DDInter1795 DDInter1376
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Thiopental {u} (Compound) resembles {v} (Compound) Amobarbital
Thiopental {u} (Compound) binds {v} (Gene) GABRA6
Thiopental {u} may cause a minor interaction that can limit clinical effects when taken with {v} Cimetidine
Thiopental {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sulfasalazine
Thiopental {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Thiopental {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Iodide I-131
Thiopental {u} may lead to a major life threatening interaction when taken with {v} Warfarin
Thiopental (Compound) resembles Amobarbital (Compound)
Thiopental (Compound) binds GABRA6 (Gene)
Thiopental may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Thiopental may cause a minor interaction that can limit clinical effects when taken with Sulfasalazine
Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Thiopental may lead to a major life threatening interaction when taken with Warfarin