DDInter1961 DDInter134
A dideoxynucleoside compound in which the 3&#39;-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Zidovudine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atovaquone
Zidovudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Simvastatin
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Azelastine
Azelastine {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Apalutamide
Apalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Simvastatin
Simvastatin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atovaquone
Zidovudine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine {u} may lead to a major life threatening interaction when taken with {v} Peginterferon alfa-2b
Peginterferon alfa-2b {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Cimetidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Cimetidine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Atovaquone
Zidovudine {u} may lead to a major life threatening interaction when taken with {v} Teriflunomide
Teriflunomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Anisindione {u} (Compound) resembles {v} (Compound) Atovaquone
Zidovudine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atovaquone (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a minor interaction that can limit clinical effects when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Zidovudine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Azelastine (Compound) and Azelastine (Compound) resembles Atovaquone (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atovaquone (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Zidovudine may lead to a major life threatening interaction when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Zidovudine may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)
Zidovudine may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Atovaquone (Compound)
Zidovudine may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione (Compound) resembles Atovaquone (Compound)