DDInter535 DDInter45
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A phenothiazine derivative that is used as an antipruritic.
Diazoxide {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Alimemazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Alimemazine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Diazoxide {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Triflupromazine
Triflupromazine {u} (Compound) resembles {v} (Compound) Alimemazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Insomnia
Insomnia {u} (Side Effect) is caused by {v} (Compound) Oxcarbazepine
Oxcarbazepine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Methdilazine {u} (Compound) resembles {v} (Compound) Alimemazine
Diazoxide {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Ethopropazine
Ethopropazine {u} (Compound) resembles {v} (Compound) Alimemazine
Diazoxide {u} (Compound) causes {v} (Side Effect) Galactorrhoea
Galactorrhoea {u} (Side Effect) is caused by {v} (Compound) Desipramine
Desipramine {u} (Compound) resembles {v} (Compound) Alimemazine
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) regulates {v} (Gene) ST3GAL5
ST3GAL5 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Diazoxide (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Alimemazine (Compound)
Diazoxide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Alimemazine (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Diazoxide (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Triflupromazine (Compound) and Triflupromazine (Compound) resembles Alimemazine (Compound)
Diazoxide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Oxcarbazepine (Compound) and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Diazoxide (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Ethopropazine (Compound) and Ethopropazine (Compound) resembles Alimemazine (Compound)
Diazoxide (Compound) causes Galactorrhoea (Side Effect) and Galactorrhoea (Side Effect) is caused by Desipramine (Compound) and Desipramine (Compound) resembles Alimemazine (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) regulates ST3GAL5 (Gene) and ST3GAL5 (Gene) is upregulated by Alimemazine (Compound)