DDInter1158 DDInter98
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver.
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Mesalazine {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Diltiazem
Diltiazem {u} (Compound) resembles {v} (Compound) Anisindione
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mercaptopurine
Mercaptopurine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Mesalazine {u} (Compound) causes {v} (Side Effect) Rash pustular
Rash pustular {u} (Side Effect) is caused by {v} (Compound) Erlotinib
Erlotinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Mesalazine {u} (Compound) causes {v} (Side Effect) Bladder pain
Bladder pain {u} (Side Effect) is caused by {v} (Compound) Chenodeoxycholic acid
Chenodeoxycholic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exenatide
Exenatide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Anisindione
Mesalazine {u} (Compound) causes {v} (Side Effect) Discomfort
Discomfort {u} (Side Effect) is caused by {v} (Compound) Simvastatin
Simvastatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} (Compound) resembles {v} (Compound) Sulfasalazine
Sulfasalazine {u} may lead to a major life threatening interaction when taken with {v} Anisindione
Mesalazine {u} (Compound) causes {v} (Side Effect) Musculoskeletal stiffness
Musculoskeletal stiffness {u} (Side Effect) is caused by {v} (Compound) Bicalutamide
Bicalutamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Anisindione
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Ibuprofen {u} may lead to a major life threatening interaction when taken with {v} Anisindione
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a minor interaction that can limit clinical effects when taken with Anisindione
Mesalazine (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Diltiazem (Compound) and Diltiazem (Compound) resembles Anisindione (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Mesalazine (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Erlotinib (Compound) and Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Mesalazine (Compound) causes Bladder pain (Side Effect) and Bladder pain (Side Effect) is caused by Chenodeoxycholic acid (Compound) and Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Mesalazine (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Simvastatin (Compound) and Simvastatin may cause a minor interaction that can limit clinical effects when taken with Anisindione
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine (Compound) resembles Sulfasalazine (Compound) and Sulfasalazine may lead to a major life threatening interaction when taken with Anisindione
Mesalazine (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Bicalutamide (Compound) and Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Anisindione
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead to a major life threatening interaction when taken with Anisindione