DDInter1305 DDInter1639
Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Nitroprusside {u} (Compound) binds {v} (Gene) CYP1A1
CYP1A1 {u} (Gene) regulates {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Sapropterin
Nitroprusside {u} (Compound) binds {v} (Gene) GUCY1B3
GUCY1B3 {u} (Gene) interacts with {v} (Gene) NOS3
NOS3 {u} (Gene) is bound by {v} (Compound) Sapropterin
Nitroprusside (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) regulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Sapropterin (Compound)
Nitroprusside (Compound) binds GUCY1B3 (Gene) and GUCY1B3 (Gene) interacts with NOS3 (Gene) and NOS3 (Gene) is bound by Sapropterin (Compound)