DDInter740 DDInter927
Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.
Inotuzumab ozogamicin is an antibody-drug conjugate using linker and cytotoxic drug technology similar to that developed for the ground-breaking treatment Mylotarg (), which was approved by the US FDA in 2000 for the treatment of acute myeloid leukaemia. Inotuzumab ozogamicin consists of a recombinant humanised IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide, which is a potent DNA-binding cytotoxic agent . Developed by Pfizer and UCB, inotuzumab ozogamicin was granted approval by EU in June 2017 followed by FDA on August 17th, 2017 for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). ALL is a rapidly progressing cancer of the bone marrow that is associated with high mortality rates and low therapeutic response from standard chemotherapies in relasping conditions. In a randomized trial, inotuzumab ozogamicin displayed higher percentages of patients undergoing longer periods of complete remission with no evidence of disease in comparison to patients receiving alternative chemotherapy .
Flecainide {u} (Compound) resembles {v} (Compound) Mefloquine
Flecainide {u} (Compound) binds {v} (Gene) CYP2D6
Flecainide {u} (Compound) upregulates {v} (Gene) MTHFD2
Flecainide {u} (Compound) downregulates {v} (Gene) RRM2
Flecainide {u} (Compound) causes {v} (Side Effect) Shock
Flecainide (Compound) resembles Mefloquine (Compound)
Flecainide (Compound) binds CYP2D6 (Gene)
Flecainide (Compound) upregulates MTHFD2 (Gene)
Flecainide (Compound) downregulates RRM2 (Gene)
Flecainide (Compound) causes Shock (Side Effect)