DDInter1619 DDInter959
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
Ropinirole {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Ioflupane I-123
Ropinirole {u} (Compound) causes {v} (Side Effect) Dysgeusia
Dysgeusia {u} (Side Effect) is caused by {v} (Compound) Duloxetine
Duloxetine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) interacts with {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Ioflupane I-123
Ropinirole {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is associated with {v} (Gene) SLC6A3
SLC6A3 {u} (Gene) is bound by {v} (Compound) Ioflupane I-123
Ropinirole {u} (Compound) binds {v} (Gene) DRD2
DRD2 {u} (Gene) is bound by {v} (Compound) Fenoldopam
Fenoldopam {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole {u} (Compound) palliates {v} (Disease) Parkinson's disease
Parkinson's disease {u} (Disease) is palliated by {v} (Compound) Amantadine
Amantadine {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole {u} (Compound) causes {v} (Side Effect) Hypersensitivity
Hypersensitivity {u} (Side Effect) is caused by {v} (Compound) Cocaine
Cocaine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole {u} (Compound) binds {v} (Gene) CYP2D6
CYP2D6 {u} (Gene) is bound by {v} (Compound) Cocaine
Cocaine {u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole {u} (Compound) downregulates {v} (Gene) PPP2R5E
PPP2R5E {u} (Gene) is downregulated by {v} (Compound) Iloperidone
Iloperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole {u} (Compound) downregulates {v} (Gene) UBQLN2
UBQLN2 {u} (Gene) is upregulated by {v} (Compound) Risperidone
Risperidone {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Ioflupane I-123
Ropinirole (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Ropinirole (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Duloxetine (Compound) and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ropinirole (Compound) binds DRD2 (Gene) and DRD2 (Gene) interacts with SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Ioflupane I-123 (Compound)
Ropinirole (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is associated with SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Ioflupane I-123 (Compound)
Ropinirole (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Fenoldopam (Compound) and Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ropinirole (Compound) palliates Parkinson's disease (Disease) and Parkinson's disease (Disease) is palliated by Amantadine (Compound) and Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ropinirole (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Cocaine (Compound) and Cocaine (Compound) resembles Ioflupane I-123 (Compound) and Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ropinirole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Cocaine (Compound) and Cocaine (Compound) resembles Ioflupane I-123 (Compound) and Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ropinirole (Compound) downregulates PPP2R5E (Gene) and PPP2R5E (Gene) is downregulated by Iloperidone (Compound) and Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ropinirole (Compound) downregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Risperidone (Compound) and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123