DDInter1174 DDInter704
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma.[A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Everolimus
Methotrexate {u} (Compound) upregulates {v} (Gene) CCDC85B
CCDC85B {u} (Gene) is upregulated by {v} (Compound) Everolimus
Methotrexate {u} (Compound) downregulates {v} (Gene) HSPA1A
HSPA1A {u} (Gene) is upregulated by {v} (Compound) Everolimus
Methotrexate {u} (Compound) downregulates {v} (Gene) RPIA
RPIA {u} (Gene) is downregulated by {v} (Compound) Everolimus
Methotrexate {u} (Compound) upregulates {v} (Gene) PRSS23
PRSS23 {u} (Gene) is downregulated by {v} (Compound) Everolimus
Methotrexate {u} (Compound) binds {v} (Gene) ATIC
ATIC {u} (Gene) is downregulated by {v} (Compound) Everolimus
Methotrexate {u} (Compound) causes {v} (Side Effect) Pericardial effusion
Pericardial effusion {u} (Side Effect) is caused by {v} (Compound) Everolimus
Methotrexate {u} may lead to a major life threatening interaction when taken with {v} Sirolimus
Sirolimus {u} (Compound) resembles {v} (Compound) Pimecrolimus
Pimecrolimus {u} (Compound) resembles {v} (Compound) Everolimus
Methotrexate {u} (Compound) upregulates {v} (Gene) CCDC85B
CCDC85B {u} (Gene) covaries with {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Methotrexate {u} (Compound) upregulates {v} (Gene) NFKBIA
NFKBIA {u} (Gene) regulates {v} (Gene) MCOLN1
MCOLN1 {u} (Gene) is upregulated by {v} (Compound) Everolimus
Methotrexate may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Everolimus (Compound)
Methotrexate (Compound) upregulates CCDC85B (Gene) and CCDC85B (Gene) is upregulated by Everolimus (Compound)
Methotrexate (Compound) downregulates HSPA1A (Gene) and HSPA1A (Gene) is upregulated by Everolimus (Compound)
Methotrexate (Compound) downregulates RPIA (Gene) and RPIA (Gene) is downregulated by Everolimus (Compound)
Methotrexate (Compound) upregulates PRSS23 (Gene) and PRSS23 (Gene) is downregulated by Everolimus (Compound)
Methotrexate (Compound) binds ATIC (Gene) and ATIC (Gene) is downregulated by Everolimus (Compound)
Methotrexate (Compound) causes Pericardial effusion (Side Effect) and Pericardial effusion (Side Effect) is caused by Everolimus (Compound)
Methotrexate may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus (Compound) resembles Pimecrolimus (Compound) and Pimecrolimus (Compound) resembles Everolimus (Compound)
Methotrexate (Compound) upregulates CCDC85B (Gene) and CCDC85B (Gene) covaries with MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Everolimus (Compound)
Methotrexate (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) regulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Everolimus (Compound)