DDInter1705 DDInter1376
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Sparfloxacin {u} (Compound) resembles {v} (Compound) Lomefloxacin
Sparfloxacin {u} (Compound) binds {v} (Gene) SLC22A5
Sparfloxacin {u} (Compound) upregulates {v} (Gene) KCTD5
Sparfloxacin {u} (Compound) downregulates {v} (Gene) PKIG
Sparfloxacin {u} (Compound) causes {v} (Side Effect) Atrial flutter
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Temozolomide
Sparfloxacin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Paclitaxel
Sparfloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zinc sulfate
Sparfloxacin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ibuprofen
Sparfloxacin {u} may lead to a major life threatening interaction when taken with {v} Vandetanib
Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Sparfloxacin (Compound) binds SLC22A5 (Gene)
Sparfloxacin (Compound) upregulates KCTD5 (Gene)
Sparfloxacin (Compound) downregulates PKIG (Gene)
Sparfloxacin (Compound) causes Atrial flutter (Side Effect)
Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Temozolomide
Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Paclitaxel
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Zinc sulfate
Sparfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Sparfloxacin may lead to a major life threatening interaction when taken with Vandetanib