DDInter1158 DDInter1179
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) In the US, methoxyflurane is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness.
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Mesalazine {u} (Compound) resembles {v} (Compound) Dopamine
Dopamine {u} (Compound) binds {v} (Gene) CYP1A2
CYP1A2 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Streptomycin
Streptomycin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Mesalazine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is regulated by {v} (Gene) ATP2C1
ATP2C1 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Mesalazine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is regulated by {v} (Gene) ATP2C1
ATP2C1 {u} (Gene) is bound by {v} (Compound) Methoxyflurane
Mesalazine {u} (Compound) downregulates {v} (Gene) TNIP1
TNIP1 {u} (Gene) is downregulated by {v} (Compound) Diclofenac
Diclofenac {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Mesalazine {u} (Compound) upregulates {v} (Gene) COL11A1
COL11A1 {u} (Gene) is upregulated by {v} (Compound) Sirolimus
Sirolimus {u} may lead to a major life threatening interaction when taken with {v} Methoxyflurane
Mesalazine {u} (Compound) resembles {v} (Compound) Dopamine
Dopamine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Exenatide
Exenatide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Mesalazine {u} (Compound) resembles {v} (Compound) Olsalazine
Olsalazine {u} (Compound) resembles {v} (Compound) Sulfasalazine
Sulfasalazine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Methoxyflurane
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Mesalazine (Compound) resembles Dopamine (Compound) and Dopamine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Methoxyflurane (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Mesalazine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is regulated by ATP2C1 (Gene) and ATP2C1 (Gene) is bound by Methoxyflurane (Compound)
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Mesalazine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is regulated by ATP2C1 (Gene) and ATP2C1 (Gene) is bound by Methoxyflurane (Compound)
Mesalazine (Compound) downregulates TNIP1 (Gene) and TNIP1 (Gene) is downregulated by Diclofenac (Compound) and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Mesalazine (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Sirolimus (Compound) and Sirolimus may lead to a major life threatening interaction when taken with Methoxyflurane
Mesalazine (Compound) resembles Dopamine (Compound) and Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane
Mesalazine (Compound) resembles Olsalazine (Compound) and Olsalazine (Compound) resembles Sulfasalazine (Compound) and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Methoxyflurane