DDInter178 DDInter1623
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotarix is a live attenuated vaccine containing the 89-12 human strain.[Label] Rotavirus vaccines are 90% effective in protecting against severe rotavirus infection.
Rotavirus vaccine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Budesonide
Rotavirus vaccine {u} may lead to a major life threatening interaction when taken with {v} Carmustine
Rotavirus vaccine {u} may lead to a major life threatening interaction when taken with {v} Sarilumab
Rotavirus vaccine may cause a moderate interaction that could exacerbate diseases when taken with Budesonide
Rotavirus vaccine may lead to a major life threatening interaction when taken with Carmustine
Rotavirus vaccine may lead to a major life threatening interaction when taken with Sarilumab