DDInter458 DDInter1759
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) binds {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) causes {v} (Side Effect) Rash
Rash {u} (Side Effect) is caused by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is associated with {v} (Disease) coronary artery disease
coronary artery disease {u} (Disease) is treated by {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) downregulates {v} (Gene) NUP85
NUP85 {u} (Gene) is downregulated by {v} (Compound) Candesartan
Candesartan {u} (Compound) resembles {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) downregulates {v} (Gene) NUP85
NUP85 {u} (Gene) is regulated by {v} (Gene) PPARG
PPARG {u} (Gene) is bound by {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) treats {v} (Disease) focal segmental glomerulosclerosis
focal segmental glomerulosclerosis {u} (Disease) resembles {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) downregulates {v} (Gene) BIRC5
BIRC5 {u} (Gene) is associated with {v} (Disease) hypertension
hypertension {u} (Disease) is treated by {v} (Compound) Telmisartan
Cyclosporine {u} (Compound) treats {v} (Disease) focal segmental glomerulosclerosis
focal segmental glomerulosclerosis {u} (Disease) is associated with {v} (Gene) AGTR1
AGTR1 {u} (Gene) is bound by {v} (Compound) Telmisartan
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Telmisartan (Compound)
Cyclosporine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telmisartan (Compound)
Cyclosporine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Cyclosporine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Cyclosporine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is associated with coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Telmisartan (Compound)
Cyclosporine (Compound) downregulates NUP85 (Gene) and NUP85 (Gene) is downregulated by Candesartan (Compound) and Candesartan (Compound) resembles Telmisartan (Compound)
Cyclosporine (Compound) downregulates NUP85 (Gene) and NUP85 (Gene) is regulated by PPARG (Gene) and PPARG (Gene) is bound by Telmisartan (Compound)
Cyclosporine (Compound) treats focal segmental glomerulosclerosis (Disease) and focal segmental glomerulosclerosis (Disease) resembles hypertension (Disease) and hypertension (Disease) is treated by Telmisartan (Compound)
Cyclosporine (Compound) downregulates BIRC5 (Gene) and BIRC5 (Gene) is associated with hypertension (Disease) and hypertension (Disease) is treated by Telmisartan (Compound)
Cyclosporine (Compound) treats focal segmental glomerulosclerosis (Disease) and focal segmental glomerulosclerosis (Disease) is associated with AGTR1 (Gene) and AGTR1 (Gene) is bound by Telmisartan (Compound)