DDInter1404 DDInter721
Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia cells have low levels of this enzyme and depend on exogenous sources. Therefore, the use of pegaspargase results in leukemic cell death.[A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic leukemia (ALL). However, using L-asparaginase derived from _Escherich
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Atomoxetine
Atomoxetine {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Bromodiphenhydramine {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Warfarin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} may lead to a major life threatening interaction when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Flurbiprofen
Flurbiprofen {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Labetalol
Labetalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) resembles {v} (Compound) Fenoprofen
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Bromodiphenhydramine (Compound) and Bromodiphenhydramine (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Labetalol and Labetalol (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Flurbiprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin (Compound) resembles Flurbiprofen (Compound) and Warfarin may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen (Compound) resembles Fenoprofen (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) resembles Fenoprofen (Compound)