DDInter1707 DDInter1016
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension. Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243, L6187]
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone
Spironolactone {u} (Compound) resembles {v} (Compound) Dydrogesterone
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Spironolactone {u} (Compound) treats {v} (Disease) dilated cardiomyopathy
Spironolactone {u} (Compound) binds {v} (Gene) PGR
Spironolactone {u} (Compound) upregulates {v} (Gene) WIF1
Spironolactone {u} (Compound) is included by {v} (Pharmacologic Class) Aldosterone Antagonists
Spironolactone {u} (Compound) downregulates {v} (Gene) GNAS
Spironolactone {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Spironolactone {u} may cause a minor interaction that can limit clinical effects when taken with {v} Warfarin
Spironolactone (Compound) resembles Testosterone (Compound)
Spironolactone (Compound) resembles Dydrogesterone (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone
Spironolactone (Compound) treats dilated cardiomyopathy (Disease)
Spironolactone (Compound) binds PGR (Gene)
Spironolactone (Compound) upregulates WIF1 (Gene)
Spironolactone (Compound) is included by Aldosterone Antagonists (Pharmacologic Class)
Spironolactone (Compound) downregulates GNAS (Gene)
Spironolactone (Compound) causes Feeling abnormal (Side Effect)
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfarin