DDInter1149 DDInter1651
Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system . Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Dextropropoxyphene
Mepenzolate {u} (Compound) resembles {v} (Compound) Fexofenadine
Mepenzolate {u} (Compound) resembles {v} (Compound) Diphemanil Methylsulfate
Mepenzolate {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Aclidinium
Mepenzolate {u} (Compound) binds {v} (Gene) CHRM1
Mepenzolate {u} (Compound) upregulates {v} (Gene) SGCB
Mepenzolate {u} (Compound) is included by {v} (Pharmacologic Class) Cholinergic Antagonists
Mepenzolate {u} (Compound) downregulates {v} (Gene) DLD
Mepenzolate {u} (Compound) causes {v} (Side Effect) Bloated feeling
Mepenzolate {u} may cause a minor interaction that can limit clinical effects when taken with {v} Indapamide
Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene
Mepenzolate (Compound) resembles Fexofenadine (Compound)
Mepenzolate (Compound) resembles Diphemanil Methylsulfate (Compound)
Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Mepenzolate (Compound) binds CHRM1 (Gene)
Mepenzolate (Compound) upregulates SGCB (Gene)
Mepenzolate (Compound) is included by Cholinergic Antagonists (Pharmacologic Class)
Mepenzolate (Compound) downregulates DLD (Gene)
Mepenzolate (Compound) causes Bloated feeling (Side Effect)
Mepenzolate may cause a minor interaction that can limit clinical effects when taken with Indapamide