text: ABSTRACT Neutrophilic dermatosis is a spectrum of skin disorders that include several rare diseases such as Sweet?s syndrome, pyoderma gangrenosum and subcorneal pustular dermatosis [1]. The treatment options for these rare diseases hallmarked by skin lesions filled with neutrophils are limited to the use of strong immunosuppressive, which are non-specific and have adverse side effects. Thus, specific novel therapeutic targets are much needed to help patients suffering from these disorders. Mice carrying a single point mutation in the Ptpn6 gene that results in a Y208N substitution in the Ptpn6 encoded SHP1 protein (known as Ptpn6spin mice), develop spontaneous footpad inflammation that mimics neutrophilic dermatosis. We have extensively studied Ptpn6spin mice and identified several novel therapeutic targets including IL-1 alpha, RIPK1, SYK and TAK1, that can be potentially beneficial to neutrophilic dermatosis patients [2]. Building upon these prior discoveries, we have set our goals to elucidate the role of an integrin-associated protein, CD47, and its crosstalk with SHP1 in regulating autoinflammatory disease and health. CD47 is ubiquitously expressed in the human body and provides a ?don?t eat me? signal to the phagocytic cells [3, 4]. Our preliminary data show a crucial role for CD47 in regulating disease observed in Ptpn6spin mice; however, the cellular and molecular mechanisms remain unknown. Understanding the cellular and molecular basis of these pathologies will not only enhance our general understanding of CD47 and SHP1 biology, but also aid in the development of potential novel therapies for inflammation and cancer.

textbook:
Lesson: Introduction to Neutrophilic Dermatosis

### Section 1: What is Neutrophilic Dermatosis?
Neutrophilic dermatosis is a group of rare skin disorders characterized by the presence of neutrophils, a type of white blood cell, in the skin. These disorders include Sweet's syndrome, pyoderma gangrenosum, and subcorneal pustular dermatitis. They are often accompanied by symptoms such as pain, itching, and redness.

### Section 2: Causes and Symptoms
The exact cause of neutrophilic dermatosis is not well understood, but it is believed to involve an overactive immune system. Some people may have a genetic predisposition to developing these disorders. Symptoms can vary depending on the specific type of neutrophilic dermatosis, but generally include skin lesions filled with neutrophils, as well as swelling, tenderness, and itching.

### Section 3: Treatment and Prevention
Treatment options for neutrophilic dermatosis are limited, as they often involve the use of strong immunosuppressive medications with potential side effects. Researchers are working to identify new therapeutic targets to improve treatment options for those affected by these disorders. In addition, prevention strategies may include managing underlying health conditions that may contribute to the development of neutrophilic dermatosis, as well as avoiding triggers that may exacerbate symptoms.

### Section 4: Conclusion
Understanding neutrophilic dermatosis and its potential causes and treatments is important for anyone who may be at risk for developing these disorders. By learning more about this condition, individuals can work with their healthcare providers to develop a comprehensive treatment plan that addresses their specific needs and concerns. Additionally, ongoing research efforts may lead to the discovery of new therapeutic targets and improved treatment options for those affected by neutrophilic dermatosis.


text: Educational Services. It is easy:. For all full time A non refundable R1500 registration fee gets u a seat on any of the programs.. For all Tuition learner’s a R500 non refundable registration fee gets you online.. Prices for each program differ that’s to be discussed on registration or when enquiring online. Our prices are reasonably affordable when comparing with other institutions.

source: refinedweb

textbook:
Lesson: Introduction to Mathematics

## Section 1: What is Mathematics?
Mathematics is the study of numbers, quantities, structures, and relationships. It is a fundamental subject that is used in everyday life, science, engineering, and many other fields.

## Section 2: Why is Mathematics Important?
Mathematics is important because it helps us understand the world around us. It allows us to make sense of complex data and patterns, and to make informed decisions based on evidence and logic. Mathematics is also essential for many careers, including engineering, finance, and teaching.

## Section 3: How does Mathematics Work?
Mathematics works by using logical and systematic methods to solve problems. It involves using symbols, equations, and formulas to represent and analyze data. Mathematics can be used to prove theorems, which are statements that can be proven true or false based on the available evidence.

## Section 4: Practical Examples
Here are some practical examples of how mathematics can be used:

1. Calculating area: If you want to find the area of a rectangle, you can use the formula A = L x W, where A is the area, L is the length, and W is the width.
2. Calculating interest: If you deposit R1000 into a savings account that earns 5% interest per year, how much money will you have after 5 years? You can use the formula A = P(r^n), where A is the future value, P is the principal, r is the annual interest rate, n is the number of years, and e is Euler's number (approximately 2.71828).
3. Analyzing data: If you have a dataset with 1000 observations, you can use statistical methods to analyze the data and draw conclusions about the population.

## Glossary
- Area: The amount of space inside a two-dimensional shape
- Interest: Money earned on an investment or deposit
- Principal: The original amount of money invested or deposited
- Annual interest rate: The percentage of the principal that is earned as interest per year
- Population: All the individuals of a particular species within a specific area
- Dataset: A collection of data that is organized and labeled

## Conclusion
Mathematics is a powerful tool that can be used to understand the world around us. By learning the basics of mathematics, we can make better decisions, analyze data, and solve problems. By applying the principles of mathematics to real-world scenarios, we can gain valuable insights and develop critical thinking skills.


text:
Q:

Kubernetes Cron Jobs - Run multiple pods for a cron job

Our requirement is we need to do batch processing every 3 hours but single process can not handle the work load. we have to run multiple pods for the same cron job. Is there any way to do that ?
Thank you.

A:

You can provide parallelism: <num_of_pods> to cronjob.spec.jobTemplate.spec and it will run the multiple pods () at the same time.
Following is the example of a cronjob which runs 3 nginx pod every minute.
apiVersion: batch/v1beta1
kind: CronJob
metadata:
  creationTimestamp: null
  labels:
    run: cron1
  name: cron1
spec:
  concurrencyPolicy: Allow
  jobTemplate:
    metadata:
      creationTimestamp: null
    spec:
      parallelism: 3
      template:
        metadata:
          creationTimestamp: null
          labels:
            run: cron1
        spec:
          containers:
          - image: nginx
            name: cron1
            resources: {}
          restartPolicy: OnFailure
  schedule: '*/1 * * * *'
  concurrencyPolicy: Forbid
status: {}

source: minipile

textbook:
Lesson: How to Use Cron Jobs to Run Multiple Pods for Batch Processing

Introduction:
Cron jobs are used to schedule tasks in Kubernetes. In this lesson, we will learn how to use cron jobs to run multiple pods for batch processing. We will cover the following topics:

1. What are cron jobs?
2. How to create a cron job to run multiple pods for batch processing?
3. How to configure a cron job to run multiple pods in parallel?
4. How to troubleshoot issues with cron jobs?

What are cron jobs?
Cron jobs are a feature in Kubernetes that allows us to schedule tasks to run at specific times or intervals. They are useful for automating repetitive tasks, such as running batch processing jobs.

How to create a cron job to run multiple pods for batch processing?
To create a cron job to run multiple pods for batch processing, we need to follow these steps:

1. Define the pod template: This is a template that defines the pod that will be created when the cron job runs. It should include the necessary containers, volumes, and resources required for the batch processing job.

2. Create a job: A job is a template that defines how the pods should be created and managed. It should specify the number of replicas (pods) that should be created, the container image, and other details about the pod.

3. Create a cron job: A cron job is a resource that schedules the job to run at specific times or intervals. We need to provide the schedule (e.g., every 3 hours), the name of the job, and other details about the cron job.

Here is an example of a cron job that runs 3 nginx pods every minute:
```
apiVersion: batch/v1beta1
kind: CronJob
metadata:
  creationTimestamp: null
  labels:
    run: cron1
  name: cron1
spec:
  concurrencyPolicy: Allow
  jobTemplate:
    metadata:
      creationTimestamp: null
    spec:
      parallelism: 3
      template:
        metadata:
          creationTimestamp: null
          labels:
            run: cron1
        spec:
          containers:
            - image: nginx
              name: cron1
              resources: {}
            restartPolicy: OnFailure
  schedule: '*/1 * * * *'
```

How to configure a cron job to run multiple pods in parallel?
To run multiple pods in parallel, we need to set the `parallelism` field in the job template. This field specifies the number of replicas that should be created when the job runs. For example, if we set `parallelism: 3`, Kubernetes will create 3 pods when the job runs.

Here is an example of a cron job that runs 3 nginx pods in parallel:
```
apiVersion: batch/v1beta1
kind: CronJob
metadata:
  creationTimestamp: null
  labels:
    run: cron1
  name: cron1
spec:
  concurrencyPolicy: Allow
  jobTemplate:
    metadata:
      creationTimestamp: null
    spec:
      containers:
        - image: nginx
          name: cron1
          resources: {}
        restartPolicy: OnFailure
  schedule: '*/1 * * * *'
  parallelism: 3
```

How to troubleshoot issues with cron jobs?
If we encounter issues with our cron jobs, we can use the Kubernetes logging and debugging tools to diagnose the problem. For example, we can check the logs of the pods to see if they are running correctly or use the `kubectl logs` command to view the logs of the pods. We can also use the `kubectl describe` command to get more information about the pods, such as their status and events.

Conclusion:
In this lesson, we learned how to use cron jobs to run multiple pods for batch processing. We covered the basic concepts of cron jobs, how to create a cron job, how to configure a cron job to run multiple pods in parallel, and how to troubleshoot issues with cron jobs. We also provided an example of a cron job that runs 3 nginx pods every minute.


text: May RCRA hazardous waste facility personnel training be completed online and does EPA provide online training? There is no specific format required for RCRA facility personnel training, as long as the training program meets the minimum requirements in 40 CFR §264/265.16 or the appropriate generator training requirements. In addition, there is no specific EPA-designated program to meet RCRA training requirements. EPA does not provide a list of approved training programs or an online training. Have more questions? Submit a request

textbook:
Title: RCRA Hazardous Waste Facility Personnel Training

## Section 1: Introduction

In this lesson, we will learn about the RCRA hazardous waste facility personnel training requirements and how to meet them. We will cover the following topics:

- Who needs to complete RCRA hazardous waste facility personnel training?
- What are the minimum requirements for RCRA hazardous waste facility personnel training?
- Does EPA provide online training for RCRA hazardous waste facility personnel training?

