DDInter458 DDInter604
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as drospirenone exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be considered when assessing potential risks of hormonal contraceptive use.
Cyclosporine {u} (Compound) causes {v} (Side Effect) Uterine haemorrhage
Uterine haemorrhage {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Norethisterone
Norethisterone {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is regulated by {v} (Gene) AR
AR {u} (Gene) is bound by {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) FOXO3
FOXO3 {u} (Gene) is upregulated by {v} (Compound) Medrysone
Medrysone {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is downregulated by {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) downregulates {v} (Gene) PROS1
PROS1 {u} (Gene) is upregulated by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine {u} (Compound) downregulates {v} (Gene) HSPB1
HSPB1 {u} (Gene) is upregulated by {v} (Compound) Medrysone
Medrysone {u} (Compound) resembles {v} (Compound) Drospirenone
Cyclosporine (Compound) causes Uterine haemorrhage (Side Effect) and Uterine haemorrhage (Side Effect) is caused by Drospirenone (Compound)
Cyclosporine (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Hydrocortisone (Compound) and Hydrocortisone (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Norethisterone (Compound) and Norethisterone (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is regulated by AR (Gene) and AR (Gene) is bound by Drospirenone (Compound)
Cyclosporine (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Medrysone (Compound) and Medrysone (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) upregulates MYC (Gene) and MYC (Gene) is downregulated by Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) downregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Cyclosporine (Compound) downregulates HSPB1 (Gene) and HSPB1 (Gene) is upregulated by Medrysone (Compound) and Medrysone (Compound) resembles Drospirenone (Compound)