DDInter641 DDInter652
Enflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market.[L13646,L13649] Unlike its other inhalational anesthetic counterparts including [isoflurane] and [halothane], enflurane is known to induce seizure activity. In addition, it is known to cause increased cardio depressant effects when compared to other inhaled anesthetics.
Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new products/biosimilars and dosage routes have been approved under various names over the last several decades , , . On August 16, 2018, Teva Pharmaceuticals USA gained approval to market its generic epinephrine auto-injector in 0.3 mg and 0.15 mg strengths . Dosage delivery routes for epinephrine include intravenous, inhalation, nebulization, intramuscular injection, and subcutaneous injection. In general, the most common uses of parenteral epinephrine are to relieve respiratory distress due to bronchospasm, to provide rapid relief of hypersensitivity (anaphylactic or anaphylactoid) reactions to drugs, animal serums and other allergens, and to prolong the action of infiltration anesthetics . In addition to the above functions, epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest , . It can be used in severe cases of croup .
Enflurane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Epinephrine
Enflurane {u} (Compound) resembles {v} (Compound) Isoflurane
Isoflurane {u} may lead to a major life threatening interaction when taken with {v} Epinephrine
Enflurane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Phenylephrine
Phenylephrine {u} (Compound) resembles {v} (Compound) Epinephrine
Enflurane {u} (Compound) resembles {v} (Compound) Desflurane
Desflurane {u} (Compound) resembles {v} (Compound) Isoflurane
Isoflurane {u} may lead to a major life threatening interaction when taken with {v} Epinephrine
Enflurane {u} (Compound) resembles {v} (Compound) Isoflurane
Isoflurane {u} (Compound) causes {v} (Side Effect) Ventricular arrhythmia
Ventricular arrhythmia {u} (Side Effect) is caused by {v} (Compound) Epinephrine
Enflurane {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Droxidopa
Droxidopa {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Epinephrine
Enflurane {u} (Compound) binds {v} (Gene) KCNN4
KCNN4 {u} (Gene) is bound by {v} (Compound) Halothane
Halothane {u} may lead to a major life threatening interaction when taken with {v} Epinephrine
Enflurane {u} (Compound) binds {v} (Gene) KCNN4
KCNN4 {u} (Gene) regulates {v} (Gene) ADRB2
ADRB2 {u} (Gene) is bound by {v} (Compound) Epinephrine
Enflurane {u} (Compound) binds {v} (Gene) KCNA1
KCNA1 {u} (Gene) is bound by {v} (Compound) Amitriptyline
Amitriptyline {u} may lead to a major life threatening interaction when taken with {v} Epinephrine
Enflurane {u} (Compound) binds {v} (Gene) ATP5D
ATP5D {u} (Gene) regulates {v} (Gene) TF
TF {u} (Gene) is upregulated by {v} (Compound) Epinephrine
Enflurane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Epinephrine (Compound)
Enflurane (Compound) resembles Isoflurane (Compound) and Isoflurane may lead to a major life threatening interaction when taken with Epinephrine
Enflurane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Phenylephrine (Compound) and Phenylephrine (Compound) resembles Epinephrine (Compound)
Enflurane (Compound) resembles Desflurane (Compound) and Desflurane (Compound) resembles Isoflurane (Compound) and Isoflurane may lead to a major life threatening interaction when taken with Epinephrine
Enflurane (Compound) resembles Isoflurane (Compound) and Isoflurane (Compound) causes Ventricular arrhythmia (Side Effect) and Ventricular arrhythmia (Side Effect) is caused by Epinephrine (Compound)
Enflurane (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Droxidopa (Compound) and Droxidopa may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Enflurane (Compound) binds KCNN4 (Gene) and KCNN4 (Gene) is bound by Halothane (Compound) and Halothane may lead to a major life threatening interaction when taken with Epinephrine
Enflurane (Compound) binds KCNN4 (Gene) and KCNN4 (Gene) regulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Epinephrine (Compound)
Enflurane (Compound) binds KCNA1 (Gene) and KCNA1 (Gene) is bound by Amitriptyline (Compound) and Amitriptyline may lead to a major life threatening interaction when taken with Epinephrine
Enflurane (Compound) binds ATP5D (Gene) and ATP5D (Gene) regulates TF (Gene) and TF (Gene) is upregulated by Epinephrine (Compound)