## Section 2: Who Needs to Complete RCRA Hazardous Waste Facility Personnel Training?

According to the Resource Conservation and Recovery Act (RCRA), any person who handles, stores, or treats hazardous waste at a facility must complete RCRA hazardous waste facility personnel training. This includes:

- Site managers
- Supervisors
- Operators
- Maintenance workers
- Waste generators

## Section 3: What Are the Minimum Requirements for RCRA Hazardous Waste Facility Personnel Training?

The minimum requirements for RCRA hazardous waste facility personnel training are outlined in 40 CFR §264/265.16. These requirements include:

- Providing information on the hazards associated with handling hazardous waste
- Explaining the proper use and handling of personal protective equipment
- Describing the proper procedures for handling, storing, and treating hazardous waste
- Outlining the emergency procedures for spills and other accidents involving hazardous waste
- Discussing the employee's role in complying with RCRA and other applicable regulations

## Section 4: Does EPA Provide Online Training for RCRA Hazardous Waste Facility Personnel Training?

No, EPA does not provide a list of approved training programs or an online training for RCRA hazardous waste facility personnel training. However, there are many private companies that offer online training programs that meet the minimum requirements outlined in 40 CFR §264/265.16.

## Section 5: Conclusion

In conclusion, RCRA hazardous waste facility personnel training is required for anyone who handles, stores, or treats hazardous waste at a facility. The minimum requirements for this training are outlined in 40 CFR §264/265.16. While EPA does not provide online training, there are many private companies that offer online training programs that meet these requirements. By completing RCRA hazardous waste facility personnel training, employees can ensure they are knowledgeable about the hazards associated with hazardous waste and the proper procedures for handling, storing, and treating it.


text: Description. The fifth edition of Legal and Ethical Issues in Nursing is the essential book that combines legal and ethical knowledge for students and practicing nurses in one text. It reflects the continuing influence that the law, legal issues, and the field of ethics have on the professional practice of nursing.. Readers familiar with earlier editions will recognize that much of the content in this text is new or updated to mirror changes in the practice of professional nursing. This edition also combines the field of ethics with legal issues, as these two aspects of professional nursing practice cannot truly be separated.. Table of Contents. Part and Ethical Issues in Nursing, CourseSmart eTextbook, 5th Edition. Format: Safari Book. $30.99 | ISBN-13: 978-0-13-508548-6

textbook:
Lesson: Introduction to Legal and Ethical Issues in Nursing

Introduction:
Nursing is a profession that requires a high level of responsibility, accountability, and professionalism. Nurses are expected to provide safe and competent care to their patients, while adhering to the legal and ethical standards of their profession. In this lesson, we will explore the fundamental concepts of legal and ethical issues in nursing, including their importance, relevance, and application in practice.

Core Value:
The core value of this lesson is to provide a comprehensive understanding of legal and ethical issues in nursing, and their impact on patient care and professional practice.

Section 1: Importance of Legal and Ethical Issues in Nursing

Topic 1: Definition and Explanation
- Legal issues refer to the laws, rules, and regulations that govern the practice of nursing, while ethical issues involve the moral principles and values that guide nursing practice.
- Both legal and ethical issues are crucial in nursing because they help to protect the rights and welfare of patients, as well as maintain public trust and confidence in the profession.

Topic 2: Relevance to Nursing Practice
- Legal and ethical issues are relevant to nursing practice because they shape the way nurses provide care to their patients.
- Nurses must adhere to legal and ethical standards to ensure that they provide safe and competent care, while also respecting the rights and dignity of their patients.

Section 2: Application in Practice

Topic 1: Understanding the Legal Framework
- The legal framework governing nursing practice varies from country to country, but typically includes laws, rules, and regulations related to licensure, scope of practice, patient rights, and professional conduct.
- Nurses must be knowledgeable about the legal framework in their jurisdiction to ensure that they practice within the bounds of the law.

Topic 2: Applying Ethical Principles
- Ethical principles, such as autonomy, beneficence, non-maleficence, and justice, serve as a guide for nurses to make informed decisions about patient care.
- Nurses must use their judgment and critical thinking skills to apply these principles in practice, taking into account the unique needs and circumstances of each patient.

Section 3: Case Studies and Discussion

Topic 1: Case Study 1
- Scenario: A nurse discovers that a colleague has been stealing narcotic medications from the hospital's supply cabinet and replacing them with saline solution.
- Discussion: What should the nurse do? How do legal and ethical issues play a role in this scenario?

Topic 2: Case Study 2
- Scenario: A patient refuses a medical intervention that is recommended by the healthcare team.
- Discussion: How should the nurse handle this situation? What are the legal and ethical implications?

Conclusion:
In conclusion, legal and ethical issues are fundamental to nursing practice, as they help to ensure that patients receive safe and competent care, while also maintaining public trust and confidence in the profession. By understanding the importance and relevance of legal and ethical issues, nurses can apply these concepts in practice, while also recognizing the potential challenges and dilemmas that may arise. Through critical thinking and reflection, nurses can develop the skills necessary to navigate complex legal and ethical situations, while upholding the highest standards of professional practice.

Glossary:
- Autonomy: The right of individuals to make decisions about their own care, based on their personal values and preferences.
- Beneficence: The duty to promote the well-being and best interests of patients.
- Non-maleficence: The duty to avoid harming patients through negligent or reckless actions.
- Justice: The principle that healthcare resources should be distributed fairly and equitably, based on individual needs and circumstances.


text: Candelaria Garay is a Ford Foundation Associate Professor of Democracy at the Kennedy School of Government.) her second book project (manuscript in process), she explains why coalitions between labor unions and social movements of informal and/or rural workers have formed in some developing countries. She explores how these coalitions are established and analyzes their connections with political parties.. Other research projects focus on local healthcare services, the implementation of environmental legislation, and the interaction of political parties and social organizations in nascent democracies.. Courses. Political Institutions and Public PolicyDPI-101. This is a course about fundamental problems of participation, democratic governance, and conflict in contemporary political systems.. Latin American Politics and PolicymakingDPI-460. This course focuses on the politics of policymaking in contemporary Latin America.

textbook:
**Lesson:**
Introduction to Political Science

**Section 1: What is Political Science?**
Political science is the study of government and politics. It examines the behavior of individuals, groups, and institutions as they relate to the exercise of power and authority. Political science seeks to understand how and why people make decisions that affect their lives and the lives of others.

**Section 2: What do Political Scientists Study?**
Political scientists study a wide range of topics, including elections, public opinion, political parties, interest groups, the media, and international relations. They use various methods to gather and analyze data, such as surveys, interviews, and statistical analysis.

**Section 3: Why Study Political Science?**
Studying political science can help us understand how the world works and how we can improve it. By understanding how governments and societies function, we can make informed decisions about our own communities and countries. Additionally, political science can provide valuable skills for careers in law, business, education, journalism, and many other fields.

**Section 4: How do Political Scientists Work?**
Political scientists use a variety of methods to gather and analyze data. These methods include surveys, interviews, statistical analysis, and case studies. They also draw upon a range of theoretical perspectives to explain political phenomena.

**Section 5: Conclusion**
In conclusion, political science is a fascinating and rewarding field of study. By examining the behavior of individuals, groups, and institutions as they relate to the exercise of power and authority, we can gain a deeper understanding of the world around us. Whether you plan to pursue a career in politics or simply want to be a more informed citizen, studying political science can provide valuable insights and skills.


text: Description. The Lockwood 001 would have to be regarded as the benchmark of automatic deadlatches on the market today. Strength, durability, attractive design and high quality construction have combined to make the 001 an ideal lock for all domestic and many commercial applications.. This double cylinder deadlatch is suitable for open-in timber frame doors.. Features:. Automatic double cylinder deadlatch for timber frame.. LockAlert® function (red when engaged and green when released).. Safety Release™ (automatically unlocks the internal knob upon entry).. 60mm backset.. Internal lever. Cut resistant 18mm projection stainless steel bolt.. 11 concealed anchorage points.. Door frame strengthener.. Hold back function from both sides.. Is retrofitable and can replace most older style 001s. Suits door thickness 30-45mm.. Body dimensions 97mm (W) x 73mm (H) x 49mm (D). Internal and external 5 pin tumbler mechanism.. Compatible to most restricted keying systems and most regular key profiles.

textbook:
Lesson: Understanding Locks and Their Functions

Introduction:
Locks are essential components of our daily lives, providing security and protection to our belongings and properties. In this lesson, we will explore the different types of locks, their functions, and how they work. We will also learn about the importance of choosing the right lock for your needs and how to determine if a lock is of good quality.

Section 1: Types of Locks

There are several types of locks available in the market today, each with its unique features and functions. Some of the common types of locks include:

1. Padlocks: These are portable locks that can be used to secure any item or property. They come in various sizes and shapes and can be made from different materials such as metal or plastic.

2. Deadbolts: These are a type of lock that provides extra security to doors. They have a long bolt that extends into the doorframe, making it difficult for someone to force their way into a room.

3. Lever handles: These are locks that operate using a lever instead of a key. They are commonly found on doors and cabinets.

4. Mortise locks: These are locks that are installed within the door itself, making them difficult to remove without damaging the door.

Section 2: How Locks Work

Locks work by using a combination of mechanisms to keep a door or item locked. These mechanisms may include:

1. Tumbler lock: This type of lock uses a series of pins that must be aligned correctly for the lock to open. When the correct key is inserted, the pins move into position, allowing the lock to open.

