DDInter484 DDInter833
Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein BCR-ABL. BCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the pathogenesis of CML and 15-30% of ALL cases.[A11377,A33432] Dasatinib also inhibits a spectrum of kinases involved in cancer, including several SRC-family kinases. Unlike [imatinib], another tyrosine kinase used for the treatment of CML and Ph-positive ALL, dasatinib inhibits the active and inactive conformations of the ABL
Glycerol phenylbutyrate is a nitrogen-binding agent. Chemically, it is a triglyceride in which three molecules of phenylbutyrate are linked to a glycerol backbone. FDA approved on February 1, 2013.
Dasatinib {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Phenylbutazone
Phenylbutazone {u} (Compound) resembles {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Modafinil
Modafinil {u} (Compound) resembles {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Modafinil
Modafinil {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextropropoxyphene
Dextropropoxyphene {u} (Compound) resembles {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Methadone
Methadone {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} (Compound) downregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} (Compound) downregulates {v} (Gene) PCNA
PCNA {u} (Gene) is downregulated by {v} (Compound) Alverine
Alverine {u} (Compound) resembles {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Colchicine
Colchicine {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Dasatinib {u} may lead to a major life threatening interaction when taken with {v} Amisulpride
Amisulpride {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Glycerol phenylbutyrate
Dasatinib (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Dasatinib (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Dasatinib (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Alverine (Compound) and Alverine (Compound) resembles Glycerol phenylbutyrate (Compound)
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Colchicine and Colchicine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)
Dasatinib may lead to a major life threatening interaction when taken with Amisulpride and Amisulpride (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Glycerol phenylbutyrate (Compound)