DDInter1729 DDInter965
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent.
Sulindac {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Amiloride
Amiloride {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Sulindac {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Nabumetone
Nabumetone {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Sulindac {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Triamterene
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Triamterene
Triamterene {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iothalamic acid
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) Cisplatin
Cisplatin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is upregulated by {v} (Compound) Kanamycin
Kanamycin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Sulindac {u} (Compound) palliates {v} (Disease) osteoarthritis
osteoarthritis {u} (Disease) is palliated by {v} (Compound) Ketoprofen
Ketoprofen {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Sulindac {u} (Compound) is included by {v} (Pharmacologic Class) Nonsteroidal Anti-inflammatory Compounds
Nonsteroidal Anti-inflammatory Compounds {u} (Pharmacologic Class) includes {v} (Compound) Oxaprozin
Oxaprozin {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Sulindac {u} (Compound) binds {v} (Gene) PTGS2
PTGS2 {u} (Gene) is bound by {v} (Compound) and {u} (Gene) is upregulated by {v} (Compound) Sulfasalazine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Iothalamic acid
Sulindac (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Amiloride (Compound) and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Sulindac (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Nabumetone (Compound) and Nabumetone may lead to a major life threatening interaction when taken with Iothalamic acid
Sulindac (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Triamterene (Compound) and Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Triamterene (Compound) and Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Cisplatin (Compound) and Cisplatin may lead to a major life threatening interaction when taken with Iothalamic acid
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Kanamycin (Compound) and Kanamycin may lead to a major life threatening interaction when taken with Iothalamic acid
Sulindac (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Ketoprofen (Compound) and Ketoprofen may lead to a major life threatening interaction when taken with Iothalamic acid
Sulindac (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) and Nonsteroidal Anti-inflammatory Compounds (Pharmacologic Class) includes Oxaprozin (Compound) and Oxaprozin may lead to a major life threatening interaction when taken with Iothalamic acid
Sulindac (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is bound by Sulfasalazine (Compound) and PTGS2 (Gene) is upregulated by Sulfasalazine (Compound) and Sulfasalazine may lead to a major life threatening interaction when taken with Iothalamic acid