DDInter1938 DDInter1835
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Vincristine {u} (Compound) treats {v} (Disease) peripheral nervous system neoplasm
peripheral nervous system neoplasm {u} (Disease) is treated by {v} (Compound) Topotecan
Vincristine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Topotecan
Vincristine {u} (Compound) downregulates {v} (Gene) SPR
SPR {u} (Gene) is upregulated by {v} (Compound) Topotecan
Vincristine {u} (Compound) upregulates {v} (Gene) PMAIP1
PMAIP1 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Vincristine {u} (Compound) binds {v} (Gene) ABCC10
ABCC10 {u} (Gene) is upregulated by {v} (Compound) Topotecan
Vincristine {u} (Compound) downregulates {v} (Gene) TMEM97
TMEM97 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Vincristine {u} (Compound) upregulates {v} (Gene) TP53BP2
TP53BP2 {u} (Gene) is downregulated by {v} (Compound) Topotecan
Vincristine {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Topotecan
Vincristine {u} (Compound) resembles {v} (Compound) Vinorelbine
Vinorelbine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Vincristine {u} (Compound) resembles {v} (Compound) Vinblastine
Vinblastine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Topotecan
Vincristine (Compound) treats peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is treated by Topotecan (Compound)
Vincristine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Topotecan (Compound)
Vincristine (Compound) downregulates SPR (Gene) and SPR (Gene) is upregulated by Topotecan (Compound)
Vincristine (Compound) upregulates PMAIP1 (Gene) and PMAIP1 (Gene) is upregulated by Topotecan (Compound)
Vincristine (Compound) binds ABCC10 (Gene) and ABCC10 (Gene) is upregulated by Topotecan (Compound)
Vincristine (Compound) downregulates TMEM97 (Gene) and TMEM97 (Gene) is downregulated by Topotecan (Compound)
Vincristine (Compound) upregulates TP53BP2 (Gene) and TP53BP2 (Gene) is downregulated by Topotecan (Compound)
Vincristine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Topotecan (Compound)
Vincristine (Compound) resembles Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Vincristine (Compound) resembles Vinblastine (Compound) and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Topotecan