DDInter1465 DDInter1376
A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by pilocarpine dates back to 1875.
Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) and was approved by the FDA on March 26, 2020.[L12573,L12582] The US approval was followed by the approval in Canada on October 2, 2020. In November 2021, ozanimod was also approved by the European Commission for the treatment of adults with relapsing remitting multiple sclerosis.[L39377,L39382] MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Inflammatory bowel disease also a chronic inflammatory condition and can cause persistent abdominal pain, diarrhea, bloody stools, and vomiting. In clinical trials, Ozanimod has been shown to be well-tolerated and has resulted in a higher decrease in the rate of MS relapses than with intramuscular [interferon beta-1a], a current standard in MS therapy. Studies involving patients with inflammatory bowel disease have also shown promising results.[A189318,A189342]
Pilocarpine {u} (Compound) treats {v} (Disease) glaucoma
Pilocarpine {u} (Compound) binds {v} (Gene) CHRM1
Pilocarpine {u} (Compound) upregulates {v} (Gene) PRKX
Pilocarpine {u} (Compound) palliates {v} (Disease) head and neck cancer
Pilocarpine {u} (Compound) is included by {v} (Pharmacologic Class) Cholinergic Muscarinic Agonists
Pilocarpine {u} (Compound) downregulates {v} (Gene) DLD
Pilocarpine {u} (Compound) causes {v} (Side Effect) Eye disorder
Pilocarpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dicyclomine
Pilocarpine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aclidinium
Pilocarpine (Compound) treats glaucoma (Disease)
Pilocarpine (Compound) binds CHRM1 (Gene)
Pilocarpine (Compound) upregulates PRKX (Gene)
Pilocarpine (Compound) palliates head and neck cancer (Disease)
Pilocarpine (Compound) is included by Cholinergic Muscarinic Agonists (Pharmacologic Class)
Pilocarpine (Compound) downregulates DLD (Gene)
Pilocarpine (Compound) causes Eye disorder (Side Effect)
Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine
Pilocarpine may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium