DDInter542 DDInter829
Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to nonsteroidal anti-inflammatory drugs treating the painful symptoms of OA. Glucosamine is commonly used over the counter as a treatment for arthritic joint pain, although its acceptance as a medical therapy varies due to contradictory and findings with unclear clinical significance during clinical trials.[A231894,A232289] It is currently not approved as a prescription product by the FDA, but is widely available over the counter.
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glucosamine
Dicoumarol {u} (Compound) resembles {v} (Compound) Phenprocoumon
Phenprocoumon {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glucosamine
Dicoumarol {u} (Compound) resembles {v} (Compound) Warfarin
Warfarin {u} (Compound) binds {v} (Gene) CYP2C19
CYP2C19 {u} (Gene) is bound by {v} (Compound) Glucosamine
Dicoumarol {u} (Compound) binds {v} (Gene) CYP2C9
CYP2C9 {u} (Gene) is bound by {v} (Compound) Warfarin
Warfarin {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Glucosamine
Dicoumarol {u} (Compound) binds {v} (Gene) NQO1
NQO1 {u} (Gene) regulates {v} (Gene) SUPV3L1
SUPV3L1 {u} (Gene) is downregulated by {v} (Compound) Glucosamine
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) is regulated by {v} (Gene) IFNG
IFNG {u} (Gene) is bound by {v} (Compound) Glucosamine
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) is downregulated by {v} (Compound) Azacitidine
Azacitidine {u} (Compound) resembles {v} (Compound) Glucosamine
Dicoumarol {u} (Compound) downregulates {v} (Gene) P4HTM
P4HTM {u} (Gene) regulates {v} (Gene) PUF60
PUF60 {u} (Gene) is downregulated by {v} (Compound) Glucosamine
Dicoumarol {u} (Compound) binds {v} (Gene) CRYZ
CRYZ {u} (Gene) regulates {v} (Gene) PNKP
PNKP {u} (Gene) is upregulated by {v} (Compound) Glucosamine
Dicoumarol {u} (Compound) downregulates {v} (Gene) POLR2I
POLR2I {u} (Gene) regulates {v} (Gene) PNKP
PNKP {u} (Gene) is upregulated by {v} (Compound) Glucosamine
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Glucosamine
Dicoumarol (Compound) resembles Phenprocoumon (Compound) and Phenprocoumon (Compound) resembles Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Glucosamine
Dicoumarol (Compound) resembles Warfarin (Compound) and Warfarin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Glucosamine (Compound)
Dicoumarol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Warfarin (Compound) and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Glucosamine
Dicoumarol (Compound) binds NQO1 (Gene) and NQO1 (Gene) regulates SUPV3L1 (Gene) and SUPV3L1 (Gene) is downregulated by Glucosamine (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) is regulated by IFNG (Gene) and IFNG (Gene) is bound by Glucosamine (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) is downregulated by Azacitidine (Compound) and Azacitidine (Compound) resembles Glucosamine (Compound)
Dicoumarol (Compound) downregulates P4HTM (Gene) and P4HTM (Gene) regulates PUF60 (Gene) and PUF60 (Gene) is downregulated by Glucosamine (Compound)
Dicoumarol (Compound) binds CRYZ (Gene) and CRYZ (Gene) regulates PNKP (Gene) and PNKP (Gene) is upregulated by Glucosamine (Compound)
Dicoumarol (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) regulates PNKP (Gene) and PNKP (Gene) is upregulated by Glucosamine (Compound)