2. Cylindrical lock: This type of lock uses a series of pins that must be aligned correctly for the lock to open. Unlike tumbler locks, however, cylindrical locks do not require a key to align the pins. Instead, a special tool called a "key" is used to turn the cylinder and align the pins.

3. Magnetic lock: This type of lock uses magnets to keep the door locked. When the door is closed, the magnets align, keeping the door locked. To unlock the door, the magnets must be separated.

Section 3: Choosing the Right Lock

When choosing a lock, there are several factors to consider, including:

1. Security level: Different locks provide different levels of security. For example, a deadbolt provides more security than a simple lever handle.

2. Durability: A good lock should be made from durable materials that can withstand wear and tear.

3. Ease of use: The lock should be easy to use and should not require excessive force to operate.

4. Compatibility: The lock should be compatible with your existing locking system.

Conclusion:

In conclusion, understanding the different types of locks and their functions can help you choose the right lock for your needs. Always ensure that you choose a lock that provides adequate security, is durable, and is easy to use. By following these guidelines, you can ensure that your property is well-protected.


text: Ohio State backup QB Cardale Jones made a name for himself with his tweet about attending classes and now it's being used in a textbook on how to conduct yourself on social media.. The textbook called "The Ole Miss Experience" is given to freshmen and Jones' tweet can be found in the "Best Practices on Social Media" section.. Remember, everyone: just one tweet is all it takes to become famous, and it's not always a good thing.. Hat tip to Lost Lettermen for the find.

textbook:
Lesson: The Importance of Social Media Etiquette
Introduction:
Social media has become an integral part of our lives. It allows us to connect with people from all over the world, share our thoughts and ideas, and stay updated on current events. However, it is essential to use social media responsibly and with caution. This lesson will teach you the importance of social media etiquette and how to conduct yourself on social media platforms.
Section 1: Understanding Social Media Etiquette
Topic 1: Best Practices on Social Media
- Be aware of your online presence and what you post on social media.
- Use appropriate language and avoid using offensive or derogatory terms.
- Respect other people's opinions and beliefs.
- Do not share personal information such as your address or phone number.
- Avoid posting sensitive information about others without their consent.
- Be mindful of your online reputation and what you post.
Topic 2: The Power of Social Media
- Social media can make or break your reputation.
- It can help you connect with people and build relationships.
- It can also be a platform for cyberbullying and harassment.
- Be aware of the power of social media and use it responsibly.
Section 2: Practical Examples
Example 1: Cardale Jones' Tweet
- Jones made a tweet about attending classes, which went viral.
- The tweet was meant to be funny, but it backfired and caused controversy.
- Jones learned a valuable lesson about the power of social media and its impact on his reputation.
Example 2: The Ole Miss Experience Textbook
- The textbook includes Jones' tweet as an example of how not to conduct oneself on social media.
- The textbook teaches freshmen the importance of social media etiquette and how to use social media responsibly.
Section 3: Self-Debating Discussions
Topic 1: How important is social media etiquette?
- Social media etiquette is crucial because it helps us build relationships and maintain our online reputation.
- It also prevents us from saying or doing things that could harm ourselves or others.
Topic 2: How can we apply social media etiquette in real life?
- Social media etiquette applies to all forms of communication, not just social media.
- We should treat others with respect and dignity, even if they disagree with us.
- We should also be mindful of our online presence and how we present ourselves to the world.
Conclusion:
In conclusion, social media etiquette is an essential skill that we must learn to use effectively. It helps us build relationships, maintain our online reputation, and prevent harm to ourselves or others. By following the best practices on social media and being mindful of our online presence, we can use social media responsibly and with caution.


text:
An ongoing adventure of travel and living while using a wheelchair. Tim has been disabled from birth. Darryl is his father and caregiver who travels with him.
Email us at
dmusick61
at
gmail-dot-com
All content, images, and video copyright 2009,2010, 2011, 2012, 2013, 2014, 2015, 2016, and 2017 - Darryl, Letty, and Tim Musick

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Wednesday, July 5, 2017

Fields of Dreams: Minute Maid Park - Houston, Texas

Minute Maid Park is the home of the Houston Astros and displaces the now unused Astrodome, an historical landmark it shared with the Houston Oilers football team. It's located in downtown Houston, beside (and incorporating) the old Union Station train depot.

Originally, the team was known as the Houston Colt 45's. In fact, I made sure I got and wore a replica Colt 45's t-shirt to the game. A lot of old-time Houston fans at the game let me know how much they appreciated the gesture. The team was an expansion to the National League in 1962, the same year the New York Mets started their MLB career.

Houston became the nerve center of the country's space program with the creation of Johnson Space Center and everything became space-themed. The new indoor stadium became known as the Astrodome and the team changed names to the Astros to pay homage to American Astronauts.

The dome was a modern marvel in its day, cutting edge in stadium design, but 1965 modern didn't translate into new millennium modern. Houston had just lost their football team by not giving them a modern stadium to move into. They weren't about to lose the baseball team for the same reason and construction began on a new downtown stadium in 1997. The Astros opened their 2000 season in the new, modern, retractable roof stadium with natural grass (as opposed to the synthetic grass developed especially for the Astrodome, dubbed Astroturf).

Naming rights soon went to Enron, an energy company that soon found itself broiled in scandal, then the Astros went to CocaCola who ponied up the money to name the stadium after its juice brand. Because of that, the stadium now has the unofficial nickname the "juicebox."A few years ago when the team was moved to the American League, the Astros were kind of a laughing stock for having a miniscule budget, no-name players, and an awful record. The team management basically said "wait, this is part of an improvement plan." It must have been a pretty good plan because they have steadily worked themselves up the standings and, as of this writing, sit atop the American League West standings a whopping 12 games over the second place Angels and the season is not even half over.

Minute Maid Park seems huge when you’re outside but gets a more intimate feel once you're in. Perhaps because a large part, the old Union Station where the team has its offices and gift shop, really sits outside of the seating bowl making it larger than it feels. The staff is professional and fans are very welcoming to out-of-towners. It’s know as a hitter-friendly park despite the long distance to center field but is does have fairly short power alleys.

In addition to the long distance to center field, there used to be a small hill and flagpole here that was in play. Saner heads prevailed and the ground was flattened and the flagpole removed after the 2016 season.

Another unique feature, paying homage to the stadium's former life as a train station, is a full-size replica locomotive that travels across the top of the left field stands whenever the home team hits a home run. Also, look for the corner window at the top of the office building beyond the left field foul pole with the noticeably thicker glass and a 422 feet marker under it. That's the owner's office and one day at batting practice, someone hit a ball there, shattered the glass, and made a mess of the interior. The office was cleaned up, the sign installed, and...now...thick shatterproof glass makes sure this won't be repeated (story was told to me by our usher).

The seating bowl features three larger decks and a small level of suites, two decks in right field and a smaller deck in left. The Texas heat is left behind when it gets too hot...the roof is closed and the air conditioning turned on. If the weather is pleasant, the roof is opened.

Wheelchair seating is liberally spread out through the park. We opted for the club level, near the right field foul pole. Our seats were on a very comfortable and roomy deck above the seats below.They were about the same price as the seats we had back at Globe Life Park but much more comfortable. An Interior food court was directly behind us.Hot dogs here are good. Very good and big. The park is also know for it's street tacos which are good too. Beer selection is also very good and the food and drink prices are a little above average.

Public transportation to the park is good with a trolley station a block away. Houston has a good light rail system in the downtown area and it connects with a lot of hotels.

Minute Maid Park now displaces Miller Park in Milwaukee as our favorite domed/retractable roof stadium in the majors. It's a wonderful place to see a ballgame in or out of a wheelchair.Darryl MusickCopyright 2017 - All Rights ReservedPhotos by Letty MusickCopyright 2017 - All Rights Reserved

textbook:
Lesson: Introduction to Discrete Mathematics

**Objective:** To introduce students to the basics of discrete mathematics, including sets, functions, and logic.

**Overview:** Discrete mathematics is the branch of mathematics that deals with objects that can be counted and have distinct values. This includes topics such as number theory, combinatorics, graph theory, and probability. In this lesson, we will cover the basics of discrete mathematics, including sets, functions, and logic.

**Section 1: Sets**

A set is a collection of objects that are all alike in some way. For example, the set of all even numbers between 1 and 10 would be {2, 4, 6, 8, 10}. Sets can contain any type of object, including numbers, letters, shapes, or even other sets.

**Exercise:** Create a set of your favorite fruits.

**Answer:** {apple, banana, orange, strawberry}

**Section 2: Functions**

A function is a relationship between two sets of objects. For example, if we have a set of numbers called "x" and a set of numbers called "y", we can define a function f(x) = y such that f(2) = 4 and f(3) = 9. The function takes one object from the first set (in this case, x) and returns an object from the second set (in this case, y).

**Exercise:** Define a function that takes a number between 1 and 10 and returns the number multiplied by 2.

**Answer:** f(x) = 2x

**Section 3: Logic**

Logic is the study of the rules of correct reasoning. It involves using symbols and words to represent statements and arguments, and then analyzing those statements and arguments to see if they are true or false.

**Exercise:** Is the following argument logical?

Premise 1: All dogs like to chase their tails.
Premise 2: Fido is a dog.
Conclusion: Therefore, Fido likes to chase his tail.

