DDInter1853 DDInter1224
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging activities. It has been used in dermatology for many years to treat various skin conditions ranging from acne to wrinkles [A257474,A258185] and activates nuclear receptors to regulate epithelial cell growth and differentiation.[A257474,A257629,A257609] Tretinoin is given orally to treat acute promyelocytic leukemia and topically to treat skin conditions such as acne.[L45389,L34869,L45384]
Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines. Minocycline was granted FDA approval on 30 June 1971.
Tretinoin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) is bound by {v} (Compound) Minocycline
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Minocycline
Tretinoin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) interacts with {v} (Gene) CASP1
CASP1 {u} (Gene) is bound by {v} (Compound) Minocycline
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Demeclocycline
Demeclocycline {u} (Compound) resembles {v} (Compound) Minocycline
Tretinoin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Doxycycline
Doxycycline {u} (Compound) resembles {v} (Compound) Minocycline
Tretinoin {u} (Compound) resembles {v} (Compound) Isotretinoin
Isotretinoin {u} may lead to a major life threatening interaction when taken with {v} Demeclocycline
Demeclocycline {u} (Compound) resembles {v} (Compound) Minocycline
Tretinoin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) regulates {v} (Gene) CYCS
CYCS {u} (Gene) is bound by {v} (Compound) Minocycline
Tretinoin {u} (Compound) downregulates {v} (Gene) AKT1
AKT1 {u} (Gene) interacts with {v} (Gene) VEGFA
VEGFA {u} (Gene) is bound by {v} (Compound) Minocycline
Tretinoin {u} (Compound) upregulates {v} (Gene) IL1B
IL1B {u} (Gene) is upregulated by {v} (Compound) Methotrexate
Methotrexate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Minocycline
Tretinoin {u} (Compound) resembles {v} (Compound) Acitretin
Acitretin {u} may lead to a major life threatening interaction when taken with {v} Oxytetracycline
Oxytetracycline {u} (Compound) resembles {v} (Compound) Minocycline
Tretinoin (Compound) upregulates IL1B (Gene) and IL1B (Gene) is bound by Minocycline (Compound)
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Minocycline
Tretinoin (Compound) upregulates IL1B (Gene) and IL1B (Gene) interacts with CASP1 (Gene) and CASP1 (Gene) is bound by Minocycline (Compound)
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Tretinoin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Doxycycline (Compound) and Doxycycline (Compound) resembles Minocycline (Compound)
Tretinoin (Compound) resembles Isotretinoin (Compound) and Isotretinoin may lead to a major life threatening interaction when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Tretinoin (Compound) upregulates IL1B (Gene) and IL1B (Gene) regulates CYCS (Gene) and CYCS (Gene) is bound by Minocycline (Compound)
Tretinoin (Compound) downregulates AKT1 (Gene) and AKT1 (Gene) interacts with VEGFA (Gene) and VEGFA (Gene) is bound by Minocycline (Compound)
Tretinoin (Compound) upregulates IL1B (Gene) and IL1B (Gene) is upregulated by Methotrexate (Compound) and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Minocycline
Tretinoin (Compound) resembles Acitretin (Compound) and Acitretin may lead to a major life threatening interaction when taken with Oxytetracycline and Oxytetracycline (Compound) resembles Minocycline (Compound)