DDInter1971 DDInter154
Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.[L42530,L42535] Zonisamide represents an alternative for patients that remain refractory to established antiepileptic drugs. In 1989, it was approved for commercial use in Japan. The US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383]
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Zonisamide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Azelastine
Zonisamide {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Zonisamide {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Zonisamide {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Clozapine
Clozapine {u} (Compound) resembles {v} (Compound) Azelastine
Zonisamide {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is regulated by {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) is bound by {v} (Compound) Azelastine
Zonisamide {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Zonisamide {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is regulated by {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Zonisamide {u} may lead to a major life threatening interaction when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Buclizine
Buclizine {u} (Compound) resembles {v} (Compound) Azelastine
Zonisamide may lead to a major life threatening interaction when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Zonisamide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Azelastine (Compound)
Zonisamide (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Azelastine (Compound)
Zonisamide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Zonisamide may lead to a major life threatening interaction when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Loxapine and Loxapine (Compound) resembles Azelastine (Compound)
Zonisamide (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clozapine (Compound) and Clozapine (Compound) resembles Azelastine (Compound)
Zonisamide (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is regulated by CYP1A1 (Gene) and CYP1A1 (Gene) is bound by Azelastine (Compound)
Zonisamide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Zonisamide (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is regulated by PROS1 (Gene) and PROS1 (Gene) is upregulated by Azelastine (Compound)
Zonisamide may lead to a major life threatening interaction when taken with Clemastine and Clemastine (Compound) resembles Buclizine (Compound) and Buclizine (Compound) resembles Azelastine (Compound)