DDInter1233 DDInter1555
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
The 3-cyclopentyl ether of ethinyl estradiol.
Mitotane {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Estramustine
Estramustine {u} (Compound) resembles {v} (Compound) Quinestrol
Mitotane {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Quinestrol
Mitotane {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Quinestrol
Mitotane {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Anastrozole
Anastrozole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Mitotane {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Nilotinib
Nilotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Quinestrol
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is downregulated by {v} (Compound) Levonorgestrel
Levonorgestrel {u} (Compound) resembles {v} (Compound) Quinestrol
Mitotane {u} (Compound) upregulates {v} (Gene) EIF4EBP1
EIF4EBP1 {u} (Gene) is upregulated by {v} (Compound) Vemurafenib
Vemurafenib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Quinestrol
Mitotane {u} (Compound) upregulates {v} (Gene) ADGRE5
ADGRE5 {u} (Gene) is downregulated by {v} (Compound) Danazol
Danazol {u} (Compound) resembles {v} (Compound) Quinestrol
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Danazol
Danazol {u} (Compound) resembles {v} (Compound) Quinestrol
Mitotane (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Estramustine (Compound) and Estramustine (Compound) resembles Quinestrol (Compound)
Mitotane (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Mitotane (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a minor interaction that can limit clinical effects when taken with Quinestrol
Mitotane (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Anastrozole (Compound) and Anastrozole may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol
Mitotane (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Nilotinib (Compound) and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Mitotane (Compound) upregulates ADGRE5 (Gene) and ADGRE5 (Gene) is downregulated by Levonorgestrel (Compound) and Levonorgestrel (Compound) resembles Quinestrol (Compound)
Mitotane (Compound) upregulates EIF4EBP1 (Gene) and EIF4EBP1 (Gene) is upregulated by Vemurafenib (Compound) and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol
Mitotane (Compound) upregulates ADGRE5 (Gene) and ADGRE5 (Gene) is downregulated by Danazol (Compound) and Danazol (Compound) resembles Quinestrol (Compound)
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Danazol (Compound) and Danazol (Compound) resembles Quinestrol (Compound)