DDInter1541 DDInter624
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
Propylthiouracil {u} (Compound) causes {v} (Side Effect) Hepatitis
Hepatitis {u} (Side Effect) is caused by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) upregulates {v} (Gene) WRB
WRB {u} (Gene) is regulated by {v} (Gene) CCDC86
CCDC86 {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) upregulates {v} (Gene) GPATCH8
GPATCH8 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) upregulates {v} (Gene) WRB
WRB {u} (Gene) regulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) upregulates {v} (Gene) NFKB2
NFKB2 {u} (Gene) interacts with {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) downregulates {v} (Gene) EXOSC4
EXOSC4 {u} (Gene) regulates {v} (Gene) OXA1L
OXA1L {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) downregulates {v} (Gene) ZW10
ZW10 {u} (Gene) is regulated by {v} (Gene) POLR2I
POLR2I {u} (Gene) is downregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is upregulated by {v} (Disease) acquired immunodeficiency syndrome
acquired immunodeficiency syndrome {u} (Disease) is treated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) downregulates {v} (Gene) SMC1A
SMC1A {u} (Gene) regulates {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Propylthiouracil {u} (Compound) downregulates {v} (Gene) CDC20
CDC20 {u} (Gene) is regulated by {v} (Gene) IKBKB
IKBKB {u} (Gene) is upregulated by {v} (Compound) Efavirenz
Propylthiouracil (Compound) causes Hepatitis (Side Effect) and Hepatitis (Side Effect) is caused by Efavirenz (Compound)
Propylthiouracil (Compound) upregulates WRB (Gene) and WRB (Gene) is regulated by CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Efavirenz (Compound)
Propylthiouracil (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Propylthiouracil (Compound) upregulates WRB (Gene) and WRB (Gene) regulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Efavirenz (Compound)
Propylthiouracil (Compound) upregulates NFKB2 (Gene) and NFKB2 (Gene) interacts with IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Propylthiouracil (Compound) downregulates EXOSC4 (Gene) and EXOSC4 (Gene) regulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Efavirenz (Compound)
Propylthiouracil (Compound) downregulates ZW10 (Gene) and ZW10 (Gene) is regulated by POLR2I (Gene) and POLR2I (Gene) is downregulated by Efavirenz (Compound)
Propylthiouracil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is upregulated by acquired immunodeficiency syndrome (Disease) and acquired immunodeficiency syndrome (Disease) is treated by Efavirenz (Compound)
Propylthiouracil (Compound) downregulates SMC1A (Gene) and SMC1A (Gene) regulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)
Propylthiouracil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is regulated by IKBKB (Gene) and IKBKB (Gene) is upregulated by Efavirenz (Compound)