DDInter1233 DDInter682
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Estrone
Mitotane {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Estrone
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Equilin
Equilin {u} (Compound) resembles {v} (Compound) Estrone
Mitotane {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Estramustine
Estramustine {u} (Compound) resembles {v} (Compound) Estrone
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Estrone
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) resembles {v} (Compound) Miconazole
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Estrone
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dezocine
Dezocine {u} (Compound) resembles {v} (Compound) Estrone
Mitotane {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Levorphanol
Levorphanol {u} (Compound) resembles {v} (Compound) Estrone
Mitotane {u} (Compound) resembles {v} (Compound) Butoconazole
Butoconazole {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Estrone
Mitotane {u} (Compound) binds {v} (Gene) SHBG
SHBG {u} (Gene) is bound by {v} (Compound) Ethinylestradiol
Ethinylestradiol {u} (Compound) resembles {v} (Compound) Estrone
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Estrone (Compound)
Mitotane (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Estrone (Compound)
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Equilin (Compound) and Equilin (Compound) resembles Estrone (Compound)
Mitotane (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Estramustine (Compound) and Estramustine (Compound) resembles Estrone (Compound)
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Estrone (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) resembles Miconazole (Compound) and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Estrone
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dezocine and Dezocine (Compound) resembles Estrone (Compound)
Mitotane (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Levorphanol (Compound) and Levorphanol (Compound) resembles Estrone (Compound)
Mitotane (Compound) resembles Butoconazole (Compound) and Butoconazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Estrone (Compound)
Mitotane (Compound) binds SHBG (Gene) and SHBG (Gene) is bound by Ethinylestradiol (Compound) and Ethinylestradiol (Compound) resembles Estrone (Compound)