DDInter157 DDInter1016
Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. It is structurally related to erythromycin. Azithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism. This differentiates azithromycin from other types of macrolides. In March 2020, a small
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose]. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis.[A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.
Azithromycin {u} (Compound) resembles {v} (Compound) Telithromycin
Azithromycin {u} (Compound) resembles {v} (Compound) Dirithromycin
Azithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clarithromycin
Azithromycin {u} (Compound) binds {v} (Gene) CYP3A4
Azithromycin {u} (Compound) upregulates {v} (Gene) CDH3
Azithromycin {u} (Compound) is included by {v} (Pharmacologic Class) Macrolides
Azithromycin {u} (Compound) downregulates {v} (Gene) TSTA3
Azithromycin {u} (Compound) causes {v} (Side Effect) Face oedema
Azithromycin {u} may cause a minor interaction that can limit clinical effects when taken with {v} Naloxegol
Azithromycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Asparaginase Escherichia coli
Azithromycin (Compound) resembles Telithromycin (Compound)
Azithromycin (Compound) resembles Dirithromycin (Compound)
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Azithromycin (Compound) binds CYP3A4 (Gene)
Azithromycin (Compound) upregulates CDH3 (Gene)
Azithromycin (Compound) is included by Macrolides (Pharmacologic Class)
Azithromycin (Compound) downregulates TSTA3 (Gene)
Azithromycin (Compound) causes Face oedema (Side Effect)
Azithromycin may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli