DDInter948 DDInter638
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that suppresses the renin-angiotensin-aldosterone system to lower blood pressure. It was developed from a targeted research programmed using molecular modelling. Being a prodrug, enalapril is rapidly biotransformed into its active metabolite, [enalaprilat], which is responsible for the pharmacological actions of enalapril. The active metabolite of enalapril competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the renin-angiotensin-aldosterone system that promotes vasoconstriction and renal reabsorption of sodium ions in the kidneys. Ultimately, enalaprilat works to reduce blood pressure and blood fluid volume. Commonly marketed under the trade name Vasotec, enalapril was first approved by the FDA in 1985 for the management of hypertension, heart failure, and asymptomatic left ventricular dysfunction. It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension. The active metabolite enalaprilat is also available in oral tablets and intravenous formulations for injection.
Enalapril {u} (Compound) resembles {v} (Compound) Fosinopril
Enalapril {u} (Compound) resembles {v} (Compound) Ramipril
Enalapril {u} may cause a moderate interaction that could exacerbate diseases when taken with {v} Nateglinide
Enalapril {u} (Compound) treats {v} (Disease) coronary artery disease
Enalapril {u} (Compound) binds {v} (Gene) SLC22A7
Enalapril {u} (Compound) upregulates {v} (Gene) LAMA3
Enalapril {u} (Compound) is included by {v} (Pharmacologic Class) Decreased Blood Pressure
Enalapril {u} (Compound) downregulates {v} (Gene) BUB1B
Enalapril {u} (Compound) causes {v} (Side Effect) Serum creatinine increased
Enalapril {u} may cause a minor interaction that can limit clinical effects when taken with {v} Sodium citrate
Enalapril (Compound) resembles Fosinopril (Compound)
Enalapril (Compound) resembles Ramipril (Compound)
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Enalapril (Compound) treats coronary artery disease (Disease)
Enalapril (Compound) binds SLC22A7 (Gene)
Enalapril (Compound) upregulates LAMA3 (Gene)
Enalapril (Compound) is included by Decreased Blood Pressure (Pharmacologic Class)
Enalapril (Compound) downregulates BUB1B (Gene)
Enalapril (Compound) causes Serum creatinine increased (Side Effect)
Enalapril may cause a minor interaction that can limit clinical effects when taken with Sodium citrate