DDInter217 DDInter1397
Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} (Compound) causes {v} (Side Effect) Anaphylactoid reaction
Anaphylactoid reaction {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ketorolac
Ketorolac {u} (Compound) upregulates {v} (Gene) TSC22D3
TSC22D3 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Icosapent
Icosapent {u} (Compound) binds {v} (Gene) FADS1
FADS1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Indomethacin
Indomethacin {u} (Compound) downregulates {v} (Gene) TIMELESS
TIMELESS {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Icosapent
Icosapent {u} (Compound) downregulates {v} (Gene) HERPUD1
HERPUD1 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bromfenac
Bromfenac {u} (Compound) upregulates {v} (Gene) DDX10
DDX10 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clomipramine
Clomipramine {u} (Compound) palliates {v} (Disease) panic disorder
panic disorder {u} (Disease) is palliated by {v} (Compound) Paroxetine
Bivalirudin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Sunitinib
Sunitinib {u} (Compound) binds {v} (Gene) PRPF4
PRPF4 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Bivalirudin {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP2C8
CYP2C8 {u} (Gene) is bound by {v} (Compound) Paroxetine
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) causes Anaphylactoid reaction (Side Effect) and Anaphylactoid reaction (Side Effect) is caused by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upregulated by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Icosapent and Icosapent (Compound) binds FADS1 (Gene) and FADS1 (Gene) is upregulated by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) downregulates TIMELESS (Gene) and TIMELESS (Gene) is downregulated by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Icosapent and Icosapent (Compound) downregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) upregulates DDX10 (Gene) and DDX10 (Gene) is downregulated by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Paroxetine (Compound)
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) binds PRPF4 (Gene) and PRPF4 (Gene) is downregulated by Paroxetine (Compound)
Bivalirudin may lead to a major life threatening interaction when taken with Warfarin and Warfarin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Paroxetine (Compound)