DDInter1490 DDInter1376
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Polythiazide {u} (Compound) resembles {v} (Compound) Trichlormethiazide
Polythiazide {u} (Compound) resembles {v} (Compound) Methyclothiazide
Polythiazide {u} (Compound) binds {v} (Gene) SLC12A3
Polythiazide {u} (Compound) is included by {v} (Pharmacologic Class) Thiazides
Polythiazide {u} (Compound) causes {v} (Side Effect) Vasculitis necrotising
Polythiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atropine
Polythiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Mepenzolate
Polythiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dulaglutide
Polythiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Polythiazide {u} may lead to a major life threatening interaction when taken with {v} Dolasetron
Polythiazide (Compound) resembles Trichlormethiazide (Compound)
Polythiazide (Compound) resembles Methyclothiazide (Compound)
Polythiazide (Compound) binds SLC12A3 (Gene)
Polythiazide (Compound) is included by Thiazides (Pharmacologic Class)
Polythiazide (Compound) causes Vasculitis necrotising (Side Effect)
Polythiazide may cause a minor interaction that can limit clinical effects when taken with Atropine
Polythiazide may cause a minor interaction that can limit clinical effects when taken with Mepenzolate
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide
Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Polythiazide may lead to a major life threatening interaction when taken with Dolasetron