**Answer:** No, the argument is not logical because it assumes that all dogs are the same, which is not true.

**Glossary:**
- Set: A collection of objects that are all alike in some way
- Function: A relationship between two sets of objects
- Logic: The study of the rules of correct reasoning

**Conclusion:** In this lesson, we introduced students to the basics of discrete mathematics, including sets, functions, and logic. We covered the definition of each concept, provided examples, and included exercises for students to practice. By the end of this lesson, students should have a solid understanding of the fundamentals of discrete mathematics and be able to apply them to new problems.


text: I with a heartfelt story as Van William explores heartbreak in many ways, from the loss of his family business, to the ending of a six year relationship.. Rather than being full of melancholy however, William manages to stay upbeat and I really think this came from recording the album among friends. The energy that would have been in that studio shines beautifully throughout Countries and I cannot help but feel a little lighter after listening to it.. Not only did it help me out of my writing slump, but it encouraged me to look forward in life and let my passions thrive. Read my full review for Vulture Hound here:. Follow me on Twitter and Instagram for more updates, and make sure to follow Vulture Hound too: Facebook // Twitter

textbook:
Lesson:
Title: Countries by Van William - A Review
Level: Primary School
Objective: To analyze a piece of music and its impact on the listener.
Introduction: In this lesson, we will be discussing the album "Countries" by Van William. We will analyze the themes present in the music, the emotions it evokes, and the impact it has on the listener.
Section 1: Themes in the Music
Topic: What are the themes present in the music?
Question: What are some of the themes present in the music?
Answer: Some of the themes present in the music include heartbreak, loss, and moving forward.
Discussion: Let's discuss some of the themes present in the music. Can you think of any other themes that might be present?
Section 2: Emotions Evoked
Topic: What emotions does the music evoke?
Question: How does the music make you feel?
Answer: The music evokes feelings of sadness, but also hope and positivity.
Discussion: Let's talk about how the music makes you feel. Does it make you feel any other emotions?
Section 3: Impact on the Listener
Topic: What impact does the music have on the listener?
Question: How does the music affect you?
Answer: The music can inspire listeners to move forward in their own lives and pursue their passions.
Discussion: Let's discuss the impact the music has on the listener. How do you think the music affects others?
Conclusion: In this lesson, we have analyzed the themes present in the music "Countries" by Van William, the emotions it evokes, and the impact it has on the listener. We have discussed how the music can inspire us to move forward in our own lives and pursue our passions.
Glossary:
- Themes: The main ideas or topics present in a piece of music.
- Emotions: Feelings or sensations that a piece of music can evoke in the listener.
- Impact: The effect that a piece of music has on the listener.
- Inspire: To motivate or encourage someone to do something.


text:
Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.
Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinical efficacy has been investigated intensively across the world. However, the underlying neurobiological mechanisms of the antidepressant effect of rTMS are still not fully understood. This review aims to systematically synthesize the literature on the neurobiological mechanisms of treatment response to rTMS in patients with depression. Medline (1996-2014), Embase (1980-2014) and PsycINFO (1806-2014) were searched under set terms. Three authors reviewed each article and came to consensus on the inclusion and exclusion criteria. All eligible studies were reviewed, duplicates were removed, and data were extracted individually. Of 1647 articles identified, 66 studies met both inclusion and exclusion criteria. rTMS affects various biological factors that can be measured by current biological techniques. Although a number of studies have explored the neurobiological mechanisms of rTMS, a large variety of rTMS protocols and parameters limits the ability to synthesize these findings into a coherent understanding. However, a convergence of findings suggest that rTMS exerts its therapeutic effects by altering levels of various neurochemicals, electrophysiology as well as blood flow and activity in the brain in a frequency-dependent manner. More research is needed to delineate the neurobiological mechanisms of the antidepressant effect of rTMS. The incorporation of biological assessments into future rTMS clinical trials will help in this regard.

textbook:
Lesson: Introduction to Neurobiological Mechanisms of rTMS in Depression

**Objective:** To introduce students to the neurobiological mechanisms of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression.

**Key Concepts:** Neurobiology, depression, rTMS, dorsolateral prefrontal cortex, antidepressant effect, neurotransmitters, synaptic plasticity.

**Materials:** Whiteboard or paper, markers, computer/projector, internet access.

**Activity 1: Brainstorming - What do we know about depression?**

Ask students to brainstorm and share what they know about depression. Record their responses on the whiteboard or paper.

**Activity 2: Introduction to rTMS**

Explain to students that rTMS is a non-invasive technique that uses magnetic fields to stimulate specific areas of the brain. It has been shown to be effective in treating depression, particularly in cases where other treatments have failed.

**Activity 3: Discussion - What are the possible neurobiological mechanisms of rTMS in depression?**

Ask students to discuss and brainstorm potential neurobiological mechanisms that could explain the antidepressant effect of rTMS. Some possible mechanisms include changes in neurotransmitter levels, synaptic plasticity, and connectivity between different brain regions.

**Activity 4: Research and Presentation**

Divide students into groups and assign each group a specific neurobiological mechanism to research. Have each group present their findings to the class, including relevant studies and evidence supporting their chosen mechanism.

**Activity 5: Conclusion - How can we apply this knowledge to new problems?**

Ask students to reflect on what they have learned and how it could be applied to future research or treatment strategies for depression. For example, if we understand the neurobiological mechanisms behind rTMS, could we develop more targeted or effective treatments for depression?

**Glossary:**

- Neurobiology: The study of the nervous system and its functioning at the cellular and molecular level.
- Depression: A mental disorder characterized by persistent feelings of sadness, hopelessness, and lack of interest in activities.
- rTMS: A non-invasive technique that uses magnetic fields to stimulate specific areas of the brain.
- Dorsolateral prefrontal cortex: A region of the brain involved in executive functions such as decision-making and attention.
- Antidepressant effect: The therapeutic effect of an intervention (such as rTMS) on depression symptoms.
- Neurotransmitters: Chemical messengers that transmit signals between nerve cells.
- Synaptic plasticity: The ability of synapses to strengthen or weaken over time in response to changes in their activity.

**Conclusion:**

In this lesson, we introduced students to the neurobiological mechanisms of rTMS in the treatment of depression. We explored the potential mechanisms behind this treatment, including changes in neurotransmitter levels, synaptic plasticity, and connectivity between different brain regions. Students engaged in research and presentation activities to deepen their understanding of these mechanisms and their implications for future research and treatment strategies. By learning about the neurobiological basis of rTMS, students can gain a deeper appreciation for the complexity of the brain and the potential for targeted treatments for mental illness.


text: Description. Kate Kelly has always been overshadowed by her famous brother Ned, but the talented young woman was a popular public figure in her own right. This moving biography tells her astonishing story in full for the first time... ‘Rarely told in full, this is the fascinating life of one of the great characters in one of our greatest stories.’ – Paul Terry, author of The True Story of Ned Kelly’s Last Stand. ‘Thoroughly recommended not only to those who have an interest in bushranging and the Kelly dynasty but anyone who enjoys a well-written and riveting yarn, based on fact.’ – Rob Willis OAM, National Library of Australia Oral History and Folklore Collections. Book Reviews Reviews. There are no reviews yet.

textbook:
Lesson Title: The Life of Kate Kelly: A Biographical Study

Introduction:
Kate Kelly was a remarkable woman who lived during the 19th century in Australia. Despite being overshadowed by her famous brother Ned, she was a popular public figure in her own right. In this lesson, we will explore the life of Kate Kelly and learn about her astonishing story.

Section 1: Early Life and Family
- What was Kate Kelly's early life like?
- How did her family influence her life?
- Why was she often compared to her brother Ned?

Section 2: Popularity and Controversies
- What made Kate Kelly a popular public figure?
- What were some of the controversies surrounding her life?
- How did she handle criticism and scrutiny?

Section 3: Legacy and Impact
- What was Kate Kelly's legacy?
- How did her life impact society?
- What can we learn from her story?

Glossary:
- Biography: a detailed account of a person's life
- Overshadowed: to be less prominent or important than someone or something else
- Talented: having a natural ability or skill
- Public figure: a person who is well-known and has a prominent role in society
- Controversies: disputed or doubtful matters
- Scrutiny: close examination or critical attention
- Legacy: a gift or a bequest, especially of money, property, or other assets

Conclusion:
In conclusion, the life of Kate Kelly is a fascinating story that teaches us about perseverance, resilience, and determination. Despite being overshadowed by her brother Ned, she managed to make a name for herself and become a popular public figure. Her legacy serves as an inspiration to many, and her story reminds us that even in the shadows of others, we can still make a difference in the world. By studying the life of Kate Kelly, we can learn valuable lessons about life, society, and the importance of leaving a lasting impact.


text: The Inforum is a popular venue for program and class exhibitions, and all kinds of academic and professional events. Multiple airy and well-lit spaces over two floors make it ideal for multi-track events. A large space on the 4th floor is equipped with a fully-wired podium, a ceiling mounted sound system, projection screen, and comfortable seating for 100 people.. For information on event planning, see our Inforum Event Booking Policy, as well as our extensive Events in the Inforum: Preparation guide for organizers.. We balance student study needs with the frequency of events, so if you are thinking of the Inforum for an event, be sure to get your request in early!. Images: 1) Employers' Showcase student-run event, January 2017; 2) Lari Langford, Inforum Director, at the December 2016 end-of-term party, traditionally held in the Inforum, with the Gingerbread House of Information made by Prof. Jenna Hartel.

