DDInter1822 DDInter1277
Aminoglycosides, many of which are derived directly from _Streptomyces_ spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is notable for its use in treating chronic _Pseudomonas aeruginosa_ infections in cystic fibrosis patients, as _P. aeruginosa_ is notoriously inherently resistant to many antibiotics.[A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to treat a variety of infections caused by susceptible bacteria.[L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and ototoxicity, yet it remains a valuable option in the face of growing resistance to front-line antibiotics such as β-lactams and cephalosporins.[A232294, A232349, L
Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer of neomycin B, making these two stereoisomers the active components of neomycin.[A175042,A191529] Neomycin A, or [neamine], is a moiety that conjoins two molecules of neomycin B and C together. Neomycin is active against both gram-positive and gram-negative organisms and mediates its pharmacological action by binding to bacterial ribosomes and inhibiting protein synthesis, which is crucial for the survival of bacteria. Neomycin sulfate is the most common form for pharmaceutical preparations; because the compound is a complex, the amount of neomycin in products is measured in units. Neomycin sulfate as monotherapy is available in an oral solution for adjunct use in the treatment of hepatic coma. It is also used in combination with [polymyxin B] sulfates and [hydrocortisone] in otic suspensions for use in the treatment of bacterial infections in the external auditory canal, including infections caused by medical procedures in the ear. Neomycin is also used in combination with [polymyxin B] sulfates and [dexamethasone] in ophthalmic preparations for use in the treatment of inflammatory conditions and infections in the eye. Neomycin is also available in over-the-counter topical products to prevent minor skin infections.
Tobramycin {u} (Compound) resembles {v} (Compound) Neomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Neomycin
Tobramycin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Neomycin
Tobramycin {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Neomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Lactulose
Lactulose {u} may cause a minor interaction that can limit clinical effects when taken with {v} Neomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Gentamicin
Gentamicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Kanamycin
Kanamycin {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Acarbose
Acarbose {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Neomycin
Tobramycin {u} (Compound) resembles {v} (Compound) Paromomycin
Paromomycin {u} (Compound) resembles {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Neomycin
Tobramycin {u} (Compound) is included by {v} (Pharmacologic Class) Aminoglycosides
Aminoglycosides {u} (Pharmacologic Class) includes {v} (Compound) Amikacin
Amikacin {u} (Compound) resembles {v} (Compound) Neomycin
Tobramycin (Compound) resembles Neomycin (Compound)
Tobramycin (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Neomycin (Compound)
Tobramycin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Neomycin (Compound)
Tobramycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Tobramycin (Compound) resembles Lactulose (Compound) and Lactulose may cause a minor interaction that can limit clinical effects when taken with Neomycin
Tobramycin (Compound) resembles Gentamicin (Compound) and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Tobramycin (Compound) resembles Kanamycin (Compound) and Kanamycin (Compound) resembles Neomycin (Compound) and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Tobramycin (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Acarbose (Compound) and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Tobramycin (Compound) resembles Paromomycin (Compound) and Paromomycin (Compound) resembles Amikacin (Compound) and Amikacin (Compound) resembles Neomycin (Compound)
Tobramycin (Compound) is included by Aminoglycosides (Pharmacologic Class) and Aminoglycosides (Pharmacologic Class) includes Amikacin (Compound) and Amikacin (Compound) resembles Neomycin (Compound)