DDInter90 DDInter576
Amprenavir is a protease inhibitor used to treat HIV infection.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Amprenavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Amprenavir {u} (Compound) causes {v} (Side Effect) Paraesthesia
Paraesthesia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Amprenavir {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) interacts with {v} (Gene) STUB1
STUB1 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Amprenavir {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) ERO1L
ERO1L {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Amprenavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Amprenavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clindamycin
Clindamycin {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Amprenavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Betamethasone
Betamethasone {u} (Compound) downregulates {v} (Gene) FHL2
FHL2 {u} (Gene) is upregulated by {v} (Compound) Disulfiram
Amprenavir {u} may lead to a major life threatening interaction when taken with {v} Methylprednisolone
Methylprednisolone {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Disulfiram
Amprenavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Clindamycin
Clindamycin {u} (Compound) causes {v} (Side Effect) Asthenia
Asthenia {u} (Side Effect) is caused by {v} (Compound) Disulfiram
Amprenavir {u} (Compound) binds {v} (Gene) CYP3A5
CYP3A5 {u} (Gene) regulates {v} (Gene) CDC20
CDC20 {u} (Gene) is downregulated by {v} (Compound) Disulfiram
Amprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Amprenavir (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Disulfiram (Compound)
Amprenavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) interacts with STUB1 (Gene) and STUB1 (Gene) is downregulated by Disulfiram (Compound)
Amprenavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates ERO1L (Gene) and ERO1L (Gene) is upregulated by Disulfiram (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Clindamycin and Clindamycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) downregulates FHL2 (Gene) and FHL2 (Gene) is upregulated by Disulfiram (Compound)
Amprenavir may lead to a major life threatening interaction when taken with Methylprednisolone and Methylprednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disulfiram (Compound)
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Clindamycin and Clindamycin (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Disulfiram (Compound)
Amprenavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) regulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Disulfiram (Compound)