DDInter1236 DDInter255
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Modafinil {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Modafinil {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Modafinil {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Modafinil {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) MGST2
MGST2 {u} (Gene) is bound by {v} (Compound) Busulfan
Modafinil {u} (Compound) resembles {v} (Compound) Fentanyl
Fentanyl {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Modafinil {u} (Compound) resembles {v} (Compound) Fentanyl
Fentanyl {u} (Compound) causes {v} (Side Effect) Dermatitis bullous
Dermatitis bullous {u} (Side Effect) is caused by {v} (Compound) Busulfan
Modafinil {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is regulated by {v} (Gene) DUSP11
DUSP11 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Modafinil {u} (Compound) resembles {v} (Compound) Phenytoin
Phenytoin {u} (Compound) upregulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Modafinil {u} (Compound) resembles {v} (Compound) Carbamazepine
Carbamazepine {u} (Compound) downregulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Modafinil {u} (Compound) resembles {v} (Compound) Dextropropoxyphene
Dextropropoxyphene {u} (Compound) upregulates {v} (Gene) XBP1
XBP1 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Modafinil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Modafinil (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Busulfan (Compound)
Modafinil (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Modafinil (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by MGST2 (Gene) and MGST2 (Gene) is bound by Busulfan (Compound)
Modafinil (Compound) resembles Fentanyl (Compound) and Fentanyl (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Modafinil (Compound) resembles Fentanyl (Compound) and Fentanyl (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Busulfan (Compound)
Modafinil (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is regulated by DUSP11 (Gene) and DUSP11 (Gene) is upregulated by Busulfan (Compound)
Modafinil (Compound) resembles Phenytoin (Compound) and Phenytoin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Busulfan (Compound)
Modafinil (Compound) resembles Carbamazepine (Compound) and Carbamazepine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Busulfan (Compound)
Modafinil (Compound) resembles Dextropropoxyphene (Compound) and Dextropropoxyphene (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is downregulated by Busulfan (Compound)