DDInter305 DDInter278
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension. Carvedilol was granted FDA approval on 14 September 1995.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener . Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Carvedilol {u} (Compound) resembles {v} (Compound) Propafenone
Carvedilol {u} (Compound) resembles {v} (Compound) Bopindolol
Carvedilol {u} (Compound) treats {v} (Disease) hypertension
Carvedilol {u} (Compound) binds {v} (Gene) CYP1A1
Carvedilol {u} (Compound) upregulates {v} (Gene) INSIG1
Carvedilol {u} (Compound) is included by {v} (Pharmacologic Class) Adrenergic beta1-Antagonists
Carvedilol {u} (Compound) downregulates {v} (Gene) CDC20
Carvedilol {u} (Compound) causes {v} (Side Effect) Angina unstable
Carvedilol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Kaolin
Carvedilol {u} may cause a minor interaction that can limit clinical effects when taken with {v} Levothyroxine
Carvedilol (Compound) resembles Propafenone (Compound)
Carvedilol (Compound) resembles Bopindolol (Compound)
Carvedilol (Compound) treats hypertension (Disease)
Carvedilol (Compound) binds CYP1A1 (Gene)
Carvedilol (Compound) upregulates INSIG1 (Gene)
Carvedilol (Compound) is included by Adrenergic beta1-Antagonists (Pharmacologic Class)
Carvedilol (Compound) downregulates CDC20 (Gene)
Carvedilol (Compound) causes Angina unstable (Side Effect)
Carvedilol may cause a minor interaction that can limit clinical effects when taken with Kaolin
Carvedilol may cause a minor interaction that can limit clinical effects when taken with Levothyroxine