DDInter1334 DDInter957
Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase, subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene. Olsalazine is used in the treatment of ulcerative colitis.[L45023,L45151]
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Piroxicam
Piroxicam {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Repaglinide
Repaglinide {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Olsalazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Warfarin {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Olsalazine {u} (Compound) resembles {v} (Compound) Magnesium salicylate
Magnesium salicylate {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Olsalazine {u} (Compound) resembles {v} (Compound) Magnesium salicylate
Magnesium salicylate {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Olsalazine {u} (Compound) treats {v} (Disease) ulcerative colitis
ulcerative colitis {u} (Disease) is associated with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Olsalazine {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Iohexol {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iodipamide
Olsalazine {u} may lead to a major life threatening interaction when taken with {v} Iodixanol
Iodixanol {u} (Compound) is included by {v} (Pharmacologic Class) X-Ray Contrast Activity
X-Ray Contrast Activity {u} (Pharmacologic Class) includes {v} (Compound) Iodipamide
Olsalazine {u} may lead to a major life threatening interaction when taken with {v} Iohexol
Iohexol {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Iodipamide
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Valaciclovir
Valaciclovir {u} (Compound) downregulates {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Iodipamide
Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)
Olsalazine may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Olsalazine (Compound) resembles Magnesium salicylate (Compound) and Magnesium salicylate (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Olsalazine (Compound) resembles Magnesium salicylate (Compound) and Magnesium salicylate (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)
Olsalazine (Compound) treats ulcerative colitis (Disease) and ulcerative colitis (Disease) is associated with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Olsalazine may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iodipamide (Compound)
Olsalazine may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) is included by X-Ray Contrast Activity (Pharmacologic Class) and X-Ray Contrast Activity (Pharmacologic Class) includes Iodipamide (Compound)
Olsalazine may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Iodipamide (Compound)
Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Valaciclovir and Valaciclovir (Compound) downregulates NVL (Gene) and NVL (Gene) is downregulated by Iodipamide (Compound)