DDInter458 DDInter1943
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are currently being researched for use in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage. Though this research is so far inconclusive, vitamin E remains a popular supplement and is generally considered safe by the FDA[FDA Label].
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is bound by {v} (Compound) Vitamin E
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Vitamin E
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is downregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Cyclosporine {u} (Compound) causes {v} (Side Effect) Atrophy
Atrophy {u} (Side Effect) is caused by {v} (Compound) Phylloquinone
Phylloquinone {u} (Compound) resembles {v} (Compound) Vitamin E
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Phylloquinone
Phylloquinone {u} (Compound) resembles {v} (Compound) Vitamin E
Cyclosporine {u} (Compound) causes {v} (Side Effect) Atrophy
Atrophy {u} (Side Effect) is caused by {v} (Compound) Betamethasone
Betamethasone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Vitamin E
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} may cause a minor interaction that can limit clinical effects when taken with {v} Vitamin E
Cyclosporine {u} (Compound) downregulates {v} (Gene) CCDC86
CCDC86 {u} (Gene) is regulated by {v} (Gene) CDK6
CDK6 {u} (Gene) is upregulated by {v} (Compound) Vitamin E
Cyclosporine {u} (Compound) upregulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is downregulated by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vitamin E
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is bound by Vitamin E (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Vitamin E (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Betamethasone (Compound) and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Cyclosporine (Compound) causes Atrophy (Side Effect) and Atrophy (Side Effect) is caused by Phylloquinone (Compound) and Phylloquinone (Compound) resembles Vitamin E (Compound)
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Phylloquinone (Compound) and Phylloquinone (Compound) resembles Vitamin E (Compound)
Cyclosporine (Compound) causes Atrophy (Side Effect) and Atrophy (Side Effect) is caused by Betamethasone (Compound) and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by NQO1 (Gene) and NQO1 (Gene) is bound by Vitamin E (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Cyclosporine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is regulated by CDK6 (Gene) and CDK6 (Gene) is upregulated by Vitamin E (Compound)
Cyclosporine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E