DDInter735 DDInter350
Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_. Human G-CSF is a glycoprotein that regulates the production and release of neutrophils from the bone marrow. Filgrastim mimics the biological actions of G-CSF to increase the levels of neutrophils in the blood. It has a number of therapeutic uses, including the management and prevention of infections and febrile neutropenia in patients receiving myelosuppressive chemotherapy or radiation therapy. It is also used to manage severe chronic neutropenia and mobilize hematopoietic progenitor cells to the
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomustine
Lomustine {u} (Compound) treats {v} (Disease) hematologic cancer
hematologic cancer {u} (Disease) is treated by {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomustine
Lomustine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bexarotene
Bexarotene {u} (Compound) causes {v} (Side Effect) Hyperuricaemia
Hyperuricaemia {u} (Side Effect) is caused by {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lomustine
Lomustine {u} (Compound) is included by {v} (Pharmacologic Class) Alkylating Activity
Alkylating Activity {u} (Pharmacologic Class) includes {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Floxuridine
Floxuridine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Carmustine
Carmustine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bortezomib
Bortezomib {u} may cause a minor interaction that can limit clinical effects when taken with {v} Melphalan
Melphalan {u} (Compound) resembles {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Bortezomib
Bortezomib {u} (Compound) downregulates {v} (Gene) DDB2
DDB2 {u} (Gene) is upregulated by {v} (Compound) Chlorambucil
Filgrastim {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Floxuridine
Floxuridine {u} (Compound) downregulates {v} (Gene) CENPA
CENPA {u} (Gene) is downregulated by {v} (Compound) Chlorambucil
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene (Compound) causes Hyperuricaemia (Side Effect) and Hyperuricaemia (Side Effect) is caused by Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine (Compound) is included by Alkylating Activity (Pharmacologic Class) and Alkylating Activity (Pharmacologic Class) includes Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan (Compound) resembles Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan (Compound) resembles Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib (Compound) downregulates DDB2 (Gene) and DDB2 (Gene) is upregulated by Chlorambucil (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine (Compound) downregulates CENPA (Gene) and CENPA (Gene) is downregulated by Chlorambucil (Compound)