DDInter1938 DDInter1291
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer durations of action. The most popular of the third generation dihydropyridines is [amlodipine]. Nifedipine was granted FDA approval on 31 December 1981.
Vincristine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nifedipine
Vincristine {u} (Compound) downregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Vincristine {u} (Compound) downregulates {v} (Gene) UBE2A
UBE2A {u} (Gene) is downregulated by {v} (Compound) Nifedipine
Vincristine {u} (Compound) upregulates {v} (Gene) JMJD6
JMJD6 {u} (Gene) is downregulated by {v} (Compound) Nifedipine
Vincristine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Nifedipine
Vincristine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nifedipine
Vincristine {u} (Compound) binds {v} (Gene) CYP3A7-CYP3A51P
CYP3A7-CYP3A51P {u} (Gene) is bound by {v} (Compound) Lercanidipine
Lercanidipine {u} (Compound) resembles {v} (Compound) Nifedipine
Vincristine {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Vincristine {u} (Compound) downregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is regulated by {v} (Gene) MYC
MYC {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Vincristine {u} (Compound) downregulates {v} (Gene) UBE2A
UBE2A {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nifedipine
Vincristine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nifedipine (Compound)
Vincristine (Compound) downregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Nifedipine (Compound)
Vincristine (Compound) downregulates UBE2A (Gene) and UBE2A (Gene) is downregulated by Nifedipine (Compound)
Vincristine (Compound) upregulates JMJD6 (Gene) and JMJD6 (Gene) is downregulated by Nifedipine (Compound)
Vincristine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Nifedipine (Compound)
Vincristine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nicardipine (Compound) and Nicardipine (Compound) resembles Nifedipine (Compound)
Vincristine (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Lercanidipine (Compound) and Lercanidipine (Compound) resembles Nifedipine (Compound)
Vincristine (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Nifedipine (Compound)
Vincristine (Compound) downregulates PHGDH (Gene) and PHGDH (Gene) is regulated by MYC (Gene) and MYC (Gene) is upregulated by Nifedipine (Compound)
Vincristine (Compound) downregulates UBE2A (Gene) and UBE2A (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Nifedipine (Compound)