DDInter154 DDInter1239
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
Azelastine {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is downregulated by {v} (Compound) Molindone
Azelastine {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Molindone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Molindone
Azelastine {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) regulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Molindone
Azelastine {u} (Compound) causes {v} (Side Effect) Amenorrhoea
Amenorrhoea {u} (Side Effect) is caused by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Molindone
Azelastine {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) is bound by {v} (Compound) Molindone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) is downregulated by {v} (Compound) Molindone
Azelastine {u} (Compound) downregulates {v} (Gene) ENOPH1
ENOPH1 {u} (Gene) is downregulated by {v} (Compound) Ifosfamide
Ifosfamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Molindone
Azelastine {u} (Compound) resembles {v} (Compound) Clemastine
Clemastine {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Molindone
Azelastine {u} (Compound) causes {v} (Side Effect) Dry mouth
Dry mouth {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Molindone
Azelastine (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Molindone (Compound)
Azelastine (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Molindone (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Azelastine (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) regulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Molindone (Compound)
Azelastine (Compound) causes Amenorrhoea (Side Effect) and Amenorrhoea (Side Effect) is caused by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Azelastine (Compound) resembles Loxapine (Compound) and Loxapine (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Molindone (Compound)
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine (Compound) downregulates CYCS (Gene) and CYCS (Gene) is downregulated by Molindone (Compound)
Azelastine (Compound) downregulates ENOPH1 (Gene) and ENOPH1 (Gene) is downregulated by Ifosfamide (Compound) and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Azelastine (Compound) resembles Clemastine (Compound) and Clemastine (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Molindone (Compound)
Azelastine (Compound) causes Dry mouth (Side Effect) and Dry mouth (Side Effect) is caused by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Molindone