DDInter1489 DDInter1473
Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line.
Pipecuronium is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent.
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Rocuronium
Rocuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} (Compound) causes {v} (Side Effect) Flushing
Flushing {u} (Side Effect) is caused by {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Vecuronium
Vecuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Pancuronium
Pancuronium {u} (Compound) binds {v} (Gene) CHRNB1
CHRNB1 {u} (Gene) is bound by {v} (Compound) Pipecuronium
Polymyxin B {u} may lead to a major life threatening interaction when taken with {v} Rocuronium
Rocuronium {u} (Compound) binds {v} (Gene) CHRNB1
CHRNB1 {u} (Gene) is bound by {v} (Compound) Pipecuronium
Polymyxin B {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Vancomycin
Vancomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pancuronium
Pancuronium {u} (Compound) resembles {v} (Compound) Pipecuronium
Polymyxin B may lead to a major life threatening interaction when taken with Pancuronium and Pancuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Rocuronium and Rocuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Pancuronium and Pancuronium (Compound) resembles Rocuronium (Compound) and Rocuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Vecuronium and Vecuronium (Compound) resembles Pancuronium (Compound) and Pancuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Pancuronium and Pancuronium (Compound) resembles Vecuronium (Compound) and Vecuronium (Compound) resembles Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Pancuronium and Pancuronium (Compound) binds CHRNB1 (Gene) and CHRNB1 (Gene) is bound by Pipecuronium (Compound)
Polymyxin B may lead to a major life threatening interaction when taken with Rocuronium and Rocuronium (Compound) binds CHRNB1 (Gene) and CHRNB1 (Gene) is bound by Pipecuronium (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium and Pancuronium (Compound) resembles Pipecuronium (Compound)