DDInter852 DDInter119
Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Halofantrine {u} (Compound) resembles {v} (Compound) Lumefantrine
Halofantrine {u} (Compound) binds {v} (Gene) CYP2C8
Halofantrine {u} (Compound) upregulates {v} (Gene) HMOX1
Halofantrine {u} (Compound) downregulates {v} (Gene) CDC20
Halofantrine {u} (Compound) causes {v} (Side Effect) Gastrointestinal pain
Halofantrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tolterodine
Halofantrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Halofantrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Thalidomide
Halofantrine {u} may lead to a major life threatening interaction when taken with {v} Dasatinib
Halofantrine {u} may lead to a major life threatening interaction when taken with {v} Amiodarone
Halofantrine (Compound) resembles Lumefantrine (Compound)
Halofantrine (Compound) binds CYP2C8 (Gene)
Halofantrine (Compound) upregulates HMOX1 (Gene)
Halofantrine (Compound) downregulates CDC20 (Gene)
Halofantrine (Compound) causes Gastrointestinal pain (Side Effect)
Halofantrine may cause a minor interaction that can limit clinical effects when taken with Tolterodine
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Halofantrine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Halofantrine may lead to a major life threatening interaction when taken with Dasatinib
Halofantrine may lead to a major life threatening interaction when taken with Amiodarone