DDInter1340 DDInter1298
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
Omeprazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Weight decreased
Weight decreased {u} (Side Effect) is caused by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Nimodipine
Nimodipine {u} (Compound) resembles {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Otitis media
Otitis media {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nisoldipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Vaginal infection
Vaginal infection {u} (Side Effect) is caused by {v} (Compound) Fluconazole
Fluconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nisoldipine
Omeprazole {u} (Compound) resembles {v} (Compound) Pantoprazole
Pantoprazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nisoldipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Melaena
Melaena {u} (Side Effect) is caused by {v} (Compound) Ticagrelor
Ticagrelor {u} may cause a minor interaction that can limit clinical effects when taken with {v} Nisoldipine
Omeprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nisoldipine (Compound)
Omeprazole (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Nisoldipine (Compound)
Omeprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amlodipine (Compound) and Amlodipine (Compound) resembles Nisoldipine (Compound)
Omeprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nimodipine (Compound) and Nimodipine (Compound) resembles Nisoldipine (Compound)
Omeprazole (Compound) causes Weight decreased (Side Effect) and Weight decreased (Side Effect) is caused by Amlodipine (Compound) and Amlodipine (Compound) resembles Nisoldipine (Compound)
Omeprazole (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Nimodipine (Compound) and Nimodipine (Compound) resembles Nisoldipine (Compound)
Omeprazole (Compound) causes Otitis media (Side Effect) and Otitis media (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Nisoldipine
Omeprazole (Compound) causes Vaginal infection (Side Effect) and Vaginal infection (Side Effect) is caused by Fluconazole (Compound) and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Nisoldipine
Omeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nisoldipine (Compound)
Omeprazole (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Ticagrelor (Compound) and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Nisoldipine