textbook:
Lesson: How to Plan and Host an Event
Introduction:
Planning and hosting an event can be a challenging task, but it can also be a rewarding experience. Whether you are organizing a small gathering or a large conference, there are several steps you need to take to ensure that your event is successful. In this lesson, we will cover the basics of event planning, including how to choose a venue, create a budget, promote your event, and manage registration. By the end of this lesson, you will have a solid understanding of the event planning process and be able to apply these skills to any event you may plan in the future.
Section 1: Choosing a Venue
The first step in planning an event is to choose a venue. This can be a daunting task, but there are several factors you should consider when selecting a location. These include:
- Capacity: You need to make sure that the venue can accommodate the number of people you expect to attend.
- Accessibility: The venue should be easy to access for all attendees, whether they are driving, taking public transportation, or walking.
- Amenities: Does the venue have the necessary equipment and facilities to support your event? For example, do you need audio-visual equipment, catering facilities, or parking?
- Cost: The cost of the venue is an important factor to consider. You need to make sure that you can afford the space without going over budget.
Once you have considered these factors, you can begin researching potential venues. Start by making a list of all the possible locations in your area, and then narrow down your options based on your criteria. Finally, schedule visits to each venue to get a better feel for the space and ask any questions you may have.
Section 2: Creating a Budget
After you have chosen a venue, it’s time to create a budget. A budget is essential because it helps you keep track of your expenses and ensures that you don’t overspend. Here are some steps you can take to create a budget:
- Determine your revenue sources: Figure out how much money you have coming in from ticket sales, sponsorships, or other sources.
- List your expenses: Make a list of all the costs associated with your event, such as venue rental, catering, marketing, and equipment rentals.
- Subtract your expenses from your revenue: Once you have your revenue and expenses listed, subtract the expenses from the revenue to determine your net profit.
- Set a contingency fund: It’s always a good idea to set aside some extra money in case of unforeseen expenses or emergencies.
- Stick to your budget: Once you have your budget, stick to it as closely as possible. This means being mindful of your spending and looking for ways to cut costs where you can.
Section 3: Promoting Your Event
Promoting your event is essential to ensure that people know about it and attend. Here are some ways you can promote your event:
- Social media: Use social media platforms like Facebook, Twitter, and Instagram to spread the word about your event. Create an event page and invite all your friends and followers.
- Email marketing: Send out an email newsletter to your email list promoting your event. Make sure to include all the relevant information, such as date, time, location, and price.
- Flyers and posters: Create flyers and posters to distribute around town. Place them in local businesses, community centers, and other high-traffic areas.
- Local media: Reach out to local media outlets, such as newspapers, radio stations, and TV stations, to see if they would be interested in covering your event.
- Word of mouth: Encourage your attendees to spread the word about your event to their friends and family.
Section 4: Managing Registration
Once you have promoted your event, it’s time to start managing registrations. Here are some steps you can take to manage registrations:
- Set up a registration system: You can use an online platform like Eventbrite or Google Forms to manage registrations.
- Set a deadline: Set a deadline for registration to ensure that you have an accurate headcount for your event.
- Send reminders: Send out reminder emails to people who have registered to ensure that they remember to attend.
- Manage walk-ins: If you are allowing walk-ins, make sure to have a system in place to manage them.
- Follow up: After the event, follow up with attendees to thank them for coming and to gather feedback.
Conclusion:
In conclusion, planning and hosting an event requires careful consideration and organization. By following the steps outlined in this lesson, you can create a successful event that meets your goals and exceeds the expectations of your attendees. Remember to stay organized, communicate effectively, and be flexible as you navigate the event planning process. With these skills, you will be well on your way to hosting memorable and impactful events.
Glossary:
- Venue: A place where an event takes place.
- Budget: A financial plan that outlines expected income and expenses.
- Contingency fund: Extra money set aside for unexpected expenses.
- Registration: The process of signing up for an event.
- Walk-ins: People who attend an event without having registered in advance.


text: Introduction: Jonestown: The Life and Death of Peoples TempleOther Introductions. ’s eighteen – were all murdered.” Stanley Clayton, one of the few who escaped alive, clearly states his opinion in the film: “That man was killin’ us.”. My American Experience. Share Your Story. We invite you to tell us your own stories - whether you lived through a tumultuous time period or learned about it from a relative, a book or a movie.

textbook:
Lesson: The Jonestown Massacre

### Section 1: Introduction

The Jonestown Massacre was a tragedy that occurred in 1978 in Guyana, South America. Over 900 people died in what became known as the largest mass suicide in history. This lesson will explore the events leading up to the massacre, the people involved, and the aftermath.

### Section 2: Background

The Jonestown settlement was established in 1974 by the Peoples Temple, a religious group led by Reverend Jim Jones. The group initially gained fame for their social justice work in California, but eventually moved to Guyana after facing criticism and scrutiny in the United States.

The members of the Peoples Temple believed in communal living and shared everything they had with each other. However, as time went on, Jones became more paranoid and controlling, restricting the members' access to the outside world and their families.

### Section 3: The Massacre

On November 18, 1978, Congressman Leo Ryan arrived at Jonestown to investigate allegations of human rights violations. He was accompanied by several journalists and defectors from the Peoples Temple.

Jones allowed Ryan to meet with the defectors, but as they were leaving, gunfire erupted. Ryan and four others were killed. The next day, Jones ordered a mass suicide, instructing his followers to drink cyanide-laced punch. Over 900 people died, including Jones himself.

### Section 4: Aftermath

The Jonestown massacre shocked the world and led to increased scrutiny of cults and religious groups. It also sparked debate over mental health and the role of leaders in such tragedies.

Many survivors struggled to come to terms with what had happened and faced stigma and isolation. Some even blamed themselves for not dying alongside their loved ones.

### Section 5: Conclusion

The Jonestown massacre was a tragic event that took the lives of over 900 people. It serves as a reminder of the dangers of blindly following a leader and the importance of questioning authority. By understanding the events that led up to the massacre and the aftermath, we can learn from this tragedy and work to prevent similar events from happening in the future.


text: A few days after the race. on May 1 so I decided to take it easy, a nice 15 km ride out to the start,. a brisk (and windy) 70 km ride, some coffee and cake, and then the 15 km. back home.. I was actually going to do. a longer course, so the night before I'd eaten plenty of pasta in preparation.. I got up on the Sunday morning at 6ish and looked out the window. Rain.. Persisting it down. Ah well, methinks, better shift some of that pasta.. At least the rain let up a bit. Still a pretty wet 75 km mind. And the. other cyclists are few and far between. No streamlining today!. A nice ride out into the. northern section of the Odenwald in the company of half a dozen like-minded. souls. Not to mention the other 200 participants ...

textbook:
Lesson: How to Ride a Bike in the Rain

Introduction:
Riding a bike in the rain can be challenging, but with the right preparation and safety measures, it can also be a fun and rewarding experience. In this lesson, we will learn about the necessary equipment, clothing, and techniques to stay safe and dry while cycling in the rain.

Section 1: Preparation

Before riding in the rain, make sure to prepare your bike and yourself properly. Here are some essential steps:

1. Check your bike: Inspect your bike for any damage or loose parts that may become loose in the rain. Make sure your brakes are working correctly and that your tires are inflated to the recommended pressure.

2. Change your tires: If you have a road bike, consider switching to wider tires with more tread for better grip on wet roads. If you have a mountain bike, make sure your tires are still in good condition and have enough tread for off-road riding.

3. Clean your bike: Give your bike a thorough cleaning to remove any dirt or debris that could cause damage to your components.

4. Choose the right clothing: Wear waterproof clothing that allows you to move freely and keeps you warm and dry. Consider wearing a waterproof jacket, pants, gloves, and a helmet with a visor to keep the rain out of your eyes.

Section 2: Safety Measures

Once you're prepared, follow these safety measures to ensure a safe and enjoyable ride:

1. Slow down: Rainy conditions can make roads slippery and reduce visibility. Reduce your speed and give yourself extra time to react to hazards on the road.

2. Keep your distance: Leave more space between you and the vehicle in front of you to allow for sudden stops or skids.

3. Use your brakes carefully: Wet brake pads can lose their effectiveness, so use them sparingly and slowly to avoid skidding. If you're riding downhill, consider using a lower gear to control your speed without relying on your brakes.

4. Be visible: Make sure you're visible to other road users by wearing reflective clothing or accessories and using lights on your bike.

Section 3: Practical Examples

Let's apply what we've learned in a practical example:

Scenario: You're riding home from work when it starts raining heavily. You didn't bring your rain pants, but you have a waterproof jacket and gloves. What should you do?

1. Slow down and be extra careful on wet roads.
2. Use your waterproof jacket and gloves to stay dry and protected.
3. Keep your speed low and leave more space between you and other vehicles.
4. Use your lights and reflective gear to be visible to other road users.

Conclusion:

Riding a bike in the rain can be challenging, but with the right preparation and safety measures, it can be a fun and rewarding experience. By following the steps outlined in this lesson, you can stay safe and dry while enjoying the benefits of cycling in all weather conditions.


text: Kira Peterson. Kira Peterson is a Senior Campus Recruiting Manager at Capital One Financial Services. In her role she manages programs including Capital One’s Analyst Internship Program, Summit for Developing Leaders, Human Resources Rotation Program. Kira is also responsible for leading campus recruiting diversity initiatives including partnerships with national, regional and on-campus organizations.. Prior to joining Capital One, Kira held positions supporting recruitment in multiple industries including consulting and law. She is a graduate of Hollins University in Roanoke, Virginia with a Bachelor’s degree in Communications and Sociology. Kira lives in Richmond, Virginia.

textbook:
Lesson: Introduction to Recruiting and Diversity Initiatives

## Section 1: What is Recruiting?
Recruiting is the process of finding and attracting qualified candidates to fill job openings within an organization. It involves identifying the needs of the organization, sourcing potential employees, screening and selecting the best candidates, and onboarding them into their new roles.

## Section 2: Why are Diversity Initiatives Important in Recruiting?
Diversity initiatives are important in recruiting because they help organizations create a more inclusive workplace that values and respects individual differences. This includes differences in race, gender, age, religion, disability, and sexual orientation. By actively seeking out and recruiting diverse candidates, organizations can benefit from a wider range of perspectives, experiences, and skills, which can lead to better problem-solving, innovation, and overall performance.

## Section 3: How can Recruiting Support Diversity Initiatives?
Recruiting can support diversity initiatives by developing partnerships with organizations that serve underrepresented communities, such as national, regional, and on-campus organizations. Additionally, recruiters can work to remove barriers that may prevent diverse candidates from applying or succeeding in the hiring process. This could include providing accommodations for individuals with disabilities or offering flexible work arrangements for those with family responsibilities.

## Section 4: Practical Examples
One practical example of how recruiting can support diversity initiatives is through targeted outreach efforts. For instance, a company might partner with a local organization that serves women in STEM fields to recruit female candidates for their engineering team. Another example could be offering remote work options for individuals who may have limited mobility due to a disability.

## Section 5: Self-Debating Discussion
Why do you think it's important for companies to prioritize diversity in their recruiting efforts? What challenges might they face when trying to achieve this goal?

## Glossary:
- Diverse candidates: Individuals who come from different backgrounds and possess unique perspectives, experiences, and skills.
- Underrepresented communities: Groups of people who are not well-represented in certain industries or organizations, such as women in tech or people of color in leadership roles.
- Accommodations: Adjustments made to the workplace or hiring process to make it more accessible for individuals with disabilities.
- Flexible work arrangements: Options that allow employees to adjust their work schedules or work from home, which can benefit those with family responsibilities or other commitments.

## Conclusion:
In summary, recruiting plays a crucial role in finding and attracting qualified candidates to fill job openings within an organization. Diversity initiatives are important in recruiting because they help create a more inclusive workplace that values individual differences. Recruiters can support these initiatives by developing partnerships with organizations that serve underrepresented communities and removing barriers that may prevent diverse candidates from applying or succeeding in the hiring process. By prioritizing diversity in their recruiting efforts, companies can benefit from a wider range of perspectives, experiences, and skills, which can lead to better problem-solving, innovation, and overall performance.


text:
Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition.
We have studied the role of pivotal bio-molecules involved in signalling of cytotoxic effects induced by paclitaxel (Ptx) on acute promyelocytic human leukaemia NB4 cells. A time-dependent increase in cell death and DNA cleavage was observed after 30μM Ptx treatment. Cell death induction by Ptx proceeds mainly as programmed cell death as shown by annexin V-FITC, reaching up to 30% of apoptotic cells after 24h. Significant reductions of p53, changes in Bax and Bcl-2 and activation of caspases 3 and 9 were observed as the treatment was applied for long times. Ptx treatments produced NFkB depletion with expression levels abolished at 19h what could be involved in reduction of survival signals. Phosphorylation of intracellular kinases showed that pERK1/2 decreased significantly at 19h of Ptx treatment. When these cells were preincubated for 90min with 20μM PD98059, 2'-amino-3'-methoxyflavone, an inhibitor of ERK phosphorylation, a slight reduction of cell viability was observed in comparison to that produced by Ptx alone. Pretreatment with PD98059 neither activated caspases nor significantly increased the apoptotic effect of Ptx. Taken together, our data reveal that the inhibition of ERK phosphorylation does not seem to be an essential pathway for bursting an increased induction of apoptosis by Ptx. Decrease of p53 and Bcl-2, fragmentation of DNA, increase of Bax and, finally, activation of caspases 3 and 9 in NB4 leukaemia cells make the apoptotic process induced by Ptx irreversible. Application of Ptx in leukaemia cells shows therefore a promising potential with particular effects on different leukaemia cell types.

textbook:
Lesson: Understanding Cell Death Induced by Paclitaxel
Introduction:
Cell death is a crucial process that occurs naturally in living organisms. It is essential for maintaining homeostasis and eliminating damaged or unwanted cells. There are two main types of cell death: apoptosis and necrosis. Apoptosis is a regulated form of cell death that occurs in response to specific signals, while necrosis is an uncontrolled form of cell death that results from severe cellular injury.
In this lesson, we will focus on apoptosis induced by paclitaxel, a chemotherapy drug used to treat various types of cancer, including leukemia. We will explore the role of pivotal bio-molecules involved in the signaling pathway of cytotoxic effects of paclitaxel on acute promyelocytic human leukemia NB4 cells.
Main Topics:
1. Introduction to cell death and paclitaxel
2. Apoptosis and its role in cancer therapy
3. Paclitaxel's mechanism of action
4. Bio-molecules involved in paclitaxel's cytotoxic effects
5. Activation of Bcl-2, Bax, and caspases 3 and 9
6. ERK inhibition and its effect on cell death
7. Conclusion and application of skills gained
Section 1: Introduction to Cell Death and Paclitaxel
Cell death is a natural process that occurs in living organisms. It is essential for maintaining homeostasis and eliminating damaged or unwanted cells. There are two main types of cell death: apoptosis and necrosis. Apoptosis is a regulated form of cell death that occurs in response to specific signals, while necrosis is an uncontrolled form of cell death that results from severe cellular injury.
Paclitaxel is a chemotherapy drug used to treat various types of cancer, including leukemia. It works by targeting microtubules, which are essential for cell division. By disrupting microtubule formation, paclitaxel prevents cancer cells from dividing and growing.
Section 2: Apoptosis and Its Role in Cancer Therapy
Apoptosis is a crucial process in the development and maintenance of multicellular organisms. It helps to eliminate damaged or unwanted cells and maintain tissue homeostasis. In cancer therapy, apoptosis is often targeted to kill cancer cells while sparing healthy cells.
Paclitaxel induces apoptosis in cancer cells by activating several signaling pathways, including the intrinsic mitochondrial pathway and the extrinsic death receptor pathway. This leads to the activation of caspases, a family of proteases that play a crucial role in the execution of apoptosis.
Section 3: Paclitaxel's Mechanism of Action
Paclitaxel works by targeting microtubules, which are essential for cell division. It binds to tubulin, a protein that forms microtubules, and stabilizes them. This prevents cancer cells from dividing and growing. Additionally, paclitaxel induces apoptosis by activating several signaling pathways, including the intrinsic mitochondrial pathway and the extrinsic death receptor pathway. This leads to the activation of caspases, a family of proteases that play a crucial role in the execution of apoptosis.
Section 4: Bio-molecules Involved in Paclitaxel's Cytotoxic Effects
Several bio-molecules are involved in the cytotoxic effects of paclitaxel. These include:
- Bcl-2: a protein that regulates apoptosis by controlling the release of cytochrome c from the mitochondria.
- Bax: a pro-apoptotic protein that promotes the release of cytochrome c from the mitochondria.
- Caspases 3 and 9: proteases that play a crucial role in the execution of apoptosis.
Section 5: Activation of Bcl-2, Bax, and Caspases 3 and 9
Paclitaxel induces apoptosis in cancer cells by activating several signaling pathways, including the intrinsic mitochondrial pathway and the extrinsic death receptor pathway. This leads to the activation of caspases, a family of proteases that play a crucial role in the execution of apoptosis. Additionally, paclitaxel activates the pro-apoptotic protein Bax and the anti-apoptotic protein Bcl-2, which regulate the release of cytochrome c from the mitochondria.
Section 6: ERK Inhibition and Its Effect on Cell Death
Phosphorylation of intracellular kinases showed that pERK1/2 decreased significantly at 19h of Ptx treatment. When these cells were preincubated for 90min with 20μM PD98059, 2'-amino-3'-methoxyflavone, an inhibitor of ERK phosphorylation, a slight reduction of cell viability was observed in comparison to that produced by Ptx alone. Pretreatment with PD98059 did not significantly affect cell death induced by Ptx.
Section 7: Conclusion and Application of Skills Gained
In conclusion, our study shows that paclitaxel induces apoptosis in NB4 human leukemia cells through the activation of Bcl-2, Bax, and caspases 3 and 9. ERK inhibition did not modulate cell death induced by paclitaxel. These findings provide insights into the molecular mechanisms underlying paclitaxel-induced apoptosis and may contribute to the development of novel therapeutic strategies for leukemia treatment.
Glossary:
- Apoptosis: a regulated form of cell death that occurs in response to specific signals.
- Bcl-2: a protein that regulates apoptosis by controlling the release of cytochrome c from the mitochondria.
- Bax: a pro-apoptotic protein that promotes the release of cytochrome c from the mitochondria.
- Caspases 3 and 9: proteases that play a crucial role in the execution of apoptosis.
- ERK: extracellular signal-regulated kinase, a kinase that plays a crucial role in cell growth and differentiation.
- PD98059: an inhibitor of ERK phosphorylation.
- Ptx: paclitaxel, a chemotherapy drug used to treat various types of cancer, including leukemia.
- NB4: acute promyelocytic human leukemia cells.
Self-Debating Discussion:
1. Why is it essential to understand the mechanisms behind apoptosis and cell death?
2. How does paclitaxel induce apoptosis in cancer cells?
3. What are the roles of Bcl-2, Bax, and caspases 3 and 9 in paclitaxel's cytotoxic effects?
4. How does ERK inhibition affect cell death induced by paclitaxel?
5. What are the potential applications of understanding the molecular mechanisms underlying paclitaxel-induced apoptosis?
Conclusion:
In this lesson, we have explored the role of pivotal bio-molecules involved in the signaling pathway of cytotoxic effects of paclitaxel on acute promyelocytic human leukemia NB4 cells. We have discussed the mechanisms behind apoptosis and the role of paclitaxel in inducing apoptosis in cancer cells. Additionally, we have explored the roles of Bcl-2, Bax, and caspases 3 and 9 in paclitaxel's cytotoxic effects and the effect of ERK inhibition on cell death. Finally, we have discussed the potential applications of understanding the molecular mechanisms underlying paclitaxel-induced apoptosis in the development of novel therapeutic strategies for leukemia treatment.


text: What’s happening in Rainbow Schools?. MSS student takes home gold and bronze medal at Special Olympics. Reegan Millsap has something to smile about. The Manitoulin Secondary School student won the gold medal for the 200-metre snowshoe race at the Canada Special Olympic Winter Games held in Alberta from February 27 to March 3. Reegan also received the bronze medal for the 100-metre snowshoe race. Judy Olacke, a teacher at Manitoulin Secondary School, was one of the proud coaches of the Ontario Olympic team.

textbook:
Lesson: Special Olympics and Canada Winter Games

## Introduction
The Special Olympics is an international organization that provides opportunities for individuals with intellectual disabilities to participate in sports and physical activities. The Canada Special Olympic Winter Games are held every four years and bring together athletes from across the country to compete in various winter sports. In this lesson, we will learn about the Special Olympics, the Canada Winter Games, and the importance of physical activity for individuals with intellectual disabilities.

## Section 1: The Special Olympics

### Topic 1: What is the Special Olympics?
The Special Olympics is an international organization that provides opportunities for individuals with intellectual disabilities to participate in sports and physical activities. It was founded in 1968 by Eunice Kennedy Shriver, who believed that everyone, regardless of their abilities, should have the opportunity to participate in sports and physical activities.

### Topic 2: What are the goals of the Special Olympics?
The goals of the Special Olympics are to provide opportunities for individuals with intellectual disabilities to participate in sports and physical activities, to promote social inclusion and acceptance, and to foster a sense of community and belonging. Through these activities, the Special Olympics aims to improve the physical, mental, and social well-being of individuals with intellectual disabilities.

### Topic 3: How does the Special Olympics work?
The Special Olympics is divided into different programs, including the Special Olympics Schools Program, the Special Olympics Community Program, and the Special Olympics National Games. These programs provide opportunities for individuals with intellectual disabilities to participate in sports and physical activities at the local, regional, and national levels.

## Section 2: The Canada Winter Games

### Topic 4: What is the Canada Winter Games?
The Canada Winter Games is a multi-sport event that brings together athletes from across the country to compete in various winter sports. The Games are held every four years and are organized by the Canada Games Council, a non-profit organization that promotes sport and physical activity in Canada.

### Topic 5: When and where were the last Canada Winter Games held?
The last Canada Winter Games were held in Red Deer, Alberta, from February 27 to March 3, 2020. Over 1,700 athletes from across Canada participated in the event, which featured 20 different sports.

### Topic 6: Who can participate in the Canada Winter Games?
To participate in the Canada Winter Games, athletes must be residents of Canada and be between the ages of 12 and 24. They must also be selected by their respective provincial or territorial sport organizations.

## Section 3: Physical Activity and Intellectual Disabilities

### Topic 7: Why is physical activity important for individuals with intellectual disabilities?
Physical activity is important for individuals with intellectual disabilities because it can improve their physical, mental, and social well-being. Regular physical activity can help individuals with intellectual disabilities develop stronger muscles and bones, maintain a healthy weight, and reduce the risk of chronic diseases such as heart disease and diabetes. Physical activity can also improve cognitive function, reduce stress and anxiety, and enhance self-esteem and confidence.

### Topic 8: What types of physical activities can individuals with intellectual disabilities participate in?
Individuals with intellectual disabilities can participate in a wide range of physical activities, including swimming, dancing, soccer, basketball, and track and field. They can also participate in adapted sports, such as wheelchair basketball and adaptive skiing, which are designed specifically for individuals with disabilities.

## Conclusion
In conclusion, the Special Olympics and the Canada Winter Games provide valuable opportunities for individuals with intellectual disabilities to participate in sports and physical activities. Physical activity can improve their physical, mental, and social well-being, and promote social inclusion and acceptance. By participating in these events, individuals with intellectual disabilities can develop self-confidence, self-esteem, and a sense of community.

Glossary:
- Special Olympics: an international organization that provides opportunities for individuals with intellectual disabilities to participate in sports and physical activities.
- Canada Winter Games: a multi-sport event that brings together athletes from across the country to compete in various winter sports.
- Intellectual disability: a disability characterized by significant limitations in intellectual functioning and in adaptive behavior, which covers many aspects of a person's life.
- Physical activity: any form of exercise or movement that uses the body's muscles and bones.


text:
Increasing role of arthropod bites in tularaemia transmission in Poland - case reports and diagnostic methods.
The study describes four cases of tularaemia - one developed after contact with rabbits and three developed after an arthropod bite. Due to non-specific clinical symptoms, accurate diagnosis of tularaemia may be difficult. The increasing contribution of the arthropod vectors in the transmission of the disease indicates that special effort should be made to apply sensitive and specific diagnostic methods for tularaemia, and to remind health-care workers about this route of Francisella tularensis infections. The advantages and disadvantages of various diagnostic methods - molecular, serological and microbiological culture - are discussed. The PCR as a rapid and proper diagnostic method for ulceroglandular tularaemia is presented.

textbook:
Lesson Title: Understanding Tularaemia Transmission in Poland

Introduction:
Tularaemia is a rare infectious disease caused by the bacterium Francisella tularensis. It is primarily spread through contact with infected animals or arthropod bites. In this lesson, we will learn about the increasing role of arthropod bites in the transmission of tularaemia in Poland, the diagnostic methods used to identify the disease, and the importance of accurate diagnosis.

Section 1: Understanding Tularaemia Transmission in Poland

Topic 1: Cases of Tularaemia in Poland
- In a recent study, researchers described four cases of tularaemia in Poland.
- One case was caused by contact with rabbits, while the other three were caused by arthropod bites.
- The study highlights the increasing contribution of arthropod vectors in the transmission of tularaemia in Poland.

Topic 2: Diagnosing Tularaemia
- Accurate diagnosis of tularaemia is important because the symptoms are non-specific and can be mistaken for other illnesses.
- Various diagnostic methods are used to identify tularaemia, including molecular, serological, and microbiological culture.
- Polymerase chain reaction (PCR) is a rapid and proper diagnostic method for ulceroglandular tularaemia and is presented in the study.

Section 2: Advantages and Disadvantages of Diagnostic Methods

Topic 1: Molecular Methods
- Molecular methods, such as PCR, are highly sensitive and specific for detecting Francisella tularensis.
- However, they require specialized equipment and trained personnel to perform the test.

Topic 2: Serological Methods
- Serological methods, such as enzyme-linked immunosorbent assay (ELISA), are easy to perform and require minimal equipment.
- They are less sensitive and specific than molecular methods, but they can be used to detect antibodies against F. tularensis.

Topic 3: Microbiological Culture
- Microbiological culture is a traditional method for isolating and identifying bacteria.
- It is time-consuming and requires specialized equipment and trained personnel.
- It is also less sensitive and specific than molecular methods.

Section 3: Applying Diagnostic Methods in Practice

Topic 1: PCR for Ulceroglandular Tularaemia
- PCR is a rapid and proper diagnostic method for ulceroglandular tularaemia.
- It is highly sensitive and specific, making it a reliable method for detecting F. tularensis.
- It can be used in clinical settings and does not require specialized equipment or trained personnel.

Topic 2: Reminding Health-Care Workers About Arthropod-Borne Transmission
- The increasing contribution of arthropod vectors in the transmission of tularaemia in Poland indicates that special effort should be made to apply sensitive and specific diagnostic methods for tularemia.
- Health-care workers should be reminded about this route of Francisella tularensis infections.

Conclusion:
In conclusion, understanding the increasing role of arthropod bites in the transmission of tularaemia in Poland is crucial for accurate diagnosis and treatment of the disease. The advantages and disadvantages of various diagnostic methods should be considered when selecting a method for detecting tularaemia. PCR is a rapid and proper diagnostic method for ulceroglandular tularaemia and is recommended for use in clinical settings. Finally, health-care workers should be reminded about the arthropod-borne transmission of tularaemia in Poland.

Glossary:
- Arthropod: A type of invertebrate animal having an exoskeleton, segmented body, and jointed appendages.
- Bacterium: A single-celled microorganism that lacks a nucleus and can reproduce only within a living host.
- Diagnostic method: A technique used to identify a disease or condition.
- Francisella tularensis: A bacterium that causes tularaemia.
- Infection: The invasion of an organism's body by disease-causing agents such as bacteria, viruses, or parasites.
- Tularaemia: A rare infectious disease caused by the bacterium Francisella tularensis.

[1] "Increasing role of arthropod bites in tularaemia transmission in Poland - case reports and diagnostic methods." Przegląd Epidemiologiczny. 2019;73(4):615-618.


text: I used to ride when I was in my 20s and now have returned and bought a new Felt Z100 and remember why I loved riding. I am 55 years old and had 4 way by-pass surgury about a year ago. I was 225lbs when I started riding and this morning I was 200. Looking to get down to 175, so I am halfway to my goal. I ride about 8 miles in the mornings and Saturdays about 20 to 25 miles. I only average about 14mph over these rides and am a little discouraged when I see the others saying they average 20!! Looking forward to my next ride!

textbook:
Lesson: The Benefits of Cycling

Introduction:
In this lesson, we will explore the many benefits of cycling, both for your physical and mental health. We will discuss the positive effects of cycling on weight loss, cardiovascular health, and overall well-being.

Section 1: Physical Benefits of Cycling
Cycling is an excellent form of exercise that can help you stay fit and healthy. It is a low-impact activity that is easy on the joints, making it suitable for people of all ages and fitness levels. Here are some of the physical benefits of cycling:

1. Weight Loss: Cycling is an effective way to burn calories and lose weight. According to the Harvard Health Letter, a 150-pound person can burn around 400 calories per hour of cycling. This can help you achieve your weight loss goals.

2. Cardiovascular Health: Cycling is an excellent form of cardiovascular exercise that can help improve your heart health. It strengthens the heart muscle, lowers blood pressure, and reduces the risk of heart disease.

3. Muscle Strength: Cycling is a great way to build muscle strength, particularly in the legs, glutes, and core. This can improve your overall physical performance and make daily tasks easier.

Section 2: Mental Benefits of Cycling
In addition to the physical benefits, cycling also has many mental health benefits. Cycling can help reduce stress, anxiety, and depression, and improve overall mental well-being.

1. Stress Reduction: Cycling is an excellent way to reduce stress and clear your mind. It can help you focus and feel more relaxed, both during and after your ride.

2. Mood Boost: Cycling releases endorphins, which are natural mood boosters. This can help improve your overall mood and make you feel happier and more energized.

3. Cognitive Function: Regular cycling has been shown to improve cognitive function, including memory, attention, and problem-solving skills.

Section 3: Tips for Successful Cycling
To get the most out of your cycling experience, here are some tips to help you succeed:

1. Start Slow: If you are new to cycling or have been away from it for a while, start slow and gradually increase your mileage and intensity.

2. Choose the Right Bike: Make sure you choose a bike that fits you properly and is comfortable to ride.

3. Wear the Right Gear: Wearing the right clothing and protective gear can help you stay comfortable and safe while cycling.

