DDInter458 DDInter1927
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz).[L11097,L3734,L11118]
Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder in adults. The immediate formulation of the drug, marketed as Effexor, was first approved by the FDA in 1993 and the extended-release formulation, Effexor XR, was later introduced in 1997. Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years. It was also considered a second-line treatment for obsessive-compulsive disorder (OCD).[A177226,A177235] Venlafaxine was also investigated in off-label uses for the prophylaxis of migraine headaches,[A413,A177229] for reduction of vasomotor symptoms associated with menopause, and for the management of neuropathic pain (although there is only minimal evidence of efficacy for this condition).
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Venlafaxine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Diabetes mellitus
Diabetes mellitus {u} (Side Effect) is caused by {v} (Compound) Venlafaxine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Venlafaxine
Cyclosporine {u} (Compound) binds {v} (Gene) ABCG2
ABCG2 {u} (Gene) is bound by {v} (Compound) Oxaliplatin
Oxaliplatin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venlafaxine
Cyclosporine {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Tramadol
Tramadol {u} (Compound) resembles {v} (Compound) Venlafaxine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Diabetes mellitus
Diabetes mellitus {u} (Side Effect) is caused by {v} (Compound) Tramadol
Tramadol {u} (Compound) resembles {v} (Compound) Venlafaxine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Leukorrhea
Leukorrhea {u} (Side Effect) is caused by {v} (Compound) Metronidazole
Metronidazole {u} may cause a minor interaction that can limit clinical effects when taken with {v} Venlafaxine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Weight increased
Weight increased {u} (Side Effect) is caused by {v} (Compound) Desvenlafaxine
Desvenlafaxine {u} (Compound) resembles {v} (Compound) Venlafaxine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Trauma
Trauma {u} (Side Effect) is caused by {v} (Compound) Formoterol
Formoterol {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venlafaxine
Cyclosporine {u} (Compound) causes {v} (Side Effect) Libido increased
Libido increased {u} (Side Effect) is caused by {v} (Compound) Goserelin
Goserelin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Venlafaxine
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Venlafaxine (Compound)
Cyclosporine (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Venlafaxine (Compound)
Cyclosporine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Venlafaxine
Cyclosporine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Oxaliplatin (Compound) and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine
Cyclosporine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Tramadol (Compound) and Tramadol (Compound) resembles Venlafaxine (Compound)
Cyclosporine (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Tramadol (Compound) and Tramadol (Compound) resembles Venlafaxine (Compound)
Cyclosporine (Compound) causes Leukorrhea (Side Effect) and Leukorrhea (Side Effect) is caused by Metronidazole (Compound) and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Venlafaxine
Cyclosporine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Desvenlafaxine (Compound) and Desvenlafaxine (Compound) resembles Venlafaxine (Compound)
Cyclosporine (Compound) causes Trauma (Side Effect) and Trauma (Side Effect) is caused by Formoterol (Compound) and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine
Cyclosporine (Compound) causes Libido increased (Side Effect) and Libido increased (Side Effect) is caused by Goserelin (Compound) and Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine