DDInter463 DDInter150
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Dacarbazine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) downregulates {v} (Gene) NUCB2
NUCB2 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) is regulated by {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is associated with {v} (Gene) GSTM1
GSTM1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) regulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) treats {v} (Disease) peripheral nervous system neoplasm
peripheral nervous system neoplasm {u} (Disease) is associated with {v} (Gene) SUZ12
SUZ12 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) treats {v} (Disease) pancreatic cancer
pancreatic cancer {u} (Disease) upregulates {v} (Gene) XDH
XDH {u} (Gene) is bound by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) binds {v} (Gene) POLA2
POLA2 {u} (Gene) regulates {v} (Gene) PSRC1
PSRC1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) upregulates {v} (Gene) RRS1
RRS1 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Dacarbazine {u} (Compound) upregulates {v} (Gene) PCK2
PCK2 {u} (Gene) regulates {v} (Gene) RPS4Y1
RPS4Y1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Dacarbazine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is upregulated by Azathioprine (Compound)
Dacarbazine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) downregulates NUCB2 (Gene) and NUCB2 (Gene) is upregulated by Azathioprine (Compound)
Dacarbazine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) is regulated by HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Dacarbazine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is associated with GSTM1 (Gene) and GSTM1 (Gene) is bound by Azathioprine (Compound)
Dacarbazine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) regulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Dacarbazine (Compound) treats peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is associated with SUZ12 (Gene) and SUZ12 (Gene) is downregulated by Azathioprine (Compound)
Dacarbazine (Compound) treats pancreatic cancer (Disease) and pancreatic cancer (Disease) upregulates XDH (Gene) and XDH (Gene) is bound by Azathioprine (Compound)
Dacarbazine (Compound) binds POLA2 (Gene) and POLA2 (Gene) regulates PSRC1 (Gene) and PSRC1 (Gene) is downregulated by Azathioprine (Compound)
Dacarbazine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) upregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Azathioprine (Compound)
Dacarbazine (Compound) upregulates PCK2 (Gene) and PCK2 (Gene) regulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Azathioprine (Compound)