DDInter1233 DDInter664
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the management of Cushing's syndrome.
An ergot alkaloid with uterine and vascular smooth muscle contractile properties.
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Ergometrine
Mitotane {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Ergometrine
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) regulates {v} (Gene) C2CD2
C2CD2 {u} (Gene) is upregulated by {v} (Compound) Ergometrine
Mitotane {u} (Compound) causes {v} (Side Effect) Vertigo
Vertigo {u} (Side Effect) is caused by {v} (Compound) Lisuride
Lisuride {u} (Compound) resembles {v} (Compound) Ergometrine
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergometrine
Mitotane {u} (Compound) downregulates {v} (Gene) FAM69A
FAM69A {u} (Gene) is downregulated by {v} (Compound) Dexamethasone
Dexamethasone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergometrine
Mitotane {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Pazopanib
Pazopanib {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergometrine
Mitotane {u} (Compound) causes {v} (Side Effect) Shock
Shock {u} (Side Effect) is caused by {v} (Compound) Bicalutamide
Bicalutamide {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ergometrine
Mitotane {u} (Compound) resembles {v} (Compound) Carbinoxamine
Carbinoxamine {u} (Compound) binds {v} (Gene) CYP3A4
CYP3A4 {u} (Gene) is bound by {v} (Compound) Ergometrine
Mitotane {u} (Compound) causes {v} (Side Effect) Hypotension
Hypotension {u} (Side Effect) is caused by {v} (Compound) Phenylpropanolamine
Phenylpropanolamine {u} may lead to a major life threatening interaction when taken with {v} Ergometrine
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Ergometrine (Compound)
Mitotane (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Ergometrine (Compound)
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) regulates C2CD2 (Gene) and C2CD2 (Gene) is upregulated by Ergometrine (Compound)
Mitotane (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Lisuride (Compound) and Lisuride (Compound) resembles Ergometrine (Compound)
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Ergometrine
Mitotane (Compound) downregulates FAM69A (Gene) and FAM69A (Gene) is downregulated by Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ergometrine
Mitotane (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Pazopanib (Compound) and Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Ergometrine
Mitotane (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Bicalutamide (Compound) and Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Ergometrine
Mitotane (Compound) resembles Carbinoxamine (Compound) and Carbinoxamine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ergometrine (Compound)
Mitotane (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Phenylpropanolamine (Compound) and Phenylpropanolamine may lead to a major life threatening interaction when taken with Ergometrine