DDInter115 DDInter856
Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
Ardeparin {u} (Compound) binds {v} (Gene) SERPIND1
Ardeparin {u} (Compound) causes {v} (Side Effect) Malaise
Ardeparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Pegaspargase
Ardeparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Niraparib
Ardeparin {u} may lead to a major life threatening interaction when taken with {v} Defibrotide
Ardeparin {u} may lead to a major life threatening interaction when taken with {v} Eptifibatide
Ardeparin {u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v} Fondaparinux
Ardeparin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v} Flurbiprofen
Ardeparin (Compound) binds SERPIND1 (Gene)
Ardeparin (Compound) causes Malaise (Side Effect)
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Ardeparin may lead to a major life threatening interaction when taken with Defibrotide
Ardeparin may lead to a major life threatening interaction when taken with Eptifibatide
Ardeparin (Compound) resembles Fondaparinux (Compound) and Ardeparin may lead to a major life threatening interaction when taken with Fondaparinux
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Ardeparin may lead to a major life threatening interaction when taken with Flurbiprofen