DDInter416 DDInter76
This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot.
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Clotrimazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) binds {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) causes {v} (Side Effect) Aspartate aminotransferase increased
Aspartate aminotransferase increased {u} (Side Effect) is caused by {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) resembles {v} (Compound) Loperamide
Loperamide {u} may lead to a major life threatening interaction when taken with {v} Amiodarone
Clotrimazole {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Bortezomib
Bortezomib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Amiodarone
Clotrimazole {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Dronedarone
Dronedarone {u} (Compound) resembles {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) upregulates {v} (Gene) PHGDH
PHGDH {u} (Gene) regulates {v} (Gene) SQRDL
SQRDL {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) upregulates {v} (Gene) DDIT4
DDIT4 {u} (Gene) is regulated by {v} (Gene) ALDOC
ALDOC {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Clotrimazole {u} (Compound) binds {v} (Gene) CYP51A1
CYP51A1 {u} (Gene) regulates {v} (Gene) VAT1
VAT1 {u} (Gene) is upregulated by {v} (Compound) Amiodarone
Clotrimazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is upregulated by Amiodarone (Compound)
Clotrimazole (Compound) binds CYP51A1 (Gene) and CYP51A1 (Gene) is upregulated by Amiodarone (Compound)
Clotrimazole (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Amiodarone (Compound)
Clotrimazole (Compound) resembles Loperamide (Compound) and Loperamide may lead to a major life threatening interaction when taken with Amiodarone
Clotrimazole (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Bortezomib (Compound) and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone
Clotrimazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dronedarone (Compound) and Dronedarone (Compound) resembles Amiodarone (Compound)
Clotrimazole (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) regulates SQRDL (Gene) and SQRDL (Gene) is upregulated by Amiodarone (Compound)
Clotrimazole (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is regulated by ALDOC (Gene) and ALDOC (Gene) is upregulated by Amiodarone (Compound)
Clotrimazole (Compound) binds CYP51A1 (Gene) and CYP51A1 (Gene) regulates VAT1 (Gene) and VAT1 (Gene) is upregulated by Amiodarone (Compound)