DDInter1158 DDInter1968
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid was first described in the literature in 1994. Zoledronic acid was granted FDA approval on 20 August 2001.
Mesalazine {u} (Compound) causes {v} (Side Effect) Nephropathy toxic
Nephropathy toxic {u} (Side Effect) is caused by {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zoledronic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Nephropathy toxic
Nephropathy toxic {u} (Side Effect) is caused by {v} (Compound) Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Thalidomide
Thalidomide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zoledronic acid
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Clodronate
Clodronate {u} (Compound) resembles {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pamidronic acid
Pamidronic acid {u} (Compound) resembles {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Risedronic acid
Risedronic acid {u} (Compound) resembles {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibandronate
Ibandronate {u} (Compound) resembles {v} (Compound) Zoledronic acid
Mesalazine {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Acetylsalicylic acid
Acetylsalicylic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zoledronic acid
Mesalazine (Compound) causes Nephropathy toxic (Side Effect) and Nephropathy toxic (Side Effect) is caused by Zoledronic acid (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid
Mesalazine (Compound) causes Nephropathy toxic (Side Effect) and Nephropathy toxic (Side Effect) is caused by Pamidronic acid (Compound) and Pamidronic acid (Compound) resembles Zoledronic acid (Compound)
Mesalazine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Ibandronate (Compound) and Ibandronate (Compound) resembles Zoledronic acid (Compound)
Mesalazine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Clodronate (Compound) and Clodronate (Compound) resembles Zoledronic acid (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Pamidronic acid and Pamidronic acid (Compound) resembles Zoledronic acid (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Risedronic acid (Compound) and Risedronic acid (Compound) resembles Zoledronic acid (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate (Compound) resembles Zoledronic acid (Compound)
Mesalazine (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Acetylsalicylic acid (Compound) and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Zoledronic acid