DDInter1244 DDInter1397
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Morphine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Paroxetine
Morphine {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Anaphylactoid reaction {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Morphine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Morphine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Galantamine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Hydromorphone
Hydromorphone {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Galantamine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Morphine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Morphine {u} (Compound) resembles {v} (Compound) Galantamine
Galantamine {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Morphine {u} may lead to a major life threatening interaction when taken with {v} Nalbuphine
Nalbuphine {u} (Compound) downregulates {v} (Gene) DCK
DCK {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Paroxetine (Compound)
Morphine (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Paroxetine (Compound)
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Morphine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Morphine (Compound) resembles Galantamine (Compound) and Galantamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Morphine may lead to a major life threatening interaction when taken with Hydromorphone and Hydromorphone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Paroxetine (Compound)
Morphine (Compound) resembles Galantamine (Compound) and Galantamine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Paroxetine (Compound)
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Paroxetine (Compound)
Morphine (Compound) resembles Galantamine (Compound) and Galantamine (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Paroxetine (Compound)
Morphine may lead to a major life threatening interaction when taken with Nalbuphine and Nalbuphine (Compound) downregulates DCK (Gene) and DCK (Gene) is downregulated by Paroxetine (Compound)