DDInter596 DDInter1470
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Pimozide
Doxorubicin {u} (Compound) downregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Doxorubicin {u} (Compound) upregulates {v} (Gene) SREBF2
SREBF2 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Doxorubicin {u} (Compound) binds {v} (Gene) DHCR7
DHCR7 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Doxorubicin {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is downregulated by {v} (Compound) Pimozide
Doxorubicin {u} (Compound) causes {v} (Side Effect) Hypertension
Hypertension {u} (Side Effect) is caused by {v} (Compound) Pimozide
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may lead to a major life threatening interaction when taken with {v} Pimozide
Doxorubicin {u} (Compound) resembles {v} (Compound) Epirubicin
Epirubicin {u} may lead to a major life threatening interaction when taken with {v} Pimozide
Doxorubicin {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Fexofenadine
Fexofenadine {u} (Compound) resembles {v} (Compound) Pimozide
Doxorubicin {u} (Compound) downregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is regulated by {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Pimozide
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pimozide (Compound)
Doxorubicin (Compound) downregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Pimozide (Compound)
Doxorubicin (Compound) upregulates SREBF2 (Gene) and SREBF2 (Gene) is upregulated by Pimozide (Compound)
Doxorubicin (Compound) binds DHCR7 (Gene) and DHCR7 (Gene) is upregulated by Pimozide (Compound)
Doxorubicin (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Pimozide (Compound)
Doxorubicin (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pimozide (Compound)
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may lead to a major life threatening interaction when taken with Pimozide
Doxorubicin (Compound) resembles Epirubicin (Compound) and Epirubicin may lead to a major life threatening interaction when taken with Pimozide
Doxorubicin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Fexofenadine (Compound) and Fexofenadine (Compound) resembles Pimozide (Compound)
Doxorubicin (Compound) downregulates HMOX1 (Gene) and HMOX1 (Gene) is regulated by CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Pimozide (Compound)