4. Stay Hydrated: Drink plenty of water before, during, and after your ride to stay hydrated and avoid cramps and other issues.

Conclusion:
Cycling is an excellent form of exercise that can help you stay fit, healthy, and happy. By incorporating cycling into your daily routine, you can achieve your weight loss goals, improve your cardiovascular health, and enjoy the many mental health benefits that come with regular exercise. So, get out there and start pedaling!

Glossary:
- Cardiovascular: Relating to the heart and blood vessels
- Endorphins: Natural mood boosters produced by the body
- Mileage: The distance traveled by a cyclist in a given ride
- Intensity: The level of effort or exertion required during a workout


text: Quick Summary. Create a through-hole footprint to eventually place on your printed circuit board (PCB) in Cadence OrCAD / Allegro PCB Editor 17.2. Enjoy!. Tutorial industry leading PCB design software for large scale printed circuit board designs. Every serious electronics design engineer should know OrCAD to be competitive in major hardware design engineering within the computer tech industry. OrCAD Tutorial for beginners, PSpice Tutorial for beginners.. You can get even better at the PCB Design Process. Go from zero to hero in OrCAD Capture, PCB Editor and PSpice for circuit design and simulation. Ask kirsch@learnorcadonline.com for a discount and course coupons. Find our website at:. Twitter:. Instagram:…

textbook:
Lesson: Introduction to PCB Design with OrCAD

## Section 1: Overview
In this lesson, we will learn the basics of creating a printed circuit board (PCB) design using OrCAD, a popular PCB design software. We will cover the following topics:

1. Importance of PCB design
2. Overview of OrCAD features
3. Creating a new PCB project
4. Adding components to the schematic
5. Placing components on the PCB layout
6. Routing traces and connecting components
7. Saving and exporting the design

## Section 2: Importance of PCB Design
A PCB is a fundamental component in any electronic device. It serves as the foundation for all electrical connections and provides a pathway for signals to travel between different components. A well-designed PCB can improve the performance, reliability, and manufacturability of an electronic product.

## Section 3: Overview of OrCAD Features
OrCAD is a powerful PCB design software that offers a range of features to help engineers create high-quality designs. Some of its key features include:

1. Schematic capture: OrCAD allows you to create a schematic diagram of your circuit, which represents the logical connections between components.
2. PCB layout: OrCAD provides a powerful PCB editor that enables you to place components on the board, route traces, and add various layers to your design.
3. Simulation: OrCAD includes a built-in simulator that allows you to test your circuit before building the actual PCB.
4. Library management: OrCAD comes with a library of standard components, which can be customized to suit your specific needs.
5. DFM (Design for Manufacturing): OrCAD has tools to ensure that your design meets manufacturing standards and is easy to produce.

## Section 4: Creating a New PCB Project
To begin designing a PCB using OrCAD, you need to create a new project. Follow these steps:

1. Open OrCAD and click on "File" > "New Project".
2. Select the type of project you want to create (e.g., PCB or Schematic).
3. Choose the template that best suits your needs.
4. Enter a name for your project and click "OK".

## Section 5: Adding Components to the Schematic
Once you have created a new project, you can start adding components to your schematic. To do this, follow these steps:

1. Click on "Schematic" in the main menu bar.
2. Click on "Add" > "Component".
3. Select the component you want to add from the library.
4. Place the component on the schematic and connect it to other components using wires.

## Section 6: Placing Components on the PCB Layout
After creating the schematic, you can move on to placing components on the PCB layout. Follow these steps:

1. Click on "PCB Editor" in the main menu bar.
2. Click on "Place" > "Component".
3. Select the component you want to place from the library.
4. Click on the desired location on the PCB to place the component.

## Section 7: Routing Traces and Connecting Components
Now that you have placed the components on the PCB, you can route traces to connect them. Follow these steps:

1. Click on "Route" > "New Route".
2. Select the starting point for the trace.
3. Click on the endpoint for the trace.
4. OrCAD will automatically route the trace for you. If necessary, adjust the route to meet design rules.
5. Repeat steps 1-4 for each component connection.

## Section 8: Saving and Exporting the Design
Once you have finished routing the traces, it's time to save and export your design. Follow these steps:

1. Click on "File" > "Save As" to save your project.
2. Choose a location to save the project file.
3. Click on "File" > "Export" to export the design to a different format (e.g., Gerber files for manufacturing).
4. Select the desired export options and click "Export".

## Glossary
- PCB: Printed Circuit Board
- OrCAD: A PCB design software
- Schematic: A diagram that represents the logical connections between components
- PCB Editor: A tool for placing components on the PCB layout
- Simulation: A process of testing a circuit before building the actual PCB
- Library: A collection of standard components
- DFM: Design for Manufacturing

## Conclusion
In this lesson, we learned the basics of creating a PCB design using OrCAD. We covered the importance of PCB design, the features of OrCAD, and the steps involved in creating a new project, adding components to the schematic, placing components on the PCB layout, routing traces, and saving and exporting the design. By mastering these skills, you can become a proficient PCB designer and contribute to the development of advanced electronic products.


text: Planning a strong push into the games sector, social network hi5 has hired outspoken industry veteran Alex St. John as president and chief technology officer.. Until late last year, St. John was CEO of online gaming destination WildTangent. Previously, he was a Microsoft bigwig, whose credits include co-creating DirectX. His responsibilities at the San Francisco-based hi5 will include product development, technology and audience acquisition.. He commented, "The next wave of innovation and differentiation in gaming is happening in social gaming and hi5 is at the forefront of this sea change. I’ve long said that the current generation of game consoles will be the last and that the future of the game business will be online.". Although a minnow compared to Facebook, hi5 has 60 million unique monthly users, and an avowed strategy to grow via community-based videogames. Back in 2008, St. John predicted to MCV that "the retail business for boxed games will completely dry up".. Advertisement

textbook:
Lesson: Introduction to Game Development

## Section 1: Theoretical Concepts
In this lesson, we will learn about the basics of game development. We will cover the following concepts:

1. What is game development?
2. Why is game development important?
3. Who are the key players in game development?

## Section 2: Practical Examples
Now that we understand the theoretical concepts, let's look at some practical examples of game development. We will use the following scenarios:

1. Developing a simple game using a game engine
2. Creating a mobile game using Unity
3. Designing a multiplayer game using Unreal Engine

## Section 3: Self-Debating Discussions
Let's engage in self-debating discussions to further our understanding of game development. We will explore the following topics:

1. How do game developers balance gameplay and storytelling?
2. What are the challenges of developing a successful game?
3. How do game developers stay up-to-date with the latest technology?

## Glossary
- Game development: The process of creating games, including design, programming, and production.
- Game engine: A software framework used for creating games.
- Unity: A popular game engine used for developing mobile games.
- Unreal Engine: A game engine used for developing multiplayer games.

## Conclusion
In this lesson, we learned about the basics of game development, including the key players and processes involved. We also explored practical examples and engaged in self-debating discussions to further our understanding. By applying these skills, we can create our own games and contribute to the exciting world of game development.


text:
Winooski Archeological Site

The Winooski Archeological Site, designated VT-CH-46 by state archaeologists, is a prehistoric Native American site in the city of Winooski, Vermont.  First identified in 1972, it is one of the largest Native encampment sites of the Middle Woodland period in the northeastern United States.  It was listed on the National Register of Historic Places in 1978, at which time it was recognized as one of just two stratified Woodland period sites in the state.

Description
The Winooski Archeological Site is located on a terrace above the north bank of the Winooski River.  It is demarcated on its sides by marshy terrain, which may have made the area a peninsula at the time of its occupation.  The site is highly stratified, with cultural materials interbedded with silt from river flooding.  Finds at the site include remnants of fire pits, ceramic fragments, stone tools and projectile points, and the debris (debitage) from stone tool manufacture.  It is possible that this site is the location of "Winoosqueak", a native settlement mentioned in early French accounts of the region.

The site was first identified in 1972 by an amateur member of the Vermont Archaeological Society, and was from an early date considered at risk due to river erosion.  Surveys and investigations through the 1970s under the leadership of state archaeologists identified the bounds and scope of the site.  Stone finds at the site were quarried from sites as far off as Pennsylvania, and the ceramic finds are stylistically consistent with traditions found in the Saint Lawrence River valley and the Great Lakes.  It is unclear whether the site was subject to long-term seasonal occupation, or repeated short-term occupations, something further archaeological investigation might reveal.

See also
National Register of Historic Places listings in Chittenden County, Vermont

References

Category:Archaeological sites on the National Register of Historic Places in Vermont
Category:National Register of Historic Places in Chittenden County, Vermont
Category:Winooski, Vermont

textbook:
Lesson: Introduction to Archaeology

## Chapter 1: What is Archaeology?

**Introduction:** In this lesson, we will learn about the study of archaeology and how it helps us understand the past.

**What is Archaeology?** Archaeology is the scientific study of human history and culture through the excavation and analysis of artifacts and other physical remains of past societies. It helps us understand how people lived, what they did, and why they did it.

**Why is Archaeology Important?** Archaeology is important because it provides a unique window into the past. By studying the remains of ancient cultures, we can learn about their ways of life, their beliefs, and their accomplishments. This knowledge helps us understand our own history and culture and makes us appreciate the diversity of human experience.

**How does Archaeology work?** Archaeologists use a variety of methods to study the past. They excavate sites, analyze artifacts, and interpret the data they collect. They also use dating techniques to determine the age of artifacts and sites.

**Case Study: Winooski Archeological Site**

The Winooski Archeological Site is a prehistoric Native American site in Vermont. It was first identified in 1972 and is one of the largest Middle Woodland period sites in the northeastern United States. The site has been extensively studied and has provided valuable insights into the lives of Native Americans during this period.

**Conclusion**

In this lesson, we learned about the study of archaeology and how it helps us understand the past. We also explored the importance of archaeology and how it works. Finally, we looked at a case study of the Winooski Archeological Site to see how archaeology can provide valuable insights into the past.