DDInter11 DDInter624
Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are responsible for the metabolism of complex starches and oligo-, tri-, and disaccharides into absorbable simple sugars.[L31633,A37868] By inhibiting the activity of these enzymes, acarbose limits the absorption of dietary carbohydrates and the subsequent postprandial increase in blood glucose and insulin levels. Acarbose is therefore used in conjunction with diet, exercise, and other pharmacotherapies for the management of blood sugar levels in patients with type 2 diabetes.[L31628,L31633] Acarbose is one of only two approved alpha-glucosidase inhibitors (the other being
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Acarbose {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Acarbose {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) causes {v} (Side Effect) Apnoea
Apnoea {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Neomycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Acarbose {u} (Compound) treats {v} (Disease) type 2 diabetes mellitus
type 2 diabetes mellitus {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Efavirenz
Acarbose {u} (Compound) binds {v} (Gene) GAA
GAA {u} (Gene) regulates {v} (Gene) TBX2
TBX2 {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Acarbose {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) covaries with {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Efavirenz
Acarbose {u} (Compound) binds {v} (Gene) GAA
GAA {u} (Gene) is regulated by {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Acarbose {u} (Compound) upregulates {v} (Gene) EAPP
EAPP {u} (Gene) regulates {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Acarbose {u} (Compound) upregulates {v} (Gene) PAK1
PAK1 {u} (Gene) regulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Acarbose {u} (Compound) binds {v} (Gene) GAA
GAA {u} (Gene) regulates {v} (Gene) PFN1
PFN1 {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Acarbose (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Efavirenz (Compound)
Acarbose (Compound) resembles Amikacin (Compound) and Amikacin (Compound) causes Apnoea (Side Effect) and Apnoea (Side Effect) is caused by Efavirenz (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Efavirenz (Compound)
Acarbose (Compound) treats type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Efavirenz (Compound)
Acarbose (Compound) binds GAA (Gene) and GAA (Gene) regulates TBX2 (Gene) and TBX2 (Gene) is upregulated by Efavirenz (Compound)
Acarbose (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) covaries with CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Efavirenz (Compound)
Acarbose (Compound) binds GAA (Gene) and GAA (Gene) is regulated by POLR2I (Gene) and POLR2I (Gene) is downregulated by Efavirenz (Compound)
Acarbose (Compound) upregulates EAPP (Gene) and EAPP (Gene) regulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Efavirenz (Compound)
Acarbose (Compound) upregulates PAK1 (Gene) and PAK1 (Gene) regulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Acarbose (Compound) binds GAA (Gene) and GAA (Gene) regulates PFN1 (Gene) and PFN1 (Gene) is downregulated by Efavirenz (Compound)