DDInter1693 DDInter1658
Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate anhydrous is an electrolyte replenisher and is used in isosmotic solutions so that administration does not disturb normal electrolyte balance and does not lead to absorption or excretion of water and ions.
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated with substantial toxicity. Selpercatinib (LOXO-292) and pralsetinib (BLU-667) represent the first generation of specific RET RTK inhibitors for the treatment of RET-driven cancers.[A202049, A202055, A202052, L13604] Although selpercatinib is currently still under investigation in clinical trial NCT04211337, it was granted accelerated FDA approval on May 8, 2020, for specific RET-driven cancer indications. It is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc. Selpercatinib is also approved by the European Commission.
Sodium sulfate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Digitoxin
Sodium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Oxamniquine
Sodium sulfate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Fostemsavir
Sodium sulfate {u} may lead to a major life threatening interaction when taken with {v} Dronedarone
Sodium sulfate may cause a minor interaction that can limit clinical effects when taken with Digitoxin
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine
Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir
Sodium sulfate may lead to a major life threatening interaction when taken with Dronedarone