DDInter562 DDInter535
Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and dizziness caused by motion sickness.[L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline. The antiemetic properties of dimenhydrinate are primarily thought to be produced by diphenhydramine
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Dimenhydrinate {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) resembles {v} (Compound) Modafinil
Modafinil {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) resembles {v} (Compound) Modafinil
Modafinil {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) resembles {v} (Compound) Diphenylpyraline
Diphenylpyraline {u} (Compound) downregulates {v} (Gene) LPAR2
LPAR2 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Dimenhydrinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diphenhydramine
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Dimenhydrinate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cyclizine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) binds {v} (Gene) HRH1
HRH1 {u} (Gene) regulates {v} (Gene) ADI1
ADI1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Dimenhydrinate {u} (Compound) palliates {v} (Disease) schizophrenia
schizophrenia {u} (Disease) downregulates {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Diazoxide
Dimenhydrinate (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Dimenhydrinate (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Dimenhydrinate (Compound) resembles Modafinil (Compound) and Modafinil (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Diazoxide (Compound)
Dimenhydrinate (Compound) resembles Modafinil (Compound) and Modafinil (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Dimenhydrinate (Compound) resembles Diphenylpyraline (Compound) and Diphenylpyraline (Compound) downregulates LPAR2 (Gene) and LPAR2 (Gene) is upregulated by Diazoxide (Compound)
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Diazoxide (Compound)
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Diazoxide (Compound)
Dimenhydrinate (Compound) binds HRH1 (Gene) and HRH1 (Gene) regulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Diazoxide (Compound)
Dimenhydrinate (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Diazoxide (Compound)
Dimenhydrinate (Compound) palliates schizophrenia (Disease) and schizophrenia (Disease) downregulates CA2 (Gene) and CA2 (Gene) is bound by Diazoxide (Compound)