DDInter1355 DDInter1610
Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride moieties. Due to this chemical moiety, oxaliplatin readily undergoes non-enzymatic biotransformation, thus complicating oxaliplatin's pharmacokinetics. Like most platinum-based compounds, oxaliplatin's mechanism of action is primarily through DNA damage through DNA crosslinking, particularly intrastrand and interstrand crosslinking. However, due to the structure of oxaliplatin, its adducts make the binding of mismatch repair protein to DNA harder compared to cisplatin or carboplatin's adducts, resulting in greater cytotoxic effects. The
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Oxaliplatin {u} (Compound) binds {v} (Gene) CA4
CA4 {u} (Gene) is associated with {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is treated by {v} (Compound) Rivastigmine
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) regulates {v} (Gene) IFRD2
IFRD2 {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Oxaliplatin {u} (Compound) binds {v} (Gene) ABCC2
ABCC2 {u} (Gene) is upregulated by {v} (Disease) Alzheimer's disease
Alzheimer's disease {u} (Disease) is treated by {v} (Compound) Rivastigmine
Oxaliplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Oxaliplatin {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) is associated with {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Rivastigmine
Oxaliplatin {u} (Compound) binds {v} (Gene) SOD1
SOD1 {u} (Gene) regulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Rivastigmine
Oxaliplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Sulfamethoxazole {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Rivastigmine
Oxaliplatin {u} (Compound) binds {v} (Gene) SOD1
SOD1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Rivastigmine
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxaprozin
Oxaprozin {u} (Compound) causes {v} (Side Effect) Glossitis
Glossitis {u} (Side Effect) is caused by {v} (Compound) Rivastigmine
Oxaliplatin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfamethoxazole
Sulfamethoxazole {u} (Compound) causes {v} (Side Effect) Pruritus
Pruritus {u} (Side Effect) is caused by {v} (Compound) Rivastigmine
Oxaliplatin (Compound) binds CA4 (Gene) and CA4 (Gene) is associated with Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is treated by Rivastigmine (Compound)
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) regulates IFRD2 (Gene) and IFRD2 (Gene) is downregulated by Rivastigmine (Compound)
Oxaliplatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is upregulated by Alzheimer's disease (Disease) and Alzheimer's disease (Disease) is treated by Rivastigmine (Compound)
Oxaliplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Rivastigmine (Compound)
Oxaliplatin (Compound) binds NQO1 (Gene) and NQO1 (Gene) is associated with Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Rivastigmine (Compound)
Oxaliplatin (Compound) binds SOD1 (Gene) and SOD1 (Gene) regulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Rivastigmine (Compound)
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivastigmine (Compound)
Oxaliplatin (Compound) binds SOD1 (Gene) and SOD1 (Gene) interacts with STUB1 (Gene) and SOD1 (Gene) regulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Rivastigmine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Rivastigmine (Compound)
Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivastigmine (Compound)