DDInter1866 DDInter535
A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release. Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance. When administered intravenously, diazoxide can be used to treat hypertensive emergencies; however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.[A255647,L44612]
Trifluoperazine {u} (Compound) downregulates {v} (Gene) NOSIP
NOSIP {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Trifluoperazine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Trifluoperazine {u} (Compound) downregulates {v} (Gene) NOSIP
NOSIP {u} (Gene) regulates {v} (Gene) KRT19
KRT19 {u} (Gene) is upregulated by {v} (Compound) Diazoxide
Trifluoperazine {u} (Compound) downregulates {v} (Gene) CAST
CAST {u} (Gene) regulates {v} (Gene) USP22
USP22 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Trifluoperazine {u} (Compound) downregulates {v} (Gene) NUP93
NUP93 {u} (Gene) is regulated by {v} (Gene) LAP3
LAP3 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Trifluoperazine {u} (Compound) causes {v} (Side Effect) Anorexia
Anorexia {u} (Side Effect) is caused by {v} (Compound) Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Propantheline
Propantheline {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Diazoxide
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Mepenzolate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Chlorothiazide
Chlorothiazide {u} (Compound) resembles {v} (Compound) Diazoxide
Trifluoperazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Mepenzolate
Mepenzolate {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Diazoxide
Trifluoperazine (Compound) downregulates NOSIP (Gene) and NOSIP (Gene) is downregulated by Diazoxide (Compound)
Trifluoperazine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Diazoxide (Compound)
Trifluoperazine (Compound) downregulates NOSIP (Gene) and NOSIP (Gene) regulates KRT19 (Gene) and KRT19 (Gene) is upregulated by Diazoxide (Compound)
Trifluoperazine (Compound) downregulates CAST (Gene) and CAST (Gene) regulates USP22 (Gene) and USP22 (Gene) is downregulated by Diazoxide (Compound)
Trifluoperazine (Compound) downregulates NUP93 (Gene) and NUP93 (Gene) is regulated by LAP3 (Gene) and LAP3 (Gene) is downregulated by Diazoxide (Compound)
Trifluoperazine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Chlorothiazide (Compound) and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Diazoxide (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Diazoxide (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Diazoxide (Compound)