DDInter1024 DDInter556
Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1) tyrosine kinases inhibitor. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.
Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis. It was marketed in 1911.
Lapatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxycodone
Oxycodone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Dihydrocodeine
Lapatinib {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Dihydrocodeine
Lapatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Hydrocodone
Hydrocodone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxycodone
Oxycodone {u} (Compound) resembles {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Mediastinal disorder {u} (Side Effect) is caused by {v} (Compound) Oxymorphone
Oxymorphone {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib {u} (Compound) upregulates {v} (Gene) HERC6
HERC6 {u} (Gene) is upregulated by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Dihydrocodeine
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Galantamine and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Dihydrocodeine (Compound)
Lapatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dihydrocodeine (Compound)
Lapatinib (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Dihydrocodeine (Compound)
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Galantamine and Galantamine (Compound) resembles Hydrocodone (Compound) and Hydrocodone (Compound) resembles Dihydrocodeine (Compound)
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Lapatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Lapatinib (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)
Lapatinib (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Oxymorphone (Compound) and Oxymorphone (Compound) resembles Dihydrocodeine (Compound)
Lapatinib (Compound) upregulates HERC6 (Gene) and HERC6 (Gene) is upregulated by Galantamine (Compound) and Galantamine (Compound) resembles Dihydrocodeine (Compound)