DDInter298 DDInter783
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Fosphenytoin
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Fosphenytoin
Carboplatin {u} (Compound) treats {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Doxapram
Doxapram {u} (Compound) resembles {v} (Compound) Fosphenytoin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Clopidogrel
Clopidogrel {u} may cause a minor interaction that can limit clinical effects when taken with {v} Fosphenytoin
Carboplatin {u} (Compound) treats {v} (Disease) bone cancer
bone cancer {u} (Disease) is associated with {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Fosphenytoin
Carboplatin {u} (Compound) causes {v} (Side Effect) Infection
Infection {u} (Side Effect) is caused by {v} (Compound) Afatinib
Afatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Carboplatin {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Prednisone
Prednisone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Carboplatin {u} (Compound) binds {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Cisplatin
Cisplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Carboplatin {u} (Compound) treats {v} (Disease) brain cancer
brain cancer {u} (Disease) is palliated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fosphenytoin
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Fosphenytoin (Compound)
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Modafinil (Compound) and Modafinil (Compound) resembles Fosphenytoin (Compound)
Carboplatin (Compound) treats esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Doxapram (Compound) and Doxapram (Compound) resembles Fosphenytoin (Compound)
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Clopidogrel (Compound) and Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Fosphenytoin
Carboplatin (Compound) treats bone cancer (Disease) and bone cancer (Disease) is associated with CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Carboplatin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Afatinib (Compound) and Afatinib may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Carboplatin (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Carboplatin (Compound) binds GSTM1 (Gene) and GSTM1 (Gene) is bound by Cisplatin (Compound) and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin
Carboplatin (Compound) treats brain cancer (Disease) and brain cancer (Disease) is palliated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin