DDInter1497 DDInter604
A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage forms and those products formulated for preparation of solution prior to ingestion.
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol]. Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD). Drospirenone has been the subject of widespread safety concern due to the possibility of an increased risk of venous thromboembolism associated with its use.[A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as drospirenone exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be considered when assessing potential risks of hormonal contraceptive use.
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Spironolactone
Spironolactone {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Spironolactone
Spironolactone {u} (Compound) resembles {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} (Compound) causes {v} (Side Effect) Haemorrhage
Haemorrhage {u} (Side Effect) is caused by {v} (Compound) Progesterone
Progesterone {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Flurandrenolide
Flurandrenolide {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Spironolactone
Spironolactone {u} (Compound) resembles {v} (Compound) Testosterone Propionate
Testosterone Propionate {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Spironolactone
Spironolactone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Hydrocortisone
Hydrocortisone {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Spironolactone
Spironolactone {u} (Compound) resembles {v} (Compound) Methyltestosterone
Methyltestosterone {u} (Compound) resembles {v} (Compound) Drospirenone
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Eplerenone
Eplerenone {u} (Compound) binds {v} (Gene) NR3C2
NR3C2 {u} (Gene) is bound by {v} (Compound) Drospirenone
Potassium chloride {u} may lead to a major life threatening interaction when taken with {v} Eplerenone
Eplerenone {u} (Compound) causes {v} (Side Effect) Myocardial infarction
Myocardial infarction {u} (Side Effect) is caused by {v} (Compound) Drospirenone
Potassium chloride may lead to a major life threatening interaction when taken with Spironolactone and Spironolactone (Compound) resembles Drospirenone (Compound)
Potassium chloride (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Drospirenone (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Spironolactone and Spironolactone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Potassium chloride (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Progesterone (Compound) and Progesterone (Compound) resembles Drospirenone (Compound)
Potassium chloride (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Flurandrenolide (Compound) and Flurandrenolide (Compound) resembles Drospirenone (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Spironolactone and Spironolactone (Compound) resembles Testosterone Propionate (Compound) and Testosterone Propionate (Compound) resembles Drospirenone (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Spironolactone and Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Drospirenone (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Spironolactone and Spironolactone (Compound) resembles Methyltestosterone (Compound) and Methyltestosterone (Compound) resembles Drospirenone (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Eplerenone and Eplerenone (Compound) binds NR3C2 (Gene) and NR3C2 (Gene) is bound by Drospirenone (Compound)
Potassium chloride may lead to a major life threatening interaction when taken with Eplerenone and Eplerenone (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Drospirenone (Compound)