DDInter458 DDInter1274
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) upregulates {v} (Gene) RPN1
RPN1 {u} (Gene) is downregulated by {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) causes {v} (Side Effect) Dysuria
Dysuria {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Aripiprazole
Aripiprazole {u} (Compound) resembles {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) downregulates {v} (Gene) ADI1
ADI1 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) downregulates {v} (Gene) SDHB
SDHB {u} (Gene) is regulated by {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) upregulates {v} (Gene) RPN1
RPN1 {u} (Gene) is downregulated by {v} (Compound) Quetiapine
Quetiapine {u} (Compound) resembles {v} (Compound) Nefazodone
Cyclosporine {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Trifluoperazine
Trifluoperazine {u} (Compound) resembles {v} (Compound) Nefazodone
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Cyclosporine (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Nefazodone (Compound)
Cyclosporine (Compound) upregulates RPN1 (Gene) and RPN1 (Gene) is downregulated by Nefazodone (Compound)
Cyclosporine (Compound) causes Dysuria (Side Effect) and Dysuria (Side Effect) is caused by Nefazodone (Compound)
Cyclosporine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aripiprazole (Compound) and Aripiprazole (Compound) resembles Nefazodone (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Nefazodone (Compound)
Cyclosporine (Compound) downregulates ADI1 (Gene) and ADI1 (Gene) is downregulated by Quetiapine (Compound) and Quetiapine (Compound) resembles Nefazodone (Compound)
Cyclosporine (Compound) downregulates SDHB (Gene) and SDHB (Gene) is regulated by ABCB1 (Gene) and ABCB1 (Gene) is bound by Nefazodone (Compound)
Cyclosporine (Compound) upregulates RPN1 (Gene) and RPN1 (Gene) is downregulated by Quetiapine (Compound) and Quetiapine (Compound) resembles Nefazodone (Compound)
Cyclosporine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Trifluoperazine (Compound) and Trifluoperazine (Compound) resembles Nefazodone (Compound)