DDInter154 DDInter45
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
A phenothiazine derivative that is used as an antipruritic.
Azelastine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Alimemazine
Azelastine {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Alimemazine
Azelastine {u} (Compound) downregulates {v} (Gene) PDHX
PDHX {u} (Gene) is downregulated by {v} (Compound) Alimemazine
Azelastine {u} (Compound) causes {v} (Side Effect) Agitation
Agitation {u} (Side Effect) is caused by {v} (Compound) Alimemazine
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Azelastine {u} (Compound) resembles {v} (Compound) Clozapine
Clozapine {u} may lead to a major life threatening interaction when taken with {v} Alimemazine
Azelastine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Orphenadrine
Orphenadrine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alimemazine
Azelastine {u} (Compound) upregulates {v} (Gene) FOXO4
FOXO4 {u} (Gene) is upregulated by {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Alimemazine
Azelastine {u} (Compound) downregulates {v} (Gene) PDHX
PDHX {u} (Gene) is downregulated by {v} (Compound) Chlorprothixene
Chlorprothixene {u} (Compound) resembles {v} (Compound) Alimemazine
Azelastine {u} (Compound) downregulates {v} (Gene) CDC45
CDC45 {u} (Gene) is downregulated by {v} (Compound) Promazine
Promazine {u} (Compound) resembles {v} (Compound) Alimemazine
Azelastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Alimemazine (Compound)
Azelastine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Alimemazine (Compound)
Azelastine (Compound) downregulates PDHX (Gene) and PDHX (Gene) is downregulated by Alimemazine (Compound)
Azelastine (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Alimemazine (Compound)
Azelastine (Compound) resembles Loxapine (Compound) and Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Azelastine (Compound) resembles Clozapine (Compound) and Clozapine may lead to a major life threatening interaction when taken with Alimemazine
Azelastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Azelastine (Compound) upregulates FOXO4 (Gene) and FOXO4 (Gene) is upregulated by Promazine (Compound) and Promazine (Compound) resembles Alimemazine (Compound)
Azelastine (Compound) downregulates PDHX (Gene) and PDHX (Gene) is downregulated by Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Alimemazine (Compound)
Azelastine (Compound) downregulates CDC45 (Gene) and CDC45 (Gene) is downregulated by Promazine (Compound) and Promazine (Compound) resembles Alimemazine (Compound)