DDInter1729 DDInter1826
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac
A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Sulindac {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Tolazamide
Sulindac {u} (Compound) causes {v} (Side Effect) Headache
Headache {u} (Side Effect) is caused by {v} (Compound) Tolbutamide
Tolbutamide {u} (Compound) resembles {v} (Compound) Tolazamide
Sulindac {u} (Compound) binds {v} (Gene) SLC22A6
SLC22A6 {u} (Gene) is bound by {v} (Compound) Tolbutamide
Tolbutamide {u} (Compound) resembles {v} (Compound) Tolazamide
Sulindac {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is associated with {v} (Disease) type 2 diabetes mellitus
type 2 diabetes mellitus {u} (Disease) is treated by {v} (Compound) Tolazamide
Sulindac {u} (Compound) binds {v} (Gene) AKR1B1
AKR1B1 {u} (Gene) regulates {v} (Gene) GDF15
GDF15 {u} (Gene) is downregulated by {v} (Compound) Tolazamide
Sulindac {u} (Compound) binds {v} (Gene) PPARD
PPARD {u} (Gene) is regulated by {v} (Gene) PSMD2
PSMD2 {u} (Gene) is downregulated by {v} (Compound) Tolazamide
Sulindac {u} (Compound) binds {v} (Gene) MAPK3
MAPK3 {u} (Gene) interacts with {v} (Gene) IER3
IER3 {u} (Gene) is downregulated by {v} (Compound) Tolazamide
Sulindac (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Tolazamide (Compound)
Sulindac (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Tolbutamide (Compound) and Tolbutamide (Compound) resembles Tolazamide (Compound)
Sulindac (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Tolbutamide (Compound) and Tolbutamide (Compound) resembles Tolazamide (Compound)
Sulindac (Compound) binds ALB (Gene) and ALB (Gene) is associated with type 2 diabetes mellitus (Disease) and type 2 diabetes mellitus (Disease) is treated by Tolazamide (Compound)
Sulindac (Compound) binds AKR1B1 (Gene) and AKR1B1 (Gene) regulates GDF15 (Gene) and GDF15 (Gene) is downregulated by Tolazamide (Compound)
Sulindac (Compound) binds PPARD (Gene) and PPARD (Gene) is regulated by PSMD2 (Gene) and PSMD2 (Gene) is downregulated by Tolazamide (Compound)
Sulindac (Compound) binds MAPK3 (Gene) and MAPK3 (Gene) interacts with IER3 (Gene) and IER3 (Gene) is downregulated by Tolazamide (Compound)