DDInter78 DDInter1676
Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Amitriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Amitriptyline {u} (Compound) resembles {v} (Compound) Pheniramine
Amitriptyline {u} (Compound) resembles {v} (Compound) Bromodiphenhydramine
Amitriptyline {u} (Compound) treats {v} (Disease) migraine
Amitriptyline {u} (Compound) binds {v} (Gene) KCNQ2
Amitriptyline {u} (Compound) upregulates {v} (Gene) PPP1R13B
Amitriptyline {u} (Compound) palliates {v} (Disease) multiple sclerosis
Amitriptyline {u} (Compound) downregulates {v} (Gene) NUP85
Amitriptyline {u} (Compound) causes {v} (Side Effect) Tinnitus
Amitriptyline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Amitriptyline (Compound) resembles Pheniramine (Compound)
Amitriptyline (Compound) resembles Bromodiphenhydramine (Compound)
Amitriptyline (Compound) treats migraine (Disease)
Amitriptyline (Compound) binds KCNQ2 (Gene)
Amitriptyline (Compound) upregulates PPP1R13B (Gene)
Amitriptyline (Compound) palliates multiple sclerosis (Disease)
Amitriptyline (Compound) downregulates NUP85 (Gene)
Amitriptyline (Compound) causes Tinnitus (Side Effect)
Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole