DDInter1607 DDInter52
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a booster of other protease inhibitors and is available in both liquid formulations and as capsules. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster. Ritonavir is a potent CYP3A inhibitor that increases peak and trough plasma drug concentrations of other protease inhibitors such as and overall drug exposure. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and
Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer due to numerous reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and death. In June 2002, the FDA approved a supplemental new drug application allowing the remarketing of the drug under restricted conditions of use.
Ritonavir {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Alosetron
Ritonavir {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Alosetron
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alosetron
Ritonavir {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Ondansetron
Ondansetron {u} (Compound) resembles {v} (Compound) Alosetron
Ritonavir {u} (Compound) causes {v} (Side Effect) Skin disorder
Skin disorder {u} (Side Effect) is caused by {v} (Compound) Ondansetron
Ondansetron {u} (Compound) resembles {v} (Compound) Alosetron
Ritonavir {u} (Compound) causes {v} (Side Effect) Jaundice
Jaundice {u} (Side Effect) is caused by {v} (Compound) Delavirdine
Delavirdine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alosetron
Ritonavir {u} (Compound) causes {v} (Side Effect) Colitis ulcerative
Colitis ulcerative {u} (Side Effect) is caused by {v} (Compound) Nefazodone
Nefazodone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Alosetron
Ritonavir {u} (Compound) causes {v} (Side Effect) Myalgia
Myalgia {u} (Side Effect) is caused by {v} (Compound) Procainamide
Procainamide {u} may cause a minor interaction that can limit clinical effects when taken with {v} Alosetron
Ritonavir {u} (Compound) causes {v} (Side Effect) Acne
Acne {u} (Side Effect) is caused by {v} (Compound) Fluvoxamine
Fluvoxamine {u} may lead to a major life threatening interaction when taken with {v} Alosetron
Ritonavir {u} (Compound) resembles {v} (Compound) Atazanavir
Atazanavir {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Alosetron
Ritonavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Alosetron (Compound)
Ritonavir (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Alosetron (Compound)
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Alosetron
Ritonavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Ondansetron (Compound) and Ondansetron (Compound) resembles Alosetron (Compound)
Ritonavir (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Ondansetron (Compound) and Ondansetron (Compound) resembles Alosetron (Compound)
Ritonavir (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Delavirdine (Compound) and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Alosetron
Ritonavir (Compound) causes Colitis ulcerative (Side Effect) and Colitis ulcerative (Side Effect) is caused by Nefazodone (Compound) and Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Alosetron
Ritonavir (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Procainamide (Compound) and Procainamide may cause a minor interaction that can limit clinical effects when taken with Alosetron
Ritonavir (Compound) causes Acne (Side Effect) and Acne (Side Effect) is caused by Fluvoxamine (Compound) and Fluvoxamine may lead to a major life threatening interaction when taken with Alosetron
Ritonavir (Compound) resembles Atazanavir (Compound) and Atazanavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Alosetron (Compound)