DDInter162 DDInter600
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury. Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Baclofen {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Baclofen {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Toremifene
Toremifene {u} (Compound) resembles {v} (Compound) Doxylamine
Baclofen {u} (Compound) causes {v} (Side Effect) Anxiety
Anxiety {u} (Side Effect) is caused by {v} (Compound) Doxepin
Doxepin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Baclofen {u} (Compound) causes {v} (Side Effect) Miosis
Miosis {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Baclofen {u} (Compound) causes {v} (Side Effect) Orthostatic hypotension
Orthostatic hypotension {u} (Side Effect) is caused by {v} (Compound) Imipramine
Imipramine {u} (Compound) resembles {v} (Compound) Doxylamine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) resembles {v} (Compound) Metyrosine
Metyrosine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Baclofen {u} (Compound) resembles {v} (Compound) Chlorpropamide
Chlorpropamide {u} (Compound) causes {v} (Side Effect) Pancytopenia
Pancytopenia {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Baclofen {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} (Compound) causes {v} (Side Effect) Decreased appetite
Decreased appetite {u} (Side Effect) is caused by {v} (Compound) Doxylamine
Baclofen {u} (Compound) binds {v} (Gene) SLC22A8
SLC22A8 {u} (Gene) is bound by {v} (Compound) Valproic acid
Valproic acid {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Baclofen {u} (Compound) binds {v} (Gene) GABBR1
GABBR1 {u} (Gene) is bound by {v} (Compound) Vigabatrin
Vigabatrin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Doxylamine
Baclofen (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxylamine (Compound)
Baclofen (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Toremifene (Compound) and Toremifene (Compound) resembles Doxylamine (Compound)
Baclofen (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Doxepin (Compound) and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Baclofen (Compound) causes Miosis (Side Effect) and Miosis (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Baclofen (Compound) causes Orthostatic hypotension (Side Effect) and Orthostatic hypotension (Side Effect) is caused by Imipramine (Compound) and Imipramine (Compound) resembles Doxylamine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) resembles Metyrosine (Compound) and Metyrosine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Baclofen (Compound) resembles Chlorpropamide (Compound) and Chlorpropamide (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Doxylamine (Compound)
Baclofen (Compound) resembles Ibuprofen (Compound) and Ibuprofen (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Doxylamine (Compound)
Baclofen (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Valproic acid (Compound) and Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Baclofen (Compound) binds GABBR1 (Gene) and GABBR1 (Gene) is bound by Vigabatrin (Compound) and Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine