DDInter535 DDInter1239
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
Diazoxide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is downregulated by {v} (Compound) Molindone
Diazoxide {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Molindone
Diazoxide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is regulated by {v} (Gene) TSKU
TSKU {u} (Gene) is upregulated by {v} (Compound) Molindone
Diazoxide {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Molindone
Diazoxide {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Scopolamine
Scopolamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Molindone
Diazoxide {u} (Compound) resembles {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) causes {v} (Side Effect) Muscle spasms
Muscle spasms {u} (Side Effect) is caused by {v} (Compound) Molindone
Diazoxide {u} (Compound) binds {v} (Gene) KCNJ11
KCNJ11 {u} (Gene) is bound by {v} (Compound) Minoxidil
Minoxidil {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Molindone
Diazoxide {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is regulated by {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Molindone
Diazoxide {u} (Compound) downregulates {v} (Gene) CYCS
CYCS {u} (Gene) regulates {v} (Gene) UGDH
UGDH {u} (Gene) is downregulated by {v} (Compound) Molindone
Diazoxide {u} (Compound) binds {v} (Gene) CA2
CA2 {u} (Gene) regulates {v} (Gene) CRYZ
CRYZ {u} (Gene) is downregulated by {v} (Compound) Molindone
Diazoxide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Molindone (Compound)
Diazoxide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Molindone (Compound)
Diazoxide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is regulated by TSKU (Gene) and TSKU (Gene) is upregulated by Molindone (Compound)
Diazoxide (Compound) downregulates CYCS (Gene) and CYCS (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Molindone (Compound)
Diazoxide (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Scopolamine (Compound) and Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Diazoxide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide (Compound) causes Muscle spasms (Side Effect) and Muscle spasms (Side Effect) is caused by Molindone (Compound)
Diazoxide (Compound) binds KCNJ11 (Gene) and KCNJ11 (Gene) is bound by Minoxidil (Compound) and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Molindone
Diazoxide (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is regulated by UGDH (Gene) and UGDH (Gene) is downregulated by Molindone (Compound)
Diazoxide (Compound) downregulates CYCS (Gene) and CYCS (Gene) regulates UGDH (Gene) and UGDH (Gene) is downregulated by Molindone (Compound)
Diazoxide (Compound) binds CA2 (Gene) and CA2 (Gene) regulates CRYZ (Gene) and CRYZ (Gene) is downregulated by Molindone (Compound)