DDInter690 DDInter1197
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Diphenhydramine
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Clomipramine
Clomipramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is associated with {v} (Disease) prostate cancer
prostate cancer {u} (Disease) is palliated by {v} (Compound) Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Dopamine
Dopamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) GRIN3A
GRIN3A {u} (Gene) is bound by {v} (Compound) Tramadol
Tramadol {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) GRIN3A
GRIN3A {u} (Gene) is bound by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Ethanol {u} (Compound) binds {v} (Gene) CYP2E1
CYP2E1 {u} (Gene) is bound by {v} (Compound) Iloperidone
Iloperidone {u} may lead to a major life threatening interaction when taken with {v} Metoclopramide
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Diphenhydramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Ethanol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Cisapride (Compound) and Cisapride (Compound) resembles Metoclopramide (Compound)
Ethanol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Ethanol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is associated with prostate cancer (Disease) and prostate cancer (Disease) is palliated by Metoclopramide (Compound)
Ethanol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dopamine (Compound) and Dopamine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Ethanol (Compound) binds GRIN3A (Gene) and GRIN3A (Gene) is bound by Tramadol (Compound) and Tramadol may lead to a major life threatening interaction when taken with Metoclopramide
Ethanol (Compound) binds GRIN3A (Gene) and GRIN3A (Gene) is bound by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)
Ethanol (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Iloperidone (Compound) and Iloperidone may lead to a major life threatening interaction when taken with Metoclopramide