DDInter1619 DDInter459
Ropinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label],. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome. In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole.
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Ropinirole {u} (Compound) binds {v} (Gene) HTR1A
HTR1A {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) causes {v} (Side Effect) Agranulocytosis
Agranulocytosis {u} (Side Effect) is caused by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) binds {v} (Gene) HTR1A
HTR1A {u} (Gene) is bound by {v} (Compound) Nortriptyline
Nortriptyline {u} (Compound) resembles {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) binds {v} (Gene) HTR2C
HTR2C {u} (Gene) is bound by {v} (Compound) Metixene
Metixene {u} (Compound) resembles {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) downregulates {v} (Gene) RBM34
RBM34 {u} (Gene) is regulated by {v} (Gene) SIRT1
SIRT1 {u} (Gene) is upregulated by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) upregulates {v} (Gene) RRP8
RRP8 {u} (Gene) is regulated by {v} (Gene) HRH1
HRH1 {u} (Gene) is bound by {v} (Compound) Cyproheptadine
Ropinirole {u} (Compound) downregulates {v} (Gene) HAT1
HAT1 {u} (Gene) is downregulated by {v} (Compound) Protriptyline
Protriptyline {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Cyproheptadine
Ropinirole (Compound) binds HTR1A (Gene) and HTR1A (Gene) is bound by Cyproheptadine (Compound)
Ropinirole (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is upregulated by Cyproheptadine (Compound)
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Cyproheptadine (Compound)
Ropinirole (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Cyproheptadine (Compound)
Ropinirole (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Cyproheptadine (Compound)
Ropinirole (Compound) binds HTR1A (Gene) and HTR1A (Gene) is bound by Nortriptyline (Compound) and Nortriptyline (Compound) resembles Cyproheptadine (Compound)
Ropinirole (Compound) binds HTR2C (Gene) and HTR2C (Gene) is bound by Metixene (Compound) and Metixene (Compound) resembles Cyproheptadine (Compound)
Ropinirole (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is regulated by SIRT1 (Gene) and SIRT1 (Gene) is upregulated by Cyproheptadine (Compound)
Ropinirole (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is regulated by HRH1 (Gene) and HRH1 (Gene) is bound by Cyproheptadine (Compound)
Ropinirole (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Protriptyline (Compound) and Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine