DDInter1764 DDInter856
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Tenecteplase {u} may cause a minor interaction that can limit clinical effects when taken with {v} Turmeric
Tenecteplase {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fluoxetine
Tenecteplase {u} may lead to a major life threatening interaction when taken with {v} Defibrotide
Tenecteplase {u} may lead to a major life threatening interaction when taken with {v} Lepirudin
Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine
Tenecteplase may lead to a major life threatening interaction when taken with Defibrotide
Tenecteplase may lead to a major life threatening interaction when taken with Lepirudin