DDInter542 DDInter1834
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) binds {v} (Gene) GPR35
GPR35 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) resembles {v} (Compound) Acenocoumarol
Acenocoumarol {u} (Compound) causes {v} (Side Effect) Urticaria
Urticaria {u} (Side Effect) is caused by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is associated with {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) is regulated by {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) binds {v} (Gene) VKORC1
VKORC1 {u} (Gene) interacts with {v} (Gene) PROCR
PROCR {u} (Gene) is downregulated by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) regulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) regulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Topiramate
Dicoumarol {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Topiramate
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Topiramate (Compound)
Dicoumarol (Compound) binds GPR35 (Gene) and GPR35 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Topiramate (Compound)
Dicoumarol (Compound) resembles Acenocoumarol (Compound) and Acenocoumarol (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Topiramate (Compound)
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) is associated with obesity (Disease) and obesity (Disease) is treated by Topiramate (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) is regulated by CA2 (Gene) and CA2 (Gene) is bound by Topiramate (Compound)
Dicoumarol (Compound) binds VKORC1 (Gene) and VKORC1 (Gene) interacts with PROCR (Gene) and PROCR (Gene) is downregulated by Topiramate (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) regulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Topiramate (Compound)
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) regulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Topiramate (Compound)
Dicoumarol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Topiramate (Compound)