DDInter973 DDInter248
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
Bumetanide is a sulfamyl diuretic.
Irinotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Irinotecan {u} (Compound) upregulates {v} (Gene) SLC12A4
SLC12A4 {u} (Gene) is bound by {v} (Compound) Bumetanide
Irinotecan {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is downregulated by {v} (Compound) Bumetanide
Irinotecan {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Bumetanide
Irinotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Furosemide
Furosemide {u} (Compound) resembles {v} (Compound) Bumetanide
Irinotecan {u} (Compound) upregulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Fenoprofen
Fenoprofen {u} (Compound) resembles {v} (Compound) Bumetanide
Irinotecan {u} (Compound) downregulates {v} (Gene) COTL1
COTL1 {u} (Gene) is regulated by {v} (Gene) CA12
CA12 {u} (Gene) is bound by {v} (Compound) Bumetanide
Irinotecan {u} (Compound) causes {v} (Side Effect) Pancreatitis
Pancreatitis {u} (Side Effect) is caused by {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Irinotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metolazone
Metolazone {u} (Compound) resembles {v} (Compound) Indapamide
Indapamide {u} (Compound) resembles {v} (Compound) Bumetanide
Irinotecan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indapamide
Indapamide {u} (Compound) treats {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Bumetanide
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Bumetanide (Compound)
Irinotecan (Compound) upregulates SLC12A4 (Gene) and SLC12A4 (Gene) is bound by Bumetanide (Compound)
Irinotecan (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Bumetanide (Compound)
Irinotecan (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Bumetanide (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Furosemide (Compound) and Furosemide (Compound) resembles Bumetanide (Compound)
Irinotecan (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Fenoprofen (Compound) and Fenoprofen (Compound) resembles Bumetanide (Compound)
Irinotecan (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is regulated by CA12 (Gene) and CA12 (Gene) is bound by Bumetanide (Compound)
Irinotecan (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Indapamide (Compound) and Indapamide (Compound) resembles Bumetanide (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound) and Indapamide (Compound) resembles Bumetanide (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) treats hypertension (Disease) and hypertension (Disease) is treated by Bumetanide (Compound)