DDInter596 DDInter809
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and the generation of reactive oxygen species. Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin’s and Hodgkin’s lymphoma, multiple myel
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan. The FDA withdrew its approval for the use of non-ophthalmic drug products containing gatifloxacin due to the high prevalence of gatifloxacin-associated dysglycemia adverse event reports and the high incidence of hyperglycemic and hypoglycemic episodes in patients taking gatifloxacin compared to those on macrolide antibiotics.[L43942,L44037]
Doxorubicin {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) downregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) upregulates {v} (Gene) CTSL
CTSL {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) causes {v} (Side Effect) Gastritis
Gastritis {u} (Side Effect) is caused by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) resembles {v} (Compound) Daunorubicin
Daunorubicin {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Doxorubicin {u} (Compound) resembles {v} (Compound) Idarubicin
Idarubicin {u} may lead to a major life threatening interaction when taken with {v} Gatifloxacin
Doxorubicin {u} (Compound) upregulates {v} (Gene) SSBP2
SSBP2 {u} (Gene) regulates {v} (Gene) PGAM1
PGAM1 {u} (Gene) is downregulated by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) upregulates {v} (Gene) DYRK3
DYRK3 {u} (Gene) is regulated by {v} (Gene) PAK1
PAK1 {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Doxorubicin {u} (Compound) downregulates {v} (Gene) CCNB1
CCNB1 {u} (Gene) is regulated by {v} (Gene) BID
BID {u} (Gene) is upregulated by {v} (Compound) Gatifloxacin
Doxorubicin (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) is upregulated by Gatifloxacin (Compound)
Doxorubicin (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is upregulated by Gatifloxacin (Compound)
Doxorubicin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Gatifloxacin (Compound)
Doxorubicin (Compound) upregulates CTSL (Gene) and CTSL (Gene) is downregulated by Gatifloxacin (Compound)
Doxorubicin (Compound) causes Gastritis (Side Effect) and Gastritis (Side Effect) is caused by Gatifloxacin (Compound)
Doxorubicin (Compound) resembles Daunorubicin (Compound) and Daunorubicin may lead to a major life threatening interaction when taken with Gatifloxacin
Doxorubicin (Compound) resembles Idarubicin (Compound) and Idarubicin may lead to a major life threatening interaction when taken with Gatifloxacin
Doxorubicin (Compound) upregulates SSBP2 (Gene) and SSBP2 (Gene) regulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Gatifloxacin (Compound)
Doxorubicin (Compound) upregulates DYRK3 (Gene) and DYRK3 (Gene) is regulated by PAK1 (Gene) and PAK1 (Gene) is upregulated by Gatifloxacin (Compound)
Doxorubicin (Compound) downregulates CCNB1 (Gene) and CCNB1 (Gene) is regulated by BID (Gene) and BID (Gene) is upregulated by Gatifloxacin (Compound)