DDInter569 DDInter1376
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties [L5269, F3352]. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system [L5263, L5266, L5269, F3379, A174541]. While its use in allergy therapy can sometimes fall out of favor due to its sedative effect, diphenhydramine has been repurposed
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clofedanol
Diphenhydramine {u} (Compound) resembles {v} (Compound) Toremifene
Diphenhydramine {u} (Compound) resembles {v} (Compound) Tropicamide
Diphenhydramine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dexbrompheniramine
Diphenhydramine {u} may lead to a major life threatening interaction when taken with {v} Tamoxifen
Diphenhydramine {u} (Compound) treats {v} (Disease) atopic dermatitis
Diphenhydramine {u} (Compound) binds {v} (Gene) CYP2B6
Diphenhydramine {u} (Compound) palliates {v} (Disease) schizophrenia
Diphenhydramine {u} (Compound) is included by {v} (Pharmacologic Class) Histamine H1 Receptor Antagonists
Diphenhydramine {u} (Compound) causes {v} (Side Effect) Dizziness
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Diphenhydramine (Compound) resembles Toremifene (Compound)
Diphenhydramine (Compound) resembles Tropicamide (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Diphenhydramine may lead to a major life threatening interaction when taken with Tamoxifen
Diphenhydramine (Compound) treats atopic dermatitis (Disease)
Diphenhydramine (Compound) binds CYP2B6 (Gene)
Diphenhydramine (Compound) palliates schizophrenia (Disease)
Diphenhydramine (Compound) is included by Histamine H1 Receptor Antagonists (Pharmacologic Class)
Diphenhydramine (Compound) causes Dizziness (Side Effect)