DDInter336 DDInter1079
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in the colon. It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval in 1998. Interestingly, selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies.
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Lisinopril was granted FDA approval on 29 December 1987.
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is treated by {v} (Compound) Lisinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Lisinopril
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) downregulates {v} (Gene) ABCB1
ABCB1 {u} (Gene) is bound by {v} (Compound) Lisinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Somnolence
Somnolence {u} (Side Effect) is caused by {v} (Compound) Enalapril
Enalapril {u} (Compound) resembles {v} (Compound) Lisinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Bladder pain
Bladder pain {u} (Side Effect) is caused by {v} (Compound) Sirolimus
Sirolimus {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lisinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Osteoarthritis
Osteoarthritis {u} (Side Effect) is caused by {v} (Compound) Trandolapril
Trandolapril {u} (Compound) resembles {v} (Compound) Lisinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Fluid retention
Fluid retention {u} (Side Effect) is caused by {v} (Compound) Sodium bicarbonate
Sodium bicarbonate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Lisinopril
Celecoxib {u} (Compound) causes {v} (Side Effect) Breast pain
Breast pain {u} (Side Effect) is caused by {v} (Compound) Epirubicin
Epirubicin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Lisinopril
Celecoxib {u} (Compound) resembles {v} (Compound) Etoricoxib
Etoricoxib {u} (Compound) causes {v} (Side Effect) Bronchitis
Bronchitis {u} (Side Effect) is caused by {v} (Compound) Lisinopril
Celecoxib {u} (Compound) palliates {v} (Disease) systemic scleroderma
systemic scleroderma {u} (Disease) is associated with {v} (Gene) ACE
ACE {u} (Gene) is bound by {v} (Compound) Lisinopril
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is treated by Lisinopril (Compound)
Celecoxib (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Lisinopril (Compound)
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) downregulates ABCB1 (Gene) and ABCB1 (Gene) is bound by Lisinopril (Compound)
Celecoxib (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Enalapril (Compound) and Enalapril (Compound) resembles Lisinopril (Compound)
Celecoxib (Compound) causes Bladder pain (Side Effect) and Bladder pain (Side Effect) is caused by Sirolimus (Compound) and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril
Celecoxib (Compound) causes Osteoarthritis (Side Effect) and Osteoarthritis (Side Effect) is caused by Trandolapril (Compound) and Trandolapril (Compound) resembles Lisinopril (Compound)
Celecoxib (Compound) causes Fluid retention (Side Effect) and Fluid retention (Side Effect) is caused by Sodium bicarbonate (Compound) and Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Lisinopril
Celecoxib (Compound) causes Breast pain (Side Effect) and Breast pain (Side Effect) is caused by Epirubicin (Compound) and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril
Celecoxib (Compound) resembles Etoricoxib (Compound) and Etoricoxib (Compound) causes Bronchitis (Side Effect) and Bronchitis (Side Effect) is caused by Lisinopril (Compound)
Celecoxib (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is associated with ACE (Gene) and ACE (Gene) is bound by Lisinopril (Compound)