DDInter675 DDInter1852
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. The FDA withdrew its approval for the use of all parenteral dosage form drug products containing esmolol hydrochloride that supply 250 milligrams/milliliter of concentrated esmolol per 10-milliliter ampule. Other esmolol formulations are still available for use.
Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease.[L41855,L41860] The first agent approved for the treatment of PAH was [epoprostenol], a synthetic prostacyclin that significantly increases patients' quality of life. However, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature.[A248770,A248775] The use of more stable alternatives such as treprostinil provides patients with PAH with more treatment options. Treprostinil was approved by the FDA in 2002 for the treatment of pulmonary arterial hypertension. It is available in the following routes of administration: subcutaneous, intravenous, inhaled and oral. The first generic form of treprostinil became available in 2019.
Esmolol {u} (Compound) downregulates {v} (Gene) STX4
STX4 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Esmolol {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Esmolol {u} (Compound) binds {v} (Gene) ADRB2
ADRB2 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Esmolol {u} (Compound) downregulates {v} (Gene) POLG2
POLG2 {u} (Gene) is downregulated by {v} (Compound) Treprostinil
Esmolol {u} (Compound) causes {v} (Side Effect) Pain
Pain {u} (Side Effect) is caused by {v} (Compound) Treprostinil
Esmolol {u} (Compound) resembles {v} (Compound) Sotalol
Sotalol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Esmolol {u} (Compound) resembles {v} (Compound) Metoprolol
Metoprolol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Esmolol {u} (Compound) resembles {v} (Compound) Ibuprofen
Ibuprofen {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Treprostinil
Esmolol {u} (Compound) downregulates {v} (Gene) STX4
STX4 {u} (Gene) regulates {v} (Gene) HMOX1
HMOX1 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Esmolol {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is regulated by {v} (Gene) HDAC6
HDAC6 {u} (Gene) is upregulated by {v} (Compound) Treprostinil
Esmolol (Compound) downregulates STX4 (Gene) and STX4 (Gene) is upregulated by Treprostinil (Compound)
Esmolol (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Treprostinil (Compound)
Esmolol (Compound) binds ADRB2 (Gene) and ADRB2 (Gene) is downregulated by Treprostinil (Compound)
Esmolol (Compound) downregulates POLG2 (Gene) and POLG2 (Gene) is downregulated by Treprostinil (Compound)
Esmolol (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Treprostinil (Compound)
Esmolol (Compound) resembles Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil
Esmolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil
Esmolol (Compound) resembles Ibuprofen (Compound) and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil
Esmolol (Compound) downregulates STX4 (Gene) and STX4 (Gene) regulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Treprostinil (Compound)
Esmolol (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is regulated by HDAC6 (Gene) and HDAC6 (Gene) is upregulated by Treprostinil (Compound)