravis, systemic
Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.[A201977,L13613] This makes butabarbital a useful drug for treating severe insomnia and pre-operative anxiety.[A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines. Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} may lead to a major life threatening interaction when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Butabarbital
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} may lead to a major life threatening interaction when taken with {v} Phenobarbital
Phenobarbital {u} (Compound) resembles {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Secobarbital
Secobarbital {u} (Compound) resembles {v} (Compound) Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Pentobarbital
Pentobarbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Bexarotene
Bexarotene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Butalbital
Butalbital {u} (Compound) resembles {v} (Compound) Butabarbital
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Butalbital and Butalbital (Compound) resembles Butabarbital (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pentobarbital and Pentobarbital (Compound) resembles Butabarbital (Compound)
Bortezomib may lead to a major life threatening interaction when taken with Phenobarbital and Phenobarbital (Compound) resembles Butabarbital (Compound)
Bortezomib (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Butabarbital (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Butalbital and Butalbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital (Compound) resembles Butabarbital (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pentobarbital and Pentobarbital (Compound) resembles Butalbital (Compound) and Butalbital (Compound) resembles Butabarbital (Compound)
Bortezomib may lead to a major life threatening interaction when taken with Phenobarbital and Phenobarbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital (Compound) resembles Butabarbital (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Secobarbital and Secobarbital (Compound) resembles Butalbital (Compound) and Butalbital (Compound) resembles Butabarbital (Compound)
Bortezomib (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Pentobarbital (Compound) and Pentobarbital (Compound) resembles Butabarbital (Compound)
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Butalbital and Butalbital (Compound) resembles Butabarbital (Compound)