DDInter499 DDInter1676
A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
Siponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought to play a role in suppressing the central nervous system inflammation that is associated with MS [FDA label]. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings. MS is one of the most common causes of neurological disability in young adults and is found to occur more frequently in women than in men.[A176474,L5792]
Denileukin diftitox {u} may cause a minor interaction that can limit clinical effects when taken with {v} Moxifloxacin
Denileukin diftitox {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Denileukin diftitox {u} may lead to a major life threatening interaction when taken with {v} Measles virus vaccine live attenuated
Denileukin diftitox may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Denileukin diftitox may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated