DDInter1868 DDInter150
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and 2. The combination product of trifluridine with tipiracil marketed as Lonsurf has been approved in Japan, the United States, and the European Union for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In the anticancer therapy, trifluridine acts as a thymidine-based nucleoside metabolic inhibitor that gets
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. Azathiprine was granted FDA approval on 20 March 1968.
Trifluridine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Trifluridine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Trifluridine {u} (Compound) causes {v} (Side Effect) Nausea
Nausea {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Trifluridine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HPRT1
HPRT1 {u} (Gene) is bound by {v} (Compound) Azathioprine
Trifluridine {u} (Compound) resembles {v} (Compound) Telbivudine
Telbivudine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleoside Analog
Nucleoside Analog {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Trifluridine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) HSD17B11
HSD17B11 {u} (Gene) is upregulated by {v} (Compound) Azathioprine
Trifluridine {u} (Compound) resembles {v} (Compound) Pentostatin
Pentostatin {u} (Compound) is included by {v} (Pharmacologic Class) Nucleic Acid Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Trifluridine {u} (Compound) resembles {v} (Compound) Telbivudine
Telbivudine {u} (Compound) causes {v} (Side Effect) Vomiting
Vomiting {u} (Side Effect) is caused by {v} (Compound) Azathioprine
Trifluridine {u} (Compound) downregulates {v} (Gene) PLK1
PLK1 {u} (Gene) regulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Azathioprine
Trifluridine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Zidovudine
Zidovudine {u} (Compound) is included by {v} (Pharmacologic Class) Nucleoside Analog
Nucleoside Analog {u} (Pharmacologic Class) includes {v} (Compound) Azathioprine
Trifluridine (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) and Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) includes Azathioprine (Compound)
Trifluridine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) is downregulated by Azathioprine (Compound)
Trifluridine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Azathioprine (Compound)
Trifluridine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HPRT1 (Gene) and HPRT1 (Gene) is bound by Azathioprine (Compound)
Trifluridine (Compound) resembles Telbivudine (Compound) and Telbivudine (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Azathioprine (Compound)
Trifluridine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates HSD17B11 (Gene) and HSD17B11 (Gene) is upregulated by Azathioprine (Compound)
Trifluridine (Compound) resembles Pentostatin (Compound) and Pentostatin (Compound) is included by Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) and Nucleic Acid Synthesis Inhibitors (Pharmacologic Class) includes Azathioprine (Compound)
Trifluridine (Compound) resembles Telbivudine (Compound) and Telbivudine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Azathioprine (Compound)
Trifluridine (Compound) downregulates PLK1 (Gene) and PLK1 (Gene) regulates RPIA (Gene) and RPIA (Gene) is downregulated by Azathioprine (Compound)
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Azathioprine (Compound)