DDInter1662 DDInter1197
Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Sertraline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Metoclopramide
Sertraline {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Metoclopramide
Sertraline {u} (Compound) resembles {v} (Compound) Maprotiline
Maprotiline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Sertraline {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cisapride
Cisapride {u} (Compound) resembles {v} (Compound) Metoclopramide
Sertraline {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Sertraline {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Sexual dysfunction {u} (Side Effect) is caused by {v} (Compound) Clonidine
Clonidine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Sertraline {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Sunitinib
Sunitinib {u} (Compound) resembles {v} (Compound) Metoclopramide
Sertraline {u} (Compound) causes {v} (Side Effect) Bronchospasm
Bronchospasm {u} (Side Effect) is caused by {v} (Compound) Acetaminophen
Acetaminophen {u} may cause a minor interaction that can limit clinical effects when taken with {v} Metoclopramide
Sertraline {u} (Compound) causes {v} (Side Effect) Extrapyramidal disorder
Extrapyramidal disorder {u} (Side Effect) is caused by {v} (Compound) Desvenlafaxine
Desvenlafaxine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Metoclopramide
Sertraline {u} (Compound) binds {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Procaine
Procaine {u} (Compound) resembles {v} (Compound) Metoclopramide
Sertraline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Metoclopramide (Compound)
Sertraline (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Sertraline (Compound) resembles Maprotiline (Compound) and Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Sertraline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cisapride (Compound) and Cisapride (Compound) resembles Metoclopramide (Compound)
Sertraline (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)
Sertraline (Compound) causes Sexual dysfunction (Side Effect) and Sexual dysfunction (Side Effect) is caused by Clonidine (Compound) and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Sertraline (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Sunitinib (Compound) and Sunitinib (Compound) resembles Metoclopramide (Compound)
Sertraline (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Acetaminophen (Compound) and Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Sertraline (Compound) causes Extrapyramidal disorder (Side Effect) and Extrapyramidal disorder (Side Effect) is caused by Desvenlafaxine (Compound) and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide
Sertraline (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Procaine (Compound) and Procaine (Compound) resembles Metoclopramide (Compound)