DDInter535 DDInter907
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Diazoxide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Iloperidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Diarrhoea
Diarrhoea {u} (Side Effect) is caused by {v} (Compound) Gefitinib
Gefitinib {u} (Compound) resembles {v} (Compound) Iloperidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloperidone
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Iloperidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Paliperidone
Paliperidone {u} (Compound) resembles {v} (Compound) Iloperidone
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Nateglinide
Nateglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iloperidone
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} may lead to a major life threatening interaction when taken with {v} Cisapride
Cisapride {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Leukopenia
Leukopenia {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Iloperidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Cataract
Cataract {u} (Side Effect) is caused by {v} (Compound) Mefloquine
Mefloquine {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Diazoxide {u} (Compound) causes {v} (Side Effect) Haemoglobin decreased
Haemoglobin decreased {u} (Side Effect) is caused by {v} (Compound) Crizotinib
Crizotinib {u} may lead to a major life threatening interaction when taken with {v} Iloperidone
Diazoxide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Iloperidone (Compound)
Diazoxide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Gefitinib (Compound) and Gefitinib (Compound) resembles Iloperidone (Compound)
Diazoxide (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Iloperidone (Compound)
Diazoxide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Paliperidone (Compound) and Paliperidone (Compound) resembles Iloperidone (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Nateglinide (Compound) and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when taken with Iloperidone
Diazoxide (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Iloperidone
Diazoxide (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Mefloquine (Compound) and Mefloquine may lead to a major life threatening interaction when taken with Iloperidone
Diazoxide (Compound) causes Haemoglobin decreased (Side Effect) and Haemoglobin decreased (Side Effect) is caused by Crizotinib (Compound) and Crizotinib may lead to a major life threatening interaction when taken with Iloperidone