DDInter343 DDInter1397
Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allergic rhinitis_. The prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals. Furthermore, some antihistamine agents that are used to treat this condition cause undesirable, sedating effects. Cetirizine is one of the first second-generation H1 antihistamines (SGAHs) formulated to selectively inhibit the H1 receptor
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Cetirizine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) causes {v} (Side Effect) Muscular weakness
Muscular weakness {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) resembles {v} (Compound) Ifenprodil
Ifenprodil {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) regulates {v} (Gene) DHCR24
DHCR24 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) resembles {v} (Compound) Bepotastine
Bepotastine {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) downregulates {v} (Gene) CCNB2
CCNB2 {u} (Gene) is regulated by {v} (Gene) SCNN1A
SCNN1A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cyclizine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Cetirizine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyclizine
Cyclizine {u} (Compound) upregulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Cetirizine {u} (Compound) resembles {v} (Compound) Flunarizine
Flunarizine {u} (Compound) binds {v} (Gene) CYP2B6
CYP2B6 {u} (Gene) is bound by {v} (Compound) Paroxetine
Cetirizine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Paroxetine (Compound)
Cetirizine (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by Paroxetine (Compound)
Cetirizine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) interacts with CDKN1A (Gene) and CCNB2 (Gene) is regulated by CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Paroxetine (Compound)
Cetirizine (Compound) resembles Ifenprodil (Compound) and Ifenprodil (Compound) binds EBP (Gene) and EBP (Gene) is upregulated by Paroxetine (Compound)
Cetirizine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) regulates DHCR24 (Gene) and DHCR24 (Gene) is upregulated by Paroxetine (Compound)
Cetirizine (Compound) resembles Bepotastine (Compound) and Bepotastine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Paroxetine (Compound)
Cetirizine (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is regulated by SCNN1A (Gene) and SCNN1A (Gene) is upregulated by Paroxetine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Cetirizine (Compound) resembles Flunarizine (Compound) and Flunarizine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Paroxetine (Compound)