DDInter363 DDInter535
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Chlorpromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) LPAR2
LPAR2 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) downregulates {v} (Gene) IARS2
IARS2 {u} (Gene) is regulated by {v} (Gene) GLUL
GLUL {u} (Gene) is bound by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) regulates {v} (Gene) PRKCQ
PRKCQ {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) downregulates {v} (Gene) ITGB1BP1
ITGB1BP1 {u} (Gene) regulates {v} (Gene) KIAA0753
KIAA0753 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) downregulates {v} (Gene) GTPBP8
GTPBP8 {u} (Gene) is regulated by {v} (Gene) HPRT1
HPRT1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Chlorpromazine {u} (Compound) upregulates {v} (Gene) MTHFD2
MTHFD2 {u} (Gene) is regulated by {v} (Gene) RBM6
RBM6 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Chlorpromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is downregulated by Diazoxide (Compound)
Chlorpromazine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Diazoxide (Compound)
Chlorpromazine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Chlorpromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by LPAR2 (Gene) and LPAR2 (Gene) is upregulated by Diazoxide (Compound)
Chlorpromazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is regulated by GLUL (Gene) and GLUL (Gene) is bound by Diazoxide (Compound)
Chlorpromazine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) regulates PRKCQ (Gene) and PRKCQ (Gene) is upregulated by Diazoxide (Compound)
Chlorpromazine (Compound) downregulates ITGB1BP1 (Gene) and ITGB1BP1 (Gene) regulates KIAA0753 (Gene) and KIAA0753 (Gene) is upregulated by Diazoxide (Compound)
Chlorpromazine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Chlorpromazine (Compound) downregulates GTPBP8 (Gene) and GTPBP8 (Gene) is regulated by HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Diazoxide (Compound)
Chlorpromazine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is regulated by RBM6 (Gene) and RBM6 (Gene) is upregulated by Diazoxide (Compound)