DDInter543 DDInter1180
Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. Dicyclomine was granted FDA approval on 11 May 1950.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Dicyclomine {u} (Compound) binds {v} (Gene) CHRM3
Dicyclomine {u} (Compound) causes {v} (Side Effect) Transient global amnesia
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Trichlormethiazide
Dicyclomine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digoxin
Dicyclomine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Arbutamine
Dicyclomine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tacrine
Dicyclomine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Dicyclomine {u} may lead to a major life threatening interaction when taken with {v} Zonisamide
Dicyclomine (Compound) binds CHRM3 (Gene)
Dicyclomine (Compound) causes Transient global amnesia (Side Effect)
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Digoxin
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Arbutamine
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Tacrine
Dicyclomine may lead to a major life threatening interaction when taken with Potassium chloride
Dicyclomine may lead to a major life threatening interaction when taken with Zonisamide