DDInter1744 DDInter1397
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole]. Tamoxifen was granted FDA approval on 30 December 1977.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class. The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742]
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) binds {v} (Gene) EBP
EBP {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) binds {v} (Gene) and {u} (Compound) upregulates {v} (Gene) DHCR7
DHCR7 {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) downregulates {v} (Gene) EXOSC4
EXOSC4 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) causes {v} (Side Effect) Erythema multiforme
Erythema multiforme {u} (Side Effect) is caused by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TRAPPC6A
TRAPPC6A {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is associated with {v} (Disease) endogenous depression
endogenous depression {u} (Disease) is palliated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) upregulates {v} (Gene) LIPA
LIPA {u} (Gene) regulates {v} (Gene) GRN
GRN {u} (Gene) is upregulated by {v} (Compound) Paroxetine
Tamoxifen {u} (Compound) upregulates {v} (Gene) FDPS
FDPS {u} (Gene) regulates {v} (Gene) TPI1
TPI1 {u} (Gene) is downregulated by {v} (Compound) Paroxetine
Tamoxifen (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Paroxetine (Compound)
Tamoxifen (Compound) upregulates LIPA (Gene) and LIPA (Gene) is upregulated by Paroxetine (Compound)
Tamoxifen (Compound) binds EBP (Gene) and EBP (Gene) is upregulated by Paroxetine (Compound)
Tamoxifen (Compound) binds DHCR7 (Gene) and Tamoxifen (Compound) upregulates DHCR7 (Gene) and DHCR7 (Gene) is upregulated by Paroxetine (Compound)
Tamoxifen (Compound) downregulates EXOSC4 (Gene) and EXOSC4 (Gene) is downregulated by Paroxetine (Compound)
Tamoxifen (Compound) causes Erythema multiforme (Side Effect) and Erythema multiforme (Side Effect) is caused by Paroxetine (Compound)
Tamoxifen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Paroxetine (Compound)
Tamoxifen (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is associated with endogenous depression (Disease) and endogenous depression (Disease) is palliated by Paroxetine (Compound)
Tamoxifen (Compound) upregulates LIPA (Gene) and LIPA (Gene) regulates GRN (Gene) and GRN (Gene) is upregulated by Paroxetine (Compound)
Tamoxifen (Compound) upregulates FDPS (Gene) and FDPS (Gene) regulates TPI1 (Gene) and TPI1 (Gene) is downregulated by Paroxetine (Compound)