DDInter759 DDInter1840
An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women.
Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S. Food and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. On October 23, 2015, the FDA approved trabectedin, (as Yondelis), for the treatment of specific soft tissue sarcomas.
Fluoxymesterone {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) resembles {v} (Compound) Potassium Canrenoate
Potassium Canrenoate {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trabectedin
Fluoxymesterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) resembles {v} (Compound) Spironolactone
Spironolactone {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Fluoxymesterone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Triamcinolone
Triamcinolone {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) treats {v} (Disease) breast cancer
breast cancer {u} (Disease) is associated with {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) binds {v} (Gene) AR
AR {u} (Gene) interacts with {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Fluoxymesterone {u} (Compound) binds {v} (Gene) ESR1
ESR1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) regulates {v} (Gene) SRC
SRC {u} (Gene) is bound by {v} (Compound) Trabectedin
Fluoxymesterone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Trabectedin (Compound)
Fluoxymesterone (Compound) resembles Potassium Canrenoate (Compound) and Potassium Canrenoate (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Trabectedin (Compound)
Fluoxymesterone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trabectedin (Compound)
Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Trabectedin (Compound)
Fluoxymesterone (Compound) resembles Spironolactone (Compound) and Spironolactone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Trabectedin (Compound)
Fluoxymesterone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Trabectedin (Compound)
Fluoxymesterone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Trabectedin (Compound)
Fluoxymesterone (Compound) treats breast cancer (Disease) and breast cancer (Disease) is associated with CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trabectedin (Compound)
Fluoxymesterone (Compound) binds AR (Gene) and AR (Gene) interacts with SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)
Fluoxymesterone (Compound) binds ESR1 (Gene) and ESR1 (Gene) interacts with SRC (Gene) and ESR1 (Gene) regulates SRC (Gene) and SRC (Gene) is bound by Trabectedin (Compound)