DDInter535 DDInter1442
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Diazoxide {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Diazoxide {u} (Compound) causes {v} (Side Effect) Dermatitis
Dermatitis {u} (Side Effect) is caused by {v} (Compound) Primidone
Primidone {u} (Compound) resembles {v} (Compound) Phenobarbital
Diazoxide {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Methsuximide
Methsuximide {u} (Compound) resembles {v} (Compound) Phenobarbital
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Phenobarbital
Diazoxide {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Letrozole
Letrozole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenobarbital
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Repaglinide
Repaglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is associated with {v} (Disease) epilepsy syndrome
epilepsy syndrome {u} (Disease) is treated by {v} (Compound) Phenobarbital
Diazoxide {u} (Compound) binds {v} (Gene) CA1
CA1 {u} (Gene) is bound by {v} (Compound) Imatinib
Imatinib {u} may lead to a major life threatening interaction when taken with {v} Phenobarbital
Diazoxide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) is bound by {v} (Compound) Nilotinib
Nilotinib {u} may lead to a major life threatening interaction when taken with {v} Phenobarbital
Diazoxide {u} (Compound) binds {v} (Gene) ATP1A1
ATP1A1 {u} (Gene) is upregulated by {v} (Compound) Betamethasone
Betamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Phenobarbital
Diazoxide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Phenobarbital (Compound)
Diazoxide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Primidone (Compound) and Primidone (Compound) resembles Phenobarbital (Compound)
Diazoxide (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Methsuximide (Compound) and Methsuximide (Compound) resembles Phenobarbital (Compound)
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Phenobarbital (Compound)
Diazoxide (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Letrozole (Compound) and Letrozole may cause a minor interaction that can limit clinical effects when taken with Phenobarbital
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Repaglinide (Compound) and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is associated with epilepsy syndrome (Disease) and epilepsy syndrome (Disease) is treated by Phenobarbital (Compound)
Diazoxide (Compound) binds CA1 (Gene) and CA1 (Gene) is bound by Imatinib (Compound) and Imatinib may lead to a major life threatening interaction when taken with Phenobarbital
Diazoxide (Compound) binds CA2 (Gene) and CA2 (Gene) is bound by Nilotinib (Compound) and Nilotinib may lead to a major life threatening interaction when taken with Phenobarbital
Diazoxide (Compound) binds ATP1A1 (Gene) and ATP1A1 (Gene) is upregulated by Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital