DDInter675 DDInter763
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Esmolol {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Flurbiprofen
Esmolol {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Flurbiprofen
Esmolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Esmolol {u} (Compound) resembles {v} (Compound) Pindolol
Pindolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Esmolol {u} (Compound) resembles {v} (Compound) Acebutolol
Acebutolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Esmolol {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Flurbiprofen
Esmolol {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) UGT1A9
UGT1A9 {u} (Gene) is bound by {v} (Compound) Flurbiprofen
Esmolol {u} (Compound) downregulates {v} (Gene) ACAT2
ACAT2 {u} (Gene) regulates {v} (Gene) AGL
AGL {u} (Gene) is upregulated by {v} (Compound) Flurbiprofen
Esmolol {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Clorazepic acid
Clorazepic acid {u} (Compound) resembles {v} (Compound) Flurbiprofen
Esmolol {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Tiaprofenic acid
Tiaprofenic acid {u} (Compound) resembles {v} (Compound) Flurbiprofen
Esmolol (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Flurbiprofen (Compound)
Esmolol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Esmolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Esmolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Esmolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Esmolol (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Flurbiprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Esmolol (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by UGT1A9 (Gene) and UGT1A9 (Gene) is bound by Flurbiprofen (Compound)
Esmolol (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene) regulates AGL (Gene) and AGL (Gene) is upregulated by Flurbiprofen (Compound)
Esmolol (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Clorazepic acid (Compound) and Clorazepic acid (Compound) resembles Flurbiprofen (Compound)
Esmolol (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Tiaprofenic acid (Compound) and Tiaprofenic acid (Compound) resembles Flurbiprofen (Compound)