DDInter1838 DDInter1397
Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) binds {v} (Gene) SLC6A4
SLC6A4 {u} (Gene) is bound by {v} (Compound) Paroxetine
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Chloramphenicol
Chloramphenicol {u} (Compound) upregulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Bromfenac {u} (Compound) upregulates {v} (Gene) DDX10
DDX10 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Bromfenac {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Duloxetine
Duloxetine {u} (Compound) palliates {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desvenlafaxine
Desvenlafaxine {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Tositumomab {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Topotecan {u} (Compound) downregulates {v} (Gene) AARS
AARS {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tositumomab {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Deferiprone {u} (Compound) downregulates {v} (Gene) HSPA8
HSPA8 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tositumomab {u} may lead to a major life threatening interaction when taken with {v} Cladribine
Cladribine {u} (Compound) binds {v} (Gene) PNP
PNP {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tositumomab {u} may lead to a major life threatening interaction when taken with {v} Deferiprone
Deferiprone {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Paroxetine (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Paroxetine (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) upregulates DDX10 (Gene) and DDX10 (Gene) is downregulated by Paroxetine (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Paroxetine (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) palliates endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan (Compound) downregulates AARS (Gene) and AARS (Gene) is upregulated by Paroxetine (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Deferiprone and Deferiprone (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Paroxetine (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Cladribine and Cladribine (Compound) binds PNP (Gene) and PNP (Gene) is downregulated by Paroxetine (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Deferiprone and Deferiprone (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Paroxetine (Compound)