DDInter1647 DDInter1651
Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analogue, scopolamine can antagonize muscarinic acetylcholine receptors (mAChRs) in the central nervous system and throughout the body, inducing several therapeutic and adverse effects related to alteration of parasympathetic nervous system and cholinergic signalling.[A228758, L31578] Due to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a transdermal delivery system, Scopoderm TTS®, in 1981.[A228423,
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system . Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
Scopolamine {u} (Compound) resembles {v} (Compound) Homatropine Methylbromide
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hyoscyamine
Scopolamine {u} (Compound) resembles {v} (Compound) Methylscopolamine bromide
Scopolamine {u} (Compound) binds {v} (Gene) CHRM4
Scopolamine {u} (Compound) upregulates {v} (Gene) MCOLN1
Scopolamine {u} (Compound) causes {v} (Side Effect) Photophobia
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metolazone
Scopolamine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Phenelzine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nadolol
Scopolamine {u} may lead to a major life threatening interaction when taken with {v} Potassium chloride
Scopolamine (Compound) resembles Homatropine Methylbromide (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Scopolamine (Compound) resembles Methylscopolamine bromide (Compound)
Scopolamine (Compound) binds CHRM4 (Gene)
Scopolamine (Compound) upregulates MCOLN1 (Gene)
Scopolamine (Compound) causes Photophobia (Side Effect)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Metolazone
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Phenelzine
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol
Scopolamine may lead to a major life threatening interaction when taken with Potassium chloride