DDInter1232 DDInter150
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discovered that work via this alkylating mechanism, making mitomycin relatively unique in the space of microbiota-derived therapies. Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper Tract Urothelial Cancer (LG-UTUC) - as well as adjunctly to _ab externo_ glaucoma surgeries.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Mitomycin {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) upregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) downregulates {v} (Gene) MRPL12
MRPL12 {u} (Gene) is regulated by {v} (Gene) RRP1B
RRP1B {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Disease) rheumatoid arthritis
rheumatoid arthritis {u} (Disease) is treated by {v} (Compound) Azathioprine
Mitomycin {u} (Compound) downregulates {v} (Gene) INTS3
INTS3 {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Mitomycin (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Azathioprine (Compound)
Mitomycin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)
Mitomycin (Compound) upregulates CYCS (Gene) and CYCS (Gene) is downregulated by Azathioprine (Compound)
Mitomycin (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Azathioprine (Compound)
Mitomycin (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Mitomycin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Mitomycin (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Mitomycin (Compound) downregulates MRPL12 (Gene) and MRPL12 (Gene) is regulated by RRP1B (Gene) and RRP1B (Gene) is downregulated by Azathioprine (Compound)
Mitomycin (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by rheumatoid arthritis (Disease) and rheumatoid arthritis (Disease) is treated by Azathioprine (Compound)
Mitomycin (Compound) downregulates INTS3 (Gene) and INTS3 (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Azathioprine (Compound)