DDInter1791 DDInter130
A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for use in myocardial infarction, arrhythmias, and hypertension during the 1960s. Later they continued to be investigated for use in heart failure throughout the 1970-1980s. Atenolol itself was developed early on in this history by Alvogen Malta under the trade name Tenormin and received FDA approval in September, 1981.[label] Despite being one of the most widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and only modestly reduce the risk of cardiovascular disease in patients with hypertension.[A235850,A235855] A Cochrane review of patients being treated for primary hypertension shows that atenolol shows a risk ratio of 0.88 for cardiovascular disease risk and a risk ratio of 0.99 for mortality.[A235850,A235855] Similar results have been found in other meta-analyses.[A235860,A235865] A meta-analysis of over 145,000 patients showed the risk of stroke in patients taking atenolol may depend on the age of the patient. The use of atenolol may need to be based on more patient factors than hypertension alone.[A235850,A235855,A235860,A235865]
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Metoprolol
Metoprolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Betaxolol
Betaxolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} (Compound) upregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Atenolol
Theophylline {u} (Compound) causes {v} (Side Effect) Dizziness
Dizziness {u} (Side Effect) is caused by {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Pindolol
Pindolol {u} (Compound) resembles {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Sotalol
Sotalol {u} (Compound) resembles {v} (Compound) Practolol
Practolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Metoprolol
Metoprolol {u} (Compound) resembles {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline {u} may lead to a major life threatening interaction when taken with {v} Acebutolol
Acebutolol {u} (Compound) resembles {v} (Compound) Oxprenolol
Oxprenolol {u} (Compound) resembles {v} (Compound) Atenolol
Theophylline may lead to a major life threatening interaction when taken with Pindolol and Pindolol (Compound) resembles Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Metoprolol and Metoprolol (Compound) resembles Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Betaxolol and Betaxolol (Compound) resembles Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Acebutolol and Acebutolol (Compound) resembles Atenolol (Compound)
Theophylline (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Atenolol (Compound)
Theophylline (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Pindolol and Pindolol (Compound) resembles Oxprenolol (Compound) and Oxprenolol (Compound) resembles Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Sotalol and Sotalol (Compound) resembles Practolol (Compound) and Practolol (Compound) resembles Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Metoprolol and Metoprolol (Compound) resembles Oxprenolol (Compound) and Oxprenolol (Compound) resembles Atenolol (Compound)
Theophylline may lead to a major life threatening interaction when taken with Acebutolol and Acebutolol (Compound) resembles Oxprenolol (Compound) and Oxprenolol (Compound) resembles Atenolol (Compound)