DDInter973 DDInter1473
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
Pipecuronium is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent.
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} (Compound) binds {v} (Gene) BCHE
BCHE {u} (Gene) is bound by {v} (Compound) Pipecuronium
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} (Compound) upregulates {v} (Gene) NOTCH1
NOTCH1 {u} (Gene) is upregulated by {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} (Compound) binds {v} (Gene) BCHE
BCHE {u} (Gene) is bound by {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} may cause a minor interaction that can limit clinical effects when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Pancuronium and Pancuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Rocuronium and Rocuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Pipecuronium (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Pancuronium and Pancuronium (Compound) resembles Rocuronium (Compound) and Rocuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Vecuronium and Vecuronium (Compound) resembles Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan (Compound) upregulates NOTCH1 (Gene) and NOTCH1 (Gene) is upregulated by Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Pancuronium and Pancuronium (Compound) resembles Vecuronium (Compound) and Vecuronium (Compound) resembles Pipecuronium (Compound)
Irinotecan (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)