DDInter350 DDInter1232
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discovered that work via this alkylating mechanism, making mitomycin relatively unique in the space of microbiota-derived therapies. Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper Tract Urothelial Cancer (LG-UTUC) - as well as adjunctly to _ab externo_ glaucoma surgeries.
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is upregulated by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) downregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mitomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) STAP2
STAP2 {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is regulated by {v} (Gene) GATA2
GATA2 {u} (Gene) is upregulated by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) FDXR
FDXR {u} (Gene) regulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is upregulated by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) GADD45A
GADD45A {u} (Gene) is associated with {v} (Disease) stomach cancer
stomach cancer {u} (Disease) is treated by {v} (Compound) Mitomycin
Chlorambucil {u} (Compound) upregulates {v} (Gene) PIDD1
PIDD1 {u} (Gene) is regulated by {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Mitomycin
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Mitomycin (Compound)
Chlorambucil (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Mitomycin (Compound)
Chlorambucil (Compound) downregulates MYC (Gene) and MYC (Gene) is downregulated by Mitomycin (Compound)
Chlorambucil (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Mitomycin (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin
Chlorambucil (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Mitomycin (Compound)
Chlorambucil (Compound) upregulates BLCAP (Gene) and BLCAP (Gene) is regulated by GATA2 (Gene) and GATA2 (Gene) is upregulated by Mitomycin (Compound)
Chlorambucil (Compound) upregulates FDXR (Gene) and FDXR (Gene) regulates BLCAP (Gene) and BLCAP (Gene) is upregulated by Mitomycin (Compound)
Chlorambucil (Compound) upregulates GADD45A (Gene) and GADD45A (Gene) is associated with stomach cancer (Disease) and stomach cancer (Disease) is treated by Mitomycin (Compound)
Chlorambucil (Compound) upregulates PIDD1 (Gene) and PIDD1 (Gene) is regulated by UGDH (Gene) and UGDH (Gene) is downregulated by Mitomycin (Compound)