DDInter459 DDInter1747
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
Cyproheptadine {u} (Compound) resembles {v} (Compound) Metixene
Cyproheptadine {u} (Compound) resembles {v} (Compound) Nortriptyline
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methdilazine
Cyproheptadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Protriptyline
Cyproheptadine {u} (Compound) treats {v} (Disease) allergic rhinitis
Cyproheptadine {u} (Compound) binds {v} (Gene) UGT1A3
Cyproheptadine {u} (Compound) upregulates {v} (Gene) KAT6A
Cyproheptadine {u} (Compound) palliates {v} (Disease) migraine
Cyproheptadine {u} (Compound) downregulates {v} (Gene) RPA1
Cyproheptadine {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Cyproheptadine (Compound) resembles Metixene (Compound)
Cyproheptadine (Compound) resembles Nortriptyline (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline
Cyproheptadine (Compound) treats allergic rhinitis (Disease)
Cyproheptadine (Compound) binds UGT1A3 (Gene)
Cyproheptadine (Compound) upregulates KAT6A (Gene)
Cyproheptadine (Compound) palliates migraine (Disease)
Cyproheptadine (Compound) downregulates RPA1 (Gene)
Cyproheptadine (Compound) causes Agranulocytosis (Side Effect)