DDInter458 DDInter1202
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Metronidazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Tinidazole
Tinidazole {u} (Compound) resembles {v} (Compound) Metronidazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Encephalopathy
Encephalopathy {u} (Side Effect) is caused by {v} (Compound) Ofloxacin
Ofloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Mental disorder
Mental disorder {u} (Side Effect) is caused by {v} (Compound) Atomoxetine
Atomoxetine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dyspepsia
Dyspepsia {u} (Side Effect) is caused by {v} (Compound) Tinidazole
Tinidazole {u} (Compound) resembles {v} (Compound) Metronidazole
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Saquinavir
Saquinavir {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Bacterial infection
Bacterial infection {u} (Side Effect) is caused by {v} (Compound) Cyclophosphamide
Cyclophosphamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Cyclosporine {u} (Compound) causes {v} (Side Effect) Bacterial infection
Bacterial infection {u} (Side Effect) is caused by {v} (Compound) Ixabepilone
Ixabepilone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metronidazole
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Metronidazole (Compound)
Cyclosporine (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Metronidazole (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dextropropoxyphene (Compound) and Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tinidazole (Compound) and Tinidazole (Compound) resembles Metronidazole (Compound)
Cyclosporine (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Cyclosporine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Atomoxetine (Compound) and Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Cyclosporine (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Tinidazole (Compound) and Tinidazole (Compound) resembles Metronidazole (Compound)
Cyclosporine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Saquinavir (Compound) and Saquinavir may cause a minor interaction that can limit clinical effects when taken with Metronidazole
Cyclosporine (Compound) causes Bacterial infection (Side Effect) and Bacterial infection (Side Effect) is caused by Cyclophosphamide (Compound) and Cyclophosphamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole
Cyclosporine (Compound) causes Bacterial infection (Side Effect) and Bacterial infection (Side Effect) is caused by Ixabepilone (Compound) and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole