DDInter1758 DDInter255
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Telithromycin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Telithromycin {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Telithromycin {u} (Compound) resembles {v} (Compound) Azithromycin
Azithromycin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Telithromycin {u} (Compound) resembles {v} (Compound) Azithromycin
Azithromycin {u} (Compound) upregulates {v} (Gene) SLC35A1
SLC35A1 {u} (Gene) is upregulated by {v} (Compound) Busulfan
Telithromycin {u} (Compound) resembles {v} (Compound) Dirithromycin
Dirithromycin {u} (Compound) upregulates {v} (Gene) WRB
WRB {u} (Gene) is downregulated by {v} (Compound) Busulfan
Telithromycin {u} (Compound) resembles {v} (Compound) Erythromycin
Erythromycin {u} (Compound) causes {v} (Side Effect) Arrhythmia
Arrhythmia {u} (Side Effect) is caused by {v} (Compound) Busulfan
Telithromycin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Busulfan
Telithromycin {u} (Compound) resembles {v} (Compound) Dirithromycin
Dirithromycin {u} (Compound) downregulates {v} (Gene) TIMM9
TIMM9 {u} (Gene) is downregulated by {v} (Compound) Busulfan
Telithromycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metronidazole
Metronidazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Busulfan
Telithromycin {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) AURKB
AURKB {u} (Gene) is upregulated by {v} (Compound) Busulfan
Telithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Telithromycin (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Telithromycin (Compound) resembles Azithromycin (Compound) and Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Telithromycin (Compound) resembles Azithromycin (Compound) and Azithromycin (Compound) upregulates SLC35A1 (Gene) and SLC35A1 (Gene) is upregulated by Busulfan (Compound)
Telithromycin (Compound) resembles Dirithromycin (Compound) and Dirithromycin (Compound) upregulates WRB (Gene) and WRB (Gene) is downregulated by Busulfan (Compound)
Telithromycin (Compound) resembles Erythromycin (Compound) and Erythromycin (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Busulfan (Compound)
Telithromycin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates DLD (Gene) and DLD (Gene) is downregulated by Busulfan (Compound)
Telithromycin (Compound) resembles Dirithromycin (Compound) and Dirithromycin (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Busulfan (Compound)
Telithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Busulfan (Compound)
Telithromycin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates AURKB (Gene) and AURKB (Gene) is upregulated by Busulfan (Compound)