DDInter1209 DDInter899
Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of fungal CYP450 14α-lanosterol demethylase activity.[A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.[A214523, L14021] It is currently available as a variety of prescription and over the counter products. Despite having been in clinical use for an extended period, resistance to m
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in November 2013 for the treatment of mantle cell lymphoma (MCL) under accelerated approval; however, in April 2023, the drug manufacturer withdrew the accelerated approvals for ibrutinib in the US. Ibrutinib was approved by the EMA in October 2014 and by Health Canada in November 2014. It is currently approved for the treatment of various conditions, such as chronic lymphocytic leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017. Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017.
Miconazole {u} (Compound) resembles {v} (Compound) Tioconazole
Miconazole {u} (Compound) resembles {v} (Compound) Triclosan
Miconazole {u} (Compound) binds {v} (Gene) KCNMB1
Miconazole {u} (Compound) upregulates {v} (Gene) KIT
Miconazole {u} (Compound) is included by {v} (Pharmacologic Class) Azoles
Miconazole {u} (Compound) downregulates {v} (Gene) STUB1
Miconazole {u} (Compound) causes {v} (Side Effect) Mediastinal disorder
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Escitalopram
Miconazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Modafinil
Miconazole {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Tofacitinib
Miconazole (Compound) resembles Tioconazole (Compound)
Miconazole (Compound) resembles Triclosan (Compound)
Miconazole (Compound) binds KCNMB1 (Gene)
Miconazole (Compound) upregulates KIT (Gene)
Miconazole (Compound) is included by Azoles (Pharmacologic Class)
Miconazole (Compound) downregulates STUB1 (Gene)
Miconazole (Compound) causes Mediastinal disorder (Side Effect)
Miconazole may cause a minor interaction that can limit clinical effects when taken with Escitalopram
Miconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib