DDInter1956 DDInter1033
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Zalcitabine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Leflunomide
Zalcitabine {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Leflunomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Leflunomide
Zalcitabine {u} (Compound) resembles {v} (Compound) Emtricitabine
Emtricitabine {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Zalcitabine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Losartan
Losartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Zalcitabine {u} (Compound) downregulates {v} (Gene) GDF15
GDF15 {u} (Gene) is associated with {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Leflunomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Neutropenia
Neutropenia {u} (Side Effect) is caused by {v} (Compound) Telbivudine
Telbivudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Rash maculo-papular
Rash maculo-papular {u} (Side Effect) is caused by {v} (Compound) Ganciclovir
Ganciclovir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Leflunomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Nail disorder
Nail disorder {u} (Side Effect) is caused by {v} (Compound) Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Zalcitabine {u} (Compound) causes {v} (Side Effect) Bursitis
Bursitis {u} (Side Effect) is caused by {v} (Compound) Bupropion
Bupropion {u} may lead to a major life threatening interaction when taken with {v} Leflunomide
Zalcitabine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Zalcitabine (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Leflunomide (Compound)
Zalcitabine (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Zalcitabine (Compound) resembles Emtricitabine (Compound) and Emtricitabine may lead to a major life threatening interaction when taken with Leflunomide
Zalcitabine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Losartan (Compound) and Losartan may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Zalcitabine (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is associated with systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Leflunomide (Compound)
Zalcitabine (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Telbivudine (Compound) and Telbivudine may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Zalcitabine (Compound) causes Rash maculo-papular (Side Effect) and Rash maculo-papular (Side Effect) is caused by Ganciclovir (Compound) and Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Leflunomide
Zalcitabine (Compound) causes Nail disorder (Side Effect) and Nail disorder (Side Effect) is caused by Isotretinoin (Compound) and Isotretinoin may lead to a major life threatening interaction when taken with Leflunomide
Zalcitabine (Compound) causes Bursitis (Side Effect) and Bursitis (Side Effect) is caused by Bupropion (Compound) and Bupropion may lead to a major life threatening interaction when taken with Leflunomide