DDInter1678 DDInter957
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was extensively investigated as an immunosuppressive and antitumour agent. Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target for various diseases, as it was shown to regulate longevity and maintain normal glucose homeostasis. Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
Sirolimus {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Sirolimus {u} (Compound) causes {v} (Side Effect) Body temperature increased
Body temperature increased {u} (Side Effect) is caused by {v} (Compound) Diatrizoate
Diatrizoate {u} (Compound) resembles {v} (Compound) Iodipamide
Sirolimus {u} (Compound) downregulates {v} (Gene) PA2G4
PA2G4 {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Sirolimus {u} (Compound) downregulates {v} (Gene) PA2G4
PA2G4 {u} (Gene) regulates {v} (Gene) GRB7
GRB7 {u} (Gene) is downregulated by {v} (Compound) Iodipamide
Sirolimus {u} (Compound) upregulates {v} (Gene) AGA
AGA {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Sirolimus {u} (Compound) downregulates {v} (Gene) CDC45
CDC45 {u} (Gene) is regulated by {v} (Gene) NVL
NVL {u} (Gene) is downregulated by {v} (Compound) Iodipamide
Sirolimus {u} (Compound) upregulates {v} (Gene) ITGB5
ITGB5 {u} (Gene) interacts with {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norethisterone
Norethisterone {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Halothane
Halothane {u} (Compound) binds {v} (Gene) ALB
ALB {u} (Gene) is bound by {v} (Compound) Iodipamide
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Norethisterone
Norethisterone {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Iodipamide
Sirolimus (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Iodipamide (Compound)
Sirolimus (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Diatrizoate (Compound) and Diatrizoate (Compound) resembles Iodipamide (Compound)
Sirolimus (Compound) downregulates PA2G4 (Gene) and PA2G4 (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Sirolimus (Compound) downregulates PA2G4 (Gene) and PA2G4 (Gene) regulates GRB7 (Gene) and GRB7 (Gene) is downregulated by Iodipamide (Compound)
Sirolimus (Compound) upregulates AGA (Gene) and AGA (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Sirolimus (Compound) downregulates CDC45 (Gene) and CDC45 (Gene) is regulated by NVL (Gene) and NVL (Gene) is downregulated by Iodipamide (Compound)
Sirolimus (Compound) upregulates ITGB5 (Gene) and ITGB5 (Gene) interacts with ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Halothane and Halothane (Compound) binds ALB (Gene) and ALB (Gene) is bound by Iodipamide (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Iodipamide (Compound)