DDInter355 DDInter576
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is treated by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) is associated with {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) upregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) upregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) downregulates {v} (Gene) INSIG1
INSIG1 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) resembles {v} (Compound) Amoxapine
Amoxapine {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Chlordiazepoxide {u} (Compound) palliates {v} (Disease) alcohol dependence
alcohol dependence {u} (Disease) upregulates {v} (Gene) CEBPD
CEBPD {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) is treated by Disulfiram (Compound)
Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) is associated with CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Disulfiram (Compound)
Chlordiazepoxide (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Disulfiram (Compound)
Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Chlordiazepoxide (Compound) resembles Prazepam (Compound) and Prazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Chlordiazepoxide (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) upregulates ACAT2 (Gene) and ACAT2 (Gene) is downregulated by Disulfiram (Compound)
Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) downregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Disulfiram (Compound)
Chlordiazepoxide (Compound) resembles Amoxapine (Compound) and Amoxapine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Chlordiazepoxide (Compound) palliates alcohol dependence (Disease) and alcohol dependence (Disease) upregulates CEBPD (Gene) and CEBPD (Gene) is upregulated by Disulfiram (Compound)