DDInter1202 DDInter1676
Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Metronidazole {u} (Compound) resembles {v} (Compound) Tinidazole
Metronidazole {u} (Compound) binds {v} (Gene) CYP2C8
Metronidazole {u} (Compound) upregulates {v} (Gene) ZNF586
Metronidazole {u} (Compound) is included by {v} (Pharmacologic Class) Nitroimidazoles
Metronidazole {u} (Compound) causes {v} (Side Effect) Loss of libido
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Atomoxetine
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Tetrabenazine
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mycophenolate mofetil
Metronidazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Telbivudine
Metronidazole {u} may lead to a major life threatening interaction when taken with {v} Amprenavir
Metronidazole (Compound) resembles Tinidazole (Compound)
Metronidazole (Compound) binds CYP2C8 (Gene)
Metronidazole (Compound) upregulates ZNF586 (Gene)
Metronidazole (Compound) is included by Nitroimidazoles (Pharmacologic Class)
Metronidazole (Compound) causes Loss of libido (Side Effect)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Atomoxetine
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tetrabenazine
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine
Metronidazole may lead to a major life threatening interaction when taken with Amprenavir