DDInter549 DDInter1960
Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. It is approved by the FDA to treat acute and chronic diarrhea. Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination with atropine in the brand mixture Lomotil(R). It works mostly in the periphery and activates opioid receptors in the intestine rather than the central nervous system (CNS). [3] Difenoxin is also closely related to loperamide, but unlike loper
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.[A202829, A202832] Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.[A202829, A202835, A202838, A202841, A202850, A202859, L13389] Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt. To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.
Difenoxin {u} (Compound) resembles {v} (Compound) Diphenidol
Difenoxin {u} (Compound) resembles {v} (Compound) Methadone
Difenoxin {u} (Compound) binds {v} (Gene) OPRM1
Difenoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Droperidol
Difenoxin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tetrabenazine
Difenoxin (Compound) resembles Diphenidol (Compound)
Difenoxin (Compound) resembles Methadone (Compound)
Difenoxin (Compound) binds OPRM1 (Gene)
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Droperidol
Difenoxin may cause a moderate interaction that could exacerbate diseases when taken with Tetrabenazine