DDInter350 DDInter405
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been investigated.
Chlorambucil {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) upregulates {v} (Gene) FAS
FAS {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) downregulates {v} (Gene) DLGAP5
DLGAP5 {u} (Gene) is downregulated by {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) resembles {v} (Compound) Melphalan
Melphalan {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofarabine
Chlorambucil {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Nelarabine
Nelarabine {u} (Compound) resembles {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) upregulates {v} (Gene) FAS
FAS {u} (Gene) is upregulated by {v} (Compound) Cladribine
Cladribine {u} may lead to a major life threatening interaction when taken with {v} Clofarabine
Chlorambucil {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) upregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Clofarabine
Chlorambucil {u} (Compound) upregulates {v} (Gene) BLCAP
BLCAP {u} (Gene) is regulated by {v} (Gene) PHKG2
PHKG2 {u} (Gene) is upregulated by {v} (Compound) Clofarabine
Chlorambucil (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Clofarabine (Compound)
Chlorambucil (Compound) upregulates FAS (Gene) and FAS (Gene) is upregulated by Clofarabine (Compound)
Chlorambucil (Compound) downregulates DLGAP5 (Gene) and DLGAP5 (Gene) is downregulated by Clofarabine (Compound)
Chlorambucil (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Clofarabine (Compound)
Chlorambucil (Compound) resembles Melphalan (Compound) and Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine
Chlorambucil (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nelarabine (Compound) and Nelarabine (Compound) resembles Clofarabine (Compound)
Chlorambucil (Compound) upregulates FAS (Gene) and FAS (Gene) is upregulated by Cladribine (Compound) and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Chlorambucil (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Clofarabine (Compound)
Chlorambucil (Compound) upregulates DDB2 (Gene) and DDB2 (Gene) is downregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Clofarabine (Compound)
Chlorambucil (Compound) upregulates BLCAP (Gene) and BLCAP (Gene) is regulated by PHKG2 (Gene) and PHKG2 (Gene) is upregulated by Clofarabine (Compound)