DDInter1215 DDInter1055
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones such as [gatifloxacin] and [moxifloxacin], is a member of the third generation of fluoroquinolones, colloquially referred to as the "respiratory quinolones" due to improved activity against gram-positive bacteria commonly implicated in respiratory infections.[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.
Mifepristone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) causes {v} (Side Effect) Cramp muscle
Cramp muscle {u} (Side Effect) is caused by {v} (Compound) Ciprofloxacin
Ciprofloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) causes {v} (Side Effect) Metrorrhagia
Metrorrhagia {u} (Side Effect) is caused by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Sparfloxacin
Sparfloxacin {u} (Compound) resembles {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) interacts with {v} (Gene) PRKACA
PRKACA {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) regulates {v} (Gene) TOP2A
TOP2A {u} (Gene) is bound by {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) regulates {v} (Gene) ERAP2
ERAP2 {u} (Gene) is upregulated by {v} (Compound) Levofloxacin
Mifepristone {u} (Compound) binds {v} (Gene) NR3C1
NR3C1 {u} (Gene) regulates {v} (Gene) PTPN1
PTPN1 {u} (Gene) is downregulated by {v} (Compound) Levofloxacin
Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levofloxacin (Compound)
Mifepristone (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Levofloxacin (Compound)
Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Mifepristone (Compound) causes Cramp muscle (Side Effect) and Cramp muscle (Side Effect) is caused by Ciprofloxacin (Compound) and Ciprofloxacin (Compound) resembles Levofloxacin (Compound)
Mifepristone (Compound) causes Metrorrhagia (Side Effect) and Metrorrhagia (Side Effect) is caused by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sparfloxacin (Compound) and Sparfloxacin (Compound) resembles Levofloxacin (Compound)
Mifepristone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) interacts with PRKACA (Gene) and PRKACA (Gene) is downregulated by Levofloxacin (Compound)
Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) regulates TOP2A (Gene) and TOP2A (Gene) is bound by Levofloxacin (Compound)
Mifepristone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) regulates ERAP2 (Gene) and ERAP2 (Gene) is upregulated by Levofloxacin (Compound)
Mifepristone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) regulates PTPN1 (Gene) and PTPN1 (Gene) is downregulated by Levofloxacin (Compound)