DDInter1447 DDInter1845
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Phentermine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) resembles {v} (Compound) Phenol
Phenol {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phendimetrazine
Phendimetrazine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phenelzine
Phenelzine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) causes {v} (Side Effect) Oedema
Oedema {u} (Side Effect) is caused by {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} (Compound) resembles {v} (Compound) Benzyl alcohol
Benzyl alcohol {u} (Compound) resembles {v} (Compound) Dextroamphetamine
Dextroamphetamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine {u} may lead to a major life threatening interaction when taken with {v} Phendimetrazine
Phendimetrazine {u} (Compound) resembles {v} (Compound) Fencamfamine
Fencamfamine {u} (Compound) resembles {v} (Compound) Tranylcypromine
Phentermine (Compound) resembles Tranylcypromine (Compound)
Phentermine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Tranylcypromine (Compound)
Phentermine (Compound) resembles Phenol (Compound) and Phenol (Compound) resembles Tranylcypromine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phendimetrazine and Phendimetrazine (Compound) resembles Tranylcypromine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Tranylcypromine (Compound)
Phentermine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Tranylcypromine (Compound)
Phentermine (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Tranylcypromine (Compound)
Phentermine (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Tranylcypromine (Compound)
Phentermine (Compound) resembles Benzyl alcohol (Compound) and Benzyl alcohol (Compound) resembles Dextroamphetamine (Compound) and Dextroamphetamine (Compound) resembles Tranylcypromine (Compound)
Phentermine may lead to a major life threatening interaction when taken with Phendimetrazine and Phendimetrazine (Compound) resembles Fencamfamine (Compound) and Fencamfamine (Compound) resembles Tranylcypromine (Compound)