DDInter118 DDInter1676
Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism of alpha-adrenergic and 5-HT2A receptors.[L45859,A4393] Aripiprazole was given FDA approval on November 15, 2002.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Aripiprazole {u} (Compound) resembles {v} (Compound) Nefazodone
Aripiprazole {u} (Compound) resembles {v} (Compound) Trazodone
Aripiprazole {u} (Compound) binds {v} (Gene) ADRA1B
Aripiprazole {u} (Compound) upregulates {v} (Gene) AARS
Aripiprazole {u} (Compound) palliates {v} (Disease) bipolar disorder
Aripiprazole {u} (Compound) downregulates {v} (Gene) PCNA
Aripiprazole {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Aripiprazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Aripiprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Abarelix
Aripiprazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triclabendazole
Aripiprazole (Compound) resembles Nefazodone (Compound)
Aripiprazole (Compound) resembles Trazodone (Compound)
Aripiprazole (Compound) binds ADRA1B (Gene)
Aripiprazole (Compound) upregulates AARS (Gene)
Aripiprazole (Compound) palliates bipolar disorder (Disease)
Aripiprazole (Compound) downregulates PCNA (Gene)
Aripiprazole (Compound) causes Orthostatic hypotension (Side Effect)
Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Abarelix
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole