DDInter624 DDInter763
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Efavirenz {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Suprofen
Suprofen {u} (Compound) resembles {v} (Compound) Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Clorazepic acid
Clorazepic acid {u} (Compound) resembles {v} (Compound) Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) resembles {v} (Compound) Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Parosmia
Parosmia {u} (Side Effect) is caused by {v} (Compound) Fluvoxamine
Fluvoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Sinusitis
Sinusitis {u} (Side Effect) is caused by {v} (Compound) Oxaprozin
Oxaprozin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Glaucoma
Glaucoma {u} (Side Effect) is caused by {v} (Compound) Donepezil
Donepezil {u} may cause a minor interaction that can limit clinical effects when taken with {v} Flurbiprofen
Efavirenz {u} (Compound) treats {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) downregulates {v} (Gene) AGL
AGL {u} (Gene) is upregulated by {v} (Compound) Flurbiprofen
Efavirenz {u} (Compound) causes {v} (Side Effect) Nephrolithiasis
Nephrolithiasis {u} (Side Effect) is caused by {v} (Compound) Nizatidine
Nizatidine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Flurbiprofen
Efavirenz (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Flurbiprofen (Compound)
Efavirenz (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Efavirenz (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Suprofen (Compound) and Suprofen (Compound) resembles Flurbiprofen (Compound)
Efavirenz (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Clorazepic acid (Compound) and Clorazepic acid (Compound) resembles Flurbiprofen (Compound)
Efavirenz (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) resembles Flurbiprofen (Compound)
Efavirenz (Compound) causes Parosmia (Side Effect) and Parosmia (Side Effect) is caused by Fluvoxamine (Compound) and Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Efavirenz (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Oxaprozin (Compound) and Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Efavirenz (Compound) causes Glaucoma (Side Effect) and Glaucoma (Side Effect) is caused by Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Flurbiprofen
Efavirenz (Compound) treats acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) downregulates AGL (Gene) and AGL (Gene) is upregulated by Flurbiprofen (Compound)
Efavirenz (Compound) causes Nephrolithiasis (Side Effect) and Nephrolithiasis (Side Effect) is caused by Nizatidine (Compound) and Nizatidine may cause a minor interaction that can limit clinical effects when taken with Flurbiprofen