DDInter56 DDInter808
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin.[A252330,L43125] Alteplase is a purified glycoprotein of 527 amino acids expressed in Chinese hamster ovary (CHO) cells.[A252345,L43125] It was first approved by the FDA in 1987 for the management of thromboembolic disease, including acute myocardial infarction (AMI). The use of alteplase to manage AMI has decreased thanks to the availability of safer treatments such as angioplasty and stenting. However, its use for the treatment of acute ischem
Garlic allergenic extract is used in allergenic testing.
Alteplase {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Alteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ticlopidine
Alteplase {u} may lead to a major life threatening interaction when taken with {v} Desirudin
Alteplase {u} may lead to a major life threatening interaction when taken with {v} Lepirudin
Alteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine
Alteplase may lead to a major life threatening interaction when taken with Desirudin
Alteplase may lead to a major life threatening interaction when taken with Lepirudin