DDInter716 DDInter278
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Felodipine {u} (Compound) resembles {v} (Compound) Amlodipine
Felodipine {u} (Compound) resembles {v} (Compound) Isradipine
Felodipine {u} (Compound) treats {v} (Disease) hypertension
Felodipine {u} (Compound) binds {v} (Gene) CACNA1S
Felodipine {u} (Compound) upregulates {v} (Gene) CGRRF1
Felodipine {u} (Compound) is included by {v} (Pharmacologic Class) Calcium Channel Antagonists
Felodipine {u} (Compound) downregulates {v} (Gene) GJA1
Felodipine {u} (Compound) causes {v} (Side Effect) Sexual dysfunction
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Theophylline
Felodipine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Ticagrelor
Felodipine (Compound) resembles Amlodipine (Compound)
Felodipine (Compound) resembles Isradipine (Compound)
Felodipine (Compound) treats hypertension (Disease)
Felodipine (Compound) binds CACNA1S (Gene)
Felodipine (Compound) upregulates CGRRF1 (Gene)
Felodipine (Compound) is included by Calcium Channel Antagonists (Pharmacologic Class)
Felodipine (Compound) downregulates GJA1 (Gene)
Felodipine (Compound) causes Sexual dysfunction (Side Effect)
Felodipine may cause a minor interaction that can limit clinical effects when taken with Theophylline
Felodipine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor