DDInter98 DDInter1763
Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver.
Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Anisindione {u} (Compound) resembles {v} (Compound) Diltiazem
Diltiazem {u} (Compound) binds {v} (Gene) CYP3A7
CYP3A7 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) resembles {v} (Compound) Oxybenzone
Oxybenzone {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) resembles {v} (Compound) Menadione
Menadione {u} (Compound) upregulates {v} (Gene) TF
TF {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) resembles {v} (Compound) Monobenzone
Monobenzone {u} (Compound) upregulates {v} (Gene) WIF1
WIF1 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) resembles {v} (Compound) Monobenzone
Monobenzone {u} (Compound) downregulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) binds {v} (Gene) GGCX
GGCX {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) resembles {v} (Compound) Menadione
Menadione {u} (Compound) downregulates {v} (Gene) CDK19
CDK19 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Acarbose
Acarbose {u} (Compound) downregulates {v} (Gene) TRIB3
TRIB3 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Anisindione {u} (Compound) binds {v} (Gene) GGCX
GGCX {u} (Gene) regulates {v} (Gene) KIAA0355
KIAA0355 {u} (Gene) is upregulated by {v} (Compound) Temsirolimus
Anisindione {u} may cause a minor interaction that can limit clinical effects when taken with {v} Simvastatin
Simvastatin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Temsirolimus
Anisindione (Compound) resembles Diltiazem (Compound) and Diltiazem (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Temsirolimus (Compound)
Anisindione (Compound) resembles Oxybenzone (Compound) and Oxybenzone (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Temsirolimus (Compound)
Anisindione (Compound) resembles Menadione (Compound) and Menadione (Compound) upregulates TF (Gene) and TF (Gene) is upregulated by Temsirolimus (Compound)
Anisindione (Compound) resembles Monobenzone (Compound) and Monobenzone (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Temsirolimus (Compound)
Anisindione (Compound) resembles Monobenzone (Compound) and Monobenzone (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Temsirolimus (Compound)
Anisindione (Compound) binds GGCX (Gene) and GGCX (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Temsirolimus (Compound)
Anisindione (Compound) resembles Menadione (Compound) and Menadione (Compound) downregulates CDK19 (Gene) and CDK19 (Gene) is upregulated by Temsirolimus (Compound)
Anisindione may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose (Compound) downregulates TRIB3 (Gene) and TRIB3 (Gene) is upregulated by Temsirolimus (Compound)
Anisindione (Compound) binds GGCX (Gene) and GGCX (Gene) regulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Temsirolimus (Compound)
Anisindione may cause a minor interaction that can limit clinical effects when taken with Simvastatin and Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Temsirolimus (Compound)