DDInter54 DDInter154
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms. Alprazolam's adverse effects are generally related to the sedation it can cause. Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death. Alprazolam was given FDA approval on October 16, 1981.
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.
Alprazolam {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Alprazolam {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Azelastine
Alprazolam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clemastine
Clemastine {u} (Compound) resembles {v} (Compound) Azelastine
Alprazolam {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Azelastine
Alprazolam {u} (Compound) upregulates {v} (Gene) SESN1
SESN1 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Alprazolam {u} (Compound) downregulates {v} (Gene) MAPK13
MAPK13 {u} (Gene) is upregulated by {v} (Compound) Azelastine
Alprazolam {u} (Compound) downregulates {v} (Gene) TMEM109
TMEM109 {u} (Gene) is downregulated by {v} (Compound) Azelastine
Alprazolam {u} (Compound) causes {v} (Side Effect) Feeling abnormal
Feeling abnormal {u} (Side Effect) is caused by {v} (Compound) Azelastine
Alprazolam {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Azelastine
Alprazolam {u} (Compound) resembles {v} (Compound) Prazepam
Prazepam {u} (Compound) resembles {v} (Compound) Loxapine
Loxapine {u} (Compound) resembles {v} (Compound) Azelastine
Alprazolam (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)
Alprazolam (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Azelastine (Compound)
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine (Compound) resembles Azelastine (Compound)
Alprazolam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Azelastine (Compound)
Alprazolam (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Azelastine (Compound)
Alprazolam (Compound) downregulates MAPK13 (Gene) and MAPK13 (Gene) is upregulated by Azelastine (Compound)
Alprazolam (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregulated by Azelastine (Compound)
Alprazolam (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Azelastine (Compound)
Alprazolam (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Azelastine (Compound)
Alprazolam (Compound) resembles Prazepam (Compound) and Prazepam (Compound) resembles Loxapine (Compound) and Loxapine (Compound) resembles Azelastine (Compound)