DDInter576 DDInter298
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. Early clinical studies of carboplatin were performed in 1982. Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.
Disulfiram {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) binds {v} (Gene) ALDH2
ALDH2 {u} (Gene) is associated with {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) upregulates {v} (Gene) CDKN1A
CDKN1A {u} (Gene) is associated with {v} (Disease) esophageal cancer
esophageal cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) upregulates {v} (Gene) TNFAIP3
TNFAIP3 {u} (Gene) is downregulated by {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) upregulates {v} (Gene) CXCL2
CXCL2 {u} (Gene) is downregulated by {v} (Disease) and {u} (Disease) associated with {v} (Gene) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) upregulates {v} (Gene) DNAJB1
DNAJB1 {u} (Gene) interacts with {v} (Gene) SOD1
SOD1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is associated with {v} (Disease) ovarian cancer
ovarian cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) upregulates {v} (Gene) DNAJB1
DNAJB1 {u} (Gene) interacts with {v} (Gene) and {u} (Gene) is regulated by {v} (Gene) NQO1
NQO1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) upregulates {v} (Gene) MYC
MYC {u} (Gene) is regulated by {v} (Gene) GSTP1
GSTP1 {u} (Gene) is bound by {v} (Compound) Carboplatin
Disulfiram {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is associated with {v} (Disease) and {u} (Gene) is upregulated by {v} (Disease) breast cancer
breast cancer {u} (Disease) is treated by {v} (Compound) Carboplatin
Disulfiram (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Carboplatin (Compound)
Disulfiram (Compound) binds ALDH2 (Gene) and ALDH2 (Gene) is associated with esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Disulfiram (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is associated with esophageal cancer (Disease) and esophageal cancer (Disease) is treated by Carboplatin (Compound)
Disulfiram (Compound) upregulates TNFAIP3 (Gene) and TNFAIP3 (Gene) is downregulated by ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Carboplatin (Compound)
Disulfiram (Compound) upregulates CXCL2 (Gene) and CXCL2 (Gene) is downregulated by breast cancer (Disease) and CXCL2 (Disease) associated with breast cancer (Gene) and breast cancer (Disease) is treated by Carboplatin (Compound)
Disulfiram (Compound) upregulates DNAJB1 (Gene) and DNAJB1 (Gene) interacts with SOD1 (Gene) and SOD1 (Gene) is bound by Carboplatin (Compound)
Disulfiram (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is associated with ovarian cancer (Disease) and ovarian cancer (Disease) is treated by Carboplatin (Compound)
Disulfiram (Compound) upregulates DNAJB1 (Gene) and DNAJB1 (Gene) interacts with NQO1 (Gene) and DNAJB1 (Gene) is regulated by NQO1 (Gene) and NQO1 (Gene) is bound by Carboplatin (Compound)
Disulfiram (Compound) upregulates MYC (Gene) and MYC (Gene) is regulated by GSTP1 (Gene) and GSTP1 (Gene) is bound by Carboplatin (Compound)
Disulfiram (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is associated with breast cancer (Disease) and BIRC5 (Gene) is upregulated by breast cancer (Disease) and breast cancer (Disease) is treated by Carboplatin (Compound)