DDInter1834 DDInter397
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults. Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.
Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Topiramate {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Diphenylpyraline
Diphenylpyraline {u} (Compound) resembles {v} (Compound) Clidinium
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is downregulated by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is regulated by {v} (Gene) CHRM1
CHRM1 {u} (Gene) is bound by {v} (Compound) Clidinium
Topiramate {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Mepenzolate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Fexofenadine
Fexofenadine {u} (Compound) resembles {v} (Compound) Clidinium
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Hydrochlorothiazide
Hydrochlorothiazide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clidinium
Topiramate {u} (Compound) causes {v} (Side Effect) Tension
Tension {u} (Side Effect) is caused by {v} (Compound) Fexofenadine
Fexofenadine {u} (Compound) resembles {v} (Compound) Clidinium
Topiramate {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Ipratropium
Ipratropium {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clidinium
Topiramate {u} (Compound) downregulates {v} (Gene) DLD
DLD {u} (Gene) is downregulated by {v} (Compound) Digoxin
Digoxin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Clidinium
Topiramate (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Diphenylpyraline (Compound) and Diphenylpyraline (Compound) resembles Clidinium (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is regulated by CHRM1 (Gene) and CHRM1 (Gene) is bound by Clidinium (Compound)
Topiramate (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Mepenzolate (Compound) and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Fexofenadine (Compound) and Fexofenadine (Compound) resembles Clidinium (Compound)
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Hydrochlorothiazide (Compound) and Hydrochlorothiazide may cause a minor interaction that can limit clinical effects when taken with Clidinium
Topiramate (Compound) causes Tension (Side Effect) and Tension (Side Effect) is caused by Fexofenadine (Compound) and Fexofenadine (Compound) resembles Clidinium (Compound)
Topiramate (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Ipratropium (Compound) and Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Topiramate (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Digoxin (Compound) and Digoxin may cause a minor interaction that can limit clinical effects when taken with Clidinium