DDInter1095 DDInter856
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or [hydrochlorothiazide]. Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide.[L7423,L7426] Patients taking losartan should have their renal function and potassium levels monitored. Losartan was granted FDA approval on 14 April 1995.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Losartan {u} (Compound) resembles {v} (Compound) Candesartan
Losartan {u} (Compound) resembles {v} (Compound) Eprosartan
Losartan {u} (Compound) treats {v} (Disease) coronary artery disease
Losartan {u} (Compound) binds {v} (Gene) UGT2B7
Losartan {u} (Compound) upregulates {v} (Gene) RRS1
Losartan {u} (Compound) is included by {v} (Pharmacologic Class) Angiotensin 2 Receptor Antagonists
Losartan {u} (Compound) downregulates {v} (Gene) GNAS
Losartan {u} (Compound) causes {v} (Side Effect) Cataract
Losartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fludrocortisone
Losartan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Insulin glargine
Losartan (Compound) resembles Candesartan (Compound)
Losartan (Compound) resembles Eprosartan (Compound)
Losartan (Compound) treats coronary artery disease (Disease)
Losartan (Compound) binds UGT2B7 (Gene)
Losartan (Compound) upregulates RRS1 (Gene)
Losartan (Compound) is included by Angiotensin 2 Receptor Antagonists (Pharmacologic Class)
Losartan (Compound) downregulates GNAS (Gene)
Losartan (Compound) causes Cataract (Side Effect)
Losartan may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone
Losartan may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine