DDInter921 DDInter704
Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid. The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is the main enzyme responsible for catalyzes the rate-limiting step in prostaglandin and thromboxane biosynthesis via the arachidonic acid (AA) pathway. Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Indomethacin {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Indomethacin {u} (Compound) upregulates {v} (Gene) GNAI1
GNAI1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Indomethacin {u} (Compound) binds {v} (Gene) PPARG
PPARG {u} (Gene) is downregulated by {v} (Compound) Everolimus
Indomethacin {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Everolimus
Indomethacin {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Indomethacin {u} (Compound) upregulates {v} (Gene) GNAI1
GNAI1 {u} (Gene) is regulated by {v} (Gene) MTOR
MTOR {u} (Gene) is bound by {v} (Compound) Everolimus
Indomethacin {u} (Compound) binds {v} (Gene) PPARG
PPARG {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Indomethacin {u} (Compound) causes {v} (Side Effect) Pneumothorax
Pneumothorax {u} (Side Effect) is caused by {v} (Compound) Tacrolimus
Tacrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Indomethacin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Indomethacin {u} (Compound) resembles {v} (Compound) Agomelatine
Agomelatine {u} (Compound) causes {v} (Side Effect) Influenza
Influenza {u} (Side Effect) is caused by {v} (Compound) Everolimus
Indomethacin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Indomethacin (Compound) upregulates GNAI1 (Gene) and GNAI1 (Gene) is upregulated by Everolimus (Compound)
Indomethacin (Compound) binds PPARG (Gene) and PPARG (Gene) is downregulated by Everolimus (Compound)
Indomethacin (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Everolimus (Compound)
Indomethacin may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Indomethacin (Compound) upregulates GNAI1 (Gene) and GNAI1 (Gene) is regulated by MTOR (Gene) and MTOR (Gene) is bound by Everolimus (Compound)
Indomethacin (Compound) binds PPARG (Gene) and PPARG (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Everolimus (Compound)
Indomethacin (Compound) causes Pneumothorax (Side Effect) and Pneumothorax (Side Effect) is caused by Tacrolimus (Compound) and Tacrolimus (Compound) resembles Everolimus (Compound)
Indomethacin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Indomethacin (Compound) resembles Agomelatine (Compound) and Agomelatine (Compound) causes Influenza (Side Effect) and Influenza (Side Effect) is caused by Everolimus (Compound)