DDInter1834 DDInter1244
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Morphine
Topiramate {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Morphine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Morphine
Topiramate {u} (Compound) causes {v} (Side Effect) Thrombocytopenia
Thrombocytopenia {u} (Side Effect) is caused by {v} (Compound) Galantamine
Galantamine {u} (Compound) resembles {v} (Compound) Morphine
Topiramate {u} (Compound) causes {v} (Side Effect) Hypoaesthesia
Hypoaesthesia {u} (Side Effect) is caused by {v} (Compound) Hydromorphone
Hydromorphone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Topiramate {u} (Compound) causes {v} (Side Effect) Liver function test abnormal
Liver function test abnormal {u} (Side Effect) is caused by {v} (Compound) Methohexital
Methohexital {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Topiramate {u} (Compound) causes {v} (Side Effect) Pallor
Pallor {u} (Side Effect) is caused by {v} (Compound) Ephedrine
Ephedrine {u} may cause a minor interaction that can limit clinical effects when taken with {v} Morphine
Topiramate {u} (Compound) causes {v} (Side Effect) Ejaculation disorder
Ejaculation disorder {u} (Side Effect) is caused by {v} (Compound) Citalopram
Citalopram {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Topiramate {u} (Compound) treats {v} (Disease) obesity
obesity {u} (Disease) is treated by {v} (Compound) Sibutramine
Sibutramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Morphine
Topiramate {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Hydromorphone
Hydromorphone {u} may lead to a major life threatening interaction when taken with {v} Morphine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Morphine (Compound)
Topiramate (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Morphine (Compound)
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Galantamine (Compound) and Galantamine (Compound) resembles Morphine (Compound)
Topiramate (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Galantamine (Compound) and Galantamine (Compound) resembles Morphine (Compound)
Topiramate (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Hydromorphone (Compound) and Hydromorphone may lead to a major life threatening interaction when taken with Morphine
Topiramate (Compound) causes Liver function test abnormal (Side Effect) and Liver function test abnormal (Side Effect) is caused by Methohexital (Compound) and Methohexital may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Topiramate (Compound) causes Pallor (Side Effect) and Pallor (Side Effect) is caused by Ephedrine (Compound) and Ephedrine may cause a minor interaction that can limit clinical effects when taken with Morphine
Topiramate (Compound) causes Ejaculation disorder (Side Effect) and Ejaculation disorder (Side Effect) is caused by Citalopram (Compound) and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Topiramate (Compound) treats obesity (Disease) and obesity (Disease) is treated by Sibutramine (Compound) and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Morphine
Topiramate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Hydromorphone (Compound) and Hydromorphone may lead to a major life threatening interaction when taken with Morphine