DDInter458 DDInter1385
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Pancuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Pancuronium
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Pancuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Cyclosporine {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pancuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Irinotecan
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pancuronium
Cyclosporine {u} (Compound) binds {v} (Gene) SLCO1A2
SLCO1A2 {u} (Gene) is bound by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pancuronium
Cyclosporine {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pancuronium
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Pancuronium
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Pancuronium (Compound)
Cyclosporine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Pancuronium (Compound)
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Pancuronium (Compound)
Cyclosporine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Vecuronium (Compound) and Vecuronium (Compound) resembles Pancuronium (Compound)
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Rocuronium (Compound) and Rocuronium (Compound) resembles Pancuronium (Compound)
Cyclosporine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Pancuronium
Cyclosporine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Irinotecan (Compound) and Irinotecan may cause a minor interaction that can limit clinical effects when taken with Pancuronium
Cyclosporine (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium
Cyclosporine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Pancuronium (Compound)