DDInter1197 DDInter1180
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures. One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.
Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective in decreasing the rate of recurrence of peptic ulcers as well as preventing complications.
Metoclopramide {u} (Compound) resembles {v} (Compound) Cinchocaine
Metoclopramide {u} (Compound) resembles {v} (Compound) Procaine
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Procainamide
Metoclopramide {u} (Compound) binds {v} (Gene) DRD3
Metoclopramide {u} (Compound) palliates {v} (Disease) migraine
Metoclopramide {u} (Compound) is included by {v} (Pharmacologic Class) Dopamine D2 Antagonists
Metoclopramide {u} (Compound) causes {v} (Side Effect) Somnolence
Metoclopramide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Dopamine
Metoclopramide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Desvenlafaxine
Metoclopramide {u} may lead to a major life threatening interaction when taken with {v} Paliperidone
Metoclopramide (Compound) resembles Cinchocaine (Compound)
Metoclopramide (Compound) resembles Procaine (Compound)
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Procainamide
Metoclopramide (Compound) binds DRD3 (Gene)
Metoclopramide (Compound) palliates migraine (Disease)
Metoclopramide (Compound) is included by Dopamine D2 Antagonists (Pharmacologic Class)
Metoclopramide (Compound) causes Somnolence (Side Effect)
Metoclopramide may cause a minor interaction that can limit clinical effects when taken with Dopamine
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine
Metoclopramide may lead to a major life threatening interaction when taken with Paliperidone