DDInter1704 DDInter1055
Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.[Label,L6373,L6376]
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Sotalol {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Sotalol {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Sotalol {u} (Compound) causes {v} (Side Effect) Cardiovascular disorder
Cardiovascular disorder {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Sotalol {u} (Compound) resembles {v} (Compound) Atenolol
Atenolol {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Sotalol {u} (Compound) resembles {v} (Compound) Ibutilide
Ibutilide {u} (Compound) causes {v} (Side Effect) Bradycardia
Bradycardia {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Sotalol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is associated with {v} (Disease) chronic obstructive pulmonary disease
chronic obstructive pulmonary disease {u} (Disease) is palliated by {v} (Compound) Levofloxacin
Sotalol {u} (Compound) binds {v} (Gene) KCNH2
KCNH2 {u} (Gene) interacts with {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Sotalol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) regulates {v} (Gene) CPVL
CPVL {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Sotalol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is regulated by {v} (Gene) RB1
RB1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Sotalol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sucralfate
Sucralfate {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Sotalol (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Levofloxacin (Compound)
Sotalol (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Sotalol (Compound) causes Cardiovascular disorder (Side Effect) and Cardiovascular disorder (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Sotalol (Compound) resembles Atenolol (Compound) and Atenolol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Sotalol (Compound) resembles Ibutilide (Compound) and Ibutilide (Compound) causes Bradycardia (Side Effect) and Bradycardia (Side Effect) is caused by Levofloxacin (Compound)
Sotalol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is associated with chronic obstructive pulmonary disease (Disease) and chronic obstructive pulmonary disease (Disease) is palliated by Levofloxacin (Compound)
Sotalol (Compound) binds KCNH2 (Gene) and KCNH2 (Gene) interacts with PRKACA (Gene) and PRKACA (Gene) is downregulated by Levofloxacin (Compound)
Sotalol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) regulates CPVL (Gene) and CPVL (Gene) is upregulated by Levofloxacin (Compound)
Sotalol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is regulated by RB1 (Gene) and RB1 (Gene) is downregulated by Levofloxacin (Compound)
Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Levofloxacin (Compound)