DDInter826 DDInter808
Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guidelines by Diabetes Canada, sulfonylurea drugs are considered a second-line glucose-lowering therapy following metformin. Because sulfonylureas require functional pancreatic beta cells for their therapeutic effectiveness, sulfonylureas are more commonly used for early-stage type 2 diabetes when there is no progressed pancreatic failure. Compared to the first-generation sulfonylureas, such as [tolbutamide] and [chlorpropamide], second-generation sulfonylureas contain a more non-polar side chain in their chemical structure, which enhances their hypoglycemic potency. Compared to other members of the sulfonyl
Garlic allergenic extract is used in allergenic testing.
Glipizide {u} (Compound) resembles {v} (Compound) Glyburide
Glipizide {u} (Compound) resembles {v} (Compound) Chlorpropamide
Glipizide {u} (Compound) treats {v} (Disease) type 2 diabetes mellitus
Glipizide {u} (Compound) binds {v} (Gene) ABCC8
Glipizide {u} (Compound) upregulates {v} (Gene) INPP4B
Glipizide {u} (Compound) is included by {v} (Pharmacologic Class) Sulfonylurea Compounds
Glipizide {u} (Compound) downregulates {v} (Gene) CEBPB
Glipizide {u} (Compound) causes {v} (Side Effect) Retinal haemorrhage
Glipizide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methylcellulose
Glipizide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Methyldopa
Glipizide (Compound) resembles Glyburide (Compound)
Glipizide (Compound) resembles Chlorpropamide (Compound)
Glipizide (Compound) treats type 2 diabetes mellitus (Disease)
Glipizide (Compound) binds ABCC8 (Gene)
Glipizide (Compound) upregulates INPP4B (Gene)
Glipizide (Compound) is included by Sulfonylurea Compounds (Pharmacologic Class)
Glipizide (Compound) downregulates CEBPB (Gene)
Glipizide (Compound) causes Retinal haemorrhage (Side Effect)
Glipizide may cause a minor interaction that can limit clinical effects when taken with Methylcellulose
Glipizide may cause a minor interaction that can limit clinical effects when taken with Methyldopa