DDInter1340 DDInter1291
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class, and its approval was followed by the formulation of many other proton pump inhibitor drugs. Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer durations of action. The most popular of the third generation dihydropyridines is [amlodipine]. Nifedipine was granted FDA approval on 31 December 1981.
Omeprazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Nifedipine
Omeprazole {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is palliated by {v} (Compound) Nifedipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Sleep disorder
Sleep disorder {u} (Side Effect) is caused by {v} (Compound) Nifedipine
Omeprazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Amlodipine
Amlodipine {u} (Compound) resembles {v} (Compound) Nifedipine
Omeprazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nifedipine
Omeprazole {u} (Compound) binds {v} (Gene) ABCC3
ABCC3 {u} (Gene) regulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Nifedipine
Omeprazole {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) downregulates {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nifedipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Sleep disorder
Sleep disorder {u} (Side Effect) is caused by {v} (Compound) Lercanidipine
Lercanidipine {u} (Compound) resembles {v} (Compound) Nifedipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Abnormal vision
Abnormal vision {u} (Side Effect) is caused by {v} (Compound) Nicardipine
Nicardipine {u} (Compound) resembles {v} (Compound) Nifedipine
Omeprazole {u} (Compound) causes {v} (Side Effect) Haemolytic anaemia
Haemolytic anaemia {u} (Side Effect) is caused by {v} (Compound) Repaglinide
Repaglinide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nifedipine
Omeprazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Nifedipine (Compound)
Omeprazole (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Nifedipine (Compound)
Omeprazole (Compound) causes Sleep disorder (Side Effect) and Sleep disorder (Side Effect) is caused by Nifedipine (Compound)
Omeprazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amlodipine (Compound) and Amlodipine (Compound) resembles Nifedipine (Compound)
Omeprazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nicardipine (Compound) and Nicardipine (Compound) resembles Nifedipine (Compound)
Omeprazole (Compound) binds ABCC3 (Gene) and ABCC3 (Gene) regulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Nifedipine (Compound)
Omeprazole (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) downregulates ABCB1 (Gene) and ABCB1 (Gene) is bound by Nifedipine (Compound)
Omeprazole (Compound) causes Sleep disorder (Side Effect) and Sleep disorder (Side Effect) is caused by Lercanidipine (Compound) and Lercanidipine (Compound) resembles Nifedipine (Compound)
Omeprazole (Compound) causes Abnormal vision (Side Effect) and Abnormal vision (Side Effect) is caused by Nicardipine (Compound) and Nicardipine (Compound) resembles Nifedipine (Compound)
Omeprazole (Compound) causes Haemolytic anaemia (Side Effect) and Haemolytic anaemia (Side Effect) is caused by Repaglinide (Compound) and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine